The Journal of Immunodeficiency & Disorders (JIDD) promotes rigorous research that makes a significant contribution in advancing knowledge for immune system and related disorders. JIDD includes all major themes pertaining to immunological deficiencies and their preventative measures.
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More than a decade ago, Bannert and colleagues first reported that human mast cell (MC) progenitors are susceptible to infection with HIV-1. This finding was confirmed and extended by other groups in the following years providing in vivo evidence that tissue MCs, developing from infected human MC progenitors, remain productively infected in infected people. Moreover, evidence was shown that Toll-like receptor (TLR) 2, TLR4, or TLR9 stimulation of latently infected mast cells induced re-initiation of HIV-1 replication.
Primary immunodeficiencies (PIDs) result from inherited mutations in genes involved in the production, function or survival of specific elements of the immune system (T, B, NK lymphocytes, neutrophils, antigen-presenting cells). Knowing that these elements derive from pluripotent hematopoietic stem cells, it has been tried to use allogeneic hematopoietic stem cell transplantation (HSCT) as an alternative for patients with a PID, which has proven to be an effective therapeutic approach leading to immune restoration.
Non-Antibacterial Implications of Tetracyclines in the Management of Periodontitis: An Update
Recent research has shown that the majority of the soft and hard tissue destruction in periodontitis occurs due to activated host immuneinflammatory defence mechanisms in response to bacterial plaque. The importance of the host inflammatory response in periodontal pathogenesis presents opportunity for exploring new treatment strategies for periodontitis by means of host modulation. One of such treatment strategy is the use of drugs like Chemically Modified Tetracyclines, which are derivatives of tetracycline group of antibiotics, but lack antimicrobial action and have potent host modulating properties. The main advantage of Chemically Modified Tetracyclines over conventional tetracyclines is that they do not produce the side effects such as gastro-intestinal toxicity and antibiotic resistance.
Hydatid cyst is the larval stage of the tapeworm, Echinococcus granulosus, a parasite responsible for hydatid disease or hydatidosis in human and livestock. This disease considered as one of the most important cosmopolitan zoonotic infection with different mammalian hosts being involved in the life cycle. It has been shown that in a large retrospective study of patients with cancer, the prevalence of hydatid cyst was significantly lower than in normal subjects. Antitumor activity of some other parasites have also been demonstrated.