Research Article, J Liver Dis Transplant Vol: 1 Issue: 2
Cerebral Expression of NKCC1 in Rats with Acute and Chronic Hyperammonemia
| Martin Eefsen1*, Ben Vainer2, Hanne Cathrine Bisgaard3 and Fin Stolze Larsen1 | |
| 1Department of Hepatology, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark | |
| 2Department of Pathology, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark | |
| 3Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark | |
| Corresponding author : Martin Eefsen, MD Department of Hepatology, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark Tel: +45 3545 2121; Fax: +45 3545 2913 E-mail: Martin@Eefsen.dk |
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| Received: November 06, 2012 Accepted: December 30, 2012 Published: January 02, 2013 | |
| Citation: Eefsen M, Vainer B, Bisgaard HC, Larsen FS (2012) Cerebral Expression of NKCC1 in Rats with Acute and Chronic Hyperammonemia. J Liver: Dis Transplant 1:2. doi:10.4172/2325-9612.1000104 |
Abstract
Cerebral Expression of NKCC1 in Rats with Acute and Chronic Hyperammonemia
Acute Liver Failure (ALF) is a severe medical condition, primarily defined by high plasma-ammonia levels, multiorgan failure and development of Hepatic Encephalopathy (HE), while chronic liver failure is defined by chronic low level hyperammonemia and development of HE. Newly research showed that increased cerebral expression of the ion-channel Na+, K+, Cl- co-transporter I (NKCC1) is associated with brain edema development in several medical clinical conditions.
