Research Article, J Mar Biol Oceanogr Vol: 3 Issue: 4
Antileishmanial Potential of Chondrococcus hornemanni against Experimental Visceral Leishmaniasis
| Vijai Lakshmi1*, Prashant Khare2, Pragya Misra2, Srivastava MN3 and Anuradha Dube2 | |
| 1Divisions of Medicinal & Process Chemistry, CSIR- Central Drug Research Institute, Lucknow, India | |
| 1Division of Parasitology, CSIR- Central Drug Research Institute, Lucknow, India | |
| 3Division of Botany, CSIR- Central Drug Research Institute, Lucknow, India | |
| Corresponding author : Vijai Lakshmi Department of Biochemistry, King George’s Medical University, Lucknow, India Tel: +91-(0522)–2254604 E-mail: vijlakshmius@yahoo.com |
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| Received: April 17, 2014 Accepted: August 30, 2014 Published: September 05, 2014 | |
| Citation: Lakshmi V, Khare P, Misra P, Srivastava MN, Dube A (2014) Antileishmanial Potential of Chondrococcus hornemanni against Experimental Visceral Leishmaniasis. J Mar Biol Oceanogr 3:4. doi:10.4172/2324-8661.1000137 |
Abstract
Antileishmanial Potential of Chondrococcus hornemanni against Experimental Visceral Leishmaniasis
Exploration of safe and effective antileishmanials from natural resources is an active area of research. Therefore we have selected C. hornemanni to evaluate its antileishmanial potential. The crude ethanol extract and its fractions were tested both in vitro and in vivo. The crude ethanol extract yielded almost (88.0 ± 6.9% inhibition of promastigotes and 75.8 ± 5.2% inhibition of intracellular amastigotes at 100 μg/ml concentration with IC50 values of 29.5 μg/ml and 40.6 μg/ml, respectively.
