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Bronchioloalveolar carcinoma in a 4 -year old child: A Case report
Derya �zy�r�k1, Sibel Akp1nar Tekg�nd�z2, S�heyla Ocak Y1ld1r1m1, Nalan Aky�rek3, Sema Apayd1n4, Hasibe G�k�e �1nar5, G�rses ^ahin2, Ceyhun Bozkurt2 
1Health of Ministry, Sanl1urfa Children's Hospital, Division of Pediatric Oncology, Sanl1urfa, Turkey
2Dr. Sami Ulus Research and Training Hospital of Women's and Children's Health and Diseases, Department of Pediatric Oncology, Ankara, Turkey
3Gazi University, Faculty of Medicine,  Department of Pathology, Ankara, Turkey 
4Dr. Sami Ulus Research and Training Hospital of Women's and Children's Health and Diseases, Department of Pathology, Ankara, Turkey
5Dr. Sami Ulus Research and Training Hospital of Women's and Children's Health and Diseases, Department of Radiology, Ankara, Turkey


*Corresponding author: Derya �zy�r�k, MD
Tel: 090-312-5969600, Email: HYPERLINK "mailto:dozyoruk@yahoo.com"dozyoruk@yahoo.com
Text word count: 777
Abstract word count: 44
Brief running title: Bronchioloalveolar carcinoma 

Key words: Adenocarcinoma; rare tumor;  bronchioloalveolar adenocarcinoma
Tables: 0
Figures: 1
Abstract
The primary pulmonary tumors are very rare in childhood. The most frequent form of lung cancer are carcinoid, plasma cell granuloma, pulmonary blastoma, or mucoepidermoid carcinoma. We present a non-mucinous type bronchioloalveolar carcinoma which is a rare form of primary pulmonary tumor in childhood.

Introduction
Primary pulmonary cancer is extremely rare in childhood. It comprises 0,2% of all childhood malignancies. The most frequent forms are carcinoid, plasma cell granuloma, pulmonary blastoma, or mucoepidermoid carcinoma ADDIN EN.CITE  ADDIN EN.CITE.DATA  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_1" \o "Cohen, 1992 #2146" 1], ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_2" \o "Hartman, 1983 #2148" 2], ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_3" \o "Dishop, 2008 #2183" 3]. Bronchioloalveolar carcinoma (BAC), a variant of adenocarcinoma, represents a very small fraction of these malignancies ADDIN EN.CITE <EndNote><Cite><Author>Ohye</Author><Year>1998</Year><RecNum>4169</RecNum><DisplayText>[4]</DisplayText><record><rec-number>4169</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">4169</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ohye, R. G.</author><author>Cohen, D. M.</author><author>Caldwell, S.</author><author>Qualman, S. J.</author></authors></contributors><auth-address>Department of Thoracic Surgery, Children&apos;s Hospital, Ohio State University, Columbus 43205, USA.</auth-address><titles><title>Pediatric bronchioloalveolar carcinoma: a favorable pediatric malignancy?</title><secondary-title>J Pediatr Surg</secondary-title><alt-title>Journal of pediatric surgery</alt-title></titles><periodical><full-title>J Pediatr Surg</full-title></periodical><pages>730-2</pages><volume>33</volume><number>5</number><edition>1998/06/02</edition><keywords><keyword>Adenocarcinoma, Bronchiolo-Alveolar/*pathology/*surgery</keyword><keyword>Adolescent</keyword><keyword>Child</keyword><keyword>Disease-Free Survival</keyword><keyword>Female</keyword><keyword>Follow-Up Studies</keyword><keyword>Humans</keyword><keyword>Lung Neoplasms/*pathology/*surgery</keyword><keyword>Male</keyword><keyword>Pneumonectomy</keyword></keywords><dates><year>1998</year><pub-dates><date>May</date></pub-dates></dates><isbn>0022-3468 (Print)&#xD;0022-3468 (Linking)</isbn><accession-num>9607481</accession-num><work-type>Case Reports</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/9607481</url></related-urls></urls><language>eng</language></record></Cite></EndNote>[ HYPERLINK \l "_ENREF_4" \o "Ohye, 1998 #4169" 4]. Here, we present a non-mucinous type, BAC in a 4-year old child.
Case:
A 4- year old male was presented with diagnosis of pneumonia unresponsive to sistemic antibiotherapy.  His thorax computed tomography (CT) revealed multiple paranchimal nodules in different sizes throughout the lobes bilaterally ( the larger nodul at the right upper lob in 4 cm diameter with fine calcifications) together with cavitary lesions, athelectasis and pleural thickening as well as perihilar lymphadenopathy (Figure 1 A). The incisional biopsy revealed non-mucinous bronchioloalveolar carcinoma (BAC), formed of papillary clusters and comprised of lepidic growth (single cell row) atypical cells with hyperchromatic pleomorphic nuclei, and eosinophilic cytoplasm lining by alveolar wall (Figure 1 B). Immunohistchemical staining demonstrated positivity for cytokeratin 7 (CK 7) and transcription factor E-3 (TFE-3) in neoplastic cells with negative staining for thyroid transcription factor-1 (TTF-1), napsin A, CK 20, COX-2, PAX-2, PAX-8, thyroglobulin, ITF-1 and WT-1 (Figure 1 C). On his past history, he has been diagnosed with cerebral palsy and on medication with four antiepileptic drugs. Also, he has a history of recurrent pulmonary infections. His mother was diagnosed with breast cancer and heavy smoker. Complete metastatic work-up failed to show any primary site other than in the lungs. The chemotherapy including gemcitabine (1250 mg/m2) on day 1 and 8 and carboplatine (450 mg/m2) on day 1 was started. During chemotherapy cycles, the patient was suffered recurrent aspiration pneumonia and convulsions. After 2 cycles, thorax CT has not shown any regression of masses sizes. Chemotherapy was switched to taxole and carboplatine treatment. After 6 cycles, the patient died because of progressive disease. 
Discussion
Unlike adults, BAC is seen very rarely in childhood. In contrast to other forms of primary lung carcinoma, smoking and environmental exposures do not seem to play a role of its  pathogenesis.  It has been noted that BAC may be found in areas of old scar formation including healed tuberculous lesions, old abscess cavities, or old pulmonary infarcts in several reports  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_4" \o "Ohye, 1998 #4169" 4;  HYPERLINK \l "_ENREF_5" \o "Kayton,  #2075" 5;  HYPERLINK \l "_ENREF_6" \o "Park, 2008 #2532" 6]. Although, there is a considerable debate about the relationship between epilepsy and cancer, it has been reported the incidence of cancer was increased in people with epilepsy and antiepileptic drugs promote cancer  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_7" \o "Kaae, 2014 #4170" 7]. Our case has been using four antiepileptic medications because of cerebral palsy and epilepsy. The antiepileptic drugs which are sometimes causing myelosupression and recurrent pulmonary infections may be facilitated cancer formation.
So far, pediatric bronchioloalveolar carcinoma has been reported very rarely without arised from congenital pulmonary airway malformation or as a secondary malignancy  ADDIN EN.CITE <EndNote><Cite><Author>Dosanjh</Author><Year>1992</Year><RecNum>4155</RecNum><DisplayText>[8]</DisplayText><record><rec-number>4155</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">4155</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Dosanjh, A.</author></authors></contributors><auth-address>Division of Pulmonary Medicine, Children&apos;s Hospital, Boston, Massachusetts.</auth-address><titles><title>Bronchioalveolar carcinoma in a 15-year-old girl</title><secondary-title>Clin Pediatr (Phila)</secondary-title><alt-title>Clinical pediatrics</alt-title></titles><periodical><full-title>Clin Pediatr (Phila)</full-title></periodical><pages>253-4</pages><volume>31</volume><number>4</number><edition>1992/04/01</edition><keywords><keyword>Adenocarcinoma, Bronchiolo-Alveolar/*diagnosis</keyword><keyword>Adolescent</keyword><keyword>Biopsy</keyword><keyword>Bronchoscopy</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Lung Neoplasms/*diagnosis</keyword><keyword>Tomography, X-Ray Computed</keyword></keywords><dates><year>1992</year><pub-dates><date>Apr</date></pub-dates></dates><isbn>0009-9228 (Print)&#xD;0009-9228 (Linking)</isbn><accession-num>1314155</accession-num><work-type>Case Reports&#xD;Letter</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/1314155</url></related-urls></urls><language>eng</language></record></Cite></EndNote>[ HYPERLINK \l "_ENREF_8" \o "Dosanjh, 1992 #4155" 8],  ADDIN EN.CITE <EndNote><Cite><Author>Kartasheva</Author><Year>1986</Year><RecNum>2070</RecNum><DisplayText>[9]</DisplayText><record><rec-number>2070</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">2070</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kartasheva, V. I.</author><author>Zairat&apos;iants, O. V.</author><author>Komarkova, N. N.</author><author>El&apos;iashevich, VIa</author></authors></contributors><titles><title>[Bronchiolo-alveolar lung cancer in a 10-year-old child with paraneoplastic systemic lupus erythematosus]</title><secondary-title>Pediatriia</secondary-title></titles><periodical><full-title>Pediatriia</full-title></periodical><pages>64-5</pages><number>6</number><edition>1986/06/01</edition><keywords><keyword>Adenocarcinoma, Bronchiolo-Alveolar/complications/*diagnosis</keyword><keyword>Child</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Lung Neoplasms/complications/*diagnosis</keyword><keyword>Lupus Erythematosus, Systemic/complications/*diagnosis</keyword><keyword>Paraneoplastic Syndromes/*diagnosis</keyword></keywords><dates><year>1986</year><pub-dates><date>Jun</date></pub-dates></dates><orig-pub>Bronkhioloal&apos;veoliarnyi rak legkogo u rebenka 10 let s paraneoplasticheskoi sistemnoi krasnoi bolchankoi.</orig-pub><isbn>0031-403X (Print)&#xD;0031-403X (Linking)</isbn><accession-num>3018662</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=3018662</url></related-urls></urls><language>rus</language></record></Cite></EndNote>[ HYPERLINK \l "_ENREF_9" \o "Kartasheva, 1986 #2070" 9], ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_10" \o "Ramos, 2007 #4168" 10]. Ohye et al described two cases BAC (ages 6 and 15 years) and noted that it is more indolent course than adult type, because they remained asymptomatic for years after a completion lobectomy.  Surgery has been accepted as the primary treatment for BAC, because neither chemotherapy nor radiation therapy has been proven effective ADDIN EN.CITE <EndNote><Cite><Author>Ohye</Author><Year>1998</Year><RecNum>4169</RecNum><DisplayText>[4]</DisplayText><record><rec-number>4169</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">4169</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ohye, R. G.</author><author>Cohen, D. M.</author><author>Caldwell, S.</author><author>Qualman, S. J.</author></authors></contributors><auth-address>Department of Thoracic Surgery, Children&apos;s Hospital, Ohio State University, Columbus 43205, USA.</auth-address><titles><title>Pediatric bronchioloalveolar carcinoma: a favorable pediatric malignancy?</title><secondary-title>J Pediatr Surg</secondary-title><alt-title>Journal of pediatric surgery</alt-title></titles><periodical><full-title>J Pediatr Surg</full-title></periodical><pages>730-2</pages><volume>33</volume><number>5</number><edition>1998/06/02</edition><keywords><keyword>Adenocarcinoma, Bronchiolo-Alveolar/*pathology/*surgery</keyword><keyword>Adolescent</keyword><keyword>Child</keyword><keyword>Disease-Free Survival</keyword><keyword>Female</keyword><keyword>Follow-Up Studies</keyword><keyword>Humans</keyword><keyword>Lung Neoplasms/*pathology/*surgery</keyword><keyword>Male</keyword><keyword>Pneumonectomy</keyword></keywords><dates><year>1998</year><pub-dates><date>May</date></pub-dates></dates><isbn>0022-3468 (Print)&#xD;0022-3468 (Linking)</isbn><accession-num>9607481</accession-num><work-type>Case Reports</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/9607481</url></related-urls></urls><language>eng</language></record></Cite></EndNote>[ HYPERLINK \l "_ENREF_4" \o "Ohye, 1998 #4169" 4]. Our case was inoperable, due to  mult1ple lesions in both lungs and unresponsive to chemotherapy.
 	The most common clinical findings include cough, dyspnea, chest pain, hemoptysis, and weight loss. The chest roentgenogram varies widely including a solitary nodule or mass, diffuse nodularity, and local or diffuse pulmonary consolidation. Also, pleural effusions, pleural retraction with a �tail sign,� or hilar metastases could be other findings ADDIN EN.CITE <EndNote><Cite><Author>Hill</Author><Year>1984</Year><RecNum>4261</RecNum><DisplayText>[11]</DisplayText><record><rec-number>4261</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">4261</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hill, C. A.</author></authors></contributors><titles><title>Bronchioloalveolar carcinoma: a review</title><secondary-title>Radiology</secondary-title><alt-title>Radiology</alt-title></titles><periodical><full-title>Radiology</full-title></periodical><alt-periodical><full-title>Radiology</full-title></alt-periodical><pages>15-20</pages><volume>150</volume><number>1</number><edition>1984/01/01</edition><keywords><keyword>Adenocarcinoma, Bronchiolo-Alveolar/*radiography</keyword><keyword>Bone Neoplasms/radiography/secondary</keyword><keyword>Humans</keyword><keyword>Lung Neoplasms/*radiography</keyword><keyword>Retrospective Studies</keyword><keyword>Time Factors</keyword></keywords><dates><year>1984</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>0033-8419 (Print)&#xD;0033-8419 (Linking)</isbn><accession-num>6316417</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/6316417</url></related-urls></urls><electronic-resource-num>10.1148/radiology.150.1.6316417</electronic-resource-num><language>eng</language></record></Cite></EndNote>[ HYPERLINK \l "_ENREF_11" \o "Hill, 1984 #4261" 11].  Similarly, our case�s radiologycal analysis revealed multiple paranchimal nodules in different sizes throughout the lobes bilaterally together with cavitary lesions, athelectasis and pleural thickening as well as perihilar lymphadenopathy.
The primary pulmonary tumors are infrequent in childhood and distinguishing primary pulmonary adenocarcinoma from adenocarcinoma metastatic to the lung is a common diagnostic problem especially in BACs, which might manifest as multiple nodules indistinguishable radiologically from metastases. Immunohistochemical analysis is a useful diagnostic utility for determining the site of origin in such cases  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_12" \o "Chhieng, 2001 #4237" 12] . We differentiated from  renal cell carcinoma because of PAX2, PAX8, WT-1 stains were negative and CK 7 was positive in present case. The metastases originated from gastrointestinal tract were excluded because of CK 20 and COX-2 negativity. In addition, because of negative immunreactivity of TTF-1 and thyroglobulin, primary thyroid neoplasm were rule out. Also complete metastatic work-up failed to show any primary site other than in the lungs, clinically and radiographically. 
In conclusion, therefore, the prognosis of inoperable BAC with advanced stage remains poor in childhood, a high index of suspicion in pediatric patients with recurrent or persistent pulmonary symptoms is required for diagnosing at an early stage to improve survival of pediatric BAC.

References
 ADDIN EN.REFLIST [1]M.C. Cohen, R.O. Kaschula, Primary pulmonary tumors in childhood: a review of 31 years' experience and the literature. Pediatr Pulmonol 14 (1992) 222-232.
[2]G.E. Hartman, S.J. Shochat, Primary pulmonary neoplasms of childhood: a review. Ann Thorac Surg 36 (1983) 108-119.
[3]M.K. Dishop, S. Kuruvilla, Primary and metastatic lung tumors in the pediatric population: a review and 25-year experience at a large children's hospital. Arch Pathol Lab Med 132 (2008) 1079-1103.
[4]R.G. Ohye, D.M. Cohen, S. Caldwell, S.J. Qualman, Pediatric bronchioloalveolar carcinoma: a favorable pediatric malignancy? J Pediatr Surg 33 (1998) 730-732.
[5]M.L. Kayton, M. He, M.F. Zakowski, A.L. Moreira, C. Lau, A.J. Chou, M. Merchant, P.R. Merola, L.H. Wexler, M.P. La Quaglia, W.D. Travis, M. Ladanyi, Primary lung adenocarcinomas in children and adolescents treated for pediatric malignancies. J Thorac Oncol 5 1764-1771.
[6]J.A. Park, H.J. Park, J.S. Lee, J.O. Ha, G.K. Lee, B.K. Park, T.T. Ghim, Adenocarcinoma of lung in never smoked children. Lung Cancer 61 (2008) 266-269.
[7]J. Kaae, L. Carstensen, J. Wohlfahrt, M. Melbye, H. Allison Boyd, Epilepsy, anti-epileptic medication use and risk of cancer. Int J Cancer 134 (2014) 932-938.
[8]A. Dosanjh, Bronchioalveolar carcinoma in a 15-year-old girl. Clin Pediatr (Phila) 31 (1992) 253-254.
[9]V.I. Kartasheva, O.V. Zairat'iants, N.N. Komarkova, V. El'iashevich, [Bronchiolo-alveolar lung cancer in a 10-year-old child with paraneoplastic systemic lupus erythematosus]. Pediatriia (1986) 64-65.
[10]S.G. Ramos, G.H. Barbosa, F.R. Tavora, J. Jeudy, L.A. Torres, L.G. Tone, C.S. Trad, Bronchioloalveolar carcinoma arising in a congenital pulmonary airway malformation in a child: case report with an update of this association. J Pediatr Surg 42 (2007) E1-4.
[11]C.A. Hill, Bronchioloalveolar carcinoma: a review. Radiology 150 (1984) 15-20.
[12]D.C. Chhieng, J.F. Cangiarella, M.F. Zakowski, S. Goswami, J.M. Cohen, H.T. Yee, Use of thyroid transcription factor 1, PE-10, and cytokeratins 7 and 20 in discriminating between primary lung carcinomas and metastatic lesions in fine-needle aspiration biopsy specimens. Cancer 93 (2001) 330-336.



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B*CJOJQJaJphU%hH7*hL�B*CJOJQJaJph%hH7*hAB*CJOJQJaJphmucinous type (HEx400), formed of papillary clusters and comprised of lepidic growth (single cell row) atypical cells with hyperchromatic pleomorphic nuclei, and eosinophilic cytoplasm lining by alveolar wall 
Figure 1 C: Immunostaining for Cytokeratin 7 positivity in malignant cells 

Ҕ��
$d�a$gd{8�21�h:p�^o��. ��A!��"��#��$��%�������D|D<EndNote><Cite><Author>Cohen</Author><Year>1992</Year><RecNum>2146</RecNum><DisplayText>[1]</DisplayText><record><rec-number>2146</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">2146</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cohen, M. C.</author><author>Kaschula, R. O.</author></authors></contributors><auth-address>Department of Pathology, Red Cross War Memorial Children&apos;s Hospital, Rondebosch, South Africa.</auth-address><titles><title>Primary pulmonary tumors in childhood: a review of 31 years&apos; experience and the literature</title><secondary-title>Pediatr Pulmonol</secondary-title></titles><periodical><full-title>Pediatr Pulmonol</full-title></periodical><pages>222-32</pages><volume>14</volume><number>4</number><edition>1992/12/01</edition><keywords><keyword>Adolescent</keyword><keyword>Bronchial Neoplasms/pathology/ultrastructure</keyword><keyword>Carcinoma/ultrastructure</keyword><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Female</keyword><keyword>Fibrosarcoma/pathology</keyword><keyword>Hemangioma/pathology</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Lung Neoplasms/epidemiology/*pathology/ultrastructure</keyword><keyword>Male</keyword><keyword>Microscopy, Electron</keyword><keyword>Neoplasms, Germ Cell and Embryonal/pathology</keyword><keyword>Neoplasms, Glandular and Epithelial/pathology</keyword><keyword>Plasma Cell Granuloma, Pulmonary/*pathology</keyword></keywords><dates><year>1992</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>8755-6863 (Print)&#xD;1099-0496 (Linking)</isbn><accession-num>1336597</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=1336597</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Cohen</Author><Year>1992</Year><RecNum>2146</RecNum><record><rec-number>2146</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">2146</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cohen, M. C.</author><author>Kaschula, R. O.</author></authors></contributors><auth-address>Department of Pathology, Red Cross War Memorial Children&apos;s Hospital, Rondebosch, South Africa.</auth-address><titles><title>Primary pulmonary tumors in childhood: a review of 31 years&apos; experience and the literature</title><secondary-title>Pediatr Pulmonol</secondary-title></titles><periodical><full-title>Pediatr Pulmonol</full-title></periodical><pages>222-32</pages><volume>14</volume><number>4</number><edition>1992/12/01</edition><keywords><keyword>Adolescent</keyword><keyword>Bronchial Neoplasms/pathology/ultrastructure</keyword><keyword>Carcinoma/ultrastructure</keyword><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Female</keyword><keyword>Fibrosarcoma/pathology</keyword><keyword>Hemangioma/pathology</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Lung Neoplasms/epidemiology/*pathology/ultrastructure</keyword><keyword>Male</keyword><keyword>Microscopy, Electron</keyword><keyword>Neoplasms, Germ Cell and Embryonal/pathology</keyword><keyword>Neoplasms, Glandular and Epithelial/pathology</keyword><keyword>Plasma Cell Granuloma, Pulmonary/*pathology</keyword></keywords><dates><year>1992</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>8755-6863 (Print)&#xD;1099-0496 (Linking)</isbn><accession-num>1336597</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=1336597</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Cohen</Author><Year>1992</Year><RecNum>2146</RecNum><record><rec-number>2146</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">2146</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cohen, M. C.</author><author>Kaschula, R. O.</author></authors></contributors><auth-address>Department of Pathology, Red Cross War Memorial Children&apos;s Hospital, Rondebosch, South Africa.</auth-address><titles><title>Primary pulmonary tumors in childhood: a review of 31 years&apos; experience and the literature</title><secondary-title>Pediatr Pulmonol</secondary-title></titles><periodical><full-title>Pediatr Pulmonol</full-title></periodical><pages>222-32</pages><volume>14</volume><number>4</number><edition>1992/12/01</edition><keywords><keyword>Adolescent</keyword><keyword>Bronchial Neoplasms/pathology/ultrastructure</keyword><keyword>Carcinoma/ultrastructure</keyword><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Female</keyword><keyword>Fibrosarcoma/pathology</keyword><keyword>Hemangioma/pathology</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Lung Neoplasms/epidemiology/*pathology/ultrastructure</keyword><keyword>Male</keyword><keyword>Microscopy, Electron</keyword><keyword>Neoplasms, Germ Cell and Embryonal/pathology</keyword><keyword>Neoplasms, Glandular and Epithelial/pathology</keyword><keyword>Plasma Cell Granuloma, Pulmonary/*pathology</keyword></keywords><dates><year>1992</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>8755-6863 (Print)&#xD;1099-0496 (Linking)</isbn><accession-num>1336597</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=1336597</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Cohen</Author><Year>1992</Year><RecNum>2146</RecNum><record><rec-number>2146</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">2146</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cohen, M. C.</author><author>Kaschula, R. O.</author></authors></contributors><auth-address>Department of Pathology, Red Cross War Memorial Children&apos;s Hospital, Rondebosch, South Africa.</auth-address><titles><title>Primary pulmonary tumors in childhood: a review of 31 years&apos; experience and the literature</title><secondary-title>Pediatr Pulmonol</secondary-title></titles><periodical><full-title>Pediatr Pulmonol</full-title></periodical><pages>222-32</pages><volume>14</volume><number>4</number><edition>1992/12/01</edition><keywords><keyword>Adolescent</keyword><keyword>Bronchial Neoplasms/pathology/ultrastructure</keyword><keyword>Carcinoma/ultrastructure</keyword><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Female</keyword><keyword>Fibrosarcoma/pathology</keyword><keyword>Hemangioma/pathology</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Lung Neoplasms/epidemiology/*pathology/ultrastructure</keyword><keyword>Male</keyword><keyword>Microscopy, Electron</keyword><keyword>Neoplasms, Germ Cell and Embryonal/pathology</keyword><keyword>Neoplasms, Glandular and Epithelial/pathology</keyword><keyword>Plasma Cell Granuloma, Pulmonary/*pathology</keyword></keywords><dates><year>1992</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>8755-6863 (Print)&#xD;1099-0496 (Linking)</isbn><accession-num>1336597</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=1336597</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Cohen</Author><Year>1992</Year><RecNum>2146</RecNum><record><rec-number>2146</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">2146</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cohen, M. C.</author><author>Kaschula, R. O.</author></authors></contributors><auth-address>Department of Pathology, Red Cross War Memorial Children&apos;s Hospital, Rondebosch, South Africa.</auth-address><titles><title>Primary pulmonary tumors in childhood: a review of 31 years&apos; experience and the literature</title><secondary-title>Pediatr Pulmonol</secondary-title></titles><periodical><full-title>Pediatr Pulmonol</full-title></periodical><pages>222-32</pages><volume>14</volume><number>4</number><edition>1992/12/01</edition><keywords><keyword>Adolescent</keyword><keyword>Bronchial Neoplasms/pathology/ultrastructure</keyword><keyword>Carcinoma/ultrastructure</keyword><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Female</keyword><keyword>Fibrosarcoma/pathology</keyword><keyword>Hemangioma/pathology</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Lung Neoplasms/epidemiology/*pathology/ultrastructure</keyword><keyword>Male</keyword><keyword>Microscopy, Electron</keyword><keyword>Neoplasms, Germ Cell and Embryonal/pathology</keyword><keyword>Neoplasms, Glandular and Epithelial/pathology</keyword><keyword>Plasma Cell Granuloma, Pulmonary/*pathology</keyword></keywords><dates><year>1992</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>8755-6863 (Print)&#xD;1099-0496 (Linking)</isbn><accession-num>1336597</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=1336597</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Cohen</Author><Year>1992</Year><RecNum>2146</RecNum><record><rec-number>2146</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">2146</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cohen, M. C.</author><author>Kaschula, R. O.</author></authors></contributors><auth-address>Department of Pathology, Red Cross War Memorial Children&apos;s Hospital, Rondebosch, South Africa.</auth-address><titles><title>Primary pulmonary tumors in childhood: a review of 31 years&apos; experience and the literature</title><secondary-title>Pediatr Pulmonol</secondary-title></titles><periodical><full-title>Pediatr Pulmonol</full-title></periodical><pages>222-32</pages><volume>14</volume><number>4</number><edition>1992/12/01</edition><keywords><keyword>Adolescent</keyword><keyword>Bronchial Neoplasms/pathology/ultrastructure</keyword><keyword>Carcinoma/ultrastructure</keyword><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Female</keyword><keyword>Fibrosarcoma/pathology</keyword><keyword>Hemangioma/pathology</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Lung Neoplasms/epidemiology/*pathology/ultrastructure</keyword><keyword>Male</keyword><keyword>Microscopy, Electron</keyword><keyword>Neoplasms, Germ Cell and Embryonal/pathology</keyword><keyword>Neoplasms, Glandular and Epithelial/pathology</keyword><keyword>Plasma Cell Granuloma, Pulmonary/*pathology</keyword></keywords><dates><year>1992</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>8755-6863 (Print)&#xD;1099-0496 (Linking)</isbn><accession-num>1336597</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=1336597</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Cohen</Author><Year>1992</Year><RecNum>2146</RecNum><record><rec-number>2146</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">2146</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cohen, M. C.</author><author>Kaschula, R. O.</author></authors></contributors><auth-address>Department of Pathology, Red Cross War Memorial Children&apos;s Hospital, Rondebosch, South Africa.</auth-address><titles><title>Primary pulmonary tumors in childhood: a review of 31 years&apos; experience and the literature</title><secondary-title>Pediatr Pulmonol</secondary-title></titles><periodical><full-title>Pediatr Pulmonol</full-title></periodical><pages>222-32</pages><volume>14</volume><number>4</number><edition>1992/12/01</edition><keywords><keyword>Adolescent</keyword><keyword>Bronchial Neoplasms/pathology/ultrastructure</keyword><keyword>Carcinoma/ultrastructure</keyword><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Female</keyword><keyword>Fibrosarcoma/pathology</keyword><keyword>Hemangioma/pathology</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Lung Neoplasms/epidemiology/*pathology/ultrastructure</keyword><keyword>Male</keyword><keyword>Microscopy, Electron</keyword><keyword>Neoplasms, Germ Cell and Embryonal/pathology</keyword><keyword>Neoplasms, Glandular and Epithelial/pathology</keyword><keyword>Plasma Cell Granuloma, Pulmonary/*pathology</keyword></keywords><dates><year>1992</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>8755-6863 (Print)&#xD;1099-0496 (Linking)</isbn><accession-num>1336597</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=1336597</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Cohen</Author><Year>1992</Year><RecNum>2146</RecNum><record><rec-number>2146</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">2146</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cohen, M. C.</author><author>Kaschula, R. O.</author></authors></contributors><auth-address>Department of Pathology, Red Cross War Memorial Children&apos;s Hospital, Rondebosch, South Africa.</auth-address><titles><title>Primary pulmonary tumors in childhood: a review of 31 years&apos; experience and the literature</title><secondary-title>Pediatr Pulmonol</secondary-title></titles><periodical><full-title>Pediatr Pulmonol</full-title></periodical><pages>222-32</pages><volume>14</volume><number>4</number><edition>1992/12/01</edition><keywords><keyword>Adolescent</keyword><keyword>Bronchial Neoplasms/pathology/ultrastructure</keyword><keyword>Carcinoma/ultrastructure</keyword><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Female</keyword><keyword>Fibrosarcoma/pathology</keyword><keyword>Hemangioma/pathology</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Lung Neoplasms/epidemiology/*pathology/ultrastructure</keyword><keyword>Male</keyword><keyword>Microscopy, Electron</keyword><keyword>Neoplasms, Germ Cell and Embryonal/pathology</keyword><keyword>Neoplasms, Glandular and Epithelial/pathology</keyword><keyword>Plasma Cell Granuloma, Pulmonary/*pathology</keyword></keywords><dates><year>1992</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>8755-6863 (Print)&#xD;1099-0496 (Linking)</isbn><accession-num>1336597</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=1336597</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Cohen</Author><Year>1992</Year><RecNum>2146</RecNum><record><rec-number>2146</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">2146</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cohen, M. C.</author><author>Kaschula, R. O.</author></authors></contributors><auth-address>Department of Pathology, Red Cross War Memorial Children&apos;s Hospital, Rondebosch, South Africa.</auth-address><titles><title>Primary pulmonary tumors in childhood: a review of 31 years&apos; experience and the literature</title><secondary-title>Pediatr Pulmonol</secondary-title></titles><periodical><full-title>Pediatr Pulmonol</full-title></periodical><pages>222-32</pages><volume>14</volume><number>4</number><edition>1992/12/01</edition><keywords><keyword>Adolescent</keyword><keyword>Bronchial Neoplasms/pathology/ultrastructure</keyword><keyword>Carcinoma/ultrastructure</keyword><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Female</keyword><keyword>Fibrosarcoma/pathology</keyword><keyword>Hemangioma/pathology</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Lung Neoplasms/epidemiology/*pathology/ultrastructure</keyword><keyword>Male</keyword><keyword>Microscopy, Electron</keyword><keyword>Neoplasms, Germ Cell and Embryonal/pathology</keyword><keyword>Neoplasms, Glandular and Epithelial/pathology</keyword><keyword>Plasma Cell Granuloma, Pulmonary/*pathology</keyword></keywords><dates><year>1992</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>8755-6863 (Print)&#xD;1099-0496 (Linking)</isbn><accession-num>1336597</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=1336597</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Cohen</Author><Year>1992</Year><RecNum>2146</RecNum><record><rec-number>2146</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">2146</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cohen, M. C.</author><author>Kaschula, R. O.</author></authors></contributors><auth-address>Department of Pathology, Red Cross War Memorial Children&apos;s Hospital, Rondebosch, South Africa.</auth-address><titles><title>Primary pulmonary tumors in childhood: a review of 31 years&apos; experience and the literature</title><secondary-title>Pediatr Pulmonol</secondary-title></titles><periodical><full-title>Pediatr Pulmonol</full-title></periodical><pages>222-32</pages><volume>14</volume><number>4</number><edition>1992/12/01</edition><keywords><keyword>Adolescent</keyword><keyword>Bronchial Neoplasms/pathology/ultrastructure</keyword><keyword>Carcinoma/ultrastructure</keyword><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Female</keyword><keyword>Fibrosarcoma/pathology</keyword><keyword>Hemangioma/pathology</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Lung Neoplasms/epidemiology/*pathology/ultrastructure</keyword><keyword>Male</keyword><keyword>Microscopy, Electron</keyword><keyword>Neoplasms, Germ Cell and Embryonal/pathology</keyword><keyword>Neoplasms, Glandular and Epithelial/pathology</keyword><keyword>Plasma Cell Granuloma, Pulmonary/*pathology</keyword></keywords><dates><year>1992</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>8755-6863 (Print)&#xD;1099-0496 (Linking)</isbn><accession-num>1336597</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=1336597</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Cohen</Author><Year>1992</Year><RecNum>2146</RecNum><record><rec-number>2146</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">2146</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cohen, M. C.</author><author>Kaschula, R. O.</author></authors></contributors><auth-address>Department of Pathology, Red Cross War Memorial Children&apos;s Hospital, Rondebosch, South Africa.</auth-address><titles><title>Primary pulmonary tumors in childhood: a review of 31 years&apos; experience and the literature</title><secondary-title>Pediatr Pulmonol</secondary-title></titles><periodical><full-title>Pediatr Pulmonol</full-title></periodical><pages>222-32</pages><volume>14</volume><number>4</number><edition>1992/12/01</edition><keywords><keyword>Adolescent</keyword><keyword>Bronchial Neoplasms/pathology/ultrastructure</keyword><keyword>Carcinoma/ultrastructure</keyword><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Female</keyword><keyword>Fibrosarcoma/pathology</keyword><keyword>Hemangioma/pathology</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Lung Neoplasms/epidemiology/*pathology/ultrastructure</keyword><keyword>Male</keyword><keyword>Microscopy, Electron</keyword><keyword>Neoplasms, Germ Cell and Embryonal/pathology</keyword><keyword>Neoplasms, Glandular and Epithelial/pathology</keyword><keyword>Plasma Cell Granuloma, Pulmonary/*pathology</keyword></keywords><dates><year>1992</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>8755-6863 (Print)&#xD;1099-0496 (Linking)</isbn><accession-num>1336597</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=1336597</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Cohen</Author><Year>1992</Year><RecNum>2146</RecNum><record><rec-number>2146</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">2146</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cohen, M. C.</author><author>Kaschula, R. O.</author></authors></contributors><auth-address>Department of Pathology, Red Cross War Memorial Children&apos;s Hospital, Rondebosch, South Africa.</auth-address><titles><title>Primary pulmonary tumors in childhood: a review of 31 years&apos; experience and the literature</title><secondary-title>Pediatr Pulmonol</secondary-title></titles><periodical><full-title>Pediatr Pulmonol</full-title></periodical><pages>222-32</pages><volume>14</volume><number>4</number><edition>1992/12/01</edition><keywords><keyword>Adolescent</keyword><keyword>Bronchial Neoplasms/pathology/ultrastructure</keyword><keyword>Carcinoma/ultrastructure</keyword><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Female</keyword><keyword>Fibrosarcoma/pathology</keyword><keyword>Hemangioma/pathology</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Lung Neoplasms/epidemiology/*pathology/ultrastructure</keyword><keyword>Male</keyword><keyword>Microscopy, Electron</keyword><keyword>Neoplasms, Germ Cell and Embryonal/pathology</keyword><keyword>Neoplasms, Glandular and Epithelial/pathology</keyword><keyword>Plasma Cell Granuloma, Pulmonary/*pathology</keyword></keywords><dates><year>1992</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>8755-6863 (Print)&#xD;1099-0496 (Linking)</isbn><accession-num>1336597</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=1336597</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Cohen</Author><Year>1992</Year><RecNum>2146</RecNum><record><rec-number>2146</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">2146</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cohen, M. C.</author><author>Kaschula, R. O.</author></authors></contributors><auth-address>Department of Pathology, Red Cross War Memorial Children&apos;s Hospital, Rondebosch, South Africa.</auth-address><titles><title>Primary pulmonary tumors in childhood: a review of 31 years&apos; experience and the literature</title><secondary-title>Pediatr Pulmonol</secondary-title></titles><periodical><full-title>Pediatr Pulmonol</full-title></periodical><pages>222-32</pages><volume>14</volume><number>4</number><edition>1992/12/01</edition><keywords><keyword>Adolescent</keyword><keyword>Bronchial Neoplasms/pathology/ultrastructure</keyword><keyword>Carcinoma/ultrastructure</keyword><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Female</keyword><keyword>Fibrosarcoma/pathology</keyword><keyword>Hemangioma/pathology</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Lung Neoplasms/epidemiology/*pathology/ultrastructure</keyword><keyword>Male</keyword><keyword>Microscopy, Electron</keyword><keyword>Neoplasms, Germ Cell and Embryonal/pathology</keyword><keyword>Neoplasms, Glandular and Epithelial/pathology</keyword><keyword>Plasma Cell Granuloma, Pulmonary/*pathology</keyword></keywords><dates><year>1992</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>8755-6863 (Print)&#xD;1099-0496 (Linking)</isbn><accession-num>1336597</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=1336597</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Cohen</Author><Year>1992</Year><RecNum>2146</RecNum><record><rec-number>2146</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">2146</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cohen, M. C.</author><author>Kaschula, R. O.</author></authors></contributors><auth-address>Department of Pathology, Red Cross War Memorial Children&apos;s Hospital, Rondebosch, South Africa.</auth-address><titles><title>Primary pulmonary tumors in childhood: a review of 31 years&apos; experience and the literature</title><secondary-title>Pediatr Pulmonol</secondary-title></titles><periodical><full-title>Pediatr Pulmonol</full-title></periodical><pages>222-32</pages><volume>14</volume><number>4</number><edition>1992/12/01</edition><keywords><keyword>Adolescent</keyword><keyword>Bronchial Neoplasms/pathology/ultrastructure</keyword><keyword>Carcinoma/ultrastructure</keyword><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Female</keyword><keyword>Fibrosarcoma/pathology</keyword><keyword>Hemangioma/pathology</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Lung Neoplasms/epidemiology/*pathology/ultrastructure</keyword><keyword>Male</keyword><keyword>Microscopy, Electron</keyword><keyword>Neoplasms, Germ Cell and Embryonal/pathology</keyword><keyword>Neoplasms, Glandular and Epithelial/pathology</keyword><keyword>Plasma Cell Granuloma, Pulmonary/*pathology</keyword></keywords><dates><year>1992</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>8755-6863 (Print)&#xD;1099-0496 (Linking)</isbn><accession-num>1336597</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=1336597</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Cohen</Author><Year>1992</Year><RecNum>2146</RecNum><record><rec-number>2146</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">2146</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cohen, M. C.</author><author>Kaschula, R. O.</author></authors></contributors><auth-address>Department of Pathology, Red Cross War Memorial Children&apos;s Hospital, Rondebosch, South Africa.</auth-address><titles><title>Primary pulmonary tumors in childhood: a review of 31 years&apos; experience and the literature</title><secondary-title>Pediatr Pulmonol</secondary-title></titles><periodical><full-title>Pediatr Pulmonol</full-title></periodical><pages>222-32</pages><volume>14</volume><number>4</number><edition>1992/12/01</edition><keywords><keyword>Adolescent</keyword><keyword>Bronchial Neoplasms/pathology/ultrastructure</keyword><keyword>Carcinoma/ultrastructure</keyword><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Female</keyword><keyword>Fibrosarcoma/pathology</keyword><keyword>Hemangioma/pathology</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Lung Neoplasms/epidemiology/*pathology/ultrastructure</keyword><keyword>Male</keyword><keyword>Microscopy, Electron</keyword><keyword>Neoplasms, Germ Cell and Embryonal/pathology</keyword><keyword>Neoplasms, Glandular and Epithelial/pathology</keyword><keyword>Plasma Cell Granuloma, Pulmonary/*pathology</keyword></keywords><dates><year>1992</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>8755-6863 (Print)&#xD;1099-0496 (Linking)</isbn><accession-num>1336597</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=1336597</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Cohen</Author><Year>1992</Year><RecNum>2146</RecNum><record><rec-number>2146</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">2146</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cohen, M. C.</author><author>Kaschula, R. O.</author></authors></contributors><auth-address>Department of Pathology, Red Cross War Memorial Children&apos;s Hospital, Rondebosch, South Africa.</auth-address><titles><title>Primary pulmonary tumors in childhood: a review of 31 years&apos; experience and the literature</title><secondary-title>Pediatr Pulmonol</secondary-title></titles><periodical><full-title>Pediatr Pulmonol</full-title></periodical><pages>222-32</pages><volume>14</volume><number>4</number><edition>1992/12/01</edition><keywords><keyword>Adolescent</keyword><keyword>Bronchial Neoplasms/pathology/ultrastructure</keyword><keyword>Carcinoma/ultrastructure</keyword><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Female</keyword><keyword>Fibrosarcoma/pathology</keyword><keyword>Hemangioma/pathology</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Lung Neoplasms/epidemiology/*pathology/ultrastructure</keyword><keyword>Male</keyword><keyword>Microscopy, Electron</keyword><keyword>Neoplasms, Germ Cell and Embryonal/pathology</keyword><keyword>Neoplasms, Glandular and Epithelial/pathology</keyword><keyword>Plasma Cell Granuloma, Pulmonary/*pathology</keyword></keywords><dates><year>1992</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>8755-6863 (Print)&#xD;1099-0496 (Linking)</isbn><accession-num>1336597</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=1336597</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Cohen</Author><Year>1992</Year><RecNum>2146</RecNum><record><rec-number>2146</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">2146</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cohen, M. C.</author><author>Kaschula, R. O.</author></authors></contributors><auth-address>Department of Pathology, Red Cross War Memorial Children&apos;s Hospital, Rondebosch, South Africa.</auth-address><titles><title>Primary pulmonary tumors in childhood: a review of 31 years&apos; experience and the literature</title><secondary-title>Pediatr Pulmonol</secondary-title></titles><periodical><full-title>Pediatr Pulmonol</full-title></periodical><pages>222-32</pages><volume>14</volume><number>4</number><edition>1992/12/01</edition><keywords><keyword>Adolescent</keyword><keyword>Bronchial Neoplasms/pathology/ultrastructure</keyword><keyword>Carcinoma/ultrastructure</keyword><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Female</keyword><keyword>Fibrosarcoma/pathology</keyword><keyword>Hemangioma/pathology</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Lung Neoplasms/epidemiology/*pathology/ultrastructure</keyword><keyword>Male</keyword><keyword>Microscopy, Electron</keyword><keyword>Neoplasms, Germ Cell and Embryonal/pathology</keyword><keyword>Neoplasms, Glandular and Epithelial/pathology</keyword><keyword>Plasma Cell Granuloma, Pulmonary/*pathology</keyword></keywords><dates><year>1992</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>8755-6863 (Print)&#xD;1099-0496 (Linking)</isbn><acce�4Dssion-num>1336597</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=1336597</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Cohen</Author><Year>1992</Year><RecNum>2146</RecNum><record><rec-number>2146</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">2146</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cohen, M. C.</author><author>Kaschula, R. O.</author></authors></contributors><auth-address>Department of Pathology, Red Cross War Memorial Children&apos;s Hospital, Rondebosch, South Africa.</auth-address><titles><title>Primary pulmonary tumors in childhood: a review of 31 years&apos; experience and the literature</title><secondary-title>Pediatr Pulmonol</secondary-title></titles><periodical><full-title>Pediatr Pulmonol</full-title></periodical><pages>222-32</pages><volume>14</volume><number>4</number><edition>1992/12/01</edition><keywords><keyword>Adolescent</keyword><keyword>Bronchial Neoplasms/pathology/ultrastructure</keyword><keyword>Carcinoma/ultrastructure</keyword><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Female</keyword><keyword>Fibrosarcoma/pathology</keyword><keyword>Hemangioma/pathology</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Lung Neoplasms/epidemiology/*pathology/ultrastructure</keyword><keyword>Male</keyword><keyword>Microscopy, Electron</keyword><keyword>Neoplasms, Germ Cell and Embryonal/pathology</keyword><keyword>Neoplasms, Glandular and Epithelial/pathology</keyword><keyword>Plasma Cell Granuloma, Pulmonary/*pathology</keyword></keywords><dates><year>1992</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>8755-6863 (Print)&#xD;1099-0496 (Linking)</isbn><accession-num>1336597</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=1336597</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Cohen</Author><Year>1992</Year><RecNum>2146</RecNum><record><rec-number>2146</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">2146</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cohen, M. C.</author><author>Kaschula, R. O.</author></authors></contributors><auth-address>Department of Pathology, Red Cross War Memorial Children&apos;s Hospital, Rondebosch, South Africa.</auth-address><titles><title>Primary pulmonary tumors in childhood: a review of 31 years&apos; experience and the literature</title><secondary-title>Pediatr Pulmonol</secondary-title></titles><periodical><full-title>Pediatr Pulmonol</full-title></periodical><pages>222-32</pages><volume>14</volume><number>4</number><edition>1992/12/01</edition><keywords><keyword>Adolescent</keyword><keyword>Bronchial Neoplasms/pathology/ultrastructure</keyword><keyword>Carcinoma/ultrastructure</keyword><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Female</keyword><keyword>Fibrosarcoma/pathology</keyword><keyword>Hemangioma/pathology</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Lung Neoplasms/epidemiology/*pathology/ultrastructure</keyword><keyword>Male</keyword><keyword>Microscopy, Electron</keyword><keyword>Neoplasms, Germ Cell and Embryonal/pathology</keyword><keyword>Neoplasms, Glandular and Epithelial/pathology</keyword><keyword>Plasma Cell Granuloma, Pulmonary/*pathology</keyword></keywords><dates><year>1992</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>8755-6863 (Print)&#xD;1099-0496 (Linking)</isbn><accession-num>1336597</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=1336597</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Cohen</Author><Year>1992</Year><RecNum>2146</RecNum><record><rec-number>2146</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">2146</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cohen, M. C.</author><author>Kaschula, R. O.</author></authors></contributors><auth-address>Department of Pathology, Red Cross War Memorial Children&apos;s Hospital, Rondebosch, South Africa.</auth-address><titles><title>Primary pulmonary tumors in childhood: a review of 31 years&apos; experience and the literature</title><secondary-title>Pediatr Pulmonol</secondary-title></titles><periodical><full-title>Pediatr Pulmonol</full-title></periodical><pages>222-32</pages><volume>14</volume><number>4</number><edition>1992/12/01</edition><keywords><keyword>Adolescent</keyword><keyword>Bronchial Neoplasms/pathology/ultrastructure</keyword><keyword>Carcinoma/ultrastructure</keyword><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Female</keyword><keyword>Fibrosarcoma/pathology</keyword><keyword>Hemangioma/pathology</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Lung Neoplasms/epidemiology/*pathology/ultrastructure</keyword><keyword>Male</keyword><keyword>Microscopy, Electron</keyword><keyword>Neoplasms, Germ Cell and Embryonal/pathology</keyword><keyword>Neoplasms, Glandular and Epithelial/pathology</keyword><keyword>Plasma Cell Granuloma, Pulmonary/*pathology</keyword></keywords><dates><year>1992</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>8755-6863 (Print)&#xD;1099-0496 (Linking)</isbn><accession-num>1336597</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=1336597</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Cohen</Author><Year>1992</Year><RecNum>2146</RecNum><record><rec-number>2146</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">2146</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cohen, M. C.</author><author>Kaschula, R. O.</author></authors></contributors><auth-address>Department of Pathology, Red Cross War Memorial Children&apos;s Hospital, Rondebosch, South Africa.</auth-address><titles><title>Primary pulmonary tumors in childhood: a review of 31 years&apos; experience and the literature</title><secondary-title>Pediatr Pulmonol</secondary-title></titles><periodical><full-title>Pediatr Pulmonol</full-title></periodical><pages>222-32</pages><volume>14</volume><number>4</number><edition>1992/12/01</edition><keywords><keyword>Adolescent</keyword><keyword>Bronchial Neoplasms/pathology/ultrastructure</keyword><keyword>Carcinoma/ultrastructure</keyword><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Female</keyword><keyword>Fibrosarcoma/pathology</keyword><keyword>Hemangioma/pathology</keyword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Lung Neoplasms/epidemiology/*pathology/ultrastructure</keyword><keyword>Male</keyword><keyword>Microscopy, Electron</keyword><keyword>Neoplasms, Germ Cell and Embryonal/pathology</keyword><keyword>Neoplasms, Glandular and Epithelial/pathology</keyword><keyword>Plasma Cell Granuloma, Pulmonary/*pathology</keyword></keywords><dates><year>1992</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>8755-6863 (Print)&#xD;1099-0496 (Linking)</isbn><accession-num>1336597</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=1336597</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Cohen</Author><Year>1992</Year><RecNum>2146</RecNum><record><rec-number>2146</rec-number><foreign-keys><key app="EN" db-id="xst0fvfxdrz995e5fz9v2takwp00zatvrrw0">2146</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cohen, M. C.</author><author>Kaschula, R. 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