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��ࡱ�>��	`b����UVWXYZ[\]^_����������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������	��,[bjbj��	8�x�x�S
��������	�	����8MiD�T���W(W(W(W(~)�0�f3p�T�T�T�T�T�T�T�V�*YT�T�4~)~)�4�4�TW(W('�T�;�;�;�4RW(W(�C��;�4�T�;�;�=>W(����@��ߑJ�(;��=�C�T0�T�=,~Y�;.~Y>~Y>��4�4�;�4�4�4�4�4�T�T�;�4�4�4�T�4�4�4�4��������������������������������������������������������������������~Y�4�4�4�4�4�4�4�4�4�		�:	Title: Pharmacogenetics of Apolipoprotein E on Donepezil and Fluoxetine Pharmacotherapy for Chemotherapeutic Induced Neurocognitive Decline
Running title: Pharmacotherapy for Cognitive Decline

Carmen E. Couvertier-Lebr�n1, Pura Garcia-Serrablo1, Summer F. Acevedo2

1Psychology Program, Ponce School of Medicine and Health Sciences, Ponce, Puerto Rico. 2Department of Psychiatry, UT Southwestern Medical Center, Dallas, Texas 

Correspondence should be addressed to:
Summer F. Acevedo, Ph.D. 
Instructor
UT Southwestern Medical Center
2201 Inwood Rd
Dallas, TX 75235
(214) 648-1170
Summer.Acevedo@UTSouthwestern.edu

Abstract
Chemotherapeutic drugs are designed to target and kill cancer cells, but significant evidence indicate they also attack other cells including neurons which in some cases leads to long-term neurocognitive deficits. Who will be affected and how much, remains a mystery. The aim of this review is to examine the potential use of pharmacotherapy�s (Donepezil, Fluoxetine) as a preventive treatment to assist and managing the effects of chemotherapeutic agents. In addition, this review examines how genetic variations in Apolipoprotein E (ApoE) may alter response to these drugs and should be considered early as a confounding factor. The review suggests that more research is needed on the relationship between an individual�s genetics response to treatment to identify those most likely to benefit from preventive pharmacotherapy. The long-term goal would be for both clinicians and patients to know how important genetic knowledge is, when making their decision in designing and accepting a medical recommendation for therapy. 


Keywords: ApoE; Donepezil; Fluoxetine; Pharmacotherapy; Cognition; ChemotherapyIntroduction
	Understanding that cancer is a serious condition at any stage, the first question usually asked to the doctor is �what treatment will make me better�? The doctor balances all available information regarding type of cancer, location, and stage then identifies a treatment plan. In addition to surgery, most patients diagnosed with breast or gynecological cancers need to undergo chemotherapy treatment to fully stop and eliminate tumor growth. Chemotherapeutic drugs are harsh chemical toxins that affect more than just cancer cells and can lead to various side effects including nausea, vomiting, fatigue, infection, and neuropathy  ADDIN EN.CITE <EndNote><Cite><Author>Fan</Author><Year>2007</Year><RecNum>460</RecNum><DisplayText>[1]</DisplayText><record><rec-number>460</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">460</key><key app="ENWeb" db-id="TWVFEgrtqgcAAHXhYvY">485</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Fan, G.</author><author>Filipczak, L.</author><author>Chow, E.</author></authors></contributors><titles><title>Symptom clusters in cancer patients: a review of the literature.</title><secondary-title>Curr Oncol</secondary-title><alt-title>Current Oncology (Toronto, Ont</alt-title></titles><periodical><full-title>Curr Oncol</full-title><abbr-1>Current oncology (Toronto, Ont</abbr-1></periodical><alt-periodical><full-title>Curr Oncol</full-title><abbr-1>Current oncology (Toronto, Ont</abbr-1></alt-periodical><pages>173-9</pages><volume>14</volume><number>5</number><dates><year>2007</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>1198-0052 (Print)</isbn><accession-num>17938700</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=17938700</url></related-urls></urls><language>eng</language></record></Cite></EndNote>[HYPERLINK \l "_ENREF_1" \o "Fan, 2007 #460"1]. Those that can cross the blood brain barrier can also affect an individual�s neurons leading to neuronal cell damage and cognitive dysfunction. 
If you ask survivors, most will report that chemotherapy treatments diminished their powers of recall leading to feelings of disorientation that in most cases dismissing daily functioning  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_2" \o "Myers, 2010 #1871"2-6]. The chemicals that are used in chemotherapy induce negative effects on neurons involved in cognitive processing leading to what has become known as Chemo-brain or Chemo-fog. These terms are used to describe the cognitive decline some patients experience post-chemotherapy  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_6" \o "Dietrich, 2006 #2359"6-10]. As both the patient and the doctor are often so focused on the treatment of the tumor the potential side effects of treatments are not commonly discussed in designing a course of treatment. Adult, unlike those with childhood cancers, patients are not routinely examined pre and post-chemotherapy for long-term cognitive effects nor are they told of the potential side effects.
	In rodent models when 5-Flourouracil (5-FU), one of the most commonly used chemotherapy drugs for treatment of breast cancer, is administered systemically it leads to damage in the central nervous system (CNS)  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_11" \o "Han, 2008 #2294"11]. Examinations of the hippocampus, an area of the brain necessary for working memory, after injections of methotrexate (MTX) or the Cyclophosphamide, MTX, and 5-FU (CMF) combination indicate that there is reduced hippocampal neuronal cell proliferation  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_12" \o "Seigers, 2008 #1320"12-14]. In addition, carmustine (BCNU), cisplatin, and cytosine arabinoside (cytarabine), drugs used most commonly to treat gynecological cancers, injected into mice lead to increased neuronal cell death in the sub-ventricular zone, dentate gyrus of the hippocampus, and the corpus callosum  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_6" \o "Dietrich, 2006 #2359"6]. This is consistent with clinical studies finding that female breast cancer survivors have smaller grey matter and white matter after undergoing chemotherapy, particularly in the parahippocampal gyrus and prefrontal regions  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_15" \o "Inagaki, 2007 #2332"15-18], areas that are important for attention and working memory processes.
More than 30 reviews on the clinical research compiled over the last 30 years on female cancer survivors, indicates a large varied list of different cognitive domains and neuropsychological assessments affected after chemotherapy  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_4" \o "Nelson, 2007 #1025"4, HYPERLINK \l "_ENREF_7" \o "Ahles, 2001 #34"7, HYPERLINK \l "_ENREF_19" \o "Castellon, 2005 #269"19-28]. These studies indicate that as many as 60% of female breast cancer survivors display cognitive decline at 3 week post-treatment. Additionally, 17- 28% demonstrate cognitive decline after a standard dose of chemotherapy 3-8 years post-treatment  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_4" \o "Nelson, 2007 #1025"4, HYPERLINK \l "_ENREF_7" \o "Ahles, 2001 #34"7, HYPERLINK \l "_ENREF_29" \o "Wieneke, 1995 #1592"29]. The most common reported impairments are in visual memory, verbal memory, and executive functions. 
The treatments used and confounding variables are so many it is hard to point to any one treatment or cognitive outcome. Rodent models allow for examination of individual treatment regiments and genetic confounding variables to assess potential chemotherapeutic effects on long-term cognitive outcomes. The major issue is that pharmaceutical companies and most research focuses only on primary treatment response not the neurocognitive side-effects. Only the few most commonly used breast cancer chemotherapeutic agents have been examined, those studies clearly show that MTX, 5-FU or the CMF treatment regiment induce visuospatial memory deficits in Morris Water Maze (MWM)  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_13" \o "Seigers, 2009 #1319"13, HYPERLINK \l "_ENREF_30" \o "Winocur, 2006 #1605"30]. This is consistent with a clinical study that utilized a human version of MWM called �Memory Island�, the researchers found that female breast cancer survivors whom had undergone chemotherapy treatment display reduced memory compared to health women  ADDIN EN.CITE <EndNote><Cite><Author>Ayala-Feliciano</Author><Year>2011</Year><RecNum>2457</RecNum><DisplayText>[31]</DisplayText><record><rec-number>2457</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2457</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ayala-Feliciano, M.</author><author>Pons-Valerio, J. J.</author><author>Pons-Madera, J.</author><author>Acevedo, S. F.</author></authors></contributors><auth-address>Clinical Psychology Program.</auth-address><titles><title>The Relationship between Visuospatial Memory and Coping Strategies in Breast Cancer Survivors</title><secondary-title>Breast Cancer (Auckl)</secondary-title><alt-title>Breast Cancer: Basic and Clinical Research</alt-title></titles><periodical><full-title>Breast Cancer (Auckl)</full-title></periodical><alt-periodical><full-title>Breast Cancer: Basic and Clinical Research</full-title></alt-periodical><pages>117-30</pages><volume>5</volume><edition>2011/06/23</edition><dates><year>2011</year></dates><isbn>1178-2234 (Electronic)&#xD;1178-2234 (Linking)</isbn><accession-num>21695096</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=21695096</url></related-urls></urls><electronic-resource-num>10.4137/BCBCR.S6957&#xD;bcbcr-1-2011-117 [pii]</electronic-resource-num><language>eng</language></record></Cite></EndNote>[HYPERLINK \l "_ENREF_31" \o "Ayala-Feliciano, 2011 #2457"31]. These studies support the connection between rodents and human in neurocognitive response to chemotherapeutics and usefulness of pre-clinical research to provide information on the potential long-term neurocognitive side effects other treatment regiments.
With advances in technology and increases in environmental factors, more individuals diagnosed with cancer are under 50 years of age. These patients tend to have received more intense treatment to prevent recurrence, a condition that appears to correlate with higher rates of reported cognitive effect after chemotherapy  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_2" \o "Myers, 2010 #1871"2, HYPERLINK \l "_ENREF_32" \o "Baker, 2005 #107"32, HYPERLINK \l "_ENREF_33" \o "Hodgson, 2013 #2916"33]. Particularly in young individuals, even slight cognitive effects can negatively impact daily functioning related to work and child rearing  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_22" \o "Janelsins, 2011 #2315"22, HYPERLINK \l "_ENREF_34" \o "Wefel, 2004 #1574"34, HYPERLINK \l "_ENREF_35" \o "Reid-Arndt, 2009 #2383"35]. Consistently, the evidence is clear that some patients will display neurocognitive decline post-chemotherapy. Even with the existing evidence which sustain the relation about chemotherapy and cognitive impairment, many patients are not educated about the possibility of reduction in memory due to chemotherapy through pharmacotherapy  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_36" \o "Acevedo, 2012 #2671"36, HYPERLINK \l "_ENREF_37" \o "Acevedo, 2012 #2829"37]. Truly more emphasis needs to be placed on educating the patients on the potential risk of cognitive decline and the steps that can be taken to prevent or reduce the occurrence post-treatment.
	Rarely are patients only taking chemotherapeutic agents; they are generally put on medications to reduce side effects and to treat secondary conditions. For women with estrogen positive breast cancer the most common secondary medication is the estrogen receptor modulator (SERM), Tamoxifen. Tamoxifen is a pure estrogen receptor blocker, and along with its metabolites can cross the blood brain barrier modulating estrogen response in various brain regions including the hippocampus and amygdala  ADDIN EN.CITE <EndNote><Cite><Author>Ciocca</Author><Year>1995</Year><RecNum>2392</RecNum><DisplayText>[38]</DisplayText><record><rec-number>2392</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2392</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ciocca, D. R.</author><author>Roig, L. M.</author></authors></contributors><auth-address>Laboratory of Reproduction and Lactation, Regional Center for Scientific and Technological Research, Mendoza, Argentina.</auth-address><titles><title>Estrogen receptors in human nontarget tissues: biological and clinical implications</title><secondary-title>Endocr Rev</secondary-title></titles><periodical><full-title>Endocr Rev</full-title></periodical><pages>35-62</pages><volume>16</volume><number>1</number><edition>1995/02/01</edition><keywords><keyword>Animals</keyword><keyword>Central Nervous System/physiology</keyword><keyword>Digestive System Physiological Phenomena</keyword><keyword>Endocrine Glands/physiology</keyword><keyword>Female</keyword><keyword>Gene Expression Regulation/physiology</keyword><keyword>Genitalia, Male/physiology</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Organ Specificity/physiology</keyword><keyword>Receptors, Estrogen/*physiology</keyword></keywords><dates><year>1995</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>0163-769X (Print)&#xD;0163-769X (Linking)</isbn><accession-num>7758432</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=7758432</url></related-urls></urls><language>eng</language></record></Cite></EndNote>[HYPERLINK \l "_ENREF_38" \o "Ciocca, 1995 #2392"38]. Animal models using repeated tamoxifen or combinations of methotrexate and 5-FU injections have produced deficits in acquisition and retention in an operant learning paradigm (reviewed in  ADDIN EN.CITE <EndNote><Cite><Author>Acevedo</Author><Year>2012</Year><RecNum>2671</RecNum><DisplayText>[36]</DisplayText><record><rec-number>2671</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2671</key></foreign-keys><ref-type name="Book Section">5</ref-type><contributors><authors><author>Acevedo, S. F.</author></authors><secondary-authors><author>Kostner, G.</author><author>Frank, S.</author></secondary-authors></contributors><titles><title>The confounding factor of Apolipoprotein E on response to chemotherapy and hormone regulation altering long-term cognition outcomes</title><secondary-title>Lipoproteins - Role in Health and Diseases</secondary-title></titles><section>10</section><dates><year>2012</year></dates><pub-location>Rijeka, Croatia</pub-location><publisher>InTech </publisher><urls></urls></record></Cite></EndNote>[HYPERLINK \l "_ENREF_36" \o "Acevedo, 2012 #2671"36]). Similarly, clinical studies suggest that tamoxifen has a synergetic effect with chemotherapy to intensify the cognitive impairments, particularly in visual memory and visuospatial ability  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_36" \o "Acevedo, 2012 #2671"36, HYPERLINK \l "_ENREF_39" \o "Schilder, 2010 #2374"39]. Therefore, when tamoxifen is a necessary part of a chemotherapy regiment the increased risk of neurocognitive decline is expected, increasing the potential need for pharmacotherapy. Several alternatives to tamoxifen for estrogen receptor modulators are currently being tested in clinical trials, many of which are less detrimental with respect to cognition (reviewed in  ADDIN EN.CITE <EndNote><Cite><Author>Acevedo</Author><Year>2012</Year><RecNum>2671</RecNum><DisplayText>[36]</DisplayText><record><rec-number>2671</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2671</key></foreign-keys><ref-type name="Book Section">5</ref-type><contributors><authors><author>Acevedo, S. F.</author></authors><secondary-authors><author>Kostner, G.</author><author>Frank, S.</author></secondary-authors></contributors><titles><title>The confounding factor of Apolipoprotein E on response to chemotherapy and hormone regulation altering long-term cognition outcomes</title><secondary-title>Lipoproteins - Role in Health and Diseases</secondary-title></titles><section>10</section><dates><year>2012</year></dates><pub-location>Rijeka, Croatia</pub-location><publisher>InTech </publisher><urls></urls></record></Cite></EndNote>[HYPERLINK \l "_ENREF_36" \o "Acevedo, 2012 #2671"36]).

ApoE genotype and cancer 
	Why are some cancer patients affected strongly and others not at all? One possible explanation for the variability and range of cognitive side effects may rest in a person�s genetics. One candidate gene that appears to be both a risk factor for early on-set breast cancer  ADDIN EN.CITE <EndNote><Cite><Author>Porrata-Doria</Author><Year>2010</Year><RecNum>2461</RecNum><DisplayText>[40]</DisplayText><record><rec-number>2461</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2461</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Porrata-Doria, T.</author><author>Matta, J. L.</author><author>Acevedo, S. F.</author></authors></contributors><auth-address>Department of Physiology, Pharmacology, and Toxicology.</auth-address><titles><title>Apolipoprotein E allelic frequency altered in women with early-onset breast cancer</title><secondary-title>Breast Cancer (Auckl)</secondary-title><alt-title>Breast Cancer: Basic and Clinical Research</alt-title></titles><periodical><full-title>Breast Cancer (Auckl)</full-title></periodical><alt-periodical><full-title>Breast Cancer: Basic and Clinical Research</full-title></alt-periodical><pages>43-8</pages><volume>4</volume><edition>2010/08/11</edition><dates><year>2010</year></dates><isbn>1178-2234 (Electronic)&#xD;1178-2234 (Linking)</isbn><accession-num>20697532</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=20697532</url></related-urls></urls><language>eng</language></record></Cite></EndNote>[HYPERLINK \l "_ENREF_40" \o "Porrata-Doria, 2010 #2461"40] and that leads to heightened sensitivity to neuronal trauma  ADDIN EN.CITE <EndNote><Cite><Author>Mahley</Author><Year>2009</Year><RecNum>1803</RecNum><DisplayText>[41]</DisplayText><record><rec-number>1803</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">1803</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Mahley, R. W.</author><author>Weisgraber, K. H.</author><author>Huang, Y.</author></authors></contributors><auth-address>Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA. rmahley@gladstone.ucsf.edu</auth-address><titles><title>Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer&apos;s disease to AIDS</title><secondary-title>J Lipid Res</secondary-title></titles><periodical><full-title>J Lipid Res</full-title></periodical><pages>S183-8</pages><volume>50 Suppl</volume><edition>2008/12/25</edition><keywords><keyword>Acquired Immunodeficiency Syndrome/genetics/ metabolism</keyword><keyword>Alzheimer Disease/genetics/ metabolism</keyword><keyword>Animals</keyword><keyword>Apolipoproteins E/ chemistry/genetics/immunology/ metabolism</keyword><keyword>Atherosclerosis/genetics/ metabolism</keyword><keyword>Humans</keyword><keyword>Protein Binding</keyword></keywords><dates><year>2009</year><pub-dates><date>Apr</date></pub-dates></dates><isbn>0022-2275 (Print)&#xD;0022-2275 (Linking)</isbn><accession-num>19106071</accession-num><urls></urls><electronic-resource-num>R800069-JLR200 [pii]&#xD;10.1194/jlr.R800069-JLR200 [doi]</electronic-resource-num><language>eng</language></record></Cite></EndNote>[HYPERLINK \l "_ENREF_41" \o "Mahley, 2009 #1803"41] is Apolipoprotein or Apoprotein E (ApoE). The ApoE gene family of proteins is highly enriched in the brain  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_42" \o "Mahley, 2006 #2194"42, HYPERLINK \l "_ENREF_43" \o "Mahley, 2000 #2188"43] and plays a role in the metabolism and redistribution of lipoproteins and cholesterol  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_42" \o "Mahley, 2006 #2194"42-44]. In humans, there are three common alleles of ApoE (ApoE2, ApoE3, ApoE4)  ADDIN EN.CITE <EndNote><Cite><Author>Mahley</Author><Year>1988</Year><RecNum>893</RecNum><DisplayText>[45]</DisplayText><record><rec-number>893</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">893</key><key app="ENWeb" db-id="TWVFEgrtqgcAAHXhYvY">292</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Mahley, R.W.</author></authors></contributors><auth-address>Gladstone Foundation Laboratories for Cardiovascular Disease, University of California, San Francisco 94140-0608.</auth-address><titles><title>Apolipoprotein E: cholesterol transport protein with expanding role in cell biology</title><secondary-title>Science</secondary-title><alt-title>Science (New York, N.Y</alt-title></titles><periodical><full-title>Science</full-title></periodical><alt-periodical><full-title>Science</full-title><abbr-1>Science (New York, N.Y</abbr-1></alt-periodical><pages>622-30</pages><volume>240</volume><number>4852</number><keywords><keyword>Amino Acid Sequence</keyword><keyword>Apolipoproteins E/genetics/*physiology</keyword><keyword>Biological Transport</keyword><keyword>Cholesterol/*metabolism</keyword><keyword>Gene Expression Regulation</keyword><keyword>Humans</keyword><keyword>Hyperlipoproteinemia Type III/genetics/metabolism</keyword><keyword>Immunity</keyword><keyword>Lipid Metabolism</keyword><keyword>Molecular Sequence Data</keyword><keyword>Polymorphism, Genetic</keyword><keyword>Protein Conformation</keyword><keyword>Receptors, LDL/metabolism</keyword></keywords><dates><year>1988</year><pub-dates><date>Apr 29</date></pub-dates></dates><isbn>0036-8075 (Print)</isbn><accession-num>3283935</accession-num><urls></urls><language>eng</language></record></Cite></EndNote>[HYPERLINK \l "_ENREF_45" \o "Mahley, 1988 #893"45]. In rodent models, the lack of ApoE or express of human ApoE4 protein indicates there is destabilization of cell membranes and increased apoptosis in the hippocampus and cortex  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_41" \o "Mahley, 2009 #1803"41, HYPERLINK \l "_ENREF_46" \o "Struble, 2008 #2391"46]. In addition, those lacking ApoE or the expressing of human ApoE4 protein display impaired spatial learning and memory that increases with age  ADDIN EN.CITE <EndNote><Cite><Author>Raber</Author><Year>2008</Year><RecNum>1166</RecNum><DisplayText>[47]</DisplayText><record><rec-number>1166</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">1166</key><key app="ENWeb" db-id="TWVFEgrtqgcAAHXhYvY">1207</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Raber, J.</author></authors></contributors><auth-address>Department of Behavioral Neuroscience, Division of Neuroscience, ONPRC, Oregon Health &amp; Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. raberj@ohsu.edu</auth-address><titles><title>AR, apoE, and cognitive function</title><secondary-title>Horm Behav</secondary-title></titles><periodical><full-title>Horm Behav</full-title><abbr-1>Hormones and behavior</abbr-1></periodical><pages>706-15</pages><volume>53</volume><number>5</number><edition>2008/04/09</edition><keywords><keyword>Aged</keyword><keyword>Aging/physiology</keyword><keyword>Alzheimer Disease/genetics/physiopathology</keyword><keyword>Androgens/pharmacology/*physiology/therapeutic use</keyword><keyword>Apolipoproteins E/*physiology</keyword><keyword>Cognition/drug effects/*physiology</keyword><keyword>Cognition Disorders/genetics/physiopathology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Receptors, Androgen/*physiology</keyword><keyword>Risk Factors</keyword><keyword>Sex Characteristics</keyword><keyword>Testosterone/metabolism</keyword></keywords><dates><year>2008</year><pub-dates><date>May</date></pub-dates></dates><isbn>0018-506X (Print)</isbn><accession-num>18395206</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=18395206</url></related-urls></urls><electronic-resource-num>S0018-506X(08)00055-X [pii]&#xD;10.1016/j.yhbeh.2008.02.012</electronic-resource-num><language>eng</language></record></Cite></EndNote>[HYPERLINK \l "_ENREF_47" \o "Raber, 2008 #1166"47]. Whereas, those mice that express human ApoE3 and ApoE2 proteins have enhanced healthy cell functioning and are protected from cell loss following neuronal insult  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_41" \o "Mahley, 2009 #1803"41, HYPERLINK \l "_ENREF_47" \o "Raber, 2008 #1166"47, HYPERLINK \l "_ENREF_48" \o "Villasana, 2006 #1529"48]. Consistent with rodent models, clinical studies indicate a reduction in spatial learning and memory in those who carry the ApoE4 allele  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_49" \o "Berteau-Pavy, 2007 #162"49].
	In addition, particularly in Caucasian female ApoE4 carriers there is an increased risk of age-related mild cognitive impairment (MCI), the development of Alzheimer�s disease (AD) and display of distinctly different imaging profiles associated with hippocampal atrophy  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_50" \o "Bu, 2009 #226"50-52]. African Americans, Caribbean and Mexican Hispanics women also display risk factors associated with the ApoE4 allele, such as lowered age of onset of sporadic AD and reduced memory performance in individuals 65 years and older  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_53" \o "Olarte, 2006 #1060"53-55]. Currently only one study has assessed ApoE4 carrier status as a potential genetic risk factor for chemotherapy related neurocognitive impairments. The study examined female breast or lymphoma survivors, and found that even after 8 years, ApoE4 carriers displayed more impairment as a result of chemotherapy, specifically in visual memory and spatial ability  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_56" \o "Ahles, 2003 #36"56]. Although ApoE genotype was not reported, another study does indicate that spatial memory is altered in post-chemotherapy female breast cancer survivors  ADDIN EN.CITE <EndNote><Cite><Author>Ayala-Feliciano</Author><Year>2011</Year><RecNum>2457</RecNum><DisplayText>[31]</DisplayText><record><rec-number>2457</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2457</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ayala-Feliciano, M.</author><author>Pons-Valerio, J. J.</author><author>Pons-Madera, J.</author><author>Acevedo, S. F.</author></authors></contributors><auth-address>Clinical Psychology Program.</auth-address><titles><title>The Relationship between Visuospatial Memory and Coping Strategies in Breast Cancer Survivors</title><secondary-title>Breast Cancer (Auckl)</secondary-title><alt-title>Breast Cancer: Basic and Clinical Research</alt-title></titles><periodical><full-title>Breast Cancer (Auckl)</full-title></periodical><alt-periodical><full-title>Breast Cancer: Basic and Clinical Research</full-title></alt-periodical><pages>117-30</pages><volume>5</volume><edition>2011/06/23</edition><dates><year>2011</year></dates><isbn>1178-2234 (Electronic)&#xD;1178-2234 (Linking)</isbn><accession-num>21695096</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=21695096</url></related-urls></urls><electronic-resource-num>10.4137/BCBCR.S6957&#xD;bcbcr-1-2011-117 [pii]</electronic-resource-num><language>eng</language></record></Cite></EndNote>[HYPERLINK \l "_ENREF_31" \o "Ayala-Feliciano, 2011 #2457"31] in a task known to be sensitive to genotypic effects of ApoE  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_49" \o "Berteau-Pavy, 2007 #162"49]. These studies support the idea that ApoE genotype is a confounding factor when examining post-chemotherapy neurocognitive decline. 
	Being an ApoE4 carrier and taking tamoxifen does appear to result in higher plasma triglyceride levels known to be a risk factor for cardiovascular events  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_57" \o "Chang, 2009 #282"57, HYPERLINK \l "_ENREF_58" \o "Liberopoulos, 2002 #846"58]. In contrast, non-ApoE4 carriers tend to respond positively to tamoxifen with a lower risk for cardiovascular complications  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_58" \o "Liberopoulos, 2002 #846"58]. Considering that both ApoE4 and tamoxifen treatment have a negative effect on cognition and that tamoxifen has an ApoE genotype dependent effect on lipid profiles, both should be considered confounding factors when designing a course of treatment. Several alternatives to tamoxifen for estrogen receptor modulators are currently being tested in clinical trials, many of which are less detrimental with respect to cognition and have less effect on the cardiovascular system (reviewed in  ADDIN EN.CITE <EndNote><Cite><Author>Acevedo</Author><Year>2012</Year><RecNum>2671</RecNum><DisplayText>[36]</DisplayText><record><rec-number>2671</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2671</key></foreign-keys><ref-type name="Book Section">5</ref-type><contributors><authors><author>Acevedo, S. F.</author></authors><secondary-authors><author>Kostner, G.</author><author>Frank, S.</author></secondary-authors></contributors><titles><title>The confounding factor of Apolipoprotein E on response to chemotherapy and hormone regulation altering long-term cognition outcomes</title><secondary-title>Lipoproteins - Role in Health and Diseases</secondary-title></titles><section>10</section><dates><year>2012</year></dates><pub-location>Rijeka, Croatia</pub-location><publisher>InTech </publisher><urls></urls></record></Cite></EndNote>[HYPERLINK \l "_ENREF_36" \o "Acevedo, 2012 #2671"36]).
	Some patients also require irradiation as part of the treatment procedure for cancer. Previously whole body irradiation was used leading to detrimental effects on cognitive status (reviewed in  ADDIN EN.CITE <EndNote><Cite><Author>Greene-Schloesser</Author><Year>2013</Year><RecNum>2917</RecNum><DisplayText>[59]</DisplayText><record><rec-number>2917</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2917</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Greene-Schloesser, D.</author><author>Moore, E.</author><author>Robbins, M. E.</author></authors></contributors><auth-address>Authors&apos; Affiliations: Departments of Radiation Oncology and Cancer Biology; and Brain Tumor Center of Excellence, Wake Forest School of Medicine, Winston-Salem, North Carolina.</auth-address><titles><title>Molecular Pathways: Radiation-Induced Cognitive Impairment</title><secondary-title>Clin Cancer Res</secondary-title><alt-title>Clinical Cancer Research</alt-title></titles><periodical><full-title>Clin Cancer Res</full-title></periodical><dates><year>2013</year><pub-dates><date>Mar 21</date></pub-dates></dates><isbn>1078-0432 (Electronic)&#xD;1078-0432 (Linking)</isbn><accession-num>23388505</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/23388505</url></related-urls></urls><electronic-resource-num>10.1158/1078-0432.CCR-11-2903</electronic-resource-num></record></Cite></EndNote>[HYPERLINK \l "_ENREF_59" \o "Greene-Schloesser, 2013 #2917"59]). More recently efforts are being made to use more localized irradiation particular in the case of breast and gynecological cancers reducing the risk of potential neuronal damage. However, there are still some cases that do require whole body irradiation and those patients need to be aware that the risk of neurocognitive impairments post-treatment is significantly higher (reviewed in  ADDIN EN.CITE <EndNote><Cite><Author>Greene-Schloesser</Author><Year>2013</Year><RecNum>2917</RecNum><DisplayText>[59]</DisplayText><record><rec-number>2917</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2917</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Greene-Schloesser, D.</author><author>Moore, E.</author><author>Robbins, M. E.</author></authors></contributors><auth-address>Authors&apos; Affiliations: Departments of Radiation Oncology and Cancer Biology; and Brain Tumor Center of Excellence, Wake Forest School of Medicine, Winston-Salem, North Carolina.</auth-address><titles><title>Molecular Pathways: Radiation-Induced Cognitive Impairment</title><secondary-title>Clin Cancer Res</secondary-title><alt-title>Clinical Cancer Research</alt-title></titles><periodical><full-title>Clin Cancer Res</full-title></periodical><dates><year>2013</year><pub-dates><date>Mar 21</date></pub-dates></dates><isbn>1078-0432 (Electronic)&#xD;1078-0432 (Linking)</isbn><accession-num>23388505</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/23388505</url></related-urls></urls><electronic-resource-num>10.1158/1078-0432.CCR-11-2903</electronic-resource-num></record></Cite></EndNote>[HYPERLINK \l "_ENREF_59" \o "Greene-Schloesser, 2013 #2917"59]). 
ApoE genotype has not been looked as a factor in breast cancer patients post-irradiation, but those treated with radiotherapy for low grade gliomas that carry the ApoE4 allele do display reduced verbal memory  ADDIN EN.CITE <EndNote><Cite><Author>Correa</Author><Year>2007</Year><RecNum>2919</RecNum><DisplayText>[60]</DisplayText><record><rec-number>2919</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2919</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Correa, D. D.</author><author>DeAngelis, L. M.</author><author>Shi, W.</author><author>Thaler, H. T.</author><author>Lin, M.</author><author>Abrey, L. E.</author></authors></contributors><auth-address>Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. corread@mskcc.org</auth-address><titles><title>Cognitive functions in low-grade gliomas: disease and treatment effects</title><secondary-title>J Neurooncol</secondary-title><alt-title>Journal of Neuro-oncology</alt-title></titles><periodical><full-title>J Neurooncol</full-title><abbr-1>Journal of neuro-oncology</abbr-1></periodical><alt-periodical><full-title>J Neurooncol</full-title><abbr-1>Journal of neuro-oncology</abbr-1></alt-periodical><pages>175-84</pages><volume>81</volume><number>2</number><keywords><keyword>Adult</keyword><keyword>Antineoplastic Agents/therapeutic use</keyword><keyword>Apolipoprotein E4/genetics</keyword><keyword>Brain Neoplasms/drug therapy/*physiopathology/radiotherapy</keyword><keyword>Cognition Disorders/*physiopathology</keyword><keyword>Epilepsy/etiology/therapy</keyword><keyword>Female</keyword><keyword>Glioma/drug therapy/*physiopathology/radiotherapy</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Neuropsychological Tests</keyword></keywords><dates><year>2007</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>0167-594X (Print)&#xD;0167-594X (Linking)</isbn><accession-num>16850104</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/16850104</url></related-urls></urls><electronic-resource-num>10.1007/s11060-006-9212-3</electronic-resource-num></record></Cite></EndNote>[HYPERLINK \l "_ENREF_60" \o "Correa, 2007 #2919"60]. In mouse models specifically females that express human ApoE4, the mice require more trials to learn a new task after irradiation  ADDIN EN.CITE <EndNote><Cite><Author>Villasana</Author><Year>2006</Year><RecNum>1529</RecNum><DisplayText>[48]</DisplayText><record><rec-number>1529</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">1529</key><key app="ENWeb" db-id="TWVFEgrtqgcAAHXhYvY">294</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Villasana, L.</author><author>Acevedo, S.</author><author>Poage, C.</author><author>Raber, J.</author></authors></contributors><auth-address>Department of Behavioral Neuroscience, ONPRC, Oregon Health &amp; Science University, Portland, Oregon 97239, USA.</auth-address><titles><title>Sex- and APOE isoform-dependent effects of radiation on cognitive function</title><secondary-title>Radiat Res</secondary-title><alt-title>Radiation research</alt-title></titles><periodical><full-title>Radiat Res</full-title></periodical><pages>883-91</pages><volume>166</volume><number>6</number><keywords><keyword>Animals</keyword><keyword>Apolipoproteins E/*metabolism</keyword><keyword>Behavior, Animal/*physiology/*radiation effects</keyword><keyword>Cognition/*physiology/*radiation effects</keyword><keyword>Female</keyword><keyword>Male</keyword><keyword>Maze Learning/*physiology/*radiation effects</keyword><keyword>Mice</keyword><keyword>Mice, Inbred C57BL</keyword><keyword>Protein Isoforms/metabolism</keyword><keyword>Sex Factors</keyword></keywords><dates><year>2006</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>0033-7587 (Print)</isbn><accession-num>17149978</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=17149978</url></related-urls></urls><language>eng</language></record></Cite></EndNote>[HYPERLINK \l "_ENREF_48" \o "Villasana, 2006 #1529"48]. Those mice that expressed human ApoE2 where protected from the detrimental effects of irradiation  ADDIN EN.CITE <EndNote><Cite><Author>Villasana</Author><Year>2006</Year><RecNum>1529</RecNum><DisplayText>[48]</DisplayText><record><rec-number>1529</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">1529</key><key app="ENWeb" db-id="TWVFEgrtqgcAAHXhYvY">294</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Villasana, L.</author><author>Acevedo, S.</author><author>Poage, C.</author><author>Raber, J.</author></authors></contributors><auth-address>Department of Behavioral Neuroscience, ONPRC, Oregon Health &amp; Science University, Portland, Oregon 97239, USA.</auth-address><titles><title>Sex- and APOE isoform-dependent effects of radiation on cognitive function</title><secondary-title>Radiat Res</secondary-title><alt-title>Radiation research</alt-title></titles><periodical><full-title>Radiat Res</full-title></periodical><pages>883-91</pages><volume>166</volume><number>6</number><keywords><keyword>Animals</keyword><keyword>Apolipoproteins E/*metabolism</keyword><keyword>Behavior, Animal/*physiology/*radiation effects</keyword><keyword>Cognition/*physiology/*radiation effects</keyword><keyword>Female</keyword><keyword>Male</keyword><keyword>Maze Learning/*physiology/*radiation effects</keyword><keyword>Mice</keyword><keyword>Mice, Inbred C57BL</keyword><keyword>Protein Isoforms/metabolism</keyword><keyword>Sex Factors</keyword></keywords><dates><year>2006</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>0033-7587 (Print)</isbn><accession-num>17149978</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=17149978</url></related-urls></urls><language>eng</language></record></Cite></EndNote>[HYPERLINK \l "_ENREF_48" \o "Villasana, 2006 #1529"48]. Suggesting that for those patients receiving whole body radiation being an ApoE4 carrier may increase their risk of long-term neurocognitive impairments while ApoE2 carriers are less likely to display post-chemotherapy cognitive impairments.

Donepezil 
	Pharmacotherapy is one of the emerging ideas that in combination with chemotherapy may reduce the likelihood of long-term cognitive effects. Donepezil is a cholinesterase inhibitor (ChEI) that works to improve synaptic health and neurotransmission by reducing hydrolysis of acetylcholine (reviewed in  ADDIN EN.CITE <EndNote><Cite><Author>Kurz</Author><Year>2009</Year><RecNum>2824</RecNum><DisplayText>[61]</DisplayText><record><rec-number>2824</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2824</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kurz, A.</author><author>Farlow, M.</author><author>Lefevre, G.</author></authors></contributors><auth-address>Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany. alexander.kurz@lrz.tumuenchen.de</auth-address><titles><title>Pharmacokinetics of a novel transdermal rivastigmine patch for the treatment of Alzheimer&apos;s disease: a review</title><secondary-title>Int J Clin Pract</secondary-title></titles><periodical><full-title>Int J Clin Pract</full-title></periodical><pages>799-805</pages><volume>63</volume><number>5</number><edition>2009/04/28</edition><keywords><keyword>Administration, Cutaneous</keyword><keyword>Alzheimer Disease/*drug therapy</keyword><keyword>Biological Availability</keyword><keyword>Cholinesterase Inhibitors/administration &amp; dosage/*pharmacokinetics</keyword><keyword>Humans</keyword><keyword>Phenylcarbamates/administration &amp; dosage/*pharmacokinetics</keyword><keyword>Treatment Outcome</keyword></keywords><dates><year>2009</year><pub-dates><date>May</date></pub-dates></dates><isbn>1742-1241 (Electronic)&#xD;1368-5031 (Linking)</isbn><accession-num>19392927</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=19392927</url></related-urls></urls><electronic-resource-num>IJCP2052 [pii]&#xD;10.1111/j.1742-1241.2009.02052.x</electronic-resource-num><language>eng</language></record></Cite></EndNote>[HYPERLINK \l "_ENREF_61" \o "Kurz, 2009 #2824"61]). Donepezil is approved for treatment of early stage AD by the United States Food and Drug Administration (USFDA) and is available as either an oral medication or transdermal patch  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_61" \o "Kurz, 2009 #2824"61, HYPERLINK \l "_ENREF_62" \o "Sozio, 2012 #2815"62]. Oral medications are less tolerated and lead to gastric complications; therefore, the use of the transdermal patch is preferred to allow a delayed release and more stable administration of the medication  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_61" \o "Kurz, 2009 #2824"61, HYPERLINK \l "_ENREF_62" \o "Sozio, 2012 #2815"62]. Donepezil, in addition to its positive effects in reducing cognitive impairments in early AD, appears to improve cognitive health of both female and male patients surviving traumatic brain injury  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_63" \o "Zhang, 2004 #2820"63] as well as patients with brain tumors  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_64" \o "Shaw, 2006 #2821"64]. 
Rodent studies indicate a positive response to donepezil treatment after lesions  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_65" \o "Meunier, 2006 #2822"65] and in normal aging  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_66" \o "Hernandez, 2006 #2823"66], particularly in spatial memory task previously shown to be sensitive to the effects of chemotherapy (reviewed in  ADDIN EN.CITE <EndNote><Cite><Author>Acevedo</Author><Year>2012</Year><RecNum>2829</RecNum><DisplayText>[37]</DisplayText><record><rec-number>2829</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2829</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Acevedo, S. F.</author></authors></contributors><auth-address>Department of Physiology, Pharmacology, and Toxicology, Psychology Program, Ponce School of Medicine and Health Sciences, Ponce, Puerto Rico.</auth-address><titles><title>Why, After Chemotherapy, is it Necessary to Assess Memory Using Translational Testing?</title><secondary-title>Breast Cancer (Auckl)</secondary-title><alt-title>Breast Cancer: Basic and Clinical Research</alt-title></titles><periodical><full-title>Breast Cancer (Auckl)</full-title></periodical><alt-periodical><full-title>Breast Cancer: Basic and Clinical Research</full-title></alt-periodical><pages>181-90</pages><volume>6</volume><edition>2012/12/12</edition><dates><year>2012</year></dates><isbn>1178-2234 (Electronic)&#xD;1178-2234 (Linking)</isbn><accession-num>23226022</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=23226022</url></related-urls></urls><electronic-resource-num>10.4137/BCBCR.S10293&#xD;bcbcr-6-2012-181 [pii]</electronic-resource-num><language>eng</language></record></Cite></EndNote>[HYPERLINK \l "_ENREF_37" \o "Acevedo, 2012 #2829"37]). Using mouse models Winocur et al., (2011), co-injected donepezil with chemotherapeutic agents (MTX and 5-FU), results indicated that in spatial and non-spatial tasks the combination of treatments prevented cognitive deficits induced by chemotherapeutic (MTX and 5-FU) treatment alone (Figure 1). Donepezil treatment alone did not affect tested cognitive performance  ADDIN EN.CITE <EndNote><Cite><Author>Winocur</Author><Year>2011</Year><RecNum>2295</RecNum><DisplayText>[67]</DisplayText><record><rec-number>2295</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2295</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Winocur, G.</author><author>Binns, M. A.</author><author>Tannock, I.</author></authors></contributors><auth-address>Rotman Research Institute, Baycrest Centre, 3560 Bathurst Street, Toronto, ON M6A 2E1, Canada. gwinocur@rotman-baycrest.on.ca</auth-address><titles><title>Donepezil reduces cognitive impairment associated with anti-cancer drugs in a mouse model</title><secondary-title>Neuropharmacology</secondary-title><alt-title>Neuropharmacology</alt-title></titles><periodical><full-title>Neuropharmacology</full-title><abbr-1>Neuropharmacology</abbr-1></periodical><alt-periodical><full-title>Neuropharmacology</full-title><abbr-1>Neuropharmacology</abbr-1></alt-periodical><pages>1222-8</pages><volume>61</volume><number>8</number><edition>2011/08/02</edition><dates><year>2011</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>1873-7064 (Electronic)&#xD;0028-3908 (Linking)</isbn><accession-num>21803055</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=21803055</url></related-urls></urls><electronic-resource-num>S0028-3908(11)00289-9 [pii]&#xD;10.1016/j.neuropharm.2011.07.013</electronic-resource-num><language>eng</language></record></Cite></EndNote>[HYPERLINK \l "_ENREF_67" \o "Winocur, 2011 #2295"67]. Overall, animal studies suggest that donepezil is a potential pharmacotherapy which may be useful to prevent cognitive impairments in patients undergoing chemotherapy treatment.
	Currently donepezil has not been reportedly used by cancer patients as a potential pharmacotherapy for neurocognitive decline despite its positive pre-clinical results. It has been examined with respect to improvement of fatigue in older cancer survivors with no effect seen  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_68" \o "Bruera, 2007 #2825"68], the genetics of the patients were not examined. Increased fatigue is a common side-effect of chemotherapy treatment, is more common in women and is considered one of the predictors of self-reported memory problems among patients  ADDIN EN.CITE <EndNote><Cite><Author>Myers</Author><Year>2010</Year><RecNum>1871</RecNum><DisplayText>[2]</DisplayText><record><rec-number>1871</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">1871</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Myers, J. S.</author><author>Sousa, V. D.</author><author>Donovan, H. S.</author></authors></contributors><auth-address>School of Nursing, University of Kansas, Kansas City, USA. jamyers@swbell.net</auth-address><titles><title>Predictors of self-reported memory problems in patients with ovarian cancer who have received chemotherapy</title><secondary-title>Oncol Nurs Forum</secondary-title><alt-title>Oncology Nursing Forums</alt-title></titles><periodical><full-title>Oncol Nurs Forum</full-title><abbr-1>Oncology nursing forum</abbr-1></periodical><pages>596-603</pages><volume>37</volume><number>5</number><edition>2010/08/28</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Diagnostic Self Evaluation</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Memory Disorders/*epidemiology/nursing</keyword><keyword>Middle Aged</keyword><keyword>Nurse-Patient Relations</keyword><keyword>Ovarian Neoplasms/*drug therapy</keyword><keyword>Questionnaires</keyword><keyword>Severity of Illness Index</keyword><keyword>Young Adult</keyword></keywords><dates><year>2010</year><pub-dates><date>Sep 1</date></pub-dates></dates><isbn>1538-0688 (Electronic)&#xD;0190-535X (Linking)</isbn><accession-num>20797951</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=20797951</url></related-urls></urls><electronic-resource-num>R8470V36027L8484 [pii]&#xD;10.1188/10.ONF.596-603</electronic-resource-num><language>eng</language></record></Cite></EndNote>[HYPERLINK \l "_ENREF_2" \o "Myers, 2010 #1871"2]. To date only one study in elderly cancer patients has examined the relationship between ApoE genotype and fatigue, no associations were found  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_56" \o "Ahles, 2003 #36"56]. However, it has been shown that fatigue is more common in those who are ApoE4 carriers after other types of neuronal trauma  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_69" \o "Sundstrom, 2007 #2912"69]. We suggests that further studies would benefit from assessing pharamogenetic effects of ApoE genotype when examine efficacy of pharmacotherapy for fatigue.
Among AD patients, the ApoE4 carriers taking donepezil improved or had unchanged scores in visual and verbal memory tests, visual attention and the Mini Mental State Examination at the follow-up visits compared to those not on pharmacotherapeutic treatment (Figure 1)  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_70" \o "Bizzarro, 2005 #2335"70]. Magnetic resonance imaging (MRI) studies suggest a trend toward reduced hippocampal atrophy in mild cognitively impaired (MCI) patients who are ApoE4 carriers taking donepezil  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_71" \o "Jack, 2008 #2819"71]. Additional studies propose that ApoE4 carriers may be more responsive to this drug early in the progression of AD in terms of reducing the progression of neurocognitive decline (Figure 1)  ADDIN EN.CITE <EndNote><Cite><Author>Choi</Author><Year>2008</Year><RecNum>2818</RecNum><DisplayText>[72]</DisplayText><record><rec-number>2818</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2818</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Choi, S. H.</author><author>Kim, S. Y.</author><author>Na, H. R.</author><author>Kim, B. K.</author><author>Yang, D. W.</author><author>Kwon, J. C.</author><author>Park, M. Y.</author></authors></contributors><auth-address>Department of Neurology, Inha University College of Medicine, Incheon, South Korea.</auth-address><titles><title>Effect of ApoE genotype on response to donepezil in patients with Alzheimer&apos;s disease</title><secondary-title>Dement Geriatr Cogn Disord</secondary-title></titles><periodical><full-title>Dement Geriatr Cogn Disord</full-title></periodical><pages>445-50</pages><volume>25</volume><number>5</number><edition>2008/04/11</edition><keywords><keyword>Aged</keyword><keyword>Alzheimer Disease/*drug therapy/*genetics</keyword><keyword>Apolipoprotein E4/*genetics</keyword><keyword>Drug Resistance/genetics</keyword><keyword>Female</keyword><keyword>Follow-Up Studies</keyword><keyword>Genotype</keyword><keyword>Humans</keyword><keyword>Indans/*therapeutic use</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Nootropic Agents/*therapeutic use</keyword><keyword>Piperidines/*therapeutic use</keyword><keyword>Treatment Outcome</keyword></keywords><dates><year>2008</year></dates><isbn>1421-9824 (Electronic)&#xD;1420-8008 (Linking)</isbn><accession-num>18401173</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=18401173</url></related-urls></urls><electronic-resource-num>000124752 [pii]&#xD;10.1159/000124752</electronic-resource-num><language>eng</language></record></Cite></EndNote>[HYPERLINK \l "_ENREF_72" \o "Choi, 2008 #2818"72]. Therefore, if studies examine the potential use of donepezil as a potential pharmacotherapy for chemotherapy induced neurocongitive decline ApoE genotype should be considered a confounding factor when recommending this type of pharmacotherapy.

Fluoxetine
	Another suggested pharmacotherapy for neurocognitive decline is fluoxetine, administered as an anti-depressant that is a member of the selective serotonin reuptake inhibitors (SSRIs). Rodent and human studies suggest that fluoxetine increases cell proliferation in the hippocampus  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_73" \o "Lyons, 2012 #2327"73-75] and improves memory in those with impairments  ADDIN EN.CITE <EndNote><Cite><Author>Mowla</Author><Year>2007</Year><RecNum>2345</RecNum><DisplayText>[76]</DisplayText><record><rec-number>2345</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2345</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Mowla, A.</author><author>Mosavinasab, M.</author><author>Pani, A.</author></authors></contributors><auth-address>Department of Psychiatry, Shiraz University Medical Sciences, Shiraz, Iran. mowlaar@sums.ac.ir</auth-address><titles><title>Does fluoxetine have any effect on the cognition of patients with mild cognitive impairment? A double-blind, placebo-controlled, clinical trial</title><secondary-title>J Clin Psychopharmacol</secondary-title></titles><periodical><full-title>J Clin Psychopharmacol</full-title></periodical><pages>67-70</pages><volume>27</volume><number>1</number><edition>2007/01/17</edition><keywords><keyword>Aged</keyword><keyword>Cognition/*drug effects</keyword><keyword>Double-Blind Method</keyword><keyword>Female</keyword><keyword>Fluoxetine/*pharmacology/therapeutic use</keyword><keyword>Follow-Up Studies</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Memory/*drug effects</keyword><keyword>Memory Disorders/drug therapy/*psychology</keyword><keyword>Middle Aged</keyword><keyword>Psychological Tests</keyword><keyword>Serotonin Uptake Inhibitors/*pharmacology/therapeutic use</keyword></keywords><dates><year>2007</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>0271-0749 (Print)&#xD;0271-0749 (Linking)</isbn><accession-num>17224716</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=17224716</url></related-urls></urls><electronic-resource-num>10.1097/JCP.0b013e31802e0002&#xD;00004714-200702000-00013 [pii]</electronic-resource-num><language>eng</language></record></Cite></EndNote>[HYPERLINK \l "_ENREF_76" \o "Mowla, 2007 #2345"76]. In particular, fluoxetine when administered to rats before and during 5-FU or MXT chemotherapeutic drug treatment prevented spatial memory impairments and cellular effects in the hippocampus  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_73" \o "Lyons, 2012 #2327"73, HYPERLINK \l "_ENREF_77" \o "ElBeltagy, 2010 #2349"77, HYPERLINK \l "_ENREF_78" \o "Lyons, 2011 #2350"78]. Effects were not reversed with post-treatment, indicating it has to be given early throughout the course treatment  ADDIN EN.CITE <EndNote><Cite><Author>Lyons</Author><Year>2012</Year><RecNum>2327</RecNum><DisplayText>[73]</DisplayText><record><rec-number>2327</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2327</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lyons, L.</author><author>ElBeltagy, M.</author><author>Bennett, G.</author><author>Wigmore, P.</author></authors></contributors><auth-address>School of Biomedical Sciences, University of Nottingham, Nottingham, United Kingdom.</auth-address><titles><title>Fluoxetine counteracts the cognitive and cellular effects of 5-fluorouracil in the rat hippocampus by a mechanism of prevention rather than recovery</title><secondary-title>PLoS One</secondary-title></titles><periodical><full-title>PLoS One</full-title></periodical><pages>e30010</pages><volume>7</volume><number>1</number><edition>2012/01/25</edition><dates><year>2012</year></dates><isbn>1932-6203 (Electronic)&#xD;1932-6203 (Linking)</isbn><accession-num>22272269</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=22272269</url></related-urls></urls><electronic-resource-num>10.1371/journal.pone.0030010&#xD;PONE-D-11-09364 [pii]</electronic-resource-num><language>eng</language></record></Cite></EndNote>[HYPERLINK \l "_ENREF_73" \o "Lyons, 2012 #2327"73]. Increases in neurogenesis in the hippocampus and neuroprotection from microglia-mediated neurotoxicity also are seen rodents treated with fluoxetine  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_74" \o "Marcussen, 2008 #2342"74, HYPERLINK \l "_ENREF_75" \o "Zhang, 2012 #2802"75]. This supports the deduction that fluoxetine, in combination with chemotherapy, are likely to prevent neurocognitive effects.
	Fluoxetine appears to help overcome multi-drug resistance in breast cancer cells in combination with adriamycin or paclitaxel  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_79" \o "Zhou, 2012 #2801"79]. The effects were cell and drug combination specific and lead to a reduction in cell apoptosis signaling molecules  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_79" \o "Zhou, 2012 #2801"79]. In rats, fluoxetine treatment of carcinogenic colon tissue effectively prevents the development of colon cancer cells by reducing the number of lesions that occur  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_80" \o "Kannen, 2011 #2805"80, HYPERLINK \l "_ENREF_81" \o "Kannen, 2012 #2806"81]. The fluoxetine effectiveness in inhibiting tumor growth and enhancing apoptosis is dependent on cell type and stage  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_80" \o "Kannen, 2011 #2805"80, HYPERLINK \l "_ENREF_82" \o "Frick, 2008 #2828"82]. In the immune system, fluoxetine appears to enhance T-cell proliferation and T(H)1 cytokine production in a chronic stress model  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_83" \o "Frick, 2009 #2827"83]. Supporting that fluoxetine is beneficial in reducing tumorigenesis and boosting the immune system. 
	Other drug interactions have to be taken into consideration. It is not recommended that those women taking tamoxifen, also take fluoxetine due to inhibition of cytochrome 450 (CYP 450) isoforms 2D6, 2C19 and 2C9 (reviewed in  ADDIN EN.CITE <EndNote><Cite><Author>Miguel</Author><Year>2011</Year><RecNum>2813</RecNum><DisplayText>[84]</DisplayText><record><rec-number>2813</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2813</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Miguel, C.</author><author>Albuquerque, E.</author></authors></contributors><auth-address>Psychiatry Service of Hospitals of the University of Coimbra, Coimbra, Portugal. miguel_fernanda@yahoo.com</auth-address><titles><title>Drug interaction in psycho-oncology: antidepressants and antineoplastics</title><secondary-title>Pharmacology</secondary-title><alt-title>Pharmacology</alt-title></titles><periodical><full-title>Pharmacology</full-title></periodical><alt-periodical><full-title>Pharmacology</full-title></alt-periodical><pages>333-9</pages><volume>88</volume><number>5-6</number><edition>2011/11/30</edition><keywords><keyword>Animals</keyword><keyword>Antidepressive Agents/*therapeutic use</keyword><keyword>Antineoplastic Agents/*therapeutic use</keyword><keyword>Cytochrome P-450 Enzyme System/*antagonists &amp; inhibitors/metabolism</keyword><keyword>Depressive Disorder/drug therapy/metabolism</keyword><keyword>Drug Interactions</keyword><keyword>Humans</keyword><keyword>Neoplasms/drug therapy/metabolism</keyword></keywords><dates><year>2011</year></dates><isbn>1423-0313 (Electronic)&#xD;0031-7012 (Linking)</isbn><accession-num>22123153</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=22123153</url></related-urls></urls><electronic-resource-num>000334738 [pii]&#xD;10.1159/000334738</electronic-resource-num><language>eng</language></record></Cite></EndNote>[HYPERLINK \l "_ENREF_84" \o "Miguel, 2011 #2813"84]) by both medications. Inhibition of CYP 450 isoforms (responsible for metabolism of most medications) leads to changes in drug metabolism and increases potential side effects  ADDIN EN.CITE <EndNote><Cite><Author>Miguel</Author><Year>2011</Year><RecNum>2813</RecNum><DisplayText>[84]</DisplayText><record><rec-number>2813</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2813</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Miguel, C.</author><author>Albuquerque, E.</author></authors></contributors><auth-address>Psychiatry Service of Hospitals of the University of Coimbra, Coimbra, Portugal. miguel_fernanda@yahoo.com</auth-address><titles><title>Drug interaction in psycho-oncology: antidepressants and antineoplastics</title><secondary-title>Pharmacology</secondary-title><alt-title>Pharmacology</alt-title></titles><periodical><full-title>Pharmacology</full-title></periodical><alt-periodical><full-title>Pharmacology</full-title></alt-periodical><pages>333-9</pages><volume>88</volume><number>5-6</number><edition>2011/11/30</edition><keywords><keyword>Animals</keyword><keyword>Antidepressive Agents/*therapeutic use</keyword><keyword>Antineoplastic Agents/*therapeutic use</keyword><keyword>Cytochrome P-450 Enzyme System/*antagonists &amp; inhibitors/metabolism</keyword><keyword>Depressive Disorder/drug therapy/metabolism</keyword><keyword>Drug Interactions</keyword><keyword>Humans</keyword><keyword>Neoplasms/drug therapy/metabolism</keyword></keywords><dates><year>2011</year></dates><isbn>1423-0313 (Electronic)&#xD;0031-7012 (Linking)</isbn><accession-num>22123153</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=22123153</url></related-urls></urls><electronic-resource-num>000334738 [pii]&#xD;10.1159/000334738</electronic-resource-num><language>eng</language></record></Cite></EndNote>[HYPERLINK \l "_ENREF_84" \o "Miguel, 2011 #2813"84]. It is important to take these drug-drug interactions into consideration concomitant with an individual�s physiological status (age, gender, and other conditions) and genetic polymorphism. Such factors as ApoE genotype shown to alter drug-efficiency (reviewed in  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_36" \o "Acevedo, 2012 #2671"36, HYPERLINK \l "_ENREF_85" \o "Scripture, 2006 #2826"85]).
	To date, associations between fluoxetine and ApoE in clinical studies have not been reported. However, mice lacking ApoE have fewer serotonergic projections and their pathways between neuron terminals and cell bodies are altered  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_86" \o "Chapman, 1998 #2382"86]. In response to this type of pharmacotherapy, considerations that with expression of ApoE3 vs. ApoE4 alters neuronal functioning, examination of ApoE genotype is suggested. Studies do indicate that dementia patients taking other anti-psychotics whom are ApoE4 carriers do display increased agitation  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_87" \o "Proitsi, 2012 #2951"87]. In addition, cognitively intact ApoE4 carriers taking other SSRIs including paroxetine for depression response slower to the effects of the drug compared non-carriers  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_88" \o "Murphy, 2003 #2353"88]. In contrast to those taking mirtazapine, a noradrenergic and specific serotonergic agent used to increase serotonin, were ApoE4 carriers response more quickly to the effects of the medication compared to non-carriers  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_88" \o "Murphy, 2003 #2353"88]. This suggests that ApoE genotype is a confounding factor in the pharmacological response (Figure 1).
One must also consider the side effects associated with the SSRI medications, such as weight gain, higher cholesterol, higher triglycerides, and higher low-density lipoprotein levels, which are seen in patients after treatment  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_89" \o "Tamayo, 2009 #2351"89]. There appears to be a potential risk of obesity and hypercholesterolemia with this class of medications particularly in those that have an ApoE2 allele for those taking SSRIs (Figure 1)  ADDIN EN.CITE  ADDIN EN.CITE.DATA [HYPERLINK \l "_ENREF_90" \o "Raeder, 2006 #2352"90]. All of these factors are related to ApoE genotype suggesting that pharmacogenetic interactions warrant further studies in both animal and clinical settings.

Conclusion	
	Until chemotherapeutic agents can be identified that do not have neuronal side-effects, more research is needed on the usefulness of preventative pharmacotherapy. Awareness of the potential of particular pharmacotherapy, drug-drug interactions, and genetic factors can help clinicians make appropriate recommendations to their patients that produce best possible course of treatment and long-term outcomes for the functioning of their body and mind. 


Acknowledgements
Special thanks go to Robert Ritchie from the PSMHS/RCMI Publications Office (G12 RR003050/8G12MD007579-27). References
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Figure 1. Diagram of the associations between ApoE genotype, donepezil and/or fluoxetine affecting chemotherapeutic induced neurocognitive decline. 










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Uhqp^JmHnHu**[+[,[��d�gd�h6&P1�h:p�2V��/ ��=!��"��#��$��%��������$D<EndNote><Cite><Author>Myers</Author><Year>2010</Year><RecNum>1871</RecNum><DisplayText>[2-6]</DisplayText><record><rec-number>1871</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">1871</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Myers, J. S.</author><author>Sousa, V. D.</author><author>Donovan, H. S.</author></authors></contributors><auth-address>School of Nursing, University of Kansas, Kansas City, USA. jamyers@swbell.net</auth-address><titles><title>Predictors of self-reported memory problems in patients with ovarian cancer who have received chemotherapy</title><secondary-title>Oncol Nurs Forum</secondary-title><alt-title>Oncology Nursing Forums</alt-title></titles><periodical><full-title>Oncol Nurs Forum</full-title><abbr-1>Oncology nursing forum</abbr-1></periodical><pages>596-603</pages><volume>37</volume><number>5</number><edition>2010/08/28</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Diagnostic Self Evaluation</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Memory Disorders/*epidemiology/nursing</keyword><keyword>Middle Aged</keyword><keyword>Nurse-Patient Relations</keyword><keyword>Ovarian Neoplasms/*drug therapy</keyword><keyword>Questionnaires</keyword><keyword>Severity of Illness Index</keyword><keyword>Young Adult</keyword></keywords><dates><year>2010</year><pub-dates><date>Sep 1</date></pub-dates></dates><isbn>1538-0688 (Electronic)&#xD;0190-535X (Linking)</isbn><accession-num>20797951</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=20797951</url></related-urls></urls><electronic-resource-num>R8470V36027L8484 [pii]&#xD;10.1188/10.ONF.596-603</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Ferguson</Author><Year>2007</Year><RecNum>470</RecNum><record><rec-number>470</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">470</key><key app="ENWeb" db-id="TWVFEgrtqgcAAHXhYvY">478</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ferguson, R.J.</author><author>McDonald, B.C.</author><author>Saykin, A.J.</author><author>Ahles, T.A.</author></authors></contributors><auth-address>Department of Rehabilitation Medicine, Eastern Maine Medical Center, Bangor, ME 04401, USA. rferguson@emh.org</auth-address><titles><title>Brain structure and function differences in monozygotic twins: possible effects of breast cancer chemotherapy.</title><secondary-title>J Clin Oncol</secondary-title></titles><periodical><full-title>J Clin Oncol</full-title></periodical><pages>3866-70</pages><volume>25</volume><number>25</number><keywords><keyword>Antineoplastic Combined Chemotherapy Protocols/*adverse effects</keyword><keyword>Apolipoproteins E</keyword><keyword>Brain/anatomy &amp; histology/pathology/*physiopathology</keyword><keyword>Breast Neoplasms/*drug therapy</keyword><keyword>Cognition Disorders/*chemically induced/diagnosis/*physiopathology</keyword><keyword>Cyclophosphamide/administration &amp; dosage</keyword><keyword>Doxorubicin/administration &amp; dosage</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Magnetic Resonance Imaging</keyword><keyword>Middle Aged</keyword><keyword>Neuropsychological Tests</keyword><keyword>Survivors</keyword><keyword>Tamoxifen/administration &amp; dosage</keyword><keyword>Twins, Monozygotic</keyword></keywords><dates><year>2007</year><pub-dates><date>Sep 1</date></pub-dates></dates><isbn>1527-7755 (Electronic)</isbn><accession-num>17761972</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=17761972</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Nelson</Author><Year>2007</Year><RecNum>1025</RecNum><record><rec-number>1025</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">1025</key><key app="ENWeb" db-id="TWVFEgrtqgcAAHXhYvY">471</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Nelson, C.J.</author><author>Nandy, N.</author><author>Roth, A.J.</author></authors></contributors><auth-address>Department of Psychiatry and Behavioral Sciences, Memorial Sloan-Kettering Cancer Center, New York, New York 10022, USA. nelsonc@mskcc.org</auth-address><titles><title>Chemotherapy and cognitive deficits: mechanisms, findings, and potential interventions</title><secondary-title>Palliat Support Care</secondary-title><alt-title>Palliative &amp; Supportive Care</alt-title></titles><periodical><full-title>Palliat Support Care</full-title><abbr-1>Palliative &amp; supportive care</abbr-1></periodical><alt-periodical><full-title>Palliat Support Care</full-title><abbr-1>Palliative &amp; supportive care</abbr-1></alt-periodical><pages>273-80</pages><volume>5</volume><number>3</number><keywords><keyword>Antineoplastic Agents/*adverse effects</keyword><keyword>Breast Neoplasms/complications/drug therapy</keyword><keyword>Cognition Disorders/*chemically induced/physiopathology/prevention &amp;</keyword><keyword>control</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Quality of Life</keyword></keywords><dates><year>2007</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>1478-9515 (Print)</isbn><accession-num>17969831</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=17969831</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Wigmore</Author><Year>2010</Year><RecNum>2348</RecNum><record><rec-number>2348</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2348</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wigmore, P. 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S.</author></authors></contributors><auth-address>School of Nursing, University of Kansas, Kansas City, USA. jamyers@swbell.net</auth-address><titles><title>Predictors of self-reported memory problems in patients with ovarian cancer who have received chemotherapy</title><secondary-title>Oncol Nurs Forum</secondary-title><alt-title>Oncology Nursing Forums</alt-title></titles><periodical><full-title>Oncol Nurs Forum</full-title><abbr-1>Oncology nursing forum</abbr-1></periodical><pages>596-603</pages><volume>37</volume><number>5</number><edition>2010/08/28</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Diagnostic Self Evaluation</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Memory Disorders/*epidemiology/nursing</keyword><keyword>Middle Aged</keyword><keyword>Nurse-Patient Relations</keyword><keyword>Ovarian Neoplasms/*drug therapy</keyword><keyword>Questionnaires</keyword><keyword>Severity of Illness Index</keyword><keyword>Young Adult</keyword></keywords><dates><year>2010</year><pub-dates><date>Sep 1</date></pub-dates></dates><isbn>1538-0688 (Electronic)&#xD;0190-535X (Linking)</isbn><accession-num>20797951</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=20797951</url></related-urls></urls><electronic-resource-num>R8470V36027L8484 [pii]&#xD;10.1188/10.ONF.596-603</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Hodgson</Author><Year>2013</Year><RecNum>2916</RecNum><record><rec-number>2916</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2916</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hodgson, K. D.</author><author>Hutchinson, A. D.</author><author>Wilson, C. J.</author><author>Nettelbeck, T.</author></authors></contributors><auth-address>School of Psychology, University of Adelaide, Adelaide, SA, Australia. kristy.hodgson@adelaide.edu.au</auth-address><titles><title>A meta-analysis of the effects of chemotherapy on cognition in patients with cancer</title><secondary-title>Cancer Treat Rev</secondary-title><alt-title>Cancer Treatment Reviews</alt-title></titles><periodical><full-title>Cancer Treat Rev</full-title></periodical><pages>297-304</pages><volume>39</volume><number>3</number><dates><year>2013</year><pub-dates><date>May</date></pub-dates></dates><isbn>1532-1967 (Electronic)&#xD;0305-7372 (Linking)</isbn><accession-num>23219452</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/23219452</url></related-urls></urls><electronic-resource-num>10.1016/j.ctrv.2012.11.001</electronic-resource-num></record></Cite></EndNote>^D<EndNote><Cite><Author>Baker</Author><Year>2005</Year><RecNum>107</RecNum><DisplayText>[2, 32, 33]</DisplayText><record><rec-number>107</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">107</key><key app="ENWeb" db-id="TWVFEgrtqgcAAHXhYvY">124</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Baker, F.</author><author>Denniston, M.</author><author>Smith, T.</author><author>West, M.M.</author></authors></contributors><auth-address>Behavioral Research Center, American Cancer Society, Atlanta, Georgia, USA. frankbaker2@comcast.net</auth-address><titles><title>Adult cancer survivors: how are they faring?</title><secondary-title>Cancer</secondary-title><alt-title>Cancer</alt-title></titles><periodical><full-title>Cancer</full-title><abbr-1>Cancer</abbr-1></periodical><alt-periodical><full-title>Cancer</full-title><abbr-1>Cancer</abbr-1></alt-periodical><pages>2565-76</pages><volume>104</volume><number>11 Suppl</number><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Age Factors</keyword><keyword>Demography</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Neoplasm Recurrence, Local/psychology</keyword><keyword>Neoplasms/complications/*psychology</keyword><keyword>Pilot Projects</keyword><keyword>Quality of Life/psychology</keyword><keyword>Sex Factors</keyword><keyword>Sexual Dysfunction, Physiological/etiology/psychology</keyword><keyword>Sleep Disorders/etiology/psychology</keyword><keyword>Survivors/*psychology</keyword></keywords><dates><year>2005</year><pub-dates><date>Dec 1</date></pub-dates></dates><isbn>0008-543X (Print)</isbn><accession-num>16258929</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16258929</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Myers</Author><Year>2010</Year><RecNum>1871</RecNum><record><rec-number>1871</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">1871</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Myers, J. S.</author><author>Sousa, V. D.</author><author>Donovan, H. S.</author></authors></contributors><auth-address>School of Nursing, University of Kansas, Kansas City, USA. jamyers@swbell.net</auth-address><titles><title>Predictors of self-reported memory problems in patients with ovarian cancer who have received chemotherapy</title><secondary-title>Oncol Nurs Forum</secondary-title><alt-title>Oncology Nursing Forums</alt-title></titles><periodical><full-title>Oncol Nurs Forum</full-title><abbr-1>Oncology nursing forum</abbr-1></periodical><pages>596-603</pages><volume>37</volume><number>5</number><edition>2010/08/28</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Diagnostic Self Evaluation</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Memory Disorders/*epidemiology/nursing</keyword><keyword>Middle Aged</keyword><keyword>Nurse-Patient Relations</keyword><keyword>Ovarian Neoplasms/*drug therapy</keyword><keyword>Questionnaires</keyword><keyword>Severity of Illness Index</keyword><keyword>Young Adult</keyword></keywords><dates><year>2010</year><pub-dates><date>Sep 1</date></pub-dates></dates><isbn>1538-0688 (Electronic)&#xD;0190-535X (Linking)</isbn><accession-num>20797951</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=20797951</url></related-urls></urls><electronic-resource-num>R8470V36027L8484 [pii]&#xD;10.1188/10.ONF.596-603</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Hodgson</Author><Year>2013</Year><RecNum>2916</RecNum><record><rec-number>2916</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2916</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hodgson, K. D.</author><author>Hutchinson, A. D.</author><author>Wilson, C. J.</author><author>Nettelbeck, T.</author></authors></contributors><auth-address>School of Psychology, University of Adelaide, Adelaide, SA, Australia. kristy.hodgson@adelaide.edu.au</auth-address><titles><title>A meta-analysis of the effects of chemotherapy on cognition in patients with cancer</title><secondary-title>Cancer Treat Rev</secondary-title><alt-title>Cancer Treatment Reviews</alt-title></titles><periodical><full-title>Cancer Treat Rev</full-title></periodical><pages>297-304</pages><volume>39</volume><number>3</number><dates><year>2013</year><pub-dates><date>May</date></pub-dates></dates><isbn>1532-1967 (Electronic)&#xD;0305-7372 (Linking)</isbn><accession-num>23219452</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/23219452</url></related-urls></urls><electronic-resource-num>10.1016/j.ctrv.2012.11.001</electronic-resource-num></record></Cite></EndNote>�D<EndNote><Cite><Author>Janelsins</Author><Year>2011</Year><RecNum>2315</RecNum><DisplayText>[22, 34, 35]</DisplayText><record><rec-number>2315</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2315</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Janelsins, M. C.</author><author>Kohli, S.</author><author>Mohile, S. G.</author><author>Usuki, K.</author><author>Ahles, T. A.</author><author>Morrow, G. R.</author></authors></contributors><auth-address>Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA. michelle_janelsins@urmc.rochester.edu</auth-address><titles><title>An update on cancer- and chemotherapy-related cognitive dysfunction: current status</title><secondary-title>Semin Oncol</secondary-title><alt-title>Seminars in Oncology </alt-title></titles><periodical><full-title>Semin Oncol</full-title></periodical><pages>431-8</pages><volume>38</volume><number>3</number><edition>2011/05/24</edition><keywords><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Antineoplastic Agents/*adverse effects</keyword><keyword>Antineoplastic Agents, Hormonal/adverse effects</keyword><keyword>Brain Neoplasms/complications/drug therapy</keyword><keyword>Breast Neoplasms/complications/drug therapy</keyword><keyword>Cognition Disorders/*chemically induced/diagnosis/physiopathology</keyword><keyword>Female</keyword><keyword>Geriatric Assessment</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Neoplasms/complications/*drug therapy</keyword><keyword>Prostatic Neoplasms/complications/drug therapy</keyword><keyword>Risk Factors</keyword></keywords><dates><year>2011</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>1532-8708 (Electronic)&#xD;0093-7754 (Linking)</isbn><accession-num>21600374</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=21600374</url></related-urls></urls><electronic-resource-num>S0093-7754(11)00084-4 [pii]&#xD;10.1053/j.seminoncol.2011.03.014</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Wefel</Author><Year>2004</Year><RecNum>1574</RecNum><record><rec-number>1574</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">1574</key><key app="ENWeb" db-id="TWVFEgrtqgcAAHXhYvY">748</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wefel, J.S.</author><author>Lenzi, R.</author><author>Theriault, R.L.</author><author>Davis, R.N.</author><author>Meyers, C.A.</author></authors></contributors><auth-address>Department of Neuro-Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.</auth-address><titles><title>The cognitive sequelae of standard-dose adjuvant chemotherapy in women with breast carcinoma: results of a prospective, randomized, longitudinal trial</title><secondary-title>Cancer</secondary-title><alt-title>Cancer</alt-title></titles><periodical><full-title>Cancer</full-title><abbr-1>Cancer</abbr-1></periodical><alt-periodical><full-title>Cancer</full-title><abbr-1>Cancer</abbr-1></alt-periodical><pages>2292-9</pages><volume>100</volume><number>11</number><keywords><keyword>Adult</keyword><keyword>Antineoplastic Combined Chemotherapy Protocols/*adverse effects</keyword><keyword>Breast Neoplasms/*drug therapy/*psychology</keyword><keyword>Chemotherapy, Adjuvant/*adverse effects</keyword><keyword>Cognition Disorders/*chemically induced/diagnosis</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Longitudinal Studies</keyword><keyword>Mastectomy</keyword><keyword>Middle Aged</keyword><keyword>Neoplasm Invasiveness/pathology</keyword><keyword>Neuropsychological Tests</keyword><keyword>Prospective Studies</keyword><keyword>Quality of Life</keyword></keywords><dates><year>2004</year><pub-dates><date>Jun 1</date></pub-dates></dates><isbn>0008-543X (Print)</isbn><accession-num>15160331</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=15160331</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Reid-Arndt</Author><Year>2009</Year><RecNum>2383</RecNum><record><rec-number>2383</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2383</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Reid-Arndt, S. A.</author><author>Yee, A.</author><author>Perry, M. C.</author><author>Hsieh, C.</author></authors></contributors><auth-address>Department of Health Psychology, University of Missouri, Columbia, MO 65212, USA. reidarndts@health.missouri.edu</auth-address><titles><title>Cognitive and psychological factors associated with early posttreatment functional outcomes in breast cancer survivors</title><secondary-title>J Psychosoc Oncol</secondary-title><alt-title>Journal of Psychosocial Oncology</alt-title></titles><periodical><full-title>J Psychosoc Oncol</full-title></periodical><alt-periodical><full-title>Journal of Psychosocial Oncology</full-title></alt-periodical><pages>415-34</pages><volume>27</volume><number>4</number><edition>2009/10/09</edition><keywords><keyword>Antineoplastic Agents/adverse effects</keyword><keyword>Breast Neoplasms/drug therapy/*psychology</keyword><keyword>Cognition Disorders/chemically induced</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Middle Aged</keyword><keyword>Neuropsychological Tests</keyword><keyword>Psychological Tests</keyword><keyword>Quality of Life/psychology</keyword><keyword>Social Adjustment</keyword><keyword>Social Support</keyword><keyword>Survival/*psychology</keyword><keyword>Treatment Outcome</keyword></keywords><dates><year>2009</year></dates><isbn>1540-7586 (Electronic)&#xD;0734-7332 (Linking)</isbn><accession-num>19813133</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=19813133</url></related-urls></urls><electronic-resource-num>915718662 [pii]&#xD;10.1080/07347330903183117</electronic-resource-num><language>eng</language></record></Cite></EndNote>�D<EndNote><Cite><Author>Janelsins</Author><Year>2011</Year><RecNum>2315</RecNum><DisplayText>[22, 34, 35]</DisplayText><record><rec-number>2315</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2315</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Janelsins, M. C.</author><author>Kohli, S.</author><author>Mohile, S. G.</author><author>Usuki, K.</author><author>Ahles, T. A.</author><author>Morrow, G. R.</author></authors></contributors><auth-address>Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA. michelle_janelsins@urmc.rochester.edu</auth-address><titles><title>An update on cancer- and chemotherapy-related cognitive dysfunction: current status</title><secondary-title>Semin Oncol</secondary-title><alt-title>Seminars in Oncology </alt-title></titles><periodical><full-title>Semin Oncol</full-title></periodical><pages>431-8</pages><volume>38</volume><number>3</number><edition>2011/05/24</edition><keywords><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Antineoplastic Agents/*adverse effects</keyword><keyword>Antineoplastic Agents, Hormonal/adverse effects</keyword><keyword>Brain Neoplasms/complications/drug therapy</keyword><keyword>Breast Neoplasms/complications/drug therapy</keyword><keyword>Cognition Disorders/*chemically induced/diagnosis/physiopathology</keyword><keyword>Female</keyword><keyword>Geriatric Assessment</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Neoplasms/complications/*drug therapy</keyword><keyword>Prostatic Neoplasms/complications/drug therapy</keyword><keyword>Risk Factors</keyword></keywords><dates><year>2011</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>1532-8708 (Electronic)&#xD;0093-7754 (Linking)</isbn><accession-num>21600374</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=21600374</url></related-urls></urls><electronic-resource-num>S0093-7754(11)00084-4 [pii]&#xD;10.1053/j.seminoncol.2011.03.014</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Wefel</Author><Year>2004</Year><RecNum>1574</RecNum><record><rec-number>1574</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">1574</key><key app="ENWeb" db-id="TWVFEgrtqgcAAHXhYvY">748</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wefel, J.S.</author><author>Lenzi, R.</author><author>Theriault, R.L.</author><author>Davis, R.N.</author><author>Meyers, C.A.</author></authors></contributors><auth-address>Department of Neuro-Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.</auth-address><titles><title>The cognitive sequelae of standard-dose adjuvant chemotherapy in women with breast carcinoma: results of a prospective, randomized, longitudinal trial</title><secondary-title>Cancer</secondary-title><alt-title>Cancer</alt-title></titles><periodical><full-title>Cancer</full-title><abbr-1>Cancer</abbr-1></periodical><alt-periodical><full-title>Cancer</full-title><abbr-1>Cancer</abbr-1></alt-periodical><pages>2292-9</pages><volume>100</volume><number>11</number><keywords><keyword>Adult</keyword><keyword>Antineoplastic Combined Chemotherapy Protocols/*adverse effects</keyword><keyword>Breast Neoplasms/*drug therapy/*psychology</keyword><keyword>Chemotherapy, Adjuvant/*adverse effects</keyword><keyword>Cognition Disorders/*chemically induced/diagnosis</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Longitudinal Studies</keyword><keyword>Mastectomy</keyword><keyword>Middle Aged</keyword><keyword>Neoplasm Invasiveness/pathology</keyword><keyword>Neuropsychological Tests</keyword><keyword>Prospective Studies</keyword><keyword>Quality of Life</keyword></keywords><dates><year>2004</year><pub-dates><date>Jun 1</date></pub-dates></dates><isbn>0008-543X (Print)</isbn><accession-num>15160331</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=15160331</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Reid-Arndt</Author><Year>2009</Year><RecNum>2383</RecNum><record><rec-number>2383</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2383</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Reid-Arndt, S. A.</author><author>Yee, A.</author><author>Perry, M. C.</author><author>Hsieh, C.</author></authors></contributors><auth-address>Department of Health Psychology, University of Missouri, Columbia, MO 65212, USA. reidarndts@health.missouri.edu</auth-address><titles><title>Cognitive and psychological factors associated with early posttreatment functional outcomes in breast cancer survivors</title><secondary-title>J Psychosoc Oncol</secondary-title><alt-title>Journal of Psychosocial Oncology</alt-title></titles><periodical><full-title>J Psychosoc Oncol</full-title></periodical><alt-periodical><full-title>Journal of Psychosocial Oncology</full-title></alt-periodical><pages>415-34</pages><volume>27</volume><number>4</number><edition>2009/10/09</edition><keywords><keyword>Antineoplastic Agents/adverse effects</keyword><keyword>Breast Neoplasms/drug therapy/*psychology</keyword><keyword>Cognition Disorders/chemically induced</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Middle Aged</keyword><keyword>Neuropsychological Tests</keyword><keyword>Psychological Tests</keyword><keyword>Quality of Life/psychology</keyword><keyword>Social Adjustment</keyword><keyword>Social Support</keyword><keyword>Survival/*psychology</keyword><keyword>Treatment Outcome</keyword></keywords><dates><year>2009</year></dates><isbn>1540-7586 (Electronic)&#xD;0734-7332 (Linking)</isbn><accession-num>19813133</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=19813133</url></related-urls></urls><electronic-resource-num>915718662 [pii]&#xD;10.1080/07347330903183117</electronic-resource-num><language>eng</language></record></Cite></EndNote>*	D<EndNote><Cite><Author>Acevedo</Author><Year>2012</Year><RecNum>2671</RecNum><DisplayText>[36, 37]</DisplayText><record><rec-number>2671</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2671</key></foreign-keys><ref-type name="Book Section">5</ref-type><contributors><authors><author>Acevedo, S. F.</author></authors><secondary-authors><author>Kostner, G.</author><author>Frank, S.</author></secondary-authors></contributors><titles><title>The confounding factor of Apolipoprotein E on response to chemotherapy and hormone regulation altering long-term cognition outcomes</title><secondary-title>Lipoproteins - Role in Health and Diseases</secondary-title></titles><section>10</section><dates><year>2012</year></dates><pub-location>Rijeka, Croatia</pub-location><publisher>InTech </publisher><urls></urls></record></Cite><Cite><Author>Acevedo</Author><Year>2012</Year><RecNum>2829</RecNum><record><rec-number>2829</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2829</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Acevedo, S. F.</author></authors></contributors><auth-address>Department of Physiology, Pharmacology, and Toxicology, Psychology Program, Ponce School of Medicine and Health Sciences, Ponce, Puerto Rico.</auth-address><titles><title>Why, After Chemotherapy, is it Necessary to Assess Memory Using Translational Testing?</title><secondary-title>Breast Cancer (Auckl)</secondary-title><alt-title>Breast Cancer: Basic and Clinical Research</alt-title></titles><periodical><full-title>Breast Cancer (Auckl)</full-title></periodical><alt-periodical><full-title>Breast Cancer: Basic and Clinical Research</full-title></alt-periodical><pages>181-90</pages><volume>6</volume><edition>2012/12/12</edition><dates><year>2012</year></dates><isbn>1178-2234 (Electronic)&#xD;1178-2234 (Linking)</isbn><accession-num>23226022</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=23226022</url></related-urls></urls><electronic-resource-num>10.4137/BCBCR.S10293&#xD;bcbcr-6-2012-181 [pii]</electronic-resource-num><language>eng</language></record></Cite></EndNote>*	D<EndNote><Cite><Author>Acevedo</Author><Year>2012</Year><RecNum>2671</RecNum><DisplayText>[36, 37]</DisplayText><record><rec-number>2671</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2671</key></foreign-keys><ref-type name="Book Section">5</ref-type><contributors><authors><author>Acevedo, S. F.</author></authors><secondary-authors><author>Kostner, G.</author><author>Frank, S.</author></secondary-authors></contributors><titles><title>The confounding factor of Apolipoprotein E on response to chemotherapy and hormone regulation altering long-term cognition outcomes</title><secondary-title>Lipoproteins - Role in Health and Diseases</secondary-title></titles><section>10</section><dates><year>2012</year></dates><pub-location>Rijeka, Croatia</pub-location><publisher>InTech </publisher><urls></urls></record></Cite><Cite><Author>Acevedo</Author><Year>2012</Year><RecNum>2829</RecNum><record><rec-number>2829</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2829</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Acevedo, S. F.</author></authors></contributors><auth-address>Department of Physiology, Pharmacology, and Toxicology, Psychology Program, Ponce School of Medicine and Health Sciences, Ponce, Puerto Rico.</auth-address><titles><title>Why, After Chemotherapy, is it Necessary to Assess Memory Using Translational Testing?</title><secondary-title>Breast Cancer (Auckl)</secondary-title><alt-title>Breast Cancer: Basic and Clinical Research</alt-title></titles><periodical><full-title>Breast Cancer (Auckl)</full-title></periodical><alt-periodical><full-title>Breast Cancer: Basic and Clinical Research</full-title></alt-periodical><pages>181-90</pages><volume>6</volume><edition>2012/12/12</edition><dates><year>2012</year></dates><isbn>1178-2234 (Electronic)&#xD;1178-2234 (Linking)</isbn><accession-num>23226022</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=23226022</url></related-urls></urls><electronic-resource-num>10.4137/BCBCR.S10293&#xD;bcbcr-6-2012-181 [pii]</electronic-resource-num><language>eng</language></record></Cite></EndNote>�
D<EndNote><Cite><Author>Schilder</Author><Year>2010</Year><RecNum>2374</RecNum><DisplayText>[36, 39]</DisplayText><record><rec-number>2374</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2374</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Schilder, C. M.</author><author>Seynaeve, C.</author><author>Beex, L. V.</author><author>Boogerd, W.</author><author>Linn, S. C.</author><author>Gundy, C. M.</author><author>Huizenga, H. M.</author><author>Nortier, J. W.</author><author>van de Velde, C. J.</author><author>van Dam, F. S.</author><author>Schagen, S. B.</author></authors></contributors><auth-address>Department of Psychosocial Research and Epidemiology, Netherlands Cancer Institute Amsterdam, the Netherlands. s.schagen@nki.nl</auth-address><titles><title>Effects of tamoxifen and exemestane on cognitive functioning of postmenopausal patients with breast cancer: results from the neuropsychological side study of the tamoxifen and exemestane adjuvant multinational trial</title><secondary-title>J Clin Oncol</secondary-title></titles><periodical><full-title>J Clin Oncol</full-title></periodical><pages>1294-300</pages><volume>28</volume><number>8</number><edition>2010/02/10</edition><keywords><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Androstadienes/administration &amp; dosage/*adverse effects</keyword><keyword>Antineoplastic Agents, Hormonal/administration &amp; dosage/*adverse effects</keyword><keyword>Aromatase Inhibitors/administration &amp; dosage/*adverse effects</keyword><keyword>Breast Neoplasms/*drug therapy</keyword><keyword>Case-Control Studies</keyword><keyword>Cognition Disorders/*chemically induced</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Middle Aged</keyword><keyword>Netherlands</keyword><keyword>Postmenopause</keyword><keyword>Prospective Studies</keyword><keyword>Randomized Controlled Trials as Topic</keyword><keyword>Selective Estrogen Receptor Modulators/administration &amp; dosage/*adverse effects</keyword><keyword>Tamoxifen/administration &amp; dosage/*adverse effects</keyword></keywords><dates><year>2010</year><pub-dates><date>Mar 10</date></pub-dates></dates><isbn>1527-7755 (Electronic)&#xD;0732-183X (Linking)</isbn><accession-num>20142601</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=20142601</url></related-urls></urls><electronic-resource-num>JCO.2008.21.3553 [pii]&#xD;10.1200/JCO.2008.21.3553</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Acevedo</Author><Year>2012</Year><RecNum>2671</RecNum><record><rec-number>2671</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2671</key></foreign-keys><ref-type name="Book Section">5</ref-type><contributors><authors><author>Acevedo, S. F.</author></authors><secondary-authors><author>Kostner, G.</author><author>Frank, S.</author></secondary-authors></contributors><titles><title>The confounding factor of Apolipoprotein E on response to chemotherapy and hormone regulation altering long-term cognition outcomes</title><secondary-title>Lipoproteins - Role in Health and Diseases</secondary-title></titles><section>10</section><dates><year>2012</year></dates><pub-location>Rijeka, Croatia</pub-location><publisher>InTech </publisher><urls></urls></record></Cite></EndNote>�
D<EndNote><Cite><Author>Schilder</Author><Year>2010</Year><RecNum>2374</RecNum><DisplayText>[36, 39]</DisplayText><record><rec-number>2374</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2374</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Schilder, C. M.</author><author>Seynaeve, C.</author><author>Beex, L. V.</author><author>Boogerd, W.</author><author>Linn, S. C.</author><author>Gundy, C. M.</author><author>Huizenga, H. M.</author><author>Nortier, J. W.</author><author>van de Velde, C. J.</author><author>van Dam, F. S.</author><author>Schagen, S. B.</author></authors></contributors><auth-address>Department of Psychosocial Research and Epidemiology, Netherlands Cancer Institute Amsterdam, the Netherlands. s.schagen@nki.nl</auth-address><titles><title>Effects of tamoxifen and exemestane on cognitive functioning of postmenopausal patients with breast cancer: results from the neuropsychological side study of the tamoxifen and exemestane adjuvant multinational trial</title><secondary-title>J Clin Oncol</secondary-title></titles><periodical><full-title>J Clin Oncol</full-title></periodical><pages>1294-300</pages><volume>28</volume><number>8</number><edition>2010/02/10</edition><keywords><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Androstadienes/administration &amp; dosage/*adverse effects</keyword><keyword>Antineoplastic Agents, Hormonal/administration &amp; dosage/*adverse effects</keyword><keyword>Aromatase Inhibitors/administration &amp; dosage/*adverse effects</keyword><keyword>Breast Neoplasms/*drug therapy</keyword><keyword>Case-Control Studies</keyword><keyword>Cognition Disorders/*chemically induced</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Middle Aged</keyword><keyword>Netherlands</keyword><keyword>Postmenopause</keyword><keyword>Prospective Studies</keyword><keyword>Randomized Controlled Trials as Topic</keyword><keyword>Selective Estrogen Receptor Modulators/administration &amp; dosage/*adverse effects</keyword><keyword>Tamoxifen/administration &amp; dosage/*adverse effects</keyword></keywords><dates><year>2010</year><pub-dates><date>Mar 10</date></pub-dates></dates><isbn>1527-7755 (Electronic)&#xD;0732-183X (Linking)</isbn><accession-num>20142601</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=20142601</url></related-urls></urls><electronic-resource-num>JCO.2008.21.3553 [pii]&#xD;10.1200/JCO.2008.21.3553</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Acevedo</Author><Year>2012</Year><RecNum>2671</RecNum><record><rec-number>2671</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2671</key></foreign-keys><ref-type name="Book Section">5</ref-type><contributors><authors><author>Acevedo, S. F.</author></authors><secondary-authors><author>Kostner, G.</author><author>Frank, S.</author></secondary-authors></contributors><titles><title>The confounding factor of Apolipoprotein E on response to chemotherapy and hormone regulation altering long-term cognition outcomes</title><secondary-title>Lipoproteins - Role in Health and Diseases</secondary-title></titles><section>10</section><dates><year>2012</year></dates><pub-location>Rijeka, Croatia</pub-location><publisher>InTech </publisher><urls></urls></record></Cite></EndNote>D<EndNote><Cite><Author>Mahley</Author><Year>2006</Year><RecNum>2194</RecNum><DisplayText>[42, 43]</DisplayText><record><rec-number>2194</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2194</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Mahley, R. W.</author><author>Huang, Y.</author><author>Weisgraber, K. H.</author></authors></contributors><auth-address>Gladstone Institute of Neurological Disease and Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA. rmahley@gladstone.ucsf.edu</auth-address><titles><title>Putting cholesterol in its place: apoE and reverse cholesterol transport</title><secondary-title>J Clin Invest</secondary-title></titles><periodical><full-title>J Clin Invest</full-title></periodical><pages>1226-9</pages><volume>116</volume><number>5</number><edition>2006/05/04</edition><keywords><keyword>ATP-Binding Cassette Transporters/metabolism</keyword><keyword>Animals</keyword><keyword>Apolipoproteins E/metabolism/*physiology</keyword><keyword>Biological Transport</keyword><keyword>Carrier Proteins/metabolism</keyword><keyword>Cholesterol/*metabolism</keyword><keyword>Cholesterol Ester Transfer Proteins</keyword><keyword>Cholesterol, HDL/metabolism</keyword><keyword>Glycoproteins/metabolism</keyword><keyword>Humans</keyword><keyword>Macrophages/metabolism</keyword><keyword>Models, Biological</keyword></keywords><dates><year>2006</year><pub-dates><date>May</date></pub-dates></dates><isbn>0021-9738 (Print)&#xD;0021-9738 (Linking)</isbn><accession-num>16670767</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16670767</url></related-urls></urls><electronic-resource-num>10.1172/JCI28632</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Mahley</Author><Year>2000</Year><RecNum>2188</RecNum><record><rec-number>2188</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2188</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Mahley, R. W.</author><author>Rall, S. C., Jr.</author></authors></contributors><auth-address>Gladstone Institute of Cardiovascular Disease, University of California at San Francisco, San Francisco, California 94141-9100, USA. rmahley@gladstone.ucsf.edu</auth-address><titles><title>Apolipoprotein E: far more than a lipid transport protein</title><secondary-title>Annu Rev Genomics Hum Genet</secondary-title></titles><periodical><full-title>Annu Rev Genomics Hum Genet</full-title></periodical><pages>507-37</pages><volume>1</volume><edition>2001/11/10</edition><keywords><keyword>Alleles</keyword><keyword>Animals</keyword><keyword>Apolipoproteins E/chemistry/*genetics/*metabolism</keyword><keyword>Arteriosclerosis/etiology/genetics</keyword><keyword>Biological Transport, Active</keyword><keyword>Communicable Diseases/etiology/genetics</keyword><keyword>Female</keyword><keyword>Heart Diseases/etiology/genetics</keyword><keyword>Humans</keyword><keyword>Hyperlipoproteinemia Type III/genetics/metabolism</keyword><keyword>Immunity/genetics</keyword><keyword>*Lipid Metabolism</keyword><keyword>Lipoproteins/metabolism</keyword><keyword>Male</keyword><keyword>Models, Molecular</keyword><keyword>Neurobiology</keyword><keyword>Phenotype</keyword><keyword>Polymorphism, Genetic</keyword><keyword>Protein Isoforms/chemistry/genetics/metabolism</keyword><keyword>Reproduction/genetics</keyword><keyword>Risk Factors</keyword></keywords><dates><year>2000</year></dates><isbn>1527-8204 (Print)&#xD;1527-8204 (Linking)</isbn><accession-num>11701639</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=11701639</url></related-urls></urls><electronic-resource-num>1/1/507 [pii]&#xD;10.1146/annurev.genom.1.1.507</electronic-resource-num><language>eng</language></record></Cite></EndNote>D<EndNote><Cite><Author>Mahley</Author><Year>2006</Year><RecNum>2194</RecNum><DisplayText>[42, 43]</DisplayText><record><rec-number>2194</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2194</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Mahley, R. 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H.</author></authors></contributors><auth-address>Gladstone Institute of Neurological Disease and Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA. rmahley@gladstone.ucsf.edu</auth-address><titles><title>Putting cholesterol in its place: apoE and reverse cholesterol transport</title><secondary-title>J Clin Invest</secondary-title></titles><periodical><full-title>J Clin Invest</full-title></periodical><pages>1226-9</pages><volume>116</volume><number>5</number><edition>2006/05/04</edition><keywords><keyword>ATP-Binding Cassette Transporters/metabolism</keyword><keyword>Animals</keyword><keyword>Apolipoproteins E/metabolism/*physiology</keyword><keyword>Biological Transport</keyword><keyword>Carrier Proteins/metabolism</keyword><keyword>Cholesterol/*metabolism</keyword><keyword>Cholesterol Ester Transfer Proteins</keyword><keyword>Cholesterol, HDL/metabolism</keyword><keyword>Glycoproteins/metabolism</keyword><keyword>Humans</keyword><keyword>Macrophages/metabolism</keyword><keyword>Models, Biological</keyword></keywords><dates><year>2006</year><pub-dates><date>May</date></pub-dates></dates><isbn>0021-9738 (Print)&#xD;0021-9738 (Linking)</isbn><accession-num>16670767</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16670767</url></related-urls></urls><electronic-resource-num>10.1172/JCI28632</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Mahley</Author><Year>2000</Year><RecNum>2188</RecNum><record><rec-number>2188</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2188</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Mahley, R. W.</author><author>Rall, S. C., Jr.</author></authors></contributors><auth-address>Gladstone Institute of Cardiovascular Disease, University of California at San Francisco, San Francisco, California 94141-9100, USA. rmahley@gladstone.ucsf.edu</auth-address><titles><title>Apolipoprotein E: far more than a lipid transport protein</title><secondary-title>Annu Rev Genomics Hum Genet</secondary-title></titles><periodical><full-title>Annu Rev Genomics Hum Genet</full-title></periodical><pages>507-37</pages><volume>1</volume><edition>2001/11/10</edition><keywords><keyword>Alleles</keyword><keyword>Animals</keyword><keyword>Apolipoproteins E/chemistry/*genetics/*metabolism</keyword><keyword>Arteriosclerosis/etiology/genetics</keyword><keyword>Biological Transport, Active</keyword><keyword>Communicable Diseases/etiology/genetics</keyword><keyword>Female</keyword><keyword>Heart Diseases/etiology/genetics</keyword><keyword>Humans</keyword><keyword>Hyperlipoproteinemia Type III/genetics/metabolism</keyword><keyword>Immunity/genetics</keyword><keyword>*Lipid Metabolism</keyword><keyword>Lipoproteins/metabolism</keyword><keyword>Male</keyword><keyword>Models, Molecular</keyword><keyword>Neurobiology</keyword><keyword>Phenotype</keyword><keyword>Polymorphism, Genetic</keyword><keyword>Protein Isoforms/chemistry/genetics/metabolism</keyword><keyword>Reproduction/genetics</keyword><keyword>Risk Factors</keyword></keywords><dates><year>2000</year></dates><isbn>1527-8204 (Print)&#xD;1527-8204 (Linking)</isbn><accession-num>11701639</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=11701639</url></related-urls></urls><electronic-resource-num>1/1/507 [pii]&#xD;10.1146/annurev.genom.1.1.507</electronic-resource-num><language>eng</language></record></Cite></EndNote>4D<EndNote><Cite><Author>Mahley</Author><Year>2006</Year><RecNum>2194</RecNum><DisplayText>[42-44]</DisplayText><record><rec-number>2194</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2194</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Mahley, R. 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W.</author><author>Huang, Y.</author><author>Weisgraber, K. H.</author></authors></contributors><auth-address>Gladstone Institute of Neurological Disease and Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA. rmahley@gladstone.ucsf.edu</auth-address><titles><title>Putting cholesterol in its place: apoE and reverse cholesterol transport</title><secondary-title>J Clin Invest</secondary-title></titles><periodical><full-title>J Clin Invest</full-title></periodical><pages>1226-9</pages><volume>116</volume><number>5</number><edition>2006/05/04</edition><keywords><keyword>ATP-Binding Cassette Transporters/metabolism</keyword><keyword>Animals</keyword><keyword>Apolipoproteins E/metabolism/*physiology</keyword><keyword>Biological Transport</keyword><keyword>Carrier Proteins/metabolism</keyword><keyword>Cholesterol/*metabolism</keyword><keyword>Cholesterol Ester Transfer Proteins</keyword><keyword>Cholesterol, HDL/metabolism</keyword><keyword>Glycoproteins/metabolism</keyword><keyword>Humans</keyword><keyword>Macrophages/metabolism</keyword><keyword>Models, Biological</keyword></keywords><dates><year>2006</year><pub-dates><date>May</date></pub-dates></dates><isbn>0021-9738 (Print)&#xD;0021-9738 (Linking)</isbn><accession-num>16670767</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16670767</url></related-urls></urls><electronic-resource-num>10.1172/JCI28632</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Mahley</Author><Year>2000</Year><RecNum>2188</RecNum><record><rec-number>2188</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2188</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Mahley, R. W.</author><author>Rall, S. C., Jr.</author></authors></contributors><auth-address>Gladstone Institute of Cardiovascular Disease, University of California at San Francisco, San Francisco, California 94141-9100, USA. rmahley@gladstone.ucsf.edu</auth-address><titles><title>Apolipoprotein E: far more than a lipid transport protein</title><secondary-title>Annu Rev Genomics Hum Genet</secondary-title></titles><periodical><full-title>Annu Rev Genomics Hum Genet</full-title></periodical><pages>507-37</pages><volume>1</volume><edition>2001/11/10</edition><keywords><keyword>Alleles</keyword><keyword>Animals</keyword><keyword>Apolipoproteins E/chemistry/*genetics/*metabolism</keyword><keyword>Arteriosclerosis/etiology/genetics</keyword><keyword>Biological Transport, Active</keyword><keyword>Communicable Diseases/etiology/genetics</keyword><keyword>Female</keyword><keyword>Heart Diseases/etiology/genetics</keyword><keyword>Humans</keyword><keyword>Hyperlipoproteinemia Type III/genetics/metabolism</keyword><keyword>Immunity/genetics</keyword><keyword>*Lipid Metabolism</keyword><keyword>Lipoproteins/metabolism</keyword><keyword>Male</keyword><keyword>Models, Molecular</keyword><keyword>Neurobiology</keyword><keyword>Phenotype</keyword><keyword>Polymorphism, Genetic</keyword><keyword>Protein Isoforms/chemistry/genetics/metabolism</keyword><keyword>Reproduction/genetics</keyword><keyword>Risk Factors</keyword></keywords><dates><year>2000</year></dates><isbn>1527-8204 (Print)&#xD;1527-8204 (Linking)</isbn><accession-num>11701639</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=11701639</url></related-urls></urls><electronic-resource-num>1/1/507 [pii]&#xD;10.1146/annurev.genom.1.1.507</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Han</Author><Year>2004</Year><RecNum>623</RecNum><record><rec-number>623</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">623</key><key app="ENWeb" db-id="TWVFEgrtqgcAAHXhYvY">340</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Han, X.</author></authors></contributors><auth-address>Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, Box 8020, 660 South Euclid Avenue, 63110, St. Louis, Missouri, USA. xianlin@wustl.edu</auth-address><titles><title>The role of apolipoprotein E in lipid metabolism in the central nervous system</title><secondary-title>Cell Mol Life Sci</secondary-title></titles><periodical><full-title>Cell Mol Life Sci</full-title></periodical><pages>1896-906</pages><volume>61</volume><number>15</number><keywords><keyword>Animals</keyword><keyword>Apolipoproteins E/*metabolism</keyword><keyword>Central Nervous System/*metabolism</keyword><keyword>Cholesterol/*metabolism</keyword><keyword>Humans</keyword><keyword>Phospholipids/*metabolism</keyword><keyword>Sulfoglycosphingolipids/*metabolism</keyword></keywords><dates><year>2004</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>1420-682X (Print)</isbn><accession-num>15289932</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=15289932</url></related-urls></urls><language>eng</language></record></Cite></EndNote>PD<EndNote><Cite><Author>Mahley</Author><Year>2009</Year><RecNum>1803</RecNum><DisplayText>[41, 46]</DisplayText><record><rec-number>1803</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">1803</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Mahley, R. W.</author><author>Weisgraber, K. H.</author><author>Huang, Y.</author></authors></contributors><auth-address>Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA. rmahley@gladstone.ucsf.edu</auth-address><titles><title>Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer&apos;s disease to AIDS</title><secondary-title>J Lipid Res</secondary-title></titles><periodical><full-title>J Lipid Res</full-title></periodical><pages>S183-8</pages><volume>50 Suppl</volume><edition>2008/12/25</edition><keywords><keyword>Acquired Immunodeficiency Syndrome/genetics/ metabolism</keyword><keyword>Alzheimer Disease/genetics/ metabolism</keyword><keyword>Animals</keyword><keyword>Apolipoproteins E/ chemistry/genetics/immunology/ metabolism</keyword><keyword>Atherosclerosis/genetics/ metabolism</keyword><keyword>Humans</keyword><keyword>Protein Binding</keyword></keywords><dates><year>2009</year><pub-dates><date>Apr</date></pub-dates></dates><isbn>0022-2275 (Print)&#xD;0022-2275 (Linking)</isbn><accession-num>19106071</accession-num><urls></urls><electronic-resource-num>R800069-JLR200 [pii]&#xD;10.1194/jlr.R800069-JLR200 [doi]</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Struble</Author><Year>2008</Year><RecNum>2391</RecNum><record><rec-number>2391</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2391</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Struble, R. G.</author><author>Cady, C.</author><author>Nathan, B. P.</author><author>McAsey, M.</author></authors></contributors><auth-address>Center for Alzheimer&apos;s Disease and Related Disorders, Department of Neurology, Southern Illinois University School of Medicine, P.O. Box 19643, Springfield, IL 62794-9643, USA. rstruble@siumed.edu</auth-address><titles><title>Apolipoprotein E may be a critical factor in hormone therapy neuroprotection</title><secondary-title>Front Biosci</secondary-title></titles><periodical><full-title>Front Biosci</full-title></periodical><pages>5387-405</pages><volume>13</volume><edition>2008/05/30</edition><keywords><keyword>Animals</keyword><keyword>Apolipoproteins E/deficiency/genetics/*physiology</keyword><keyword>Chronic Disease</keyword><keyword>Dementia/drug therapy/physiopathology/prevention &amp; control</keyword><keyword>Estrogen Replacement Therapy</keyword><keyword>Female</keyword><keyword>Hormones/*therapeutic use</keyword><keyword>Humans</keyword><keyword>Menopause/physiology</keyword><keyword>Menstrual Cycle/physiology</keyword><keyword>Mice</keyword><keyword>Mice, Knockout</keyword><keyword>Models, Animal</keyword><keyword>Nervous System Diseases/physiopathology</keyword><keyword>*Neuroprotective Agents</keyword><keyword>Stroke/physiopathology</keyword></keywords><dates><year>2008</year></dates><isbn>1093-4715 (Electronic)&#xD;1093-4715 (Linking)</isbn><accession-num>18508594</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=18508594</url></related-urls></urls><electronic-resource-num>3088 [pii]</electronic-resource-num><language>eng</language></record></Cite></EndNote>PD<EndNote><Cite><Author>Mahley</Author><Year>2009</Year><RecNum>1803</RecNum><DisplayText>[41, 46]</DisplayText><record><rec-number>1803</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">1803</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Mahley, R. W.</author><author>Weisgraber, K. H.</author><author>Huang, Y.</author></authors></contributors><auth-address>Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA. rmahley@gladstone.ucsf.edu</auth-address><titles><title>Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer&apos;s disease to AIDS</title><secondary-title>J Lipid Res</secondary-title></titles><periodical><full-title>J Lipid Res</full-title></periodical><pages>S183-8</pages><volume>50 Suppl</volume><edition>2008/12/25</edition><keywords><keyword>Acquired Immunodeficiency Syndrome/genetics/ metabolism</keyword><keyword>Alzheimer Disease/genetics/ metabolism</keyword><keyword>Animals</keyword><keyword>Apolipoproteins E/ chemistry/genetics/immunology/ metabolism</keyword><keyword>Atherosclerosis/genetics/ metabolism</keyword><keyword>Humans</keyword><keyword>Protein Binding</keyword></keywords><dates><year>2009</year><pub-dates><date>Apr</date></pub-dates></dates><isbn>0022-2275 (Print)&#xD;0022-2275 (Linking)</isbn><accession-num>19106071</accession-num><urls></urls><electronic-resource-num>R800069-JLR200 [pii]&#xD;10.1194/jlr.R800069-JLR200 [doi]</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Struble</Author><Year>2008</Year><RecNum>2391</RecNum><record><rec-number>2391</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2391</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Struble, R. G.</author><author>Cady, C.</author><author>Nathan, B. P.</author><author>McAsey, M.</author></authors></contributors><auth-address>Center for Alzheimer&apos;s Disease and Related Disorders, Department of Neurology, Southern Illinois University School of Medicine, P.O. Box 19643, Springfield, IL 62794-9643, USA. rstruble@siumed.edu</auth-address><titles><title>Apolipoprotein E may be a critical factor in hormone therapy neuroprotection</title><secondary-title>Front Biosci</secondary-title></titles><periodical><full-title>Front Biosci</full-title></periodical><pages>5387-405</pages><volume>13</volume><edition>2008/05/30</edition><keywords><keyword>Animals</keyword><keyword>Apolipoproteins E/deficiency/genetics/*physiology</keyword><keyword>Chronic Disease</keyword><keyword>Dementia/drug therapy/physiopathology/prevention &amp; control</keyword><keyword>Estrogen Replacement Therapy</keyword><keyword>Female</keyword><keyword>Hormones/*therapeutic use</keyword><keyword>Humans</keyword><keyword>Menopause/physiology</keyword><keyword>Menstrual Cycle/physiology</keyword><keyword>Mice</keyword><keyword>Mice, Knockout</keyword><keyword>Models, Animal</keyword><keyword>Nervous System Diseases/physiopathology</keyword><keyword>*Neuroprotective Agents</keyword><keyword>Stroke/physiopathology</keyword></keywords><dates><year>2008</year></dates><isbn>1093-4715 (Electronic)&#xD;1093-4715 (Linking)</isbn><accession-num>18508594</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=18508594</url></related-urls></urls><electronic-resource-num>3088 [pii]</electronic-resource-num><language>eng</language></record></Cite></EndNote>�D<EndNote><Cite><Author>Mahley</Author><Year>2009</Year><RecNum>1803</RecNum><DisplayText>[41, 47, 48]</DisplayText><record><rec-number>1803</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">1803</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Mahley, R. W.</author><author>Weisgraber, K. H.</author><author>Huang, Y.</author></authors></contributors><auth-address>Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA. rmahley@gladstone.ucsf.edu</auth-address><titles><title>Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer&apos;s disease to AIDS</title><secondary-title>J Lipid Res</secondary-title></titles><periodical><full-title>J Lipid Res</full-title></periodical><pages>S183-8</pages><volume>50 Suppl</volume><edition>2008/12/25</edition><keywords><keyword>Acquired Immunodeficiency Syndrome/genetics/ metabolism</keyword><keyword>Alzheimer Disease/genetics/ metabolism</keyword><keyword>Animals</keyword><keyword>Apolipoproteins E/ chemistry/genetics/immunology/ metabolism</keyword><keyword>Atherosclerosis/genetics/ metabolism</keyword><keyword>Humans</keyword><keyword>Protein Binding</keyword></keywords><dates><year>2009</year><pub-dates><date>Apr</date></pub-dates></dates><isbn>0022-2275 (Print)&#xD;0022-2275 (Linking)</isbn><accession-num>19106071</accession-num><urls></urls><electronic-resource-num>R800069-JLR200 [pii]&#xD;10.1194/jlr.R800069-JLR200 [doi]</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Villasana</Author><Year>2006</Year><RecNum>1529</RecNum><record><rec-number>1529</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">1529</key><key app="ENWeb" db-id="TWVFEgrtqgcAAHXhYvY">294</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Villasana, L.</author><author>Acevedo, S.</author><author>Poage, C.</author><author>Raber, J.</author></authors></contributors><auth-address>Department of Behavioral Neuroscience, ONPRC, Oregon Health &amp; Science University, Portland, Oregon 97239, USA.</auth-address><titles><title>Sex- and APOE isoform-dependent effects of radiation on cognitive function</title><secondary-title>Radiat Res</secondary-title><alt-title>Radiation research</alt-title></titles><periodical><full-title>Radiat Res</full-title></periodical><pages>883-91</pages><volume>166</volume><number>6</number><keywords><keyword>Animals</keyword><keyword>Apolipoproteins E/*metabolism</keyword><keyword>Behavior, Animal/*physiology/*radiation effects</keyword><keyword>Cognition/*physiology/*radiation effects</keyword><keyword>Female</keyword><keyword>Male</keyword><keyword>Maze Learning/*physiology/*radiation effects</keyword><keyword>Mice</keyword><keyword>Mice, Inbred C57BL</keyword><keyword>Protein Isoforms/metabolism</keyword><keyword>Sex Factors</keyword></keywords><dates><year>2006</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>0033-7587 (Print)</isbn><accession-num>17149978</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=17149978</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Raber</Author><Year>2008</Year><RecNum>1166</RecNum><record><rec-number>1166</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">1166</key><key app="ENWeb" db-id="TWVFEgrtqgcAAHXhYvY">1207</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Raber, J.</author></authors></contributors><auth-address>Department of Behavioral Neuroscience, Division of Neuroscience, ONPRC, Oregon Health &amp; Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. raberj@ohsu.edu</auth-address><titles><title>AR, apoE, and cognitive function</title><secondary-title>Horm Behav</secondary-title></titles><periodical><full-title>Horm Behav</full-title><abbr-1>Hormones and behavior</abbr-1></periodical><pages>706-15</pages><volume>53</volume><number>5</number><edition>2008/04/09</edition><keywords><keyword>Aged</keyword><keyword>Aging/physiology</keyword><keyword>Alzheimer Disease/genetics/physiopathology</keyword><keyword>Androgens/pharmacology/*physiology/therapeutic use</keyword><keyword>Apolipoproteins E/*physiology</keyword><keyword>Cognition/drug effects/*physiology</keyword><keyword>Cognition Disorders/genetics/physiopathology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Receptors, Androgen/*physiology</keyword><keyword>Risk Factors</keyword><keyword>Sex Characteristics</keyword><keyword>Testosterone/metabolism</keyword></keywords><dates><year>2008</year><pub-dates><date>May</date></pub-dates></dates><isbn>0018-506X (Print)</isbn><accession-num>18395206</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=18395206</url></related-urls></urls><electronic-resource-num>S0018-506X(08)00055-X [pii]&#xD;10.1016/j.yhbeh.2008.02.012</electronic-resource-num><language>eng</language></record></Cite></EndNote>�D<EndNote><Cite><Author>Mahley</Author><Year>2009</Year><RecNum>1803</RecNum><DisplayText>[41, 47, 48]</DisplayText><record><rec-number>1803</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">1803</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Mahley, R. W.</author><author>Weisgraber, K. H.</author><author>Huang, Y.</author></authors></contributors><auth-address>Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA. rmahley@gladstone.ucsf.edu</auth-address><titles><title>Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer&apos;s disease to AIDS</title><secondary-title>J Lipid Res</secondary-title></titles><periodical><full-title>J Lipid Res</full-title></periodical><pages>S183-8</pages><volume>50 Suppl</volume><edition>2008/12/25</edition><keywords><keyword>Acquired Immunodeficiency Syndrome/genetics/ metabolism</keyword><keyword>Alzheimer Disease/genetics/ metabolism</keyword><keyword>Animals</keyword><keyword>Apolipoproteins E/ chemistry/genetics/immunology/ metabolism</keyword><keyword>Atherosclerosis/genetics/ metabolism</keyword><keyword>Humans</keyword><keyword>Protein Binding</keyword></keywords><dates><year>2009</year><pub-dates><date>Apr</date></pub-dates></dates><isbn>0022-2275 (Print)&#xD;0022-2275 (Linking)</isbn><accession-num>19106071</accession-num><urls></urls><electronic-resource-num>R800069-JLR200 [pii]&#xD;10.1194/jlr.R800069-JLR200 [doi]</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Villasana</Author><Year>2006</Year><RecNum>1529</RecNum><record><rec-number>1529</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">1529</key><key app="ENWeb" db-id="TWVFEgrtqgcAAHXhYvY">294</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Villasana, L.</author><author>Acevedo, S.</author><author>Poage, C.</author><author>Raber, J.</author></authors></contributors><auth-address>Department of Behavioral Neuroscience, ONPRC, Oregon Health &amp; Science University, Portland, Oregon 97239, USA.</auth-address><titles><title>Sex- and APOE isoform-dependent effects of radiation on cognitive function</title><secondary-title>Radiat Res</secondary-title><alt-title>Radiation research</alt-title></titles><periodical><full-title>Radiat Res</full-title></periodical><pages>883-91</pages><volume>166</volume><number>6</number><keywords><keyword>Animals</keyword><keyword>Apolipoproteins E/*metabolism</keyword><keyword>Behavior, Animal/*physiology/*radiation effects</keyword><keyword>Cognition/*physiology/*radiation effects</keyword><keyword>Female</keyword><keyword>Male</keyword><keyword>Maze Learning/*physiology/*radiation effects</keyword><keyword>Mice</keyword><keyword>Mice, Inbred C57BL</keyword><keyword>Protein Isoforms/metabolism</keyword><keyword>Sex Factors</keyword></keywords><dates><year>2006</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>0033-7587 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M.J.</author></authors></contributors><auth-address>Department of Psychology, University of New Mexico, Albuquerque, NM, USA.</auth-address><titles><title>Apolipoprotein E and prospective memory in normally aging adults</title><secondary-title>Neuropsychology</secondary-title><alt-title>Neuropsychology</alt-title></titles><periodical><full-title>Neuropsychology</full-title><abbr-1>Neuropsychology</abbr-1></periodical><alt-periodical><full-title>Neuropsychology</full-title><abbr-1>Neuropsychology</abbr-1></alt-periodical><pages>28-34</pages><volume>19</volume><number>1</number><keywords><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Aging/*physiology</keyword><keyword>Alleles</keyword><keyword>Analysis of Variance</keyword><keyword>Apolipoproteins E/genetics/*physiology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Memory/*physiology</keyword><keyword>Middle Aged</keyword><keyword>Neuropsychological Tests/statistics &amp; 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of APOE genotype to neuropsychological performance in long-term cancer survivors treated with standard dose chemotherapy.</title><secondary-title>Psychooncology</secondary-title><alt-title>Psycho-oncology</alt-title></titles><periodical><full-title>Psychooncology</full-title></periodical><alt-periodical><full-title>Psychooncology</full-title><abbr-1>Psycho-oncology</abbr-1></alt-periodical><pages>612-9</pages><volume>12</volume><number>6</number><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Antineoplastic Combined Chemotherapy Protocols/*adverse</keyword><keyword>effects/therapeutic use</keyword><keyword>Apolipoproteins E/*genetics</keyword><keyword>Breast Neoplasms/drug therapy/*genetics/*psychology</keyword><keyword>Cognition Disorders/*etiology/genetics</keyword><keyword>Female</keyword><keyword>*Genetic Markers</keyword><keyword>Genotype</keyword><keyword>Humans</keyword><keyword>Lymphoma/drug therapy/*genetics/*psychology</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Neuropsychological Tests</keyword><keyword>Risk Factors</keyword><keyword>Survivors/*psychology</keyword></keywords><dates><year>2003</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>1057-9249 (Print)</isbn><accession-num>12923801</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=12923801</url></related-urls></urls><language>eng</language></record></Cite></EndNote>	D<EndNote><Cite><Author>Ahles</Author><Year>2003</Year><RecNum>36</RecNum><DisplayText>[56]</DisplayText><record><rec-number>36</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">36</key><key app="ENWeb" db-id="TWVFEgrtqgcAAHXhYvY">55</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ahles, T.A.</author><author>Saykin, A.J.</author><author>Noll, W.W.</author><author>Furstenberg, C.T.</author><author>Guerin, S.</author><author>Cole, B.</author><author>Mott, L.A.</author></authors></contributors><auth-address>Department of Psychiatry and Center for Psycho-Oncology Research, USA. tim.a.ahles@dartmouth.edu</auth-address><titles><title>The relationship of APOE genotype to neuropsychological performance in long-term cancer survivors treated with standard dose chemotherapy.</title><secondary-title>Psychooncology</secondary-title><alt-title>Psycho-oncology</alt-title></titles><periodical><full-title>Psychooncology</full-title></periodical><alt-periodical><full-title>Psychooncology</full-title><abbr-1>Psycho-oncology</abbr-1></alt-periodical><pages>612-9</pages><volume>12</volume><number>6</number><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Antineoplastic Combined Chemotherapy Protocols/*adverse</keyword><keyword>effects/therapeutic use</keyword><keyword>Apolipoproteins E/*genetics</keyword><keyword>Breast Neoplasms/drug therapy/*genetics/*psychology</keyword><keyword>Cognition Disorders/*etiology/genetics</keyword><keyword>Female</keyword><keyword>*Genetic Markers</keyword><keyword>Genotype</keyword><keyword>Humans</keyword><keyword>Lymphoma/drug therapy/*genetics/*psychology</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Neuropsychological Tests</keyword><keyword>Risk Factors</keyword><keyword>Survivors/*psychology</keyword></keywords><dates><year>2003</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>1057-9249 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spatial navigation in the elderly</title><secondary-title>Neuroscience</secondary-title><alt-title>Neuroscience</alt-title></titles><periodical><full-title>Neuroscience</full-title></periodical><alt-periodical><full-title>Neuroscience</full-title></alt-periodical><pages>6-17</pages><volume>147</volume><number>1</number><keywords><keyword>Aged, 80 and over</keyword><keyword>Analysis of Variance</keyword><keyword>Apolipoprotein E2/metabolism</keyword><keyword>Apolipoprotein E4/*genetics</keyword><keyword>Cognition/*physiology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Hydrocortisone/metabolism</keyword><keyword>Male</keyword><keyword>Matched-Pair Analysis</keyword><keyword>Pattern Recognition, Visual/*physiology</keyword><keyword>Photic Stimulation</keyword><keyword>Reaction Time/physiology</keyword><keyword>Recognition (Psychology)/*physiology</keyword><keyword>Reference Values</keyword><keyword>Saliva/metabolism</keyword><keyword>Sex Factors</keyword><keyword>Single-Blind Method</keyword><keyword>Space Perception/physiology</keyword><keyword>Spatial Behavior/*physiology</keyword><keyword>Statistics, Nonparametric</keyword><keyword>Testosterone/metabolism</keyword></keywords><dates><year>2007</year><pub-dates><date>Jun 15</date></pub-dates></dates><isbn>0306-4522 (Print)</isbn><accession-num>17509769</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=17509769</url></related-urls></urls><language>eng</language></record></Cite></EndNote>B	D<EndNote><Cite><Author>Berteau-Pavy</Author><Year>2007</Year><RecNum>162</RecNum><DisplayText>[49]</DisplayText><record><rec-number>162</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">162</key><key app="ENWeb" db-id="TWVFEgrtqgcAAHXhYvY">178</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Berteau-Pavy, F.</author><author>Park, B.</author><author>Raber, J.</author></authors></contributors><auth-address>Department of Behavioral Neuroscience, L470, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA.</auth-address><titles><title>Effects of sex and APOE epsilon4 on object recognition and spatial navigation in the elderly</title><secondary-title>Neuroscience</secondary-title><alt-title>Neuroscience</alt-title></titles><periodical><full-title>Neuroscience</full-title></periodical><alt-periodical><full-title>Neuroscience</full-title></alt-periodical><pages>6-17</pages><volume>147</volume><number>1</number><keywords><keyword>Aged, 80 and over</keyword><keyword>Analysis of Variance</keyword><keyword>Apolipoprotein E2/metabolism</keyword><keyword>Apolipoprotein E4/*genetics</keyword><keyword>Cognition/*physiology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Hydrocortisone/metabolism</keyword><keyword>Male</keyword><keyword>Matched-Pair Analysis</keyword><keyword>Pattern Recognition, Visual/*physiology</keyword><keyword>Photic Stimulation</keyword><keyword>Reaction Time/physiology</keyword><keyword>Recognition (Psychology)/*physiology</keyword><keyword>Reference Values</keyword><keyword>Saliva/metabolism</keyword><keyword>Sex Factors</keyword><keyword>Single-Blind Method</keyword><keyword>Space Perception/physiology</keyword><keyword>Spatial Behavior/*physiology</keyword><keyword>Statistics, Nonparametric</keyword><keyword>Testosterone/metabolism</keyword></keywords><dates><year>2007</year><pub-dates><date>Jun 15</date></pub-dates></dates><isbn>0306-4522 (Print)</isbn><accession-num>17509769</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=17509769</url></related-urls></urls><language>eng</language></record></Cite></EndNote>�D<EndNote><Cite><Author>Chang</Author><Year>2009</Year><RecNum>282</RecNum><DisplayText>[57, 58]</DisplayText><record><rec-number>282</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">282</key><key app="ENWeb" db-id="TWVFEgrtqgcAAHXhYvY">1316</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Chang, N. 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R.</author></authors></contributors><auth-address>Department of Biochemistry, College of Medicine, China Medical University, Taiwan, ROC. nwchang@mail.cmu.edu.tw</auth-address><titles><title>Apolipoprotein E4 allele influences the response of plasma triglyceride levels to tamoxifen in breast cancer patients</title><secondary-title>Clin Chim Acta</secondary-title><alt-title>Clinica Chimica Acta</alt-title></titles><periodical><full-title>Clin Chim Acta</full-title></periodical><pages>144-7</pages><volume>401</volume><number>1-2</number><edition>2008/12/24</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Alleles</keyword><keyword>Apolipoprotein E4/*genetics</keyword><keyword>Breast Neoplasms/*blood/drug therapy/*genetics</keyword><keyword>Cholesterol, HDL/blood</keyword><keyword>Cholesterol, LDL/blood</keyword><keyword>Female</keyword><keyword>Genotype</keyword><keyword>Humans</keyword><keyword>Middle Aged</keyword><keyword>Polymorphism, Genetic</keyword><keyword>Tamoxifen/administration &amp; dosage/*therapeutic use</keyword><keyword>Triglycerides/*blood</keyword></keywords><dates><year>2009</year><pub-dates><date>Mar</date></pub-dates></dates><isbn>1873-3492 (Electronic)</isbn><accession-num>19103187</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=19103187</url></related-urls></urls><electronic-resource-num>S0009-8981(08)00597-4 [pii]&#xD;10.1016/j.cca.2008.12.005</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Liberopoulos</Author><Year>2002</Year><RecNum>846</RecNum><record><rec-number>846</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">846</key><key app="ENWeb" db-id="TWVFEgrtqgcAAHXhYvY">735</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Liberopoulos, E.</author><author>Karabina, S.A.</author><author>Tselepis, A.</author><author>Bairaktari, E.</author><author>Nicolaides, C.</author><author>Pavlidis, N.</author><author>Elisaf, M.</author></authors></contributors><auth-address>Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece.</auth-address><titles><title>Are the effects of tamoxifen on the serum lipid profile modified by apolipoprotein E phenotypes?</title><secondary-title>Oncology</secondary-title><alt-title>Oncology</alt-title></titles><periodical><full-title>Oncology</full-title><abbr-1>Oncology</abbr-1></periodical><alt-periodical><full-title>Oncology</full-title><abbr-1>Oncology</abbr-1></alt-periodical><pages>115-20</pages><volume>62</volume><number>2</number><keywords><keyword>Aged</keyword><keyword>Antineoplastic Agents, Hormonal/*pharmacology/therapeutic use</keyword><keyword>Apolipoproteins E/*genetics</keyword><keyword>Breast Neoplasms/*blood/drug therapy</keyword><keyword>Cholesterol, HDL/blood</keyword><keyword>Cholesterol, LDL/blood</keyword><keyword>Estrogen Receptor Modulators/*pharmacology/therapeutic use</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Lipids/*blood</keyword><keyword>Middle Aged</keyword><keyword>Phenotype</keyword><keyword>Postmenopause/*blood</keyword><keyword>Tamoxifen/*pharmacology/therapeutic use</keyword><keyword>Triglycerides/blood</keyword></keywords><dates><year>2002</year></dates><isbn>0030-2414 (Print)</isbn><accession-num>11914596</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=11914596</url></related-urls></urls><language>eng</language></record></Cite></EndNote>�D<EndNote><Cite><Author>Chang</Author><Year>2009</Year><RecNum>282</RecNum><DisplayText>[57, 58]</DisplayText><record><rec-number>282</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">282</key><key app="ENWeb" db-id="TWVFEgrtqgcAAHXhYvY">1316</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Chang, N. W.</author><author>Chen, F. N.</author><author>Wu, C. T.</author><author>Lin, C. F.</author><author>Chen, D. R.</author></authors></contributors><auth-address>Department of Biochemistry, College of Medicine, China Medical University, Taiwan, ROC. nwchang@mail.cmu.edu.tw</auth-address><titles><title>Apolipoprotein E4 allele influences the response of plasma triglyceride levels to tamoxifen in breast cancer patients</title><secondary-title>Clin Chim Acta</secondary-title><alt-title>Clinica Chimica Acta</alt-title></titles><periodical><full-title>Clin Chim Acta</full-title></periodical><pages>144-7</pages><volume>401</volume><number>1-2</number><edition>2008/12/24</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Alleles</keyword><keyword>Apolipoprotein E4/*genetics</keyword><keyword>Breast Neoplasms/*blood/drug therapy/*genetics</keyword><keyword>Cholesterol, HDL/blood</keyword><keyword>Cholesterol, LDL/blood</keyword><keyword>Female</keyword><keyword>Genotype</keyword><keyword>Humans</keyword><keyword>Middle Aged</keyword><keyword>Polymorphism, Genetic</keyword><keyword>Tamoxifen/administration &amp; dosage/*therapeutic use</keyword><keyword>Triglycerides/*blood</keyword></keywords><dates><year>2009</year><pub-dates><date>Mar</date></pub-dates></dates><isbn>1873-3492 (Electronic)</isbn><accession-num>19103187</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=19103187</url></related-urls></urls><electronic-resource-num>S0009-8981(08)00597-4 [pii]&#xD;10.1016/j.cca.2008.12.005</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Liberopoulos</Author><Year>2002</Year><RecNum>846</RecNum><record><rec-number>846</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">846</key><key app="ENWeb" db-id="TWVFEgrtqgcAAHXhYvY">735</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Liberopoulos, E.</author><author>Karabina, S.A.</author><author>Tselepis, A.</author><author>Bairaktari, E.</author><author>Nicolaides, C.</author><author>Pavlidis, N.</author><author>Elisaf, M.</author></authors></contributors><auth-address>Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece.</auth-address><titles><title>Are the effects of tamoxifen on the serum lipid profile modified by apolipoprotein E phenotypes?</title><secondary-title>Oncology</secondary-title><alt-title>Oncology</alt-title></titles><periodical><full-title>Oncology</full-title><abbr-1>Oncology</abbr-1></periodical><alt-periodical><full-title>Oncology</full-title><abbr-1>Oncology</abbr-1></alt-periodical><pages>115-20</pages><volume>62</volume><number>2</number><keywords><keyword>Aged</keyword><keyword>Antineoplastic Agents, Hormonal/*pharmacology/therapeutic use</keyword><keyword>Apolipoproteins E/*genetics</keyword><keyword>Breast Neoplasms/*blood/drug therapy</keyword><keyword>Cholesterol, HDL/blood</keyword><keyword>Cholesterol, LDL/blood</keyword><keyword>Estrogen Receptor Modulators/*pharmacology/therapeutic use</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Lipids/*blood</keyword><keyword>Middle Aged</keyword><keyword>Phenotype</keyword><keyword>Postmenopause/*blood</keyword><keyword>Tamoxifen/*pharmacology/therapeutic use</keyword><keyword>Triglycerides/blood</keyword></keywords><dates><year>2002</year></dates><isbn>0030-2414 (Print)</isbn><accession-num>11914596</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=11914596</url></related-urls></urls><language>eng</language></record></Cite></EndNote>�D<EndNote><Cite><Author>Liberopoulos</Author><Year>2002</Year><RecNum>846</RecNum><DisplayText>[58]</DisplayText><record><rec-number>846</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">846</key><key app="ENWeb" db-id="TWVFEgrtqgcAAHXhYvY">735</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Liberopoulos, E.</author><author>Karabina, S.A.</author><author>Tselepis, A.</author><author>Bairaktari, E.</author><author>Nicolaides, C.</author><author>Pavlidis, N.</author><author>Elisaf, M.</author></authors></contributors><auth-address>Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece.</auth-address><titles><title>Are the effects of tamoxifen on the serum lipid profile modified by apolipoprotein E phenotypes?</title><secondary-title>Oncology</secondary-title><alt-title>Oncology</alt-title></titles><periodical><full-title>Oncology</full-title><abbr-1>Oncology</abbr-1></periodical><alt-periodical><full-title>Oncology</full-title><abbr-1>Oncology</abbr-1></alt-periodical><pages>115-20</pages><volume>62</volume><number>2</number><keywords><keyword>Aged</keyword><keyword>Antineoplastic Agents, Hormonal/*pharmacology/therapeutic use</keyword><keyword>Apolipoproteins E/*genetics</keyword><keyword>Breast Neoplasms/*blood/drug therapy</keyword><keyword>Cholesterol, HDL/blood</keyword><keyword>Cholesterol, LDL/blood</keyword><keyword>Estrogen Receptor Modulators/*pharmacology/therapeutic use</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Lipids/*blood</keyword><keyword>Middle Aged</keyword><keyword>Phenotype</keyword><keyword>Postmenopause/*blood</keyword><keyword>Tamoxifen/*pharmacology/therapeutic use</keyword><keyword>Triglycerides/blood</keyword></keywords><dates><year>2002</year></dates><isbn>0030-2414 (Print)</isbn><accession-num>11914596</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=11914596</url></related-urls></urls><language>eng</language></record></Cite></EndNote>�D<EndNote><Cite><Author>Liberopoulos</Author><Year>2002</Year><RecNum>846</RecNum><DisplayText>[58]</DisplayText><record><rec-number>846</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">846</key><key app="ENWeb" db-id="TWVFEgrtqgcAAHXhYvY">735</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Liberopoulos, E.</author><author>Karabina, S.A.</author><author>Tselepis, A.</author><author>Bairaktari, E.</author><author>Nicolaides, C.</author><author>Pavlidis, N.</author><author>Elisaf, M.</author></authors></contributors><auth-address>Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece.</auth-address><titles><title>Are the effects of tamoxifen on the serum lipid profile modified by apolipoprotein E phenotypes?</title><secondary-title>Oncology</secondary-title><alt-title>Oncology</alt-title></titles><periodical><full-title>Oncology</full-title><abbr-1>Oncology</abbr-1></periodical><alt-periodical><full-title>Oncology</full-title><abbr-1>Oncology</abbr-1></alt-periodical><pages>115-20</pages><volume>62</volume><number>2</number><keywords><keyword>Aged</keyword><keyword>Antineoplastic Agents, Hormonal/*pharmacology/therapeutic use</keyword><keyword>Apolipoproteins E/*genetics</keyword><keyword>Breast Neoplasms/*blood/drug therapy</keyword><keyword>Cholesterol, HDL/blood</keyword><keyword>Cholesterol, LDL/blood</keyword><keyword>Estrogen Receptor Modulators/*pharmacology/therapeutic use</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Lipids/*blood</keyword><keyword>Middle Aged</keyword><keyword>Phenotype</keyword><keyword>Postmenopause/*blood</keyword><keyword>Tamoxifen/*pharmacology/therapeutic use</keyword><keyword>Triglycerides/blood</keyword></keywords><dates><year>2002</year></dates><isbn>0030-2414 (Print)</isbn><accession-num>11914596</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=11914596</url></related-urls></urls><language>eng</language></record></Cite></EndNote><D<EndNote><Cite><Author>Sozio</Author><Year>2012</Year><RecNum>2815</RecNum><DisplayText>[61, 62]</DisplayText><record><rec-number>2815</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2815</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sozio, P.</author><author>Cerasa, L. S.</author><author>Marinelli, L.</author><author>Di Stefano, A.</author></authors></contributors><auth-address>Department of Pharmacy, University of &quot;G. d&apos;Annunzio,&quot; Vai dei Vestini, Chieti, Italy.</auth-address><titles><title>Transdermal donepezil on the treatment of Alzheimer&apos;s disease</title><secondary-title>Neuropsychiatr Dis Treat</secondary-title></titles><periodical><full-title>Neuropsychiatr Dis Treat</full-title></periodical><pages>361-8</pages><volume>8</volume><edition>2012/09/04</edition><dates><year>2012</year></dates><isbn>1178-2021 (Electronic)&#xD;1176-6328 (Linking)</isbn><accession-num>22942647</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=22942647</url></related-urls></urls><electronic-resource-num>10.2147/NDT.S16089&#xD;ndt-8-361 [pii]</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Kurz</Author><Year>2009</Year><RecNum>2824</RecNum><record><rec-number>2824</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2824</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kurz, A.</author><author>Farlow, M.</author><author>Lefevre, G.</author></authors></contributors><auth-address>Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany. alexander.kurz@lrz.tumuenchen.de</auth-address><titles><title>Pharmacokinetics of a novel transdermal rivastigmine patch for the treatment of Alzheimer&apos;s disease: a review</title><secondary-title>Int J Clin Pract</secondary-title></titles><periodical><full-title>Int J Clin Pract</full-title></periodical><pages>799-805</pages><volume>63</volume><number>5</number><edition>2009/04/28</edition><keywords><keyword>Administration, Cutaneous</keyword><keyword>Alzheimer Disease/*drug therapy</keyword><keyword>Biological Availability</keyword><keyword>Cholinesterase Inhibitors/administration &amp; dosage/*pharmacokinetics</keyword><keyword>Humans</keyword><keyword>Phenylcarbamates/administration &amp; dosage/*pharmacokinetics</keyword><keyword>Treatment Outcome</keyword></keywords><dates><year>2009</year><pub-dates><date>May</date></pub-dates></dates><isbn>1742-1241 (Electronic)&#xD;1368-5031 (Linking)</isbn><accession-num>19392927</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=19392927</url></related-urls></urls><electronic-resource-num>IJCP2052 [pii]&#xD;10.1111/j.1742-1241.2009.02052.x</electronic-resource-num><language>eng</language></record></Cite></EndNote><D<EndNote><Cite><Author>Sozio</Author><Year>2012</Year><RecNum>2815</RecNum><DisplayText>[61, 62]</DisplayText><record><rec-number>2815</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2815</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sozio, P.</author><author>Cerasa, L. S.</author><author>Marinelli, L.</author><author>Di Stefano, A.</author></authors></contributors><auth-address>Department of Pharmacy, University of &quot;G. d&apos;Annunzio,&quot; Vai dei Vestini, Chieti, Italy.</auth-address><titles><title>Transdermal donepezil on the treatment of Alzheimer&apos;s disease</title><secondary-title>Neuropsychiatr Dis Treat</secondary-title></titles><periodical><full-title>Neuropsychiatr Dis Treat</full-title></periodical><pages>361-8</pages><volume>8</volume><edition>2012/09/04</edition><dates><year>2012</year></dates><isbn>1178-2021 (Electronic)&#xD;1176-6328 (Linking)</isbn><accession-num>22942647</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=22942647</url></related-urls></urls><electronic-resource-num>10.2147/NDT.S16089&#xD;ndt-8-361 [pii]</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Kurz</Author><Year>2009</Year><RecNum>2824</RecNum><record><rec-number>2824</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2824</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kurz, A.</author><author>Farlow, M.</author><author>Lefevre, G.</author></authors></contributors><auth-address>Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany. alexander.kurz@lrz.tumuenchen.de</auth-address><titles><title>Pharmacokinetics of a novel transdermal rivastigmine patch for the treatment of Alzheimer&apos;s disease: a review</title><secondary-title>Int J Clin Pract</secondary-title></titles><periodical><full-title>Int J Clin Pract</full-title></periodical><pages>799-805</pages><volume>63</volume><number>5</number><edition>2009/04/28</edition><keywords><keyword>Administration, Cutaneous</keyword><keyword>Alzheimer Disease/*drug therapy</keyword><keyword>Biological Availability</keyword><keyword>Cholinesterase Inhibitors/administration &amp; dosage/*pharmacokinetics</keyword><keyword>Humans</keyword><keyword>Phenylcarbamates/administration &amp; dosage/*pharmacokinetics</keyword><keyword>Treatment Outcome</keyword></keywords><dates><year>2009</year><pub-dates><date>May</date></pub-dates></dates><isbn>1742-1241 (Electronic)&#xD;1368-5031 (Linking)</isbn><accession-num>19392927</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=19392927</url></related-urls></urls><electronic-resource-num>IJCP2052 [pii]&#xD;10.1111/j.1742-1241.2009.02052.x</electronic-resource-num><language>eng</language></record></Cite></EndNote><D<EndNote><Cite><Author>Sozio</Author><Year>2012</Year><RecNum>2815</RecNum><DisplayText>[61, 62]</DisplayText><record><rec-number>2815</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2815</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sozio, P.</author><author>Cerasa, L. S.</author><author>Marinelli, L.</author><author>Di Stefano, A.</author></authors></contributors><auth-address>Department of Pharmacy, University of &quot;G. d&apos;Annunzio,&quot; Vai dei Vestini, Chieti, Italy.</auth-address><titles><title>Transdermal donepezil on the treatment of Alzheimer&apos;s disease</title><secondary-title>Neuropsychiatr Dis Treat</secondary-title></titles><periodical><full-title>Neuropsychiatr Dis Treat</full-title></periodical><pages>361-8</pages><volume>8</volume><edition>2012/09/04</edition><dates><year>2012</year></dates><isbn>1178-2021 (Electronic)&#xD;1176-6328 (Linking)</isbn><accession-num>22942647</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=22942647</url></related-urls></urls><electronic-resource-num>10.2147/NDT.S16089&#xD;ndt-8-361 [pii]</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Kurz</Author><Year>2009</Year><RecNum>2824</RecNum><record><rec-number>2824</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2824</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kurz, A.</author><author>Farlow, M.</author><author>Lefevre, G.</author></authors></contributors><auth-address>Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany. alexander.kurz@lrz.tumuenchen.de</auth-address><titles><title>Pharmacokinetics of a novel transdermal rivastigmine patch for the treatment of Alzheimer&apos;s disease: a review</title><secondary-title>Int J Clin Pract</secondary-title></titles><periodical><full-title>Int J Clin Pract</full-title></periodical><pages>799-805</pages><volume>63</volume><number>5</number><edition>2009/04/28</edition><keywords><keyword>Administration, Cutaneous</keyword><keyword>Alzheimer Disease/*drug therapy</keyword><keyword>Biological Availability</keyword><keyword>Cholinesterase Inhibitors/administration &amp; dosage/*pharmacokinetics</keyword><keyword>Humans</keyword><keyword>Phenylcarbamates/administration &amp; dosage/*pharmacokinetics</keyword><keyword>Treatment Outcome</keyword></keywords><dates><year>2009</year><pub-dates><date>May</date></pub-dates></dates><isbn>1742-1241 (Electronic)&#xD;1368-5031 (Linking)</isbn><accession-num>19392927</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=19392927</url></related-urls></urls><electronic-resource-num>IJCP2052 [pii]&#xD;10.1111/j.1742-1241.2009.02052.x</electronic-resource-num><language>eng</language></record></Cite></EndNote><D<EndNote><Cite><Author>Sozio</Author><Year>2012</Year><RecNum>2815</RecNum><DisplayText>[61, 62]</DisplayText><record><rec-number>2815</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2815</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sozio, P.</author><author>Cerasa, L. S.</author><author>Marinelli, L.</author><author>Di Stefano, A.</author></authors></contributors><auth-address>Department of Pharmacy, University of &quot;G. d&apos;Annunzio,&quot; Vai dei Vestini, Chieti, Italy.</auth-address><titles><title>Transdermal donepezil on the treatment of Alzheimer&apos;s disease</title><secondary-title>Neuropsychiatr Dis Treat</secondary-title></titles><periodical><full-title>Neuropsychiatr Dis Treat</full-title></periodical><pages>361-8</pages><volume>8</volume><edition>2012/09/04</edition><dates><year>2012</year></dates><isbn>1178-2021 (Electronic)&#xD;1176-6328 (Linking)</isbn><accession-num>22942647</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=22942647</url></related-urls></urls><electronic-resource-num>10.2147/NDT.S16089&#xD;ndt-8-361 [pii]</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Kurz</Author><Year>2009</Year><RecNum>2824</RecNum><record><rec-number>2824</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2824</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kurz, A.</author><author>Farlow, M.</author><author>Lefevre, G.</author></authors></contributors><auth-address>Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany. alexander.kurz@lrz.tumuenchen.de</auth-address><titles><title>Pharmacokinetics of a novel transdermal rivastigmine patch for the treatment of Alzheimer&apos;s disease: a review</title><secondary-title>Int J Clin Pract</secondary-title></titles><periodical><full-title>Int J Clin Pract</full-title></periodical><pages>799-805</pages><volume>63</volume><number>5</number><edition>2009/04/28</edition><keywords><keyword>Administration, Cutaneous</keyword><keyword>Alzheimer Disease/*drug therapy</keyword><keyword>Biological Availability</keyword><keyword>Cholinesterase Inhibitors/administration &amp; dosage/*pharmacokinetics</keyword><keyword>Humans</keyword><keyword>Phenylcarbamates/administration &amp; dosage/*pharmacokinetics</keyword><keyword>Treatment Outcome</keyword></keywords><dates><year>2009</year><pub-dates><date>May</date></pub-dates></dates><isbn>1742-1241 (Electronic)&#xD;1368-5031 (Linking)</isbn><accession-num>19392927</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=19392927</url></related-urls></urls><electronic-resource-num>IJCP2052 [pii]&#xD;10.1111/j.1742-1241.2009.02052.x</electronic-resource-num><language>eng</language></record></Cite></EndNote>fD<EndNote><Cite><Author>Zhang</Author><Year>2004</Year><RecNum>2820</RecNum><DisplayText>[63]</DisplayText><record><rec-number>2820</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2820</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Zhang, L.</author><author>Plotkin, R. C.</author><author>Wang, G.</author><author>Sandel, M. E.</author><author>Lee, S.</author></authors></contributors><auth-address>Department of Rehabilitation Medicine, University of Texas Health Science Center, San Antonio, TX, USA. neurorehab@yahoo.com</auth-address><titles><title>Cholinergic augmentation with donepezil enhances recovery in short-term memory and sustained attention after traumatic brain injury</title><secondary-title>Arch Phys Med Rehabil</secondary-title></titles><periodical><full-title>Arch Phys Med Rehabil</full-title></periodical><pages>1050-5</pages><volume>85</volume><number>7</number><edition>2004/07/09</edition><keywords><keyword>Adult</keyword><keyword>Attention/*drug effects</keyword><keyword>Brain Injuries/*rehabilitation</keyword><keyword>Cholinesterase Inhibitors/*pharmacology/therapeutic use</keyword><keyword>Cognition/*drug effects</keyword><keyword>Cross-Over Studies</keyword><keyword>Double-Blind Method</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Indans/*pharmacology/therapeutic use</keyword><keyword>Male</keyword><keyword>Memory/*drug effects</keyword><keyword>Middle Aged</keyword><keyword>Neuropsychological Tests</keyword><keyword>Piperidines/*pharmacology/therapeutic use</keyword></keywords><dates><year>2004</year><pub-dates><date>Jul</date></pub-dates></dates><isbn>0003-9993 (Print)&#xD;0003-9993 (Linking)</isbn><accession-num>15241749</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=15241749</url></related-urls></urls><electronic-resource-num>S0003999304000115 [pii]</electronic-resource-num><language>eng</language></record></Cite></EndNote>fD<EndNote><Cite><Author>Zhang</Author><Year>2004</Year><RecNum>2820</RecNum><DisplayText>[63]</DisplayText><record><rec-number>2820</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2820</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Zhang, L.</author><author>Plotkin, R. C.</author><author>Wang, G.</author><author>Sandel, M. E.</author><author>Lee, S.</author></authors></contributors><auth-address>Department of Rehabilitation Medicine, University of Texas Health Science Center, San Antonio, TX, USA. neurorehab@yahoo.com</auth-address><titles><title>Cholinergic augmentation with donepezil enhances recovery in short-term memory and sustained attention after traumatic brain injury</title><secondary-title>Arch Phys Med Rehabil</secondary-title></titles><periodical><full-title>Arch Phys Med Rehabil</full-title></periodical><pages>1050-5</pages><volume>85</volume><number>7</number><edition>2004/07/09</edition><keywords><keyword>Adult</keyword><keyword>Attention/*drug effects</keyword><keyword>Brain Injuries/*rehabilitation</keyword><keyword>Cholinesterase Inhibitors/*pharmacology/therapeutic use</keyword><keyword>Cognition/*drug effects</keyword><keyword>Cross-Over Studies</keyword><keyword>Double-Blind Method</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Indans/*pharmacology/therapeutic use</keyword><keyword>Male</keyword><keyword>Memory/*drug effects</keyword><keyword>Middle Aged</keyword><keyword>Neuropsychological Tests</keyword><keyword>Piperidines/*pharmacology/therapeutic use</keyword></keywords><dates><year>2004</year><pub-dates><date>Jul</date></pub-dates></dates><isbn>0003-9993 (Print)&#xD;0003-9993 (Linking)</isbn><accession-num>15241749</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=15241749</url></related-urls></urls><electronic-resource-num>S0003999304000115 [pii]</electronic-resource-num><language>eng</language></record></Cite></EndNote>N	D<EndNote><Cite><Author>Shaw</Author><Year>2006</Year><RecNum>2821</RecNum><DisplayText>[64]</DisplayText><record><rec-number>2821</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2821</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Shaw, E. G.</author><author>Rosdhal, R.</author><author>D&apos;Agostino, R. B., Jr.</author><author>Lovato, J.</author><author>Naughton, M. J.</author><author>Robbins, M. E.</author><author>Rapp, S. R.</author></authors></contributors><auth-address>Department of Radiation Oncology, Wake Forest University School of Medicine, Brain Tumor Center of Excellence of WFU, Winston-Salem, NC 27157-1030, USA. eshaw@wfubmc.edu</auth-address><titles><title>Phase II study of donepezil in irradiated brain tumor patients: effect on cognitive function, mood, and quality of life</title><secondary-title>J Clin Oncol</secondary-title></titles><periodical><full-title>J Clin Oncol</full-title></periodical><pages>1415-20</pages><volume>24</volume><number>9</number><edition>2006/03/22</edition><keywords><keyword>Adult</keyword><keyword>Affect/*drug effects</keyword><keyword>Aged</keyword><keyword>Anger</keyword><keyword>Brain Neoplasms/*drug therapy/radiotherapy</keyword><keyword>Cholinesterase Inhibitors/*therapeutic use</keyword><keyword>Cognition Disorders/*drug therapy/etiology</keyword><keyword>Fatigue</keyword><keyword>Female</keyword><keyword>Glioma/*drug therapy/radiotherapy</keyword><keyword>Humans</keyword><keyword>Indans/*therapeutic use</keyword><keyword>Male</keyword><keyword>Memory</keyword><keyword>Middle Aged</keyword><keyword>Piperidines/*therapeutic use</keyword><keyword>Prospective Studies</keyword><keyword>Quality of Life</keyword><keyword>Radiation Injuries/*drug therapy</keyword></keywords><dates><year>2006</year><pub-dates><date>Mar 20</date></pub-dates></dates><isbn>1527-7755 (Electronic)&#xD;0732-183X (Linking)</isbn><accession-num>16549835</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16549835</url></related-urls></urls><electronic-resource-num>24/9/1415 [pii]&#xD;10.1200/JCO.2005.03.3001</electronic-resource-num><language>eng</language></record></Cite></EndNote>N	D<EndNote><Cite><Author>Shaw</Author><Year>2006</Year><RecNum>2821</RecNum><DisplayText>[64]</DisplayText><record><rec-number>2821</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2821</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Shaw, E. 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R.</author></authors></contributors><auth-address>Department of Radiation Oncology, Wake Forest University School of Medicine, Brain Tumor Center of Excellence of WFU, Winston-Salem, NC 27157-1030, USA. eshaw@wfubmc.edu</auth-address><titles><title>Phase II study of donepezil in irradiated brain tumor patients: effect on cognitive function, mood, and quality of life</title><secondary-title>J Clin Oncol</secondary-title></titles><periodical><full-title>J Clin Oncol</full-title></periodical><pages>1415-20</pages><volume>24</volume><number>9</number><edition>2006/03/22</edition><keywords><keyword>Adult</keyword><keyword>Affect/*drug effects</keyword><keyword>Aged</keyword><keyword>Anger</keyword><keyword>Brain Neoplasms/*drug therapy/radiotherapy</keyword><keyword>Cholinesterase Inhibitors/*therapeutic use</keyword><keyword>Cognition Disorders/*drug therapy/etiology</keyword><keyword>Fatigue</keyword><keyword>Female</keyword><keyword>Glioma/*drug therapy/radiotherapy</keyword><keyword>Humans</keyword><keyword>Indans/*therapeutic use</keyword><keyword>Male</keyword><keyword>Memory</keyword><keyword>Middle Aged</keyword><keyword>Piperidines/*therapeutic use</keyword><keyword>Prospective Studies</keyword><keyword>Quality of Life</keyword><keyword>Radiation Injuries/*drug therapy</keyword></keywords><dates><year>2006</year><pub-dates><date>Mar 20</date></pub-dates></dates><isbn>1527-7755 (Electronic)&#xD;0732-183X (Linking)</isbn><accession-num>16549835</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16549835</url></related-urls></urls><electronic-resource-num>24/9/1415 [pii]&#xD;10.1200/JCO.2005.03.3001</electronic-resource-num><language>eng</language></record></Cite></EndNote>:
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V., Jr.</author></authors></contributors><auth-address>Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy, Medical College of Georgia, Augusta, 30912, USA.</auth-address><titles><title>Comparison of galantamine and donepezil for effects on nerve growth factor, cholinergic markers, and memory performance in aged rats</title><secondary-title>J Pharmacol Exp Ther</secondary-title></titles><periodical><full-title>J Pharmacol Exp Ther</full-title><abbr-1>The Journal of pharmacology and experimental therapeutics</abbr-1></periodical><pages>679-94</pages><volume>316</volume><number>2</number><edition>2005/10/11</edition><keywords><keyword>Acetylcholinesterase/blood</keyword><keyword>Aging/drug effects/*metabolism</keyword><keyword>Animals</keyword><keyword>Autoradiography</keyword><keyword>Brain/drug effects/enzymology/metabolism</keyword><keyword>Choline O-Acetyltransferase/metabolism</keyword><keyword>Cholinesterase Inhibitors/administration &amp; dosage/*pharmacology</keyword><keyword>Enzyme-Linked Immunosorbent Assay</keyword><keyword>Galantamine/administration &amp; dosage/*pharmacology</keyword><keyword>Indans/administration &amp; dosage/*pharmacology</keyword><keyword>Injections, Subcutaneous</keyword><keyword>Male</keyword><keyword>Maze Learning/drug effects</keyword><keyword>Memory/*drug effects</keyword><keyword>Motor Activity/drug effects</keyword><keyword>Nerve Growth Factor/*metabolism</keyword><keyword>Piperidines/administration &amp; dosage/*pharmacology</keyword><keyword>Rats</keyword><keyword>Rats, Inbred F344</keyword><keyword>Receptors, Cholinergic/*metabolism</keyword><keyword>Vesicular Acetylcholine Transport Proteins/metabolism</keyword></keywords><dates><year>2006</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>0022-3565 (Print)&#xD;0022-3565 (Linking)</isbn><accession-num>16214877</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16214877</url></related-urls></urls><electronic-resource-num>jpet.105.093047 [pii]&#xD;10.1124/jpet.105.093047</electronic-resource-num><language>eng</language></record></Cite></EndNote>	D<EndNote><Cite><Author>Bruera</Author><Year>2007</Year><RecNum>2825</RecNum><DisplayText>[68]</DisplayText><record><rec-number>2825</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2825</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bruera, E.</author><author>El Osta, B.</author><author>Valero, V.</author><author>Driver, L. 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L.</author></authors></contributors><auth-address>Department of Palliative Care and Rehabilitation Medicine, Unit 008, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. ebruera@mdanderson.org</auth-address><titles><title>Donepezil for cancer fatigue: a double-blind, randomized, placebo-controlled trial</title><secondary-title>J Clin Oncol</secondary-title><alt-title>Journal of Clinical Oncology</alt-title></titles><periodical><full-title>J Clin Oncol</full-title></periodical><alt-periodical><full-title>Journal of Clinical Oncology</full-title></alt-periodical><pages>3475-81</pages><volume>25</volume><number>23</number><edition>2007/08/10</edition><keywords><keyword>Aged</keyword><keyword>Disease Progression</keyword><keyword>Double-Blind Method</keyword><keyword>Fatigue/*drug therapy</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Indans/*therapeutic use</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Neoplasms/*complications</keyword><keyword>Nootropic Agents/*therapeutic use</keyword><keyword>Piperidines/*therapeutic use</keyword><keyword>Placebos</keyword><keyword>Telemedicine</keyword><keyword>Time Factors</keyword><keyword>Treatment Outcome</keyword></keywords><dates><year>2007</year><pub-dates><date>Aug 10</date></pub-dates></dates><isbn>1527-7755 (Electronic)&#xD;0732-183X (Linking)</isbn><accession-num>17687152</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=17687152</url></related-urls></urls><electronic-resource-num>25/23/3475 [pii]&#xD;10.1200/JCO.2007.10.9231</electronic-resource-num><language>eng</language></record></Cite></EndNote>	D<EndNote><Cite><Author>Bruera</Author><Year>2007</Year><RecNum>2825</RecNum><DisplayText>[68]</DisplayText><record><rec-number>2825</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2825</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bruera, E.</author><author>El Osta, B.</author><author>Valero, V.</author><author>Driver, L. 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G.</author><author>Cruts, M.</author><author>Adolfsson, R.</author><author>Van Broeckhoven, C.</author><author>Nyberg, L.</author></authors></contributors><auth-address>Department of Psychology, Umea University, S-901 87 Umea, Sweden. anna.sundstrom@psy.umu.se</auth-address><titles><title>Fatigue before and after mild traumatic brain injury: pre-post-injury comparisons in relation to Apolipoprotein E</title><secondary-title>Brain Inj</secondary-title><alt-title>Brain Injury</alt-title></titles><periodical><full-title>Brain Inj</full-title></periodical><pages>1049-54</pages><volume>21</volume><number>10</number><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Anxiety Disorders/epidemiology/etiology</keyword><keyword>Apolipoprotein E4/genetics</keyword><keyword>Apolipoproteins E/*genetics</keyword><keyword>Brain Injuries/complications/*epidemiology</keyword><keyword>Case-Control Studies</keyword><keyword>Chronic Disease</keyword><keyword>Depressive Disorder/epidemiology/etiology</keyword><keyword>Fatigue/*epidemiology/etiology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Longitudinal Studies</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Phenotype</keyword><keyword>Prospective Studies</keyword><keyword>Sleep Disorders/epidemiology/etiology</keyword><keyword>Sweden/epidemiology</keyword></keywords><dates><year>2007</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>0269-9052 (Print)&#xD;0269-9052 (Linking)</isbn><accession-num>17891567</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/17891567</url></related-urls></urls><electronic-resource-num>10.1080/02699050701630367</electronic-resource-num></record></Cite></EndNote>	D<EndNote><Cite><Author>Bizzarro</Author><Year>2005</Year><RecNum>2335</RecNum><DisplayText>[70]</DisplayText><record><rec-number>2335</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2335</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bizzarro, A.</author><author>Marra, C.</author><author>Acciarri, A.</author><author>Valenza, A.</author><author>Tiziano, F. D.</author><author>Brahe, C.</author><author>Masullo, C.</author></authors></contributors><auth-address>Institutes of Neurology, Catholic University of Sacred Heart, School of Medicine, University Hospital A. Gemelli, IT-00168 Rome, Italy.</auth-address><titles><title>Apolipoprotein E epsilon4 allele differentiates the clinical response to donepezil in Alzheimer&apos;s disease</title><secondary-title>Dement Geriatr Cogn Disord</secondary-title></titles><periodical><full-title>Dement Geriatr Cogn Disord</full-title></periodical><pages>254-61</pages><volume>20</volume><number>4</number><edition>2005/08/17</edition><keywords><keyword>Aged</keyword><keyword>Alleles</keyword><keyword>Alzheimer Disease/*drug therapy/*genetics/psychology</keyword><keyword>Apolipoprotein E4</keyword><keyword>Apolipoproteins E/*genetics</keyword><keyword>Attention/physiology</keyword><keyword>Cholinesterase Inhibitors/*therapeutic use</keyword><keyword>Cognition/physiology</keyword><keyword>Education</keyword><keyword>Female</keyword><keyword>Gene Frequency</keyword><keyword>Genotype</keyword><keyword>Humans</keyword><keyword>Indans/*therapeutic use</keyword><keyword>Intelligence Tests</keyword><keyword>Language</keyword><keyword>Male</keyword><keyword>Neuropsychological Tests</keyword><keyword>Piperidines/*therapeutic use</keyword><keyword>Retrospective Studies</keyword></keywords><dates><year>2005</year></dates><isbn>1420-8008 (Print)&#xD;1420-8008 (Linking)</isbn><accession-num>16103669</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16103669</url></related-urls></urls><electronic-resource-num>87371 [pii]&#xD;10.1159/000087371</electronic-resource-num><language>eng</language></record></Cite></EndNote>	D<EndNote><Cite><Author>Bizzarro</Author><Year>2005</Year><RecNum>2335</RecNum><DisplayText>[70]</DisplayText><record><rec-number>2335</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2335</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bizzarro, A.</author><author>Marra, C.</author><author>Acciarri, A.</author><author>Valenza, A.</author><author>Tiziano, F. D.</author><author>Brahe, C.</author><author>Masullo, C.</author></authors></contributors><auth-address>Institutes of Neurology, Catholic University of Sacred Heart, School of Medicine, University Hospital A. Gemelli, IT-00168 Rome, Italy.</auth-address><titles><title>Apolipoprotein E epsilon4 allele differentiates the clinical response to donepezil in Alzheimer&apos;s disease</title><secondary-title>Dement Geriatr Cogn Disord</secondary-title></titles><periodical><full-title>Dement Geriatr Cogn Disord</full-title></periodical><pages>254-61</pages><volume>20</volume><number>4</number><edition>2005/08/17</edition><keywords><keyword>Aged</keyword><keyword>Alleles</keyword><keyword>Alzheimer Disease/*drug therapy/*genetics/psychology</keyword><keyword>Apolipoprotein E4</keyword><keyword>Apolipoproteins E/*genetics</keyword><keyword>Attention/physiology</keyword><keyword>Cholinesterase Inhibitors/*therapeutic use</keyword><keyword>Cognition/physiology</keyword><keyword>Education</keyword><keyword>Female</keyword><keyword>Gene Frequency</keyword><keyword>Genotype</keyword><keyword>Humans</keyword><keyword>Indans/*therapeutic use</keyword><keyword>Intelligence Tests</keyword><keyword>Language</keyword><keyword>Male</keyword><keyword>Neuropsychological Tests</keyword><keyword>Piperidines/*therapeutic use</keyword><keyword>Retrospective Studies</keyword></keywords><dates><year>2005</year></dates><isbn>1420-8008 (Print)&#xD;1420-8008 (Linking)</isbn><accession-num>16103669</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16103669</url></related-urls></urls><electronic-resource-num>87371 [pii]&#xD;10.1159/000087371</electronic-resource-num><language>eng</language></record></Cite></EndNote>�	D<EndNote><Cite><Author>Jack</Author><Year>2008</Year><RecNum>2819</RecNum><DisplayText>[71]</DisplayText><record><rec-number>2819</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2819</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Jack, C. R., Jr.</author><author>Petersen, R. C.</author><author>Grundman, M.</author><author>Jin, S.</author><author>Gamst, A.</author><author>Ward, C. P.</author><author>Sencakova, D.</author><author>Doody, R. S.</author><author>Thal, L. J.</author></authors></contributors><auth-address>Department of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA. jack.clifford@mayo.edu</auth-address><titles><title>Longitudinal MRI findings from the vitamin E and donepezil treatment study for MCI</title><secondary-title>Neurobiol Aging</secondary-title></titles><periodical><full-title>Neurobiol Aging</full-title></periodical><pages>1285-95</pages><volume>29</volume><number>9</number><edition>2007/04/25</edition><keywords><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Antioxidants/administration &amp; dosage</keyword><keyword>Atrophy/drug therapy/epidemiology/pathology</keyword><keyword>Cholinesterase Inhibitors/administration &amp; dosage</keyword><keyword>Cognition Disorders/*drug therapy/epidemiology/*pathology</keyword><keyword>Female</keyword><keyword>Hippocampus/drug effects/*pathology</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Indans/*administration &amp; dosage</keyword><keyword>Longitudinal Studies</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Piperidines/*administration &amp; dosage</keyword><keyword>Treatment Outcome</keyword><keyword>United States/epidemiology</keyword><keyword>Vitamin E/*administration &amp; dosage</keyword></keywords><dates><year>2008</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>1558-1497 (Electronic)&#xD;0197-4580 (Linking)</isbn><accession-num>17452062</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=17452062</url></related-urls></urls><electronic-resource-num>S0197-4580(07)00114-5 [pii]&#xD;10.1016/j.neurobiolaging.2007.03.004</electronic-resource-num><language>eng</language></record></Cite></EndNote>�	D<EndNote><Cite><Author>Jack</Author><Year>2008</Year><RecNum>2819</RecNum><DisplayText>[71]</DisplayText><record><rec-number>2819</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2819</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Jack, C. R., Jr.</author><author>Petersen, R. C.</author><author>Grundman, M.</author><author>Jin, S.</author><author>Gamst, A.</author><author>Ward, C. P.</author><author>Sencakova, D.</author><author>Doody, R. S.</author><author>Thal, L. J.</author></authors></contributors><auth-address>Department of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA. jack.clifford@mayo.edu</auth-address><titles><title>Longitudinal MRI findings from the vitamin E and donepezil treatment study for MCI</title><secondary-title>Neurobiol Aging</secondary-title></titles><periodical><full-title>Neurobiol Aging</full-title></periodical><pages>1285-95</pages><volume>29</volume><number>9</number><edition>2007/04/25</edition><keywords><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Antioxidants/administration &amp; dosage</keyword><keyword>Atrophy/drug therapy/epidemiology/pathology</keyword><keyword>Cholinesterase Inhibitors/administration &amp; dosage</keyword><keyword>Cognition Disorders/*drug therapy/epidemiology/*pathology</keyword><keyword>Female</keyword><keyword>Hippocampus/drug effects/*pathology</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Indans/*administration &amp; dosage</keyword><keyword>Longitudinal Studies</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Piperidines/*administration &amp; dosage</keyword><keyword>Treatment Outcome</keyword><keyword>United States/epidemiology</keyword><keyword>Vitamin E/*administration &amp; dosage</keyword></keywords><dates><year>2008</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>1558-1497 (Electronic)&#xD;0197-4580 (Linking)</isbn><accession-num>17452062</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=17452062</url></related-urls></urls><electronic-resource-num>S0197-4580(07)00114-5 [pii]&#xD;10.1016/j.neurobiolaging.2007.03.004</electronic-resource-num><language>eng</language></record></Cite></EndNote>�D<EndNote><Cite><Author>Lyons</Author><Year>2012</Year><RecNum>2327</RecNum><DisplayText>[73-75]</DisplayText><record><rec-number>2327</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2327</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lyons, L.</author><author>ElBeltagy, M.</author><author>Bennett, G.</author><author>Wigmore, P.</author></authors></contributors><auth-address>School of Biomedical Sciences, University of Nottingham, Nottingham, United Kingdom.</auth-address><titles><title>Fluoxetine counteracts the cognitive and cellular effects of 5-fluorouracil in the rat hippocampus by a mechanism of prevention rather than recovery</title><secondary-title>PLoS One</secondary-title></titles><periodical><full-title>PLoS One</full-title></periodical><pages>e30010</pages><volume>7</volume><number>1</number><edition>2012/01/25</edition><dates><year>2012</year></dates><isbn>1932-6203 (Electronic)&#xD;1932-6203 (Linking)</isbn><accession-num>22272269</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=22272269</url></related-urls></urls><electronic-resource-num>10.1371/journal.pone.0030010&#xD;PONE-D-11-09364 [pii]</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Marcussen</Author><Year>2008</Year><RecNum>2342</RecNum><record><rec-number>2342</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2342</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Marcussen, A. B.</author><author>Flagstad, P.</author><author>Kristjansen, P. E.</author><author>Johansen, F. F.</author><author>Englund, U.</author></authors></contributors><auth-address>Department of Pharmacology Target Research, H. Lundbeck A/S, Valby, Denmark.</auth-address><titles><title>Increase in neurogenesis and behavioural benefit after chronic fluoxetine treatment in Wistar rats</title><secondary-title>Acta Neurol Scand</secondary-title></titles><periodical><full-title>Acta Neurol Scand</full-title></periodical><pages>94-100</pages><volume>117</volume><number>2</number><edition>2008/01/11</edition><keywords><keyword>Animals</keyword><keyword>Behavior, Animal/*drug effects</keyword><keyword>Bromodeoxyuridine/metabolism</keyword><keyword>Cell Count</keyword><keyword>Cell Proliferation/*drug effects</keyword><keyword>Dentate Gyrus/cytology</keyword><keyword>Drug Administration Schedule</keyword><keyword>Feeding Behavior/drug effects</keyword><keyword>Fluoxetine/*administration &amp; dosage</keyword><keyword>Ki-67 Antigen/metabolism</keyword><keyword>Male</keyword><keyword>Microtubule-Associated Proteins/metabolism</keyword><keyword>Neurons/*drug effects</keyword><keyword>Neuropeptides/metabolism</keyword><keyword>Rats</keyword><keyword>Rats, Wistar</keyword><keyword>Reaction Time/drug effects</keyword><keyword>Serotonin Uptake Inhibitors/*administration &amp; dosage</keyword></keywords><dates><year>2008</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1600-0404 (Electronic)&#xD;0001-6314 (Linking)</isbn><accession-num>18184344</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=18184344</url></related-urls></urls><electronic-resource-num>ANE910 [pii]&#xD;10.1111/j.1600-0404.2007.00910.x</electronic-resource-num><language>eng</language></record></Cite><Cite ExcludeYear="1"><Author>Zhang</Author><Year>2012</Year><RecNum>2802</RecNum><record><rec-number>2802</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2802</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Zhang, F.</author><author>Zhou, H.</author><author>Wilson, B. C.</author><author>Shi, J. S.</author><author>Hong, J. S.</author><author>Gao, H. M.</author></authors></contributors><auth-address>Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.</auth-address><titles><title>Fluoxetine protects neurons against microglial activation-mediated neurotoxicity</title><secondary-title>Parkinsonism Relat Disord</secondary-title></titles><periodical><full-title>Parkinsonism Relat Disord</full-title></periodical><pages>S213-7</pages><volume>18 Suppl 1</volume><edition>2011/12/23</edition><keywords><keyword>Animals</keyword><keyword>Cells, Cultured</keyword><keyword>Female</keyword><keyword>Fluoxetine/pharmacology/*therapeutic use</keyword><keyword>Microglia/*drug effects/*metabolism/pathology</keyword><keyword>NF-kappa B/antagonists &amp; inhibitors/metabolism</keyword><keyword>Neurons/*drug effects/metabolism/pathology</keyword><keyword>Neuroprotective Agents/pharmacology/*therapeutic use</keyword><keyword>Neurotoxicity Syndromes/metabolism/prevention &amp; control</keyword><keyword>Parkinson Disease/metabolism/*prevention &amp; control</keyword><keyword>Pregnancy</keyword><keyword>Rats</keyword><keyword>Rats, Inbred F344</keyword><keyword>Reactive Oxygen Species/metabolism</keyword></keywords><dates><year>2012</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>1873-5126 (Electronic)&#xD;1353-8020 (Linking)</isbn><accession-num>22166439</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=22166439</url></related-urls></urls><electronic-resource-num>S1353-8020(11)70066-9 [pii]&#xD;10.1016/S1353-8020(11)70066-9</electronic-resource-num><language>eng</language></record></Cite></EndNote>�D<EndNote><Cite><Author>Lyons</Author><Year>2012</Year><RecNum>2327</RecNum><DisplayText>[73-75]</DisplayText><record><rec-number>2327</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2327</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lyons, L.</author><author>ElBeltagy, M.</author><author>Bennett, G.</author><author>Wigmore, P.</author></authors></contributors><auth-address>School of Biomedical Sciences, University of Nottingham, Nottingham, United Kingdom.</auth-address><titles><title>Fluoxetine counteracts the cognitive and cellular effects of 5-fluorouracil in the rat hippocampus by a mechanism of prevention rather than recovery</title><secondary-title>PLoS One</secondary-title></titles><periodical><full-title>PLoS One</full-title></periodical><pages>e30010</pages><volume>7</volume><number>1</number><edition>2012/01/25</edition><dates><year>2012</year></dates><isbn>1932-6203 (Electronic)&#xD;1932-6203 (Linking)</isbn><accession-num>22272269</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=22272269</url></related-urls></urls><electronic-resource-num>10.1371/journal.pone.0030010&#xD;PONE-D-11-09364 [pii]</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Marcussen</Author><Year>2008</Year><RecNum>2342</RecNum><record><rec-number>2342</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2342</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Marcussen, A. B.</author><author>Flagstad, P.</author><author>Kristjansen, P. E.</author><author>Johansen, F. F.</author><author>Englund, U.</author></authors></contributors><auth-address>Department of Pharmacology Target Research, H. Lundbeck A/S, Valby, Denmark.</auth-address><titles><title>Increase in neurogenesis and behavioural benefit after chronic fluoxetine treatment in Wistar rats</title><secondary-title>Acta Neurol Scand</secondary-title></titles><periodical><full-title>Acta Neurol Scand</full-title></periodical><pages>94-100</pages><volume>117</volume><number>2</number><edition>2008/01/11</edition><keywords><keyword>Animals</keyword><keyword>Behavior, Animal/*drug effects</keyword><keyword>Bromodeoxyuridine/metabolism</keyword><keyword>Cell Count</keyword><keyword>Cell Proliferation/*drug effects</keyword><keyword>Dentate Gyrus/cytology</keyword><keyword>Drug Administration Schedule</keyword><keyword>Feeding Behavior/drug effects</keyword><keyword>Fluoxetine/*administration &amp; dosage</keyword><keyword>Ki-67 Antigen/metabolism</keyword><keyword>Male</keyword><keyword>Microtubule-Associated Proteins/metabolism</keyword><keyword>Neurons/*drug effects</keyword><keyword>Neuropeptides/metabolism</keyword><keyword>Rats</keyword><keyword>Rats, Wistar</keyword><keyword>Reaction Time/drug effects</keyword><keyword>Serotonin Uptake Inhibitors/*administration &amp; dosage</keyword></keywords><dates><year>2008</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1600-0404 (Electronic)&#xD;0001-6314 (Linking)</isbn><accession-num>18184344</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=18184344</url></related-urls></urls><electronic-resource-num>ANE910 [pii]&#xD;10.1111/j.1600-0404.2007.00910.x</electronic-resource-num><language>eng</language></record></Cite><Cite ExcludeYear="1"><Author>Zhang</Author><Year>2012</Year><RecNum>2802</RecNum><record><rec-number>2802</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2802</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Zhang, F.</author><author>Zhou, H.</author><author>Wilson, B. C.</author><author>Shi, J. S.</author><author>Hong, J. S.</author><author>Gao, H. M.</author></authors></contributors><auth-address>Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.</auth-address><titles><title>Fluoxetine protects neurons against microglial activation-mediated neurotoxicity</title><secondary-title>Parkinsonism Relat Disord</secondary-title></titles><periodical><full-title>Parkinsonism Relat Disord</full-title></periodical><pages>S213-7</pages><volume>18 Suppl 1</volume><edition>2011/12/23</edition><keywords><keyword>Animals</keyword><keyword>Cells, Cultured</keyword><keyword>Female</keyword><keyword>Fluoxetine/pharmacology/*therapeutic use</keyword><keyword>Microglia/*drug effects/*metabolism/pathology</keyword><keyword>NF-kappa B/antagonists &amp; inhibitors/metabolism</keyword><keyword>Neurons/*drug effects/metabolism/pathology</keyword><keyword>Neuroprotective Agents/pharmacology/*therapeutic use</keyword><keyword>Neurotoxicity Syndromes/metabolism/prevention &amp; control</keyword><keyword>Parkinson Disease/metabolism/*prevention &amp; control</keyword><keyword>Pregnancy</keyword><keyword>Rats</keyword><keyword>Rats, Inbred F344</keyword><keyword>Reactive Oxygen Species/metabolism</keyword></keywords><dates><year>2012</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>1873-5126 (Electronic)&#xD;1353-8020 (Linking)</isbn><accession-num>22166439</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=22166439</url></related-urls></urls><electronic-resource-num>S1353-8020(11)70066-9 [pii]&#xD;10.1016/S1353-8020(11)70066-9</electronic-resource-num><language>eng</language></record></Cite></EndNote>�D<EndNote><Cite><Author>Lyons</Author><Year>2012</Year><RecNum>2327</RecNum><DisplayText>[73, 77, 78]</DisplayText><record><rec-number>2327</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2327</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lyons, L.</author><author>ElBeltagy, M.</author><author>Bennett, G.</author><author>Wigmore, P.</author></authors></contributors><auth-address>School of Biomedical Sciences, University of Nottingham, Nottingham, United Kingdom.</auth-address><titles><title>Fluoxetine counteracts the cognitive and cellular effects of 5-fluorouracil in the rat hippocampus by a mechanism of prevention rather than recovery</title><secondary-title>PLoS One</secondary-title></titles><periodical><full-title>PLoS One</full-title></periodical><pages>e30010</pages><volume>7</volume><number>1</number><edition>2012/01/25</edition><dates><year>2012</year></dates><isbn>1932-6203 (Electronic)&#xD;1932-6203 (Linking)</isbn><accession-num>22272269</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=22272269</url></related-urls></urls><electronic-resource-num>10.1371/journal.pone.0030010&#xD;PONE-D-11-09364 [pii]</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>ElBeltagy</Author><Year>2010</Year><RecNum>2349</RecNum><record><rec-number>2349</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2349</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>ElBeltagy, M.</author><author>Mustafa, S.</author><author>Umka, J.</author><author>Lyons, L.</author><author>Salman, A.</author><author>Chur-yoe, G. T.</author><author>Bhalla, N.</author><author>Bennett, G.</author><author>Wigmore, P. M.</author></authors></contributors><auth-address>Department of Anatomy, Menoufiya University, Egypt. mbxme1@nottingham.ac.uk</auth-address><titles><title>Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil</title><secondary-title>Behav Brain Res</secondary-title><alt-title>Behaviour Brain Research</alt-title></titles><periodical><full-title>Behav Brain Res</full-title><abbr-1>Behavioural brain research</abbr-1></periodical><pages>112-7</pages><volume>208</volume><number>1</number><edition>2009/11/17</edition><keywords><keyword>Analysis of Variance</keyword><keyword>Animals</keyword><keyword>Cell Proliferation/drug effects</keyword><keyword>Disease Models, Animal</keyword><keyword>Exploratory Behavior/drug effects</keyword><keyword>*Fluorouracil</keyword><keyword>Fluoxetine/*therapeutic use</keyword><keyword>Freezing Reaction, Cataleptic/drug effects</keyword><keyword>Hippocampus/metabolism/pathology</keyword><keyword>Ki-67 Antigen/metabolism</keyword><keyword>Male</keyword><keyword>Memory Disorders/*chemically induced/*drug therapy/pathology</keyword><keyword>Neuropsychological Tests</keyword><keyword>Rats</keyword><keyword>Serotonin Uptake Inhibitors/*therapeutic use</keyword></keywords><dates><year>2010</year><pub-dates><date>Mar 17</date></pub-dates></dates><isbn>1872-7549 (Electronic)&#xD;0166-4328 (Linking)</isbn><accession-num>19914299</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=19914299</url></related-urls></urls><electronic-resource-num>S0166-4328(09)00682-2 [pii]&#xD;10.1016/j.bbr.2009.11.017</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Lyons</Author><Year>2011</Year><RecNum>2350</RecNum><record><rec-number>2350</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2350</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lyons, L.</author><author>ElBeltagy, M.</author><author>Umka, J.</author><author>Markwick, R.</author><author>Startin, C.</author><author>Bennett, G.</author><author>Wigmore, P.</author></authors></contributors><auth-address>School of Biomedical Sciences, University of Nottingham, Queen&apos;s Medical Centre, Nottingham, UK. mbxll@nottingham.ac.uk</auth-address><titles><title>Fluoxetine reverses the memory impairment and reduction in proliferation and survival of hippocampal cells caused by methotrexate chemotherapy</title><secondary-title>Psychopharmacology (Berl)</secondary-title></titles><periodical><full-title>Psychopharmacology (Berl)</full-title><abbr-1>Psychopharmacology</abbr-1></periodical><pages>105-15</pages><volume>215</volume><number>1</number><edition>2010/12/25</edition><keywords><keyword>Administration, Oral</keyword><keyword>Animals</keyword><keyword>Antimetabolites, Antineoplastic/administration &amp; dosage/*adverse effects</keyword><keyword>Behavior, Animal/drug effects</keyword><keyword>Cell Proliferation/*drug effects</keyword><keyword>Cell Survival/drug effects</keyword><keyword>Fluoxetine/administration &amp; dosage/pharmacology/*therapeutic use</keyword><keyword>Hippocampus/*drug effects/pathology</keyword><keyword>Injections, Intravenous</keyword><keyword>Male</keyword><keyword>Memory Disorders/chemically induced/physiopathology/*prevention &amp; control</keyword><keyword>Memory, Short-Term/drug effects</keyword><keyword>Methotrexate/administration &amp; dosage/*adverse effects</keyword><keyword>Neuroprotective Agents/administration &amp; dosage/pharmacology/*therapeutic use</keyword><keyword>Rats</keyword><keyword>Rats, Inbred Strains</keyword></keywords><dates><year>2011</year><pub-dates><date>May</date></pub-dates></dates><isbn>1432-2072 (Electronic)&#xD;0033-3158 (Linking)</isbn><accession-num>21181126</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=21181126</url></related-urls></urls><electronic-resource-num>10.1007/s00213-010-2122-2</electronic-resource-num><language>eng</language></record></Cite></EndNote>�D<EndNote><Cite><Author>Lyons</Author><Year>2012</Year><RecNum>2327</RecNum><DisplayText>[73, 77, 78]</DisplayText><record><rec-number>2327</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2327</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lyons, L.</author><author>ElBeltagy, M.</author><author>Bennett, G.</author><author>Wigmore, P.</author></authors></contributors><auth-address>School of Biomedical Sciences, University of Nottingham, Nottingham, United Kingdom.</auth-address><titles><title>Fluoxetine counteracts the cognitive and cellular effects of 5-fluorouracil in the rat hippocampus by a mechanism of prevention rather than recovery</title><secondary-title>PLoS One</secondary-title></titles><periodical><full-title>PLoS One</full-title></periodical><pages>e30010</pages><volume>7</volume><number>1</number><edition>2012/01/25</edition><dates><year>2012</year></dates><isbn>1932-6203 (Electronic)&#xD;1932-6203 (Linking)</isbn><accession-num>22272269</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=22272269</url></related-urls></urls><electronic-resource-num>10.1371/journal.pone.0030010&#xD;PONE-D-11-09364 [pii]</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>ElBeltagy</Author><Year>2010</Year><RecNum>2349</RecNum><record><rec-number>2349</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2349</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>ElBeltagy, M.</author><author>Mustafa, S.</author><author>Umka, J.</author><author>Lyons, L.</author><author>Salman, A.</author><author>Chur-yoe, G. T.</author><author>Bhalla, N.</author><author>Bennett, G.</author><author>Wigmore, P. M.</author></authors></contributors><auth-address>Department of Anatomy, Menoufiya University, Egypt. mbxme1@nottingham.ac.uk</auth-address><titles><title>Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil</title><secondary-title>Behav Brain Res</secondary-title><alt-title>Behaviour Brain Research</alt-title></titles><periodical><full-title>Behav Brain Res</full-title><abbr-1>Behavioural brain research</abbr-1></periodical><pages>112-7</pages><volume>208</volume><number>1</number><edition>2009/11/17</edition><keywords><keyword>Analysis of Variance</keyword><keyword>Animals</keyword><keyword>Cell Proliferation/drug effects</keyword><keyword>Disease Models, Animal</keyword><keyword>Exploratory Behavior/drug effects</keyword><keyword>*Fluorouracil</keyword><keyword>Fluoxetine/*therapeutic use</keyword><keyword>Freezing Reaction, Cataleptic/drug effects</keyword><keyword>Hippocampus/metabolism/pathology</keyword><keyword>Ki-67 Antigen/metabolism</keyword><keyword>Male</keyword><keyword>Memory Disorders/*chemically induced/*drug therapy/pathology</keyword><keyword>Neuropsychological Tests</keyword><keyword>Rats</keyword><keyword>Serotonin Uptake Inhibitors/*therapeutic use</keyword></keywords><dates><year>2010</year><pub-dates><date>Mar 17</date></pub-dates></dates><isbn>1872-7549 (Electronic)&#xD;0166-4328 (Linking)</isbn><accession-num>19914299</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=19914299</url></related-urls></urls><electronic-resource-num>S0166-4328(09)00682-2 [pii]&#xD;10.1016/j.bbr.2009.11.017</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Lyons</Author><Year>2011</Year><RecNum>2350</RecNum><record><rec-number>2350</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2350</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lyons, L.</author><author>ElBeltagy, M.</author><author>Umka, J.</author><author>Markwick, R.</author><author>Startin, C.</author><author>Bennett, G.</author><author>Wigmore, P.</author></authors></contributors><auth-address>School of Biomedical Sciences, University of Nottingham, Queen&apos;s Medical Centre, Nottingham, UK. mbxll@nottingham.ac.uk</auth-address><titles><title>Fluoxetine reverses the memory impairment and reduction in proliferation and survival of hippocampal cells caused by methotrexate chemotherapy</title><secondary-title>Psychopharmacology (Berl)</secondary-title></titles><periodical><full-title>Psychopharmacology (Berl)</full-title><abbr-1>Psychopharmacology</abbr-1></periodical><pages>105-15</pages><volume>215</volume><number>1</number><edition>2010/12/25</edition><keywords><keyword>Administration, Oral</keyword><keyword>Animals</keyword><keyword>Antimetabolites, Antineoplastic/administration &amp; dosage/*adverse effects</keyword><keyword>Behavior, Animal/drug effects</keyword><keyword>Cell Proliferation/*drug effects</keyword><keyword>Cell Survival/drug effects</keyword><keyword>Fluoxetine/administration &amp; dosage/pharmacology/*therapeutic use</keyword><keyword>Hippocampus/*drug effects/pathology</keyword><keyword>Injections, Intravenous</keyword><keyword>Male</keyword><keyword>Memory Disorders/chemically induced/physiopathology/*prevention &amp; control</keyword><keyword>Memory, Short-Term/drug effects</keyword><keyword>Methotrexate/administration &amp; dosage/*adverse effects</keyword><keyword>Neuroprotective Agents/administration &amp; dosage/pharmacology/*therapeutic use</keyword><keyword>Rats</keyword><keyword>Rats, Inbred Strains</keyword></keywords><dates><year>2011</year><pub-dates><date>May</date></pub-dates></dates><isbn>1432-2072 (Electronic)&#xD;0033-3158 (Linking)</isbn><accession-num>21181126</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=21181126</url></related-urls></urls><electronic-resource-num>10.1007/s00213-010-2122-2</electronic-resource-num><language>eng</language></record></Cite></EndNote>�D<EndNote><Cite><Author>Marcussen</Author><Year>2008</Year><RecNum>2342</RecNum><DisplayText>[74, 75]</DisplayText><record><rec-number>2342</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2342</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Marcussen, A. B.</author><author>Flagstad, P.</author><author>Kristjansen, P. E.</author><author>Johansen, F. F.</author><author>Englund, U.</author></authors></contributors><auth-address>Department of Pharmacology Target Research, H. Lundbeck A/S, Valby, Denmark.</auth-address><titles><title>Increase in neurogenesis and behavioural benefit after chronic fluoxetine treatment in Wistar rats</title><secondary-title>Acta Neurol Scand</secondary-title></titles><periodical><full-title>Acta Neurol Scand</full-title></periodical><pages>94-100</pages><volume>117</volume><number>2</number><edition>2008/01/11</edition><keywords><keyword>Animals</keyword><keyword>Behavior, Animal/*drug effects</keyword><keyword>Bromodeoxyuridine/metabolism</keyword><keyword>Cell Count</keyword><keyword>Cell Proliferation/*drug effects</keyword><keyword>Dentate Gyrus/cytology</keyword><keyword>Drug Administration Schedule</keyword><keyword>Feeding Behavior/drug effects</keyword><keyword>Fluoxetine/*administration &amp; dosage</keyword><keyword>Ki-67 Antigen/metabolism</keyword><keyword>Male</keyword><keyword>Microtubule-Associated Proteins/metabolism</keyword><keyword>Neurons/*drug effects</keyword><keyword>Neuropeptides/metabolism</keyword><keyword>Rats</keyword><keyword>Rats, Wistar</keyword><keyword>Reaction Time/drug effects</keyword><keyword>Serotonin Uptake Inhibitors/*administration &amp; dosage</keyword></keywords><dates><year>2008</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1600-0404 (Electronic)&#xD;0001-6314 (Linking)</isbn><accession-num>18184344</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=18184344</url></related-urls></urls><electronic-resource-num>ANE910 [pii]&#xD;10.1111/j.1600-0404.2007.00910.x</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Zhang</Author><Year>2012</Year><RecNum>2802</RecNum><record><rec-number>2802</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2802</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Zhang, F.</author><author>Zhou, H.</author><author>Wilson, B. C.</author><author>Shi, J. S.</author><author>Hong, J. S.</author><author>Gao, H. M.</author></authors></contributors><auth-address>Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.</auth-address><titles><title>Fluoxetine protects neurons against microglial activation-mediated neurotoxicity</title><secondary-title>Parkinsonism Relat Disord</secondary-title></titles><periodical><full-title>Parkinsonism Relat Disord</full-title></periodical><pages>S213-7</pages><volume>18 Suppl 1</volume><edition>2011/12/23</edition><keywords><keyword>Animals</keyword><keyword>Cells, Cultured</keyword><keyword>Female</keyword><keyword>Fluoxetine/pharmacology/*therapeutic use</keyword><keyword>Microglia/*drug effects/*metabolism/pathology</keyword><keyword>NF-kappa B/antagonists &amp; inhibitors/metabolism</keyword><keyword>Neurons/*drug effects/metabolism/pathology</keyword><keyword>Neuroprotective Agents/pharmacology/*therapeutic use</keyword><keyword>Neurotoxicity Syndromes/metabolism/prevention &amp; control</keyword><keyword>Parkinson Disease/metabolism/*prevention &amp; control</keyword><keyword>Pregnancy</keyword><keyword>Rats</keyword><keyword>Rats, Inbred F344</keyword><keyword>Reactive Oxygen Species/metabolism</keyword></keywords><dates><year>2012</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>1873-5126 (Electronic)&#xD;1353-8020 (Linking)</isbn><accession-num>22166439</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=22166439</url></related-urls></urls><electronic-resource-num>S1353-8020(11)70066-9 [pii]&#xD;10.1016/S1353-8020(11)70066-9</electronic-resource-num><language>eng</language></record></Cite></EndNote>�D<EndNote><Cite><Author>Marcussen</Author><Year>2008</Year><RecNum>2342</RecNum><DisplayText>[74, 75]</DisplayText><record><rec-number>2342</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2342</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Marcussen, A. B.</author><author>Flagstad, P.</author><author>Kristjansen, P. E.</author><author>Johansen, F. F.</author><author>Englund, U.</author></authors></contributors><auth-address>Department of Pharmacology Target Research, H. Lundbeck A/S, Valby, Denmark.</auth-address><titles><title>Increase in neurogenesis and behavioural benefit after chronic fluoxetine treatment in Wistar rats</title><secondary-title>Acta Neurol Scand</secondary-title></titles><periodical><full-title>Acta Neurol Scand</full-title></periodical><pages>94-100</pages><volume>117</volume><number>2</number><edition>2008/01/11</edition><keywords><keyword>Animals</keyword><keyword>Behavior, Animal/*drug effects</keyword><keyword>Bromodeoxyuridine/metabolism</keyword><keyword>Cell Count</keyword><keyword>Cell Proliferation/*drug effects</keyword><keyword>Dentate Gyrus/cytology</keyword><keyword>Drug Administration Schedule</keyword><keyword>Feeding Behavior/drug effects</keyword><keyword>Fluoxetine/*administration &amp; dosage</keyword><keyword>Ki-67 Antigen/metabolism</keyword><keyword>Male</keyword><keyword>Microtubule-Associated Proteins/metabolism</keyword><keyword>Neurons/*drug effects</keyword><keyword>Neuropeptides/metabolism</keyword><keyword>Rats</keyword><keyword>Rats, Wistar</keyword><keyword>Reaction Time/drug effects</keyword><keyword>Serotonin Uptake Inhibitors/*administration &amp; dosage</keyword></keywords><dates><year>2008</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1600-0404 (Electronic)&#xD;0001-6314 (Linking)</isbn><accession-num>18184344</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=18184344</url></related-urls></urls><electronic-resource-num>ANE910 [pii]&#xD;10.1111/j.1600-0404.2007.00910.x</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Zhang</Author><Year>2012</Year><RecNum>2802</RecNum><record><rec-number>2802</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2802</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Zhang, F.</author><author>Zhou, H.</author><author>Wilson, B. C.</author><author>Shi, J. S.</author><author>Hong, J. S.</author><author>Gao, H. M.</author></authors></contributors><auth-address>Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.</auth-address><titles><title>Fluoxetine protects neurons against microglial activation-mediated neurotoxicity</title><secondary-title>Parkinsonism Relat Disord</secondary-title></titles><periodical><full-title>Parkinsonism Relat Disord</full-title></periodical><pages>S213-7</pages><volume>18 Suppl 1</volume><edition>2011/12/23</edition><keywords><keyword>Animals</keyword><keyword>Cells, Cultured</keyword><keyword>Female</keyword><keyword>Fluoxetine/pharmacology/*therapeutic use</keyword><keyword>Microglia/*drug effects/*metabolism/pathology</keyword><keyword>NF-kappa B/antagonists &amp; inhibitors/metabolism</keyword><keyword>Neurons/*drug effects/metabolism/pathology</keyword><keyword>Neuroprotective Agents/pharmacology/*therapeutic use</keyword><keyword>Neurotoxicity Syndromes/metabolism/prevention &amp; 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dosage/*pharmacology</keyword><keyword>Gene Expression Regulation, Neoplastic</keyword><keyword>Humans</keyword><keyword>MCF-7 Cells</keyword><keyword>Proto-Oncogene Proteins c-bcl-2/genetics/metabolism</keyword><keyword>Serotonin Uptake Inhibitors/administration &amp; dosage/*pharmacology</keyword><keyword>Tumor Suppressor Protein p53/genetics/metabolism</keyword></keywords><dates><year>2012</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>1423-0380 (Electronic)&#xD;1010-4283 (Linking)</isbn><accession-num>22549660</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=22549660</url></related-urls></urls><electronic-resource-num>10.1007/s13277-012-0377-4</electronic-resource-num><language>eng</language></record></Cite></EndNote>	D<EndNote><Cite ExcludeYear="1"><Author>Zhou</Author><Year>2012</Year><RecNum>2801</RecNum><DisplayText>[79]</DisplayText><record><rec-number>2801</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2801</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Zhou, T.</author><author>Duan, J.</author><author>Wang, Y.</author><author>Chen, X.</author><author>Zhou, G.</author><author>Wang, R.</author><author>Fu, L.</author><author>Xu, F.</author></authors></contributors><auth-address>Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.</auth-address><titles><title>Fluoxetine synergys with anticancer drugs to overcome multidrug resistance in breast cancer cells</title><secondary-title>Tumour Biol</secondary-title></titles><periodical><full-title>Tumour Biol</full-title></periodical><pages>1299-306</pages><volume>33</volume><number>5</number><edition>2012/05/03</edition><keywords><keyword>Antineoplastic Combined Chemotherapy Protocols/*pharmacology</keyword><keyword>Apoptosis/drug effects</keyword><keyword>Breast Neoplasms/drug therapy/genetics/*metabolism</keyword><keyword>Cell Proliferation/drug effects</keyword><keyword>Drug Resistance, Multiple</keyword><keyword>*Drug Resistance, Neoplasm/genetics</keyword><keyword>Drug Synergism</keyword><keyword>Female</keyword><keyword>Fluoxetine/administration &amp; dosage/*pharmacology</keyword><keyword>Gene Expression Regulation, Neoplastic</keyword><keyword>Humans</keyword><keyword>MCF-7 Cells</keyword><keyword>Proto-Oncogene Proteins c-bcl-2/genetics/metabolism</keyword><keyword>Serotonin Uptake Inhibitors/administration &amp; dosage/*pharmacology</keyword><keyword>Tumor Suppressor Protein p53/genetics/metabolism</keyword></keywords><dates><year>2012</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>1423-0380 (Electronic)&#xD;1010-4283 (Linking)</isbn><accession-num>22549660</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=22549660</url></related-urls></urls><electronic-resource-num>10.1007/s13277-012-0377-4</electronic-resource-num><language>eng</language></record></Cite></EndNote>	D<EndNote><Cite ExcludeYear="1"><Author>Zhou</Author><Year>2012</Year><RecNum>2801</RecNum><DisplayText>[79]</DisplayText><record><rec-number>2801</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2801</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Zhou, T.</author><author>Duan, J.</author><author>Wang, Y.</author><author>Chen, X.</author><author>Zhou, G.</author><author>Wang, R.</author><author>Fu, L.</author><author>Xu, F.</author></authors></contributors><auth-address>Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.</auth-address><titles><title>Fluoxetine synergys with anticancer drugs to overcome multidrug resistance in breast cancer cells</title><secondary-title>Tumour Biol</secondary-title></titles><periodical><full-title>Tumour Biol</full-title></periodical><pages>1299-306</pages><volume>33</volume><number>5</number><edition>2012/05/03</edition><keywords><keyword>Antineoplastic Combined Chemotherapy Protocols/*pharmacology</keyword><keyword>Apoptosis/drug effects</keyword><keyword>Breast Neoplasms/drug therapy/genetics/*metabolism</keyword><keyword>Cell Proliferation/drug effects</keyword><keyword>Drug Resistance, Multiple</keyword><keyword>*Drug Resistance, Neoplasm/genetics</keyword><keyword>Drug Synergism</keyword><keyword>Female</keyword><keyword>Fluoxetine/administration &amp; dosage/*pharmacology</keyword><keyword>Gene Expression Regulation, Neoplastic</keyword><keyword>Humans</keyword><keyword>MCF-7 Cells</keyword><keyword>Proto-Oncogene Proteins c-bcl-2/genetics/metabolism</keyword><keyword>Serotonin Uptake Inhibitors/administration &amp; dosage/*pharmacology</keyword><keyword>Tumor Suppressor Protein p53/genetics/metabolism</keyword></keywords><dates><year>2012</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>1423-0380 (Electronic)&#xD;1010-4283 (Linking)</isbn><accession-num>22549660</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=22549660</url></related-urls></urls><electronic-resource-num>10.1007/s13277-012-0377-4</electronic-resource-num><language>eng</language></record></Cite></EndNote>�D<EndNote><Cite><Author>Kannen</Author><Year>2011</Year><RecNum>2805</RecNum><DisplayText>[80, 81]</DisplayText><record><rec-number>2805</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2805</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kannen, V.</author><author>Marini, T.</author><author>Turatti, A.</author><author>Carvalho, M. C.</author><author>Brandao, M. L.</author><author>Jabor, V. A.</author><author>Bonato, P. S.</author><author>Ferreira, F. R.</author><author>Zanette, D. L.</author><author>Silva, W. A., Jr.</author><author>Garcia, S. B.</author></authors></contributors><auth-address>Department of Pathology, Medical School of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto 14049-900, Brazil. kannen71@yahoo.com</auth-address><titles><title>Fluoxetine induces preventive and complex effects against colon cancer development in epithelial and stromal areas in rats</title><secondary-title>Toxicol Lett</secondary-title></titles><periodical><full-title>Toxicol Lett</full-title></periodical><pages>134-40</pages><volume>204</volume><number>2-3</number><edition>2011/05/11</edition><keywords><keyword>Animals</keyword><keyword>Cell Proliferation</keyword><keyword>Colon/drug effects/metabolism</keyword><keyword>Colonic Neoplasms/*prevention &amp; control</keyword><keyword>Cyclooxygenase 2/analysis</keyword><keyword>Fluoxetine/*pharmacology</keyword><keyword>Male</keyword><keyword>Precancerous Conditions/prevention &amp; control</keyword><keyword>Rats</keyword><keyword>Rats, Wistar</keyword><keyword>Serotonin/metabolism</keyword><keyword>Serotonin Uptake Inhibitors/*pharmacology</keyword><keyword>Vascular Endothelial Growth Factor A/analysis</keyword></keywords><dates><year>2011</year><pub-dates><date>Jul 28</date></pub-dates></dates><isbn>1879-3169 (Electronic)&#xD;0378-4274 (Linking)</isbn><accession-num>21554931</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=21554931</url></related-urls></urls><electronic-resource-num>S0378-4274(11)00190-1 [pii]&#xD;10.1016/j.toxlet.2011.04.024</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Kannen</Author><Year>2012</Year><RecNum>2806</RecNum><record><rec-number>2806</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2806</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kannen, V.</author><author>Hintzsche, H.</author><author>Zanette, D. 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B.</author></authors></contributors><auth-address>Department of Pathology, Medical School of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto 14049-900, Brazil. kannen71@yahoo.com</auth-address><titles><title>Fluoxetine induces preventive and complex effects against colon cancer development in epithelial and stromal areas in rats</title><secondary-title>Toxicol Lett</secondary-title></titles><periodical><full-title>Toxicol Lett</full-title></periodical><pages>134-40</pages><volume>204</volume><number>2-3</number><edition>2011/05/11</edition><keywords><keyword>Animals</keyword><keyword>Cell Proliferation</keyword><keyword>Colon/drug effects/metabolism</keyword><keyword>Colonic Neoplasms/*prevention &amp; control</keyword><keyword>Cyclooxygenase 2/analysis</keyword><keyword>Fluoxetine/*pharmacology</keyword><keyword>Male</keyword><keyword>Precancerous Conditions/prevention &amp; control</keyword><keyword>Rats</keyword><keyword>Rats, Wistar</keyword><keyword>Serotonin/metabolism</keyword><keyword>Serotonin Uptake Inhibitors/*pharmacology</keyword><keyword>Vascular Endothelial Growth Factor A/analysis</keyword></keywords><dates><year>2011</year><pub-dates><date>Jul 28</date></pub-dates></dates><isbn>1879-3169 (Electronic)&#xD;0378-4274 (Linking)</isbn><accession-num>21554931</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=21554931</url></related-urls></urls><electronic-resource-num>S0378-4274(11)00190-1 [pii]&#xD;10.1016/j.toxlet.2011.04.024</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Kannen</Author><Year>2012</Year><RecNum>2806</RecNum><record><rec-number>2806</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2806</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kannen, V.</author><author>Hintzsche, H.</author><author>Zanette, D. 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F.</author></authors></contributors><auth-address>Institute of Psychiatry, King&apos;s College London, London, UK. petroula.proitsi@kcl.ac.uk</auth-address><titles><title>Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia</title><secondary-title>Neurobiol Aging</secondary-title><alt-title>Neurobiology of aging</alt-title></titles><periodical><full-title>Neurobiol Aging</full-title></periodical><alt-periodical><full-title>Neurobiol Aging</full-title><abbr-1>Neurobiology of aging</abbr-1></alt-periodical><pages>791-803</pages><volume>33</volume><number>4</number><keywords><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Apolipoprotein E4/genetics</keyword><keyword>Behavioral Symptoms/etiology/*genetics</keyword><keyword>Catechol O-Methyltransferase/genetics</keyword><keyword>Chi-Square Distribution</keyword><keyword>Cohort Studies</keyword><keyword>DNA Mutational Analysis</keyword><keyword>*Dementia/complications/genetics/psychology</keyword><keyword>Dopamine/*genetics</keyword><keyword>Dopamine Plasma Membrane Transport Proteins</keyword><keyword>Female</keyword><keyword>Genetic Association Studies</keyword><keyword>Genetic Predisposition to Disease/*genetics</keyword><keyword>Genotype</keyword><keyword>Great Britain</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Minisatellite Repeats/genetics</keyword><keyword>Models, Biological</keyword><keyword>Monoamine Oxidase/genetics</keyword><keyword>Polymorphism, Genetic/*genetics</keyword><keyword>Psychiatric Status Rating Scales</keyword><keyword>Receptors, Dopamine</keyword><keyword>Risk Factors</keyword><keyword>Serotonin/*genetics</keyword><keyword>Serotonin Plasma Membrane Transport Proteins</keyword><keyword>Signal Transduction/*genetics</keyword></keywords><dates><year>2012</year><pub-dates><date>Apr</date></pub-dates></dates><isbn>1558-1497 (Electronic)&#xD;0197-4580 (Linking)</isbn><accession-num>20685009</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/20685009</url></related-urls></urls><electronic-resource-num>10.1016/j.neurobiolaging.2010.06.011</electronic-resource-num></record></Cite></EndNote>Z	D<EndNote><Cite><Author>Murphy</Author><Year>2003</Year><RecNum>2353</RecNum><DisplayText>[88]</DisplayText><record><rec-number>2353</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2353</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Murphy, G. M.</author><author>Kremer, C.</author><author>Rodrigues, H.</author><author>Schatzberg, A. F.</author></authors></contributors><auth-address>Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA.</auth-address><titles><title>The apolipoprotein E epsilon4 allele and antidepressant efficacy in cognitively intact elderly depressed patients</title><secondary-title>Biol Psychiatry</secondary-title></titles><periodical><full-title>Biol Psychiatry</full-title></periodical><pages>665-73</pages><volume>54</volume><number>7</number><edition>2003/09/27</edition><keywords><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>*Alleles</keyword><keyword>Antidepressive Agents/blood/*therapeutic use</keyword><keyword>Apolipoproteins E/genetics/*metabolism</keyword><keyword>Chromatography, High Pressure Liquid</keyword><keyword>Cognition/*drug effects</keyword><keyword>Depression/blood/*drug therapy/genetics/physiopathology</keyword><keyword>Dose-Response Relationship, Drug</keyword><keyword>Double-Blind Method</keyword><keyword>Female</keyword><keyword>Genotype</keyword><keyword>Geriatric Psychiatry</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Mianserin/analogs &amp; derivatives/blood/therapeutic use</keyword><keyword>Neuropsychological Tests</keyword><keyword>Paroxetine/blood/therapeutic use</keyword><keyword>Psychiatric Status Rating Scales</keyword><keyword>Time Factors</keyword><keyword>Treatment Outcome</keyword></keywords><dates><year>2003</year><pub-dates><date>Oct 1</date></pub-dates></dates><isbn>0006-3223 (Print)&#xD;0006-3223 (Linking)</isbn><accession-num>14512205</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=14512205</url></related-urls></urls><electronic-resource-num>S0006322303001744 [pii]</electronic-resource-num><language>eng</language></record></Cite></EndNote>Z	D<EndNote><Cite><Author>Murphy</Author><Year>2003</Year><RecNum>2353</RecNum><DisplayText>[88]</DisplayText><record><rec-number>2353</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2353</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Murphy, G. M.</author><author>Kremer, C.</author><author>Rodrigues, H.</author><author>Schatzberg, A. F.</author></authors></contributors><auth-address>Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA.</auth-address><titles><title>The apolipoprotein E epsilon4 allele and antidepressant efficacy in cognitively intact elderly depressed patients</title><secondary-title>Biol Psychiatry</secondary-title></titles><periodical><full-title>Biol Psychiatry</full-title></periodical><pages>665-73</pages><volume>54</volume><number>7</number><edition>2003/09/27</edition><keywords><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>*Alleles</keyword><keyword>Antidepressive Agents/blood/*therapeutic use</keyword><keyword>Apolipoproteins E/genetics/*metabolism</keyword><keyword>Chromatography, High Pressure Liquid</keyword><keyword>Cognition/*drug effects</keyword><keyword>Depression/blood/*drug therapy/genetics/physiopathology</keyword><keyword>Dose-Response Relationship, Drug</keyword><keyword>Double-Blind Method</keyword><keyword>Female</keyword><keyword>Genotype</keyword><keyword>Geriatric Psychiatry</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Mianserin/analogs &amp; derivatives/blood/therapeutic use</keyword><keyword>Neuropsychological Tests</keyword><keyword>Paroxetine/blood/therapeutic use</keyword><keyword>Psychiatric Status Rating Scales</keyword><keyword>Time Factors</keyword><keyword>Treatment Outcome</keyword></keywords><dates><year>2003</year><pub-dates><date>Oct 1</date></pub-dates></dates><isbn>0006-3223 (Print)&#xD;0006-3223 (Linking)</isbn><accession-num>14512205</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=14512205</url></related-urls></urls><electronic-resource-num>S0006322303001744 [pii]</electronic-resource-num><language>eng</language></record></Cite></EndNote>Z	D<EndNote><Cite><Author>Murphy</Author><Year>2003</Year><RecNum>2353</RecNum><DisplayText>[88]</DisplayText><record><rec-number>2353</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2353</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Murphy, G. M.</author><author>Kremer, C.</author><author>Rodrigues, H.</author><author>Schatzberg, A. F.</author></authors></contributors><auth-address>Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA.</auth-address><titles><title>The apolipoprotein E epsilon4 allele and antidepressant efficacy in cognitively intact elderly depressed patients</title><secondary-title>Biol Psychiatry</secondary-title></titles><periodical><full-title>Biol Psychiatry</full-title></periodical><pages>665-73</pages><volume>54</volume><number>7</number><edition>2003/09/27</edition><keywords><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>*Alleles</keyword><keyword>Antidepressive Agents/blood/*therapeutic use</keyword><keyword>Apolipoproteins E/genetics/*metabolism</keyword><keyword>Chromatography, High Pressure Liquid</keyword><keyword>Cognition/*drug effects</keyword><keyword>Depression/blood/*drug therapy/genetics/physiopathology</keyword><keyword>Dose-Response Relationship, Drug</keyword><keyword>Double-Blind Method</keyword><keyword>Female</keyword><keyword>Genotype</keyword><keyword>Geriatric Psychiatry</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Mianserin/analogs &amp; derivatives/blood/therapeutic use</keyword><keyword>Neuropsychological Tests</keyword><keyword>Paroxetine/blood/therapeutic use</keyword><keyword>Psychiatric Status Rating Scales</keyword><keyword>Time Factors</keyword><keyword>Treatment Outcome</keyword></keywords><dates><year>2003</year><pub-dates><date>Oct 1</date></pub-dates></dates><isbn>0006-3223 (Print)&#xD;0006-3223 (Linking)</isbn><accession-num>14512205</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=14512205</url></related-urls></urls><electronic-resource-num>S0006322303001744 [pii]</electronic-resource-num><language>eng</language></record></Cite></EndNote>Z	D<EndNote><Cite><Author>Murphy</Author><Year>2003</Year><RecNum>2353</RecNum><DisplayText>[88]</DisplayText><record><rec-number>2353</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2353</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Murphy, G. M.</author><author>Kremer, C.</author><author>Rodrigues, H.</author><author>Schatzberg, A. F.</author></authors></contributors><auth-address>Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA.</auth-address><titles><title>The apolipoprotein E epsilon4 allele and antidepressant efficacy in cognitively intact elderly depressed patients</title><secondary-title>Biol Psychiatry</secondary-title></titles><periodical><full-title>Biol Psychiatry</full-title></periodical><pages>665-73</pages><volume>54</volume><number>7</number><edition>2003/09/27</edition><keywords><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>*Alleles</keyword><keyword>Antidepressive Agents/blood/*therapeutic use</keyword><keyword>Apolipoproteins E/genetics/*metabolism</keyword><keyword>Chromatography, High Pressure Liquid</keyword><keyword>Cognition/*drug effects</keyword><keyword>Depression/blood/*drug therapy/genetics/physiopathology</keyword><keyword>Dose-Response Relationship, Drug</keyword><keyword>Double-Blind Method</keyword><keyword>Female</keyword><keyword>Genotype</keyword><keyword>Geriatric Psychiatry</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Mianserin/analogs &amp; derivatives/blood/therapeutic use</keyword><keyword>Neuropsychological Tests</keyword><keyword>Paroxetine/blood/therapeutic use</keyword><keyword>Psychiatric Status Rating Scales</keyword><keyword>Time Factors</keyword><keyword>Treatment Outcome</keyword></keywords><dates><year>2003</year><pub-dates><date>Oct 1</date></pub-dates></dates><isbn>0006-3223 (Print)&#xD;0006-3223 (Linking)</isbn><accession-num>14512205</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=14512205</url></related-urls></urls><electronic-resource-num>S0006322303001744 [pii]</electronic-resource-num><language>eng</language></record></Cite></EndNote>*
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D<EndNote><Cite><Author>Tamayo</Author><Year>2009</Year><RecNum>2351</RecNum><DisplayText>[89]</DisplayText><record><rec-number>2351</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2351</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Tamayo, J. M.</author><author>Sutton, V. K.</author><author>Mattei, M. A.</author><author>Diaz, B.</author><author>Jamal, H. H.</author><author>Vieta, E.</author><author>Zarate, C. A., Jr.</author><author>Fumero, I.</author><author>Tohen, M.</author></authors></contributors><auth-address>CES University, Medellin, Colombia. tamayojm@gmail.com</auth-address><titles><title>Effectiveness and safety of the combination of fluoxetine and olanzapine in outpatients with bipolar depression: an open-label, randomized, flexible-dose study in Puerto Rico</title><secondary-title>J Clin Psychopharmacol</secondary-title></titles><periodical><full-title>J Clin Psychopharmacol</full-title></periodical><pages>358-61</pages><volume>29</volume><number>4</number><edition>2009/07/14</edition><keywords><keyword>Adult</keyword><keyword>Antidepressive Agents/*administration &amp; dosage/adverse effects</keyword><keyword>Benzodiazepines/*administration &amp; dosage/adverse effects</keyword><keyword>Bipolar Disorder/*drug therapy/ethnology/psychology</keyword><keyword>Drug Combinations</keyword><keyword>Female</keyword><keyword>Fluoxetine/*administration &amp; dosage/adverse effects</keyword><keyword>Hispanic Americans</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>*Outpatients</keyword><keyword>Psychiatric Status Rating Scales</keyword><keyword>Puerto Rico</keyword><keyword>Recurrence/prevention &amp; control</keyword><keyword>Remission Induction</keyword><keyword>Serotonin Uptake Inhibitors/*administration &amp; dosage/adverse effects</keyword><keyword>Severity of Illness Index</keyword><keyword>Time Factors</keyword><keyword>Treatment Outcome</keyword></keywords><dates><year>2009</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>1533-712X (Electronic)&#xD;0271-0749 (Linking)</isbn><accession-num>19593175</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=19593175</url></related-urls></urls><electronic-resource-num>10.1097/JCP.0b013e3181ad223f&#xD;00004714-200908000-00009 [pii]</electronic-resource-num><language>eng</language></record></Cite></EndNote>�D<EndNote><Cite><Author>Raeder</Author><Year>2006</Year><RecNum>2352</RecNum><DisplayText>[90]</DisplayText><record><rec-number>2352</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2352</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Raeder, M. 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M.</author></authors></contributors><auth-address>Einar Martens&apos; Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Helse Bergen HF, Norway. maria.rader@uib.no</auth-address><titles><title>Obesity, dyslipidemia, and diabetes with selective serotonin reuptake inhibitors: the Hordaland Health Study</title><secondary-title>J Clin Psychiatry</secondary-title></titles><periodical><full-title>J Clin Psychiatry</full-title><abbr-1>The Journal of clinical psychiatry</abbr-1></periodical><pages>1974-82</pages><volume>67</volume><number>12</number><edition>2006/12/30</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Cross-Sectional Studies</keyword><keyword>Diabetes Mellitus/chemically induced/*epidemiology</keyword><keyword>Dyslipidemias/chemically induced/*epidemiology</keyword><keyword>Female</keyword><keyword>Health Surveys</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Metabolic Syndrome X/chemically induced/epidemiology</keyword><keyword>Middle Aged</keyword><keyword>Norway/epidemiology</keyword><keyword>Obesity/chemically induced/*epidemiology</keyword><keyword>Odds Ratio</keyword><keyword>Prevalence</keyword><keyword>Serotonin Uptake Inhibitors/*adverse effects/therapeutic use</keyword></keywords><dates><year>2006</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>1555-2101 (Electronic)&#xD;0160-6689 (Linking)</isbn><accession-num>17194277</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=17194277</url></related-urls></urls><language>eng</language></record></Cite></EndNote>�D<EndNote><Cite><Author>Raeder</Author><Year>2006</Year><RecNum>2352</RecNum><DisplayText>[90]</DisplayText><record><rec-number>2352</rec-number><foreign-keys><key app="EN" db-id="a2tsdvzeja2dwcep0zs5vwxq5sdpw22taxs2">2352</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Raeder, M. 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