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\ltrch\fcs0 \insrsid16601139  PAGE   \\* MERGEFORMAT }}{\fldrslt {\rtlch\fcs1 \af1 \ltrch\fcs0 \lang1024\langfe1024\noproof\insrsid16542080 17}}}\sectd \ltrsect\linex0\endnhere\sectdefaultcl\sftnbj {\rtlch\fcs1 \af1 \ltrch\fcs0 \insrsid16601139 
\par }\pard \ltrpar\s26\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\tqc\tx4252\tqr\tx8504\wrapdefault\aspalpha\aspnum\faauto\nosnaplinegrid\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \af1 \ltrch\fcs0 \insrsid16601139 
\par }}{\footerf \ltrpar \pard\plain \ltrpar\s26\qc \li0\ri0\sa200\sl276\slmult1\widctlpar\tqc\tx4252\tqr\tx8504\wrapdefault\aspalpha\aspnum\faauto\nosnaplinegrid\adjustright\rin0\lin0\itap0 \rtlch\fcs1 \af1\afs22\alang1025 \ltrch\fcs0 
\f31506\fs22\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\field{\*\fldinst {\rtlch\fcs1 \af1 \ltrch\fcs0 \insrsid16601139  PAGE   \\* MERGEFORMAT }}{\fldrslt {\rtlch\fcs1 \af1 \ltrch\fcs0 \lang1024\langfe1024\noproof\insrsid16601139 1}}}
\sectd \ltrsect\linex0\endnhere\sectdefaultcl\sftnbj {\rtlch\fcs1 \af1 \ltrch\fcs0 \insrsid16601139 
\par }\pard \ltrpar\s26\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\tqc\tx4252\tqr\tx8504\wrapdefault\aspalpha\aspnum\faauto\nosnaplinegrid\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \af1 \ltrch\fcs0 \insrsid16601139 
\par }}{\*\pnseclvl1\pnucrm\pnqc\pnstart1\pnindent720\pnhang {\pntxta .}}{\*\pnseclvl2\pnucltr\pnqc\pnstart1\pnindent720\pnhang {\pntxta .}}{\*\pnseclvl3\pndec\pnqc\pnstart1\pnindent720\pnhang {\pntxta .}}{\*\pnseclvl4\pnlcltr\pnqc\pnstart1\pnindent720\pnhang 
{\pntxta )}}{\*\pnseclvl5\pndec\pnqc\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}{\*\pnseclvl6\pnlcltr\pnqc\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}{\*\pnseclvl7\pnlcrm\pnqc\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}
{\*\pnseclvl8\pnlcltr\pnqc\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}{\*\pnseclvl9\pnlcrm\pnqc\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}\pard\plain \ltrpar\ql \qk10\li0\ri0\sl480\slmult1
\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid7956005 \rtlch\fcs1 \af1\afs22\alang1025 \ltrch\fcs0 \f31506\fs22\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 
\b\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 Evaluation}{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 
\b\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid11673808 \hich\af0\dbch\af31505\loch\f0  }{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 
\b\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 of preventive effects}{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 
\b\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid11673808 \hich\af0\dbch\af31505\loch\f0  }{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 
\b\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 of }{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 
\b\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 Brazilian green propolis}{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 
\b\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid11673808 \hich\af0\dbch\af31505\loch\f0  }{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 
\b\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 on equine herpesvirus 9-induced acute encephalitis 
\par \hich\af0\dbch\af31505\loch\f0 Running head:
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 EVALUATION OF PROPOLIS ON EQUINE HERPESVIRUS 9
\par }\pard \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid13698466 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
Yuya.Tsuchiya}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\super\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 1*}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 , Hoda. A. Abd-Ellatieff}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\super\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 2*}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 , }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 Abdelrahman. A. Abou Rawash}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\super\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 2}{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 , Tokuma.Yanai}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\super\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 1
\par }\pard \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid7956005 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\i\fs24\cf17\lang1033\langfe1041\super\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 1}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \i\f0\fs24\cf17\insrsid16601139\charrsid7956005 
Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Gifu University, 1-1 Yanagido, Gifu}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \i\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 , Japan}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \i\f0\fs24\cf17\insrsid16601139\charrsid7956005  501-1193 }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\i\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \i\fs24\cf17\lang1033\langfe1041\super\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 2}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\i\f0\fs24\cf17\insrsid16601139\charrsid7956005 Department of Pathology and Parasitology, Faculty of Veterinary Medicine, Damanhour University, El-Beheira, Egypt.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\i\fs24\cf17\lang1033\langfe1041\kerning2\loch\af0\hich\af0\dbch\af11\langfenp1041\insrsid16601139\charrsid7956005 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \i\f0\fs24\cf17\insrsid16601139\charrsid7956005 
\par }\pard \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\nowidctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid7956005 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\kerning2\loch\af0\hich\af0\dbch\af11\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af11\loch\f0 *These authors contributed equally to the study.
\par }\pard \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid7956005 {\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \b\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 

\par }{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \b\f0\fs24\cf17\insrsid16601139\charrsid7956005 Corresponding author: 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 TokumaYanai D.V.M., Ph.D., Diplomate of Japanese College of Veterinary Pathologist
\par Laboratory of Veterinary Pathology, Department of Veterinary Medicine,
\par Faculty of Applied Biological Sciences, Gifu University,
\par E-mail:}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\ul\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  y}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\ul\cf17\insrsid16601139\charrsid7956005 anai@gifu-u.ac.jp
\par }\pard \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\nowidctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid7956005 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\kerning2\loch\af0\hich\af0\dbch\af11\langfenp1041\insrsid16601139\charrsid7956005 
\par }\pard \ltrpar\ql \qk10\li0\ri0\sa200\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid7956005 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 
\par }\pard \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid7956005 {\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \b\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\par }\pard \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid396632 {\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \b\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
Abstract}{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \b\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 : }{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 In }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 this study, we aimed to evaluate the }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
preventive effects}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  of Brazilian green propolis on }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 equine}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0  herpesvirus (EHV)}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 -induced encephalitis}{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  in a hamster}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  model}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 . We first investigated the anti}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 viral }{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 activity of Brazilian green propolis against EHV-9}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 ,}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  and 
}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 then, examined }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 the }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 effects }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 of propolis on the }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 kinetics and production of }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 cytokines. }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 Sixty-}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 f}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 
ive male, Syrian hamsters were divided into two treatment groups and control group. }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid7956005 The 1}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\super\insrsid7956005\charrsid7956005 st}{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid7956005  group is a control. }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 The second group was infected intranasally with 50 }{\rtlch\fcs1 \af62\afs24 
\ltrch\fcs0 \i\f62\fs24\cf17\insrsid16601139\charrsid7956005 \'ecl}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 of EHV-9 [3 \'d7 10}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\cf17\super\insrsid16601139\charrsid7956005 4}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005  plaque-forming units (pfu)] without propolis}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid5194899 \hich\af0\dbch\af31505\loch\f0  }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 treatment}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 . The third group received propolis a}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid7956005 
\hich\af0\dbch\af31505\loch\f0 t}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  5000 ppm of }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 e}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 thanol extract of Brazilian green propolis by gavage }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 f}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 or 7 days}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 , }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 followed by}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  intranasal }{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 in}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 oculation }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 with 50 }{\rtlch\fcs1 
\af62\afs24 \ltrch\fcs0 \i\f62\fs24\cf17\insrsid16601139\charrsid7956005 \'ecl}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 of EHV-9 (3 \'d7 10}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\cf17\super\insrsid16601139\charrsid7956005 4 }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 pfu). }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 Pre-treatment with propolis was not effective in preventing EHV-9-induced enc}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid396632 \hich\af0\dbch\af31505\loch\f0 ephalitis via intranasal route. }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 This speculat\hich\af0\dbch\af31505\loch\f0 ion is supported by similar c}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 lin}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 i}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 cal signs and }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 similar immunohistochemistry based on }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 viral antigen}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0  distribution }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 in }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 the }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 brain of infected hamsters in groups 2 and 3 from 3}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\super\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 rd}{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 day post inoculation (}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 dpi}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 )}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 . }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 There were significant increase}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 s}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0  in }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 cerebral }{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 mRNA levels of }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af40\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af40\loch\f0 IL-2, IL-10, and IFN-}{\rtlch\fcs1 \af34\afs24 \ltrch\fcs0 \fs24\cf17\loch\af34\hich\af34\dbch\af41\insrsid16601139\charrsid7956005 \loch\af34\dbch\af41\hich\f34 \u-10187\'3f\u-8450\'3f}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 after propolis administration in the }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 propolis-treated group before and after EHV-9 challenge compared with }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid12673166\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 the }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid12673166 \hich\af0\dbch\af31505\loch\f0 control}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 non-treated group}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 . In conclusion, Brazilian green propolis}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid5194899 
\hich\af0\dbch\af31505\loch\f0  }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 showed no obvious effect on}{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  the pr}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 evention of acute EHV-9-induced acute encephalitis in a hamster model, despite its immune-enhancing activity. }{
\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \b\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\par }\pard \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid10570670 {\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 
\b\i\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 Keywords:}{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 
\i\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid10570670\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 Cytokine}{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 
\i\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid10570670 ,}{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \i\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 EHV-9, Encephalitis, Pathogenesis, Propolis}{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \i\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid12673166 ,}{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 
\b\i\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\par }\pard \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid7956005 {\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \b\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 

\par }{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \b\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139 
\par }{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \b\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid13698466 
\par }{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \b\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid396632 
\par }{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \b\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid396632\charrsid7956005 \sect }\sectd \ltrsect\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj \pard\plain \ltrpar
\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid7956005 \rtlch\fcs1 \af1\afs22\alang1025 \ltrch\fcs0 \f31506\fs22\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 
\b\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 INTRODUCTION
\par }\pard \ltrpar\ql \qk10\fi720\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid16676770 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
Propolis has been widely used in folk medicine for many years as pharmaceuticals or dietary supplement}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 s}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  for the prevention or treatment }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 of}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0  inflammatory diseases }{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 \hich\f0  ADDIN EN.CITE <EndNote><Cite><Author>\'d6
\loch\f0 \hich\f0 zt\'fc\loch\f0 rk</Author><Year>1999</Year><RecNum>1</RecNum><Displa\hich\af0\dbch\af31505\loch\f0 \hich\f0 
yText>(22)</DisplayText><record><rec-number>1</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="0">1</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>\'d6
\loch\f0 \hich\f0 zt\'fc\loch\f0 rk, Far\hich\af0\dbch\af31505\loch\f0 u\hich\af0\dbch\af31505\loch\f0 k</author><author>Kurt, Emin</author><author>Emiro}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16676770 
\loch\af0\dbch\af31505\hich\f0 \u487\'67}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 \hich\f0 lu, Levent</author><author>Sobaci, G\'fc\loch\f0 \hich\f0 ng\'f6\loch\f0 
r</author></authors></contributors><titles><title>Effect of propolis on endotoxin-induced uveitis in rabbits</title><secondary-title>Japanese journal of ophthalmolog\hich\af0\dbch\af31505\loch\f0 
y</secondary-title></titles><pages>285-289</pages><volume>43</volume><number>4</number><dates><year>1999</year></dates><isbn>0021-5155</isbn><urls></urls></record></Cite></EndNote>}}{\fldrslt {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 [}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid16676770 
\hich\af0\dbch\af31505\loch\f0 22}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 ]}}}\sectd \ltrsect
\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
. There are numerous studies on the pharmacological properties and bi\hich\af0\dbch\af31505\loch\f0 ological activities of propolis, including anti-inflammatory, anti}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 -}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
bacterial, anti}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 -}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 fungal, anti}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 -}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
oxidant, anti}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 -}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 cancer, and antiviral effects }{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16676770 
\hich\af0\dbch\af31505\loch\f0  ADDIN EN.CITE <EndNote><Cite><Author>Duran</Author><Year>2011</Year><RecNum>2</RecNum><DisplayText>(5, 19)</Display\hich\af0\dbch\af31505\loch\f0 
Text><record><rec-number>2</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="0">2</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Duran, Nizami</author><author>
\hich\af0\dbch\af31505\loch\f0 M\hich\af0\dbch\af31505\loch\f0 
uz, Mustafa</author><author>Culha, Gulnaz</author><author>Duran, Gulay</author><author>Ozer, Burcin</author></authors></contributors><titles><title>GC-MS analysis and antileishmanial activities of two Turkish propolis types</title><secondary-title>Parasit
\hich\af0\dbch\af31505\loch\f0 o\hich\af0\dbch\af31505\loch\f0 
logy research</secondary-title></titles><pages>95-105</pages><volume>108</volume><number>1</number><dates><year>2011</year></dates><isbn>0932-0113</isbn><urls></urls></record></Cite><Cite><Author>Nina</Author><Year>2015</Year><RecNum>3</RecNum><record><re
\hich\af0\dbch\af31505\loch\f0 c\hich\af0\dbch\af31505\loch\f0 \hich\f0 
-number>3</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="0">3</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Nina, N\'e9\loch\f0 
lida</author><author>Quispe, Cristina</\hich\af0\dbch\af31505\loch\f0 a\hich\af0\dbch\af31505\loch\f0 \hich\f0 uthor><author>Jim\'e9\loch\f0 \hich\f0 nez-Aspee, Felipe</author><author>Theoduloz, Cristina</author><author>Feres\'ed\loch\f0 
n, Gabriela Egly</author><author>Lima, Beatriz</author><author>Leiva, Elba</author><author>Schmeda-Hirschmann, Guillermo</author></authors></contributors><titles\hich\af0\dbch\af31505\loch\f0 >\hich\af0\dbch\af31505\loch\f0 \hich\f0 
<title>Antibacterial activity, antioxidant effect and chemical composition of propolis from the Regi\'f3\loch\f0 
n del Maule, central Chile</title><secondary-title>Molecules</secondary-title></titles><pages>18144-18167</pages><volume>20</volume><number>10</number><da\hich\af0\dbch\af31505\loch\f0 t\hich\af0\dbch\af31505\loch\f0 
es><year>2015</year></dates><urls></urls></record></Cite></EndNote>}}{\fldrslt {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 [}{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 5, 19}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 ]}}}\sectd \ltrsect\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj {\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
. Propolis (bee glue) is a resinous substance collected by honey bees from various plant sources. It is used to seal holes in honeycombs, smooth out the internal walls, and protec\hich\af0\dbch\af31505\loch\f0 t the entrance against intruders.}{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid6581916 \hich\af0\dbch\af31505\loch\f0  }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 Propolis is a bee product that comprises a mixture of polyphenols, flavonoid aglycones, phenolic acids and their esters, and phenolic aldehydes and ketones }{\field{\*\fldinst {\rtlch\fcs1 \af59\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af59\hich\af59\dbch\af31505\insrsid16676770 \hich\af59\dbch\af31505\loch\f59 \hich\f59  ADDIN EN.CITE <EndNote><Cite><Author>Or\'9a\loch\f59 \hich\f59 oli\'e6}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 
</Author><Year>2005</Year><RecNum>4</RecNum><DisplayText>(21)</DisplayText><record><rec-number>4</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="0">4</key></foreign-keys><ref-type name="Journal Article">17</
\hich\af0\dbch\af31505\loch\f0 r}{\rtlch\fcs1 \af59\afs24 \ltrch\fcs0 \fs24\cf17\loch\af59\hich\af59\dbch\af31505\insrsid16676770 \hich\af59\dbch\af31505\loch\f59 \hich\f59 ef-type><contributors><authors><author>Or\'9a\loch\f59 \hich\f59 oli\'e6\loch\f59 
\hich\f59 , Nada</author><author>Terzi\'e6\loch\f59 \hich\f59 , Svjetlana</author><author>\'8a\loch\f59 \hich\f59 ver, Lidija</author><author>Ba\'9a\loch\f59 \hich\f59 i\'e6\loch\f59 , Ivan</author></authors></contributors><titles><title>Honey}{
\rtlch\fcs1 \af34\afs24 \ltrch\fcs0 \fs24\cf17\loch\af34\hich\af34\dbch\af31505\insrsid16676770 \loch\af34\dbch\af31505\hich\f34 \u8208\'2d}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16676770 
\hich\af0\dbch\af31505\loch\f0 bee products in prevention and/or therapy of murine transp\hich\af0\dbch\af31505\loch\f0 
lantable tumours</title><secondary-title>Journal of the Science of Food and Agriculture</secondary-title></titles><pages>363-370</pages><volume>85</volume><number>3</number><dates><year>2005</year></dates><isbn>1097-0010</isbn><urls></urls></record></Cite
\hich\af0\dbch\af31505\loch\f0 >\hich\af0\dbch\af31505\loch\f0 </EndNote>}}{\fldrslt {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 [}{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 21}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 ]}}}\sectd \ltrsect\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj {\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
. It is rich in biochemical constituents, mainly phenolic acid components, which play a role in antiviral activity. It has been reported that constituents such as caffeic acid, }{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 
\i\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 p}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
-coumaric acid, benzoic acid, galangin, pinocembrin, and chry\hich\af0\dbch\af31505\loch\f0 sin may be effective against herpes simplex virus in cell culture}{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 
 ADDIN EN.CITE <EndNote><Cite><Author>Schnitzler</Author><Year>2010</Year><RecNum>5</RecNum><DisplayText>(24, 26)</DisplayText><record><rec-number>5</rec-number><foreign-keys><key app="EN" db\hich\af0\dbch\af31505\loch\f0 
-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="0">5</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Schnitzler, Paul</author><author>Neuner, Annett</author><author>Nolkemper, Silke</author><author>Zu
\hich\af0\dbch\af31505\loch\f0 n\hich\af0\dbch\af31505\loch\f0 \hich\f0 del, Christine</author><author>Nowack, Hans</author><author>Sensch, Karl Heinz</author><author>Reichling, J\'fc\loch\f0 
rgen</author></authors></contributors><titles><title>Antiviral activity and mode of action of propolis extracts and selected compounds</title><seco\hich\af0\dbch\af31505\loch\f0 n\hich\af0\dbch\af31505\loch\f0 
dary-title>Phytotherapy Research</secondary-title></titles><volume>24</volume><number>S1</number><dates><year>2010</year></dates><isbn>1099-1573</isbn><urls></urls></record></Cite><Cite><Author>Silva-Carvalho</Author><Year>2015</Year><RecNum>6</RecNum><re
\hich\af0\dbch\af31505\loch\f0 c\hich\af0\dbch\af31505\loch\f0 
ord><rec-number>6</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="0">6</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Silva-Carvalho, Ricardo</author><author
\hich\af0\dbch\af31505\loch\f0 >\hich\af0\dbch\af31505\loch\f0 \hich\f0 Baltazar, F\'e1\loch\f0 
tima</author><author>Almeida-Aguiar, Cristina</author></authors></contributors><titles><title>Propolis: a complex natural product with a plethora of biological activities that can be explored for drug development</title><secondary-title>Eviden
\hich\af0\dbch\af31505\loch\f0 c\hich\af0\dbch\af31505\loch\f0 e-based complementary and alternative medicine</secondary-title></titles><volume>2015</volume><dates><year>2015</year></dates><isbn>1741-427X</isbn><urls></urls></record></Cite></EndNote>}
}{\fldrslt {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 [}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 24, 26}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 
\hich\af0\dbch\af31505\loch\f0 ]}}}\sectd \ltrsect\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 .Propolis and its derivatives have the ability to inhibit \hich\af0\dbch\af31505\loch\f0 
virus propagation via reduction of viral multiplication and virucidal action. Several studies have shown the effect of propolis on the RNA and DNA of different viruses}{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 
\i\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  in vitro}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 , including herpes simplex type 1, herpes simplex type 2, adenovirus type 2, pol\hich\af0\dbch\af31505\loch\f0 iovirus type 2, vesicular stomatitis virus }{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid328807 \hich\af0\dbch\af31505\loch\f0 
 ADDIN EN.CITE <EndNote><Cite><Author>Amoros</Author><Year>1992</Year><RecNum>7</RecNum><DisplayText>(1)</DisplayText><record><rec-number>7</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0w\hich\af0\dbch\af31505\loch\f0 
xf0rx9sp92" timestamp="0">7</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Amoros, M</author><author>Sauvager, F</author><author>Girre, L</author><author>Cormier, M</author></authors></contributors><titles
\hich\af0\dbch\af31505\loch\f0 >\hich\af0\dbch\af31505\loch\f0 
<title>In vitro antiviral activity of propolis</title><secondary-title>Apidologie</secondary-title></titles><pages>231-240</pages><volume>23</volume><number>3</number><dates><year>1992</year></dates><isbn>0044-8435</isbn><urls></urls></record></Cite></End
\hich\af0\dbch\af31505\loch\f0 N\hich\af0\dbch\af31505\loch\f0 ote>}}{\fldrslt {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 [}{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid328807 \hich\af0\dbch\af31505\loch\f0 1}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 ]}}}\sectd \ltrsect\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj {\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 , vaccinia virus, and the virus responsible for Newcastle disease}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid12670252 \hich\af0\dbch\af31505\loch\f0  }{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 
 ADDIN EN.CITE <EndNote><Cite><Author>Maksimova-Todorova V</Author><Year>1985</Year><RecNum>8</RecNum><DisplayText>(14)</DisplayText><record><rec-number>8</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="0">8
\hich\af0\dbch\af31505\loch\f0 <\hich\af0\dbch\af31505\loch\f0 
/key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Maksimova-Todorova V,Manolova N, Gegova G, Serkedzhieva Y, Uzunov S, Pancheva S, Marekov N, Bankova V. </author></authors></contributors><titles><title> Antiv
\hich\af0\dbch\af31505\loch\f0 i\hich\af0\dbch\af31505\loch\f0 ral effects of some fractions isolated from propolis. </title><secondary-title>ActaMicrobiolog. Bulgarica </secondary-title></titles><volume>17:79\hich\f0 \endash \loch\f0 
85.</volume><dates><year>1985</year></dates><urls></urls></record></Cite></EndNote>}}{\fldrslt {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 [}{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 14}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 ]}}}\sectd \ltrsect\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj {\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 . Propolis has been\hich\af0\dbch\af31505\loch\f0  used as a potential immune regulator}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid12670252 \hich\af0\dbch\af31505\loch\f0  }{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 
 ADDIN EN.CITE <EndNote><Cite><Author>Marcucci</Author><Year>2001</Year><RecNum>9</RecNum><DisplayText>(2, 15)</DisplayText><record><rec-number>9</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0}{\rtlch\fcs1 \af63\afs24 
\ltrch\fcs0 \fs24\cf17\loch\af63\hich\af63\dbch\af31505\insrsid16676770 \hich\af63\dbch\af31505\loch\f63 \hich\f63 
wxf0rx9sp92" timestamp="0">9</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Marcucci, MC</author><author>Ferreres, F</author><author>Garc\'fd\loch\f63 
a-Viguera, C</author><author>Bankova, VS</author><author>De Castro,\hich\af63\dbch\af31505\loch\f63  }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 
SL</author><author>Dantas, AP</author><author>Valente, PHM</author><author>Paulino, N</author></authors></contributors><titles><title>Phenolic compounds from Brazilian propolis with pharmacological activities</title><secondary-title>Journal of ethnopharma
\hich\af0\dbch\af31505\loch\f0 c\hich\af0\dbch\af31505\loch\f0 \hich\f0 
ology</secondary-title></titles><pages>105-112</pages><volume>74</volume><number>2</number><dates><year>2001</year></dates><isbn>0378-8741</isbn><urls></urls></record></Cite><Cite><Author>Bonveh\'ed\loch\f0 
</Author><Year>2013</Year><RecNum>10</RecNum><record><rec-nu\hich\af0\dbch\af31505\loch\f0 m\hich\af0\dbch\af31505\loch\f0 \hich\f0 
ber>10</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="0">10</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bonveh\'ed\loch\f0 
, J Serra</author><author>Bermejo, FJ Oran\hich\af0\dbch\af31505\loch\f0 t\hich\af0\dbch\af31505\loch\f0 
es</author></authors></contributors><titles><title>Element content of propolis collected from different areas of South Spain</title><secondary-title>Environmental monitoring and assessment</secondary-title></titles><pages>6035-6047</pages><volume>185</vol
\hich\af0\dbch\af31505\loch\f0 u\hich\af0\dbch\af31505\loch\f0 me><number>7</number><dates><year>2013</year></dates><isbn>0167-6369</isbn><urls></urls></record></Cite></EndNote>}}{\fldrslt {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 [}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid16676770 
\hich\af0\dbch\af31505\loch\f0 2, 15}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 ]}}}\sectd \ltrsect
\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
. Recently, it was reported that Brazilian green propolis has immune enhancing action both }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \i\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 in vitro}{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  and }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\i\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 in vivo}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \i\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid12670252 \hich\af0\dbch\af31505\loch\f0  }
{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 
 ADDIN EN.CITE <EndNote><Cite><Author>Sforcin</Author><Year>2007</Year><RecNum>11</RecNum><DisplayText>(12, 25)</DisplayText><record><rec-number>11</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="0">11</key>
\hich\af0\dbch\af31505\loch\f0 <\hich\af0\dbch\af31505\loch\f0 
/foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sforcin, JM</author></authors></contributors><titles><title>Propolis and the immune system: a review</title><secondary-title>Journal of ethnopharmacology</secondary
-\hich\af0\dbch\af31505\loch\f0 
title></titles><pages>1-14</pages><volume>113</volume><number>1</number><dates><year>2007</year></dates><isbn>0378-8741</isbn><urls></urls></record></Cite><Cite><Author>Gao</Author><Year>2014</Year><RecNum>12</RecNum><record><rec-number>12</rec-number><fo
\hich\af0\dbch\af31505\loch\f0 r\hich\af0\dbch\af31505\loch\f0 
eign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="0">12</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Gao, Weina</author><author>Wu, Jianquan</author><author>Wei, Jingyu</aut
\hich\af0\dbch\af31505\loch\f0 h\hich\af0\dbch\af31505\loch\f0 
or><author>Pu, Lingling</author><author>Guo, Changjiang</author><author>Yang, Jijun</author><author>Yang, Ming</author><author>Luo, Haiji</author></authors></contributors><titles><title>Brazilian green propolis improves immune function in aged mice</title
\hich\af0\dbch\af31505\loch\f0 >\hich\af0\dbch\af31505\loch\f0 
<secondary-title>Journal of clinical biochemistry and nutrition</secondary-title></titles><pages>7-10</pages><volume>55</volume><number>1</number><dates><year>2014</year></dates><isbn>0912-0009</isbn><urls></urls></record></Cite></EndNote>}}{\fldrslt {
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 [}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 12, 25}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 
\hich\af0\dbch\af31505\loch\f0 ]}}}\sectd \ltrsect\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 .}{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\par }\pard \ltrpar\ql \fi720\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid16676770 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 Equine herpesvirus-9 (EHV-9), a varicellovirus belonging to the subfamily Alpha-herpesvirinae, is the newest member of EHV and is closely related toEHV-1. EHV-9 was first described in an outbreak of disease in Thomson
\hich\f0 \rquote \loch\f0 s gazelles (}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \i\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 Gazellathomsonii}{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 ) in a Japanese zoo}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid12670252 \hich\af0\dbch\af31505\loch\f0  }{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 
 ADDIN EN.CITE <EndNote><Cite><Author>Fukushi</Author><Year>1997</Year><RecNum>33</RecNum><DisplayText>(11, 32)</DisplayText><record><rec-number>33</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" tim
\hich\af0\dbch\af31505\loch\f0 
estamp="1521036769">33</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Fukushi, H., Tomita, T., Taniguchi, A., Ochiai, Y., Kirisawa, R., Matsumura, T., Yanai, T., Masegi, T., Yamaguchi, T. and Hirai, K</aut
\hich\af0\dbch\af31505\loch\f0 h\hich\af0\dbch\af31505\loch\f0 
or></authors></contributors><titles><title> Gazelle herpesvirus 1: a new neurotropic herpesvirus immunologically related to equine herpesvirus 1</title><secondary-title>Virology </secondary-title></titles><periodical><full-title>Virology</full-title></per
\hich\af0\dbch\af31505\loch\f0 i\hich\af0\dbch\af31505\loch\f0 
odical><volume>227: 34-44</volume><dates><year>1997</year></dates><urls></urls></record></Cite><Cite><Author>Yanai</Author><Year>1998</Year><RecNum>34</RecNum><record><rec-number>34</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0w
\hich\af0\dbch\af31505\loch\f0 x\hich\af0\dbch\af31505\loch\f0 
f0rx9sp92" timestamp="1521036882">34</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Yanai, T., Sakai, T., Fukushi, H., Hirai, K., Narita, M., Sakai, H. and Masegi, T. </author></authors></contributors><tit
\hich\af0\dbch\af31505\loch\f0 l\hich\af0\dbch\af31505\loch\f0 es><title> Neuropathological study of gazelle herpesvirus 1 (equine herpesvirus 9) infection in Thomson\hich\f0 \rquote \loch\f0 
s gazelles (Gazella thomsoni)</title><secondary-title>J. Comp. Pathol</secondary-title></titles><periodical><full-title>J. Comp. Pathol</full-title></p\hich\af0\dbch\af31505\loch\f0 e\hich\af0\dbch\af31505\loch\f0 
riodical><volume>119: 159-168</volume><dates><year>1998</year></dates><urls></urls></record></Cite></EndNote>}}{\fldrslt {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\langfenp1041\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 [}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\langfenp1041\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 11, 32}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\langfenp1041\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 ]}}}\sectd \ltrsect\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj {\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid328807 \hich\af0\dbch\af31505\loch\f0 . }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid5586095 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 Emerging EHV-9 infection in domestic animals is also a concern, }{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid1207665\charrsid1207665 \hich\af0\dbch\af31505\loch\f0 as }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid5586095 
\hich\af0\dbch\af42\loch\f0 various }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid1207665\charrsid1207665 \hich\af0\dbch\af42\loch\f0 domestic }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\loch\af0\hich\af0\dbch\af42\insrsid1207665 \hich\af0\dbch\af42\loch\f0 animals can be easily infected }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 via nasal route}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid12670252 \hich\af0\dbch\af31505\loch\f0  }{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16676770 \hich\af0\dbch\af31505\loch\f0  ADDIN EN.CITE }{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
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6b61692c20482e20616e64204d61736567692c20543c2f617574686f723e3c2f617574686f72733e3c2f636f6e7472696275746f72733e3c7469746c65733e3c7469746c653e4578706572696d656e74616c20696e66656374696f6e206f6620657175696e65206865727065737669727573203920696e20646f67733c2f74
69746c653e3c7365636f6e646172792d7469746c653e205665742e20506174686f6c3c2f7365636f6e646172792d7469746c653e3c2f7469746c65733e3c766f6c756d653e34303a203236332d3236372e3c2f766f6c756d653e3c64617465733e3c796561723e20323030333c2f796561723e3c2f64617465733e3c75726c
733e3c2f75726c733e3c2f7265636f72643e3c2f436974653e3c2f456e644e6f74653e00006800}}}{\fldrslt {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\langfenp1041\insrsid11673808 
\hich\af0\dbch\af31505\loch\f0 [}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\langfenp1041\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 6, 28, 29, 31}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\langfenp1041\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 ]}}}\sectd \ltrsect\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj {\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
.The pathogenesis of EHV-9 following nasal infection has been studied in a suckling hamster model }{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16676770 
\hich\af0\dbch\af31505\loch\f0  ADDIN EN.CITE <EndNote><Cite><Author>El-Habashi</Author><Year>2011</Year><RecNum>35</RecNum><DisplayText>(6)</DisplayText><record><rec-numbe\hich\af0\dbch\af31505\loch\f0 
r>35</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="1521038974">35</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>El-Habashi, N., El-Nahass, E.S., Namihira,
\hich\af0\dbch\af31505\loch\f0  \hich\af0\dbch\af31505\loch\f0 
Y., Hagiwara, H., Fukushi, H., Narita, M., Hirata, A., Sakai, H. and Yanai, T</author></authors></contributors><titles><title>  Neuropathogenicity of equine herpesvirus 9 in cattle</title><secondary-title> J. Equine Vet. Sci</secondary-title></titles><vol
\hich\af0\dbch\af31505\loch\f0 u\hich\af0\dbch\af31505\loch\f0 me>31: 72-77.</volume><dates><year>2011</year></dates><urls></urls></record></Cite></EndNote>}}{\fldrslt {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\langfenp1041\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 [}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\langfenp1041\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 6}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\langfenp1041\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 ]}}}\sectd \ltrsect\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj {\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 . }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 EHV-9 propaga}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 ted in the olfactory epithelium within few hours (12-24/hrs) }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 gained access to the brain through the olfactory and trigeminal nerves}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid12670252 \hich\af0\dbch\af31505\loch\f0  }{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16676770 \hich\af0\dbch\af31505\loch\f0  ADDIN EN.\hich\af0\dbch\af31505\loch\f0 
CITE <EndNote><Cite><Author>El-Habashi</Author><Year>2011</Year><RecNum>35</RecNum><DisplayText>(6, 32)</DisplayText><record><rec-number>35</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="1521038974">35</key
\hich\af0\dbch\af31505\loch\f0 >\hich\af0\dbch\af31505\loch\f0 
</foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>El-Habashi, N., El-Nahass, E.S., Namihira, Y., Hagiwara, H., Fukushi, H., Narita, M., Hirata, A., Sakai, H. and Yanai, T</author></authors></contributors><titles><
\hich\af0\dbch\af31505\loch\f0 t\hich\af0\dbch\af31505\loch\f0 
itle>  Neuropathogenicity of equine herpesvirus 9 in cattle</title><secondary-title> J. Equine Vet. Sci</secondary-title></titles><volume>31: 72-77.</volume><dates><year>2011</year></dates><urls></urls></record></Cite><Cite><Author>Yanai</Author><Year>199
\hich\af0\dbch\af31505\loch\f0 8\hich\af0\dbch\af31505\loch\f0 
</Year><RecNum>34</RecNum><record><rec-number>34</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="1521036882">34</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><autho
\hich\af0\dbch\af31505\loch\f0 r\hich\af0\dbch\af31505\loch\f0 
>Yanai, T., Sakai, T., Fukushi, H., Hirai, K., Narita, M., Sakai, H. and Masegi, T. </author></authors></contributors><titles><title> Neuropathological study of gazelle herpesvirus 1 (equine herpesvirus 9) infection in Thomson\hich\f0 \rquote \loch\f0 
s gazelles (Gazella thomsoni\hich\af0\dbch\af31505\loch\f0 )\hich\af0\dbch\af31505\loch\f0 
</title><secondary-title>J. Comp. Pathol</secondary-title></titles><periodical><full-title>J. Comp. Pathol</full-title></periodical><volume>119: 159-168</volume><dates><year>1998</year></dates><urls></urls></record></Cite></EndNote>}}{\fldrslt {
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\langfenp1041\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 [}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\langfenp1041\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 6, 32}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\langfenp1041\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 ]}}}\sectd \ltrsect\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj {\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16676770 .}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid16601139\charrsid5586095 
\par }\pard \ltrpar\ql \qk10\fi720\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\cufi300\pararsid5586095 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 In the present study, we investigated the }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
preventive }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 effects of Brazilian green propolis on}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 EHV-9-induced acute encephalitis as well as its }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 immune}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0  activation }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 function}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 s}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0  by measuring cytokine levels}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid15807810 .}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\par }\pard \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid7956005 {\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \b\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
MATERIAL AND METHODS
\par }{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\f0\fs24\cf17\insrsid16601139\charrsid396632 Animals
\par }\pard \ltrpar\ql \qk10\fi720\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid13698466 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 Sixty five, 4-week-old male, s
pecific pathogen-free Syrian hamsters (}{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\f0\fs24\cf17\insrsid16601139\charrsid7956005 Mesocricetusauratus}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 
) were used in this study. The animals were purchased from a}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
n experimental animal}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005  breeder (SLC Inc., Hamamatsu, Japan). All animal experiments were performed according to the code of ethics of Resea
rch and Animal Resources Committee, Faculty of Applied biological science, Gifu University, Japan, approved by Gifu }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 U}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 niversity }{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 A}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 nimal }{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 E}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\cf17\insrsid16601139\charrsid7956005 xperiment }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 C}{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 ommittee. }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
The animals were kept in a well-ventilated room at 22\hich\f0 \endash \loch\f0 24}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af43\insrsid16601139\charrsid7956005 \loch\af0\dbch\af43\hich\f0 \'b0}{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 C and 50% relative humidity, with 12 h}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid10570670 
\hich\af0\dbch\af31505\loch\f0 r}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 /12 h}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid10570670 \hich\af0\dbch\af31505\loch\f0 r}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  light}{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 /}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 dark cycle. Food and water were provided }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\i\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 ad libitum}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 . After acclimation for 5 days,}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005  they were randomly divided into three groups:}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\cf17\insrsid12670252  }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 (}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid14884136 Group}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\cf17\insrsid16601139\charrsid7956005 1) control non}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 -}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\cf17\insrsid16601139\charrsid7956005 treated group (20}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 animals}{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid13698466 ), }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid14884136\charrsid7956005 (}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid14884136 Group2}{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \f0\fs24\cf17\insrsid14884136\charrsid7956005 ) }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
EHV-9 inoculated without propolis}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 treatment group }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 [}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 20}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  animals}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid13698466 ), and }{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \f0\fs24\cf17\insrsid14884136\charrsid7956005 (}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid14884136 Group3}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid14884136\charrsid7956005 ) }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\cf17\insrsid16601139\charrsid7956005 propolis treated }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
and EHV-9 inoculated group }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 (2}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid13698466 5}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 animals}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 ).}{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \f0\fs24\cf17\insrsid14884136 
\par }\pard \ltrpar\ql \qk10\li0\ri0\sa200\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid14884136 {\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\f0\fs24\cf17\insrsid14884136\charrsid396632 Virus seed}{\rtlch\fcs1 
\ai\af0\afs24 \ltrch\fcs0 \i\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid14884136\charrsid396632 
\par }\pard \ltrpar\ql \qk10\fi720\li0\ri0\sa200\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid13698466 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid14884136\charrsid7956005 
Original seed stocks of EHV-9 [P19, 5th 102 }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid13698466\charrsid7956005 passages}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid14884136\charrsid7956005 
 in Madine-Derby bovine kidney cells (MDBK)}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid14884136\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 ]}{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid12670252 \hich\af0\dbch\af31505\loch\f0  }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid13698466 are}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\cf17\insrsid14884136\charrsid7956005  the source of inocula of virus infection used in this experiment. The viruses were titrated by plaque assay in MDBK cells, which were used for virus propagation.}{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 
\b\f0\fs24\cf17\insrsid14884136\charrsid7956005 
\par }\pard \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid15935106 {\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\f0\fs24\cf17\insrsid14884136\charrsid14884136 Experimental design
\par }\pard \ltrpar\ql \qk10\fi720\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid10570670 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid15935106 Group 1}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\cf17\insrsid16601139\charrsid7956005  and group }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid15935106 2 }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 were }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\cf17\insrsid15935106 intranasally}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid6581916  }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 inoculated with 50 }{\rtlch\fcs1 \af62\afs24 \ltrch\fcs0 
\i\f62\fs24\cf17\insrsid16601139\charrsid7956005 \'ecl}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \i\f0\fs24\cf17\insrsid13698466  (}{\rtlch\fcs1 \af62\afs24 \ltrch\fcs0 \f62\fs24\cf17\insrsid16601139\charrsid7956005 MEM\endash \'e1) divid}{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 ed between both nostrils for 7 days}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 .}{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid6581916  }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid15935106 Group 3 }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid15935106\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 received propolis as 5000 ppm of ethanol extract of Brazilian green propolis (obtained from API Co., Ltd. Gifu, Japan) by gavage for 7 days}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid15935106 .}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid12670252 \hich\af0\dbch\af31505\loch\f0  }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid15935106 
From 8}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\super\insrsid15935106\charrsid15935106 th}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid15935106  day from the start of the experiment, Group 2}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\cf17\insrsid15935106\charrsid7956005  and group }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid15935106 3 were }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 infected intranasally with 50 }{
\rtlch\fcs1 \af62\afs24 \ltrch\fcs0 \i\f62\fs24\cf17\insrsid16601139\charrsid7956005 \'ecl}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \i\f0\fs24\cf17\insrsid12670252  }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 of EHV-9 [3 
\'d7 10}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\super\insrsid16601139\charrsid7956005 4}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005  plaque forming units (pfu)]}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 . }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 Each group was housed separat}{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \f0\fs24\cf17\insrsid5271779 ely to prevent cross-infection. }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid5271779\charrsid7956005 
The experimental animals were kept under observation daily until the end of the experiment for appearance of any clinical signs post viral infection.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid12670252  }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\cf17\insrsid16601139\charrsid7956005 Five hamsters from }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid15935106 group 3}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 
 were euthanized before viral challenge by 12 hr. Five hamsters from each of the three groups were euthanized at 2}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\super\insrsid16601139\charrsid7956005 nd}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\cf17\insrsid16601139\charrsid7956005 , 3}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\super\insrsid16601139\charrsid7956005 rd}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 , 4}{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \f0\fs24\cf17\super\insrsid16601139\charrsid7956005 th}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005  and 5}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\super\insrsid16601139\charrsid7956005 th}{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005  dpi, and the samples/specimens were immediately collected }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 (Table 1)}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 . }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\par }\pard \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid7956005 {\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\f0\fs24\cf17\insrsid16601139\charrsid396632 Necropsy and postmortem examination
\par }\pard \ltrpar\ql \qk10\fi720\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid7956005 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 
Euthanasia was performed by intraperitoneal administration of pentobarbital sodium (100 mg/kg). }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 The b}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 rains, heart, lung}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 s}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 , kidney}{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 s}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 
, liver, and spleen were removed and examined for gross lesions. The brain was divided into two halves}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 . O}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 
ne-half of the brain was collected in sterilized Eppendorf tubes containing RNA for RNA and DNA extraction. The second half of the brain and suitable s
pecimens from other organs were immediately fixed in 10% buffered paraformaldehyde (average period of fixation was 3}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \loch\af0\dbch\af31505\hich\f0 \endash }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 4 days at 24 \'ba
C for routine paraffin section preparation and histopathological and immunohistochemical examination. }{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \b\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 

\par }\pard \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid7956005 {\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\f0\fs24\cf17\insrsid16601139\charrsid396632 RNA extraction for viral and inflammatory cytokine detection

\par }\pard \ltrpar\ql \qk10\fi720\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid16676770 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af40\insrsid16601139\charrsid7956005 \hich\af0\dbch\af40\loch\f0 
Total RNA extraction from}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  the }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\cf17\insrsid16601139\charrsid7956005 brain and lung tissues was performed according to the Qiagen All Prep DNA/RNA/Protein Mini kit protocol. }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af40\insrsid16601139\charrsid7956005 \hich\af0\dbch\af40\loch\f0 Total RNA samples were reverse transcribed by using QuantiTectR Reverse Transcript\hich\af0\dbch\af40\loch\f0 
ion Kit (Germany). cDNA was then used for EHV-9 detection using its specific primers}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af40\insrsid12670252 \hich\af0\dbch\af40\loch\f0  }{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af40\insrsid16676770 \hich\af0\dbch\af40\loch\f0 
 ADDIN EN.CITE <EndNote><Cite><Author>Saleh</Author><Year>2017</Year><RecNum>29</RecNum><DisplayText>(23)</DisplayText><record><rec-number>29</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="1520600788">29</k
\hich\af0\dbch\af40\loch\f0 e\hich\af0\dbch\af40\loch\f0 
y></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Saleh, Asmaa G</author><author>Anwar, Shehata I</author><author>Abas, Osama M</author><author>Abd-Ellatieff, Hoda A</author><author>Nasr, Mohamed</author><author
\hich\af0\dbch\af40\loch\f0 >\hich\af0\dbch\af40\loch\f0 
Saleh, Ibrahim</author><author>Fukushi, Hideto</author><author>Yanai, Tokuma</author></authors></contributors><titles><title>Effect of a single point mutation on equine herpes virus 9 (EHV-9) neuropathogenicity after intranasal inoculation in a hamster mo
\hich\af0\dbch\af40\loch\f0 d\hich\af0\dbch\af40\loch\f0 
el</title><secondary-title>Journal of Veterinary Medical Science</secondary-title></titles><periodical><full-title>Journal of Veterinary Medical Science</full-title></periodical><pages>1426-1436</pages><volume>79</volume><number>8</number><dates><year>201
\hich\af0\dbch\af40\loch\f0 7\hich\af0\dbch\af40\loch\f0 </year></dates><isbn>0916-7250</isbn><urls></urls></record></Cite></EndNote>}}{\fldrslt {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af40\noproof\insrsid11673808 \hich\af0\dbch\af40\loch\f0 [}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af40\noproof\insrsid16676770 
\hich\af0\dbch\af40\loch\f0 23}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af40\noproof\insrsid11673808 \hich\af0\dbch\af40\loch\f0 ]}}}\sectd \ltrsect
\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af40\insrsid16601139\charrsid7956005 \hich\af0\dbch\af40\loch\f0 
 , and  interleukin (IL)-2, IL-10, and interferon gamma (IFN-}{\rtlch\fcs1 \af34\afs24 \ltrch\fcs0 \fs24\cf17\loch\af34\hich\af34\dbch\af41\insrsid16601139\charrsid7956005 \loch\af34\dbch\af41\hich\f34 \u-10187\'3f\u-8450\'3f}{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af40\insrsid16601139\charrsid7956005 \hich\af0\dbch\af40\loch\f0 ) using hamster-speci}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af11\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af11\loch\f0 f}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af40\insrsid16601139\charrsid7956005 \hich\af0\dbch\af40\loch\f0 ic primers}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af40\insrsid12670252 \hich\af0\dbch\af40\loch\f0  }{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af40\insrsid16676770 \hich\af0\dbch\af40\loch\f0 
 ADDIN EN.CITE <EndNote><Cite><Author>Escobedo</Author><Year>2012</Year><RecN\hich\af0\dbch\af40\loch\f0 
um>27</RecNum><DisplayText>(8, 30)</DisplayText><record><rec-number>27</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="1520600344">27</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contri
\hich\af0\dbch\af40\loch\f0 b\hich\af0\dbch\af40\loch\f0 \hich\f0 utors><authors><author>Escobedo, Galileo</author><author>Palacios-Arreola, M Isabel</author><author>Olivos, Alfonso</author><author>L\'f3\loch\f0 
pez-Griego, Lorena</author><author>Morales-Montor, Jorge</author></authors></contributors><titles><title>Tamoxifen treatm\hich\af0\dbch\af40\loch\f0 e\hich\af0\dbch\af40\loch\f0 
nt in hamsters induces protection during taeniosis by Taenia solium</title><secondary-title>BioMed research international</secondary-title></titles><periodical><full-title>BioMed research international</full-title></periodical><volume>2013</volume><dates>
\hich\af0\dbch\af40\loch\f0 <\hich\af0\dbch\af40\loch\f0 
year>2012</year></dates><isbn>2314-6133</isbn><urls></urls></record></Cite><Cite><Author>Vernel-Pauillac</Author><Year>2006</Year><RecNum>15</RecNum><record><rec-number>15</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92
\hich\af0\dbch\af40\loch\f0 "\hich\af0\dbch\af40\loch\f0 \hich\f0  timestamp="0">15</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Vernel-Pauillac, Fr\'e9\loch\f0 \hich\f0 d\'e9\loch\f0 
rique</author><author>Merien, Fabrice</author></authors></contributors><titles><title>Proinflammatory and immunomodula\hich\af0\dbch\af40\loch\f0 t\hich\af0\dbch\af40\loch\f0 
ory cytokine mRNA time course profiles in hamsters infected with a virulent variant of Leptospira interrogans</title><secondary-title>Infection and immunity</secondary-title></titles><periodical><full-title>Infection and immunity</full-title></periodical>
\hich\af0\dbch\af40\loch\f0 <\hich\af0\dbch\af40\loch\f0 pages>4172-4179</pages><volume>74</volume><number>7</number><dates><year>2006</year></dates><isbn>0019-9567</isbn><urls></urls></record></Cite></EndNote>}}{\fldrslt {\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af40\noproof\insrsid11673808 \hich\af0\dbch\af40\loch\f0 [}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af40\noproof\insrsid16676770 
\hich\af0\dbch\af40\loch\f0 8, 30}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af40\noproof\insrsid11673808 \hich\af0\dbch\af40\loch\f0 ]}}}\sectd \ltrsect
\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af40\insrsid16601139\charrsid7956005 \hich\af0\dbch\af40\loch\f0  .}{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af40\langfenp1041\insrsid16601139\charrsid7956005 
\par }\pard \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid7956005 {\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\f0\fs24\cf17\insrsid16601139\charrsid396632 Real-time PCR and amplification protocol
\par }\pard \ltrpar\ql \qk10\fi720\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid10570670 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 PCR amplification and analysis were pe
rformed using Takara Thermal Cycler. Dice Real Time System with version 4.0 software. All reactions were performed with the Thermal Cycler Dice single Dice. In this study, DNA master SYBR green I kit was used [Takara Clontech, SYBR}{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\super\insrsid16601139\charrsid7956005 R}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005  premix Ex Taq}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\cf17\super\insrsid16601139\charrsid7956005 TM}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 (TliRNaseH plus)] at a volume of 25 }{\rtlch\fcs1 \af62\afs24 \ltrch\fcs0 
\i\f62\fs24\cf17\insrsid16601139\charrsid7956005 \'ecl}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \i\f0\fs24\cf17\insrsid12670252  }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 
in each reaction capillary. For quantification of cytokines, 5 }{\rtlch\fcs1 \af62\afs24 \ltrch\fcs0 \i\f62\fs24\cf17\insrsid16601139\charrsid7956005 \'ecl}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \i\f0\fs24\cf17\insrsid12670252  }{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 of cDNA was added before the capillaries were capped, centrifuged, and placed in Light Cycler sample carousel. The amplification conditions of the target cDNA was for 40 cycles (95\'b0C for 30 se}{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid10570670 c}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 , 95\'b0C for 10 sec, and 60\'b0C for 10 sec, and a variable extension time at 72\'b0
C for10 sec). Dissociation curve analysis was performed immediately after amplification with continuous fluorescence acquisition.
\par }\pard \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid7956005 {\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\f0\fs24\cf17\insrsid16601139\charrsid396632 Histopathological and immunohistochemical}{\rtlch\fcs1 
\ai\af0\afs24 \ltrch\fcs0 \i\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid396632 \hich\af0\dbch\af31505\loch\f0 e}{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\f0\fs24\cf17\insrsid16601139\charrsid396632 
xamination
\par }\pard \ltrpar\ql \qk10\fi720\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid5586095 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 The b}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 
rain, heart, lungs, liver, spleen, and kidneys were collected immediately after necropsy and fixed in 10% buffered paraformaldehyde. After fixation, the organs and tissues were dehydrated and embedded in paraffin wax, sectioned }{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 into 3-}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\i\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \loch\af0\dbch\af31505\hich\f0 \'b5\loch\f0 m }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 sections,}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005  stained 
with hematoxylin and eosin (HE), and examined under a light microscope. }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 Paraffin-embedded sections (4 }{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \i\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \loch\af0\dbch\af31505\hich\f0 \'b5\loch\f0 m}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 ) of the brain was immunolabeled with EHV-9 rabbit antiserum}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 
 using the En Vision+ System HRP-labeled polymer }{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 (Dako) .}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 The primary antibody was EHV-9 anti\hich\af0\dbch\af31505\loch\f0 
serum used at a dilution of 1:800.Subsequently, a secondary antibody (biotinylated anti-rabbit IgG, DAKO Cytomation, USA) was applied, with Liquid Diaminobenzidine (DAB) Substrate Chromogen System (DAKO Cytomation) used as the chromogen and hematoxylin as
\hich\af0\dbch\af31505\loch\f0  \hich\af0\dbch\af31505\loch\f0 the counterstain, }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 as described previously}{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\cf17\insrsid5586095  ADDIN EN.CITE <EndNote><Cite><Author>El-Habashi</Author><Year>2013</Year><RecNum>17</RecNum><DisplayText>(7)</DisplayText><record><rec-number>17</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv
0e0wxf0rx9sp92" timestamp="0">17</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>El-Habashi, N</author><author>Kato, Y</author><author>El-Nahass, E</author><author>Fukushi, H</author><author>Hirata, A</auth
o
r><author>Sakai, H</author><author>Kimura, J</author><author>Yanai, T</author></authors></contributors><titles><title>An Ocular Infection Model Using Suckling Hamsters Inoculated With Equine Herpesvirus 9 (EHV-9) Kinetics of the Virus and Time-Course Path
ogenesis of EHV-9\endash 
Induced Encephalitis via the Eyes</title><secondary-title>Veterinary Pathology</secondary-title></titles><pages>56-64</pages><volume>50</volume><number>1</number><dates><year>2013</year></dates><isbn>0300-9858</isbn><urls></urls></record></Cite></EndNote>
}}{\fldrslt {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\lang1024\langfe1024\noproof\insrsid11673808 [}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\lang1024\langfe1024\noproof\insrsid5586095 7}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\cf17\lang1024\langfe1024\noproof\insrsid11673808 ]}}}\sectd \ltrsect\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 . }{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 Known tissue sections from EHV-9-infected hamsters were used as positive control samples, and sera from non}{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 -}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 immunized rabbit and goat were used as a negative control. }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\par }\pard \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\outlinelevel0\rin0\lin0\itap0\pararsid7956005 {\rtlch\fcs1 \ai\af0\afs24\alang3073 \ltrch\fcs0 \i\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid396632 
\hich\af0\dbch\af31505\loch\f0 Statistical analysis
\par }\pard \ltrpar\ql \fi720\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid396632 {\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 Two-}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af40\insrsid16591400\charrsid7956005 \hich\af0\dbch\af40\loch\f0 way analysis of variance (ANOVA) test using the GraphPad Prism 5 software were used}{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af40\insrsid12670252 \hich\af0\dbch\af40\loch\f0  }{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 for statistical analysis of changes in cytokines levels}{\rtlch\fcs1 \af62\afs24\alang3073 \ltrch\fcs0 \fs24\cf17\loch\af62\hich\af62\dbch\af31505\insrsid16591400\charrsid7956005 \hich\af62\dbch\af31505\loch\f62 \hich\f62 
 of (IL-2, IL-10, and INF-\'e3}{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid3740742\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 ) genes}{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid12670252 \hich\af0\dbch\af31505\loch\f0  }{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
from brain tissues.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  Comparisons were considered significant at a }{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16591400\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 P value \loch\af0\dbch\af31505\hich\f0 \u8804\'3d\hich\af0\dbch\af31505\loch\f0  0.05.}{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139 
\par }{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid396632 
\par }{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid13698466 
\par }{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid396632 
\par }{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16676770 
\par }{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16676770\charrsid396632 
\par }\pard \ltrpar\ql \qk10\li0\ri0\sa200\sl480\slmult1\widctlpar\wrapdefault\faauto\outlinelevel0\rin0\lin0\itap0\pararsid7956005 {\rtlch\fcs1 \ab\af0\afs24\alang3073 \ltrch\fcs0 \b\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 RESULTS
\par }\pard \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\itap0\pararsid7956005\contextualspace {\rtlch\fcs1 \ai\af0\afs24\alang3073 \ltrch\fcs0 
\i\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 Clinical findings}{\rtlch\fcs1 \ai\af0\afs24\alang3073 \ltrch\fcs0 
\i\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  and death}{\rtlch\fcs1 \ai\af0\afs24\alang3073 \ltrch\fcs0 
\i\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\par }\pard \ltrpar\ql \qk10\fi720\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\itap0\pararsid7956005 {\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 All animals in the EHV-9-inoculated groups}{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid12670252 
\hich\af0\dbch\af31505\loch\f0  }{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 (the }{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid1584216\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 2}{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 \fs24\cf17\super\loch\af0\hich\af0\dbch\af31505\insrsid1584216\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 nd}{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid1584216\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  and3}{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\super\loch\af0\hich\af0\dbch\af31505\insrsid1584216\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 rd}{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid1584216\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0  groups}{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 ) showed }{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid1584216\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 similar clinical}{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0  signs }{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 on the 3}{\rtlch\fcs1 
\af0\afs24\alang3073 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\super\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 rd}{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 dpi}{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
. The early clinical signs included depression, salivation, nasal discharge, lack of coordination, and periodic convulsions, which then developed into lateral recumbency and coma in most of the animals. }{\rtlch\fcs1 \ab\ai\af0\afs24\alang3073 
\ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 There was no dead animal on the 3}{\rtlch\fcs1 \ab\ai\af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\super\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 rd}{\rtlch\fcs1 \ab\ai\af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 dpi, two dead anim\hich\af0\dbch\af31505\loch\f0 als in both groups on the 4}{\rtlch\fcs1 \ab\ai\af0\afs24\alang3073 
\ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\super\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 th}{\rtlch\fcs1 \ab\ai\af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 dpi, and three dead animals on the 5}{\rtlch\fcs1 \ab\ai\af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\super\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 th}{\rtlch\fcs1 \ab\ai\af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 dpiin the second group. In addition, four dead animals were observed on the 5}{\rtlch\fcs1 
\ab\ai\af0\afs24\alang3073 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\super\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 th}{\rtlch\fcs1 \ab\ai\af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 dpi in the third group. No deaths or clinical signs were observed in the non-treated control group. The number
\hich\af0\dbch\af31505\loch\f0  of affected animals remaining on each day of experiment is shown in}{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  Table 2.}{
\rtlch\fcs1 \ab\ai\af0\afs24\alang3073 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\par }\pard \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\tx2760\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\itap0\pararsid7956005 {\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 
\i\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 Changes in bodyweight gain
\par }\pard \ltrpar\ql \qk10\fi600\li0\ri0\sl480\slmult1\widctlpar\tx2760\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\itap0\cufi250\pararsid7956005 {\rtlch\fcs1 \ab\ai\af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
Both the EHV-9-inoculated groups with or without propolis treatment showed a significant reduction in bodyweight gain on the 5}{\rtlch\fcs1 \ab\ai\af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\super\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 th}{\rtlch\fcs1 \ab\ai\af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 dpi compared to the con\hich\af0\dbch\af31505\loch\f0 
trol group, while the control group showed a normal pattern of bodyweight gain.
\par }\pard \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\tx2760\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\itap0\pararsid7956005 {\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 
\i\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 Gross findings\tab }{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 
\i\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\par }\pard \ltrpar\ql \qk10\fi480\li0\ri0\sl480\slmult1\widctlpar\tx2760\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\itap0\cufi200\pararsid7956005 {\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 No specific gross abnormalities were observed in the organs and tissues at necropsy, except congestion of the meningeal and cerebral blood vessels.}{
\rtlch\fcs1 \ab\ai\af0\afs24\alang3073 \ltrch\fcs0 \b\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\par }\pard \ltrpar\ql \qk10\fi-142\li142\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin142\itap0\pararsid7956005 {\rtlch\fcs1 \ai\af0\afs24\alang3073 \ltrch\fcs0 
\i\f0\fs24\cf17\insrsid16601139\charrsid7956005 Histopathological examination
\par }\pard \ltrpar\ql \qk10\fi360\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\cufi150\pararsid7956005 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 In the EHV-9-inoculated groups, t}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 
here were various degree}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 s}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\cf17\insrsid16601139\charrsid7956005  of non}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 -}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\cf17\insrsid16601139\charrsid7956005 suppurative encephalitis characterized by perivascular cuffing, focal or diffuse gliosis, neuronal degeneration and neuronal loss,}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  and frequent eosinophilic int\hich\af0\dbch\af31505\loch\f0 
ranuclear inclusion bodies in the degenerating neuronal cells }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 in infected animals }{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 
(Fig.1}{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 A, 1B, 1C}{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 
\f0\fs24\cf17\insrsid16601139\charrsid7956005 ).}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005  Lesions were predominant in the olfactory bulb and gray matter of the cerebrum}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  in the brains from both theEHV-9-inoculated groups. There was no significant \hich\af0\dbch\af31505\loch\f0 
difference between the second group and third group in the prevalence of neuronal lesions. No lesion}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15551700\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 s}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  w}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15551700\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 ere}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  observed in the brains from the non-treated control group. }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\cf17\insrsid16601139\charrsid7956005 
\par }\pard \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid7956005 {\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\f0\fs24\cf17\insrsid16601139\charrsid7956005 
Viral antigens by immunohistochemistry
\par }\pard \ltrpar\ql \qk10\fi720\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid7956005 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 Viral antigens were detected in 
}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 the }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\cf17\insrsid16601139\charrsid7956005 olfactory bulb from the 3}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\super\insrsid16601139\charrsid7956005 rd}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 dpi}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 
. The amount of viral antigens increased on the 4}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\super\insrsid16601139\charrsid7956005 th}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 dpiin the second group }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 
and was more abundant on the 5}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\super\insrsid16601139\charrsid7956005 th}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 dpiin the third group}{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005  (Fig.1}{
\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 D}{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 
\f0\fs24\cf17\insrsid16601139\charrsid7956005 ).}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005  No positive immunostaining was observed in the olfactory bulb on the 2}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\cf17\super\insrsid16601139\charrsid7956005 nd}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
dpi or in the control group}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 .
\par }\pard \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid7956005 {\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15551700\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 Detection of }{\rtlch\fcs1 \ai\af0\afs24\alang3073 \ltrch\fcs0 \i\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15551700\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 viral DNA and}{
\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid6581916 \hich\af0\dbch\af31505\loch\f0  }{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 Cytokines levels using qRT-PCR 
\par }\pard \ltrpar\ql \qk10\fi360\li110\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin110\itap0\cufi150\culi50\pararsid7956005 {\rtlch\fcs1 \ab\af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15551700\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 Viral DNA was detected in the brain tissue of infected animals from the 2}{\rtlch\fcs1 \ab\af0\afs24\alang3073 
\ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\super\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15551700\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 nd}{\rtlch\fcs1 \ab\af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15551700\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  dpi until the end of the experiment (5}{\rtlch\fcs1 \ab\af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\super\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15551700\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 th}{\rtlch\fcs1 \ab\af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15551700\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  dpi).
\par }\pard \ltrpar\ql \fi470\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid14769283 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid14769283\charrsid13698466 \hich\af0\dbch\af31505\loch\f0 
In this study}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid13698466 \hich\af0\dbch\af31505\loch\f0 , administration of }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid1584216\charrsid13698466 \hich\af0\dbch\af31505\loch\f0 5000 ppm of ethanol extract of Brazilian green propolis by gavage for 7 days resulted}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid13698466 \hich\af0\dbch\af31505\loch\f0  in a }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid1584216\charrsid13698466 \hich\af0\dbch\af31505\loch\f0 
19}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid13698466 -}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid4075048\charrsid13698466 
\hich\af0\dbch\af31505\loch\f0 15,9,}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid13698466 \hich\af0\dbch\af31505\loch\f0 fold increase in }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid1584216\charrsid13698466 \hich\af0\dbch\af31505\loch\f0 mRNA levels of }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af40\insrsid1584216\charrsid13698466 
\hich\af0\dbch\af40\loch\f0 IL-2, IL-10, and IFN-}{\rtlch\fcs1 \af34\afs24 \ltrch\fcs0 \fs24\cf17\loch\af34\hich\af34\dbch\af41\insrsid1584216\charrsid13698466 \loch\af34\dbch\af41\hich\f34 \u-10187\'3f\u-8450\'3f}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid1584216\charrsid13698466 \hich\af0\dbch\af31505\loch\f0  cytokines }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid4075048\charrsid13698466 
\hich\af0\dbch\af31505\loch\f0  respectively }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid1584216\charrsid13698466 \hich\af0\dbch\af31505\loch\f0 in propolis treated hamsters at the }{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid132768\charrsid13698466 \hich\af0\dbch\af31505\loch\f0 7}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\super\loch\af0\hich\af0\dbch\af31505\insrsid1584216\charrsid13698466 
\hich\af0\dbch\af31505\loch\f0 th}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid1584216\charrsid13698466 \hich\af0\dbch\af31505\loch\f0  day from propolis administration in comparison t}{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid4075048\charrsid13698466 \hich\af0\dbch\af31505\loch\f0 o the control non-treated group.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid1584216\charrsid13698466 
\par }\pard \ltrpar\ql \fi470\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid4075048 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid13698466 \hich\af0\dbch\af31505\loch\f0 
There were}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid4075048\charrsid13698466 \hich\af0\dbch\af31505\loch\f0  also a }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid13698466 \hich\af0\dbch\af31505\loch\f0 marked }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid13698466 \hich\af0\dbch\af31505\loch\f0 increasein mRNA levels of }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af40\insrsid16601139\charrsid13698466 
\hich\af0\dbch\af40\loch\f0 IL-2, IL-10, and IFN-}{\rtlch\fcs1 \af34\afs24 \ltrch\fcs0 \fs24\cf17\loch\af34\hich\af34\dbch\af41\insrsid16601139\charrsid13698466 \loch\af34\dbch\af41\hich\f34 \u-10187\'3f\u-8450\'3f}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid13698466 \hich\af0\dbch\af31505\loch\f0 in the }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid13698466 \hich\af0\dbch\af31505\loch\f0 brain tissue }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid13698466 \hich\af0\dbch\af31505\loch\f0 of all EHV-9-infected groups}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid1584216\charrsid13698466 \hich\af0\dbch\af31505\loch\f0  either propolis treated}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid6507303\charrsid13698466 \hich\af0\dbch\af31505\loch\f0  (}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid12670252\charrsid13698466 \hich\af0\dbch\af31505\loch\f0 3}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\super\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid12670252\charrsid13698466 \hich\af0\dbch\af31505\loch\f0 rd}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid12670252\charrsid13698466 \hich\af0\dbch\af31505\loch\f0  group}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid6507303\charrsid13698466 \hich\af0\dbch\af31505\loch\f0 ) (Fig. }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid3933355\charrsid13698466 \hich\af0\dbch\af31505\loch\f0 2}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid10243114 \hich\af0\dbch\af31505\loch\f0 A}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid12670252 
\hich\af0\dbch\af31505\loch\f0 , B, C\hich\af0\dbch\af31505\loch\f0 , D}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid6507303\charrsid13698466 \hich\af0\dbch\af31505\loch\f0 
) or untreated group (2}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\super\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid6507303\charrsid13698466 \hich\af0\dbch\af31505\loch\f0 nd}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid6507303\charrsid13698466 \hich\af0\dbch\af31505\loch\f0  group) (Data under publication)}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid13698466 \hich\af0\dbch\af31505\loch\f0 . No significant differences were observed between the }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid6507303\charrsid13698466 \hich\af0\dbch\af31505\loch\f0 2}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\super\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid6507303\charrsid13698466 \hich\af0\dbch\af31505\loch\f0 nd}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid6507303\charrsid13698466 \hich\af0\dbch\af31505\loch\f0  and the 3}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\super\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid6507303\charrsid13698466 \hich\af0\dbch\af31505\loch\f0 rd}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid6507303\charrsid13698466 \hich\af0\dbch\af31505\loch\f0  groups in cytokines levels.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid13698466 
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid7956005 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf6\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid14884136 
\par 
\par }{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \b\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid14884136\charrsid7956005 
\par }\pard \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid10570670 {\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \b\f0\fs24\cf17\insrsid16601139\charrsid7956005 DISCUSSION}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid10570670 
\par }\pard \ltrpar\ql \qk10\fi720\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16676770 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid16601139\charrsid7956005 
Being a neuropathogenic virus, EHV-9 is replicated in the olfactory mucosal cell}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\insrsid7956005\charrsid7956005 s after intranasal inoculation }{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24\alang3073 
\ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 
 ADDIN EN.CITE <EndNote><Cite><Author>Fukushi</Author><Year>2000</Year><RecNum>18</RecNum><DisplayText>(10, 17)</DisplayText><record><rec-number>18</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0r
\hich\af0\dbch\af31505\loch\f0 
x9sp92" timestamp="0">18</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Fukushi, Hideto</author><author>Taniguchi, Akiko</author><author>Yasuda, Keiko</author><author>Yanai, Tokuma</author><author>Masegi, 
\hich\af0\dbch\af31505\loch\f0 T\hich\af0\dbch\af31505\loch\f0 
oshiaki</author><author>Yamaguchi, Tsuyoshi</author><author>Hirai, Katsuya</author></authors></contributors><titles><title>A hamster model of equine herpesvirus 9 induced encephalitis</title><secondary-title>Journal of neurovirology</secondary-title></tit
\hich\af0\dbch\af31505\loch\f0 l\hich\af0\dbch\af31505\loch\f0 
es><pages>314-319</pages><volume>6</volume><number>4</number><dates><year>2000</year></dates><isbn>1355-0284</isbn><urls></urls></record></Cite><Cite><Author>Narita</Author><Year>2001</Year><RecNum>19</RecNum><record><rec-number>19</rec-number><foreign-ke
\hich\af0\dbch\af31505\loch\f0 y\hich\af0\dbch\af31505\loch\f0 
s><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="0">19</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Narita, M</author><author>Uchimura, A</author><author>Kawanabe, M</author><autho
\hich\af0\dbch\af31505\loch\f0 r\hich\af0\dbch\af31505\loch\f0 
>Fukushi, H</author><author>Hirai, K</author></authors></contributors><titles><title>Invasion and spread of equine herpesvirus 9 in the olfactory pathway of pigs after intranasal inoculation</title><secondary-title>Journal of comparative pathology</second
\hich\af0\dbch\af31505\loch\f0 a\hich\af0\dbch\af31505\loch\f0 ry-title></titles><pages>265-272</pages><volume>124</volume><number>4</number><dates><year>2001</year></dates><isbn>0021-9975</isbn><urls></urls></record></Cite></EndNote>}}{\fldrslt {
\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 [}{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 10, 17}{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 ]}}}\sectd \ltrsect\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj {\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 .}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 The time course of infection from the nasal cavity to the brain, and the \hich\af0\dbch\af31505\loch\f0 
characteristics of the brain lesions were similar to that observed in previous studies using a hamster model of EHV-9-induced encephalitis }{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16676770 \hich\af0\dbch\af31505\loch\f0  ADDIN EN.CITE <EndNote><Cite><Author>Fukushi</Author><Year>2000</Year><RecNum>18</RecNum><DisplayText>(10, 17)</Disp
\hich\af0\dbch\af31505\loch\f0 
layText><record><rec-number>18</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="0">18</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Fukushi, Hideto</author><
\hich\af0\dbch\af31505\loch\f0 a\hich\af0\dbch\af31505\loch\f0 
uthor>Taniguchi, Akiko</author><author>Yasuda, Keiko</author><author>Yanai, Tokuma</author><author>Masegi, Toshiaki</author><author>Yamaguchi, Tsuyoshi</author><author>Hirai, Katsuya</author></authors></contributors><titles><title>A hamster model of equin
\hich\af0\dbch\af31505\loch\f0 e\hich\af0\dbch\af31505\loch\f0 
 herpesvirus 9 induced encephalitis</title><secondary-title>Journal of neurovirology</secondary-title></titles><pages>314-319</pages><volume>6</volume><number>4</number><dates><year>2000</year></dates><isbn>1355-0284</isbn><urls></urls></record></Cite><Ci
\hich\af0\dbch\af31505\loch\f0 t\hich\af0\dbch\af31505\loch\f0 
e><Author>Narita</Author><Year>2001</Year><RecNum>19</RecNum><record><rec-number>19</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="0">19</key></foreign-keys><ref-type name="Journal Article">17</ref-type><co
\hich\af0\dbch\af31505\loch\f0 n\hich\af0\dbch\af31505\loch\f0 
tributors><authors><author>Narita, M</author><author>Uchimura, A</author><author>Kawanabe, M</author><author>Fukushi, H</author><author>Hirai, K</author></authors></contributors><titles><title>Invasion and spread of equine herpesvirus 9 in the olfactory p
\hich\af0\dbch\af31505\loch\f0 a\hich\af0\dbch\af31505\loch\f0 
thway of pigs after intranasal inoculation</title><secondary-title>Journal of comparative pathology</secondary-title></titles><pages>265-272</pages><volume>124</volume><number>4</number><dates><year>2001</year></dates><isbn>0021-9975</isbn><urls></urls></
\hich\af0\dbch\af31505\loch\f0 r\hich\af0\dbch\af31505\loch\f0 ecord></Cite></EndNote>}}{\fldrslt {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\langfenp1041\insrsid11673808 
\hich\af0\dbch\af31505\loch\f0 [}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\langfenp1041\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 10, 17}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\langfenp1041\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 ]}}}\sectd \ltrsect\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj {\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16676770 .}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 Several studies }{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 
\i\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 in vitro }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 have shown the effect of propolis on the RNA and DNA of different viruses, including herpes simplex type 1, herpes simplex type 2, adenovirus type 2, po\hich\af0\dbch\af31505\loch\f0 
liovirus type 2, vesicular stomatitis virus }{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid328807 \hich\af0\dbch\af31505\loch\f0 
 ADDIN EN.CITE <EndNote><Cite><Author>Amoros</Author><Year>1992</Year><RecNum>7</RecNum><DisplayText>(1)</DisplayText><record><rec-number>7</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0\hich\af0\dbch\af31505\loch\f0 
wxf0rx9sp92" timestamp="0">7</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Amoros, M</author><author>Sauvager, F</author><author>Girre, L</author><author>Cormier, M</author></authors></contributors><title
\hich\af0\dbch\af31505\loch\f0 s\hich\af0\dbch\af31505\loch\f0 
><title>In vitro antiviral activity of propolis</title><secondary-title>Apidologie</secondary-title></titles><pages>231-240</pages><volume>23</volume><number>3</number><dates><year>1992</year></dates><isbn>0044-8435</isbn><urls></urls></record></Cite></En
\hich\af0\dbch\af31505\loch\f0 d\hich\af0\dbch\af31505\loch\f0 Note>}}{\fldrslt {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 [}{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid328807 \hich\af0\dbch\af31505\loch\f0 1}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 ]}}}\sectd \ltrsect\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj {\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 ,vaccinia virus, and the virus responsible for Newcastle disease }{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16676770 \hich\af0\dbch\af31505\loch\f0  ADDIN EN.CITE <EndNote><Cite><Author>Maksimova-Todorova V</Author><Year>1985</Year><RecNum>8</RecNum><DisplayText>(14)</DisplayText><record><re
\hich\af0\dbch\af31505\loch\f0 
c-number>8</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="0">8</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Maksimova-Todorova V,Manolova N, Gegova G, Ser
\hich\af0\dbch\af31505\loch\f0 k\hich\af0\dbch\af31505\loch\f0 
edzhieva Y, Uzunov S, Pancheva S, Marekov N, Bankova V. </author></authors></contributors><titles><title> Antiviral effects of some fractions isolated from propolis. </title><secondary-title>ActaMicrobiolog. Bulgarica </secondary-title></titles><volume>17
\hich\af0\dbch\af31505\loch\f0 :\hich\af0\dbch\af31505\loch\f0 79\hich\f0 \endash \loch\f0 85.</volume><dates><year>1985</year></dates><urls></urls></record></Cite></EndNote>}}{\fldrslt {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 [}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid16676770 
\hich\af0\dbch\af31505\loch\f0 14}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 ]}}}\sectd \ltrsect
\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
. Flavonoids such as quercetin and rutin, which are found in honey and propolis}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid12670252 \hich\af0\dbch\af31505\loch\f0  }{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16676770 \hich\af0\dbch\af31505\loch\f0  ADDIN EN.CITE <EndNote><Cite><Author>Yao</Author><Year>2004</Year><RecNum>20</RecN\hich\af0\dbch\af31505\loch\f0 
um><DisplayText>(20, 33)</DisplayText><record><rec-number>20</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="0">20</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><au
\hich\af0\dbch\af31505\loch\f0 t\hich\af0\dbch\af31505\loch\f0 
hor>Yao, Lihu</author><author>Jiang, Yueming</author><author>D&apos;Arcy, Bruce</author><author>Singanusong, Riantong</author><author>Datta, Nivedita</author><author>Caffin, Nola</author><author>Raymont, Katherine</author></authors></contributors><titles>
\hich\af0\dbch\af31505\loch\f0 <\hich\af0\dbch\af31505\loch\f0 
title>Quantitative high-performance liquid chromatography analyses of flavonoids in Australian Eucalyptus honeys</title><secondary-title>Journal of Agricultural and Food Chemistry</secondary-title></titles><pages>210-214</pages><volume>52</volume><number>
\hich\af0\dbch\af31505\loch\f0 2}{\rtlch\fcs1 \af59\afs24 \ltrch\fcs0 \fs24\cf17\loch\af59\hich\af59\dbch\af31505\insrsid16676770 \hich\af59\dbch\af31505\loch\f59 \hich\f59 
</number><dates><year>2004</year></dates><isbn>0021-8561</isbn><urls></urls></record></Cite><Cite><Author>Or\'9a\loch\f59 \hich\f59 oli\'e6\loch\f59 
</Author><Year>2005</Year><RecNum>21</RecNum><record><rec-number>21</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wx\hich\af59\dbch\af31505\loch\f59 f\hich\af59\dbch\af31505\loch\f59 \hich\f59 
0rx9sp92" timestamp="0">21</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Or\'9a\loch\f59 \hich\f59 oli\'e6\loch\f59 \hich\f59 , Nada</author><author>Ba\'9a\loch\f59 \hich\f59 i\'e6\loch\f59 
, Ivan</author></authors></contributors><titles><title>Water-soluble derivative of propolis and \hich\af59\dbch\af31505\loch\f59 i}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16676770 
\hich\af0\dbch\af31505\loch\f0 
ts polyphenolic compounds enhance tumoricidal activity of macrophages</title><secondary-title>Journal of ethnopharmacology</secondary-title></titles><pages>37-45</pages><volume>102</volume><number>1</number><dates><year>2005</year></dates><isbn>0378-8741<
\hich\af0\dbch\af31505\loch\f0 /\hich\af0\dbch\af31505\loch\f0 isbn><urls></urls></record></Cite></EndNote>}}{\fldrslt {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 
\hich\af0\dbch\af31505\loch\f0 [}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 20, 33}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 ]}}}\sectd \ltrsect\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj {\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 , }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 were thought to have }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 antiviral activity against HSV, poliovirus, and Sindbis virus }{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16676770 \hich\af0\dbch\af31505\loch\f0  ADDIN EN.CITE <EndNote><Cite><Author>Cody</Author><Year>1986</Year><RecNum>22</RecNum><DisplayText>(4, 1\hich\af0\dbch\af31505\loch\f0 
6)</DisplayText><record><rec-number>22</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="0">22</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cody, Vivian</aut
\hich\af0\dbch\af31505\loch\f0 h\hich\af0\dbch\af31505\loch\f0 
or><author>Middleton, Elliott</author><author>Harborne, Jeffrey B</author></authors></contributors><titles><title>Plant flavonoids in biology and medicine: biochemical, pharmacological, and structure-activity relationships: proceedings of a symposium held
\hich\af0\dbch\af31505\loch\f0  \hich\af0\dbch\af31505\loch\f0 
in Buffalo, New York, July 22-26, 1985</title><secondary-title>Progress in clinical and biological research (USA)</secondary-title></titles><dates><year>1986</year></dates><isbn>0845150634</isbn><urls></urls></record></Cite><Cite><Author>Middleton</Author
\hich\af0\dbch\af31505\loch\f0 >\hich\af0\dbch\af31505\loch\f0 
<Year>1994</Year><RecNum>23</RecNum><record><rec-number>23</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="0">23</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><auth
\hich\af0\dbch\af31505\loch\f0 o\hich\af0\dbch\af31505\loch\f0 
r>Middleton, E</author></authors></contributors><titles><title>The impact of plant flavonoids on mammalian biology: implications for immunity, inflammation and cancer</title><secondary-title>The flavonoids, advances in research since 1986</secondary-title
\hich\af0\dbch\af31505\loch\f0 >\hich\af0\dbch\af31505\loch\f0 </titles><pages>619-645</pages><dates><year>1994</year></dates><urls></urls></record></Cite></EndNote>}}{\fldrslt {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 [}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid16676770 
\hich\af0\dbch\af31505\loch\f0 4, 16}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 ]}}}\sectd \ltrsect
\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 . In addition}{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 , }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 two flavonoids (chrysin and campherol) have been proven to have a very active role in the inhibition of replication of several he
\hich\af0\dbch\af31505\loch\f0 rpes viruses, adenovirus, and rotavirus }{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid328807 \hich\af0\dbch\af31505\loch\f0 
 ADDIN EN.CITE <EndNote><Cite><Author>Chen PC</Author><Year>1996</Year><RecNum>24</RecNum><DisplayText>(3)</DisplayText><record><rec-number>24</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0w\hich\af0\dbch\af31505\loch\f0 
xf0rx9sp92" timestamp="0">24</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Chen PC,Wong G. </author></authors></contributors><titles><title>Honey bee propolis: prospects in medicine. </title><secondary-ti
\hich\af0\dbch\af31505\loch\f0 t\hich\af0\dbch\af31505\loch\f0 le>BeeWorld 77:8\hich\f0 \endash \loch\f0 15</secondary-title></titles><dates><year>1996</year></dates><urls></urls></record></Cite></EndNote>}}{\fldrslt {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 [}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid328807 
\hich\af0\dbch\af31505\loch\f0 3}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 ]}}}\sectd \ltrsect
\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 . }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid6507303\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 However}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 , p}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 ropolis and its derivatives have }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
been reported to possess }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
the ability to inhibit virus propagation via reduction of viral multiplication and virucidal action}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 . In the present study, no obvious effects in preventing }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 EHV-9-}{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 induced acute encephalitis were observed after administration of propolis. }{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid797031\charrsid7956005 
\par }\pard \ltrpar\ql \fi720\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid11673808 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 A previous study r\hich\af0\dbch\af31505\loch\f0 eported}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid3933355 \hich\af0\dbch\af31505\loch\f0  that, }{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 propolis}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 as }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 a potential immune-enhancing }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 agent via }{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 activ}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 ation of }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 cellular and humoral immunity, }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 as well as a possible }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 natural antibiotic with no side effects [9]. In this }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 study}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 , the concentrations of IL-2, IL-10 and IFN-}{\rtlch\fcs1 \af34\afs24 \ltrch\fcs0 \fs24\cf17\loch\af34\hich\af34\dbch\af41\insrsid16601139\charrsid7956005 \loch\af34\dbch\af41\hich\f34 \u-10187\'3f\u-8450\'3f}{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  in the brain tissue \hich\af0\dbch\af31505\loch\f0 were determined by }{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 
\f0\fs24\cf17\insrsid16601139\charrsid7956005 qRT-PCR }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 and}{\mmath{\*\moMath {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af402\hich\af402\dbch\af31505\insrsid16601139 \loch\af402\dbch\af31505\hich\f402 {\mr\mscr0\msty0 \'c4\'c4\loch\f402 Ct m}}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af34\hich\af34\dbch\af31505\insrsid16601139 
\hich\af34\dbch\af31505\loch\f34 {\mr\mscr0\msty0 ethod}}}{\mmathPict{\*\shppict{\pict{\*\picprop\shplid1025{\sp{\sn shapeType}{\sv 75}}{\sp{\sn fFlipH}{\sv 0}}{\sp{\sn fFlipV}{\sv 0}}{\sp{\sn pictureTransparent}{\sv 16777215}}
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\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 . }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid10440022\charrsid7956005 There }{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \f0\fs24\insrsid5332575\charrsid7956005 were considerable increases}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid10440022\charrsid7956005  in the mRNAs for the Th-1 cytokines, IL-2 and }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid10440022\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 IFN-}{\rtlch\fcs1 \af34\afs24 \ltrch\fcs0 \fs24\cf17\loch\af34\hich\af34\dbch\af41\insrsid10440022\charrsid7956005 \loch\af34\dbch\af41\hich\f34 
\u-10187\'3f\u-8450\'3f}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af41\insrsid14895994\charrsid7956005 \hich\af0\dbch\af41\loch\f0  and}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid10440022\charrsid7956005  Th2}{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af41\insrsid10440022\charrsid7956005 \hich\af0\dbch\af41\loch\f0  cytokines (IL-10}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af41\insrsid11673808 
\hich\af0\dbch\af41\loch\f0 )}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af41\insrsid12670252 \hich\af0\dbch\af41\loch\f0  }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 in propolis-treated group}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid797031\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0  before viral challenge}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid12670252 \hich\af0\dbch\af31505\loch\f0  }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid5332575\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 in}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid14895994\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
 comparison to }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 those }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid14895994\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 of}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
 the control group}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid13376299\charrsid7956005 . }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
IL-2, a cytokine secreted by type 1 helper T cells (Th1 cells), mediates cellular immunity. In addition, IL-2 can }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid9923455\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
stimulate }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 the production of immunoglobulins and }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid9923455\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 promote }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
the proliferation and differentiation of natural }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid9923455\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 killer cells }{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16676770 \hich\af0\dbch\af31505\loch\f0  ADDIN EN.CITE <EndNote>\hich\af0\dbch\af31505\loch\f0 
<Cite><Author>Nhiem</Author><Year>2010</Year><RecNum>25</RecNum><DisplayText>(18)</DisplayText><record><rec-number>25</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="0">25</key></foreign-keys><ref-type name=
\hich\af0\dbch\af31505\loch\f0 "\hich\af0\dbch\af31505\loch\f0 
Journal Article">17</ref-type><contributors><authors><author>Nhiem, Nguyen Xuan</author><author>Van Kiem, Phan</author><author>Van Minh, Chau</author><author>Tai, Bui Huu</author><author>Tung, Nguyen Huu</author><author>Soung, Kwang Su</author><author>Kim
,\hich\af0\dbch\af31505\loch\f0  Jun Ho</author><author>Ahn, Ji Young</author><author>Lee, Young-Mi</author><author>Kim, Young Ho</author></authors></contributors><titles><title>Structure\hich\f0 \endash \loch\f0 
activity relationship of lupane-triterpene glycosides from Acanthopanax koreanum on spleen lymphocy\hich\af0\dbch\af31505\loch\f0 t}{\rtlch\fcs1 \af62\afs24 \ltrch\fcs0 \fs24\cf17\loch\af62\hich\af62\dbch\af31505\insrsid16676770 
\hich\af62\dbch\af31505\loch\f62 \hich\f62 e IL-2 and IFN-\'e3\loch\f62 
</title><secondary-title>Bioorganic &amp; medicinal chemistry letters</secondary-title></titles><pages>4927-4931</pages><volume>20</volume><number>16</number><dates><year>2010</year></dates><isbn>0960-894X</isbn><urls></urls></record></Cit
\hich\af62\dbch\af31505\loch\f62 e}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 ></EndNote>}}{\fldrslt {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 [}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid16676770 
\hich\af0\dbch\af31505\loch\f0 18}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 ]}}}\sectd \ltrsect
\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 .}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid14895994\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 IFN-}{\rtlch\fcs1 \af34\afs24 \ltrch\fcs0 \fs24\cf17\loch\af34\hich\af34\dbch\af41\insrsid14895994\charrsid7956005 \loch\af34\dbch\af41\hich\f34 
\u-10187\'3f\u-8450\'3f}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid14895994\charrsid7956005 \hich\af0\dbch\af31505\loch\f0   is }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid14895994\charrsid7956005 
responsible for activation  of macrophage, killing of many of  intracellular pathogens and}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid5332575\charrsid7956005  control of }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\insrsid14895994\charrsid7956005 infection }{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid16676770  ADDIN EN.CITE <EndNote><Cite><Author>Heinzel</Author><Year>
1989</Year><RecNum>30</RecNum><DisplayText>(13, 27)</DisplayText><record><rec-number>30</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="1520612318">30</key></foreign-keys><ref-type name="Journal Article">17<
/
ref-type><contributors><authors><author>Heinzel, Frederick P</author><author>Sadick, Michael D</author><author>Holaday, Bettie J</author><author>Coffman, RL</author><author>Locksley, Richard M</author></authors></contributors><titles><title>Reciprocal exp
r
ession of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets</title><secondary-title>Journal of Experimental Medicine</secondary-title></titles><periodic
a
l><full-title>Journal of Experimental Medicine</full-title></periodical><pages>59-72</pages><volume>169</volume><number>1</number><dates><year>1989</year></dates><isbn>0022-1007</isbn><urls></urls></record></Cite><Cite><Author>Squires</Author><Year>1989</
Y
ear><RecNum>31</RecNum><record><rec-number>31</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="1520612412">31</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>S
q
uires, KE</author><author>Schreiber, RD</author><author>McElrath, MJ</author><author>Rubin, BY</author><author>Anderson, SL</author><author>Murray, HW</author></authors></contributors><titles><title>Experimental visceral leishmaniasis: role of endogenous 
I
FN-gamma in host defense and tissue granulomatous response</title><secondary-title>The Journal of Immunology</secondary-title></titles><periodical><full-title>The Journal of Immunology</full-title></periodical><pages>4244-4249</pages><volume>143</volume><
number>12</number><dates><year>1989</year></dates><isbn>0022-1767</isbn><urls></urls></record></Cite></EndNote>}}{\fldrslt {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\lang1024\langfe1024\noproof\insrsid11673808 [}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\lang1024\langfe1024\noproof\insrsid16676770 13, 27}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\lang1024\langfe1024\noproof\insrsid11673808 ]}}}\sectd \ltrsect\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj 
{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid5332575\charrsid7956005 .}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid5332575\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  IFN-}{\rtlch\fcs1 \af34\afs24 
\ltrch\fcs0 \fs24\cf17\loch\af34\hich\af34\dbch\af41\insrsid5332575\charrsid7956005 \loch\af34\dbch\af41\hich\f34 \u-10187\'3f\u-8450\'3f}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid5332575\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 is secreted by type 1 helper T cells (Th1 cells), and it can reflect the basic status of cellular and humoral immunity of an or\hich\af0\dbch\af31505\loch\f0 ganism to a certain extent}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid11494297\charrsid7956005 .}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid14895994\charrsid7956005 
\par }\pard \ltrpar\ql \fi720\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid16676770 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
The levels of cytokine secretion reflect the state of cellular and humoral immunity in an organism. Both cellular and humoral immunity play important roles in defense against infectious disease in the host }{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16676770 \hich\af0\dbch\af31505\loch\f0  ADDIN EN.CITE <EndNot\hich\af0\dbch\af31505\loch\f0 
e><Cite><Author>Fischer</Author><Year>2007</Year><RecNum>26</RecNum><DisplayText>(9)</DisplayText><record><rec-number>26</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="0">26</key></foreign-keys><ref-type na
\hich\af0\dbch\af31505\loch\f0 m\hich\af0\dbch\af31505\loch\f0 \hich\f0 e="Journal Article">17</ref-type><contributors><authors><author>Fischer, Geferson</author><author>Concei\'e7\'e3\loch\f0 \hich\f0 o, Fabricio Rochedo</author><author>Leite, F\'e1
\loch\f0 bio Pereira Leivas</author><author>Dummer, Luana Alves</author><author>Vargas, Gilberto D\hich\f0 \rquote \loch\f0 Avila</author>\hich\af0\dbch\af31505\loch\f0 <\hich\af0\dbch\af31505\loch\f0 \hich\f0 author>de Oliveira H\'fc\loch\f0 \hich\f0 
bner, S\'ed\loch\f0 \hich\f0 lvia</author><author>Dellagostin, Odir Ant\'f4\loch\f0 \hich\f0 nio</author><author>Paulino, Niraldo</author><author>Paulino, Amar\'ed\loch\f0 
lis Scremin</author><author>Vidor, Telmo</author></authors></contributors><titles><title>Immunomodulation produced b\hich\af0\dbch\af31505\loch\f0 y\hich\af0\dbch\af31505\loch\f0 
 a green propolis extract on humoral and cellular responses of mice immunized with SuHV-1</title><secondary-title>Vaccine</secondary-title></titles><pages>1250-1256</pages><volume>25</volume><number>7</number><dates><year>2007</year></dates><isbn>0264-410
\hich\af0\dbch\af31505\loch\f0 X\hich\af0\dbch\af31505\loch\f0 </isbn><urls></urls></record></Cite></EndNote>}}{\fldrslt {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 
\hich\af0\dbch\af31505\loch\f0 [}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 9}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 ]}}}\sectd \ltrsect\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj {\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 .}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid11494297\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
 However, this immune enhancement induced by propolis, encephalitis due to EHV-9 occurred as this virus enters the brain via the olfactory nerve, spreads trans-synaptically to connecting neurons along \hich\af0\dbch\af31505\loch\f0 
the olfactory tract, and replicates in the neurons of the olfactory bulbs and cerebrum }{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 
 ADDIN EN.CITE <EndNote><Cite><Author>Fukushi</Author><Year>2000</Year><RecNum>18</RecNum><DisplayText>(10, 17)</DisplayText><record><rec-number>18</rec-number><foreign-\hich\af0\dbch\af31505\loch\f0 
keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="0">18</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Fukushi, Hideto</author><author>Taniguchi, Akiko</author><author>Yasuda, Keik
\hich\af0\dbch\af31505\loch\f0 o\hich\af0\dbch\af31505\loch\f0 
</author><author>Yanai, Tokuma</author><author>Masegi, Toshiaki</author><author>Yamaguchi, Tsuyoshi</author><author>Hirai, Katsuya</author></authors></contributors><titles><title>A hamster model of equine herpesvirus 9 induced encephalitis</title><seconda
\hich\af0\dbch\af31505\loch\f0 r\hich\af0\dbch\af31505\loch\f0 
y-title>Journal of neurovirology</secondary-title></titles><pages>314-319</pages><volume>6</volume><number>4</number><dates><year>2000</year></dates><isbn>1355-0284</isbn><urls></urls></record></Cite><Cite><Author>Narita</Author><Year>2001</Year><RecNum>1
\hich\af0\dbch\af31505\loch\f0 9\hich\af0\dbch\af31505\loch\f0 
</RecNum><record><rec-number>19</rec-number><foreign-keys><key app="EN" db-id="2e990se5f0pp5meevs6xxv0e0wxf0rx9sp92" timestamp="0">19</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Narita, M</author><autho
\hich\af0\dbch\af31505\loch\f0 r\hich\af0\dbch\af31505\loch\f0 
>Uchimura, A</author><author>Kawanabe, M</author><author>Fukushi, H</author><author>Hirai, K</author></authors></contributors><titles><title>Invasion and spread of equine herpesvirus 9 in the olfactory pathway of pigs after intranasal inoculation</title><
\hich\af0\dbch\af31505\loch\f0 s\hich\af0\dbch\af31505\loch\f0 
econdary-title>Journal of comparative pathology</secondary-title></titles><pages>265-272</pages><volume>124</volume><number>4</number><dates><year>2001</year></dates><isbn>0021-9975</isbn><urls></urls></record></Cite></EndNote>}}{\fldrslt {\rtlch\fcs1 
\af0\afs24\alang3073 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 [}{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid16676770 \hich\af0\dbch\af31505\loch\f0 10, 17}{\rtlch\fcs1 \af0\afs24\alang3073 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\noproof\insrsid11673808 \hich\af0\dbch\af31505\loch\f0 ]}}}\sectd \ltrsect\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj {\rtlch\fcs1 
\af0\afs24\alang3073 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid11494297\charrsid7956005 .}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid7956005\charrsid7956005 
\par }\pard \ltrpar\ql \fi720\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid13698466 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid797031\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 In }{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid797031\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
the hamster model of herpesvirus infection used in the present study, the time course of encephalitis from nasal inoculation of EHV-9 to fulminant encephalitis was rather short. Therefore, there might not have been enough time for }{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid7956005\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 progressive}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid12670252 \hich\af0\dbch\af31505\loch\f0  }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid797031\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 enhance}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid797031\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 ment o\hich\af0\dbch\af31505\loch\f0 f }{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid797031\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 immune system}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid797031\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  to protect against EHV-9-induced }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16450172\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 fulminate}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid797031\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  encephalitis }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid797031\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 or at least to decrease the severity of infection }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid797031\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 after propolis}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid12670252 \hich\af0\dbch\af31505\loch\f0  }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid797031\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 administration}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid797031\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
. Pre-treatment with propolis did not prevent EHV-9-induced acute rhinitis and virus replication in the n\hich\af0\dbch\af31505\loch\f0 asal cavity, and eventually, the virus gained access to the olfactory bulb and cerebrum in hamsters.}{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid7956800 \hich\af0\dbch\af31505\loch\f0  The present regime and duration }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid13698466 \hich\af0\dbch\af31505\loch\f0 of}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid12670252 
\hich\af0\dbch\af31505\loch\f0  }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid13698466\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 propolis}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid7956800\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  administered in this study was inadequate for preventing virus replication}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid12670252 \hich\af0\dbch\af31505\loch\f0  }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid1256178 
\hich\af0\dbch\af31505\loch\f0 or}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid12670252 \hich\af0\dbch\af31505\loch\f0  }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid1256178 \hich\af0\dbch\af31505\loch\f0 viral induced}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid1256178\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  encephalitis}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid1256178 \hich\af0\dbch\af31505\loch\f0  or both}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid7956800 \hich\af0\dbch\af31505\loch\f0 , }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid13698466 
\hich\af0\dbch\af31505\loch\f0 however }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid13698466\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 its}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid7956800\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  ability to enhance immunity}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid1256178 \hich\af0\dbch\af31505\loch\f0 . Further studies with prolonged course of treatment and }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16450172 \hich\af0\dbch\af31505\loch\f0 larger doses are in progress}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid797031\charrsid7956005 .}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15220703\charrsid13698466 

\par }\pard \ltrpar\ql \qk10\fi720\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid3175524 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 T}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 he present study}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  showed }{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 that propolis could }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 not necessarily prevent acute encephalitis induced by neuropathogenic EHV-9 by }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 improv}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 ing }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 cellular and humoral immunity.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  This may be due to the quick transmission of virus }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 directly through the olfactory nerve to the brain}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0  before acquisition of }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\loch\af0\hich\af0\dbch\af31505\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 protective im\hich\af0\dbch\af31505\loch\f0 munity.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 \hich\af0\dbch\af31505\loch\f0 
 Further study is needed to determine the potential of propolis in preventing EHV-9 in chronic transmission experiments or by using other routes of infection, such as oral or ocular routes. 
\par }\pard \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid7956005 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \b\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 ACKNOWLEDGEMENTS
\par }\pard \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid12670252 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid16601139\charrsid7956005 
\hich\af0\dbch\af31505\loch\f0 We would like to thank the Nagaragawa Res\hich\af0\dbch\af31505\loch\f0 earch Center, API (Gifu, Japan) for providing valuable advice and for the supply of propolis.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid8918564\charrsid7956005 
\par }\pard \ltrpar\ql \qk10\fi-422\li422\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin422\itap0\cufi-150\pararsid4619795 {\rtlch\fcs1 \ab\af0\afs28\alang3073 \ltrch\fcs0 
\b\f0\fs28\cf17\lang1033\langfe1041\langfenp1041\insrsid4619795\charrsid3933355 REFRENCES}{\ltrch\fcs1 \ab\af0\afs28\alang1033 \rtlch\fcs0 \b\f0\fs28\cf17\lang3073\langfenp1041\insrsid4619795\charrsid3933355 
\par }\pard\plain \ltrpar\s17\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid12089427 \rtlch\fcs1 \af37\afs22\alang1025 \ltrch\fcs0 \f37\fs22\lang1024\langfe1024\cgrid\noproof\langnp1033\langfenp1033 
{\field{\*\fldinst {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\lang1024\langfe1024\langfenp1041\insrsid4619795\charrsid5443932  ADDIN EN.REFLIST }}{\fldrslt {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid15824599\charrsid5443932 1.\tab }{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\lang1024\langfe1024\langfenp1041\insrsid15098061\charrsid5443932 Amoros, M.,Sauvager, F.,Girre, L. and Cormier, M. 1992. In vitro antiviral activity of propolis. Apidologie.}{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \b\f0\fs24\cf17\lang1024\langfe1024\langfenp1041\insrsid15098061\charrsid5443932 23}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\lang1024\langfe1024\langfenp1041\insrsid15098061\charrsid5443932 : 231\endash 240.}{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \f0\fs24\insrsid15824599\charrsid5443932 
\par 2.\tab }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\lang1024\langfe1024\langfenp1041\insrsid15098061\charrsid5443932 Bonveh\'ed
, J. S. and Bermejo F. O. 2013. Element content of propolis collected from different areas of South Spain. Environ Monit Assess. }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \b\f0\fs24\cf17\lang1024\langfe1024\langfenp1041\insrsid15098061\charrsid5443932 185}{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\lang1024\langfe1024\langfenp1041\insrsid15098061\charrsid5443932 : 6035\endash 6047.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\lang1024\langfe1024\langfenp1041\insrsid15824599\charrsid5443932 

\par }\pard\plain \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid12089427 \rtlch\fcs1 \af1\afs22\alang1025 \ltrch\fcs0 \f31506\fs22\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \f0\fs24\lang1024\langfe1024\noproof\insrsid15824599\charrsid5443932 3.\tab }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 
\hich\af0\dbch\af31505\loch\f0 Chen, P. C. andWong, G. 1996. Honey bee propolis: prospects in medicine. BeeWorld.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\b\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 77}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 : 8\hich\f0 \endash \loch\f0 15.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15824599\charrsid5443932 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\lang1024\langfe1024\noproof\insrsid15824599\charrsid5443932 4.\tab }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 Cody, \hich\af0\dbch\af31505\loch\f0 
V.,Middleton, E. andHarborne, J. B. Plant flavonoids in biology and medicine: biochemical, pharmacological, and structure-activity relationships: proceedings of a symposium held in Buffalo, New York, July 22-26, 1985. Progress in Clinical and Biological R
\hich\af0\dbch\af31505\loch\f0 e\hich\af0\dbch\af31505\loch\f0 search (USA).
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\lang1024\langfe1024\noproof\insrsid15824599\charrsid5443932 5.\tab }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 
Duran, N.,Muz, M., Culha, G.,Duran, G. andOzer, B. 2011. GC-MS analysis and antileishmanial activities of two Turkish propolis types.Parasitol Res. }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\b\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 108}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 :95\hich\f0 \endash \loch\f0 105.
\par }\pard\plain \ltrpar\s17\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid12089427 \rtlch\fcs1 \af37\afs22\alang1025 \ltrch\fcs0 \f37\fs22\lang1024\langfe1024\cgrid\noproof\langnp1033\langfenp1033 
{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid15824599\charrsid5443932 6.\tab El-Habashi, N., El-Nahass, E.S., Namihira, Y., Hagiwara, H., Fukushi, H., Narita, M., Hirata, A., Sakai, H. and Yanai, T.  }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\insrsid12089427\charrsid5443932 2011.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid15824599\charrsid5443932 Neuropathogenicity of equine herpesvirus 9 in cattle. J. Equine Vet. Sci}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\insrsid12089427\charrsid5443932 .}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid15824599\charrsid5443932  31: 72-77. 
\par }\pard\plain \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid12089427 \rtlch\fcs1 \af1\afs22\alang1025 \ltrch\fcs0 \f31506\fs22\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\lang1024\langfe1024\noproof\insrsid15824599\charrsid5443932 7.\tab }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid12089427\charrsid5443932 \hich\af0\dbch\af42\loch\f0 
El-Habashi, N., Kato, Y., El-Nahass, E., Fukushi, H., Hirata, A., Sakai, H., Kimura, J. and Yanai, T. 2013. An ocul\hich\af0\dbch\af42\loch\f0 
ar infection model using suckling hamsters inoculated with equine herpesvirus 9 (EHV-9): kinetics of the virus and time-course pathogenesis of EHV-9-induced encephalitis via the eyes. Vet. Pathol.}{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 
\b\fs24\loch\af0\hich\af0\dbch\af42\insrsid12089427\charrsid5443932 \hich\af0\dbch\af42\loch\f0 50}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid12089427\charrsid5443932 \hich\af0\dbch\af42\loch\f0 : 56\hich\f0 \endash 
\loch\f0 64.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid15824599\charrsid5443932 
\par }\pard\plain \ltrpar\s17\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid5443932 \rtlch\fcs1 \af37\afs22\alang1025 \ltrch\fcs0 \f37\fs22\lang1024\langfe1024\cgrid\noproof\langnp1033\langfenp1033 {
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid15824599\charrsid5443932 8.\tab }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid15098061\charrsid5443932 Escobedo, G., Palacios-Arreola, M. I., Olivos, A., L\'f3
pez-Griego, L. and Morales-Montor, J. 2012}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid5443932\charrsid5443932 .}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid15098061\charrsid5443932 
 Tamoxifen treatment in hamsters induces protection during taeniosis by Taenia solium. BioMed. res. inter. }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af40\insrsid5443932\charrsid5443932 \hich\af0\dbch\af40\loch\f0 
http://dx.doi.org/10.1155/2013/280496.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid15098061\charrsid5443932 
\par }\pard\plain \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid12089427 \rtlch\fcs1 \af1\afs22\alang1025 \ltrch\fcs0 \f31506\fs22\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \f0\fs24\lang1024\langfe1024\noproof\insrsid15824599\charrsid5443932 9.\tab }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 
\hich\af0\dbch\af31505\loch\f0 Fischer, G.,Conceicao, F. R.,Leite, F. P. L.,Dummer, L. A\hich\af0\dbch\af31505\loch\f0 
.,Vargas, G. D. A.,Hubner, S. O.,Dellagostin, O. A.,Paulino, N.,Paulino, A. S. and Vidor, T. 2007. Immunimodulation produced by a green propolis extract on humoral and cellular responses of mice immunized with SuHV-1. Vaccine.}{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \b\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 25}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 : 1250\hich\f0 \endash \loch\f0 1256.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15824599\charrsid5443932 
\par }\pard\plain \ltrpar\s17\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid12089427 \rtlch\fcs1 \af37\afs22\alang1025 \ltrch\fcs0 \f37\fs22\lang1024\langfe1024\cgrid\noproof\langnp1033\langfenp1033 
{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid15824599\charrsid5443932 10.\tab }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 
\hich\af0\dbch\af31505\loch\f0 Fukushi, H.\hich\af0\dbch\af31505\loch\f0 ,Taniguchi, A.,Yasuda, K.,Yanai, T.,Masegi, T.,Yamaguchi, T. and Hirai, K. 2000. A hamster model of equine herpesvirus 9 induced encephalitis. J. Neurovirol. }{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \b\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 6}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 : 314\hich\f0 \endash \loch\f0 319.
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid15824599\charrsid5443932 11.\tab Fukushi, H., Tomita, T., Taniguchi, A., Ochiai, Y., Kirisawa, R., Matsumura, T., Y
anai, T., Masegi, T., Yamaguchi, T. and Hirai, K. Gazelle herpesvirus 1: a new neurotropic herpesvirus immunologically related to equine herpesvirus 1. Virology 227: 34-44. 1997.
\par }\pard\plain \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid12089427 \rtlch\fcs1 \af1\afs22\alang1025 \ltrch\fcs0 \f31506\fs22\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \f0\fs24\lang1024\langfe1024\noproof\insrsid15824599\charrsid5443932 12.\tab }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 
\hich\af0\dbch\af31505\loch\f0 Gao, W.,Wu, J.,Wei, J.,Pu, L.,Guo, C.,Yang, J.,Yanag, M. and Luo, H. 2014\hich\af0\dbch\af31505\loch\f0 . Brazilian green propolis improves immune function in aged mice. J. ClinBiochem. Nutr.}{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \b\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 55}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 : 7\hich\f0 \endash \loch\f0 10.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15824599\charrsid5443932 
\par }\pard\plain \ltrpar\s17\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid12089427 \rtlch\fcs1 \af37\afs22\alang1025 \ltrch\fcs0 \f37\fs22\lang1024\langfe1024\cgrid\noproof\langnp1033\langfenp1033 
{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid15824599\charrsid5443932 13.\tab }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid15098061\charrsid5443932 
Heinzel, F. P., Sadick, M. D., Holaday, B. J., Coffman, R. and Locksley, R. M. (1989). Reciprocal expression of interferon gamma or interleukin 4 during th
e resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J. Exp. Med. }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \b\f0\fs24\insrsid15098061\charrsid5443932 169: }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\insrsid15098061\charrsid5443932 59-72.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid15824599\charrsid5443932 
\par }\pard\plain \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid12089427 \rtlch\fcs1 \af1\afs22\alang1025 \ltrch\fcs0 \f31506\fs22\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \f0\fs24\lang1024\langfe1024\noproof\insrsid15824599\charrsid5443932 14.\tab }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 
\hich\af0\dbch\af31505\loch\f0 Maksimova-Todorova, V.,Gegova, G.,Serkedzhieva, Y.,Uzunov, S.,Pancheva, S.,Marekovand, N. andBankova, V. 1985. Antiv\hich\af0\dbch\af31505\loch\f0 iral effects of some fractions isolated from propolis.Acta.Mic. Bulg.}{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \b\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 17}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 : 79\hich\f0 \endash \loch\f0 85.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15824599\charrsid5443932 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\lang1024\langfe1024\noproof\insrsid15824599\charrsid5443932 15.\tab }{\rtlch\fcs1 \af63\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af63\hich\af63\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 \hich\af63\dbch\af31505\loch\f63 \hich\f63 Marcucci, M. C.,Ferreres, F.,Garc\'fd\loch\f63 
a-Viguera, C.,Bankova, V. S.,De Castro, S. L.,Dantas, A. P.,Valente, P. H. and Paulino, N. 2001. Phenolic compounds from Brazilian pr}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 opolis with pharmacological activities. J. Ethnopharmacol.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\b\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 74}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 : 105\hich\f0 \endash \loch\f0 112.
\par }\pard\plain \ltrpar\s17\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid12089427 \rtlch\fcs1 \af37\afs22\alang1025 \ltrch\fcs0 \f37\fs22\lang1024\langfe1024\cgrid\noproof\langnp1033\langfenp1033 
{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid15824599\charrsid5443932 16.\tab }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1024\langfe1024\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 
\hich\af0\dbch\af31505\loch\f0 Middleton, E. The impact of plant flavonoids on mammalian biology: implications for immunity, inflammation and cancer. pp. 145\hich\f0 \endash \loch\f0 166.In: Harborne JB. The flavonoids: Advances in Resea
\hich\af0\dbch\af31505\loch\f0 rch Since 1986, Chapman and Hall, London, U.K.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid15824599\charrsid5443932 
\par }\pard\plain \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid12089427 \rtlch\fcs1 \af1\afs22\alang1025 \ltrch\fcs0 \f31506\fs22\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \f0\fs24\lang1024\langfe1024\noproof\insrsid15824599\charrsid5443932 17.\tab }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 
\hich\af0\dbch\af31505\loch\f0 Narita, M.,Uchimura, A.,Kawanabe, M., Fukushi, H. andHirai, K. 2001. Invasion and spread of equine herpesvirus 9 in the olfactory pathway of pigs after intranasal inoculation. J. Comp. Pathol. }{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \b\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 124}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15098061\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 : 265\hich\f0 \endash \loch\f0 272.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15824599\charrsid5443932 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\lang1024\langfe1024\noproof\insrsid15824599\charrsid5443932 18.\tab }{\rtlch\fcs1 \af62\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af62\hich\af62\dbch\af31505\langfenp1041\insrsid14161673\charrsid5443932 \hich\af62\dbch\af31505\loch\f62 \hich\f62 
Nhiem, N. X.,Kiem, P. V.,Minh, C. V.,Tai, B. H.,Tung, N. H.,Soung, K. S., Kim, J. H.,Lee, Y. M. and Kim, Y. H. 2010. Structure-activity relationship of lupane-triterpene glycosides from Acanthopanaxkoreanum on spleen lymphocyte IL-2 and IFN-\'e3\loch\f62 
.Bioorg.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid14161673\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 Med Chem Lett.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\b\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid14161673\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 20}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid14161673\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 : 4927\hich\f0 \endash \loch\f0 4931.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15824599\charrsid5443932 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\lang1024\langfe1024\noproof\insrsid15824599\charrsid5443932 19.\tab }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid14161673\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 \hich\f0 Nina, N.,Quispe, C.,Jim\'e9\loch\f0 \hich\f0 nez-Aspee, F.,Theoduloz, C.,Feres\'ed\loch\f0 \hich\f0 
n, G. E.,Lima, B.,Leiva, E. and Schmeda-Hirshmann, G. 2015. Antibacterial activity, antioxidant effect and chemical composition of propolis from the Regi\'f3\loch\f0 ndel Maule,\hich\af0\dbch\af31505\loch\f0  central Chile. Molecules.}{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \b\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid14161673\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 20}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid14161673\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 : 18144\hich\f0 \endash \loch\f0 18167. }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15824599\charrsid5443932 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\lang1024\langfe1024\noproof\insrsid15824599\charrsid5443932 20.\tab }{\rtlch\fcs1 \af59\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af59\hich\af59\dbch\af31505\langfenp1041\insrsid14161673\charrsid5443932 \hich\af59\dbch\af31505\loch\f59 \hich\f59 Or\'9a\loch\f59 \hich\f59 oli\'e6\loch\f59 \hich\f59 , N. andBa\'9a\loch\f59 \hich\f59 i\'e6\loch\f59 
, I. 2005. Water-soluble derivative of propolis and its polyphenolic compounds enhance tumoricidal activity of macrophages. J. Ethnopharmacol. }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\b\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid14161673\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 102}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid14161673\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 : 37\hich\f0 \endash \loch\f0 45.
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\lang1024\langfe1024\noproof\insrsid15824599\charrsid5443932 21.\tab }{\rtlch\fcs1 \af59\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af59\hich\af59\dbch\af31505\langfenp1041\insrsid14161673\charrsid5443932 \hich\af59\dbch\af31505\loch\f59 \hich\f59 Or\'9a\loch\f59 \hich\f59 oli\'e6\loch\f59 \hich\f59 , N.,Terzi\'e6\loch\f59 \hich\f59 , S.,\'8a
\loch\f59 ver L\hich\af59\dbch\af31505\loch\f59 \hich\f59 . and Ba\'9a\loch\f59 \hich\f59 i\'e6\loch\f59 , I. 2005.Honey-bee products in prevention and/or therapy of murine transplantable tumours. J. Sci. Food Agric. }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\b\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid14161673\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 85}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid14161673\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 :363\hich\f0 \endash \loch\f0 370.
\par }\pard\plain \ltrpar\s17\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid12089427 \rtlch\fcs1 \af37\afs22\alang1025 \ltrch\fcs0 \f37\fs22\lang1024\langfe1024\cgrid\noproof\langnp1033\langfenp1033 
{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid15824599\charrsid5443932 22.\tab }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\lang1024\langfe1024\langfenp1041\insrsid14161673\charrsid5443932 \'d6zt\'fcrk, F., Kurt, E., Emiro\u487\'67
lu,L. and Sobaci, G. 1999.Effect of propolis on endotoxin-induced uveitis in rabbits. Jpn. J. Ophthalmol. }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \b\f0\fs24\cf17\lang1024\langfe1024\langfenp1041\insrsid14161673\charrsid5443932 43}{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \f0\fs24\cf17\lang1024\langfe1024\langfenp1041\insrsid14161673\charrsid5443932 :285\endash 289.
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid15824599\charrsid5443932 23.\tab }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid14161673\charrsid5443932 
Saleh, A. G., Anwar, S. I., Abas, O. M., Abd-Ellatieff, H. A., Nasr, M., Saleh, I., Fukushi, H. and Yanai, T. (2017). Effect of a single point mutation on equine herpes virus 9 (EHV-9) neuropathogenicity after intranasal in
oculation in a hamster model. J.Vet. Med. Sci. }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \b\f0\fs24\insrsid14161673\charrsid5443932 79: }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid14161673\charrsid5443932 1426-1436.}{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \f0\fs24\insrsid15824599\charrsid5443932 
\par }\pard\plain \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid12089427 \rtlch\fcs1 \af1\afs22\alang1025 \ltrch\fcs0 \f31506\fs22\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \f0\fs24\lang1024\langfe1024\noproof\insrsid15824599\charrsid5443932 24.\tab }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid1063652\charrsid5443932 
\hich\af0\dbch\af31505\loch\f0 Schnitzler, P.,Neuner, A\hich\af0\dbch\af31505\loch\f0 
.,Nolkemper, S.,Zundel, C.,Nowack, H.,Sensch, K. H. and Reichling, J. 2010. Antiviral activity and mode of action of propolis extracts and selected compounds.Phytother. Res.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\b\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid1063652\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 24}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid1063652\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 : 632.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15824599\charrsid5443932 
\par }\pard\plain \ltrpar\s17\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid12089427 \rtlch\fcs1 \af37\afs22\alang1025 \ltrch\fcs0 \f37\fs22\lang1024\langfe1024\cgrid\noproof\langnp1033\langfenp1033 
{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid15824599\charrsid5443932 25.\tab }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\lang1024\langfe1024\langfenp1041\insrsid1063652\charrsid5443932 
Sforcin. J.2007. Propolis and the immune system: a review. J Ethnopharmacol}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \b\f0\fs24\cf17\lang1024\langfe1024\langfenp1041\insrsid1063652\charrsid5443932 113:}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\cf17\lang1024\langfe1024\langfenp1041\insrsid1063652\charrsid5443932  1\endash 14.
\par }\pard\plain \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid12089427 \rtlch\fcs1 \af1\afs22\alang1025 \ltrch\fcs0 \f31506\fs22\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \f0\fs24\lang1024\langfe1024\noproof\insrsid15824599\charrsid5443932 26.\tab }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid1063652\charrsid5443932 
\hich\af0\dbch\af31505\loch\f0 Silva-Carvalho, R.,Baltazar, F. andAlmeida-Aguiar, C. 2015. Propolis: a complex natural product with a plethora of biological activities that can be explored for drug development. Evid Based Complement}{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid5443932\charrsid5443932 .}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid1063652\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 AlternatMed :206439.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid15824599\charrsid5443932 
\par }\pard\plain \ltrpar\s17\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid12089427 \rtlch\fcs1 \af37\afs22\alang1025 \ltrch\fcs0 \f37\fs22\lang1024\langfe1024\cgrid\noproof\langnp1033\langfenp1033 
{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid15824599\charrsid5443932 27.\tab }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid1063652\charrsid5443932 
Squires, K., Schreiber, R., McElrath, M., Rubin, B., Anderson, S. and Murray, H. (1989). Experimental visceral leishmaniasis: role of endogenous IFN-gamma in host defense and tissue granulomatous response. The.  J. Immunol.}{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \b\f0\fs24\insrsid1063652\charrsid5443932 143: }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid1063652\charrsid5443932 4244-4249.
\par }\pard\plain \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid12089427 \rtlch\fcs1 \af1\afs22\alang1025 \ltrch\fcs0 \f31506\fs22\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\lang1024\langfe1024\noproof\insrsid15824599\charrsid5443932 28.\tab }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid14693352\charrsid5443932 \hich\af0\dbch\af42\loch\f0 Taniguchi, A.\hich\af0\dbch\af42\loch\f0 
, Fukushi, H., Matsumura, T., Yanai, T., Masegi, T. and Hirai, K. 2000. Pathogenicity of a new neurotropic equine herpesvirus 9(gazelle herpesvirus 1) in horses. J. Vet. Med. Sci. }{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 
\b\fs24\loch\af0\hich\af0\dbch\af42\insrsid14693352\charrsid5443932 \hich\af0\dbch\af42\loch\f0 62}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid14693352\charrsid5443932 \hich\af0\dbch\af42\loch\f0 : 215\hich\f0 \endash 
\loch\f0 218.
\par }\pard\plain \ltrpar\s17\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid12089427 \rtlch\fcs1 \af37\afs22\alang1025 \ltrch\fcs0 \f37\fs22\lang1024\langfe1024\cgrid\noproof\langnp1033\langfenp1033 
{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid15824599\charrsid5443932 29.\tab }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid1063652\charrsid5443932 \hich\af0\dbch\af42\loch\f0 
Taniguchi, A., Fukushi, H., Yanai, T., Masegi, T., Yamaguch\hich\af0\dbch\af42\loch\f0 i, T. and Hirai, K. 2000. Equine herpesvirus 9 induced lethal encephalomyelitis in experimentally infected goats. Arch. Virol. }{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 
\b\fs24\loch\af0\hich\af0\dbch\af42\insrsid1063652\charrsid5443932 \hich\af0\dbch\af42\loch\f0 145}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid1063652\charrsid5443932 \hich\af0\dbch\af42\loch\f0 : 2619\hich\f0 \endash 
\loch\f0 2627.
\par }\pard\plain \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid12089427 \rtlch\fcs1 \af1\afs22\alang1025 \ltrch\fcs0 \f31506\fs22\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\lang1024\langfe1024\noproof\insrsid15824599\charrsid5443932 30.\tab Vernel-Pauillac, F., and F. Merien. Proinflammatory and immunomodulatory cytokine mRNA time course profiles in hamsters infected with a virulent variant of Leptospira interrogans
}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\lang1024\langfe1024\noproof\insrsid12089427\charrsid5443932 . 2006.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\lang1024\langfe1024\noproof\insrsid15824599\charrsid5443932 Infecand immun}{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \f0\fs24\lang1024\langfe1024\noproof\insrsid12089427\charrsid5443932 . }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\lang1024\langfe1024\noproof\insrsid15824599\charrsid5443932 74:4172-4179. }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\loch\af0\hich\af0\dbch\af42\insrsid15824599\charrsid5443932 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\lang1024\langfe1024\noproof\insrsid15824599\charrsid5443932 31.\tab }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid1063652\charrsid5443932 \hich\af0\dbch\af42\loch\f0 
Yanai, T., Fujishima, N., Fukushi, H\hich\af0\dbch\af42\loch\f0 ., Hirata, A., Sakai, H. and Masegi, T. 2003. Experimental infection of equine herpesvirus 9 in dogs.Vet. Pathol.}{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 
\b\fs24\loch\af0\hich\af0\dbch\af42\insrsid1063652\charrsid5443932 \hich\af0\dbch\af42\loch\f0 40}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid1063652\charrsid5443932 \hich\af0\dbch\af42\loch\f0 : 263\hich\f0 \endash 
\loch\f0 267.
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\lang1024\langfe1024\noproof\insrsid15824599\charrsid5443932 32.\tab }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid1063652\charrsid5443932 \hich\af0\dbch\af42\loch\f0 
Yanai, T., Sakai, T., Fukushi, H., Hirai, K., Narita, M., Sakai, H. and Masegi, T. 1998. Neuropathological study of gazelle he\hich\af0\dbch\af42\loch\f0 rpesvirus 1 (equine herpesvirus 9) infection in Thomson\hich\f0 \rquote \loch\f0 
s gazelles (Gazella thomsoni). J. Comp. Pathol. }{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \b\fs24\loch\af0\hich\af0\dbch\af42\insrsid1063652\charrsid5443932 \hich\af0\dbch\af42\loch\f0 119}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\loch\af0\hich\af0\dbch\af42\insrsid1063652\charrsid5443932 \hich\af0\dbch\af42\loch\f0 : 159\hich\f0 \endash \loch\f0 168.
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\lang1024\langfe1024\noproof\insrsid15824599\charrsid5443932 33.\tab }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid1063652\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 
Yao, L.,Jiang, Y.,D'Arcy, B.,Singanusong, R.,Datta, N.,Caffin, N. and Raymont, K. 2004. Quantitative high-performance liquid chromatog\hich\af0\dbch\af31505\loch\f0 raphy analyses of flavonoids in Australian Eucalyptus honeys. J. Agric. Food Chem. }{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \b\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid1063652\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 52}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid1063652\charrsid5443932 \hich\af0\dbch\af31505\loch\f0 :210\hich\f0 \endash \loch\f0 214.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid1063652 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf17\lang1033\langfe1041\loch\af0\hich\af0\dbch\af31505\langfenp1041\insrsid5443932 
\par 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid5443932\charrsid5443932 
\par }\pard\plain \ltrpar\s17\ql \li0\ri0\sa200\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid12089427 \rtlch\fcs1 \af37\afs22\alang1025 \ltrch\fcs0 
\f37\fs22\lang1024\langfe1024\cgrid\noproof\langnp1033\langfenp1033 }}\pard\plain \ltrpar\s17\ql \li0\ri0\sa200\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid12089427 \rtlch\fcs1 \af37\afs22\alang1025 
\ltrch\fcs0 \f37\fs22\lang1024\langfe1024\cgrid\noproof\langnp1033\langfenp1033 \sectd \ltrsect\sbknone\linemod1\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid4810808\sftnbj {\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 
\b\f0\fs24\cf17\lang1024\langfe1024\langfenp1041\insrsid2785103\charrsid3148030 
\par }\pard\plain \ltrpar\ql \qk10\fi-361\li361\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin361\itap0\cufi-150\pararsid3148030 \rtlch\fcs1 \af1\afs22\alang1025 \ltrch\fcs0 \f31506\fs22\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 
\ab\af0\afs24 \ltrch\fcs0 \b\f0\fs24\cf17\lang1033\langfe1041\langfenp1041\insrsid16670798\charrsid3148030 Figure legands;}{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \b\f0\fs24\cf17\lang1033\langfe1041\langfenp1041\insrsid3175524\charrsid3148030 
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid5443932 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid16670798\charrsid16670798 Fig. }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid16079814 1}{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid16670798\charrsid16670798 .}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid16670798\charrsid16670798 \hich\af0\dbch\af42\loch\f0 
Non-suppurative meningoencephalitis in hamsters infected with EHV-9}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid16670798 \hich\af0\dbch\af42\loch\f0 and propolis treated }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\loch\af0\hich\af0\dbch\af42\insrsid3148030 \hich\af0\dbch\af42\loch\f0 represented by; (A) perivascular cuffing (arrows);}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid3148030\charrsid16670798 
\hich\af0\dbch\af42\loch\f0 (B)meningoencephalitis}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid3148030 \hich\af0\dbch\af42\loch\f0  (arrows),with also perivascular cuffing (arrowhead)}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\loch\af0\hich\af0\dbch\af42\insrsid16670798\charrsid16670798 \hich\af0\dbch\af42\loch\f0 , H&E, Bar=}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid3148030 \hich\af0\dbch\af42\loch\f0 5}{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid16670798\charrsid16670798 \hich\af0\dbch\af42\loch\f0 0 }{\rtlch\fcs1 \ai\af62\afs24 \ltrch\fcs0 \i\fs24\loch\af62\hich\af62\dbch\af42\insrsid16670798\charrsid16670798 \loch\af62\dbch\af42\hich\f62 \'ec
}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid16670798\charrsid16670798 \hich\af0\dbch\af42\loch\f0 m}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid3148030 \hich\af0\dbch\af42\loch\f0 ;}{
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid16670798\charrsid16670798 \hich\af0\dbch\af42\loch\f0  (C) Neuronal degeneration and necrosis with nuclear shrinkage and vacuolation (arrows). H&E, Bar=}{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid3148030 \hich\af0\dbch\af42\loch\f0 2}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid16670798\charrsid16670798 \hich\af0\dbch\af42\loch\f0 0 }{\rtlch\fcs1 \ai\af62\afs24 
\ltrch\fcs0 \i\fs24\loch\af62\hich\af62\dbch\af42\insrsid16670798\charrsid16670798 \loch\af62\dbch\af42\hich\f62 \'ec}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid3148030 \hich\af0\dbch\af42\loch\f0 m; (D) }{\rtlch\fcs1 
\af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid3148030\charrsid3148030 \hich\af0\dbch\af42\loch\f0 Immuno\hich\af0\dbch\af42\loch\f0 histochem}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid3148030 
\hich\af0\dbch\af42\loch\f0 istry for viral distribution in }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid3148030\charrsid3148030 \hich\af0\dbch\af42\loch\f0 the brain. Viral antigens}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\loch\af0\hich\af0\dbch\af42\insrsid3148030 \hich\af0\dbch\af42\loch\f0  were localized in the neuronal }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid3148030\charrsid3148030 \hich\af0\dbch\af42\loch\f0 
body (arrows), processes }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid3148030 \hich\af0\dbch\af42\loch\f0 arrowhead), }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid3148030\charrsid3148030 
\hich\af0\dbch\af42\loch\f0 Bar=50 }{\rtlch\fcs1 \ai\af62\afs24 \ltrch\fcs0 \i\fs24\loch\af62\hich\af62\dbch\af42\insrsid3148030\charrsid3148030 \loch\af62\dbch\af42\hich\f62 \'ec}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\loch\af0\hich\af0\dbch\af42\insrsid3148030\charrsid3148030 \hich\af0\dbch\af42\loch\f0 m.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid16670798 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\loch\af0\hich\af0\dbch\af42\insrsid3148030\charrsid3148030 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid16670798\charrsid16670798 Fig. 2. Cytokine mRNA expression in brain tissues of propolis infected hamsters. Target gene expression is pr}{\rtlch\fcs1 \af62\afs24 \ltrch\fcs0 
\f62\fs24\insrsid16670798\charrsid16670798 esented relative to \'e2-actin expression and normalized to a calibrator. }{\rtlch\fcs1 \af62\afs24 \ltrch\fcs0 \fs24\loch\af62\hich\af62\dbch\af42\insrsid10243114 \hich\af62\dbch\af42\loch\f62 \hich\f62 
(A)  represent the  relative increase of IL2,IL-10.IFN-\'e3\loch\f62   in relation to the control un infected hamsters at D1,D2,D3,D4PI. (B) }{\rtlch\fcs1 \af62\afs24 \ltrch\fcs0 \fs24\loch\af62\hich\af62\dbch\af42\insrsid13647458 
\hich\af62\dbch\af42\loch\f62 \hich\f62 IL-2,(C) IL-10,(IFN-\'e3\loch\f62  ) respectively. }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\insrsid16670798\charrsid16670798 
The difference between both groups was assessed by two-way ANOVA analysis of variance. Comparisons were considered significant at }{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\f0\fs24\insrsid16670798\charrsid16670798 P}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\f0\fs24\insrsid16670798\charrsid16670798 \u8804\'3d0.05. 
\par }\pard \ltrpar\ql \qk10\li0\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid12670252 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\lang1033\langfe1041\langfenp1041\insrsid16079814 
\par }\pard \ltrpar\ql \qk10\fi-361\li361\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin361\itap0\cufi-150\pararsid16079814 {\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \b\f0\fs24\cf17\lang1033\langfe1041\langfenp1041\insrsid16079814\charrsid16079814 
Table legands;
\par }\pard \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16079814 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\f0\insrsid16079814\charrsid16079814 Table 1.}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 
\b\f0\insrsid12670252  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \loch\af0\hich\af0\dbch\af42\insrsid16079814\charrsid16079814 \hich\af0\dbch\af42\loch\f0 Experimental design for the groups of hamsters}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\loch\af0\hich\af0\dbch\af42\insrsid5443932 .}{\rtlch\fcs1 \af0 \ltrch\fcs0 \loch\af0\hich\af0\dbch\af42\insrsid16079814\charrsid16079814 
\par }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\f0\insrsid16079814\charrsid16079814 Table 2.}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\f0\insrsid12670252  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \loch\af0\hich\af0\dbch\af42\insrsid16079814\charrsid16079814 
\hich\af0\dbch\af42\loch\f0 The rate of infection at each day \hich\af0\dbch\af42\loch\f0 of the experiment}{\rtlch\fcs1 \af0 \ltrch\fcs0 \loch\af0\hich\af0\dbch\af42\insrsid5443932 .}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\loch\af0\hich\af0\dbch\af42\insrsid16079814\charrsid16079814 
\par }\pard \ltrpar\ql \qk10\fi-360\li360\ri0\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin360\itap0\cufi-150\pararsid7956005 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24\cf17\lang1033\langfe1041\langfenp1041\insrsid16079814\charrsid7956005 
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Youez - 2016 - github.com/yon3zu
LinuXploit