Research Article, J Immunol Tech Infect Dis Vol: 2 Issue: 4
In vivo Evaluation of Antimalarial and Cytotoxic Properties of Crude Aqueous Extract of the Fruiting Body of Medicinal Mushroom, Ganoderma lucidum (W.Curt.:Fr.) P. Karst in Plasmodium berghei-Infected Mice
| Olarewaju M Oluba1,4*, George O Eidangbe2, Kayode E Adebisi3,4, Adewale A Odutuga1 and E Chukwu Onyeneke4 | |
| 1Department of Biochemistry, College of Natural Science, Joseph Ayo Babalola University, Ikeji-Arakeji, Osun State, Nigeria | |
| 2Department of Medical Biochemistry, College of Medicine, Ambrose Alli University, Ekpoma, Nigeria | |
| 3Department of Biochemistry, College of Pure & Applied Sciences, Kwara State University, Malete, Kwara State, Nigeria | |
| 4Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin-City, Nigeria | |
| Corresponding author : Dr. Olarewaju M Oluba Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin-City, Nigeria Tel: +2347030496639 E-mail: olubamike2000@yahoo.co.uk |
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| Received: August 02, 2013 Accepted: October 08, 2013 Published: October 14, 2013 | |
| Citation: Oluba OM, Eidangbe GO, Adebisi KE, Odutuga AA, Onyeneke EC (2013) In Vivo Evaluation of Antimalarial and Cytotoxic Properties of Crude Aqueous Extract of the Fruiting Body of Medicinal Mushroom, Ganoderma lucidum (W.Curt.:Fr.) P. Karst in Plasmodium berghei-Infected Mice. J Immunol Tech Infect Dis 2:4. doi: 10.4172/2329-9541.1000116 |
Abstract
In vivo Evaluation of Antimalarial and Cytotoxic Properties of Crude Aqueous Extract of the Fruiting Body of Medicinal Mushroom, Ganoderma lucidum (W.Curt.:Fr.) P. Karst in Plasmodium berghei-Infected Mice
This study was aimed at investigating the in vivo antimalarial and cytotoxic activities of crude aqueous extracts of the fruiting bodies of Ganoderma lucidum, a mushroom with well established medicinal properties. Plasmodium berghei (1×107) was inoculated intraperitoneally into Swiss albino mice. The extract was then administered by an intra gastric tube once daily for four days starting from the day of parasite inoculation. Chloroquine (CQ) (used as standard drug), was administered through the same route.
