International Publisher of Science, Technology and Medicine

Journal of Liver: Disease & Transplantation

Research Article

Sorafenib and Mammalian Target of Rapamycin Inhibitors after Liver Transplantation: A Single-Center Experience and Review of the Literature

Damiano Patrono1, Stefano Mirabella1, Elisabetta Magra1, Marco Palisi1, Renato Romagnoli1 and Mauro Salizzoni1,2*
1General Surgery 2U and Liver Transplantation Center, A.O. Città della Salute e della Scienza, Molinette Hospital, Corso Bramante 88-90-10126, Turin, Italy
2Professor of Surgery, University of Turin, Turin, Italy
Corresponding author : Prof. Mauro Salizzoni
Head of General Surgery 2U – Liver Transplantation Center, A. O. Città della Salute e della Scienza di Torino, University of Torino, Corso Bramante 88- 90, 10126, Torino, Italy
Tel: 00390116334374; Fax: 00390116336770
E-mail: mauro.salizzoni@unito.it
Received: February 13, 2014 Accepted: June 20, 2014 Published: June 25, 2014
Citation: Patrono D, Mirabella S, Magra E, Palisi M, Romagnoli R (2014) Sorafenib and Mammalian Target of Rapamycin Inhibitors after Liver Transplantation: A Single-Center Experience and Review of the Literature. J Liver: Dis Transplant 3:1. doi:10.4172/2325-9612.1000119

Abstract

Sorafenib and Mammalian Target of Rapamycin Inhibitors after Liver Transplantation: A
Single-Center Experience and Review of the Literature

Hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) is observed in 10-15% of the patients and generally has a dismal prognosis. Little is known about the safety and efficacy of a therapeutic regimen including sorafenib and mammalian target of rapamycin inhibitors (mTORi) in this setting. The medical charts of the recipients of a LT presenting HCC recurrence and treated with sorafenib either alone
or in combination with mTORi were retrospectively reviewed.

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