Research Article, Int J Ophthalmic Pathol Vol: 5 Issue: 4
Cyclooxygenase Expression in Conjunctival Squamous Cell Carcinoma
| Capiz Correa D1*, Robles-Contreras A2, Tejeda-Rojas G1 and Sanchez Moreno F3 | |
| 1Medical Staff Member of the Orbit and Occuloplastics department at Foundation Hospital Nuestra Señora de la Luz IAP, Mexico City, Mexico | |
| 2Chief Researcher at Health Sciences Research Department at Foundation Hospital Nuestra Señora de la Luz IAP, Mexico City, Mexico | |
| 3Second year resident of Ophthalmology at Foundation Hospital Nuestra Señora de la Luz IAP, Mexico City, Mexico | |
| Corresponding author : Capiz Correa D Medical Staff Member of the Orbit and Occuloplastics department at Foundation Hospital Nuestra Señora de la Luz IAP, Mexico City, Mexico Tel: +55 51 28 11 40 E-mail: dr.capiz@hotmail.com |
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| Received: September 29, 2016 Accepted: November 11, 2016 Published: November 17, 2016 | |
| Citation: Capiz Correa D, Robles-Contreras A, Tejeda-Rojas G, Sanchez Moreno F (2016) Cyclooxygenase Expression in Conjunctival Squamous Cell Carcinoma. Int J Ophthalmic Pathol 5:4. doi: 10.4172/2324-8599.1000190 |
Abstract
Purpose: To determine cyclooxygenase 1 and cyclooxygenase 2 expression in conjunctival squamous cell carcinoma.
Methods: Prospective experimental case series of 24 tissue samples diagnosed with squamous cell carcinoma between 2010 and 2012 at Foundation Hospital Nuestra Señora de la Luz and determine cyclooxygenase 1 and 2 expression.
Results: 24 slides with diagnosis of conjunctival squamous cell carcinoma were processed; 50% from male patients and 50% from female patients. From the 24 samples; 23 rendered primary CSCC and 1 recurrent CSCC. In all of the samples, COX-2 and COX-1 were expressed, although these did not correlate to the level of invasion and grade of differentiation.
Conclusions: We found the expression of COX-1 to be a predominant marker in conjunctival tissue. COX-2 expression was found in higher levels at zones or borders of the tumor; as confirmed by an histopathological result of squamous cell carcinoma.
