Editorial, J Metabonomics Metabolites Vol: 1 Issue: 1
An Unbiased Approach to Discover Novel Therapies for Liver Disease
| Colleen Croniger* |
| Department of Nutrition, Case Western Reserve University, Cleveland Ohio 44107, USA |
| Corresponding author : Colleen Croniger, PhD Department of Nutrition, Case Western Reserve University, Cleveland Ohio 44107, USA Tel: +1-216-368-4967; Fax: +1-216-368-6644 E-mail: cmc6@case.edu |
| Received: June 12, 2012 Accepted: June 13, 2012 Published: June 15, 2012 |
| Citation: Croniger C (2012) An Unbiased Approach to Discover Novel Therapies for Liver Disease. J Metabonomics Metabolites 1:1. doi:10.4172/2325-9736.1000e101 |
Abstract
An Unbiased Approach to Discover Novel Therapies for Liver Disease
Alcoholic liver disease (ALD) represents a range of clinical and morphological changes that range from steatosis to inflammation and necrosis (alcoholic hepatitis) to progressive fibrosis (alcoholic cirrhosis). Most chronic heavy drinkers exhibit steatosis characterized by greater amount of macrovesicular fat content than microvesicular fat. In addition hepatocyte ballooning degeneration with mixed lobular inflammation is evident.
