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Title: Conjunctival kaposi sarcoma revealing HIV infection

Authors: Amel Chebbi1, Imen Abbes2, Houda Lajmi1, Ines Malek1, Imen Zeghal1, Karima MRAD2, Hedi Bouguila1, Leila Nacef1. 
(1) Department A of ophthalmology, Hedi Rae�s Institute. Tunis.
(2) Department of Pathology, Salah Azae�z Institute. Tunis.

Corresponding author:  DR Amel CHEBBI 
Adresse: BP 155. Menzeh 7. Tunis
Phone number: +216 24960828
Mail: HYPERLINK "mailto:amel.chenaoui@yahoo.fr"amel.chenaoui@yahoo.fr
Conflict of Interest: none












CONJUNCTIVAL KAPOSI SARCOMA REVEALING HIV INFECTION
ABSTRACT 
Kaposi�s sarcoma is a rare condition due to HHV8 viral infection which is common in patients with AIDS. Ocular location is rare and conjunctival forms represent 7 to 18%. It usually occurs in the context of a multicentric disease. Isolated ocular involvement is extremely rare.
We report a case of a woman with a Kaposi's sarcoma of the bulbar conjunctiva that revealed infection with human immunodeficiency virus. 

KEY WORDS: Kaposi�s sarcoma; HHV-8; conjunctival tumor; histopathology; highly active antiretroviral therapy.










INTRODUCTION 
Kaposi�s sarcoma (KS) is a rare condition due to Human Herpes Virus-8(HHV8) infection.  It is commonly encountered in patients with acquired immunodeficiency syndrome (AIDS), other deep immune deficiency or organ transplantation. 
Four clinico-epidemiologic forms of KS have been described and designated as classic, endemic, iatrogenic, and epidemic. The classic form is first described by Moritz Kaposi in 1872 [1], the epidemic form is due to human immunodeficiency virus [HIV] infection, the endemic form described in Sub-Saharan Africa, and the iatrogenic form occurring after organ transplant or iatrogenic immunosuppression.
Since then, there has been a lot of progress in the comprehension of its physiopathology, histopathology, clinical course and treatment.  A conjunctival location is, however, rare, and only 30 cases have been described in the literature. Only 20% of AIDS patients suffering from KS have ocular manifestations (lids or conjunctiva) and in 12% of cases ocular involvement is the primary manifestation [2-3]. We report a case of conjunctival KS revealing HIV infection in a woman, managed successfully with surgical excision.

CASE REPORT
A 38 years old woman with no medical history was referred to our department to investigate a vascular tumefaction of the inferior bulbar conjunctiva of the right eye. This tumefaction was noticed by the patient since two months. Best corrected visual acuity in the right eye was of 10/10 P2. The examination of the conjunctiva revealed a bulbar tumefaction near the inferior fornix, measuring 12/ 6/ 5 mm. The tumor was painless, purple, oblong, prominent, and polished (Figure 1). There was no evidence of orbital or scleral invasion. The rest of biomicroscopic examination of both eyes was normal. This aspect was evocative of hemangioma; thus an excision biopsy respecting a safety margin of 2 mm with an over-and-over suture of a conjunctival rotation flap were performed.
The histopathological examination of the specimen revealed a fasciculate spindle cell proliferation, with mild to moderate atypia and scattered mitosis, intermixed with slit like vascular spaces (Figure 2). Erythrocytes were seen within the vascular spaces and throughout the tumor. Some intra and extra cellular hyaline globules and scattered lymphocytes were noted too. Immunohistochemistry revealed CD31 (figure 3) and HHV8 latent nuclear antigen 1(LNA-1) immunostaining of the tumor cells (Figure 4). 
An etiological assessment was performed and revealed a normal Chest X ray and lymphopenia with a CD4 cell count of 214 cells/mm3. The serological examination for HIV-1 and 2 were positive. There were no other tumor locations especially visceral locations. The patient underwent anti retroviral treatment and no evidence of recurrence 12 month after surgery was seen (figure 5).
DISCUSSION 
KS is the most common tumor arising in HIV infected patients and is an AIDS-defining illness according to Centers for Disease Control guidelines. 
In the usual way, skin lesions often coincide with pulmonary, gastrointestinal or hepato-splenic involvement which is considered as a frequent autopsy, finding rarely diagnosed at life. In patients with advanced AIDS, Kaposi�s sarcoma will often disseminate to involve the oro-pharynx, larynx, tracheo-bronchial tree, lungs, and other viscera. In these cases, patients died because of the tumor itself [5]. 
Ocular KS has been uncommonly described in the literature [1]. Virtually, most of the cases in which conjunctival lesions were reported, the palpebral or fornix conjunctiva were involved. Indeed, conjunctival locations are present in 7-18% of cases [2]. The bulbar conjunctiva involvement, as seen in our case, is infrequent. Besides, it is an AIDS-related Kaposi sarcoma revealed by ophthalmic involvement which is even more unusual. 
HHV-8 infection appears to be necessary for the development of KS. In fact, the virus was found in 100% of studied KS cases [2,6].
HHV-8 expresses some genes during latency, whereas others are expressed during the lytic phase of replication and play a role in tumorigenesis through control of the cell cycle and regulation of apoptosis. LANA-1(latency-associated nuclear antigen 1) for example represses the transcriptional activity of p53, preventing its ability to trigger apoptosis [7-9].
However, only a small proportion of HHV-8 infected people develop the tumor suggesting that other factors especially declining immune function and HIV infection are involved [10].
In fact, the HIV involvement was advanced by studies showing that HIV-infected CD4 lymphocytes can produce extracellular factors that potentiate the growth of KS tumor cells such as the Tat protein which protects KS cells from apoptosis and promotes the growth of lesion spindle cells [1, 11, 12].
Immunosupression plays a role in KS genesis. Many studies show that immune enhancement in transplanted patients or starting up of anti retroviral treatments could induce KS regression or recovery [13-15]. 
The lesion, as we noticed in our patient, was typically oblong, purple-red and polished because of its epithelial covering with sub conjunctival extension that could invade all the fornix. The tumor was integral with the conjunctiva when it was mobilized on the deep sclera plane. 
According to its clinical presentation, the KS tumor is classified into three stages: stage 1: focal and flat lesions less than 3 mm of thickness, stage 2: flat tumors of 3mm thickness lasting for less than four months, and stage 3: prominent tumors more than 3mm of thickness lasting for more than four months [16]
The conjunctival lesions are easily mistaken for other benign or malignant conjunctival tumors, such as conjunctival papilloma, chronic sub conjunctival hemorrhage, foreign body granuloma, pyogenic granuloma, bleu malignant nevus, bacterial angioma and vascular malformations.
KS is histologically characterized by neo-angiogenesis and proliferating spindle-shaped cells
admixed with an inflammatory infiltrate of lymphocytes and plasma cells [16].  The origin of the malignant spindle cells was not apparent. They have been variously ascribed to endothelial cell, muscle cell, and nerve cell origin. Nowadays, it is known that spindles cells show positive immunostaining to endothelial markers such as CD31 and CD34 suggesting their endothelial origin. The nuclear immunohistochemical detection of human herpes virus-8 latent nuclear antigen (LANA-1), as shown in our case, proved the presence of human herpes virus 8 (HHV-8) in all forms of KS. In fact, endothelial cells lining the vascular slits express LANA-1[17-18]. 
The epidemic form of KS is the most aggressive, frequently occurring in multicentric fashion with involvement of skin, mucosal membranes, lymph nodes, and the visceral cavity [19]. Searching for other locations was compulsory in this case and based on a precise questioning, a general examination, and biological investigations such as CD4 cell counts, virological and immunological tests (immunofluorescence, Western blot or ELISA and PCR).  
Epidemic KS responds very well to highly active antiretroviral therapy (HAART). The benefits of HAART  is due to the inhibition of HIV replication, diminished production of Tat protein, amelioration of the host�s immune response to HHV8, and the direct anti-angiogenic activity of some protease inhibitors [12]. However, it may flare dramatically following the initiation of effective HAART or during the immune reconstitution inflammatory syndrome (IRIS) [20]. This syndrome is an unusual inflammatory reaction to an infection or other disease process that occurs in HIV-positive patients with profound immunosuppression during the reconstitution of immunity associated with HAART. furthermore, the delay of action of HAART regimens might be long (3 to 6 months), therefore , it is important to begin  a local or a general specific treatment.
The local treatment consists in surgery, cryotherapy, laser or intra lesional treatments (cytostatics, cidofovir, Interleukin 2 and interferon).
Dugel and al [16] proposed a therapeutic schema based on clinical and histological stages. For conjunctival tumors stages 1 and 2 (in bulbar conjunctiva), the excision biopsy made in 1 to 2 mm in safe area is sufficient. For stage 3, they recommend an angiofluographic delimitation of the lesion borders before surgery to avoid missing infraclinical lesions. For surgery inaccessible tumors, the radiotherapy by 20 to 30 grays in two or three sessions for three weeks seems to be the best option. After a satisfactory treatment, recurrences rate is about 50% [21, 22].
Rodrigez and al [23] proposed a complete excision biopsy with a safety margin and amniotic membrane transplantation for unique and bulbar KS with good carcinologic and functional outcomes. Recent studies with topic and intra lesional alpha 2a Interferon [24] and adjuvant radiotherapy with strontium-90 [25] in conjunctival KS are encouraging.
Anti herpetic therapies (foscavir, cidofovir and ganciclovir) are deceiving either for the treatment or the prophylaxis [26].  There are many potential targets for KS therapies which are now the focus of several studies (anti angiogenic agents, NFkb inhibitors, anti Interleukin 6, anti STAT3 and pegylated liposomal doxorubicin for patients with HIV-associated Kaposi�s sarcoma and other new treatments [10, 27].

CONCLUSION 
The prognosis of conjonctival KS in HIV-infected patients has been considerably improved by the use of modern antiretrovirals, which represent the cornerstones of therapy. The surgical management associated with cryotherapy or radiotherapy allows local control of the tumor. Tumor recovery or stabilization may be obtained by improving immunodepressive state. Exciting novel therapies proving our understanding of the underlying pathophysiology of KS will revolutionize the control of the disease. 

REFERENCES 
1.  Scheschonka A, Krieglsteiner M, Turowski B, Zanella FE (2003). Pre- and post treatment MR Imaging in AIDS-Related Kaposi Sarcoma of the conjunctiva and lacrimal gland. Am J Neuroradiol 24:1327-1329.
2.   Kalinske M, Leone Jr CR (1982). Kaposi�s sarcoma involving eyelid and conjunctiva. Ann Ophthalmol 14:497-499.
3.  Schmid K, Wild T, Bolz M, Horvat R, Jurecka W, Zehetmayer M (2003).  Kaposi�s sarcoma of the conjunctiva leads to a diagnosis of acquired immunodeficiency syndrome. Acta Ophthalmol Scand  81:411-413.
4. Zaraa I, Labb�ne I, El Guellali N, Ben Alaya N, Mokni M, et al (2012).  Kaposi�s disease: Epidemiological, clinical, anatomopathological and therapeutic features in 75 patients. La tunisie Medicale 90: 116-121. 
5. Faghihi G, Radan M, Taheri S (2009). Kaposi Sarcoma with visceral involvement in a HIV- Neg female patient. The Open Circulation and Vascular Journal 2:37-39. 
6. Schulz TF, Sheldon J, Greensill J (2002). Kaposi�s sarcoma associated herpes virus (KSHV) or human herpes virus 8 (HHV8). Virus Res 82: 115-126.
7. Sarid R, Olsen SJ, Moore PS (1999). Kaposi�s sarcoma-associated herpesvirus: epidemiology, virology, and molecular biology. Adv Virus Res 52:139-232.
8.  Djerbi M, Screpanti V, Catrina AI, Bogen B, Biberfeld P, and al (1999). The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors. J Exp Med 190:1025-1032.
9. Roupelieva M, Griffiths SJ, Kremmer E, Meisterernst M, Viejo-Borbolla A (2010). Kaposi�s sarcoma-associated herpesvirus Lana-1 is a major activator of the serum response element and mitogen-activated protein kinase pathways via interactions with the Mediator complex Journal of General Virology 91:1138-1149.
10. Cainelli F,Vallone A (2009). Safety and efficacy of pegylated liposomal doxorubicin in HIV-associated Kaposi�s sarcoma. Biologics:Targets & Therapy 3:385-390.
11.  Bou� F, Lebb� L (2003). Kaposi�s sarcoma. Bull Cancer 90: 393-398.
12. Cheung MC, Pantanowitz L, Dezube BJ (2005). AIDS-Related Malignancies: Emerging Challenges in the Era of Highly Active Antiretroviral Therapy. The Oncologist 10:412-426.
13.  Penn I (1997). Kaposi�s sarcoma in transplant recipients. Transplantation 64: 669-673. 
14. Pellet C, Chevret S, Blum L, Gauville C, Hurault M, and al (2001). Virologic and immunologic parameters that predict clinical response of AIDS-associated Kaposi�s sarcoma to highly active antiretroviral therapy. J Invest Dermatol 117: 858-863.
15. Sneller MC, Strober W, Eisenstein E, Jaffe JS, Cunningham-Rundles C (1993). NIH conference: new insights into common variable immunodeficiency. Ann Intern Med 188:720-730. 
16.  Dugel PV, Parkash SG, Frangieh GT, Ral NA (1990). Ocular adnexal Kaposi�s sarcoma in aquired immunodeficiency syndrome. Am J Ophthalmol 110:500-503. 
17.  Lebbe C, Legendre C, Frances C (2008). Kaposi sarcoma in transplantation. Transplant Rev 22:  252- 261. 
18. Lan K, Kuppers DA, Verma SC, Robertson ES (2004). Kaposi�s sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen inhibits lytic replication by targeting Rta: a potential mechanism for virus-mediated control of latency. J Virol 78: 6585-6594.
19. Reiser BJ, Mok A, Kukes G, Kim J (2007). Non�AIDS-Related Kaposi Sarcoma Involving the Tarsal Conjunctiva and Eyelid Margin .Arch Ophthalmol 125: 838-840.
20. Connick E, Kane MA, White IE, Ryder J, Campbell TB, and al (2004). Immune reconstitution inflammatory syndrome associated with Kaposi sarcoma during potent antiretroviral therapy. Clin Infect Dis 39:1852-1853.
21. Sudzinskia J, Thomasa T, Berthouta A, Gonthierb MF, Lumbroso-Le Rouic L, and al (2009). Sarcome conjonctival de Kaposi. Journal fran�ais d�ophtalmologie 32:151-155. 
22. HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed?term=Mikropoulos%20D%5BAuthor%5D&cauthor=true&cauthor_uid=21734889"Mikropoulos D,�HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed?term=Mavrikakis%20I%5BAuthor%5D&cauthor=true&cauthor_uid=21734889"Mavrikakis I,�HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed?term=Ziakas%20NG%5BAuthor%5D&cauthor=true&cauthor_uid=21734889"Ziakas NG,�HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed?term=Konstas%20AG%5BAuthor%5D&cauthor=true&cauthor_uid=21734889"Konstas AG,�HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed?term=Boboridis%20KG%5BAuthor%5D&cauthor=true&cauthor_uid=21734889"Boboridis KG (2011). Kaposi's�sarcoma�of the�Bulbar�Conjunctiva�in an�Immunocompetent�patient. HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed/?term=Kaposi%E2%80%99s+Sarcoma+of+the+Bulbar+Conjunctiva+in+an+Immunocompetent+Patient" \o "Case reports in ophthalmology."Case Rep Ophthalmol�2:193-197.
23.  Rodriguez-P�rez C, Gris-Castellono O, Soler-lluis N, Del Campocarrasco Z, Wolley-Dod C (2005). Amniotic membrane transplantation after surgical resection in conjunctival kaposi�s sarcoma. Arch Soc Esp Oftalmol 80:525-528.
24. HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed?term=Qureshi%20YA%5BAuthor%5D&cauthor=true&cauthor_uid=19654515"Qureshi YA�,�HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed?term=Karp%20CL%5BAuthor%5D&cauthor=true&cauthor_uid=19654515"Karp CL�,�HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed?term=Dubovy%20SR%5BAuthor%5D&cauthor=true&cauthor_uid=19654515"Dubovy SR (2009). Traitement par l'interf�ron alpha-2b intralesional pour annexielle�sarcome de Kaposi. HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed/19654515" \o "Corn�e."Corn�e 28: 941-943.
25. HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed?term=Brunt%20AM%5BAuthor%5D&cauthor=true&cauthor_uid=2261395"Brunt AM,�HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed?term=Phillips%20RH%5BAuthor%5D&cauthor=true&cauthor_uid=2261395"Phillips RH (1990). Strontium-90 for�conjunctival�AIDS-related Kaposi�s sarcoma : the first case report. HYPERLINK "http://www.sciencedirect.com/science/journal/09366555" \o "Go to Clinical Oncology on ScienceDirect"Clinical Oncology 2:118-119. 
26. Frances C, Marcelin AG, Legendre C, Chevret S, Dussaix E, and al (2009). The impact of preexisting or acquired Kaposi sarcoma herpesvirus infection in kidney transplant recipients on morbidity and survival. American journal of transplantation 9: 2580-2586.
27. St�rzl M, Zietz C, Eisenburg B, Goebel FD, Gillitzer R, and al (1994). Liposomal doxorubicin in the treatment of AIDS-associated Kaposi�s sarcoma: clinical, histological and cell biological evaluation. Res Virol 145:1-9.
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