The Journal of Pharmacological & Biomedical Analysis (JPBMA) promotes rigorous research that makes a significant contribution in advancing knowledge on Pharmacological and biomedical analysis. JPBMA includes all major themes pertaining to pharmaceutical research.
Journal of Pharmacological & Biomedical Analysis is a subscription based journal that provides a range of options to purchase our articles and also permits unlimited Internet Access to complete Journal content. It accepts research, review papers, online letters to the editors & brief comments on previously published articles or other relevant findings in SciTechnol. Articles submitted by authors are evaluated by a group of peer review experts in the field and ensures that the published articles are of high quality, reflect solid scholarship in their fields, and that the information they contain is accurate and reliable.
The Sterol Regulatory Element Binding Transcription Factor 1 (SREBP1): An Attractive Therapeutic Target in CNS Drug Discoveries
Sterol regulatory element binding proteins (SREBPs) are endoplasmic reticulum (ER) residing transcription factors best known for their roles in regulation of genes mostly involved in the lipid biogenesis and metabolism in the liver and adipose tissues. This family of lipid transcription factors consists of SREBP1a, SREBP1c, and SREBP2.
Precise and critical analysis of biomedical data is crucial in our understanding of the pathological metabolism and necessary elements in the progress of a new drug development. Therefore this new open access journal (Journal of Pharmacological & Biomedical Analysis) is an important and welcome initiative for a new communication platform of research community allowing the rapid exchange of the scientific data.
Are Both Antidepressant Drug Effects and Test Scores Unspecific?
Background: Disappointingly small clinical effects of antidepressant drugs have recently been reemphasized. It is also unclear to what degree the 17 questions in the Hamilton Rating Scale of Depression and other questionnaires represent true aspects of depression or rather can be said to measure unspecific symptoms.
Methods: Within all clinical study reports concerning citalopram submitted to the Danish Health Authorities before registration in 1988 we identified among 49 studies two studies with placebo groups reporting individual patient scores. A multiple regression analysis was performed by treating questionnaire item no 1 (depressed mood) as the dependent variable and the scores for all other items as potentially explanatory variables. The questionnaire items were sorted in two groups: items with p-value less than 0.05 considered related to depression and items with p-value above 0.05 considered unrelated. By pooling the data together we performed an analysis of the effect size (standardized differences in means; citalopram versus placebo treatment, baseline score minus end score) for each of the two questionnaire groups, as well as for the total HAM-D 17 score.
Availability of Different Strengths of Anti Malarial Preparations in Pakistan: Implication for Patient Safety
Pakistan is among the moderately malaria endemic countries and malaria is the second most commonly reported diseases from public sector healthcare facilities. Few of the key factors in controlling malaria and reducing related morbidity and mortality rate includes early diagnosis, appropriate treatment and good quality patient care services. But, polypharmacy, peer influence, patient demands, lack of appropriate diagnosis and treatment based on clinical impression and self-medication are few of the most important factors leading towards irrational drug use in Pakistan. Malaria is usually diagnosed through clinical impression, and most presenting fever cases are suspected and treated for malaria without any evidence of malaria parasitaemia in Pakistan.