Research Article, J Womens Health Issues Care Vol: 2 Issue: 1
A Randomized Controlled Trial of the Effects of Retinyl Palmitate on CD4+ T Cell Related Cytokines, Thyroid Function and Metabolic Biomarkers in Obesity: A Study Design and Protocol
| Mahdieh Abbasalizad Farhangi1, Ali-Akbar Saboor- Yaraghi2, Mohammadreza Eshraghian3, Alireza Ostadrahimi4 and Seyyed-Ali Keshavarz5* | |
| 1Department of Community Nutrition, School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran | |
| 2Department of Cellular and Molecular Nutrition, School of Nutrition and Dietetics, Tehran University of Medical sciences, Tehran, Iran | |
| 3Faculty of Public Health, Department of Biostatistics and Epidemiology, Tehran University of Medical Sciences, Tehran, Iran | |
| 4Nutrition Research Center, School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran | |
| 5Department of Clinical Nutrition, School of Nutrition and Dietetics, Tehran University of Medical Sciences, Tehran, Iran | |
| Corresponding author : Seyyed-Ali Keshavarz Department of Clinical Nutrition, School of Nutrition and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Tel: +98 021 88954911; Fax: +98 021 88974462 Email: s_akeshavarz@yahoo.com |
|
| Received: December 06, 2012 Accepted: February 04, 2013 Published: February 08, 2013 | |
| Citation: Farhangi MA, Saboor-Yaraghi AA , Eshraghian M, Ostadrahimi A, Keshavarz SA (2013) A Randomized Controlled Trial of the Effects of Retinyl Palmitate on CD4+ T Cell Related Cytokines, Thyroid Function and Metabolic Biomarkers in Obesity: A Study Design and Protocol. J Womens Health, Issues Care 2:1. doi:10.4172/2325-9795.1000102 |
Abstract
A Randomized Controlled Trial of the Effects of Retinyl Palmitate on CD4+ T Cell Related Cytokines, Thyroid Function and Metabolic Biomarkers in Obesity: A Study Design and Protocol
Obesity, as a low grade chronic inflammatory condition, is associated with immune system dysfunction and several autoimmune diseases. Recent evidence demonstrates a pathogenic role for T-helper cells in developing obesity related immune-disorders. Vitamin A and its retinoid derivates are best known for their immune-regulatory effects. However, the effect of vitamin A supplementation on immune function in obese individuals is still unknown. The aim of the present study is to investigate the possible role of vitamin A supplementation on serum T-helper cytokines and several other secondary outcomes (anthropometric and metabolic parameters and thyroid function) in healthy obese reproductive age women
