����JFIFXX�����    $.' ",#(7),01444'9=82<.342  2!!22222222222222222222222222222222222222222222222222����"��4�� ���,�PG"Z_�4�˷����kjز�Z�,F+��_z�,�© �����zh6�٨�ic�fu���#ډb���_�N�?��wQ���5-�~�I���8����TK<5o�Iv-�����k�_U_�����~b�M��d����Ӝ�U�Hh��?]��E�w��Q���k�{��_}qFW7HTՑ��Y��F�?_�'ϔ��_�Ջt��=||I ��6�έ"�����D���/[�k�9���Y�8ds|\���Ҿp6�Ҵ���]��.����6�z<�v��@]�i%��$j��~�g��J>��no����pM[me�i$[����s�o�ᘨ�˸ nɜG-�ĨU�ycP�3.DB�li�;��hj���x7Z^�N�h������N3u{�:j�x�힞��#M&��jL P@_���� P��&��o8������9�����@Sz6�t7#O�ߋ �s}Yf�T���lmr����Z)'N��k�۞p����w\�Tȯ?�8`�O��i{wﭹW�[�r�� ��Q4F�׊���3m&L�=��h3����z~��#�\�l :�F,j@�� ʱ�wQT����8�"kJO���6�֚l����}���R�>ډK���]��y����&����p�}b��;N�1�m�r$�|��7�>e�@B�TM*-iH��g�D�)� E�m�|�ؘbҗ�a��Ҿ����t4���o���G��*oCN�rP���Q��@z,|?W[0�����:�n,jWiE��W��$~/�hp\��?��{(�0���+�Y8rΟ�+����>S-S����VN;�}�s?.����� w�9��˟<���Mq4�Wv'��{)0�1mB��V����W[�����8�/<� �%���wT^�5���b��)iM� pg�N�&ݝ��VO~�q���u���9� ����!��J27����$O-���! �:�%H��� ـ����y�ΠM=t{!S�� oK8������t<����è:a������[�����ա�H���~��w��Qz`�po�^ ����Q��n� �,uu�C�$ ^���,������8�#��:�6��e�|~���!�3�3.�\0��q��o�4`.|� ����y�Q�`~;�d�ׯ,��O�Zw�������`73�v�܋�<���Ȏ�� ـ4k��5�K�a�u�=9Yd��$>x�A�&�� j0� ���vF��� Y�|�y��� ~�6�@c��1vOp�Ig����4��l�OD���L����� R���c���j�_�uX6��3?nk��Wy�f;^*B� ��@�~a�`��Eu������+���6�L��.ü>��}y���}_�O�6�͐�:�YrG�X��kG�����l^w���~㒶sy��Iu�!� W ��X��N�7BV��O��!X�2����wvG�R�f�T#�����t�/?���%8�^�W�aT��G�cL�M���I��(J����1~�8�?aT ���]����AS�E��(��*E}� 2��#I/�׍qz��^t�̔���b�Yz4x���t�){ OH��+(E��A&�N�������XT��o��"�XC��'���)}�J�z�p� ��~5�}�^����+�6����w��c��Q�|Lp�d�H��}�(�.|����k��c4^�"�����Z?ȕ ��a<�L�!039C� �Eu�C�F�Ew�ç ;�n?�*o���B�8�bʝ���'#Rqf���M}7����]����s2tcS{�\icTx;�\��7K���P���ʇ Z O-��~��c>"��?�������P��E��O�8��@�8��G��Q�g�a�Վ���󁶠�䧘��_%#r�>�1�z�a��eb��qcPѵ��n���#L��� =��׀t� L�7�`��V���A{�C:�g���e@�w1 Xp3�c3�ġ����p��M"'-�@n4���fG��B3�DJ�8[Jo�ߐ���gK)ƛ��$���� ���8�3�����+���� �����6�ʻ���� ���S�kI�*KZlT _`���?��K����QK�d����B`�s}�>���`��*�>��,*@J�d�oF*����弝��O}�k��s��]��y�ߘ��c1G�V���<=�7��7����6�q�PT��tXԀ�!9*4�4Tހ3XΛex�46���Y��D ����� �BdemDa����\�_l,��G�/���֌7���Y�](�xTt^%�GE�����4�}bT���ڹ�����;Y)���B�Q��u��>J/J �⮶.�XԄ��j�ݳ�+E��d ��r�5�_D�1 ��o�� �B�x�΢�#���<��W�����8���R6�@g�M�.��� dr�D��>(otU��@x=��~v���2� ӣ�d�oBd��3�eO�6�㣷�����ݜ6��6Y��Qz`��S��{���\P�~z m5{J/L��1������<�e�ͅPu�b�]�ϔ���'������f�b� Zpw��c`"��i���BD@:)ִ�:�]��hv�E�w���T�l��P���"Ju�}��وV J��G6��. J/�Qgl߭�e�����@�z�Zev2u�)]կ�����7x���s�M�-<ɯ�c��r�v�����@��$�ޮ}lk���a���'����>x��O\�ZFu>�����ck#��&:��`�$�ai�>2Δ����l���oF[h��lE�ܺ�Πk:)���`�� $[6�����9�����kOw�\|���8}������ބ:��񶐕��I�A1/�=�2[�,�!��.}gN#�u����b��� ~��݊��}34q����d�E��Lc��$��"�[q�U�硬g^��%B �z���r�pJ�ru%v\h1Y�ne`ǥ:g���pQM~�^�Xi� ��`S�:V29.�P���V�?B�k�� AEvw%�_�9C�Q����wKekPؠ�\�;Io d�{ ߞo�c1eP����\� `����E=���@K<�Y���eڼ�J���w����{av�F�'�M�@/J��+9p���|]�����Iw &`��8���&M�hg��[�{��Xj��%��Ӓ�$��(����ʹN���<>�I���RY���K2�NPlL�ɀ)��&e����B+ь����( � �JTx���_?EZ� }@ 6�U���뙢ط�z��dWI�n` D����噥�[��uV��"�G&Ú����2g�}&m��?ċ�"����Om#��������� ��{�ON��"S�X��Ne��ysQ���@Fn��Vg���dX�~nj�]J�<�K]:��FW��b�������62�=��5f����JKw��bf�X�55��~J �%^����:�-�QIE��P��v�nZum� z � ~ə ���� ���ة����;�f��\v���g�8�1��f24;�V���ǔ�)����9���1\��c��v�/'Ƞ�w�������$�4�R-��t���� e�6�/�ġ �̕Ecy�J���u�B���<�W�ַ~�w[B1L۲�-JS΂�{���΃������A��20�c#��@ 0!1@AP"#2Q`$3V�%45a6�FRUq��� ����^7ׅ,$n�������+��F�`��2X'��0vM��p�L=������5��8������u�p~���.�`r�����\���O��,ư�0oS ��_�M�����l���4�kv\JSd���x���SW�<��Ae�IX����������$I���w�:S���y���›R��9�Q[���,�5�;�@]�%���u�@ *ro�lbI �� ��+���%m:�͇ZV�����u�̉����θau<�fc�.����{�4Ա� �Q����*�Sm��8\ujqs]{kN���)qO�y�_*dJ�b�7���yQqI&9�ԌK!�M}�R�;������S�T���1���i[U�ɵz�]��U)V�S6���3$K{�ߊ<�(� E]Զ[ǼENg�����'�\?#)Dkf��J���o��v���'�%ƞ�&K�u�!��b�35LX�Ϸ��63$K�a�;�9>,R��W��3�3� d�JeTYE.Mϧ��-�o�j3+y��y^�c�������VO�9NV\nd�1 ��!͕_)a�v;����թ�M�lWR1��)El��P;��yوÏ�u 3�k�5Pr6<�⒲l�!˞*��u־�n�!�l:����UNW ��%��Chx8vL'��X�@��*��)���̮��ˍ��� ���D-M�+J�U�kvK����+�x8��cY������?�Ԡ��~3mo��|�u@[XeY�C�\Kp�x8�oC�C�&����N�~3-H���� ��MX�s�u<`���~"WL��$8ξ��3���a�)|:@�m�\���^�`�@ҷ)�5p+��6���p�%i)P M���ngc�����#0Aruz���RL+xSS?���ʮ}()#�t��mˇ!��0}}y����<�e� �-ή�Ԩ��X������ MF���ԙ~l L.3���}�V뽺�v�����멬��Nl�)�2����^�Iq��a��M��qG��T�����c3#������3U�Ǎ���}��לS�|qa��ڃ�+���-��2�f����/��bz��ڐ�� �ݼ[2�ç����k�X�2�* �Z�d���J�G����M*9W���s{��w���T��x��y,�in�O�v��]���n����P�$�JB@=4�OTI�n��e�22a\����q�d���%�$��(���:���: /*�K[PR�fr\nڙdN���F�n�$�4�[�� U�zƶ����� �mʋ���,�ao�u 3�z� �x��Kn����\[��VFmbE;�_U��&V�Gg�]L�۪&#n%�$ɯ�dG���D�TI=�%+AB�Ru#��b4�1�»x�cs�YzڙJG��f��Il��d�eF'T� iA��T���uC�$����Y��H?����[!G`}���ͪ� �纤Hv\������j�Ex�K���!���OiƸ�Yj�+u-<���'q����uN�*�r\��+�]���<�wOZ.fp�ێ��,-*)V?j-kÊ#�`�r��dV����(�ݽBk�����G�ƛk�QmUڗe��Z���f}|����8�8��a���i��3'J�����~G_�^���d�8w������ R�`(�~�.��u���l�s+g�bv���W���lGc}��u���afE~1�Ue������Z�0�8�=e�� f@/�jqEKQQ�J��oN��J���W5~M>$6�Lt�;$ʳ{���^��6�{����v6���ķܰg�V�cnn �~z�x�«�,2�u�?cE+Ș�H؎�%�Za�)���X>uW�Tz�Nyo����s���FQƤ��$��*�&�LLXL)�1�" L��eO��ɟ�9=���:t��Z���c��Ž���Y?�ӭV�wv�~,Y��r�ۗ�|�y��GaF�����C�����.�+� ���v1���fήJ�����]�S��T��B��n5sW}y�$��~z�'�c ��8 ��� ,! �p��VN�S��N�N�q��y8z˱�A��4��*��'������2n<�s���^ǧ˭P�Jޮɏ�U�G�L�J�*#��<�V��t7�8����TĜ>��i}K%,���)[��z�21z ?�N�i�n1?T�I�R#��m-�����������������1����lA�`��fT5+��ܐ�c�q՝��ʐ��,���3�f2U�եmab��#ŠdQ�y>\��)�SLY����w#��.���ʑ�f��� ,"+�w�~�N�'�c�O�3F�������N<���)j��&��,-� �љ���֊�_�zS���TǦ����w�>��?�������n��U仆�V���e�����0���$�C�d���rP �m�׈e�Xm�Vu� �L��.�bֹ��� �[Դaզ���*��\y�8�Է:�Ez\�0�Kq�C b��̘��cө���Q��=0Y��s�N��S.���3.���O�o:���#���v7�[#߫ ��5�܎�L���Er4���9n��COWlG�^��0k�%<���ZB���aB_���������'=��{i�v�l�$�uC���mƎҝ{�c㱼�y]���W�i ��ߧc��m�H� m�"�"�����;Y�ߝ�Z�Ǔ�����:S#��|}�y�,/k�Ld� TA�(�AI$+I3��;Y*���Z��}|��ӧO��d�v��..#:n��f>�>���ȶI�TX��� 8��y����"d�R�|�)0���=���n4��6ⲑ�+��r<�O�܂~zh�z����7ܓ�HH�Ga롏���nCo�>������a ���~]���R���̲c?�6(�q�;5%� |�uj�~z8R=X��I�V=�|{v�Gj\gc��q����z�؋%M�ߍ����1y��#��@f^���^�>N�����#x#۹��6�Y~�?�dfPO��{��P�4��V��u1E1J �*|���%���JN��`eWu�zk M6���q t[�� ��g�G���v��WIG��u_ft����5�j�"�Y�:T��ɐ���*�;� e5���4����q$C��2d�}���� _S�L#m�Yp��O�.�C�;��c����Hi#֩%+) �Ӎ��ƲV���SYź��g |���tj��3�8���r|���V��1#;.SQ�A[���S������#���`n�+���$��$I �P\[�@�s��(�ED�z���P��])8�G#��0B��[ى��X�II�q<��9�~[Z멜�Z�⊔IWU&A>�P~�#��dp<�?����7���c��'~���5 ��+$���lx@�M�dm��n<=e�dyX��?{�|Aef ,|n3�<~z�ƃ�uۧ�����P��Y,�ӥQ�*g�#먙R�\���;T��i,��[9Qi歉����c>]9�� ��"�c��P�� �Md?٥��If�ت�u��k��/����F��9�c*9��Ǎ:�ØF���z�n*�@|I�ށ9����N3{'��[�'ͬ�Ҳ4��#}��!�V� Fu��,�,mTIk���v C�7v���B�6k�T9��1�*l� '~��ƞF��lU��'�M ����][ΩũJ_�{�i�I�n��$���L�� j��O�dx�����kza۪��#�E��Cl����x˘�o�����V���ɞ�ljr��)�/,�߬h�L��#��^��L�ф�,íMƁe�̩�NB�L�����iL����q�}��(��q��6IçJ$�W�E$��:������=#����(�K�B����zђ <��K(�N�۫K�w��^O{!����)�H���>x�������lx�?>Պ�+�>�W���,Ly!_�D���Ō�l���Q�!�[ �S����J��1��Ɛ�Y}��b,+�Lo�x�ɓ)����=�y�oh�@�꥟/��I��ѭ=��P�y9��� �ۍYӘ�e+�p�Jnϱ?V\SO%�(�t� ���=?MR�[Ș�����d�/ ��n�l��B�7j� ��!�;ӥ�/�[-���A�>�dN�sLj ��,ɪv��=1c�.SQ�O3�U���ƀ�ܽ�E����������̻��9G�ϷD�7(�}��Ävӌ\�y�_0[w ���<΍>����a_��[0+�L��F.�޺��f�>oN�T����q;���y\��bՃ��y�jH�<|q-eɏ�_?_9+P���Hp$�����[ux�K w�Mw��N�ی'$Y2�=��q���KB��P��~������Yul:�[<����F1�2�O���5=d����]Y�sw:���Ϯ���E��j,_Q��X��z`H1,#II ��d�wr��P˂@�ZJV����y$�\y�{}��^~���[:N����ߌ�U�������O��d�����ؾe��${p>G��3c���Ė�lʌ�� ת��[��`ϱ�-W����dg�I��ig2��� ��}s ��ؤ(%#sS@���~���3�X�nRG�~\jc3�v��ӍL��M[JB�T��s3}��j�Nʖ��W����;7��ç?=X�F=-�=����q�ߚ���#���='�c��7���ڑW�I(O+=:uxq�������������e2�zi+�kuG�R��������0�&e�n���iT^J����~\jy���p'dtG��s����O��3����9* �b#Ɋ�� p������[Bws�T�>d4�ۧs���nv�n���U���_�~,�v����ƜJ1��s�� �QIz��)�(lv8M���U=�;����56��G���s#�K���MP�=��LvyGd��}�VwWBF�'�à �?MH�U�g2�� ����!�p�7Q��j��ڴ����=��j�u��� Jn�A s���uM������e��Ɔ�Ҕ�!)'��8Ϣ�ٔ��ޝ(��Vp���צ֖d=�IC�J�Ǡ{q������kԭ�߸���i��@K����u�|�p=..�*+����x�����z[Aqġ#s2a�Ɗ���RR�)*HRsi�~�a &f��M��P����-K�L@��Z��Xy�'x�{}��Zm+���:�)�) IJ�-i�u���� ���ܒH��'�L(7�y�GӜq���� j��� 6ߌg1�g�o���,kر���tY�?W,���p���e���f�OQS��!K�۟cҒA�|ս�j�>��=⬒��˧L[�� �߿2JaB~R��u�:��Q�] �0H~���]�7��Ƽ�I���(}��cq '�ήET���q�?f�ab���ӥvr� �)o��-Q��_'����ᴎo��K������;��V���o��%���~OK ����*��b�f:���-ťIR��`B�5!RB@���ï�� �u �̯e\�_U�_������� g�ES��3�������QT��a����x����U<~�c?�*�#]�MW,[8O�a�x��]�1bC|踤�P��lw5V%�)�{t�<��d��5���0i�XSU��m:��Z�┵�i�"��1�^B�-��P�hJ��&)O��*�D��c�W��vM��)����}���P��ܗ-q����\mmζZ-l@�}��a��E�6��F�@��&Sg@���ݚ�M����� ȹ 4����#p�\H����dYDo�H���"��\��..R�B�H�z_�/5˘����6��KhJR��P�mƶi�m���3�,#c�co��q�a)*Pt����R�m�k�7x�D�E�\Y�閣_X�<���~�)���c[[�BP����6�Yq���S��0����%_����;��Àv�~�| VS؇ ��'O0��F0��\���U�-�d@�����7�SJ*z��3n��y��P����O���������m�~�P�3|Y��ʉr#�C�<�G~�.,! ���bqx���h~0=��!ǫ�jy����l�O,�[B��~��|9��ٱ����Xly�#�i�B��g%�S��������tˋ���e���ې��\[d�t)��.+u�|1 ������#�~Oj����hS�%��i.�~X���I�H�m��0n���c�1uE�q��cF�RF�o���7� �O�ꮧ� ���ۛ{��ʛi5�rw?׌#Qn�TW��~?y$��m\�\o����%W� ?=>S�N@�� �Ʈ���R����N�)�r"C�:��:����� �����#��qb��Y�. �6[��2K����2u�Ǧ�HYR��Q�MV��� �G�$��Q+.>�����nNH��q�^��� ����q��mM��V��D�+�-�#*�U�̒ ���p욳��u:�������IB���m���PV@O���r[b= �� ��1U�E��_Nm�yKbN�O���U�}�the�`�|6֮P>�\2�P�V���I�D�i�P�O;�9�r�mAHG�W�S]��J*�_�G��+kP�2����Ka�Z���H�'K�x�W�MZ%�O�YD�Rc+o��?�q��Ghm��d�S�oh�\�D�|:W������UA�Qc yT�q������~^�H��/��#p�CZ���T�I�1�ӏT����4��"�ČZ�����}��`w�#�*,ʹ�� ��0�i��課�Om�*�da��^gJ݅{���l�e9uF#T�ֲ��̲�ٞC"�q���ߍ ոޑ�o#�XZTp����@ o�8��(jd��xw�]�,f���`~�|,s��^����f�1���t��|��m�򸄭/ctr��5s��7�9Q�4�H1꠲BB@l9@���C�����+�wp�xu�£Yc�9��?`@#�o�mH�s2��)�=��2�.�l����jg�9$�Y�S�%*L������R�Y������7Z���,*=�䷘$�������arm�o�ϰ���UW.|�r�uf����IGw�t����Zwo��~5 ��YյhO+=8fF�)�W�7�L9lM�̘·Y���֘YLf�큹�pRF���99.A �"wz��=E\Z���'a� 2��Ǚ�#;�'}�G���*��l��^"q��+2FQ� hj��kŦ��${���ޮ-�T�٭cf�|�3#~�RJ����t��$b�(R��(����r���dx� >U b�&9,>���%E\� Ά�e�$��'�q't��*�א���ެ�b��-|d���SB�O�O��$�R+�H�)�܎�K��1m`;�J�2�Y~9��O�g8=vqD`K[�F)k�[���1m޼c��n���]s�k�z$@��)!I �x՝"v��9=�ZA=`Ɠi �:�E��)`7��vI��}d�YI�_ �o�:ob���o ���3Q��&D&�2=�� �Ά��;>�h����y.*ⅥS������Ӭ�+q&����j|UƧ����}���J0��WW< ۋS�)jQR�j���Ư��rN)�Gű�4Ѷ(�S)Ǣ�8��i��W52���No˓� ۍ%�5brOn�L�;�n��\G����=�^U�dI���8$�&���h��'���+�(������cȁ߫k�l��S^���cƗjԌE�ꭔ��gF���Ȓ��@���}O���*;e�v�WV���YJ\�]X'5��ղ�k�F��b 6R�o՜m��i N�i����>J����?��lPm�U��}>_Z&�KK��q�r��I�D�Չ~�q�3fL�:S�e>���E���-G���{L�6p�e,8��������QI��h��a�Xa��U�A'���ʂ���s�+טIjP�-��y�8ۈZ?J$��W�P� ��R�s�]��|�l(�ԓ��sƊi��o(��S0��Y� 8�T97.�����WiL��c�~�dxc�E|�2!�X�K�Ƙਫ਼�$((�6�~|d9u+�qd�^3�89��Y�6L�.I�����?���iI�q���9�)O/뚅����O���X��X�V��ZF[�یgQ�L��K1���RҖr@v�#��X�l��F���Нy�S�8�7�kF!A��sM���^rkp�jP�DyS$N���q��nxҍ!U�f�!eh�i�2�m���`�Y�I�9r�6� �TF���C}/�y�^���Η���5d�'��9A-��J��>{�_l+�`��A���[�'��յ�ϛ#w:݅�%��X�}�&�PSt�Q�"�-��\縵�/����$Ɨh�Xb�*�y��BS����;W�ջ_mc�����vt?2}1�;qS�d�d~u:2k5�2�R�~�z+|HE!)�Ǟl��7`��0�<�,�2*���Hl-��x�^����'_TV�gZA�'j� ^�2Ϊ��N7t�����?w�� �x1��f��Iz�C-Ȗ��K�^q�;���-W�DvT�7��8�Z�������� hK�(P:��Q- �8�n�Z���܃e貾�<�1�YT<�,�����"�6{/ �?�͟��|1�:�#g��W�>$����d��J��d�B��=��jf[��%rE^��il:��B���x���Sּ�1հ��,�=��*�7 fcG��#q� �eh?��2�7�����,�!7x��6�n�LC�4x��},Geǝ�tC.��vS �F�43��zz\��;QYC,6����~;RYS/6���|2���5���v��T��i����������mlv��������&� �nRh^ejR�LG�f���? �ۉҬܦƩ��|��Ȱ����>3����!v��i�ʯ�>�v��オ�X3e���_1z�Kȗ\<������!�8���V��]��?b�k41�Re��T�q��mz��TiOʦ�Z��Xq���L������q"+���2ۨ��8}�&N7XU7Ap�d�X��~�׿��&4e�o�F��� �H����O���č�c�� 懴�6���͉��+)��v;j��ݷ�� �UV�� i��� j���Y9GdÒJ1��詞�����V?h��l����l�cGs�ځ�������y�Ac�����\V3�? �� ܙg�>qH�S,�E�W�[�㺨�uch�⍸�O�}���a��>�q�6�n6����N6�q������N ! 1AQaq�0@����"2BRb�#Pr���3C`��Scst���$4D���%Td�� ?���N����a��3��m���C���w��������xA�m�q�m���m������$����4n淿t'��C"w��zU=D�\R+w�p+Y�T�&�պ@��ƃ��3ޯ?�Aﶂ��aŘ���@-�����Q�=���9D��ռ�ѻ@��M�V��P��܅�G5�f�Y<�u=,EC)�<�Fy'�"�&�չ�X~f��l�KԆV��?�� �W�N����=(� �;���{�r����ٌ�Y���h{�١������jW����P���Tc�����X�K�r��}���w�R��%��?���E��m�� �Y�q|����\lEE4���r���}�lsI�Y������f�$�=�d�yO����p�����yBj8jU�o�/�S��?�U��*������ˍ�0������u�q�m [�?f����a�� )Q�>����6#������� ?����0UQ����,IX���(6ڵ[�DI�MNލ�c&���υ�j\��X�R|,4��� j������T�hA�e��^���d���b<����n�� �즇�=!���3�^�`j�h�ȓr��jẕ�c�,ٞX����-����a�ﶔ���#�$��]w�O��Ӫ�1y%��L�Y<�wg#�ǝ�̗`�x�xa�t�w��»1���o7o5��>�m뭛C���Uƃߜ}�C���y1Xνm�F8�jI���]����H���ۺиE@I�i;r�8ӭ����V�F�Շ| ��&?�3|x�B�MuS�Ge�=Ӕ�#BE5G�����Y!z��_e��q�р/W>|-�Ci߇�t�1ޯќd�R3�u��g�=0 5��[?�#͏��q�cf���H��{ ?u�=?�?ǯ���}Z��z���hmΔ�BFTW�����<�q�(v� ��!��z���iW]*�J�V�z��gX֧A�q�&��/w���u�gYӘa���; �i=����g:��?2�dž6�ى�k�4�>�Pxs����}������G�9��3 ���)gG�R<>r h�$��'nc�h�P��Bj��J�ҧH� -��N1���N��?��~��}-q!=��_2hc�M��l�vY%UE�@|�v����M2�.Y[|y�"Eï��K�ZF,�ɯ?,q�?v�M 80jx�"�;�9vk�����+ ֧�� �ȺU��?�%�vcV��mA�6��Qg^M����A}�3�nl� QRN�l8�kkn�'�����(��M�7m9و�q���%ޟ���*h$Zk"��$�9��: �?U8�Sl��,,|ɒ��xH(ѷ����Gn�/Q�4�P��G�%��Ա8�N��!� �&�7�;���eKM7�4��9R/%����l�c>�x;������>��C�:�����t��h?aKX�bhe�ᜋ^�$�Iհ �hr7%F$�E��Fd���t��5���+�(M6�t����Ü�UU|zW�=a�Ts�Tg������dqP�Q����b'�m���1{|Y����X�N��b �P~��F^F:����k6�"�j!�� �I�r�`��1&�-$�Bevk:y���#yw��I0��x��=D�4��tU���P�ZH��ڠ底taP��6����b>�xa����Q�#� WeF��ŮNj�p�J* mQ�N����*I�-*�ȩ�F�g�3 �5��V�ʊ�ɮ�a��5F���O@{���NX��?����H�]3��1�Ri_u��������ѕ�� ����0��� F��~��:60�p�͈�S��qX#a�5>���`�o&+�<2�D����: �������ڝ�$�nP���*)�N�|y�Ej�F�5ټ�e���ihy�Z �>���k�bH�a�v��h�-#���!�Po=@k̆IEN��@��}Ll?j�O������߭�ʞ���Q|A07x���wt!xf���I2?Z��<ץ�T���cU�j��]��陎Ltl �}5�ϓ��$�,��O�mˊ�;�@O��jE��j(�ا,��LX���LO���Ц�90�O �.����a��nA���7������j4 ��W��_ٓ���zW�jcB������y՗+EM�)d���N�g6�y1_x��p�$Lv:��9�"z��p���ʙ$��^��JԼ*�ϭ����o���=x�Lj�6�J��u82�A�H�3$�ٕ@�=Vv�]�'�qEz�;I˼��)��=��ɯ���x �/�W(V���p�����$ �m�������u�����񶤑Oqˎ�T����r��㠚x�sr�GC��byp�G��1ߠ�w e�8�$⿄����/�M{*}��W�]˷.�CK\�ުx���/$�WPw���r� |i���&�}�{�X� �>��$-��l���?-z���g����lΆ���(F���h�vS*���b���߲ڡn,|)mrH[���a�3�ר�[1��3o_�U�3�TC�$��(�=�)0�kgP���� ��u�^=��4 �WYCҸ:��vQ�ר�X�à��tk�m,�t*��^�,�}D*� �"(�I��9R����>`�`��[~Q]�#af��i6l��8���6�:,s�s�N6�j"�A4���IuQ��6E,�GnH��zS�HO�uk�5$�I�4��ؤ�Q9�@��C����wp�BGv[]�u�Ov���0I4���\��y�����Q�Ѹ��~>Z��8�T��a��q�ޣ;z��a���/��S��I:�ܫ_�|������>=Z����8:�S��U�I�J��"IY���8%b8���H��:�QO�6�;7�I�S��J��ҌAά3��>c���E+&jf$eC+�z�;��V����� �r���ʺ������my�e���aQ�f&��6�ND��.:��NT�vm�<- u���ǝ\MvZY�N�NT��-A�>jr!S��n�O 1�3�Ns�%�3D@���`������ܟ 1�^c<���� �a�ɽ�̲�Xë#�w�|y�cW�=�9I*H8�p�^(4���՗�k��arOcW�tO�\�ƍR��8����'�K���I�Q�����?5�>[�}��yU�ײ -h��=��% q�ThG�2�)���"ו3]�!kB��*p�FDl�A���,�eEi�H�f�Ps�����5�H:�Փ~�H�0Dت�D�I����h�F3�������c��2���E��9�H��5�zԑ�ʚ�i�X�=:m�xg�hd(�v����׊�9iS��O��d@0ڽ���:�p�5�h-��t�&���X�q�ӕ,��ie�|���7A�2���O%P��E��htj��Y1��w�Ѓ!����  ���� ࢽ��My�7�\�a�@�ţ�J �4�Ȼ�F�@o�̒?4�wx��)��]�P��~�����u�����5�����7X ��9��^ܩ�U;Iꭆ 5 �������eK2�7(�{|��Y׎ �V��\"���Z�1� Z�����}��(�Ǝ"�1S���_�vE30>���p;� ΝD��%x�W�?W?v����o�^V�i�d��r[��/&>�~`�9Wh��y�;���R��� ;;ɮT��?����r$�g1�K����A��C��c��K��l:�'��3 c�ﳯ*"t8�~l��)���m��+U,z��`(�>yJ�?����h>��]��v��ЍG*�{`��;y]��I�T� ;c��NU�fo¾h���/$���|NS���1�S�"�H��V���T���4��uhǜ�]�v;���5�͠x��'C\�SBpl���h}�N����� A�Bx���%��ޭ�l��/����T��w�ʽ]D�=����K���ž�r㻠l4�S�O?=�k �M:� ��c�C�a�#ha���)�ѐxc�s���gP�iG��{+���x���Q���I= �� z��ԫ+ �8"�k�ñ�j=|����c ��y��CF��/��*9ж�h{ �?4�o� ��k�m�Q�N�x��;�Y��4膚�a�w?�6�>e]�����Q�r�:����g�,i"�����ԩA�*M�<�G��b�if��l^M��5� �Ҩ�{����6J��ZJ�����P�*�����Y���ݛu�_4�9�I8�7���������,^ToR���m4�H��?�N�S�ѕw��/S��甍�@�9H�S�T��t�ƻ���ʒU��*{Xs�@����f�����֒Li�K{H�w^���������Ϥm�tq���s� ���ք��f:��o~s��g�r��ט� �S�ѱC�e]�x���a��) ���(b-$(�j>�7q�B?ӕ�F��hV25r[7 Y� }L�R��}����*sg+��x�r�2�U=�*'WS��ZDW]�WǞ�<��叓���{�$�9Ou4��y�90-�1�'*D`�c�^o?(�9��u���ݐ��'PI&� f�Jݮ�������:wS����jfP1F:X �H�9dԯ���˝[�_54 �}*;@�ܨ�� ð�yn�T���?�ןd�#���4rG�ͨ��H�1�|-#���Mr�S3��G�3�����)�.᧏3v�z֑��r����$G"�`j �1t��x0<Ɔ�Wh6�y�6��,œ�Ga��gA����y��b��)��h�D��ß�_�m��ü �gG;��e�v��ݝ�nQ� ��C����-�*��o���y�a��M��I�>�<���]obD��"�:���G�A��-\%LT�8���c�)��+y76���o�Q�#*{�(F�⽕�y����=���rW�\p���۩�c���A���^e6��K������ʐ�cVf5$�'->���ՉN"���F�"�UQ@�f��Gb~��#�&�M=��8�ט�JNu9��D��[̤�s�o�~������ G��9T�tW^g5y$b��Y'��س�Ǵ�=��U-2 #�MC�t(�i� �lj�@Q 5�̣i�*�O����s�x�K�f��}\��M{E�V�{�υ��Ƈ�����);�H����I��fe�Lȣr�2��>��W�I�Ȃ6������i��k�� �5�YOxȺ����>��Y�f5'��|��H+��98pj�n�.O�y�������jY��~��i�w'������l�;�s�2��Y��:'lg�ꥴ)o#'Sa�a�K��Z� �m��}�`169�n���"���x��I ��*+� }F<��cГ���F�P�������ֹ*�PqX�x۩��,� ��N�� �4<-����%����:��7����W���u�`����� $�?�I��&����o��o��`v�>��P��"��l���4��5'�Z�gE���8���?��[�X�7(��.Q�-��*���ތL@̲����v��.5���[��=�t\+�CNܛ��,g�SQnH����}*F�G16���&:�t��4ُ"A��̣��$�b �|����#rs��a�����T�� ]�<�j��BS�('$�ɻ� �wP;�/�n��?�ݜ��x�F��yUn�~mL*-�������Xf�wd^�a�}��f�,=t�׵i�.2/wpN�Ep8�OР���•��R�FJ� 55TZ��T �ɭ�<��]��/�0�r�@�f��V��V����Nz�G��^���7hZi����k��3�,kN�e|�vg�1{9]_i��X5y7� 8e]�U����'�-2,���e"����]ot�I��Y_��n�(JҼ��1�O ]bXc���Nu�No��pS���Q_���_�?i�~�x h5d'�(qw52] ��'ޤ�q��o1�R!���`ywy�A4u���h<קy���\[~�4�\ X�Wt/� 6�����n�F�a8��f���z �3$�t(���q��q�x��^�XWeN'p<-v�!�{�(>ӽDP7��ո0�y)�e$ٕv�Ih'Q�EA�m*�H��RI��=:��� ���4牢) �%_iN�ݧ�l]� �Nt���G��H�L��� ɱ�g<���1V�,�J~�ٹ�"K��Q�� 9�HS�9�?@��k����r�;we݁�]I�!{ �@�G�[�"��`���J:�n]�{�cA�E����V��ʆ���#��U9�6����j�#Y�m\��q�e4h�B�7��C�������d<�?J����1g:ٳ���=Y���D�p�ц� ׈ǔ��1�]26؜oS�'��9�V�FVu�P�h�9�xc�oq�X��p�o�5��Ա5$�9W�V(�[Ak�aY錎qf;�'�[�|���b�6�Ck��)��#a#a˙��8���=äh�4��2��C��4tm^ �n'c���]GQ$[Wҿ��i���vN�{Fu ��1�gx��1┷���N�m��{j-,��x�� Ūm�ЧS�[�s���Gna���䑴�� x�p 8<������97�Q���ϴ�v�aϚG��Rt�Һ׈�f^\r��WH�JU�7Z���y)�vg=����n��4�_)y��D'y�6�]�c�5̪�\� �PF�k����&�c;��cq�$~T�7j ���nç]�<�g ":�to�t}�159�<�/�8������m�b�K#g'I'.W�����6��I/��>v��\�MN��g���m�A�yQL�4u�Lj�j9��#44�t��l^�}L����n��R��!��t��±]��r��h6ٍ>�yҏ�N��fU�� ���� Fm@�8}�/u��jb9������he:A�y�ծw��GpΧh�5����l}�3p468��)U��d��c����;Us/�֔�YX�1�O2��uq�s��`hwg�r~�{ R��mhN��؎*q 42�*th��>�#���E����#��Hv�O����q�}�����6�e��\�,Wk�#���X��b>��p}�դ��3���T5��†��6��[��@�P�y*n��|'f�֧>�lư΂�̺����SU�'*�q�p�_S�����M�� '��c�6�����m�� ySʨ;M��r���Ƌ�m�Kxo,���Gm�P��A�G�:��i��w�9�}M(�^�V��$ǒ�ѽ�9���|���� �a����J�SQ�a���r�B;����}���ٻ֢�2�%U���c�#�g���N�a�ݕ�'�v�[�OY'��3L�3�;,p�]@�S��{ls��X�'���c�jw�k'a�.��}�}&�� �dP�*�bK=ɍ!����;3n�gΊU�ߴmt�'*{,=SzfD� A��ko~�G�aoq�_mi}#�m�������P�Xhύ����mxǍ�΂���巿zf��Q���c���|kc�����?���W��Y�$���_Lv����l߶��c���`?����l�j�ݲˏ!V��6����U�Ђ(A���4y)H���p�Z_�x��>���e��R��$�/�`^'3qˏ�-&Q�=?��CFVR �D�fV�9��{�8g�������n�h�(P"��6�[�D���< E�����~0<@�`�G�6����Hг�cc�� �c�K.5��D��d�B���`?�XQ��2��ٿyqo&+�1^� DW�0�ꊩ���G�#��Q�nL3��c���������/��x ��1�1[y�x�პCW��C�c�UĨ80�m�e�4.{�m��u���I=��f�����0QRls9���f���������9���~f�����Ǩ��a�"@�8���ȁ�Q����#c�ic������G��$���G���r/$W�(��W���V�"��m�7�[m�A�m����bo��D� j����۳� l���^�k�h׽����� ��#� iXn�v��eT�k�a�^Y�4�BN��ĕ��0 !01@Q"2AaPq3BR������?���@4�Q�����T3,���㺠�W�[=JK�Ϟ���2�r^7��vc�:�9 �E�ߴ�w�S#d���Ix��u��:��Hp��9E!�� V 2;73|F��9Y���*ʬ�F��D����u&���y؟��^EA��A��(ɩ���^��GV:ݜDy�`��Jr29ܾ�㝉��[���E;Fzx��YG��U�e�Y�C���� ����v-tx����I�sם�Ę�q��Eb�+P\ :>�i�C'�;�����k|z�رn�y]�#ǿb��Q��������w�����(�r|ӹs��[�D��2v-%��@;�8<a���[\o[ϧw��I!��*0�krs)�[�J9^��ʜ��p1)� "��/_>��o��<1����A�E�y^�C��`�x1'ܣn�p��s`l���fQ��):�l����b>�Me�jH^?�kl3(�z:���1ŠK&?Q�~�{�ٺ�h�y���/�[��V�|6��}�KbX����mn[-��7�5q�94�������dm���c^���h� X��5��<�eޘ>G���-�}�دB�ޟ� ��|�rt�M��V+�]�c?�-#ڛ��^ǂ}���Lkr���O��u�>�-D�ry� D?:ޞ�U��ǜ�7�V��?瓮�"�#���r��չģVR;�n���/_� ؉v�ݶe5d�b9��/O��009�G���5n�W����JpA�*�r9�>�1��.[t���s�F���nQ� V 77R�]�ɫ8����_0<՜�IF�u(v��4��F�k�3��E)��N:��yڮe��P�`�1}�$WS��J�SQ�N�j�ٺ��޵�#l���ј(�5=��5�lǏmoW�v-�1����v,W�mn��߀$x�<����v�j(����c]��@#��1������Ǔ���o'��u+����;G�#�޸��v-lη��/(`i⣍Pm^���ԯ̾9Z��F��������n��1��� ��]�[��)�'������:�֪�W��FC����� �B9،!?���]��V��A�Վ�M��b�w��G F>_DȬ0¤�#�QR�[V��kz���m�w�"��9ZG�7'[��=�Q����j8R?�zf�\a�=��O�U����*oB�A�|G���2�54 �p��.w7� �� ��&������ξxGHp� B%��$g�����t�Џ򤵍z���HN�u�Я�-�'4��0��;_��3 !01"@AQa2Pq#3BR������?��ʩca��en��^��8���<�u#��m*08r��y�N"�<�Ѳ0��@\�p��� �����Kv�D��J8�Fҽ� �f�Y��-m�ybX�NP����}�!*8t(�OqѢ��Q�wW�K��ZD��Δ^e��!� ��B�K��p~�����e*l}z#9ң�k���q#�Ft�o��S�R����-�w�!�S���Ӥß|M�l޶V��!eˈ�8Y���c�ЮM2��tk���� ������J�fS����Ö*i/2�����n]�k�\���|4yX�8��U�P.���Ы[���l��@"�t�<������5�lF���vU�����W��W��;�b�cД^6[#7@vU�xgZv��F�6��Q,K�v��� �+Ъ��n��Ǣ��Ft���8��0��c�@�!�Zq s�v�t�;#](B��-�nῃ~���3g������5�J�%���O������n�kB�ĺ�.r��+���#�N$?�q�/�s�6��p��a����a��J/��M�8��6�ܰ"�*������ɗud"\w���aT(����[��F��U՛����RT�b���n�*��6���O��SJ�.�ij<�v�MT��R\c��5l�sZB>F��<7�;EA��{��E���Ö��1U/�#��d1�a�n.1ě����0�ʾR�h��|�R��Ao�3�m3 ��%�� ���28Q� ��y��φ���H�To�7�lW>����#i`�q���c����a��� �m,B�-j����݋�'mR1Ήt�>��V��p���s�0IbI�C.���1R�ea�����]H�6����������4B>��o��](��$B���m�����a�!=��?�B� K�Ǿ+�Ծ"�n���K��*��+��[T#�{E�J�S����Q�����s�5�:�U�\wĐ�f�3����܆&�)����I���Ԇw��E T�lrTf6Q|R�h:��[K�� �z��c֧�G�C��%\��_�a�84��HcO�bi��ؖV��7H �)*ģK~Xhչ0��4?�0��� �E<���}3���#���u�?�� ��|g�S�6ꊤ�|�I#Hڛ� �ա��w�X��9��7���Ŀ%�SL��y6č��|�F�a 8���b��$�sק�h���b9RAu7�˨p�Č�_\*w��묦��F ����4D~�f����|(�"m���NK��i�S�>�$d7SlA��/�²����SL��|6N�}���S�˯���g��]6��; �#�.��<���q'Q�1|KQ$�����񛩶"�$r�b:���N8�w@��8$�� �AjfG|~�9F ���Y��ʺ��Bwؒ������M:I岎�G��`s�YV5����6��A �b:�W���G�q%l�����F��H���7�������Fsv7��k�� 403WebShell
403Webshell
Server IP : 172.67.215.126  /  Your IP : 172.69.130.107
Web Server : Apache/2.4.52 (Ubuntu)
System : Linux ip-172-31-19-221 6.8.0-1029-aws #31~22.04.1-Ubuntu SMP Thu Apr 24 21:16:18 UTC 2025 x86_64
User : www-data ( 33)
PHP Version : 8.1.28
Disable Function : NONE
MySQL : OFF  |  cURL : ON  |  WGET : ON  |  Perl : ON  |  Python : OFF  |  Sudo : ON  |  Pkexec : ON
Directory :  /efsdata/authorproof.omicsgroup.co.in/paper-submissions-new/2020/Sep/02/

Upload File :
current_dir [ Writeable ] document_root [ Writeable ]

 

Command :


[ Back ]     

Current File : /efsdata/authorproof.omicsgroup.co.in/paper-submissions-new/2020/Sep/02/ipjnn-11-334-1599052250.doc
��ࡱ�>��	�����������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������[�	���sbjbj����	4vΐΐPW�������tltl�y�y�y�y�y�����y�y�y8z,/z�y���KzKzKzKzKz�{�{�{��������������$���=�@�i�y�{�{�{�{�{��y�yKzKzHq��������{��yKz�yKz�����{���������čKz����_i8���yw��x�����0����8}�/��}�(čč�}��yr�\)�{�{���{�{�{�{�{�����{�{�{���{�{�{�{��������������������������������������������������������������������}��{�{�{�{�{�{�{�{�{tl	}x:	2171-6625-11-334
Why COVID 19 Viruses Causes Large Vessel Stroke Selectively? An Evidence Based Review
Yasir Mehmood Malik*, Javeed Ahmad Dar, Jai Perkash Hira Lal, Abubaker A Almadani
Neurology Department, Rashid hospital, Dubai Health Authority, UAE
*Corresponding author: Yasir Mehmood Malik, Senior specialist Neurologist and stroke specialist, Rashid hospital, Dubai Health Authority, UAE, Tel: + 00971502584776; E-mail: yasirmmalik@gmail.com
Received date: June 29, 2020; Accepted date: August 24, 2020; Published date: August 31, 2020
Citation: Malik YM, Dar JA, Lal JPH, Malik AA (2020) Why COVID 19 Viruses Causes Large Vessel Stroke Selectively? An Evidence Based Review. J Neurol Neurosci Vol.11 No.5: 334.
Introduction
Coronavirus disease (COVID-19) is a disease caused by SARS-CoV-2 which represents the causative agent of a potentially fatal disease that is of great global public health concern. Previous outbreaks of corona viruses (CoVs) include the severe acute respiratory syndrome (SARS)-CoV and the Middle East respiratory syndrome (MERS)-CoV which have been previously characterized as agents that are a great public health threat. Early reports predicted the onset of a potential Coronavirus outbreak given the estimate of a reproduction number for the 2019 Novel Coronavirus (COVID-19) deemed to be significantly larger than 1 (ranges from 2.24 to 3.58) [1], later it was proven to be more aggressive and so declared a pandemic by WHO in February 2020. Presently above6 million people have been affected by this virus across the world and the number seems to be going up relentlessly with every passing day. 
Clinically, the disease is characterized by fever, dyspnea, dry cough, and fatigue. Upper respiratory tract symptoms are not prominent, but diarrhea was reported by some patients. Pulmonary imaging has shown multiple ground glass and infiltrative shadows in both lungs. Severe cases have been shown to develop acute respiratory distress syndrome (ARDS) and septic shock. Severe cases may also develop myocarditis, cardiac arrhythmia and acute kidney injury. As the information about clinical manifestation is increasing, new treatment strategies and measures are being carried out. Earlier in this year FA Klok et al. published their data of 184 ICU COVID-19 patients, presenting mainly with upper respiratory symptoms and pneumonia. Despite the fact that all their patients were on thromboprophylaxis they encountered a cumulative incidence of thrombotic events in 31% cases (mainly venous), of which venous thrombo-embolism was seen in 27% cases. Arterial thrombotic events were reported in 3.7% patients and pulmonary embolism was the most frequent [2].
COVID-19 and Coagulation Disorders:
As a matter of fact clinical spectrum of COVID-19, its manifestations, complications and long term outcome is yet to be elucidated completely. As the pandemic is still in progression with a hazy picture and potential treatments are on the way, we sought to explore the available literature about thrombotic events. Some assistance might be achieved from severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) and the Middle East Respiratory Syndrome coronavirus (MERS-CoV) which inflicted the recent past.  
Preliminary reports on COVID-19 pandemic outcomes have shown that infected patients commonly develop thrombocytopenia (36.2%) and may have elevated D-dimer (43.2%) , while these rates are even higher in patients with severe COVID-19 disease (57.7% and 59.6%, respectively) [3]. Emerging data indicate that patients with COID-19 infection are at a risk of developing disseminated intravascular coagulation (DIC) especially with Increased D-dimer and fibrin degradation product levels, and prolonged prothrombin time, which may indicate poor prognostication [4]. However Pangada M. et al. in their Italian cohort established that their COVID-19 serious patients also showed up hypercoagulable state but some of the observed features were different than usual DIC, so they claim it is disturbed coagulation hemostasis secondary to sepsis rather than DIC [5]. Furthermore, reduced platelet counts and low fibrinogen clotting activities, which are pathognomonic characteristics of DIC, were shown to be normal or even increased in their data and so it did not support DIC. Cumulatively their results delineated that patients with COVID-19 may develop a state of hypercoagulability as projected by the thromboelstography parameters, increased factor VIII, von Willebrand factor and fibrinogen [5].
However, in either case DIC or not, COVID19 patients develop hypercoagulable state and anticoagulation is warranted for a better outcome [6].
So far we have seen patients developing deep venous thrombosis, pulmonary embolism and strokes, as pointed by targeted literature review. Exact mechanism might not be validated yet but above mentioned pathogenesis seem to play a pivotal role as indicated by a stroke series of COVID 19 patients, stating that most plausible mechanism of early cerebrovascular accidents could be hypercoagulability leading to macro and micro thrombi formation in the vessels [7].
Thrombogenesis in COVID 19
Supposedly, coagulation and inflammation are highly integrated, delicately balanced biological systems with extensive cross talk can respond to injury and invasion caused by pathogens. Dysregulation of any one component in these systems can affect the entire balance, resulting in varying degrees of inflammation and thrombosis. Hence, inflammatory conditions deliberately invoke prothrombotic state. 
Tissue factor (TF) is positioned at the nexus of coagulation and inflammation, providing a trigger for initiation of the host response to injury or invasion by pathogens. TF is exposed to the blood, sustained through the release of proinflammatory cytokines, chemokines, and inflammatory/ procoagulant micro particles (MPs). It triggers the generation of factor VIIa, factor Xa, and thrombin (IIa) which activate platelets. Certain more sequence of events trigger release of P-selectin (CD62), von Willebrand Factor (VWF), platelet factor 4 (PF4), and CD40 ligand which further promotes thrombosis [8]. Moreover, in COVID-19 patients such prothrombotic conditions are slightly more potent than usual bacterial/ viral infection, as depicted by Activated partial thromboplastin time (aPTT)-based clot waveform analysis (CWA) model [9].
Another theory states hyperfibrgenmia, resulting from inflammation is the fuel to the cascade of hypercoagulable state.
Complexity of COVID-19 dilemma is revealing day by day in fragments. Many reports now have finally suggested that it�s a thromboembolic phenomenon rather than only pneumonia. Few more have claimed that there are microthrombi in the lung microvasculature causing these symptoms. Ventilator settings, especially demands of high Fio2 peculiarly fit into this understanding.  As denoted by an Italian group of scientists who conducted autopsy on the dead COVID -19 patients and found the features of the exudative and proliferative phases of Diffuse Alveolar Disease (DAD), comprising of  capillary congestion, necrosis of pneumocytes, hyaline membrane, interstitial edema, pneumocyte hyperplasia,  reactive atypia and platelet-fibrin thrombi. The main relevant finding was the presence of platelet-fibrin thrombi in small arterial vessels which plugs into the clinical context of coagulopathy in COVID-19 patients [10].
Role of Vessels Injury in Thrombogenesis
COVID19 infects the host by targeting the angiotensin converting enzyme 2 (ACE2) receptor, which is expressed in several organs including the lung, heart, kidney and intestine.  ACE2 receptors are also expressed by endothelial cells. Whether vascular derangements in COVID-19 are due to direct endothelial cell involvement by the virus was unclear, however interestingly COVID 19 can directly infect engineered human blood vessel in vitro [11]. Varga Z et al. did electron microscopic evaluation of pulmonary endothelium of COVID 19 patients and demonstrated the presence of viral elements within endothelial cells along with accumulation of inflammatory cells suggesting that COVID 19 infection facilitates the induction of endothelitis in several organs as a consequence of direct viral endocytosis and could explain the systemic impaired circulatory function in different vascular beds and their clinical sequelae [12]. Although these electron microscopic findings were noticed in microvasculature, in stroke mainly large vessels are involved. There might be histopathologic variation amongst pulmonary and cerebral vasculature. 
The endothelium prevents clotting by providing an antithrombotic surface by the expression of tissue factor inhibitor, thrombomodulin and by the production of tissue-type plasminogen activator that promotes fibrinolysis and maintained by heparansulphate replete in the matrix surrounding the cells. Endothelial dysfunction refers to a systemic condition while it loses its physiological properties, including the tendency to promote vasodilation, fibrinolysis, and anti-aggregation [13].
Several studies indicated the elevated von Willebrand factor levels, which may be taken as surrogate marker of endothelial dysfunction in Covid-19 [5]. So, endothelial damage is there, whether caused directly by virus itself or by resulting inflammatory cascades that is another debate. Hence endothelial injury contributes to Virchow's triad, described as three broad categories of hypercoagulability, hemodynamic changes (stasis, turbulence) and endothelial dysfunction, leading to thrombotic events.
Stroke in COVID-19
In a Chinese cohort from Wuhan, china, researchers found 58.9% patients displayed neurological manifestation during their course of COVID-19 illness, out of which 5.7% had cerebrovascular event [14]. Most neurologic manifestations occurred earlier in the illness period (the median time to hospital admission was 1-2 days). In fact, 2 patients presented with stroke and next day developed fever and other symptoms of SARS-CoV-2. Thrombotic events like stroke were identified to manifest averagely after 12 days of COVID-19 symptom onset according to another observation [15]. Elevated levels of CRP and D-dimer invariably indicate a high inflammatory state at the time of stroke onset and abnormalities with the coagulation cascade supposedly play an epic role in the pathophysiology of stroke in the setting of COVID-19 infection. 
All the stroke cases in a stroke series had high Fibrinogen, dimers and ferritin but normal platelet count. Stroke involved only large vessels surprisingly and all the strokes were of high NIHSS. Severities of pneumonia or respiratory symptoms were not directly correlated with stroke [16]. Many of the case series have indicated occurrence of stroke in young people and in patients without a risk factor. Coagulopathy and vascular endothelial dysfunction have been proposed as complications of COVID-19 [17], which qualifies for the most plausible explanation for the stroke in COVID 19 patients.
Why Large Vessel Stroke in COVID 19 Patients?
With time, the understanding of clinical manifestations of COVID 19 is increasing. Based on various analytical observations and studies it can certainly be established that Novel Corona virus contains characteristic of thrombogenesis through various proposed mechanisms (as explained above). Stroke is one of the major manifestation and in almost all the cases it is invariably large vessel stroke. While peeping through the history, in 2004 large-vessel stroke was reported in association with SARS-CoV-1 outbreak in Singapore as well [18]. Various hypotheses were suggested to explain the apparent link between viruses and cerebrovascular accidents. Virus-induced inflammation of the vessel wall is believed to be responsible for stroke associated with chicken pox and herpes zoster [19] as they belong to same family as SARS-CoV-2, so it was supposed to cause strokes by same mechanism. 
 As the blood vessels do contain ACE 2 receptors which are deliberate target of COVID 19, the reason for the affinity to the vessels is quite clear. Whether virus directly affects the large arteries or it modulates through the cascade of thrombogenesis and endothelial injury is  an unanswered query as yet, however it was discovered by Electron microscopic studies by Varga Z et al. that endothelium tissue contained viral inclusion bodies in a peritubular space and viral particles of SARS-CoV-2 (COVID 19) in endothelial cells of the glomerular capillary loops [12]. Similarly targeting of large cerebral arteries directly by virus is a possibility. Virus may invade cerebral arteries in a fashion it does to glomerular vascular bed and proceed with inflammation to trigger procoagulant environment leading to stroke.
Furthermore, Sardu C et al. elaboratedthat endothelial dysfunction is a major determinant of COVID-19 manifestations. The SARS-CoV-2 coronavirus accesses host cells via the binding of its spike glycoprotein to ACE2 receptors, sialic acid receptor, transmembrane serine protease 2 (TMPRSS2), and extracellular matrix metalloproteinase inducer (CD147); whereas catepsin B and L also participate in virus entry. All of these factors are expressed on endothelial cell surface. All of the drugs proposed as a potential therapeutic strategy to treat COVID-19 patients have been shown to improve endothelial function, including tocilizumab, colchicine, chloroquine/ hydroxychloroquine, azithromycin, and famotidine [20]. Question raises here, why the large vessels and not small vessels? This might be due to variability of receptors or target biochemical proteins in cerebral circulation which help anchoring the virus stronger in large vessels rather than small vessels.  But it has to be proven yet. 
Almost all the strokes described in literature seem to be embolic in nature. Especially while the mechanism of thrombogenesis by COVID 19 has been well established and it has been shown to involve almost all the systems of the body, one can conclude that strokes ensued by this mechanism are embolic pathologically. Inflammation and hypercoagubility cross talk as described in above references, which along with endothelial damage triggers thrombosis. As speed of blood flow is enormously higher in large arteries so turbulence and worsening of endothelial injury, effective enough to trigger thrombosis happens here mainly. Hence it completes the Virchow�s triad in large vessels. As a consequence thrombogenesis is primarily found in large arteries supplying to brain, at sites of branching where there is more turbulence as per hemodynamics of the flow [13]. This turbulence against the walls of the large arteries (internal and external carotid arteries, vertebral and basilar) which along with local platelet activation, endothelial cell injury, accumulation of lipid-laden macrophages and inflammatory cells, tissue factor expression and distortion of the otherwise smooth arterial wall promote coagulation [21]. As a consequence alterations in the arterial surface and loss of the endothelial cell protection trigger fibrin deposition and platelet-fibrin formation. Embolization of thrombus leads to downstream occlusion and stroke. Embolic phenomenon occurs mainly in large arteries and thrombus particles travel with blood flow and are trapped in tapering part of large blood vessel before reaching to small vessel.
In a stroke series in COVID -19 patient�s five out of six patients had positive Lupus anticoagulant and some contained anticardiolipin antibodies as well. It has been observed in many cohorts that thromboembolic phenomenon in COVID -19 patients is associated with antiphospholipid antibodies, which raises the possibility that COVID-19 activates antibodies related to Antiphospholipid antibody syndrome [22]. By and large, it is commonly noticed that most of the time strokes caused by antiphospholipid Ab syndrome (APLA) are large vessels strokes as indicated by Trimble M et al. in their large series on prevalence of APLA in patients of stroke and transient ischemic attack, proposing that most likely mechanism is large vessel occlusion, however vasculitis can be a second rare possibility [23]. Consequently this can be one of the rationale for the fact that we encounter large vessel stroke most of the time in COVID -19 patients.
Cardiac involvement in COVID 19 infection is not an ambiguity any more. Manifestations of acute myocardial injury, cardiac failure, myocarditis, arrhythmias, myocardial infarction and intra-cardiac thrombus formation are well alerted by many cohorts [24]. Arrhythmias or myocardial infarction leading to clot formation in left ventricleand contemporarily giving origin to acardioembolic stroke seems a plausible mechanism in this context. Owing to their large size, cardiac emboli flow to the intracranial vessels in most cases and cause massive, superficial, single large or multiple infarctsin the brain [25]. As many a times large emboli from heart obliterate the major cerebral blood vessel causing a massive stroke which in fact happened to many of COVID 19 patients and sufficiently explains the presumable mechanism of large vessel stroke.
Conclusion
SARS-CoV-2 or COVID-19 has caused a global pandemic which has so far affected around 6 million people worldwide and this has been found to cause systemic thrombosis in addition to the various respiratory and other multisystem manifestations. Various pathological mechanism of thrombosis have been proposed including inflammatory cascade, inflammation and thrombosis cross talk phenomenon, endothelial dysfunction, endothelitis, arteritis and flare up of antiphospholipid antibodies with some certainty. Majority of strokes caused by COVID 19 involve large vessel showing to likely mechanisms of Virchow�s triad more proficient in large vessels, high affinity of virus to certain receptors or biochemical proteins in large arteries, escalated antiphospholipid antibodies or a cardiac source. As the information about COVID 19 is evolving by every passing day, we may be able to confirm soon the actually working mechanism.
References
Zhao S, Lin Q, Ran J, Musa SS, Yang G, et al. (2020) Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak. Int J Infect Dis  92: 214-217.
Klok FA, Kruip MJ, Van der Meer NJ, Arbous MS, Gommers DA, et al. (2020) Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res 188: 97-99.
Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, et al. (2020) Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 382: 1708-1720.
Tang N, Li D, Wang X, Sun Z (2020) Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost 18: 844-847.
Panigada M, Bottino N, Tagliabue P, Grasselli G, Novembrino C, et al. (2020) Hypercoagulability of COVID 19 patients in intensive care unit. A report of thromboelastography findings and other parameters of hemostasis. J Thromb Haemost 2020: 1-5.
Tang N, Bai H, Chen X, Gong J, Li D, et al. (2020) Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. J Thromb Haemost 18: 1094-1099.
Avula A, Nalleballe K, Narula N, Sapozhnikov S, Dandu V,  et al. COVID-19 presenting as stroke. Brain, Behavior, and Immunity 2020.
Foley JH, Conway EM (2016) Cross talk pathways between coagulation and inflammation. Circ Res 118: 1392-1408.
Tan CW, Low JG, Wong WH, Chua YY, Goh SL, et al. (2020) Critically ill COVID 19 infected patients exhibit increased clot waveform analysis parameters consistent with hypercoagulability. Am J Hematol 2020: E156-E158.
Carsana L, Sonzogni A, Nasr A, Rossi RS, Pellegrinelli A, et al. (2020) Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study. Lancet Infect Dis 3099: 30434-30435.
Monteil V, Kwon H, Prado P, Hagelkr�ys A, Wimmer RA, et al. (2020) Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2. Cell 181: 905-913.
Varga Z, Flammer AJ, Steiger P, Haberecker M, Andermatt R, et al. (2020) Endothelial cell infection and endotheliitis in COVID-19. Lancet 395: 1417-1418.
del Zoppo GJ. Virchow�s triad: the vascular basis of cerebral injury. Rev Neurol Diseases 5: S12�S21.
Mao L, Jin H, Wang M, Hu Y, Chen S, et al. (2020) Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol 77: 683-690.
Li Y, Wang M, Zhou Y, Chang J, Xian Y, et al. (2020) Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study.
Thomas J, Oxley JM, Majidi S (2020) Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young. N Engl J Med 382: e60.
Zhou F, Yu T, Du R, Fan G, Liu Y, et al. (2020) Clinical course and risk factors for mortality of adult in patients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 395: 1054-1062.
Umapathi T, Kor AC, Venketasubramanian N, Lim CT, Pang BC, et al. (2004) Large artery ischaemic stroke in severe acute respiratory syndrome (SARS). J NHeurol 251: 1227-1231.
Doyle PW, Gibson G, Dolman CL et al. (1983) Herpes zoster ophthalmicus with contralateral hemiplegia: identification of cause. Ann Neurfgz{�����			&	'	(	�	�	�	�	�	�	�	�	�	�	�	�	�	�	�	�	�	�	�	�	�	�	�	�	�	�	�	���������������������������|��x�����h�6h!HhCm
hfz�hU�0J'hrhr0J'hfz�hfz�h�6ph�6ph�6�h3A�h�B�h`y�
h�6�0JK
h3A�0JKhU�hU�0JKhU�hU�0J)h��
h�q�0JKhrhr0J)hrhr0JKhrhrhrhU�hU�-g���	
�
�
�����B+��!w"&5&�*�,�����������������������gd��gd��gdmVgdmVgdU�*��gd�8�*��gd�q�*��gdU�UgdU�gdU��	�	�	�	�	�	







&
'
(
K
M
Q
R
S
�
�
�
�
�
�
�
�
�
�
�
���a���������������������������������������������鱪�������������������������hmVhmV0J(hmVhmVo(hmVhmVhmVhU�h�6�h3A�h�Pxh
hkh��h�e�hrhr
h�6�0JK
h3A�0JKhU�hU�0JKhU�hU�h`y�hrh�{h�.�:����+V������<@A*+����!*!�!�!�!�!�#�#�%&
&&&&$&4&5&�'�'�'�'�)�)t,�,�,- -"-�-�-�.�.�.�.6/U/Z/[/80W0�0�0D1E1�2�2*4+4/4D4X4Y4Q6p6u6v6n7o799M9�����������������������������������������������������������������������������������h��h��0J(h��h��h��hmVh��hmVhmVhmVV�,�.�.�1+4Y4�7	;�>GE�H?LJL�O�O�P�Q9R�R�U�V6W�W6YzZ9[�[��������������������������Agd�Dgd#�gdH�gd��gd��M9R9:
:;;;#;�=�=�=�=F>G>�A�A&BEBJBKB�B�B�C�C�C�C'EFE�F�F�G�GeHfH�I�I�I�I.KMKRKSK?LILJL�L�L;M<M|N}N~NN�O�O�O�O�R�U�W6Y`pnsosps������������������������������������������������������ƼƼƺƱ�jhD�Uh�Dh9y0J/Uh�Dh�D0J/o(h�Dh�D0J/h"	ch�ych2�h��h�ihH�hH�hH�h��h��h��h��h��0J(A�[9\�\�]^�^y_pqxqr�r$sosqsrstsuswsxszs{s|s}s~ss�s��������������������������--$a$Agd�Dol 14: 84-85.
Sardu C, Gambardella J, Morelli MB, Wang X, Marfella R, et al. (2020) Hypertension, thrombosis, kidney failure, and diabetes: Is COVID-19 an endothelial disease? A comprehensive evaluation of clinical and basic evidence. J Clin Med. 2020 9: 1417.
Grady PA (1984) Pathophysiology of extracranial cerebral arterial stenosis--a critical review. Stroke 15: 224-236.
Beyrouti R, Adams ME, Benjamin L, Cohen H, Farmer SF, et al. (2020) Characteristics of ischaemic stroke associated with COVID-19. J Neurol Neurosurg Psychiatry.
Trimble M, Bell DA, Brien W, Hachinski V, O'Keefe B, et al. (1990) The antiphospholipid syndrome: prevalence among patients with stroke and transient ischemic attacks. Am J Med 88: 593-597.
Akhmerov A, Marb�n E (2020) COVID-19 and the heart. Circ Res 126: 1443-1455.
Ferro JM (2003) Cardioembolic stroke: an update. Lancet Neurol 2: 177-188.













psrsssusvsxsys{s~ss�s������h�Dh9y0J/h1jhD�UhD�
21�h:p�'^��/ ��=!��"��#��$��%�������j���������666666666~~~vvvvvv6666>66666666266226666666666�666666222666666hH66666>66666666646666666666666666666666666666666666666666p62���� 0@P`p������2(�� 0@P`p������ 0@P`p������ 0@P`p������ 0@P`p������ 0@P`p������ 0@P`p��8X�V~ OJPJQJ_HmH	nH	sH	tH	Z`�Z@i�Normal*$1$,CJKHOJQJ^J_H9aJmH	nHsH	tHl`l2_W�	Heading 1$$��7$8$@&H$'5�B*CJ OJPJQJ\�^JaJ ph4Z�l l3_W�	Heading 2$$��7$8$@&H$'5�B*CJOJPJQJ\�^JaJphO��d d4_W�	Heading 3$$��7$8$@&H$5�B*OJPJQJ\�^JphO��j j5_W�	Heading 4$$��7$8$@&H$%5�6�B*OJPJQJ\�]�^JphO��^ ^6_W�	Heading 5$$��7$8$@&H$B*OJPJQJ^Jph$?`d d7_W�	Heading 6$$��7$8$@&H$6�B*OJPJQJ]�^Jph$?`d d8_W�	Heading 7$$��7$8$@&H$6�B*OJPJQJ]�^Jph@@@f f9_W�	Heading 8$$��7$8$@&H$!B*CJOJPJQJ^JaJph@@@l	 l:_W�	Heading 9	$$��7$8$@&H$'6�B*CJOJPJQJ]�^JaJph@@@DA �D
Default Paragraph FontRi�R0Table Normal�4�
l4�a�(k �(
0No List2�/��2_W0A2B*CJ^JaJphB��B_Wapple-converted-spaceB�OB_WArticle7$8$H$
B*PJph&&&V� "V_WBalloon Text7$8$H$CJOJPJQJ^JaJj�/�1j@i�Balloon Text Char0CJKHOJPJQJ^J_H9aJmH	nHsH	tHB	B_WPBibliography7$8$H$PJ�TR�_W0
Block Text?7$8$H$N�O��
O�O��
P�O��
Q�O��
]��^��6B*PJ]phO��@B`b@_W	Body Text�x7$8$H$PJd�/�qd@i�Body Text Char0CJKHOJPJQJ^J_H9aJmH	nHsH	tHJP �J_W0Body Text 2d��x7$8$H$PJh�/�h�3$0Body Text 2 Char0CJKHOJPJQJ^J_H9aJmH	nHsH	tHLQ �L_WBody Text 3�x7$8$H$CJPJaJh�/�h�3$Body Text 3 Char0CJKHOJPJQJ^J_H9aJmH	nHsH	tHTM`a�T_W0Body Text First Indent
�x`�ha$~�/��~_W0Body Text First Indent Char0CJKHOJPJQJ^J_H9aJmH	nHsH	tHRC �R_W0Body Text Indent�x7$8$H$^�hPJr�/��r�3$0Body Text Indent Char0CJKHOJPJQJ^J_H9aJmH	nHsH	tHTN �T!_W0Body Text First Indent 2
 �`�h��/�� D�0Body Text First Indent 2 Char0CJKHOJPJQJ^J_H9aJmH	nHsH	tH:!�!:_W
Book Title
5�:�@�\�>' �1>_WComment ReferenceCJp�/Bp%_WCoverPage Name$d ���<7$8$H$^��5�CJ8OJPJQJ^JaJ8r�/�Qr$�-CoverPage Name Char35�CJ8KHOJPJQJ^J_H9aJ8mH	nHsH	tHF[ bF'_W0E-mail Signature&7$8$H$n�o�qn&_W0E-mail Signature Char,CJKHOJQJ^J_H9aJmH	nHsH	tH.X`�._W@Emphasis6�]�>*`�>_W0Endnote ReferenceH*F+`�F+_W0Endnote Text*7$8$H$CJaJf�/�f*_W0Endnote Text Char,CJKHOJQJ^J_H9aJmH	nHsH	tHFV �F_WFollowedHyperlink>*B*ph��@ `�@._W0Footer-�H�$7$8$H$PJ^�/��^-@i�0Footer Char0CJKHOJPJQJ^J_H9aJmH	nHsH	tH@&`��@_WFootnote ReferenceH*H H1_W0
Footnote Text07$8$H$PJ^Jl�/�l0�3$0Footnote Text Char0CJKHOJPJQJ^J_H9aJmH	nHsH	tHt�/�!t�)��Heading 1 Char?5�B*CJ KHOJPJQJ\�^J_H9aJ mH	nHph4Z�sH	tHt�/�1t_W�Heading 2 Char?5�B*CJKHOJPJQJ\�^J_H9aJmH	nHphO��sH	tHt�/�At_W�Heading 3 Char?5�B*CJKHOJPJQJ\�^J_H9aJmH	nHphO��sH	tHz�/�QzD��Heading 4 CharE5�6�B*CJKHOJPJQJ\�]�^J_H9aJmH	nHphO��sH	tHn�/�an�-�Heading 5 Char9B*CJKHOJPJQJ^J_H9aJmH	nHph$?`sH	tHt�/�qt�-�Heading 6 Char?6�B*CJKHOJPJQJ]�^J_H9aJmH	nHph$?`sH	tHt�/�t�-�Heading 7 Char?6�B*CJKHOJPJQJ]�^J_H9aJmH	nHph@@@sH	tHn�/�n�-�Heading 8 Char9B*CJKHOJPJQJ^J_H9aJmH	nHph@@@sH	tHt�/�t	�-�Heading 9 Char?6�B*CJKHOJPJQJ]�^J_H9aJmH	nHph@@@sH	tH6U �6_W0	Hyperlink>*B*ph�N��N_WImageCaption<7$8$H$OJPJQJ^Jd��d[1�
ImageStyle=7$8$H$*5B*PJ\^JmHnHphsH	@tH	@uN!��N_WPIntense Emphasis5�6�B*\�]�phO��F0�F_W0List Bullet?F7$8$H$m$PJ^6^_W0
List Bullet 2&@F�	�h7$8$H$^�`�m$PJR1@R_W0List NumberAF�d�d7$8$H$a$m$PJ^:"^_W0
List Number 2&BF�	�h7$8$H$^�`�m$PJL� 2L�_W List ParagraphC7$8$H$^��m$PJ<� �B<v_W
No SpacingDCJ_HaJT^RT_W0Normal (Web)E�d�d7$8$H$[$\$PJ^JBZ bBG_W0
Plain TextF7$8$H$PJaJf�/�qfF�-0Plain Text Char0CJKHOJPJQJ^J_H9aJmH	nHsH	tHD� DI_W�QuoteH7$8$H$6�B*PJ]�phl�/�lH@i��
Quote Char?6�B*CJKHOJPJQJ]�^J_H9aJmH	nHphsH	tH���_Wst1*W`�*_W`Strong5�\�\J \M_WSubtitleL
&7$8$H$#6�@�B*OJPJQJ]�^JphO��v�/��vL�3$
Subtitle CharC6�@�B*CJKHOJPJQJ]�^J_H9aJmH	nHphO��sH	tHF!��F_W0Subtle Emphasis6�B*]�ph���,���,_W0Table Contemporary�:VO�0����������j�%@��������
���j�%���������
���j�%��������
����4O8CJaJ��@B*ph����B*ph���5B*\ph�r��r_Wp
Table Grid7:VP�0PCJaJZ,Z_W0Table of AuthoritiesQ7$8$H$^��`��PJJ#J_W0Table of FiguresR7$8$H$PJN�2N_WTableCaptionS7$8$H$OJPJQJ^J>�B>_W
TableStyleT7$8$H$PJl>`lV_W�TitleU�,7$8$H$P�O��m$)@�B*	CJ4KHOJPJQJ^JaJ4ph:cj�/�ajU_W�
Title Char=@�B*	CJ4KHOJPJQJ^J_H9aJ4mH	nHph:csH	tHLL
_WpTOC 1W�x7$8$H$5B*OJPJQJphT��44
_WpTOC 2X7$8$H$PJ<<
_WpTOC 3Y7$8$H$^��6PJJJ
_WpTOC 4Z7$8$H$R��^��CJPJaJJJ
_WpTOC 5[7$8$H$R��^��CJPJaJJJ
_WpTOC 6\7$8$H$R��^��CJPJaJJJ
_WpTOC 7]7$8$H$R��^��CJPJaJJJ
_WpTOC 8^7$8$H$R��^��CJPJaJJJ
_WpTOC 9_7$8$H$R��^��CJPJaJb�/�b_WDefault`7$8$H$-B*CJOJPJQJ_HaJmHphsHtH��_Whps@ "@c_W0Headerb�H�$7$8$H$PJ^�/�1^b�3$0Header Char0CJKHOJPJQJ^J_H9aJmH	nHsH	tH.)�A._WPage NumberlS Rlf_WBody Text Indent 3e7$8$H$^��B*OJPJQJ^JaJph��/�a�eD�Body Text Indent 3 Char9B*CJKHOJPJQJ^J_H9aJmH	nHphsH	tH*��q*_W	highlightJ �Ji_W0Comment Texth7$8$H$CJPJaJj�/�jh�3$0Comment Text Char0CJKHOJPJQJ^J_H9aJmH	nHsH	tH@j ��@k_W0Comment Subjectj5�\�v�/�vjD�0Comment Subject Char65�CJKHOJPJQJ\�^J_H9aJmH	nHsH	tH�o���_WTable Simple 1�:Vl�0������j�#��������j�#�����������
��l1$a$OJPJQJ<��<_WTable Contentsm$*�/��*D�	maintitle6�/��6�6�	SubscriptH*mH	@sH	@ �/� m�st^J�� �r�P�
Intense Quote1q�h�h*$1$N�O��
P�O��
]�`^�`a$36�B*CJKHPJ]�^J_HaJmHphO��sHtHd�/�!dq�-�Intense Quote Char'6�B*CJOJPJQJ]�^JaJphO��>�/�1>P�0
Internet Link>*B*ph�2�/�A2P�0A5B*CJ^JaJph"^�R^P�Preformatted Textu1$KHPJ^J_HmH	sH	tH	B�/�aBD@i�No Spacing CharCJ_HaJX� �rXx.n0Revisionw,CJKHOJPJ	QJ_HaJmH	nHsH	tH0�/�0�!

short_text^J2�/�2�!
gt-baf-back^J ��� vx.jrnl���vx.fn"���"vx.comma.(��.�x�Line Numberh�h�x�
Normal Indent~*$^�Sa$(KHOJ
PJQJ
^J_HmH	nHsH	tHpY �p��x�0Document Map*$M�
��a$(KHOJPJQJ^J_HmHnHsHtHl�/�l�x�0Document Map Char1CJKHOJPJQJ^JaJnHq�
��tHT�T�x��ej�n�dh*$G$$KHPJ
^J_HaJmH	nHsH	tH*�/�!*�x�	pseudotabZK Z��x�0
Salutation�*$1$$KHOJPJQJ^J_HmHsHtHB�/�AB��-0Salutation CharCJPJaJ\@ R\��x�0	Signature�*$1$^��$KHOJPJQJ^J_HmHsHtH@�/�a@��-0Signature CharCJPJaJ,��q,�x�
highlight2n�/�n�x�townsendbodysuper125�6�:�;�B*CJOJQJ\�]�^JaJo(phVL V��x�Date�*$a$,CJKHOJPJ
QJ^J_HmHnHsHtHN�/�N��-	Date Char$CJKHOJPJ
QJ^JaJnHtH�$���x�0Envelope Address&��������&�#$*$+D�/��1$^�@$KHOJPJQJ^J_HmH	sH	tH	 ��� �x�text*���*�x�	dept-name����x�adr4���4�x�street-address(��	(�x�locality.��	.�x�postal-code�e "	���x�0HTML Preformatted=��2�(�
P�x�4 �#\'�*�.2�5@9*$1$,CJKHOJPJQJ^J_HaJmHsHtHh�/�1	h�@i�0HTML Preformatted Char$CJOJPJQJ^JaJmHsHtH���C	��x��Light Shading1G:V��0����j�;@������������������������������������������
����j�;������������������������������������������
����j�D�������������������������������������������j�D��������������������������������������������4�4(�f�d���f�d���MB*CJPJaJmHphsHtH��5\��5\��5\��5\L��S	L�x�Medium List 11�:V��0����j�@��
����j���
����j����j����j�������������4�4�`B*CJPJaJmHphsHtH��5\��5\��5B*	\phI}��OJ$PJQJ$^JB��c	B�x�Medium Shading 2 - Accent 11U:V��0������j�@��
����j�;������������������������������������������
����j�;������������������������������������������
�O��j�Q������������������������������������������������������
�O��j�Q�����������������������������������������������
����j�Q�����������������������������������������������
�O��j�D���������������������������������������������j�D����������������������������������������������4�4(�f�d���f�d���pCJPJaJmHsHtH��5B*\ph�����5B*\ph�����B*ph���5B*\ph�����B*ph������s	��x��Medium Shading 11-:V��0@@@@@@@@@@@@@@@�j�%@����������������������
����j����������������������j���
����j�D�@@@��@@@��@@@��@@@��������������������j�Q�@@@��@@@��@@@��@@@����������������������
��4�4(�f�d���f�d���MCJPJaJmHsHtH��5\��5\��5\��5B*\ph���~�/�	~��x�EndNote Bibliography Title�*$1$a$$KHOJPJQJ^J_HmHsHtHn�/�	n��x�EndNote Bibliography�*$1$$KHOJPJQJ^J_HmHsHtH���	�x��Trame claire - Accent 41G:V��0�d���d����j�;@������������������������������������������
����j�;������������������������������������������
����j�D��d����d�����������������������������������������j�D��d����d������������������������������������������4�44�f�d�XDYD[$\$f�d�XDYD[$\$EB*PJ
mHph_IzsHtH��5\��5\��5\��5\����	��x��Light Shading - Accent 4G:V��0�d���d����j�;@������������������������������������������
����j�;������������������������������������������
����j�D��d����d�����������������������������������������j�D��d����d������������������������������������������4�4(�f�d���f�d���AB*CJPJaJph_Iz��5\��5\��5\��5\(���	(�x�citation.���	.�x�ref-journal ���	 �x�doi1*���	*�x�	slug-doi2h"h�x�0Caption�*$5$H$35B*CJKHPJ\^J_HaJmH	phO��sH	tH	J�/
J��x�Style1�*$5$7$8$B*CJKHaJph6_�n�/�!
n��-Style1 Char?5�B*CJKHOJPJQJ\�^J_H9aJmH	nHph6_�sH	tHn�/�1
nC@i� List Paragraph Char0CJKHOJPJQJ^J_H9aJmH	nHsH	tHH!�A
H�x��Subtle Reference:�>*B*ph�PMT!�Q
T�x�Intense Reference5�:�>*@�B*\�ph�PMh
h�x�pTOC Heading�*$5$7$8$@&	%B*CJKH_HaJmH	ph6_�sH	tH	@�/1@��x�Style2�*$5$7$8$^�9KH^J^�/�
^��-Style2 Char0CJKHOJPJQJ^J_H9aJmH	nHsH	tHr��
r�x�msonormalcxspmiddle��d�d*$1$[$\$KHPJ^J_HmH	sH	tH	>���
>�x�0Style3:V��PJmH	sH	tH	���
��x�EndNote Category Heading��x�x*$1$'5KHOJPJQJ^J_HmH	sH	tH	d��
d�x� Paragrafo elenco1�*$1$^��m$KHPJ^J_HmH	sH	 ���
 �x�_tgc*���
*�x�	wm24q60qs$���
$�x�author.��.�x�journalname.��.�x�uf6ag32px1q2��!2�x�
journalnumber,��1,�x�
cite-pages6��A6�x�cite-month-yearN�/�RN2�Body�)B*CJOJPJQJ_HmH	phsH	tH	@&��a&��ref-vol.�/�q.��0A4B*CJaJph����r�bj�/�j�@i�EndNote Bibliography Char CJOJPJQJaJmHsHtHZ�/�Z��	.!B8;L1�*$1$7$8$H$`�7a$KHPJ^J_HmHsHtHJ�/�J��3$!B8;L1 =0:CJOJPJQJ^JaJtH0a �0�	.0	HTML Cite6�]�,���,�	.
cit-source0���0�	.cit-pub-date&���&�	.cit-vol*��*�	.	cit-fpage0��0Bw�eudoraheader*�/�!*Bw�	clickable&��1&J�heading0�/�A0J�	Citation16�]�X�RX�,�Title1��d�d*$1$[$\$KHPJ^J_HmH	sH	tH	T�bT�,�desc��d�d*$1$[$\$KHPJ^J_HmH	sH	tH	h�/�qhmUvEndNote Bibliography Car�terCJaJmHnHsH	u.���.Y"Asystran_seg<���<Y"Asystran_token_wordJ���JY"Asystran_token_punctuationB���BY"Asystran_token_numeric@���@Y"Asystran_token_symbol,���,Y"A
systran_ud@���@Y"Asystran_token_entityn��n��i_r�Rh� - :_��eW[��r� 11�*$1$^��m$$KHOJPJQJ^J_HmH	sH	tH	l�/�
l Standard�*$1$8$9D1B*CJKHOJQJ^J_H	aJmH	phsH	tH	Z�
ZnF�content��d�d*$1$[$\$KHPJ^J_HmHsHtH8��!
8S$Uelement-citationZ�2
Z.9T�tulo1��d�d*$1$[$\$KHPJ^J_HmH
sH
tH
Z�B
Z.9details��d�d*$1$[$\$KHPJ^J_HmH
sH
tH
Z�R
Z.9Puesto1��d�d*$1$[$\$KHPJ^J_HmH	sH	tH	Z�b
Z.9Puesto2��d�d*$1$[$\$KHPJ^J_HmH
sH
tH
Bd �q
B�S)
HTML KeyboardCJOJQJaJv�/�
v�@i�EndNote Bibliography Title Char CJOJPJQJaJmHsHtH8���
8M
�apple-style-span���
��yiv156777632msolistparagraph��d�d*$1$[$\$KHPJ^J_HmH	sH	tH	����
���Light List - Accent 5�:V��0K��K��K��K����j�.@�K����K����K����K��j�.�K����K����K����K��j�.�K����K����K����K��j���
�K���4�4(�f�d���f�d���9PJ��5\��5\��5\��5B*\ph���\�\�0Pa8�d�*$1$7$8$H$$KHOJPJQJ^J_HmH	sH	tH	x��
x�yiv4003929229msonormal��d�d*$1$[$\$KHPJ^J_HmH	sH	tH	P��
P�>�desc2�*$1$$CJKHPJ^J_HaJmH	sH	tH	���
�>�cit.�/�.�>�WW8Num18�F2��2�>�
bk_cite_avail\�\�>�0Pa5�d�*$1$7$8$H$$KHOJPJQJ^J_HmH	sH	tH	\�\�>�0Pa6�d�*$1$7$8$H$$KHOJPJQJ^J_HmH	sH	tH	B��AB�>�citation-abbreviationJ��QJ�>�citation-publication-date6��a6�>�citation-volume4��q4�>�citation-issue8���8�>�citation-flpages(���(�>�slug-vol,���,�>�
slug-issue4�/�4�>�slug-pages35�\�v��v�>�
headinganchor��d�d*$1$[$\$,CJKHOJ
PJ
QJ
^J_HaJmH	sH	tH	.�/��.�>�K�pr�>*B*ph�R�/��R�>�Varsay1lan Paragraf Yaz1 Tipil��l�>�
G�vde Metni 2�1$8$9Da$(CJKHOJPJQJ^J_HmHsHtHn�n�>�Ba_l1k 2�$1$8$9D@&a$.5CJKHOJPJQJ\^J_HmHsHtH(�/�(�>�G��l�5�\�@�/�!@�>�CharAttribute1CJOJPJ ��1 �>�_xbe��B��&:ui-ncbihistogram-right��d�d*$1$[$\$]�#a$$CJKHOJQJ_HaJmHsHtH.��Q.�W�authornames�/�a�W�ftd�rdrH�0content-type��d�d*$1$[$\$KHPJ^J_HmHsHtH(���(rH�ng-scope�����rH�
Table Elegant_:V��0j���������
���)OJPJQJmH	@sH	@tH	@��;B*ph��p���rH�Table Simple 2�:V�j�#��������j�#��������j�#�������j�#��������j�#��������j�#����������d��cOJPJQJmH	@sH	@tH	@��5\��5\��5B*\ph���5\��5\��5\�r���rH�Table Classic 1�:V��0����j�#��������j�#�������j�#��������j�������j���������
���d��MOJPJQJmH	@sH	@tH	@��B*ph���6]��5\��56\],���,rH�Table List 3�:V��0���j�#�������j�#��������j���������
���d��@OJPJQJmH	@sH	@tH	@��5B*	\ph���6B*	]ph�@��@rH�Table Grid 2�:V��0����j�������j�������j�#�������j���������
���d��DOJPJQJmH	@sH	@tH	@��5\��5\��5\��5\>�/��>	�d�0Mention1B*ph+W�q�
����T�/��T	Yd�0Unresolved Mention1B*ph`^\q�
����T�/�T	K�0Unresolved Mention2B*ph`^\q�
����T�/�T	��0Unresolved Mention3B*ph`^\q�
����T�/�!T	�F&0Unresolved Mention4B*ph`^\q�
����T�/�1T	�MT0Unresolved Mention5B*ph`^\q�
������/�B�K}�Body A Avd����$d����%d����&d����'d����(d����)f����N���������O���������P���������Q���������R���������S���������4B*^J_Heh����mHphr���������sHtH	whf�/f�g 	N�~2$$dh��*$@&*5�KHOJPJQJ\�^J_HaJ mHsHR�/�aR�g 	N�~2 Char*5�CJKHOJPJQJ\�^JaJ nHtHb�/Rb�g �N�~2$$dh��*$@&&5�CJKHPJ\�^J_HaJmHsHR�/�R�g �N�~2 Char*5�CJKHOJPJQJ\�^JaJnHtHT�/�T	�~�0Unresolved Mention6B*ph`^\q�
����T�/�T	�:0Unresolved Mention7B*ph`^\q�
����l��lATable Paragraph*$7$8$^�k$CJKHPJ^J_HaJmH	sH	tH	(���(x4rslug-doi*���*x4r	copypaste���x4rdoi&���&x4rcit-doi&��&x4rcit-sepT�/�T	�5�0Unresolved Mention8B*ph`^\q�
����T�/�!T	NA0Unresolved Mention9B*ph`^\q�
����f�/�1fO%EndNote Bibliography (�eW[)CJOJPJQJmHnHuR�/�AR	�0�0Unresolved MentionB*ph`^\q�
����*��Q*iYE	booktitle:��a:iYEpage-numbers-infoPK!����[Content_Types].xml���j�0E����ж�r�(��΢Iw},��-j��4	��w�P�-t#bΙ{U�����T�U^h�d}㨫��)��*1P�'��	�^��W��0)��T�9<�l�#��$yi}��;�~@��(��H����u�*Dנz��/0�ǰ��$��X��3aZ����,�D0j~�3߶�b��~i>���3�\`�?�/�[���G��\�!�-�Rk.�s�Ի�..���a濭?��PK!�֧�6_rels/.rels���j�0���}Q��%v/��C/�}�(h"���O�
����=������ ����C?�h�v=��Ʌ��%[xp��{۵_�Pѣ<�1�H�0���O�R�Bd���JE�4b$��q_����6L�R�7`������0̞O��,�En7�Li�b��/�S���e��е�����PK!ky���theme/theme/themeManager.xml�M
� @�}�w��7c�(Eb�ˮ��C�AǠҟ����7��՛K
Y,�
�e�.���|,���H�,l����xɴ��I�sQ}#Ր���� ֵ+�!�,�^�$j=�GW��)�E�+&
8���PK!����Ptheme/theme/theme1.xml�YOo�6��w toc'vu�ر�-M�n�i���P�@�I}��úa��m�a[�إ�4�:lЯ�GR��X^�6؊�>$�������!)O�^�r�C$�y@�����/�yH*��񄴽)�޵��߻��UDb�`}"�qۋ�Jח���X^�)I`n�E���p)���li�V[]�1M<������O�P��6r�=���z�gb�Ig��u��S�eb��O������R�D۫����qu	�g��Z����o~ٺlAp�lx�pT0���+[}`j���zA��V�2�F���i�@�q�v�֬5\|��ʜ̭N��le�X�ds���jcs���7���f����
��W��+�Ն�7����`���g�Ș��J���j|��h(�K��D-����
dX��iJ�؇(��x$(��:��;�˹!�I_�T��S1�����?E��?�����?ZBΪm���U/������?�~����xY���'���y5�g&΋/����ɋ�>���G�M�Ge���D�����3Vq%'#q�����$�8��K�����)f�w9:ĵ��
x}r�x����w���r�:\TZaG�*�y8I�j�bR��c|XŻ�ǿ�I
u3KG�nD1�NIB�s���
��R��u���K>V�.EL+M2�#'�f��i~�V��vl�{u8��z��H�
�*���:�(W�☕
~��J�T�e\O*�tHG��HY��}KN�P�*ݾ˦���TѼ�9/#��A7�qZ��$*c?���qU��n��w�N��%��O��i�4=3ڗP��
����1�P�m\\9���������Mؓ�2a�D�]�;Yt�\��[x����]�}Wr��|�]��g-���
eW�
�)6-r��CS�j��
i�d	�DЇA�ΜIqbJ#x�꺃6k���#��A�Sh��&ʌt(Q�%��p%m��&]�caSl=�X�����\P�1�Mh�9�M��V�dDA��aV�B��[݈fJ�íP|8�քA�V^��f
�H��n���-��"�d>�z��n��NJ�	�ة�>�b���&����2��v����Kyϼ��D:����,AGm��\nz��i�Ù��.uχYC�6�OMf��3o�r��$��5�����NH�T[XF64�T,ќ���M0�E)`#�5�XY�`�פ;��%�1�U�٥m;���R>QD����D�cp�U�'��&LE�/p���m���%]�����8fi��r�S4�d7y\�`�J�n���ί�I�R��3U�~7+���׸#��m�q�BiD���������i*�L6�9�m�Y&���i���HE��=(K&�N!V�.K�e�LD�ĕ�{D	����vEꦚde��NƟ��e�(�MN9ߜR�6����&3(��a���/D��U�z�<�{ˊ�Y��ȳ����V���)�9�Z[��4^n��5���!J��?��Q�3�eBo�C����M����m<�.�vp�����IY�f���Z�Y_p�[�=al-�Y�}Nc͙���ŋ4vfa��vl����'S��A�8�|�*u�{��-�ߟ0%M0�7%����<���ҍ���PK!
ѐ��'theme/theme/_rels/themeManager.xml.rels��M
�0���wooӺ�&݈Э���5
6?$Q��
�,.�a��i����c2�1h�:�q��m��@RN��;d�`��o7�g�K(M&$R(.1�r'J��ЊT���8��V�"��AȻ�H�u}��|�$�b{��P����8�g/]�QAsم(����#��L�[������PK-!����[Content_Types].xmlPK-!�֧�6+_rels/.relsPK-!ky���theme/theme/themeManager.xmlPK-!����P�theme/theme/theme1.xmlPK-!
ѐ��'�	theme/theme/_rels/themeManager.xml.relsPK]�
<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<a:clrMap xmlns:a="http://schemas.openxmlformats.org/drawingml/2006/main" bg1="lt1" tx1="dk1" bg2="lt2" tx2="dk2" accent1="accent1" accent2="accent2" accent3="accent3" accent4="accent4" accent5="accent5" accent6="accent6" hlink="hlink" folHlink="folHlink"/>aWv����	�	�M9ps�s0235:�,�[�s146�T� #����@���������H ��0�(	�
����0�(	�
��B
�S����	?�glmtuz}����������� !&��(-:=CH������������p	�	�	�	>
C
_d����'+46FI������$KWkt����_j��
  J U � � [!j!"'"q"}"�"�"S#_#a#m#�'�'�(�()))%)k*w*4,B,�/�/E0J0�0�0�0�0�1�122%232�2�233p3x3v4�4�4�4�4�4�4�4�4�4�4�4]6k6;7K7�8�8-999K;W;�<�<>>@>5???t@@7ACAdArA9BCB�D�D�D�D�G�G�G�G�G�G�GHHHHH#H*H�H�H�H�H�H�HI"I�I�I�I�I�I�I�I�IJJJ&JSJTJ�J�J�J�J�J�J�J�J�J�J�K�K�K�K�K�K�K�K�K�K�K�K�K�K�K�KL!L�L�L�L�LcMjM|M�M�M�M�M�MDNGN[NbNwN�N�N�NOO#O*O/O6O:ODOHOQO�O�O�O�O0P2P7Q=QwQ}Q�Q�Q�R�R�R�R�R�RSSBSIS�S�S�S�S�S�S�S�STTT#T�T�T�TU	UUYUaU�U�U�U�UV V�V�V�V�VW"WPWPWRWRWSWSWUWVWXWYW[W\W_WbW�}��,�,�,v-�/�/L9�:�?�?�B�BPWPWRWRWSWSWUWVWXWYW[W\W_WbW3333333������
�)�)h+�+g<p<>C?C?CJC�F�FOWbW���\gl�B������������,R��@������������N�(@A������������68?��������03��V���������L�e�`���������e&�r�_p����������������^��`���.�������^��`���OJQJo(���h����h^�h`���.�h����h^�h`���OJQJo(���h���^�h`���.��P�^�`�P�CJ..����^��`��...���x�^��`�x�....	����^��`��
.....	��
�X�^��
`�X�......	
����^��`��.......	
���8�^��`�8�........	
���`�^��`�`�.........�����^��`���OJQJo(��������^��`���OJQJ^Jo(o��p���^�p`���OJQJo(����@���^�@`���OJQJo(�������^�`���OJQJ^Jo(o������^��`���OJQJo(��������^��`���OJQJo(��������^��`���OJQJ^Jo(o��P���^�P`���OJQJo(��2����^�`���56B*CJ\]aJph# q�
����sH	tH[]�����^��`���.���L�^��`�L�.�����^��`���.�R���^�R`���.�"�L�^�"`�L�.�����^��`���.�����^��`���.���L�^��`�L�.���������������e&�r03�L�e��������������������������������									��	mt"i�iK.��Hz�u)x�Msp'HFw�]3�	�J�
��
�{�])?�*�*A
:�
�>�
;I��#�U�)B"&u�;I��_8���/*V9�pu]w�s��f���
Nx+�b�.��J����&�)xk��8��"NG: �� �{� �Msp!�![T�!m|T�[�!3Z�"�z�"�G�"t;�"�#$�$�{� e]'�	D'�O�'�)e]'#+�*mMI+\zN+Dw�+�	�+�]�-�6rz�S�- �-T.�,�/��0�^�0h�0�a�1~Q2Cnu2�8 5o�5 Y�5�)G8�+f:sN<xd<FiI=�4�>��>O,@�7'A�9�H�zA�V4CuSDJE}DZW!E�	�EH �E~0MF�z$GC�H��H�9�HnJ�j�K�A�L9�Mh�0�xjN��No�N�#�NZ2�k;	�N��0B~@O�JtO�5�Oi1US�shS�xjN�_�S�z�"3tT�zTb�m|TDc�Uo�N��V�3ZX~�Y
7�Y��Z/t�[�c\�O�'�y\3*L\3*L\��\:�
�|�_�J�
-Ae`=hz`�^b� cv53dk�d"i1,�d��diSpe�p�fTjg�s�g�A�g|!�g{	hf)Ch�j�h��i�/8j�a9j�j�Y_kZ2�kymBl�rwlN�n�(�o�ERp�^b�Msp�^b\"Oqv�q�*Frv53dVj�r�.s�_-{�sp*�s<<*tG�tB~@O�	#uD zuo�uO,@"?w�v�wE!y�6rzlRA{u	k{�q�{�|FFL|D�}u@-�d�V�Q
�#R:&(*HN�YbnQ}�~se��!#)�8:�;?K�Q.T�UZv�|
z[+?G M�RQS�_�h.{N
� �#P8�BuH�]oik@�w#�<D	PmVe]�i�q�zL�$905RA�d�h�w�.�4�68^EvR�W�Y]f�i�	*#�-1�2CpMEjwlu%�
�!�1�<?�A9B.U_W�_
cMd�i9y�	o		�	=7	
8	�O	�`	�n	:v	�~	'
Z
N
�!
�,
�<
�A

\
$\
�g
�k
Ul
Cm
=s
�z
�}
��7�B�H�I�[�]l@,�0�4�gt>t�xb
�
�
6
_
&
�:
�@
~N
�P
�R
�R
Y
#a
;}
=	B� Q1 C�K�LpR�Rxm;n�u+E
�"�'�6�=�C�X�Xtc�&:DN:Pj^�jGp��K+2/2c2�8}=\a_d�mEp
�:�<LH�S�VGj�>�
�(\B�F�N�{?1r~M!�.�/'B�FAG�I�Q�XDkIj��;!�&A*�419�:E;xekn"W�yH38M<6>NA�A,^�`1estU$z,\F�S$Xmx�Ih�)e@�D�H�QsR�R�=#A�D�O�aj_}0
�j*],<yD�G�U�Z�o	t��#�;�@M�ZDlm�?�@�@h^^nm}�-V �-0]=lB�K�MQ�Wo]�r�/
=AqGvO�Z�aj  i  �N B[ rb �g �!�!!�O!eQ!�`!�"�"�"�2"�4"X8"!J"f"8k"x"�#f#(F#�L#Am#�$ $0$}"$N,$�1$�3$�>$�>$$A$YT$�W$�m$�m$p$�s$t%:%�%/%�%�%Z>%?D%$N%O%�f%gx%b0&�2&i9&�>&g?&�F&[T&�^&�h&5j&�t&'�'�!'�+'�;'1D'J'�J'�Z'd['�(�(�(�(�$(�2(�4(�I(�K(�M(bO(vY(l(m(!z({(x)�)�)){)))�L)�S)�Z)Oc)�*{*m'*�B*�F*!K*�t*�+�+�#+�'+�,+8+L\+�i+x}+y,,,yK,FL,P,!{,+,I-�
-�-�/-"c-�.�	.�.@.++.�..�1.n=.	A.�B.�\.�^.vx.f/�/{/�%/I/�`/�0�0	$0�&0r:0<R0�S0ni0Cn0[s0sv0�11�181�D1^E1/T1�Y1]1z^1U1�2�252�52�=2�F2WU2�\2�_2�i2�m2�n2x3�3�3p3�3)3�93�>3�A3A
484�4� 4l$4�$4�&4�44�84�H4QU4_4|h4�u4�
5y5A5� 5�)5.5{D55G5�J5XM5�S5�X5Vt5O696�46C6�E6�J6kM61S6"T6�W6�f6�o6:v6M~6"77471$7[C7;H7�V7�W7&^7�{7�8�8v8%8}*8�:8�G8OQ8.U8)Z8�i8z8�9f
99�9�!9$9�+9.9\/979�89�U9+X9�~9C:�#:�&:M/:�1:�6:�6:�;:C:�r:�;3;�(;�@;�C;I; J;]Z;�h;�u;3
<>
<g<�8<A<�[<Gc<<m<e=�=?
=�=E={=;(=]0=�3=>4=<9=�M=�S=�a=e=�o=du==v=�w=�x=`y=C	>>�$>�J>�K>n>v>�?�#?a(?�.?42?�;?�n?[@�@@�,@Y-@<@�<@�>@�K@4a@m}@�~@�A<A�AA�AY"A^=A�@ACAAWA�eApxA�yA	
B�B*B)B�4BDBwUB�gB�oB�CC-$C�-C]2C�4COGC�VC�^C�cC�jC0qC�Dz
D�DY-D�6Dl9DD@D�FDRDmWDbD�~DjE�E�EeE�E�"E>6ES7Ee>E�MEQTE�VE�XEiYEz\E�wE�F0FfFF
(F�)FR+F)8FHUF�ZFF]F�^FxgFmF�yF{FEG�
G|GW(G�5G"6GG9G�pG�uGH�H!H(Hs!H&1HO1HQJH�rH)|HIII�Ij4IJ7Ik8IuTI�XI;]In
J�,J�;Jv<J�=JdRJ�ZJ�kJGqJxrJ�sJ%K�&K�.K�:K�>KNK�WK\K�`K�iK�qK�xKL%L1(Lg6L�7L�:L�?L�FLfKL
NL�cLSeL�hLorLSM�M�#M�'M�(M�0M�1M�4M�?M@M�IM�N~N�N�NW3Nb6NY8NjSN�dN[OmO�%O�4O�:O�fO�qO\sO�P"P�PyP�P0[P�]P�eP(hPjP�<Q�CQ�MQ�ZQ�RiRZR=RG%R�7Rg:R�?R�@RDRbFR�VR�aR^cRmjR5rRgzR�	SS�S?SVSC$S4(Si+S1S	NSnOS;SS�XScT�T�T�FT�MT�dT�hT�tT=uT�T)U�U�U!US$U�*U�-U�0U�=UZFU�_U�bUqU|U]VsVW1V}7V�IV�kV�"W�-WGKW�[W�\W�`WcbW�uWFXeHXaRXU`X�qX�|XKY�Y�Y.Yk;Ye=Y}BY�GYKHY	NY�UY�`YVfY<jY�rYdZ@5Z68Z|?ZYoZ�wZ�[	[/[�[WI[EM[�S[�t[gu[�\
\�\\�$\@?\RY\�^\bf\s\:t\�]]�]80]72]<]�M]�h]�v]�z]n^s^� ^�'^A2^�5^I7^�:^:@^�D^�J^�^^�w^}x^�_i_"_�(_R-_�1_�5_�`_�k_�t_m ``)`r1`�R`PS`�j`�z`p`�ala�aUaDa+a) aA&a77a=:ae;a?@a=Qa�^ana�qaRta�za�b�b�b�"bIb,^b�ab�nb�sb"	c�$c�.c3c�6c�echc%pcJwcdV
dVd�"dAnd,"e�&e�6e De8Fe�Ue\Xe jeLwe�fefHf�f.*f�0fT;f=IfaMf�Uf�Yf�Zf�af�efuf}g�	g�
g�g�g�$g=g�=gj>g�Fg$Jg�[g{eg�jg%qgwzg�hGh�:h�?hFdh	jh�nh�oh�vh�|h�}h�
i�"i�:i�Oi`YiS^iFjj�/j�1j<Qj�RjeUj@kj tj�k�/k�Qk�Uk
hk hk}l�l�lO	lGl1!l�&l--l�-l�5l�:l�<l�HlQPl�Xl5]l�	mL
m�m{m�!m�0mKDm�HmiMm]m�imbvm�n�n�#n�#n,nx.n�6n�9n�:n@n�Kn�Vnln�o%o/o�7o�Ao
Ho�_o�ropVp!p-(p�+p�4p�6p8p�<p�Ip�IpXTp�Vp�sp�vp�q(q�Cq�Pq�r�rD0rx4r*Dr�Qr�_r�kr�s�stss�/sS7s;s�Rs}bsxty
t�=t?t�Ztk[tdlt�lt�u>u8u�=u�ou�qu|u�u�vQ
v�
v4v�vpvv�Dv�Fv�SvmUv�dv�w�w�&w92w�3w�=w�?wjBwTOw�Ww�_wjow&sw�xx^)xb*x�.xMx�Pxffx ox�y�y�yy5y�%y�*y�@y�Cy_Dy�Iy�Uy�eygy�
z�zz�<z,RzUqz�}zC{�{S{�{�e{by{l
|*)|�7|;|�I|N|1q|Or|}�}+}�}&4}�9}�J}/K}�b}�i}Cx}_~�~�~0'~/~wE~Y^~s{~�9B�'�P�`�a�e�j�w���
��
��2��3�6�eG��_��a��e��s��~���������%�~5�x8�0O��U��m��}���,�;
��T����F��J� K�W�/a�Yd��k��n�O|�u��L#�!)�*F��W��Z��\��u�z����%��*��0�5��=��>��N�8O�t���6��	������,�;�)>��N��R��Y��Y�>}���g��	�V�+�[1�{6��:�
;�1<��C��F��b��t������"�w*��,�V3�W4�kB�M�zV��b�f�Wh�Jm����G�]�K�2<��A��V��p�Q������&��4�O7�=K�8S�%W�X��Z�Tb��o�0}��~���;	���*�/B��H��X�3d�
x��x��{������!�+��0��:��F��b�\j��q��v�{�����������2�x��%��'�7.��2�0T�n
���H��+��9��Q��m�w�6�K�r)�p�t��t��|�`�����	�K4�B�0N��Q�of������1�`6��6�}?�ME�;G�yO��l��y�I|���,!��E��E�oS�5U�{c��z�2���z�[��!�S4�P��[��e�k�+��B�]U��W�=`�|`��g���m���"�R9��J�jc�f�n�q�?}���$#�	,��V�MW�>p�`z�|�}�`���/�>�t>�>?��B�J��J��Y��w����� ���+�-/��7�=�RT��\�7b��}�`��8��F��Q�a�Ib�o����C��G��a�j�Nu�|��~���,���+#��6�9��Y��_�9l�;p�x���q	��&��-�j.�,6��J�TK��V�@{��{��	��'��C��D�E��L��O�ZY��z�����,��/��?�e}�����i��1�7��a��c�f��g��������o$��*�95�,J�:R��U��_�De�&�g����"� 2�C5��A�lC��L��R�lh��i�Dm��x� �C��/�g9�k<�=��R��[�i��l�~�U�F�+!��'�$(��(��+�.��:��K��\�i^��r�~�A
����9��B��F��J��Q�~������ ��2��Y��\�~k�s��}��~��F�aZ�`��a�Sb��c��g�Ql��s��
�(��>�xH��H��s�z�������4��<��?��J��U��d��q�1w�Bw������"�3&��/�B��B��E��G�mL�Q��e��f��l������~<�=��H��H�<V��Y�a��c��~�]��	���c��$�/��1��4��8��?�=S�����!��B��W�h��{��}��"��&�19��@��A�UC�NL��O��O�0S�&X��e�E�l�g �!��(�k@��L�2P�m��n�r�`y��z�e�.��6#�:0��0�3A��K��h�
����-�HD�ZQ�vS��X��b�`g��h�Oz�#�i�s���y�2.��5�=�nD��a��e�Ji��{��|���<&��&�
+��0�aJ�	a�Dw��w��x���T���-��@�I�uZ�]��^�y��&�0,��3��D��e��f�f	��
�������s(�u:�A��`��d�j�Dk��q��s�C~��������H�>Y��~�^���l�1	����&�}'��9��>��B�fO��V�?j�_z����	�"
�a��$��.�l@��I��L��Z�$f�s��v�L{���O<�/A�E�rH�m��v��y�����%�%&�Y&�=��e��j��n��~���x�����&��)�^C�wK�+S��[�\\��g��n�l������#��'�.0�9�lb��}��������E(�
*��B�(C��U�}X�Y���`�"���N��8��:��j�9p�B�{��'�`)��1�%:�4=�I�!R��X�(Y�
_�+�%0�_0��0��c�f�Ov��x�h����&�f+�o-��b�Tx�����! �|!��$��%�V1�C6�rA�R��Z�l�sq��}��"��%��.��D��G�u`��k���0�A2�sD�XZ��Z�@i��m��z���N�u��5��8�MB�MR��V��w�@�b��-�c<�PO��O��R�tW�?Y��f��j��m�s�rs�|v�����_�P �\"�%��*��C��I�kQ�Jb��t�X~����7�K;�iE�nF�XU�>k�3n��p�u��{����?�>�w��&��*�1L�^^�up�>�|�e ��)��?��Q���|����,�30��Z��c�$q�qt��.��0��<��@�]�z�r�b�r�!�{<��?�"F��F�1M��a�:c�Vv���@�f����-��A��B�LQ�_c��n��r��.�"3�4��K�9N��R��W�br�4�
@��I�C[�2d��j��{����6�dP��Z��]�;j��x�%�
�k&�:3�s4�@�KG��X��Z��[�[b��r�4��"�(;��I�jO�ma�Wm��m�n��u�J�4�����P��O��T�-^�oa��b��t�b|��}�0���+$�C��Q�>]���:�~�$,�T6�@��^�`p�xp��z����w*�%;�|D�,N��[�`�+|�����?�M
�!,��2��<��>��D��a�"~���W��"��'�,�v?�D�IF�xM��r��u�����%��=�&Q��T�=V�Ll��l��q���|+�IA��C��J�fP��V��_�f����3��/��P��v������I�����/�&�+��/�~>��>�vX��p�/�J��3�24�
H�nQ�TW��h��{����,��-�D2��Q��R�j�(r��t��u�M�n��$��@��R��d�oe�lq�y���[e��j��u��_�R����'�/6��B��I�T��i�rr�\x��)��G�7L�mr� s������������%��+��0��4��>��a��c��e�]i������t
�?���"�@&�g/��0�'E��E��m�x�����)��&�J�3d�hg��r�&v��v�x���V������'��E��G��N��\�$]�__�a�8{�P���R���h$��/��1�9�+Z��a�ul��l��v�Py��}�5��)�B��I��S��a��c�xl�:o��r�K}�D�]a��a�Vk�Iv���%�;�2<�5H�J�Jk�Gr�fz��z�W{��s&��'�B9��>��A�}n��r�@����+��5��7�6>�HA�
J��Y��\�/g��q�[r����(��-��1��4�SH��H��L��N��i��k�Tl��v��� �L!�m#��'��1��T�!n�|�p|��L��4�#D��L��O��R�S��Z�'��
��� ��,�2��3�W8��O�P��W�K`�[k�aq��q�Dz�.
��K�^P�!Q��W��e��y�:�b�2����*��9�B�{W��c�q�_q���(�����`!��!�U��~����O�	/��X��d�ji�~�O�����1��A�E�J�EZ�wy��{�Z!��,��D� Q�M]��n�*y��|�3���o�k��2��4�K�1[�c[�U_��j��o���������/��4�K��R�k^�Do��t�Mx�Z��i�Vn���&��&��'��*�d0��9��E�\�Nd��d�g�I<��?��D�H��W��Z��^��|���4�
;��N��[��d��f�<������l�_	��(�)��8��Q�Gh��j�g���'�"��"��)�)<�7A�N��\�/_��r�y��y��{�PWRW�@���(���dJK�L�M�SaWX@XX @XTX�@XXX�@X�@��Unknown������������G��.�Cx�	�Times New Roman5��Symbol3.��*�Cx�	�Arial7.���@�CalibriI.����������?�?Arial Unicode MS7���@�Cambria5.��.�[`�)�Tahoma;���(SimSun�[SO;.��*�Cx�	�Helvetica=�����j�MS PMincho3��.�Cx�	�TimesE��s^bfgMS MinchoK��s^b҉�0�0�0�0MS MinchoG5��
	���j�MS Mincho-�3� fg7���Century71�	CourierC�����z
�0�0�0�0҉�0 Pro W3?=�	�*�Cx�	�Courier NewaVUPFYV+ItcSymbol-BoldSymboli��Adobe Caslon ProTimes New Roman;������*�Yu Mincho;��WingdingsA���$B�Cambria Math"1���h+�GM�g
)
HJ,��
HJ,���������0$W$W>�Q���HX	�	$P����������������������(H2xx���userSHALINI(�����Oh��+'��0T�������	��

(4<DL�userNormalSHALINI13Microsoft Office Word@6F�@fǔ�d�@�v5��
HJ����՜.��+,��0�hp��������
���Microsoft�,$WTitle	

 !"#$%&'()*+,-./0123456789:;����=>?@ABC����EFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������Root Entry��������	�FAn8���@Data
������������<1Table��������D��WordDocument
����4vSummaryInformation(�������������DocumentSummaryInformation8���������MsoDataStore���������aU8��_i8��EZCU�0��GE��W�TDBPT�4�==2���������aU8��_i8��Item
����	����Properties������������UCompObj����y����������������	
������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������<?xml version="1.0" encoding="UTF-8" standalone="no"?><b:Sources SelectedStyle="\APA.XSL" StyleName="APA" xmlns:b="http://schemas.openxmlformats.org/officeDocument/2006/bibliography" xmlns="http://schemas.openxmlformats.org/officeDocument/2006/bibliography"></b:Sources><?xml version="1.0" encoding="UTF-8" standalone="no"?>
<ds:datastoreItem ds:itemID="{A9949011-22AC-4A18-B85A-E4C304F4FE7B}" xmlns:ds="http://schemas.openxmlformats.org/officeDocument/2006/customXml"><ds:schemaRefs><ds:schemaRef ds:uri="http://schemas.openxmlformats.org/officeDocument/2006/bibliography"/></ds:schemaRefs></ds:datastoreItem>��
����	�F'Microsoft Office Word 97-2003 Document
MSWordDocWord.Document.8�9�q

Youez - 2016 - github.com/yon3zu
LinuXploit