Research Article, J Forensic Toxicol Pharmacol Vol: 5 Issue: 2
Mitochondrial Inhibitors and Alteration in Bioenergetics-the Dose makes the Poison
| David H Jang1*, Meghan B Spyres2, Alycia Valente1, Betty C Chen3 and Lance B Becker1 | |
| 1Department of Emergency Medicine, University of Pennsylvania Perelman School of Medicine, USA | |
| 2Banner-University Medical Center Phoenix, USA | |
| 3Division of Emergency Medicine, University of Washington, USA | |
| Corresponding author : David H Jang Department of Emergency Medicine, National Heart, Lung, and Blood Institute (NHLBI) K12 Scholar, USA Tel:646 509 7251 Fax: 215.662.3953 E-mail: david.jang@uphs.upenn.edu |
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| Received: June 15, 2016 Accepted: July 27, 2016 Published: August 05, 2016 | |
| Citation: Jang DH, Spyres MB, Valente A, Chen BC, Becker LB (2016) Mitochondrial Inhibitors and Alteration in Bioenergetics-the Dose makes the Poison. J Forensic Toxicol Pharmacol 5:2. doi:10.4172/2325-9841.1000146 |
Abstract
Mitochondrial inhibitors such as hydrogen sulfide and cyanide have traditional been associated as a poison due to its ability to interfere with mitochondrial respiration resulting in decreased mitochondrial bioenergetics leading to cellular failure. While on one side of the spectrum these mitochondrial inhibitors are poisonous there is also a potential protective aspect of these inhibitors currently being explored, particular to prevent ischemic-reperfusion injuries related to reactive oxygen species and the ability to decrease metabolic demand similar to what is described as “hibernation” or “suspended animation.”
