The journal Drug Intoxication & Detoxification: Novel Approaches (DIDNA) promotes rigorous research that makes a significant contribution in advancing knowledge in the fields of Pharmaceutical & Medicine.
Drug Intoxication & Detoxification: Novel Approaches is a subscription based journal that provides a range of options to purchase our articles and also permits unlimited Internet Access to complete Journal content. It accepts research, review papers, online letters to the editors & brief comments on previously published articles or other relevant findings in SciTechnol. Articles submitted by authors are evaluated by a group of peer review experts in the field and ensures that the published articles are of high quality, reflect solid scholarship in their fields, and that the information they contain is accurate and reliable.
Too often the medical community lends a deaf ear to patients who have vague complaints of adverse reactions to prescribed medications. In no population is this more common than in the treatment of the elderly. How can we comprehend this skepticism? One bias may be due to the tremendous attention given to the normal aging process and the knowledge that as one gets older we tend to heal slower, ache more and find ourselves associated with a decline in various physiological and cognitive functioning. Because of our defensive nature of doubting that our recommendations of therapy could actually be associated with a decline in various bodily functionings.
Defining the Role of Single Nucleotide Polymorphic (SNP) in Drug Development and Toxicity
The sequencing of human genome has lead to define the variations among humans, which is quite astonishing. Before sequencing of human genome, variant among genes were observed as mutations.It was known that mutations in key regulatory and functional genes cause diseases. With the advent of single nucleotide polymorphism (SNP) among genes, which is believed to be present in every 1.0 kb in human genome (3X106 SNP in 3X109 bps genome), has changed the very paradigm of disease progression, drug action and toxicity.
Drugs and the Environment: A Call for Change in Drug Dispensing Practice
Recent studies noting the appearance of drugs in several environmental water sources have generated public concern and scientific inquiry into the best approaches for reducing the presence of drugs in these sources. In many cases, the concentration of drugs found in these water sources are several orders of magnitude below what would reasonably be considered toxic, even when accounting for the potential synergistic effects among several drug classes identified in these studies. Unfortunately, there is significant variation in the concentration of environmental drugs; especially when considering water sources that are close to wastewater treatment plants or landfills.
The Thin Line to Prescribed Opioid Addiction, how to Identify and Prevent the Risk for the Deviant Behavior and Opioid Overdose
There is a thin line between being on prescribed opioids for long term treatment of chronic non cancer pain and being addicted to opioids. Some patients may cross this thin line. Their primary care providers would be in a dilemma either to deny the treatment of pain or to support their addictive behavior. How to address this dilemma is the first important question to answer. To address this dilemma there is a need for collaboration between primary care providers, pain specialists and addiction specialist.First, primary care providers need to understand the difference between physiological dependence versus being addicted to opioids i.e., opioid abuse or dependence.
The Addicted Brain: Why we Abuse Drugs, Alcohol and Nicotine by Michael Kuhar
The book describes how the brain is involved in the progression of the disease of addiction 113. It is composed of 14 chapters covering the whole journey of addiction from the first exposure to the full blown picture of the disease. It covers the animal models to explain how the brain gets involved. It is very interesting to learn that the animal model for addiction was discovered accidently where scientists was working on a different experiment. The book describes in details the brain reward system including how various neurotransmitters activate the target brain regions like the corticomesolimbic circuit.