Research Article, Cell Biol Res Ther Vol: 3 Issue: 1
Differential Binding of Aspergillus fumigatus Allergenic Proteins to Human Leukocyte Antigen (HLA) Alleles in Dry Lab: Potential for Immunotherapy
| Hamid Nawaz Tipu*, and Dawood Ahmed |
| Combined Military Hospital, Khuzdar Cantt, Pakistan |
| Corresponding author : Dr. Hamid Nawaz Tipu MBBS, FCPS (Immunology), Classified Pathologist & Consultant Immunologist, Combined Military Hospital, Khuzdar Cantt, Pakistan Tel: 00923-335-478-215 E-mail: hnt1779@yahoo.com |
| Received: April 15, 2014 Accepted: June 18, 2014 Published: July 10, 2014 |
| Citation: Tipu HN, Ahmed D (2014) Differential Binding of Aspergillus fumigatus Allergenic Proteins to Human Leukocyte Antigen (HLA) Alleles in Dry Lab: Potential for Immunotherapy. Cell Biol: Res Ther 3:1. doi:10.4172/2324-9293.1000111 |
Abstract
Aspergillus fumigatus is the commonest mold implicated in pathogenesis of allergic broncho pulmonary aspergillosis (ABPA), condition almost exclusively seen in patients with asthma and cystic fibrosis . Several immunological mechanisms have been implicated including immediate hypersensitivity (type I), antigen antibody complexes (type III) and inflammatory cell responses (type IV) according to the Gell and Coombs classification. One component of the involved complex pathogenetic mechanism is that antigens from inhaled conidia are processed and presented to T lymphocytes with activation of Th2 CD4+ T cells. The release of Th2 pathway cytokines (IL-4, IL-5 and IL-13) leads to IgE synthesis, mast cell degranulation and an eosinophilic response.
