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�d�m Kellner MD.1 , Vasana S. Kellner MD.1 , �va Kar�di MD.1 Bal�zs Koll�r MD.1,  Mikl�s Egyed MD., Ph.D.1 



1 Kaposi M�r Teaching Hospital Kaposv�r, Department of Hematology







Key words: metothrexate, psoriasis, rheumatoid arthritis, immunotherapy, hematological toxicity









Corresponding author:
Mikl�s Egyed MD., Ph.D.
 HYPERLINK "mailto:rajnicsp@hotmail.com" dregyedmiklos@yahoo.com
Kaposi M�r Teaching Hospital
H-7400 Kaposv�r, Hungary
Talli�n Gy. str. 20-32.

Abstract

The incidence of autoimmune diseases increasing nowdays. Despite of the development of diagnosis and management of diseases, they remained chronic diseases. The patient�s lifespan expansion requires longterm treatment with harmful agents, such us metothrexate or other immunosupressive drugs.  The metothrexate toxicities are based on the duration and cumulative dosing of drug, and the combination with other drugs. Myelosuppression and consequent pancytopenia is the most frequent hematologic toxicity, which occur mostly later during low dose metothrexate administration. 
We demonstrate three cases of low dose metothrexate toxicity in older patiets with rheumatoid arthritis and psoriasis.  
All patients were treated with low dose metothrexate along more than one year continously. 
Two old patients with RA and another with psoriasis developed pancytopenia causing severe neutropenia, cutaneous bleeding, and bruising and septic condition. They required intravenous antibiotic therapy, corticosteroids and limited transfusion dependence as a result of low dose metothrexate.
We have assessed the possible causes of metothrexate toxicities and found that all patients used non-steroid antiinflammatory drugs because of pain and proton-pump inhibitor to avoid development of peptic ulcer. Two patients recovered, another died in septic condition.
We would like to drawn attention of hematologists, dermatologists and rheumatologists to the harmful effect of low dose methotrexate in this patient population and emphasize the role of rigorous and consequent hematologic testing to avoid these severe late complications. 




























Introduction 

The incidence of autoimmune diseases increased to the end of twenty centuries. Despite of the development of diagnosis and therapy in medicine, autoimmune diseases remained incurable. Only longterm treatment with harmful agents is available for these patients, such us metothrexate or other immunosupressive drugs. 
Metothrexate, a synthetic antifolate was developed in the 1950�s after the discovery that dietary folic acid deficiency resulted in decreased blast cell count in leukemic patients.
This drug has been extensively investigated and used successfully to treat solid tumors as well as hematological malignancies. It has been used, in much lower doses, in autoimmune diseases including rheumatoid arthritis, psoriasis, lupus, sarcoidosis and eczema (1).
By inhibiting several enzymes of the folic acid pathway MTX blocks purine and pyrimidine biosynthesis, leading to impaired DNA replication and cell proliferation. Tissues with high cellular turnover are thus the most sensitive to the cytotoxic impact of metothrexate, which is responsible for its effectiveness as a chemotherapeutic agent, but also for many of its side effects such as mucositis, hair loss and cytopenias.
Myelosuppression and pancytopenia including thrombocytopenia, megaloblastic anaemia, leukopenia are the most frequent hematological toxicity, which occur later during low dose metothrexate traitment. The hematologic toxicity is a serious and potentially life-threatening, still often underestimated complication of low dose MTX therapy. The pancytopenia often causes neutropenic sepsis. Low dose metothrexate therapy can become dangerous, in particular with the elderly, who are at a greater risk for significant myelosuppression.
The prevalence of hematological toxicity is estimated to be 2-4% of all treated cases (2). It may be much higher in the presence of predisposing factors: folic acid deficiency, hypalbuminaemia, renal impairment and interaction with other drugs. 
MTX induced pancytopenia can either occur in the early stage of treatment, possibly as a result of an idiosyncrasic reaction (2). The methotrexate late toxicities are based on the duration and cumulative dosing of drug, and probably the combination with other drugs. 
In this paper, we present three cases with pancytopenia and neutropenic sepsis. The differencial diagnosis, the treatment and possible drug interactions are also discutted. 

Case reports

Patients characteristics

The main characteristics of the patients are listed in Table 1. All patients were treated with low dose MTX in another Hospital and were referred to our department because of pancytopenia. All patients had febrile neutropenia and septic condition. 
The patients and relatives were asked particularly for anamnestic data. All patients were treated along more than one year with low dose MTX because of autoimmune disease. Periferal blood smear of patients were examined and bone marrow aspiration were made to exclude any underlaying hematological malignancy. No bone marrow infiltration nor increased blast ratio were observed. 
The diagnosis of MTX caused pancytopenia was based in all cases on the exclusion of previous conditions. 

Case 1

59-year-old female with a medical history of hypertension, asthma and rheumatoid arthritis had been taking metothrexate for 2 years in a weekly dose of 15 mg. She had been taking theophyllin for her asthma in a daily dose of 300mg and daily 550mg Naproxen for her painful arthritis. She had 38�C fever two times the week before admission, and physical examination revealed oral mycositis with bruises all over her skin. Her vital signs were stable and her laboratory results showed pancytopenia (WBC:2.09 G/l, neuthrophils:1.28 G/l) hemoglobin 63 g/l, hematocrite 20%, platelets 12 G/l), low serum protein level (51g/l), high CRP (184.7 mg/l), with normal renal functions. Peripheral blood smear and bone marrow aspiration analysis ruled out haematological malignancies which underlied the suspicion that MTX induced myelosupression was responsible for our findings. 
We started empirical antibiotic and antimycotic therapy together with Ca-folinate and parenteral corticosteroid. She also recieved red blood cell and platelet infusions. 
After 12 days of therapy her symptoms improved significantly and her hematological parameters developed to almost normal (WBC: 4.28 G/l, neutrophils: 2.79G/l, hemoglobin: 91g/l, hematocrite: 27.3%, platelets 121 G/L).


Case 2

83-year-old female with a medical history of hypertension, ischaemic heart disease and rheumatoid arthritis had been taking metothrexate for 16 months in a weekly dose of 16 mg subcutaneous injection (0.3 ml sc/week). Patient had been taking aspirin for ischaemic heart disease in a daily dose of 100mg and pantoprasol for peptic ulcer profilaxis in a daily dose of 40mg. She had 39.5�C fever before admission, and became confused in her home. Physical examination revealed tachycardia, hypotonia and tachypnoe and urinary bleeding.  Her vital signs were instable and she was admitted in septic condition to our department.  Her laboratory results showed pancytopenia (WBC:1.02 G/l, neuthrophils:0.4 G/l) hemoglobin 83 g/l, hematocrite 27%, platelets 5 G/l), low serum albumin level (32g/l), high procalcitonin level (13 ug/l), with decreased renal functions (Creatinine 189 umol/L, GFR:18 ml/min). Peripheral blood smear and bone marrow aspiration analysis excluded haematological malignancies. MTX induced myelosupression was diagnosed. Empirical combined antibiotics and infusion were introduced with Ca-folinate and parenteral corticosteroid. She also recieved platelet transfusions. Hemoculture was positive, enterococcus fecalis developed. Despite of the accurate therapy, patient died after 2 days because of multiple organ failure. 

Case 3	

78-year-old female with hypertension, diabetes, erosive gastritis and psoriasis had recieved metothrexate 15 mg/week for 19 months when she was admitted to our department with febrile neutropenia. She had been taking pantoprasol for erosive gastritis in a daily dose of 40mg and gliclaside for diabetes mellitus in a daily dose of 60mg . On admission she had oral mucositis, her laboratory results showed severe myelosupression (WBC: 0.12 G/l, neutrophil: 0.02 G/l, hemoglobin 81g/l, hematocrite 22.4%, platelets 23 G/l), low total protein (45 g/l) and albumin (23 g/l) levels, elevated renal function (creatinine 114 umol/l) and high CRP (296.9 mg/l). She was immediately started on a combination of parenteral antibiotics and local antimycotics, recieved corticosteroids, Ca- folinate, red blood cell and platelet transfusions. On the 8th day of her treatment her cell counts started to normalize (WBC: 10.34 G/l, hemoglobin 102 g/l, platelets 44 G/l).




Discussion

Methotrexate is the commonest disease-modifying antiinflammatory drug used in monotherapy or in conbination with other drugs and biological agents the treatment of many autoimmune disorders. MTX, a highly selective competitive inhibitor of the enzyme dihydrofolate reductase. It consequently reduces the production of thymidylate and purine biosynthesis. DNA synthesis eventually halts and cells can no longer replicate (3). 
The folate antagonist MTX also works on the adenosine pathway with important anti-inflammatory effects. Inhibition of transformylase by MTX leads to accumulation of 5-aminoimidazole-4-carboxamide ribonucleotide and ultimately leads to increased levels of adenosine. Adenosine is a potent inhibitor of inflammation and induces vasodilation. This effect of MTX does not seem to be affected by folate supplementation (4). The intracelluar polyglutamination of MTX prolongs its intracellular presence, which contributes to their toxicity (5,6). Adverse side effects can be quickly progressive and fatal. The main side effects include myelosuppression, hepatotoxicity, pneumonitis and renal toxicity.

Hematologic toxicity
The prevalence of haematologic toxicity, including leucopenia, thrombocytopenia, megaloblastic anaemia and pancytopenia, is estimated to be 2-4% (2). The frequency of pancytopenia may increase if other drugs, such as non-steroidal antiimflammatoric durgs (NSAID), proton pump inhibitor (PPI) and antidiabetics are co-administered. The prevalence of pancytopenia may be increased in case of folic acid deficiency, hypoalbuminemia, concomitant infections, advanced age, dehydratation and renal impairment (7). 
Pathogenesis of MTX inducing panctopenia is still unknown.  Pancytopenia may be acute or chronic and thought to be an allergy-like reaction (8). MTX and folates compete cellular uptake, cellular storage as polyglutamates and binding to enzymes, because of their structural similarity. Depleted intracellular folate levels have been documented in peripheral blood lymphocytes of RA patients treated with MTX (9). Delayed drug clearance had been observed in the elderly. This is caused by prolonged enterohepatic circulation, which is responsive to higher risk of pancytopenia. Leukopenia occurs from one to three weeks and marrow recovery is generally observed within approximately 3 weeks (2, 10-13).
 Discontinuation of MTX represents the basis of therapy but the use of G-CSF and methylprednisolone are also beneficial (14). 

Hepatotoxicity
Hepatotoxicity is a common complication of long term treatment with MTX (15,16), especially in the case of obesity, alcoholism, diabetes, non alcoholic steatohepatitis and hepatitis B or C infection (17,18). Elevated aminotransferases levelare the most common laboratory sign of hepatotoxicity. It was observed in MTX-treated rhumatoid arthritis and psoriatic arthritis patients with a frequency varying from 7,5 to 26% (16). The hepatotoxic side effect of the MTX is unclear. Folic acid supplementation is associated with a reduced incidence of aminotransferases elevation in inflammatory disease treated by MTX (19).

Pulmonary toxicity
Pneumonitis is one of the most serious but infrequent side effects of chronically used MTX. Its prevalence seems about 0.9 to 1% (20). It has been thought, that a hypersensitivity reaction to MTX mediated by activated T-cells plays a role in the mechanism of pneumonitis (21). In fact, MTX leads to a cytokines release by type 2 alveolar cells causing an alveolitis by recruitment of inflammatory cells (22). 
MTX can also stimulate lung fibroblasts and epithelial cells to induce recruitment of eosinophils (23). It has been also demonstrated that neutrophiles are implicated in the pathogenesis of lung fibrosis (24). Cough, dyspnoe may occur from few days to more than a year after the begining of MTX therapy  and also several weeks after MTX discontinuation (25). 

Renal toxicity
Renal toxicity occures mostly in higher doses of MTX, especially intravenous administration of this drug. MTX and its metabolites are relatively insoluble in acid urine (26).  An increase in the urine pH results on a greater solubility of the drug and its metabolites. For that reason, it is recommended to monitor renal function time to time in order to control renal side effect especially in case of higher dose administration of MTX. However the serum creatinine may be a misleading measure of renal function in older patients because of an overall reduction in lean muscle mass. Urine alkalinization and leucoverin rescue are the cornerstones of the management of the earlier signs of renal dysfunction (15,27).

Factors that contribute to the toxicity
Advanced age is a significant predictor for MTX toxicity (28). The pharmacokinetic profile in alderly patients, change drug distribution. The decreased lean body mass and end-organ blood flow, and decreased hepatic drug metabolism, or decreased renal drug excretion lead to toxicity. MTX side effect can be increased in renal impairment or reduced renal blood flow, as with NSAIDs use (29). Therefore MTX is contraindicated in any patient with eGFR <30 mL/min (28). 
According to pharmacokinetic studies, about the 50 % of MTX is bounded to serum albumin in the circulation (42�57%), whereas their metabolite (7-hydroxymethotrexate) is extensively (91�93%) bound. Significant interindividual variations in the activity of binding proteins lead to the efficacy and potential toxicity of MTX. The free portion of MTX determines the influx of MTX into cells and its rate of clearance by the kidneys. Hypoalbuminaemia results in increased levels of free MTX because MTX binding to serum albumin is proportional to the amount of albumin, resulting in increased risk of myelotoxicity. Hypoalbuminaemia in RA may be due to increased albumin turnover, presumably caused by high consumption of albumin at sites of inflammation and poor nutritional status. Occult chronic liver disease and advanced age may also be reflected in low serum albumin (29). Poor nutritional status has been associated with increased risk of MTX toxicity.

Prevention and Management of MTX Toxicity
There are some general aspects of MTX administration and post-treatment management. To avoid MTX side effects, it is advised that routine blood count be performed every four to eight weeks (1) and  it is mandatory to determine renal function time-to time. When renal fuction impaired, MTX dose adjustement is necessary. When creatinine clearance (CrCl) is between 30 and 60 ml/min, dose of MTX is reduced by 50% and when CrCl is under 30 ml/min, dose of MTX should be reduced by 75% (30). Folic acid treatment (1 to 3mg/day) after 2-3 days of MTX administration decreases the frequency of toxicities, such as mucositis, hematologic abnormalities and liver enzyme elevations, without seeming to interfere with clinical efficacy (31).
 The most complicated prevention practice is the avoiding drug interactions. Most alderly patient take many drugs which having the potential to displace MTX from serum proteins and/or to reduce MTX clearance. The most known are interaction with trimethoprim and sulfamethoxazole (TMP-SMX) and NSAIDs (30, 32,33).
Alteration of the elimination of MTX was also reported with antibiotics such as aminoglycosides, some penicillins and macrolides (34), mezocilline (35), piperacillin (36), amphotericine B (37) and ciprofloxacin (38). Protone pump inhibitors such as omeprazole (39,40), had same interactions.
Monitoring plasma MTX level is an essentiel part of high dose MTX therapy, but it is not necessary in low dose MTX treatment.
Our three cases demonstrated, that the low dose MTX can cause easily life threating complications. Monitoring for hematologic toxicity should be done every 4 to 8 weeks by primary care physicians but our patients had no blood sampling for 4 months.  All patients had septic condition due to granulocytopenia and despite of adequat treatment one patient died in multiple organ failure in our department. Age is also a determinant of whether patients will survive pancytopenia and its associated complications, such as sepsis, as the age
of our died patient was 83 years whereas the age of those who recovered from severe sepsis was lower.
We would like to draw attention to toxic effect of low dose metothrexate of hematologists dermatologists and rheumatologists and primary care physicians. 

Conclusions
Despite possible side effects of weekly administered low dose MTX used in autoimmune diseases, MTX is very well tolerated and its efficacy is excellent. When monitored correctly, the side effects can be avoide. It is very important that primary care physicians, the hematologists aware of these complications and recommendations, because the majority of these serious complications can be detected on time and even prevented. Patients on MTX therapy should be regularly monitored with renal and liver function and hematology tests to identify myelosuppression and avoid the sequelae of pancytopenia. 
More attention should be paid to patients� nutritional status especially the serum albumin level before commencing MTX. Folic acid supplementation should be considered in all patients taking MTX.
In our experience, MTX-induced pancytopenia is more common than expected and is probably under-reported. We recommend vigilance for this late and potentially fatal complication of MTX therapy.

Conflict of interest
None of the authors have any conflict of interest to disclose.

Authorship
PR collected data, interpreted data and wrote the manuscript, VSK wrote the manuscript, �K collected data, �K performed physical examination and made table, BK wrote manuscript, ME designed case report and wrote the manuscript.


References

1. R. W. Simms, C. K. Kwoh, L. G. Anderson et al.: Guidelines for monitoring drug therapy in rheumatoid arthritis: American College of Rheumatology Ad Hoc Committee on Clinical Guidelines.  Arthritis and Rheumatism, vol. 39, no. 5, pp. 723�731, 1996.
2. S. Gutierrez-Urena, J. F. Molina, C. O. Garcia et al.: Pancytopenia secondary to MTX therapy in rheumatoid arthritis Arthritis and Rheumatism, vol. 39, pp. 272�276, 1996.
3. Kremer J, Galivan J, Streckfuss A, Kamen B, et al:  Methotrexate metabolism analysis in blood and liver of rheumatoid arthritis patients. Association with hepatic folate deficiency and formation of polyglutamates. Arthritis Rheum 1986;29:832�5.
4. S. Bar-Yehuda, M. H. Silverman, W. D. Kerns, A. Ochaion, S. Cohen, and P. Fishman: The anti-inflammatory effect of A3 adenosine receptor agonists: a novel targeted therapy for rheumatoid arthritis. Expert Opinion on Investigational Drugs, vol. 16, no. 10, pp. 1601�1613, 2007.
5. A. Y. N. Lim, K. Gaffney and D. G. I. Scott: Methotrexate-induced pancytopenia: serious and under-reported? Our experience of 25 cases in 5 years Rheumatology 2005;44:1051�1055.
6. L. Brunton, B. Chabner, and B. Knollman: Goodman and Gilman�s the Pharmacological Basis of therapeutics, McGraw-Hill, New York, NY, USA, 12th edition, 2013.
7. Preet Singh Y, Aggarwal A, Misra R, Agarwal V: Low-dose methotrexate induced pancytopenia. Clin Rheumatol 26: 84-87. 2007
8. Kuitunen T, Malmstr�m J, Palva E, Pettersson T (2005) Pancytopenia induced by low-dose methotrexate. A study of the cases reported to the Finnish Adverse Drug Reaction Register from 1991 to 1999. Scand J Rheumatol 34: 238-241.
9. Leeb B, Witzmann G, Ogris E et al. Folic acid and cyanocobalamin levels in serum and erythrocytes during low dose methotrexate therapy of rheumatoid arthritis and psoriatic arthritis patients. Clin Exp Rheumatol 1995;13:459�63.
10. Bertino JR: Clinical pharmacology of methotrexate. Med Pediatr Oncol 10: 401-411. (1982)
11. Agarwal V, Chauhan S, Singh R, Sachdev A, D�Cruz S, et al.: Pancytopenia with the first dose of methotrexate in a patient with psoriatic arthritis. J Indian Rheumatol Assoc 13: 60-1. (2005)
12. G�ler N, Tander B, Kisacik B, Utku U, Cevlk A, et al. Low Dose Methotrexate Associated Pancytopenia in a Patient with Rheumatoid Arthritis. Turk J Phys Med Rehab 54: 79-81. (2008)
13. Weinblatt ME: Toxicity of low dose methotrexate in rheumatoid arthritis. J Rheumatol Suppl 12: 35-39. (1985)
14. Kondo H, Date Y: Benefit of simultaneous rhG-CSF and methylprednisolone �pulse� therapy for methotrexate-induced bone marrow failure in rheumatoid arthritis. Int J Hematol 65: 159-163. (1997)
15. Olsen EA: The pharmacology of methotrexate. J Am Acad Dermatol 25:306-318. (1991)
16. Sotoudehmanesh R, Anvari B, Akhlaghi M, Shahraeeni S, Kolahdoozan S: Methotrexate Hepatotoxicity in Patients with Rheumatoid Arthritis. Middle East Journal of Digestive Diseases 2: 104-9. (2010)
17. Diouf ML, Diallo S, Mbengue M, Moreira-Diop T : Methotrexate, liver and
rheumatoid arthritis in tropical areas. Sante 11: 195-200. (2001)
18. Kremer JM, Petrillo GF, Hamilton RA: Pharmacokinetics and renal function in patients with rheumatoid arthritis receiving a standard dose of oral weekly methotrexate: association with significant decrease in creatinin clearance and renal clearance of the drug after 6 month of therapy. J Rheumatol 22: 38-40. (1995)
19. Prey S, Paul C: Effect of folic or folinic acid supplementation on methotrexate-associated safety and efficacy in inflammatory disease: a systematic review. Br J Dermatol 160: 622-628. (2009)
20. Kinder AJ, Hassell AB, Brand J, Brownfield A, Grove M, et al.: The treatment of inflammatory arthritis with methotrexate in clinical practice: treatment duration and incidence of adverse drug reactions. Rheumatology (Oxford) 44: 61-66. (2005)
21. Akoun GM, Gauthier-Rahman S, Mayaud CM, Touboul JL, Denis MF:  Leukocyte migration inhibition in methotrexate-induced pneumonitis. Evidence for an immunologic cell-mediated mechanism. Chest 91: 96-99. (1987)
22. Koyama S, Sato E, Takamizawa A, Tsukadaira A, Haniuda M, et al.: Methotrexate stimulates lung epithelial cells to release inflammatory cell chemotactic activities. Exp Lung Res 29: 91-111. (2003)
23. Sato E, Camhi SL, Koyama S, Robbins RA: Methotrexate stimulates lung fibroblasts and epithelial cells to release eosinophil chemotactic activity. J Rheumatol 28: 502-508 (2001)
24. Obayashi Y, Yamadori I, Fujita J, Yoshinouchi T, Ueda N, et al.: The role of neutrophils in the pathogenesis of idiopathic pulmonary fibrosis. Chest 112: 1338-1343. (1997)
25. Kremer JM, Alarc�n GS, Weinblatt ME, Kaymakcian MV, Macaluso M, et al.: Clinical, laboratory, radiographic, and histopathologic features of methotrexate-associated lung injury in patients with rheumatoid arthritis: a multicenter study with literature review. Arthritis Rheum 40: 1829-1837. (1997)
26. Jacobs SA, Stoller RG, Chabner BA, Johns DG: 7-Hydroxymethotrexate as a urinary metabolite in human subjects and rhesus monkeys receiving high dose methotrexate. J Clin Invest 57: 534-538. (1976)
27. Widemann BC, Adamson PC: Understanding and managing methotrexate nephrotoxicity. Oncologist 11: 694-703. (2006)
28. K. G. Saag, G. T. Gim, N. M. Patkar et al.: American College of Rheumatology 2008 recommendations for the use of nonbiologic and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis Arthritis Care and Research, vol. 59, no. 6, pp. 762�784, 2008.
29 J. M. Kremer and J. K. Lee, The safety and efficacy of the use of methotrexate in long-term therapy for rheumatoid arthritis Arthritis and Rheumatism, vol. 29, no. 7, pp. 822�831, 1986. 
30. Katchamart W, Bourr�-Tessier J, Donka T, Drouin J, Rohekar G, et al.: Canadian recommendations for use of methotrexate in patients with rheumatoid arthritis. J Rheumatol 37: 1422-1430. (2010)
31. S. L. Morgan, J. E. Baggott,W. H. Vaughn et al.: Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis. A double-blind, placebo-controlled trial  Annals of Internal Medicine, vol. 121, no. 11, pp. 833�841, 1994.
32. A. N. Colebatch, J. L. Marks, and C. J. Edwards:  Safety of non-steroidal anti-inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving methotrexate for inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis) Cochrane Database of Systematic Reviews, no. 11, 2011.
33. J. M. Kremer and R. A. Hamilton: The effects of nonsteroidal antiinflammatory drugs on methotrexate (MTX) pharmacokinetics: Impairment of renal clearance of MTX at weekly maintenance doses but not at 7.5 mg, Journal of Rheumatology, vol. 22, no. 11, pp. 2072�2077, 1995.
34. Illiger HJ, Bornmann L, Herdrich K Methotrexate. In: Drug interactions in
the therapy of malignant diseases. (3rdedn), Munich: W. Zuckschwerdt Verlag
114-21. (1995)
35. Dean R, Nachman J, Lorenzana AN: Possible methotrexate-mezlocillin interaction. Am J Pediatr Hematol Oncol 14: 88-89. (1992)
36. Najjar TA, Abou-Auda HS, Ghilzai NM: Influence of piperacillin on the pharmacokinetics of methotrexate and hydroxymethotrexate. Cancer Chemother Pharmacol 42: 423-8. (1998)
37. Ga�es E, Trabelsi S, Sahnoun R, Salouage I, Hamza I, et al.  Modification de la pharmacocin�tique du m�thotrexate suite � l�administration d�amphot�ricine B : � propos d�un cas. J Afr Cancer 2: 264-6. (2010)
38. Dalle JH, Auvrignon A, Vassal G, Leverger G, Kalifa C: Methotrexate ciprofloxacin
interaction: report of two cases of severe intoxication. Arch Pediatr 8: 1078-1081. (2001)
39. Suzuki K, Doki K, Homma M, Tamaki H, Hori S, et al.: Co-administration
of proton pump inhibitors delays elimination of plasma methotrexate in highdose
methotrexate therapy. Br J Clin Pharmacol 67: 44-49. (2009)
40. Reid T, Yuen A, Catolico M, Carlson RW: Impact of omeprazole on the
plasma clearance of methotrexate. Cancer Chemother Pharmacol 33: 82-84. (1993)







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