Tackling Primary Cilia Dysfunction in Photoreceptor Degenerative Diseases of the Eye

Perception of what is occurring around us relies extensively on our senses, such as vision, smell and touch. Among these, vision attracts remarkable attention. The ability to see makes us appreciate life. For years, investigators have been seeking answers to remarkable capabilities of the eye to perceive and interpret light signal and any kind of disturbances causing loss of vision and degenerative ocular diseases. Answers to such questions are essential to develop a cure for people suffering from dysfunction of visual process. This editorial summarizes recent trends in the development of our understanding of a class of degenerative diseases of eye, which are caused by defects in polarized protein trafficking in photoreceptors, the light-sensing neurons in the retina.