International Publisher of Science, Technology and Medicine

Journal of Nanomaterials & Molecular Nanotechnology

Review Article

In vivo General Trends, Filtration and Toxicity of Nanoparticles

Grant A Hartung and G Ali Mansoori*
Department of Bioengineering, University of Illinois, Chicago, USA
Corresponding author : Ali Mansoori G
Department of Bioengineering, University of Illinois, 851 S. Morgan St. (MC 063), Chicago, IL, 60607, USA
Tel: +1-312-996-5592
E-mail:
[email protected]
Received: February 27, 2013 Accepted: April 16, 2013 Published: April 29, 2013
Citation: Hartung GA, Mansoori GA (2013) In vivo General Trends, Filtration and Toxicity of Nanoparticles. J Nanomater Mol Nanotechnol 2:3. doi:10.4172/2324-8777.1000113

Abstract

In vivo General Trends, Filtration and Toxicity of Nanoparticles

The medical field is a vastly expanding one and with the discovery of nanoparticles (carbon nanotubes, diamondoids, fullerenes, gold and silver nanoparticles, quantum dots, etc.), there lies a vast field of unsolved medical diagnoses to be reassessed. Upon reassessment of the current medical problems, it is important to know what happens to a particle once it is free in the body. This review examines the different destinations of nanomaterials after they enter the body, their toxicity and their filtration. Assessing the destination of nanoparticles is done in order to find out whether they are removed by macrophages. It is concluded the strongest trends of the nanoparticles itself is of shape and surface chemistry. Toxicity of nanoparticles is found to be mostly dose-dependent. The nanoparticle filtration goal is to have the body naturally filter out the nanoparticles without a response from the immune system.

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