Research Article, J Sleep Disor Treat Care Vol: 3 Issue: 4
Effects of Sleep Deprivation on Exhaled Nitric Oxide Concentrations in Medical Residents Taking Night Call
Catherine Oberg1, Sam Eljammal2, Haven Malish2, Kendra Becker1, Jaymica Patel1, Alex Balekian2, and Ahmet Baydur2 |
1Divisions of General Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA |
2Pulmonary and Critical Care Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA |
Corresponding author : Dr. Ahmet Baydur 2020 Zonal Avenue, IRD 723, Los Angeles, CA 90033, USA E-mail: baydur@usc.edu |
Received: July 02, 2014 Accepted: September 08, 2014 Published: September 11, 2014 |
Citation: Oberg C, Eljammal S, Malish H, Becker K, Patel J, et al., (2014) Effects of Sleep Deprivation on Exhaled Nitric Oxide Concentrations in Medical Residents Taking Night Call. J Sleep Disor: Treat Care 3:4. doi:10.4172/2325-9639.1000145 |
Abstract
Effects of Sleep Deprivation on Exhaled Nitric Oxide Concentrations in Medical Residents Taking Night Call
Background: Exhaled nitric oxide (eNO) is considered a biomarker for airway inflammation, and has been studied most extensively in asthma. It has also been implicated as a biomarker in other forms of stress, including psychological, although results have been variable. Sleep deprivation in medical residents on duty can be stressful. Objective: The purpose of this study was to determine whether sleep deprivation was linked to altered levels of eNO and, if so, whether eNO concentrations (FeNO) could be reliably used as a simple, non-invasive measure of inflammation in varying degrees of sleep deprivation. Our hypothesis was that FeNO levels are higher during sleep deprivation. Given that taking night call can be a stressful situation (leading to sleep disruption), we asked (1) what is the relationship between FeNO in physician trainees and sleep deprivation, and (2) can FeNO be viewed as a marker for inflammation in sleep deprivation during on-call duty?