Research Article, J Pharm Drug Deliv Res Vol: 2 Issue: 2
Comparative Modeling of Serotonin Receptors 5ht2a and 5ht2c and In-silico Investigation of their Potential as Off-Target to Ethinylestradiol
Rehab Yousif Mohamed Idrees1* and Asaad Khalid2 |
1Faculty of Pharmacy, University of Khartoum, Sudan |
2Medicinal and Aromatic Plants Research Institute, National Center for Research Khartoum-11111, Sudan |
Corresponding author : Rehab Yousif Mohamed Idrees Faculty of Pharmacy, University of Khartoum, Sudan E-mail: rehabbashaaree@gmail.com |
Received: January 04, 2013 Accepted: May 21, 2013 Published: May 23, 2013 |
Citation: Mohamed Idrees RY, Khalid A (2013) Comparative Modeling of Serotonin Receptors 5ht2a and 5ht2c and In-silico Investigation of their Potential as Off-Target to Ethinylestradiol. J Pharm Drug Deliv Res 2:2. doi:10.4172/2325-9604.1000117 |
Abstract
Comparative Modeling of Serotonin Receptors 5ht2a and 5ht2c and In-silico Investigation of their Potential as Off-Target to Ethinylestradiol
The side effects of contraceptives in general and combined oral contraceptives in particular are numerous and are limiting factors in many cases leading to cease their use. At the same time the combined oral contraceptives or synthetic estrogens are increasingly being used in Medicine today. Several studies have addressed estrogen – serotonin interaction and it has been found that estrogen through its own receptors affect serotonin`s function. Here we hypothesized that synthetic estrogen may affect serotonin function by binding to serotonin receptors as off-target ones; therefore manipulate its function and further on explaining the mechanism by which side effects resulting from the use of synthetic estrogen (ethinylestradiol) take place.