����JFIFXX�����    $.' ",#(7),01444'9=82<.342  2!!22222222222222222222222222222222222222222222222222����"��4�� ���,�PG"Z_�4�˷����kjز�Z�,F+��_z�,�© �����zh6�٨�ic�fu���#ډb���_�N�?��wQ���5-�~�I���8����TK<5o�Iv-�����k�_U_�����~b�M��d����Ӝ�U�Hh��?]��E�w��Q���k�{��_}qFW7HTՑ��Y��F�?_�'ϔ��_�Ջt��=||I ��6�έ"�����D���/[�k�9���Y�8ds|\���Ҿp6�Ҵ���]��.����6�z<�v��@]�i%��$j��~�g��J>��no����pM[me�i$[����s�o�ᘨ�˸ nɜG-�ĨU�ycP�3.DB�li�;��hj���x7Z^�N�h������N3u{�:j�x�힞��#M&��jL P@_���� P��&��o8������9�����@Sz6�t7#O�ߋ �s}Yf�T���lmr����Z)'N��k�۞p����w\�Tȯ?�8`�O��i{wﭹW�[�r�� ��Q4F�׊���3m&L�=��h3����z~��#�\�l :�F,j@�� ʱ�wQT����8�"kJO���6�֚l����}���R�>ډK���]��y����&����p�}b��;N�1�m�r$�|��7�>e�@B�TM*-iH��g�D�)� E�m�|�ؘbҗ�a��Ҿ����t4���o���G��*oCN�rP���Q��@z,|?W[0�����:�n,jWiE��W��$~/�hp\��?��{(�0���+�Y8rΟ�+����>S-S����VN;�}�s?.����� w�9��˟<���Mq4�Wv'��{)0�1mB��V����W[�����8�/<� �%���wT^�5���b��)iM� pg�N�&ݝ��VO~�q���u���9� ����!��J27����$O-���! �:�%H��� ـ����y�ΠM=t{!S�� oK8������t<����è:a������[�����ա�H���~��w��Qz`�po�^ ����Q��n� �,uu�C�$ ^���,������8�#��:�6��e�|~���!�3�3.�\0��q��o�4`.|� ����y�Q�`~;�d�ׯ,��O�Zw�������`73�v�܋�<���Ȏ�� ـ4k��5�K�a�u�=9Yd��$>x�A�&�� j0� ���vF��� Y�|�y��� ~�6�@c��1vOp�Ig����4��l�OD���L����� R���c���j�_�uX6��3?nk��Wy�f;^*B� ��@�~a�`��Eu������+���6�L��.ü>��}y���}_�O�6�͐�:�YrG�X��kG�����l^w���~㒶sy��Iu�!� W ��X��N�7BV��O��!X�2����wvG�R�f�T#�����t�/?���%8�^�W�aT��G�cL�M���I��(J����1~�8�?aT ���]����AS�E��(��*E}� 2��#I/�׍qz��^t�̔���b�Yz4x���t�){ OH��+(E��A&�N�������XT��o��"�XC��'���)}�J�z�p� ��~5�}�^����+�6����w��c��Q�|Lp�d�H��}�(�.|����k��c4^�"�����Z?ȕ ��a<�L�!039C� �Eu�C�F�Ew�ç ;�n?�*o���B�8�bʝ���'#Rqf���M}7����]����s2tcS{�\icTx;�\��7K���P���ʇ Z O-��~��c>"��?�������P��E��O�8��@�8��G��Q�g�a�Վ���󁶠�䧘��_%#r�>�1�z�a��eb��qcPѵ��n���#L��� =��׀t� L�7�`��V���A{�C:�g���e@�w1 Xp3�c3�ġ����p��M"'-�@n4���fG��B3�DJ�8[Jo�ߐ���gK)ƛ��$���� ���8�3�����+���� �����6�ʻ���� ���S�kI�*KZlT _`���?��K����QK�d����B`�s}�>���`��*�>��,*@J�d�oF*����弝��O}�k��s��]��y�ߘ��c1G�V���<=�7��7����6�q�PT��tXԀ�!9*4�4Tހ3XΛex�46���Y��D ����� �BdemDa����\�_l,��G�/���֌7���Y�](�xTt^%�GE�����4�}bT���ڹ�����;Y)���B�Q��u��>J/J �⮶.�XԄ��j�ݳ�+E��d ��r�5�_D�1 ��o�� �B�x�΢�#���<��W�����8���R6�@g�M�.��� dr�D��>(otU��@x=��~v���2� ӣ�d�oBd��3�eO�6�㣷�����ݜ6��6Y��Qz`��S��{���\P�~z m5{J/L��1������<�e�ͅPu�b�]�ϔ���'������f�b� Zpw��c`"��i���BD@:)ִ�:�]��hv�E�w���T�l��P���"Ju�}��وV J��G6��. J/�Qgl߭�e�����@�z�Zev2u�)]կ�����7x���s�M�-<ɯ�c��r�v�����@��$�ޮ}lk���a���'����>x��O\�ZFu>�����ck#��&:��`�$�ai�>2Δ����l���oF[h��lE�ܺ�Πk:)���`�� $[6�����9�����kOw�\|���8}������ބ:��񶐕��I�A1/�=�2[�,�!��.}gN#�u����b��� ~��݊��}34q����d�E��Lc��$��"�[q�U�硬g^��%B �z���r�pJ�ru%v\h1Y�ne`ǥ:g���pQM~�^�Xi� ��`S�:V29.�P���V�?B�k�� AEvw%�_�9C�Q����wKekPؠ�\�;Io d�{ ߞo�c1eP����\� `����E=���@K<�Y���eڼ�J���w����{av�F�'�M�@/J��+9p���|]�����Iw &`��8���&M�hg��[�{��Xj��%��Ӓ�$��(����ʹN���<>�I���RY���K2�NPlL�ɀ)��&e����B+ь����( � �JTx���_?EZ� }@ 6�U���뙢ط�z��dWI�n` D����噥�[��uV��"�G&Ú����2g�}&m��?ċ�"����Om#��������� ��{�ON��"S�X��Ne��ysQ���@Fn��Vg���dX�~nj�]J�<�K]:��FW��b�������62�=��5f����JKw��bf�X�55��~J �%^����:�-�QIE��P��v�nZum� z � ~ə ���� ���ة����;�f��\v���g�8�1��f24;�V���ǔ�)����9���1\��c��v�/'Ƞ�w�������$�4�R-��t���� e�6�/�ġ �̕Ecy�J���u�B���<�W�ַ~�w[B1L۲�-JS΂�{���΃������A��20�c#��@ 0!1@AP"#2Q`$3V�%45a6�FRUq��� ����^7ׅ,$n�������+��F�`��2X'��0vM��p�L=������5��8������u�p~���.�`r�����\���O��,ư�0oS ��_�M�����l���4�kv\JSd���x���SW�<��Ae�IX����������$I���w�:S���y���›R��9�Q[���,�5�;�@]�%���u�@ *ro�lbI �� ��+���%m:�͇ZV�����u�̉����θau<�fc�.����{�4Ա� �Q����*�Sm��8\ujqs]{kN���)qO�y�_*dJ�b�7���yQqI&9�ԌK!�M}�R�;������S�T���1���i[U�ɵz�]��U)V�S6���3$K{�ߊ<�(� E]Զ[ǼENg�����'�\?#)Dkf��J���o��v���'�%ƞ�&K�u�!��b�35LX�Ϸ��63$K�a�;�9>,R��W��3�3� d�JeTYE.Mϧ��-�o�j3+y��y^�c�������VO�9NV\nd�1 ��!͕_)a�v;����թ�M�lWR1��)El��P;��yوÏ�u 3�k�5Pr6<�⒲l�!˞*��u־�n�!�l:����UNW ��%��Chx8vL'��X�@��*��)���̮��ˍ��� ���D-M�+J�U�kvK����+�x8��cY������?�Ԡ��~3mo��|�u@[XeY�C�\Kp�x8�oC�C�&����N�~3-H���� ��MX�s�u<`���~"WL��$8ξ��3���a�)|:@�m�\���^�`�@ҷ)�5p+��6���p�%i)P M���ngc�����#0Aruz���RL+xSS?���ʮ}()#�t��mˇ!��0}}y����<�e� �-ή�Ԩ��X������ MF���ԙ~l L.3���}�V뽺�v�����멬��Nl�)�2����^�Iq��a��M��qG��T�����c3#������3U�Ǎ���}��לS�|qa��ڃ�+���-��2�f����/��bz��ڐ�� �ݼ[2�ç����k�X�2�* �Z�d���J�G����M*9W���s{��w���T��x��y,�in�O�v��]���n����P�$�JB@=4�OTI�n��e�22a\����q�d���%�$��(���:���: /*�K[PR�fr\nڙdN���F�n�$�4�[�� U�zƶ����� �mʋ���,�ao�u 3�z� �x��Kn����\[��VFmbE;�_U��&V�Gg�]L�۪&#n%�$ɯ�dG���D�TI=�%+AB�Ru#��b4�1�»x�cs�YzڙJG��f��Il��d�eF'T� iA��T���uC�$����Y��H?����[!G`}���ͪ� �纤Hv\������j�Ex�K���!���OiƸ�Yj�+u-<���'q����uN�*�r\��+�]���<�wOZ.fp�ێ��,-*)V?j-kÊ#�`�r��dV����(�ݽBk�����G�ƛk�QmUڗe��Z���f}|����8�8��a���i��3'J�����~G_�^���d�8w������ R�`(�~�.��u���l�s+g�bv���W���lGc}��u���afE~1�Ue������Z�0�8�=e�� f@/�jqEKQQ�J��oN��J���W5~M>$6�Lt�;$ʳ{���^��6�{����v6���ķܰg�V�cnn �~z�x�«�,2�u�?cE+Ș�H؎�%�Za�)���X>uW�Tz�Nyo����s���FQƤ��$��*�&�LLXL)�1�" L��eO��ɟ�9=���:t��Z���c��Ž���Y?�ӭV�wv�~,Y��r�ۗ�|�y��GaF�����C�����.�+� ���v1���fήJ�����]�S��T��B��n5sW}y�$��~z�'�c ��8 ��� ,! �p��VN�S��N�N�q��y8z˱�A��4��*��'������2n<�s���^ǧ˭P�Jޮɏ�U�G�L�J�*#��<�V��t7�8����TĜ>��i}K%,���)[��z�21z ?�N�i�n1?T�I�R#��m-�����������������1����lA�`��fT5+��ܐ�c�q՝��ʐ��,���3�f2U�եmab��#ŠdQ�y>\��)�SLY����w#��.���ʑ�f��� ,"+�w�~�N�'�c�O�3F�������N<���)j��&��,-� �љ���֊�_�zS���TǦ����w�>��?�������n��U仆�V���e�����0���$�C�d���rP �m�׈e�Xm�Vu� �L��.�bֹ��� �[Դaզ���*��\y�8�Է:�Ez\�0�Kq�C b��̘��cө���Q��=0Y��s�N��S.���3.���O�o:���#���v7�[#߫ ��5�܎�L���Er4���9n��COWlG�^��0k�%<���ZB���aB_���������'=��{i�v�l�$�uC���mƎҝ{�c㱼�y]���W�i ��ߧc��m�H� m�"�"�����;Y�ߝ�Z�Ǔ�����:S#��|}�y�,/k�Ld� TA�(�AI$+I3��;Y*���Z��}|��ӧO��d�v��..#:n��f>�>���ȶI�TX��� 8��y����"d�R�|�)0���=���n4��6ⲑ�+��r<�O�܂~zh�z����7ܓ�HH�Ga롏���nCo�>������a ���~]���R���̲c?�6(�q�;5%� |�uj�~z8R=X��I�V=�|{v�Gj\gc��q����z�؋%M�ߍ����1y��#��@f^���^�>N�����#x#۹��6�Y~�?�dfPO��{��P�4��V��u1E1J �*|���%���JN��`eWu�zk M6���q t[�� ��g�G���v��WIG��u_ft����5�j�"�Y�:T��ɐ���*�;� e5���4����q$C��2d�}���� _S�L#m�Yp��O�.�C�;��c����Hi#֩%+) �Ӎ��ƲV���SYź��g |���tj��3�8���r|���V��1#;.SQ�A[���S������#���`n�+���$��$I �P\[�@�s��(�ED�z���P��])8�G#��0B��[ى��X�II�q<��9�~[Z멜�Z�⊔IWU&A>�P~�#��dp<�?����7���c��'~���5 ��+$���lx@�M�dm��n<=e�dyX��?{�|Aef ,|n3�<~z�ƃ�uۧ�����P��Y,�ӥQ�*g�#먙R�\���;T��i,��[9Qi歉����c>]9�� ��"�c��P�� �Md?٥��If�ت�u��k��/����F��9�c*9��Ǎ:�ØF���z�n*�@|I�ށ9����N3{'��[�'ͬ�Ҳ4��#}��!�V� Fu��,�,mTIk���v C�7v���B�6k�T9��1�*l� '~��ƞF��lU��'�M ����][ΩũJ_�{�i�I�n��$���L�� j��O�dx�����kza۪��#�E��Cl����x˘�o�����V���ɞ�ljr��)�/,�߬h�L��#��^��L�ф�,íMƁe�̩�NB�L�����iL����q�}��(��q��6IçJ$�W�E$��:������=#����(�K�B����zђ <��K(�N�۫K�w��^O{!����)�H���>x�������lx�?>Պ�+�>�W���,Ly!_�D���Ō�l���Q�!�[ �S����J��1��Ɛ�Y}��b,+�Lo�x�ɓ)����=�y�oh�@�꥟/��I��ѭ=��P�y9��� �ۍYӘ�e+�p�Jnϱ?V\SO%�(�t� ���=?MR�[Ș�����d�/ ��n�l��B�7j� ��!�;ӥ�/�[-���A�>�dN�sLj ��,ɪv��=1c�.SQ�O3�U���ƀ�ܽ�E����������̻��9G�ϷD�7(�}��Ävӌ\�y�_0[w ���<΍>����a_��[0+�L��F.�޺��f�>oN�T����q;���y\��bՃ��y�jH�<|q-eɏ�_?_9+P���Hp$�����[ux�K w�Mw��N�ی'$Y2�=��q���KB��P��~������Yul:�[<����F1�2�O���5=d����]Y�sw:���Ϯ���E��j,_Q��X��z`H1,#II ��d�wr��P˂@�ZJV����y$�\y�{}��^~���[:N����ߌ�U�������O��d�����ؾe��${p>G��3c���Ė�lʌ�� ת��[��`ϱ�-W����dg�I��ig2��� ��}s ��ؤ(%#sS@���~���3�X�nRG�~\jc3�v��ӍL��M[JB�T��s3}��j�Nʖ��W����;7��ç?=X�F=-�=����q�ߚ���#���='�c��7���ڑW�I(O+=:uxq�������������e2�zi+�kuG�R��������0�&e�n���iT^J����~\jy���p'dtG��s����O��3����9* �b#Ɋ�� p������[Bws�T�>d4�ۧs���nv�n���U���_�~,�v����ƜJ1��s�� �QIz��)�(lv8M���U=�;����56��G���s#�K���MP�=��LvyGd��}�VwWBF�'�à �?MH�U�g2�� ����!�p�7Q��j��ڴ����=��j�u��� Jn�A s���uM������e��Ɔ�Ҕ�!)'��8Ϣ�ٔ��ޝ(��Vp���צ֖d=�IC�J�Ǡ{q������kԭ�߸���i��@K����u�|�p=..�*+����x�����z[Aqġ#s2a�Ɗ���RR�)*HRsi�~�a &f��M��P����-K�L@��Z��Xy�'x�{}��Zm+���:�)�) IJ�-i�u���� ���ܒH��'�L(7�y�GӜq���� j��� 6ߌg1�g�o���,kر���tY�?W,���p���e���f�OQS��!K�۟cҒA�|ս�j�>��=⬒��˧L[�� �߿2JaB~R��u�:��Q�] �0H~���]�7��Ƽ�I���(}��cq '�ήET���q�?f�ab���ӥvr� �)o��-Q��_'����ᴎo��K������;��V���o��%���~OK ����*��b�f:���-ťIR��`B�5!RB@���ï�� �u �̯e\�_U�_������� g�ES��3�������QT��a����x����U<~�c?�*�#]�MW,[8O�a�x��]�1bC|踤�P��lw5V%�)�{t�<��d��5���0i�XSU��m:��Z�┵�i�"��1�^B�-��P�hJ��&)O��*�D��c�W��vM��)����}���P��ܗ-q����\mmζZ-l@�}��a��E�6��F�@��&Sg@���ݚ�M����� ȹ 4����#p�\H����dYDo�H���"��\��..R�B�H�z_�/5˘����6��KhJR��P�mƶi�m���3�,#c�co��q�a)*Pt����R�m�k�7x�D�E�\Y�閣_X�<���~�)���c[[�BP����6�Yq���S��0����%_����;��Àv�~�| VS؇ ��'O0��F0��\���U�-�d@�����7�SJ*z��3n��y��P����O���������m�~�P�3|Y��ʉr#�C�<�G~�.,! ���bqx���h~0=��!ǫ�jy����l�O,�[B��~��|9��ٱ����Xly�#�i�B��g%�S��������tˋ���e���ې��\[d�t)��.+u�|1 ������#�~Oj����hS�%��i.�~X���I�H�m��0n���c�1uE�q��cF�RF�o���7� �O�ꮧ� ���ۛ{��ʛi5�rw?׌#Qn�TW��~?y$��m\�\o����%W� ?=>S�N@�� �Ʈ���R����N�)�r"C�:��:����� �����#��qb��Y�. �6[��2K����2u�Ǧ�HYR��Q�MV��� �G�$��Q+.>�����nNH��q�^��� ����q��mM��V��D�+�-�#*�U�̒ ���p욳��u:�������IB���m���PV@O���r[b= �� ��1U�E��_Nm�yKbN�O���U�}�the�`�|6֮P>�\2�P�V���I�D�i�P�O;�9�r�mAHG�W�S]��J*�_�G��+kP�2����Ka�Z���H�'K�x�W�MZ%�O�YD�Rc+o��?�q��Ghm��d�S�oh�\�D�|:W������UA�Qc yT�q������~^�H��/��#p�CZ���T�I�1�ӏT����4��"�ČZ�����}��`w�#�*,ʹ�� ��0�i��課�Om�*�da��^gJ݅{���l�e9uF#T�ֲ��̲�ٞC"�q���ߍ ոޑ�o#�XZTp����@ o�8��(jd��xw�]�,f���`~�|,s��^����f�1���t��|��m�򸄭/ctr��5s��7�9Q�4�H1꠲BB@l9@���C�����+�wp�xu�£Yc�9��?`@#�o�mH�s2��)�=��2�.�l����jg�9$�Y�S�%*L������R�Y������7Z���,*=�䷘$�������arm�o�ϰ���UW.|�r�uf����IGw�t����Zwo��~5 ��YյhO+=8fF�)�W�7�L9lM�̘·Y���֘YLf�큹�pRF���99.A �"wz��=E\Z���'a� 2��Ǚ�#;�'}�G���*��l��^"q��+2FQ� hj��kŦ��${���ޮ-�T�٭cf�|�3#~�RJ����t��$b�(R��(����r���dx� >U b�&9,>���%E\� Ά�e�$��'�q't��*�א���ެ�b��-|d���SB�O�O��$�R+�H�)�܎�K��1m`;�J�2�Y~9��O�g8=vqD`K[�F)k�[���1m޼c��n���]s�k�z$@��)!I �x՝"v��9=�ZA=`Ɠi �:�E��)`7��vI��}d�YI�_ �o�:ob���o ���3Q��&D&�2=�� �Ά��;>�h����y.*ⅥS������Ӭ�+q&����j|UƧ����}���J0��WW< ۋS�)jQR�j���Ư��rN)�Gű�4Ѷ(�S)Ǣ�8��i��W52���No˓� ۍ%�5brOn�L�;�n��\G����=�^U�dI���8$�&���h��'���+�(������cȁ߫k�l��S^���cƗjԌE�ꭔ��gF���Ȓ��@���}O���*;e�v�WV���YJ\�]X'5��ղ�k�F��b 6R�o՜m��i N�i����>J����?��lPm�U��}>_Z&�KK��q�r��I�D�Չ~�q�3fL�:S�e>���E���-G���{L�6p�e,8��������QI��h��a�Xa��U�A'���ʂ���s�+טIjP�-��y�8ۈZ?J$��W�P� ��R�s�]��|�l(�ԓ��sƊi��o(��S0��Y� 8�T97.�����WiL��c�~�dxc�E|�2!�X�K�Ƙਫ਼�$((�6�~|d9u+�qd�^3�89��Y�6L�.I�����?���iI�q���9�)O/뚅����O���X��X�V��ZF[�یgQ�L��K1���RҖr@v�#��X�l��F���Нy�S�8�7�kF!A��sM���^rkp�jP�DyS$N���q��nxҍ!U�f�!eh�i�2�m���`�Y�I�9r�6� �TF���C}/�y�^���Η���5d�'��9A-��J��>{�_l+�`��A���[�'��յ�ϛ#w:݅�%��X�}�&�PSt�Q�"�-��\縵�/����$Ɨh�Xb�*�y��BS����;W�ջ_mc�����vt?2}1�;qS�d�d~u:2k5�2�R�~�z+|HE!)�Ǟl��7`��0�<�,�2*���Hl-��x�^����'_TV�gZA�'j� ^�2Ϊ��N7t�����?w�� �x1��f��Iz�C-Ȗ��K�^q�;���-W�DvT�7��8�Z�������� hK�(P:��Q- �8�n�Z���܃e貾�<�1�YT<�,�����"�6{/ �?�͟��|1�:�#g��W�>$����d��J��d�B��=��jf[��%rE^��il:��B���x���Sּ�1հ��,�=��*�7 fcG��#q� �eh?��2�7�����,�!7x��6�n�LC�4x��},Geǝ�tC.��vS �F�43��zz\��;QYC,6����~;RYS/6���|2���5���v��T��i����������mlv��������&� �nRh^ejR�LG�f���? �ۉҬܦƩ��|��Ȱ����>3����!v��i�ʯ�>�v��オ�X3e���_1z�Kȗ\<������!�8���V��]��?b�k41�Re��T�q��mz��TiOʦ�Z��Xq���L������q"+���2ۨ��8}�&N7XU7Ap�d�X��~�׿��&4e�o�F��� �H����O���č�c�� 懴�6���͉��+)��v;j��ݷ�� �UV�� i��� j���Y9GdÒJ1��詞�����V?h��l����l�cGs�ځ�������y�Ac�����\V3�? �� ܙg�>qH�S,�E�W�[�㺨�uch�⍸�O�}���a��>�q�6�n6����N6�q������N ! 1AQaq�0@����"2BRb�#Pr���3C`��Scst���$4D���%Td�� ?���N����a��3��m���C���w��������xA�m�q�m���m������$����4n淿t'��C"w��zU=D�\R+w�p+Y�T�&�պ@��ƃ��3ޯ?�Aﶂ��aŘ���@-�����Q�=���9D��ռ�ѻ@��M�V��P��܅�G5�f�Y<�u=,EC)�<�Fy'�"�&�չ�X~f��l�KԆV��?�� �W�N����=(� �;���{�r����ٌ�Y���h{�١������jW����P���Tc�����X�K�r��}���w�R��%��?���E��m�� �Y�q|����\lEE4���r���}�lsI�Y������f�$�=�d�yO����p�����yBj8jU�o�/�S��?�U��*������ˍ�0������u�q�m [�?f����a�� )Q�>����6#������� ?����0UQ����,IX���(6ڵ[�DI�MNލ�c&���υ�j\��X�R|,4��� j������T�hA�e��^���d���b<����n�� �즇�=!���3�^�`j�h�ȓr��jẕ�c�,ٞX����-����a�ﶔ���#�$��]w�O��Ӫ�1y%��L�Y<�wg#�ǝ�̗`�x�xa�t�w��»1���o7o5��>�m뭛C���Uƃߜ}�C���y1Xνm�F8�jI���]����H���ۺиE@I�i;r�8ӭ����V�F�Շ| ��&?�3|x�B�MuS�Ge�=Ӕ�#BE5G�����Y!z��_e��q�р/W>|-�Ci߇�t�1ޯќd�R3�u��g�=0 5��[?�#͏��q�cf���H��{ ?u�=?�?ǯ���}Z��z���hmΔ�BFTW�����<�q�(v� ��!��z���iW]*�J�V�z��gX֧A�q�&��/w���u�gYӘa���; �i=����g:��?2�dž6�ى�k�4�>�Pxs����}������G�9��3 ���)gG�R<>r h�$��'nc�h�P��Bj��J�ҧH� -��N1���N��?��~��}-q!=��_2hc�M��l�vY%UE�@|�v����M2�.Y[|y�"Eï��K�ZF,�ɯ?,q�?v�M 80jx�"�;�9vk�����+ ֧�� �ȺU��?�%�vcV��mA�6��Qg^M����A}�3�nl� QRN�l8�kkn�'�����(��M�7m9و�q���%ޟ���*h$Zk"��$�9��: �?U8�Sl��,,|ɒ��xH(ѷ����Gn�/Q�4�P��G�%��Ա8�N��!� �&�7�;���eKM7�4��9R/%����l�c>�x;������>��C�:�����t��h?aKX�bhe�ᜋ^�$�Iհ �hr7%F$�E��Fd���t��5���+�(M6�t����Ü�UU|zW�=a�Ts�Tg������dqP�Q����b'�m���1{|Y����X�N��b �P~��F^F:����k6�"�j!�� �I�r�`��1&�-$�Bevk:y���#yw��I0��x��=D�4��tU���P�ZH��ڠ底taP��6����b>�xa����Q�#� WeF��ŮNj�p�J* mQ�N����*I�-*�ȩ�F�g�3 �5��V�ʊ�ɮ�a��5F���O@{���NX��?����H�]3��1�Ri_u��������ѕ�� ����0��� F��~��:60�p�͈�S��qX#a�5>���`�o&+�<2�D����: �������ڝ�$�nP���*)�N�|y�Ej�F�5ټ�e���ihy�Z �>���k�bH�a�v��h�-#���!�Po=@k̆IEN��@��}Ll?j�O������߭�ʞ���Q|A07x���wt!xf���I2?Z��<ץ�T���cU�j��]��陎Ltl �}5�ϓ��$�,��O�mˊ�;�@O��jE��j(�ا,��LX���LO���Ц�90�O �.����a��nA���7������j4 ��W��_ٓ���zW�jcB������y՗+EM�)d���N�g6�y1_x��p�$Lv:��9�"z��p���ʙ$��^��JԼ*�ϭ����o���=x�Lj�6�J��u82�A�H�3$�ٕ@�=Vv�]�'�qEz�;I˼��)��=��ɯ���x �/�W(V���p�����$ �m�������u�����񶤑Oqˎ�T����r��㠚x�sr�GC��byp�G��1ߠ�w e�8�$⿄����/�M{*}��W�]˷.�CK\�ުx���/$�WPw���r� |i���&�}�{�X� �>��$-��l���?-z���g����lΆ���(F���h�vS*���b���߲ڡn,|)mrH[���a�3�ר�[1��3o_�U�3�TC�$��(�=�)0�kgP���� ��u�^=��4 �WYCҸ:��vQ�ר�X�à��tk�m,�t*��^�,�}D*� �"(�I��9R����>`�`��[~Q]�#af��i6l��8���6�:,s�s�N6�j"�A4���IuQ��6E,�GnH��zS�HO�uk�5$�I�4��ؤ�Q9�@��C����wp�BGv[]�u�Ov���0I4���\��y�����Q�Ѹ��~>Z��8�T��a��q�ޣ;z��a���/��S��I:�ܫ_�|������>=Z����8:�S��U�I�J��"IY���8%b8���H��:�QO�6�;7�I�S��J��ҌAά3��>c���E+&jf$eC+�z�;��V����� �r���ʺ������my�e���aQ�f&��6�ND��.:��NT�vm�<- u���ǝ\MvZY�N�NT��-A�>jr!S��n�O 1�3�Ns�%�3D@���`������ܟ 1�^c<���� �a�ɽ�̲�Xë#�w�|y�cW�=�9I*H8�p�^(4���՗�k��arOcW�tO�\�ƍR��8����'�K���I�Q�����?5�>[�}��yU�ײ -h��=��% q�ThG�2�)���"ו3]�!kB��*p�FDl�A���,�eEi�H�f�Ps�����5�H:�Փ~�H�0Dت�D�I����h�F3�������c��2���E��9�H��5�zԑ�ʚ�i�X�=:m�xg�hd(�v����׊�9iS��O��d@0ڽ���:�p�5�h-��t�&���X�q�ӕ,��ie�|���7A�2���O%P��E��htj��Y1��w�Ѓ!����  ���� ࢽ��My�7�\�a�@�ţ�J �4�Ȼ�F�@o�̒?4�wx��)��]�P��~�����u�����5�����7X ��9��^ܩ�U;Iꭆ 5 �������eK2�7(�{|��Y׎ �V��\"���Z�1� Z�����}��(�Ǝ"�1S���_�vE30>���p;� ΝD��%x�W�?W?v����o�^V�i�d��r[��/&>�~`�9Wh��y�;���R��� ;;ɮT��?����r$�g1�K����A��C��c��K��l:�'��3 c�ﳯ*"t8�~l��)���m��+U,z��`(�>yJ�?����h>��]��v��ЍG*�{`��;y]��I�T� ;c��NU�fo¾h���/$���|NS���1�S�"�H��V���T���4��uhǜ�]�v;���5�͠x��'C\�SBpl���h}�N����� A�Bx���%��ޭ�l��/����T��w�ʽ]D�=����K���ž�r㻠l4�S�O?=�k �M:� ��c�C�a�#ha���)�ѐxc�s���gP�iG��{+���x���Q���I= �� z��ԫ+ �8"�k�ñ�j=|����c ��y��CF��/��*9ж�h{ �?4�o� ��k�m�Q�N�x��;�Y��4膚�a�w?�6�>e]�����Q�r�:����g�,i"�����ԩA�*M�<�G��b�if��l^M��5� �Ҩ�{����6J��ZJ�����P�*�����Y���ݛu�_4�9�I8�7���������,^ToR���m4�H��?�N�S�ѕw��/S��甍�@�9H�S�T��t�ƻ���ʒU��*{Xs�@����f�����֒Li�K{H�w^���������Ϥm�tq���s� ���ք��f:��o~s��g�r��ט� �S�ѱC�e]�x���a��) ���(b-$(�j>�7q�B?ӕ�F��hV25r[7 Y� }L�R��}����*sg+��x�r�2�U=�*'WS��ZDW]�WǞ�<��叓���{�$�9Ou4��y�90-�1�'*D`�c�^o?(�9��u���ݐ��'PI&� f�Jݮ�������:wS����jfP1F:X �H�9dԯ���˝[�_54 �}*;@�ܨ�� ð�yn�T���?�ןd�#���4rG�ͨ��H�1�|-#���Mr�S3��G�3�����)�.᧏3v�z֑��r����$G"�`j �1t��x0<Ɔ�Wh6�y�6��,œ�Ga��gA����y��b��)��h�D��ß�_�m��ü �gG;��e�v��ݝ�nQ� ��C����-�*��o���y�a��M��I�>�<���]obD��"�:���G�A��-\%LT�8���c�)��+y76���o�Q�#*{�(F�⽕�y����=���rW�\p���۩�c���A���^e6��K������ʐ�cVf5$�'->���ՉN"���F�"�UQ@�f��Gb~��#�&�M=��8�ט�JNu9��D��[̤�s�o�~������ G��9T�tW^g5y$b��Y'��س�Ǵ�=��U-2 #�MC�t(�i� �lj�@Q 5�̣i�*�O����s�x�K�f��}\��M{E�V�{�υ��Ƈ�����);�H����I��fe�Lȣr�2��>��W�I�Ȃ6������i��k�� �5�YOxȺ����>��Y�f5'��|��H+��98pj�n�.O�y�������jY��~��i�w'������l�;�s�2��Y��:'lg�ꥴ)o#'Sa�a�K��Z� �m��}�`169�n���"���x��I ��*+� }F<��cГ���F�P�������ֹ*�PqX�x۩��,� ��N�� �4<-����%����:��7����W���u�`����� $�?�I��&����o��o��`v�>��P��"��l���4��5'�Z�gE���8���?��[�X�7(��.Q�-��*���ތL@̲����v��.5���[��=�t\+�CNܛ��,g�SQnH����}*F�G16���&:�t��4ُ"A��̣��$�b �|����#rs��a�����T�� ]�<�j��BS�('$�ɻ� �wP;�/�n��?�ݜ��x�F��yUn�~mL*-�������Xf�wd^�a�}��f�,=t�׵i�.2/wpN�Ep8�OР���•��R�FJ� 55TZ��T �ɭ�<��]��/�0�r�@�f��V��V����Nz�G��^���7hZi����k��3�,kN�e|�vg�1{9]_i��X5y7� 8e]�U����'�-2,���e"����]ot�I��Y_��n�(JҼ��1�O ]bXc���Nu�No��pS���Q_���_�?i�~�x h5d'�(qw52] ��'ޤ�q��o1�R!���`ywy�A4u���h<קy���\[~�4�\ X�Wt/� 6�����n�F�a8��f���z �3$�t(���q��q�x��^�XWeN'p<-v�!�{�(>ӽDP7��ո0�y)�e$ٕv�Ih'Q�EA�m*�H��RI��=:��� ���4牢) �%_iN�ݧ�l]� �Nt���G��H�L��� ɱ�g<���1V�,�J~�ٹ�"K��Q�� 9�HS�9�?@��k����r�;we݁�]I�!{ �@�G�[�"��`���J:�n]�{�cA�E����V��ʆ���#��U9�6����j�#Y�m\��q�e4h�B�7��C�������d<�?J����1g:ٳ���=Y���D�p�ц� ׈ǔ��1�]26؜oS�'��9�V�FVu�P�h�9�xc�oq�X��p�o�5��Ա5$�9W�V(�[Ak�aY錎qf;�'�[�|���b�6�Ck��)��#a#a˙��8���=äh�4��2��C��4tm^ �n'c���]GQ$[Wҿ��i���vN�{Fu ��1�gx��1┷���N�m��{j-,��x�� Ūm�ЧS�[�s���Gna���䑴�� x�p 8<������97�Q���ϴ�v�aϚG��Rt�Һ׈�f^\r��WH�JU�7Z���y)�vg=����n��4�_)y��D'y�6�]�c�5̪�\� �PF�k����&�c;��cq�$~T�7j ���nç]�<�g ":�to�t}�159�<�/�8������m�b�K#g'I'.W�����6��I/��>v��\�MN��g���m�A�yQL�4u�Lj�j9��#44�t��l^�}L����n��R��!��t��±]��r��h6ٍ>�yҏ�N��fU�� ���� Fm@�8}�/u��jb9������he:A�y�ծw��GpΧh�5����l}�3p468��)U��d��c����;Us/�֔�YX�1�O2��uq�s��`hwg�r~�{ R��mhN��؎*q 42�*th��>�#���E����#��Hv�O����q�}�����6�e��\�,Wk�#���X��b>��p}�դ��3���T5��†��6��[��@�P�y*n��|'f�֧>�lư΂�̺����SU�'*�q�p�_S�����M�� '��c�6�����m�� ySʨ;M��r���Ƌ�m�Kxo,���Gm�P��A�G�:��i��w�9�}M(�^�V��$ǒ�ѽ�9���|���� �a����J�SQ�a���r�B;����}���ٻ֢�2�%U���c�#�g���N�a�ݕ�'�v�[�OY'��3L�3�;,p�]@�S��{ls��X�'���c�jw�k'a�.��}�}&�� �dP�*�bK=ɍ!����;3n�gΊU�ߴmt�'*{,=SzfD� A��ko~�G�aoq�_mi}#�m�������P�Xhύ����mxǍ�΂���巿zf��Q���c���|kc�����?���W��Y�$���_Lv����l߶��c���`?����l�j�ݲˏ!V��6����U�Ђ(A���4y)H���p�Z_�x��>���e��R��$�/�`^'3qˏ�-&Q�=?��CFVR �D�fV�9��{�8g�������n�h�(P"��6�[�D���< E�����~0<@�`�G�6����Hг�cc�� �c�K.5��D��d�B���`?�XQ��2��ٿyqo&+�1^� DW�0�ꊩ���G�#��Q�nL3��c���������/��x ��1�1[y�x�პCW��C�c�UĨ80�m�e�4.{�m��u���I=��f�����0QRls9���f���������9���~f�����Ǩ��a�"@�8���ȁ�Q����#c�ic������G��$���G���r/$W�(��W���V�"��m�7�[m�A�m����bo��D� j����۳� l���^�k�h׽����� ��#� iXn�v��eT�k�a�^Y�4�BN��ĕ��0 !01@Q"2AaPq3BR������?���@4�Q�����T3,���㺠�W�[=JK�Ϟ���2�r^7��vc�:�9 �E�ߴ�w�S#d���Ix��u��:��Hp��9E!�� V 2;73|F��9Y���*ʬ�F��D����u&���y؟��^EA��A��(ɩ���^��GV:ݜDy�`��Jr29ܾ�㝉��[���E;Fzx��YG��U�e�Y�C���� ����v-tx����I�sם�Ę�q��Eb�+P\ :>�i�C'�;�����k|z�رn�y]�#ǿb��Q��������w�����(�r|ӹs��[�D��2v-%��@;�8<a���[\o[ϧw��I!��*0�krs)�[�J9^��ʜ��p1)� "��/_>��o��<1����A�E�y^�C��`�x1'ܣn�p��s`l���fQ��):�l����b>�Me�jH^?�kl3(�z:���1ŠK&?Q�~�{�ٺ�h�y���/�[��V�|6��}�KbX����mn[-��7�5q�94�������dm���c^���h� X��5��<�eޘ>G���-�}�دB�ޟ� ��|�rt�M��V+�]�c?�-#ڛ��^ǂ}���Lkr���O��u�>�-D�ry� D?:ޞ�U��ǜ�7�V��?瓮�"�#���r��չģVR;�n���/_� ؉v�ݶe5d�b9��/O��009�G���5n�W����JpA�*�r9�>�1��.[t���s�F���nQ� V 77R�]�ɫ8����_0<՜�IF�u(v��4��F�k�3��E)��N:��yڮe��P�`�1}�$WS��J�SQ�N�j�ٺ��޵�#l���ј(�5=��5�lǏmoW�v-�1����v,W�mn��߀$x�<����v�j(����c]��@#��1������Ǔ���o'��u+����;G�#�޸��v-lη��/(`i⣍Pm^���ԯ̾9Z��F��������n��1��� ��]�[��)�'������:�֪�W��FC����� �B9،!?���]��V��A�Վ�M��b�w��G F>_DȬ0¤�#�QR�[V��kz���m�w�"��9ZG�7'[��=�Q����j8R?�zf�\a�=��O�U����*oB�A�|G���2�54 �p��.w7� �� ��&������ξxGHp� B%��$g�����t�Џ򤵍z���HN�u�Я�-�'4��0��;_��3 !01"@AQa2Pq#3BR������?��ʩca��en��^��8���<�u#��m*08r��y�N"�<�Ѳ0��@\�p��� �����Kv�D��J8�Fҽ� �f�Y��-m�ybX�NP����}�!*8t(�OqѢ��Q�wW�K��ZD��Δ^e��!� ��B�K��p~�����e*l}z#9ң�k���q#�Ft�o��S�R����-�w�!�S���Ӥß|M�l޶V��!eˈ�8Y���c�ЮM2��tk���� ������J�fS����Ö*i/2�����n]�k�\���|4yX�8��U�P.���Ы[���l��@"�t�<������5�lF���vU�����W��W��;�b�cД^6[#7@vU�xgZv��F�6��Q,K�v��� �+Ъ��n��Ǣ��Ft���8��0��c�@�!�Zq s�v�t�;#](B��-�nῃ~���3g������5�J�%���O������n�kB�ĺ�.r��+���#�N$?�q�/�s�6��p��a����a��J/��M�8��6�ܰ"�*������ɗud"\w���aT(����[��F��U՛����RT�b���n�*��6���O��SJ�.�ij<�v�MT��R\c��5l�sZB>F��<7�;EA��{��E���Ö��1U/�#��d1�a�n.1ě����0�ʾR�h��|�R��Ao�3�m3 ��%�� ���28Q� ��y��φ���H�To�7�lW>����#i`�q���c����a��� �m,B�-j����݋�'mR1Ήt�>��V��p���s�0IbI�C.���1R�ea�����]H�6����������4B>��o��](��$B���m�����a�!=��?�B� K�Ǿ+�Ծ"�n���K��*��+��[T#�{E�J�S����Q�����s�5�:�U�\wĐ�f�3����܆&�)����I���Ԇw��E T�lrTf6Q|R�h:��[K�� �z��c֧�G�C��%\��_�a�84��HcO�bi��ؖV��7H �)*ģK~Xhչ0��4?�0��� �E<���}3���#���u�?�� ��|g�S�6ꊤ�|�I#Hڛ� �ա��w�X��9��7���Ŀ%�SL��y6č��|�F�a 8���b��$�sק�h���b9RAu7�˨p�Č�_\*w��묦��F ����4D~�f����|(�"m���NK��i�S�>�$d7SlA��/�²����SL��|6N�}���S�˯���g��]6��; �#�.��<���q'Q�1|KQ$�����񛩶"�$r�b:���N8�w@��8$�� �AjfG|~�9F ���Y��ʺ��Bwؒ������M:I岎�G��`s�YV5����6��A �b:�W���G�q%l�����F��H���7�������Fsv7��k�� 403WebShell
403Webshell
Server IP : 172.67.215.126  /  Your IP : 172.69.214.218
Web Server : Apache/2.4.52 (Ubuntu)
System : Linux ip-172-31-19-221 6.8.0-1029-aws #31~22.04.1-Ubuntu SMP Thu Apr 24 21:16:18 UTC 2025 x86_64
User : www-data ( 33)
PHP Version : 8.1.28
Disable Function : NONE
MySQL : OFF  |  cURL : ON  |  WGET : ON  |  Perl : ON  |  Python : OFF  |  Sudo : ON  |  Pkexec : ON
Directory :  /efsdata/scitechnol.com/httpdocs/submission/uploads/

Upload File :
current_dir [ Writeable ] document_root [ Writeable ]

 

Command :

[ Back ]     

Current File : /efsdata/scitechnol.com/httpdocs/submission/uploads/2191-1-Manuscript-2014-08-07.doc
��ࡱ�>��	�����Q�Y�����������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������	

 !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPR����STUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~�Root Entry��������	�F CX�����@WordDocument������������(Data
��������������"1Table������u�]�	����bjbj:�:�	(X�*\X�*\|�>���������@@@@@$����dddP��<deo��@4&J&J&J&�'`�)�*��n�n�n�n�n�n�n$]r�uT�n-@z+�'�'z+z+�n@@J&J&Ho...z+F@J&@J&|hP.z+�n..$X��\J&������V���������+F�Y,hh5o0eo�Y�gu,guX�\�\ gu@�_�z+z+.z+z+z+z+z+�n�n.z+z+z+eoz+z+z+z+��������������������������������������������������������������������guz+z+z+z+z+z+z+z+z+�>:	Full Title:
�Aged Garlic Extract with Supplement is associated with Beneficial Effect on  HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed/20152239" Bone Mineral Density and Predicts Lack of Progression of Atherosclerosis: A Prospective Double Blinded Randomized Trial"

Authors: Naser Ahmadi MD PhD1, Vahid Nabavi MD1, Hussein Zughaib MD1, Nichole Patel BS1, Avinash Rathod MD1, Ferdinand Flores BS1, Song Mao MD1, Fereshteh Hajsadeghi MD1, Matthew Budoff MD1

Short Title:
�Aged Garlic Extract and Pleiotropic Effects�

  1 Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA
 


Address all correspondence including requests for reprints to:
Naser Ahmadi MD PhD FAHA FACC	David Geffen�School of Medicine, UCLA
1124 W. Carson Street, RB3
Torrance, CA, 90503
Phone: 310-803-0443
Fax: 310-222-5401
      Email:  HYPERLINK "mailto:ahmadi@ucla.edu" ahmadi@ucla.edu

Abstract:
Low levels of bone-mineral-density (BMD) are independently associated with the presence and severity of coronary-artery-calcium (CAC). This study evaluates the beneficial effects of aged-garlic-extract therapy with supplements (AGE-S) on levels of BMD, vascular-function, inflammation and CAC. Sixty subjects, randomized to a daily capsule of placebo vs. AGE-S inclusive of aged�garlic-extract (250mg) plus Vitamin-B12 (100microg), folic-acid (300microg), Vitamin-B6 (12.5mg) and l-arginine (100mg) underwent CAC, thoracic BMD (mg/cc), homocysteine and vascular-function measurement at baseline and 12 months. The postcuff-deflation temperature-rebound (TR), digital-thermal-monitoring index of vascular-function was assessed using a reactive-hyperemia-procedure. At 1-year, the mean increase in CAC and decrease in BMD was significantly lower in the AGE-S as compared to the placebo (p<0.05). After adjustment for risk-factors, the risk of CAC progression and reduced BMD was 65% and 68% less in AGE-S as compared to placebo (P<0.05). From baseline to 12 months, a significant correlation was noted between increase in CAC and decreases in BMD. Similarly, a significant correlation was noted between increase in TR and decrease in homocysteine with lack of decrease in BMD. The maximum beneficial effect of AGE-S was noted with increase in TR, lack of decrease in BMD and lack of progression of CAC. In conclusion, this study demonstrates AGE-S is independently associated with favorable effects on BMD levels and inflammation. A strong direct relation between increases in vascular-function, decrease in inflammation with lack of lowering in BMD levels as well as lack of CAC-progression in response to AGE-S was noted. 

Key Words: Coronary artery calcium, Bone Mineral Density, Aged Garlic Extract, Vascular function, Inflammation, Computed Tomography

Introduction:
      The prevalence of osteoporosis and atherosclerosis are increasing worldwide as result of increase in life expectancy and often these two major health care problems coexist in both genders. Osteoporosis has been shown to be associated with cardiovascular disease  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_1" \o "Farhat, 2006 #1" 1] , peripheral arterial disease  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_2" \o "Alexandersen, 2006 #3" 2] , stroke and cardiovascular mortality.  ADDIN EN.CITE <EndNote><Cite><Author>Qu</Author><Year>2011</Year><RecNum>5</RecNum><DisplayText>[3]</DisplayText><record><rec-number>5</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">5</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Qu, X.</author><author>Huang, X.</author><author>Jin, F.</author><author>Wang, H.</author><author>Hao, Y.</author><author>Tang, T.</author><author>Dai, K.</author></authors></contributors><auth-address>Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedics, Shanghai Ninth People&apos;s Hospital, Shanghai Jiaotong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, PR China.</auth-address><titles><title>Bone mineral density and all-cause, cardiovascular and stroke mortality: A meta-analysis of prospective cohort studies</title><secondary-title>Int J Cardiol</secondary-title><alt-title>International journal of cardiology</alt-title></titles><periodical><full-title>Int J Cardiol</full-title><abbr-1>International journal of cardiology</abbr-1></periodical><alt-periodical><full-title>Int J Cardiol</full-title><abbr-1>International journal of cardiology</abbr-1></alt-periodical><dates><year>2011</year><pub-dates><date>Nov 21</date></pub-dates></dates><isbn>1874-1754 (Electronic)&#xD;0167-5273 (Linking)</isbn><accession-num>22112679</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/22112679</url></related-urls></urls><electronic-resource-num>10.1016/j.ijcard.2011.10.114</electronic-resource-num></record></Cite></EndNote>[ HYPERLINK \l "_ENREF_3" \o "Qu, 2011 #5" 3]
      Quantitative computerized tomography (CT) is a well-accepted method for non-invasive quantitative measurement of bone mineral density (BMD) levels.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_4" \o "Lenchik, 2004 #6" 4] Our recent study revealed an excellent agreement between thoracic vertebrae BMD levels and lumbar vertebrae BMD levels measured by CT (r2=0.97, p=0.0001) with high accuracy and reproducibility.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_4" \o "Lenchik, 2004 #6" 4-6]  HYPERLINK \l "_ENREF_7" \o "Lenchik, 2004 #5809" The finding of these studies suggest the feasibility of simultaneous measurement of BMD levels and CAC from the same cardiac CT imaging which can reduce both costs and radiation dose.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_5" \o "Budoff, 2012 #7" 5]
      Previous studies revealed that aged garlic extract plus supplement (AGE-S) is associated with lack of progression of coronary atherosclerosis, increase in nitric oxide, improvement of vascular function and favorable effects on oxidative biomarkers.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_7" \o "Ahmadi, 2010 #9" 7] However, the potential impact of AGE-S on osteoporosis has not been studied. In this randomized study, we evaluated the effect of AGE-S on BMD levels, inflammatory markers, vascular function and coronary artery calcium (CAC).   
Subjects and Methods:
      This study is inclusive of 65 asymptomatic participants -aged 40-79 years- with Framingham risk scores (FRS) of 10-20%  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_8" \o "Wilson, 1998 #72" 8] and coronary artery calcium (CAC)>30 Agatston score, who were on chronic statin therapy and  were free of clinical coronary artery disease (CAD). Participants were randomized to a daily capsule of either placebo or AGE-S. AGE-S consists of AGE (250mg), vitamin B6 (12.5mg), B12 (100�g), folate (300�g) and L-arginine (100mg) (Kyolic 108, Wakunaga Nutritional Supplement, CA, USA). 
      All subjects received cardio-protective lifestyle education and their digital thermal monitoring (DTM) of vascular function, homocysteine, BMD levels and CAC were measured at baseline and 12-month follows up, 60 subjects completed the study. Demographics, blood pressure and routine blood work were assessed using standard techniques. The study protocol (NCT00860847) and consent form were approved by the IRB Committee Board of the Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA.
      CAC scanning was performed with an E-Speed electron beam scanner (EBCT) (GE-Imatron, South San Francisco, Calif., USA). The coronary arteries were imaged with 30-40 contiguous 3 mm slices during mid-diastole using ECG-triggering during a 15 second breath hold. CAC was considered present in a coronary artery when a density of >130 Hounsfield units (HU) was detected in >3contiguous pixels (>1mm2) overlying that coronary artery and was quantified using the previously described Agatston scoring method. CAC progression was defined as annual CAC progression>15%. ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_9" \o "Raggi, 2004 #11" 9] 
      BMD levels of 4 consecutive thoracic (T) vertebrae (T-7 to T-10) was measured using Z axis (sagittal views). An automated region of interest (ROI) with diameter of 6 mm, was located at the center of the trabecular region in each vertebral body, and average thoracic BMD levels in HU were measured. (Figure 1)  After calibration of measured BMD levels in HU with phantoms - using the N-Vivo�bone densitometry application (Image Analysis, Kentucky) - BMD levels in mg/cm3 were calculated. The intra- and inter-observer variability of repeated thoracic BMD levels measurements were 2.5% and 2.8%, respectively. ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_10" \o "Budoff, 2010 #12" 10]      
      Digital thermal mentoring of vascular function was measured in the morning in a quiet, dimmed room at a controlled ambient temperature of 23.5� to 25.0�C after an overnight fast of 10 hours. The measurements were obtained with the subjects in the supine position and after 30 minutes of rest. Subjects� blood pressure in the control arm was recorded in the sitting position 5 minutes before the DTM test.  DTM of vascular function was obtained during 5 minutes of stabilization, 5 minutes of cuff inflation to 50 mm Hg greater than systolic blood pressure, and 5 minutes of deflation using an automated, operator-independent protocol (VENDYS, Endothelix, and Houston, Texas).  Thermal changes during the 5-minute arm cuff-induced reactive hyperemia test were monitored continuously in the fingertip using VENDYS software. Vascular function was measured based on the amount of temperature rebound under area under the curve (TMP-AUC) in the occluded fingertip during the reactive hyperemia procedure. 
Statistical Analysis: All statistical analyses were performed using SAS 9.2 ( HYPERLINK "http://www.sas.com" www.sas.com, Cary, NC) and STATA 12.1( HYPERLINK "http://www.stata.com" www.stata.com, College Station, Texas). All continuous data are presented as a mean value � SD, and all categorical data are reported as a percentage or absolute number. Student's t tests and Chi-square tests were used to assess differences between groups. Logistic regression analyses were employed to assess the change in BMD level, homocysteine, vascular function and CAC in response to AGE-S. These analyses were adjusted for demographics, age, gender, conventional cardiovascular risk factors, body mass index and statin therapy. 
Results:
      At baseline, there were no significant differences in cardiovascular risk factors, age, gender, CAC, TR and levels of BMD between the groups. (Table 1)(P>0.05) After 1 year of the study, the mean decrease in levels of BMD was significantly lower in the AGE-S as compared to the placebo group (p<0.05). Similarly, significant increases in TR and lack of increase in CAC was noted in the AGE-S as compared to the placebo group (Table 2) (p<0.05).  After adjustment of conventional risk factors using logistic regression, the risk of CAC progression and reduced BMD levels was 65% and 68% less in AGE-S as compared to placebo cohort (Table 3)(P<0.05). The likelihood of combined increased in TR and BMD levels was 32.4 folds higher in AGE-S as compared to placebo. Similarly, likelihood of combined increased BMD levels and decrease in homocysteine was 2.39 folds higher with AGE-S. The likelihood of lack of progression in CAC and lack of regression with AGE-S was 9.1 folds higher as compared with Placebo. After adjustment for risk factors, the likelihood of simultaneous increased TR, decreased homocysteine, and lack of  reduction in BMD levels and CAC progression was  14.99 folds higher with AGE-S as compared with placebo (Table 4) (p<0.05). 
    From baseline to 12 months, there was a significant correlation between decreases in BMD and increases in CAC and (r2=0.52, p=0.0001) (Figure 2). A significant correlation was noted between increases in levels of BMD and increases in TR (r2=0.83, p=0.001) as well as decreases in homocysteine (r2=0.65, p=0.0001). The significant interaction between increased in TR and decreased in homocysteine with lack of decrease in BMD in response to AGE-S was noted (r2=0.89, p=0.01). Similarly, the significant interaction between increased in TR, decreased in homocysteine and increased in BMD levels with lack of CAC progression (r2=0.95, p=0.01). Maximum beneficial effect of AGE-S was noted with increase in TR, lack of decrease in BMD and lack of progression of CAC (Figure 3). 
Discussion:
     The current study demonstrates that: 1) there is a strong direct relationship between the lowering in BMD levels, and  CAC progression; 2) AGE-S is independently associated with lack of lowering in BMD levels, inflammatory biomarkers and lack of CAC progression, 3) A strong relation between increases in vascular-function, decrease in inflammation and lack of lowering in BMD levels in response to AGE-S was noted, and 4) AGE-S associated with decrease in homocysteine, increase in temperature rebound which predicted lack of lowering in BMD levels and lack of CAC progression.  HYPERLINK \l "_ENREF_12" \o "Ahmadi, 2010 #9"   
     Osteoporosis and atherosclerosis are prevalent and are a major public health concern. Both are inflammation diseases which the inflammatory processes and vascular endothelial function plays an important role in their pathogenesis and progression.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_11" \o "Libby, 2010 #13" 11-13] HYPERLINK \l "_ENREF_17" \o "McFarlane, 2004 #16"  Inflammatory cytokines such as IL-1� and IL-6, in addition to their role in atherosclerosis, are involved in bone turnover and IL-1� is a powerful stimulant of bone resorption; acting directly on osteoclasts and osteoclast precursors.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_12" \o "Czerny, 2010 #14" 12,  HYPERLINK \l "_ENREF_13" \o "McFarlane, 2004 #15" 13] HYPERLINK \l "_ENREF_17" \o "McFarlane, 2004 #16"     
     Increase in homocysteine and decrease in nitric oxide in response to inflammatory processes link osteoporosis and atherosclerosis. Hyperhomocysteinemia is associated with decrease in nitric oxide, endothelial cell ischemia, vascular endothelial dysfunction and plaque vulnerability. ADDIN EN.CITE <EndNote><Cite><Author>McCully</Author><Year>2011</Year><RecNum>19</RecNum><DisplayText>[14]</DisplayText><record><rec-number>19</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">19</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>McCully, K. S.</author></authors></contributors><auth-address>Veterans Affairs Medical Center, West Roxbury, MA 02132, USA. kilmer.mccully@va.gov</auth-address><titles><title>Chemical pathology of homocysteine. V. Thioretinamide, thioretinaco, and cystathionine synthase function in degenerative diseases</title><secondary-title>Ann Clin Lab Sci</secondary-title><alt-title>Annals of clinical and laboratory science</alt-title></titles><periodical><full-title>Ann Clin Lab Sci</full-title><abbr-1>Annals of clinical and laboratory science</abbr-1></periodical><alt-periodical><full-title>Ann Clin Lab Sci</full-title><abbr-1>Annals of clinical and laboratory science</abbr-1></alt-periodical><pages>301-14</pages><volume>41</volume><number>4</number><edition>2011/12/15</edition><keywords><keyword>Cystathionine beta-Synthase/*metabolism</keyword><keyword>*Disease</keyword><keyword>Homocysteine/*analogs &amp; derivatives/biosynthesis/chemistry/*metabolism</keyword><keyword>Humans</keyword><keyword>Oxidation-Reduction</keyword><keyword>Tretinoin/analogs &amp; derivatives/chemistry/metabolism</keyword><keyword>Vitamin B 12/*analogs &amp; derivatives/biosynthesis/chemistry/metabolism</keyword></keywords><dates><year>2011</year><pub-dates><date>Fall</date></pub-dates></dates><isbn>1550-8080 (Electronic)&#xD;0091-7370 (Linking)</isbn><accession-num>22166499</accession-num><work-type>Review</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/22166499</url></related-urls></urls><language>eng</language></record></Cite></EndNote>[ HYPERLINK \l "_ENREF_14" \o "McCully, 2011 #19" 14]  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_15" \o "Ersoy, 2008 #18" 15] 
     Previous studies showed that endothelial nitric oxide synthase (eNOS) deficiency caused a significant reduction in bone mass in mice  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_16" \o "Armour, 2001 #27" 16], whereas activation of nitric oxide and Akt, stimulated bone morphogenetic protein-2 (BMP-2) transcription and osteoblast differentiation. ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_17" \o "Garrett, 2001 #28" 17,  HYPERLINK \l "_ENREF_18" \o "Mundy, 1999 #29" 18] 
    Vascular endothelial function in addition to its known atheroprotective effects, plays a role in osteoblast function and bone turnover  ADDIN EN.CITE <EndNote><Cite><Author>McFarlane</Author><Year>2004</Year><RecNum>15</RecNum><DisplayText>[13]</DisplayText><record><rec-number>15</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">15</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>McFarlane, S. I.</author><author>Muniyappa, R.</author><author>Shin, J. J.</author><author>Bahtiyar, G.</author><author>Sowers, J. R.</author></authors></contributors><auth-address>Department of Internal Medicine, Division of Endocrinology, SUNY-Downstate, and Kings County Hospital Center, Brooklyn, NY 11203, USA. immgss@aol.com</auth-address><titles><title>Osteoporosis and cardiovascular disease: brittle bones and boned arteries, is there a link?</title><secondary-title>Endocrine</secondary-title><alt-title>Endocrine</alt-title></titles><periodical><full-title>Endocrine</full-title><abbr-1>Endocrine</abbr-1></periodical><alt-periodical><full-title>Endocrine</full-title><abbr-1>Endocrine</abbr-1></alt-periodical><pages>1-10</pages><volume>23</volume><number>1</number><keywords><keyword>Cardiovascular Diseases/drug therapy/*metabolism/pathology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Osteoporosis/drug therapy/*metabolism/pathology</keyword></keywords><dates><year>2004</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1355-008X (Print)&#xD;1355-008X (Linking)</isbn><accession-num>15034190</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/15034190</url></related-urls></urls><electronic-resource-num>10.1385/ENDO:23:1:01</electronic-resource-num></record></Cite></EndNote>[ HYPERLINK \l "_ENREF_13" \o "McFarlane, 2004 #15" 13] as well as regulation of bone remodeling by stimulating osteoblast differentiation, survival  as well as the progression of osteoporosis. ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_19" \o "Deckers, 2000 #17" 19] Furthermore, the impaired vascular endothelial function is associated with the presence and severity of subclinical coronary atherosclerosis measured as CAC as well as increased risk of subsequent atherosclerotic cardiovascular disease events. ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_20" \o "Yeboah, 2007 #20" 20] This study confirms previous studies and provided evidence that of linkage of improve in vascular endothelial function and homocysteine with lack of lowering in BMLD levels in response to AGE-S. 
    Recent studies report pleiotropic effects of statin therapy including improvement of endothelial function, stabilization of atherosclerotic plaques, decrease in oxidative stress and inflammation, inhibition of the thrombogenic response and beneficial effects on immune system, CNS, and bone. Statin therapy activates AMP-activated protein kinase (AMPK), ROK, phosphorylate protein kinase B (Akt); resulting in activation of eNOS and increase in nitric oxide production and BMP-2. ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_21" \o "Sowa, 2002 #30" 21,  HYPERLINK \l "_ENREF_22" \o "Ralston, 1995 #32" 22] HYPERLINK \l "_ENREF_36" \o "Sowa, 2002 #30"  HYPERLINK \l "_ENREF_36" \o "Laufs, 1997 #29"  HYPERLINK \l "_ENREF_36" \o "Klein-Nulend, 1995 #8"  By inhibition of HMG-CoA reductase and ROK in osteoblasts, statins enhances BMP-2 and eNOS expression; stimulating bone formation, acting as an anabolic for bone and promoting the mineralization of osteoblasts. ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_21" \o "Sowa, 2002 #30" 21] As a result, statin therapy simultaneously increases the bone and prevents atherosclerosis. ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_23" \o "Yamaguchi, 2002 #26" 23] A similar anti-inflammatory and anti-oxidative effects through nitric oxide pathway was noted in AGE-S. ADDIN EN.CITE <EndNote><Cite><Author>Amagase</Author><Year>2006</Year><RecNum>35</RecNum><DisplayText>[24]</DisplayText><record><rec-number>35</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">35</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Amagase, H.</author></authors></contributors><auth-address>Department of Research and Development, Wakunaga of America Co., Mission Viejo, CA 92691, USA. haru-amagase@wakunaga.com</auth-address><titles><title>Clarifying the real bioactive constituents of garlic</title><secondary-title>J Nutr</secondary-title><alt-title>The Journal of nutrition</alt-title></titles><periodical><full-title>J Nutr</full-title><abbr-1>The Journal of nutrition</abbr-1></periodical><alt-periodical><full-title>J Nutr</full-title><abbr-1>The Journal of nutrition</abbr-1></alt-periodical><pages>716S-725S</pages><volume>136</volume><number>3 Suppl</number><edition>2006/02/18</edition><keywords><keyword>Antioxidants/isolation &amp; purification</keyword><keyword>*Complementary Therapies</keyword><keyword>Garlic/*chemistry</keyword><keyword>Humans</keyword><keyword>Hypercholesterolemia/prevention &amp; control</keyword><keyword>Oils, Volatile/isolation &amp; purification</keyword><keyword>Pharmaceutical Preparations/metabolism</keyword><keyword>Plant Extracts/therapeutic use</keyword><keyword>*Plants, Medicinal</keyword><keyword>Safety</keyword></keywords><dates><year>2006</year><pub-dates><date>Mar</date></pub-dates></dates><isbn>0022-3166 (Print)&#xD;0022-3166 (Linking)</isbn><accession-num>16484550</accession-num><work-type>Review</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/16484550</url></related-urls></urls><language>eng</language></record></Cite></EndNote>[ HYPERLINK \l "_ENREF_24" \o "Amagase, 2006 #35" 24]     
    We previously reported that AGE-S, similar to statins, is associated with increases in vascular function, oxidized phospholipids (OxPL) on apolipoprotein B-100(apoB) particles detected by antibody E06 (OxPL/apoB) and lipoprotein (a) levels and lack of progression of CAC. ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_7" \o "Ahmadi, 2010 #9" 7] This study reveals direct association between changes in CAC and BMD levels in response to AGE-S. Furthermore, increases in vascular function and decrease in homocysteine in response to AGE-S is associated with lack of lowering in BMD levels and lack of CAC progression. These salutary effects have been associated with evidence of concomitant stabilization of atherosclerosis  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_25" \o "Fraley, 2009 #36" 25], as well as positive changes in BMD levels, which stimulates osteoblast proliferation, differentiation, mineralization and survival. 
Clinical Implication: Low BMD levels is independently associated with increased risks of atherosclerosis, ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_26" \o "Sumino, 2007 #22" 26] stroke ADDIN EN.CITE <EndNote><Cite><Author>Browner</Author><Year>1993</Year><RecNum>23</RecNum><DisplayText>[27]</DisplayText><record><rec-number>23</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">23</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Browner, W. S.</author><author>Pressman, A. R.</author><author>Nevitt, M. C.</author><author>Cauley, J. A.</author><author>Cummings, S. R.</author></authors></contributors><auth-address>Department of Epidemiology and Biostatistics, University of California, San Francisco.</auth-address><titles><title>Association between low bone density and stroke in elderly women. The study of osteoporotic fractures</title><secondary-title>Stroke</secondary-title><alt-title>Stroke; a journal of cerebral circulation</alt-title></titles><periodical><full-title>Stroke</full-title><abbr-1>Stroke; a journal of cerebral circulation</abbr-1></periodical><alt-periodical><full-title>Stroke</full-title><abbr-1>Stroke; a journal of cerebral circulation</abbr-1></alt-periodical><pages>940-6</pages><volume>24</volume><number>7</number><keywords><keyword>Aged</keyword><keyword>Alcohol Drinking</keyword><keyword>*Bone Density</keyword><keyword>Calcaneus</keyword><keyword>Cerebrovascular Disorders/*etiology</keyword><keyword>Databases, Bibliographic</keyword><keyword>Death Certificates</keyword><keyword>Female</keyword><keyword>Fractures, Bone/*complications</keyword><keyword>Humans</keyword><keyword>Medicare</keyword><keyword>Osteoporosis/*complications</keyword><keyword>Prospective Studies</keyword><keyword>Radius</keyword><keyword>Risk Factors</keyword><keyword>United States</keyword></keywords><dates><year>1993</year><pub-dates><date>Jul</date></pub-dates></dates><isbn>0039-2499 (Print)&#xD;0039-2499 (Linking)</isbn><accession-num>8322393</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/8322393</url></related-urls></urls></record></Cite></EndNote>[ HYPERLINK \l "_ENREF_27" \o "Browner, 1993 #23" 27] and cardiovascular death, ADDIN EN.CITE <EndNote><Cite><Author>von der Recke</Author><Year>1999</Year><RecNum>24</RecNum><DisplayText>[28]</DisplayText><record><rec-number>24</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">24</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>von der Recke, P.</author><author>Hansen, M. A.</author><author>Hassager, C.</author></authors></contributors><auth-address>Center for Clinical and Basic Research, Ballerup, Denmark.</auth-address><titles><title>The association between low bone mass at the menopause and cardiovascular mortality</title><secondary-title>Am J Med</secondary-title><alt-title>The American journal of medicine</alt-title></titles><periodical><full-title>Am J Med</full-title><abbr-1>The American journal of medicine</abbr-1></periodical><alt-periodical><full-title>Am J Med</full-title><abbr-1>The American journal of medicine</abbr-1></alt-periodical><pages>273-8</pages><volume>106</volume><number>3</number><keywords><keyword>*Bone Density</keyword><keyword>Cardiovascular Diseases/etiology/*mortality/physiopathology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>*Menopause</keyword><keyword>Middle Aged</keyword><keyword>Osteoporosis, Postmenopausal/*complications/physiopathology</keyword><keyword>Risk</keyword><keyword>Risk Factors</keyword><keyword>Spinal Fractures/complications/etiology</keyword></keywords><dates><year>1999</year><pub-dates><date>Mar</date></pub-dates></dates><isbn>0002-9343 (Print)&#xD;0002-9343 (Linking)</isbn><accession-num>10190374</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/10190374</url></related-urls></urls></record></Cite></EndNote>[ HYPERLINK \l "_ENREF_28" \o "von der Recke, 1999 #24" 28]. Barengolts et al.  ADDIN EN.CITE <EndNote><Cite><Author>Barengolts</Author><Year>1998</Year><RecNum>25</RecNum><DisplayText>[29]</DisplayText><record><rec-number>25</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">25</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Barengolts, E. I.</author><author>Berman, M.</author><author>Kukreja, S. C.</author><author>Kouznetsova, T.</author><author>Lin, C.</author><author>Chomka, E. V.</author></authors></contributors><auth-address>University of Illinois, VA West Side Medical Centers, Chicago 60612, USA.</auth-address><titles><title>Osteoporosis and coronary atherosclerosis in asymptomatic postmenopausal women</title><secondary-title>Calcif Tissue Int</secondary-title><alt-title>Calcified tissue international</alt-title></titles><periodical><full-title>Calcif Tissue Int</full-title><abbr-1>Calcified tissue international</abbr-1></periodical><alt-periodical><full-title>Calcif Tissue Int</full-title><abbr-1>Calcified tissue international</abbr-1></alt-periodical><pages>209-13</pages><volume>62</volume><number>3</number><keywords><keyword>Absorptiometry, Photon</keyword><keyword>Aged</keyword><keyword>*Bone Density</keyword><keyword>Calcium/metabolism</keyword><keyword>Coronary Artery Disease/*complications/metabolism/pathology</keyword><keyword>Coronary Vessels/metabolism</keyword><keyword>Female</keyword><keyword>Femur/pathology/radiography</keyword><keyword>Humans</keyword><keyword>Lumbar Vertebrae/pathology/radiography</keyword><keyword>Middle Aged</keyword><keyword>Osteoporosis, Postmenopausal/*complications/metabolism/pathology</keyword><keyword>*Postmenopause</keyword><keyword>Tomography, X-Ray Computed</keyword></keywords><dates><year>1998</year><pub-dates><date>Mar</date></pub-dates></dates><isbn>0171-967X (Print)&#xD;0171-967X (Linking)</isbn><accession-num>9501953</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/9501953</url></related-urls></urls></record></Cite></EndNote>[ HYPERLINK \l "_ENREF_29" \o "Barengolts, 1998 #25" 29] in their matched case control study on 45 postmenopausal women with and without low BMD levels, reported that the mean CAC was significantly higher in those with lower levels of BMD as compared to matched control group independent of age and body mass index. The current study highlights the important role of AGE-S in simultaneous cardioprotection and prevention of osteoporosis by improving endothelial function and its anti-inflammatory effects.
      This study has several limitations.  The study sample size was small; however this study clearly demonstrates the beneficial effects of AGE-S on BMD levels, vascular endothelial function, inflammatory biomarkers and CAC progression.  Further studies are needed to assess the long-term effect of AGE-S on BMD levels on major adverse cardiovascular events (MACE) as pathologic fractures. 
Conclusion: 
    AGE-S is associated with favorable effects on BMD levels, and predicted lack of CAC progression. AGE-S associated with decrease in homocysteine, increase in temperature rebound which predicted lack of lowering in BMD levels and lack of CAC progression.  HYPERLINK \l "_ENREF_12" \o "Ahmadi, 2010 #9" This highlights the role of AGE-S in simultaneous cardioprotection and prevention of osteoporosis by improving endothelial function and its anti-inflammatory effects.
Financial support�
This study was supported by a grant from Wakanuga Inc. of America, the manufacturer of the garlic formulation used in this study. 
Conflict of interest statement�
Dr. Budoff has received grant support from Wakanuga. Other co-authors have no disclosures.
Acknowledgments�
All authors have made substantial contributions to the conception and drafting and have approved the final version of this�manuscript.
References:
 ADDIN EN.REFLIST 1.	Farhat, G.N., et al., Volumetric and areal bone mineral density measures are associated with cardiovascular disease in older men and women: the health, aging, and body composition study. Calcif Tissue Int, 2006. 79(2): p. 102-11.
2.	Alexandersen, P., et al., Associations between aortic calcification and components of body composition in elderly men. Obesity (Silver Spring), 2006. 14(9): p. 1571-8.
3.	Qu, X., et al., Bone mineral density and all-cause, cardiovascular and stroke mortality: A meta-analysis of prospective cohort studies. Int J Cardiol, 2011.
4.	Lenchik, L., et al., Measurement of trabecular bone mineral density in the thoracic spine using cardiac gated quantitative computed tomography. J Comput Assist Tomogr, 2004. 28(1): p. 134-9.
5.	Budoff, M.J., et al., Trabecular bone mineral density measurement using thoracic and lumbar quantitative computed tomography. Acad Radiol, 2012. 19(2): p. 179-83.
6.	Wong, M., et al., Validation of thoracic quantitative computed tomography as a method to measure bone mineral density. Calcif Tissue Int, 2005. 76(1): p. 7-10.
7.	Ahmadi, N., et al., Relation of oxidative biomarkers, vascular dysfunction, and progression of coronary artery calcium. Am J Cardiol, 2010. 105(4): p. 459-66.
8.	Wilson, P.W., et al., Prediction of coronary heart disease using risk factor categories. Circulation, 1998. 97(18): p. 1837-47.
9.	Raggi, P., T.Q. Callister, and L.J. Shaw, Progression of coronary artery calcium and risk of first myocardial infarction in patients receiving cholesterol-lowering therapy. Arterioscler Thromb Vasc Biol, 2004. 24(7): p. 1272-7.
10.	Budoff, M.J., et al., Measurement of thoracic bone mineral density with quantitative CT. Radiology, 2010. 257(2): p. 434-40.
11.	Libby, P., et al., Inflammation in atherosclerosis: transition from theory to practice. Circ J, 2010. 74(2): p. 213-20.
12.	Czerny, B., et al., The association of IL-1beta, IL-2, and IL-6 gene polymorphisms with bone mineral density and osteoporosis in postmenopausal women. Eur J Obstet Gynecol Reprod Biol, 2010. 149(1): p. 82-5.
13.	McFarlane, S.I., et al., Osteoporosis and cardiovascular disease: brittle bones and boned arteries, is there a link? Endocrine, 2004. 23(1): p. 1-10.
14.	McCully, K.S., Chemical pathology of homocysteine. V. Thioretinamide, thioretinaco, and cystathionine synthase function in degenerative diseases. Ann Clin Lab Sci, 2011. 41(4): p. 301-14.
15.	Ersoy, C., et al., The effect of metformin treatment on VEGF and PAI-1 levels in obese type 2 diabetic patients. Diabetes Res Clin Pract, 2008. 81(1): p. 56-60.
16.	Armour, K.E., et al., Defective bone formation and anabolic response to exogenous estrogen in mice with targeted disruption of endothelial nitric oxide synthase. Endocrinology, 2001. 142(2): p. 760-6.
17.	Garrett, I.R., G. Gutierrez, and G.R. Mundy, Statins and bone formation. Curr Pharm Des, 2001. 7(8): p. 715-36.
18.	Mundy, G., et al., Stimulation of bone formation in vitro and in rodents by statins. Science, 1999. 286(5446): p. 1946-9.
19.	Deckers, M.M., et al., Expression of vascular endothelial growth factors and their receptors during osteoblast differentiation. Endocrinology, 2000. 141(5): p. 1667-74.
20.	Yeboah, J., et al., Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study. Circulation, 2007. 115(18): p. 2390-7.

21.	Sowa, H., et al., Smad3 promotes alkaline phosphatase activity and mineralization of osteoblastic MC3T3-E1 cells. J Bone Miner Res, 2002. 17(7): p. 1190-9.
22.	Ralston, S.H., et al., Nitric oxide: a cytokine-induced regulator of bone resorption. J Bone Miner Res, 1995. 10(7): p. 1040-9.
23.	Yamaguchi, T., et al., Plasma lipids and osteoporosis in postmenopausal women. Endocr J, 2002. 49(2): p. 211-7.
24.	Amagase, H., Clarifying the real bioactive constituents of garlic. J Nutr, 2006. 136(3 Suppl): p. 716S-725S.
25.	Fraley, A.E., et al., Relationship of oxidized phospholipids and biomarkers of oxidized low-density lipoprotein with cardiovascular risk factors, inflammatory biomarkers, and effect of statin therapy in patients with acute coronary syndromes: Results from the MIRACL (Myocardial Ischemia Reduction With Aggressive Cholesterol Lowering) trial. J Am Coll Cardiol, 2009. 53(23): p. 2186-96.
26.	Sumino, H., et al., Relationship between brachial arterial endothelial function and lumbar spine bone mineral density in postmenopausal women. Circ J, 2007. 71(10): p. 1555-9.
27.	Browner, W.S., et al., Association between low bone density and stroke in elderly women. The study of osteoporotic fractures. Stroke, 1993. 24(7): p. 940-6.
28.	von der Recke, P., M.A. Hansen, and C. Hassager, The association between low bone mass at the menopause and cardiovascular mortality. Am J Med, 1999. 106(3): p. 273-8.
29.	Barengolts, E.I., et al., Osteoporosis and coronary atherosclerosis in asymptomatic postmenopausal women. Calcif Tissue Int, 1998. 62(3): p. 209-13.











-- PAGE   \* MERGEFORMAT - 1 ---


-- 9--




!4>DYZ���������sbsD&;h�FhmH0J5�CJOJQJ\�^JaJfHq�
����;h�Fh(g�0J5�CJOJQJ\�^JaJfHq�
���� h�Fh�"CJOJQJ^JaJ)jh�Fh�"CJOJQJU^JaJ&h�Fh�4,5�CJOJQJ\�^JaJ&h�Fh�GQ5�CJOJQJ\�^JaJ&h�FhmH5�CJOJQJ\�^JaJ&h�Fh_`�5�CJOJQJ\�^JaJ&h�Fhwa75�CJOJQJ\�^JaJ&h�Fh�#X5�CJOJQJ\�^JaJ		�	�	�		


d
f
g
h
�
�
��������������
�M�hd��^�hgd�l�m$	d�gd�3�m$�h��d��^�h`��gd�3�m$d��gd�3�m$$�vd��^�va$gd�3�m$$d��a$gd�|Lm$$d��a$gd_`�m$$d��a$gd�3�m$������������������������������������������������������������������������������������������������������������������������������������������
				۲�m�I8$&h�Fhwa75�CJOJQJ\�^JaJ h�Fh_`�CJOJQJ^JaJGh�Fhwa70J5�>*B*CJOJQJ\�^JaJfHph�q�
����Ah�0J5�>*B*CJOJQJ\�^JaJfHph�q�
����Gh�Fh_`�0J5�>*B*CJOJQJ\�^JaJfHph�q�
����Pjh�Fh�"0J5�>*B*CJOJQJU\�^JaJfHph�q�
����Gh�Fh1�0J5�>*B*CJOJQJ\�^JaJfHph�q�
����			(	+	,	=	>	R	S	\	]	e	f	y	z	�	�	�	�	�	�	�	�	�	�	�	�	�	�	�	���ͻ����������v��b&h�Fhwa75�CJOJQJ\�^JaJ h�Fh�|LCJOJQJ^JaJ#h�Fh�+1CJH*OJQJ^JaJ h�Fh�+1CJOJQJ^JaJ h�Fh��CJOJQJ^JaJ#h�Fh�c�CJH*OJQJ^JaJ h�Fh�c�CJOJQJ^JaJ h�Fh�#XCJOJQJ^JaJ h�Fhwa7CJOJQJ^JaJ�	�	�	�	
	




`
a
d
f
g
h
�
�
��Ħؕ�r�a�P�@0ah�Fh�#X6�OJQJ]�^Jh�Fh�3�6�OJQJ]�^J h�Fh�0GCJOJQJ^JaJ h�Fh�#XCJOJQJ^JaJ#h�Fh�#XCJH*OJQJ^JaJ h�Fhwa7CJOJQJ^JaJ h�Fhn�CJOJQJ^JaJ;h�FhR70J!5�CJOJQJ\�^JaJfHq�
����&h�FhR75�CJOJQJ\�^JaJ&h�Fhwa75�CJOJQJ\�^JaJ&h�Fh��5�CJOJQJ\�^JaJ�
�
�
/4@ANOst��������޶��ޏ~�hM9&h�FhlS�6�CJOJQJ]�^JaJ4jh�Fh�"0JCJOJPJQJU\�^JaJ+h�Fh�#X0JCJOJPJQJ\�^JaJ h�Fh�"CJOJQJ^JaJ)jh�Fh�"CJOJQJU^JaJ#h�Fh��CJOJQJ\�^JaJ'h�Fh��CJOJPJQJ\�^JaJ'h�Fh�l�CJOJPJQJ\�^JaJ'h�Fh�#XCJOJPJQJ\�^JaJh�l�CJOJQJ^JaJ�
/A���KL���v���������������$d��a$gd�B�m$$dh�a$gdQgm$$d��-D9DM�
����a$gd)�m$d��-D9DM�
����gd�3�m$$$dh�a$gd}B�d��gd�3�m$�hd��^�hgd�3�m$�����������JKQR�


������z�����i�i�iW>1h�Fh�3CJOJQJ^JaJfHq�
����#h�Fh�3CJOJQJ\�^JaJ h�Fh�*CJOJQJ^JaJ h�Fhy5�CJOJQJ^JaJ h�Fh�M�CJOJQJ^JaJ h�Fh��CJOJQJ^JaJ+h�Fh�*5�B*CJOJQJ\�aJph�+h�FhlS�5�B*CJOJQJ\�aJph�+h�Fh)�5�B*CJOJQJ\�aJph� hO�5�CJOJQJ\�^JaJ





2
3
J
K
b
c
z
{
�
�
�
'(����	�����������}l}[}l}l}[}l}[I#h�Fh�3CJOJQJ\�^JaJ h�Fh�M�CJOJQJ^JaJ h�Fh1K�CJOJQJ^JaJ h�Fh�3CJOJQJ^JaJ1h�Fh1K�CJOJQJ^JaJfHq�
����1h�Fh�3CJOJQJ^JaJfHq�
����Fh�Fh�30JCJOJQJ^JaJeh@fHq�
����r��@5h�Fh�30JCJOJQJ^JaJfHq�
����	/09Glouv�����v[@['1h�Fh�V`CJOJQJ^JaJfHq�
����5h�Fhr/i0JCJOJQJ^JaJfHq�
����5h�Fh�*�0JCJOJQJ^JaJfHq�
����5h�Fh�n�0JCJOJQJ^JaJfHq�
����1h�Fh�)�CJOJQJ^JaJfHq�
����1h�Fh�*�CJOJQJ^JaJfHq�
����1h�Fh�n�CJOJQJ^JaJfHq�
���� h�Fh�n�CJOJQJ^JaJ#h�Fh)�CJOJQJ\�^JaJ��������������*�ʹ���͛iP͛7�7i�曂�1h�FhYd
CJOJQJ^JaJfHq�
����1h�Fhr/iCJOJQJ^JaJfHq�
����1h�Fho�CJOJQJ^JaJfHq�
����1h�Fh�M�CJOJQJ^JaJfHq�
����1h�Fh�;�CJOJQJ^JaJfHq�
����1h�Fh�n�CJOJQJ^JaJfHq�
����1h�Fh�V`CJOJQJ^JaJfHq�
����1h�Fh�S/CJOJQJ^JaJfHq�
����*>HIKLVnp����������ͼ���r�r�rarM< h�FhN�CJOJQJ^JaJ&h�FhN�5�CJOJQJ\�^JaJ h�Fh1K�CJOJQJ^JaJ h�Fh�fCJOJQJ^JaJ h�Fh�dhCJOJQJ^JaJ&h�FhlS�5�CJOJQJ\�^JaJ&h�FhQg5�CJOJQJ\�^JaJ h�Fh�3CJOJQJ^JaJ h�Fh�;�CJOJQJ^JaJ h�Fh�V`CJOJQJ^JaJ h�Fh�n�CJOJQJ^JaJ������[ghlm����������ɸ�����������l[F[)jh�Fh�XCJOJQJU^JaJ h�Fh�XCJOJQJ^JaJ)jh�Fh�B�CJOJQJU^JaJ h�Fh�CJOJQJ^JaJ h�Fh�#�CJOJQJ^JaJ)h�Fh�#�B*CJOJQJ^JaJph h�FhL
gCJOJQJ^JaJ#h�Fh)�5�CJOJQJ^JaJ&h�Fh�475�CJOJQJ\�^JaJ h�Fhi%CJOJQJ^JaJEFGHIJK�Һ��zizS8��' h�Fha CJOJQJ^JaJ4jh�Fh�"CJOJQJU^JaJmHnHu+h�Fh�cCJOJQJ^JaJmHnHu h�Fh�"CJOJQJ^JaJ)jh�Fh�"CJOJQJU^JaJ+h�Fh�XCJOJQJ^JaJmHnHu)jh�Fh�B�CJOJQJU^JaJ/�j�	h�Fh�B�CJOJQJU^JaJ)jh�Fh�XCJOJQJU^JaJ/�jh�Fh�XCJOJQJU^JaJ
Khijyz�����������ɸ����s�]H7H h�Fh�"CJOJQJ^JaJ)jh�Fh�"CJOJQJU^JaJ+h�Fh�XCJOJQJ^JaJmHnHu/�j^h�Fh�B�CJOJQJU^JaJ/�j�h�Fh�XCJOJQJU^JaJ)jh�Fh�XCJOJQJU^JaJ h�Fh�XCJOJQJ^JaJ)jh�Fh�B�CJOJQJU^JaJ h�Fh�#�CJOJQJ^JaJ h�FhL
gCJOJQJ^JaJ����������CDEFpqrstuv�θ���p��_��J9J�θ�p h�Fh�"CJOJQJ^JaJ)jh�Fh�"CJOJQJU^JaJ h�Fh�XCJOJQJ^JaJ h�FhL
gCJOJQJ^JaJ h�Fh�i�CJOJQJ^JaJ h�Fha CJOJQJ^JaJ)jh�Fh�B�CJOJQJU^JaJ+h�Fh�XCJOJQJ^JaJmHnHu4jh�Fh�"CJOJQJU^JaJmHnHu+h�Fh�cCJOJQJ^JaJmHnHuv|� !56789:��ɸɸ��}�e}M�7+h�Fh�XCJOJQJ^JaJmHnHu/�j�-h�Fh�#�CJOJQJU^JaJ/�j%h�Fh�XCJOJQJU^JaJ)jh�Fh�XCJOJQJU^JaJ h�Fh�XCJOJQJ^JaJ)jh�Fh�#�CJOJQJU^JaJ h�Fha CJOJQJ^JaJ h�Fh�#�CJOJQJ^JaJ$h�Fh�#�0JCJOJQJ^JaJ$h�Fh�>"0JCJOJQJ^JaJ:;jklmnop���������è�}jYHYHY7 h�Fh�>"CJOJQJ^JaJ h�Fha CJOJQJ^JaJ h�Fh�#�CJOJQJ^JaJ$h�Fh�|�0JCJOJQJ^JaJ)jh�Fh�#�CJOJQJU^JaJ+h�Fh�XCJOJQJ^JaJmHnHu4jh�Fh�"CJOJQJU^JaJmHnHu+h�Fh�cCJOJQJ^JaJmHnHu h�Fh�"CJOJQJ^JaJ)jh�Fh�"CJOJQJU^JaJ��123BCWXYZ[\]��˶���x�`�J5)jh�Fh�"CJOJQJU^JaJ+h�Fh�XCJOJQJ^JaJmHnHu/�j�Nh�Fh�>"CJOJQJU^JaJ/�j6h�Fh�XCJOJQJU^JaJ)jh�Fh�XCJOJQJU^JaJ h�Fh�XCJOJQJ^JaJ)jh�Fh�>"CJOJQJU^JaJ h�Fha CJOJQJ^JaJ h�Fh�>"CJOJQJ^JaJ#h�Fh�>"CJH*OJQJ^JaJ
]������������MP�����ĩ�~m���\m\m\K6)jh�Fh�#�CJOJQJU^JaJ h�Fha CJOJQJ^JaJ h�Fh�#�CJOJQJ^JaJ h�Fh�>"CJOJQJ^JaJ)jh�Fh�>"CJOJQJU^JaJ+h�Fh�XCJOJQJ^JaJmHnHu4jh�Fh�"CJOJQJU^JaJmHnHu+h�Fh�cCJOJQJ^JaJmHnHu)jh�Fh�"CJOJQJU^JaJ h�Fh�"CJOJQJ^JaJ��������������������ڪ�jYjC(�4jh�Fh�"CJOJQJU^JaJmHnHu+h�Fh�cCJOJQJ^JaJmHnHu h�Fh�"CJOJQJ^JaJ)jh�Fh�"CJOJQJU^JaJ+h�Fh�XCJOJQJ^JaJmHnHu)jh�Fh�#�CJOJQJU^JaJ/�j4ph�Fh�#�CJOJQJU^JaJ/�j�gh�Fh�XCJOJQJU^JaJ)jh�Fh�XCJOJQJU^JaJ h�Fh�XCJOJQJ^JaJ����
~��������     ��ͼ޼޼޼޼ޫ��p�Xp@�/�j�h�Fh�B�CJOJQJU^JaJ/�j�xh�Fh�XCJOJQJU^JaJ)jh�Fh�XCJOJQJU^JaJ h�Fh�XCJOJQJ^JaJ)jh�Fh�B�CJOJQJU^JaJ h�Fha CJOJQJ^JaJ h�Fh=ICJOJQJ^JaJ h�Fh�>"CJOJQJ^JaJ h�Fh�\=CJOJQJ^JaJ h�Fh�#�CJOJQJ^JaJ 	 
 8 9 : ; < = U \ e � � � � � � � ���ԭ��}l[l[lJlJl8#h�Fh�\=CJOJQJ\�^JaJ h�Fh)�CJOJQJ^JaJ h�Fh�fCJOJQJ^JaJ h�Fh�\=CJOJQJ^JaJ)jh�Fh�B�CJOJQJU^JaJ4jh�Fh�"CJOJQJU^JaJmHnHu+h�Fh�cCJOJQJ^JaJmHnHu h�Fh�"CJOJQJ^JaJ)jh�Fh�"CJOJQJU^JaJ+h�Fh�XCJOJQJ^JaJmHnHu� � !"!#!0!9!?!]!w!x!�!�!�!�!�!�!�!�!�!�!��ɷ��~m~m~m~\~mGmGm)jh�Fha CJOJQJU^JaJ h�Fh�XCJOJQJ^JaJ h�Fha CJOJQJ^JaJ h�Fh?�CJOJQJ^JaJ&h�FhlS�5�CJOJQJ\�^JaJ&h�Fhv?g5�CJOJQJ\�^JaJ#*h�Fh�\=CJOJQJ^JaJ#*h�Fh�|�CJOJQJ^JaJ#h�Fh�\=CJOJQJ\�^JaJ#h�Fh)�CJOJQJ\�^JaJ�#!9!�#�%:(+�.�1�1�6�9�9����������t�$d��a$gd�3�m$*$d�a$gd�l�m$$d����a$gd�)�$d��a$gd�B�m$$
�D%d���[$\$a$gd�B�m$$d��7$8$H$a$gd�3�m$$�E��Vd����^�E�`�Va$gd�)�$d��7$8$H$a$gd�B�m$�!�!�!�!�!�!�!"""""""3"6"7"�ҺҤ�~�hM��<+<+ h�Fh�XCJOJQJ^JaJ h�Fh?�CJOJQJ^JaJ4jh�Fh�"CJOJQJU^JaJmHnHu+h�Fh�cCJOJQJ^JaJmHnHu h�Fh�"CJOJQJ^JaJ)jh�Fh�"CJOJQJU^JaJ+h�Fha CJOJQJ^JaJmHnHu/�j��h�Fha CJOJQJU^JaJ)jh�Fha CJOJQJU^JaJ/�j�h�Fha CJOJQJU^JaJ7":"I"J"K"O"W"r"x"�"�"%$($)$0$�$�$
%�%''3'4'�'�'�'�'�'�����������|�umueuZSHSjh�Fh�XUh�Fh�Xjh�Fh�B�Uh�Fh?�H*h�Fh?�>*h�Fh?�:h�Fh�&�B*CJOJQJ^JaJfHphq�
���� h�Fh�&�CJOJQJ^JaJ h�Fha CJOJQJ^JaJ h�FhbZ�CJOJQJ^JaJ h�Fh�ICJOJQJ^JaJ h�Fh�XCJOJQJ^JaJ h�Fh?�CJOJQJ^JaJ�'((((((3(4(5(6(7(8(:(@(O(t)v)�)�)�)����������͋xeTBTeT#h�FhuT:CJH*OJQJ^JaJ h�FhuT:CJOJQJ^JaJ$h�FhuT:0JCJOJQJ^JaJ$h�Fht9�0JCJOJQJ^JaJh�Fh?� jh�Fh�"UmHnHuh�Fh�cmHnHuh�Fh�"jh�Fh�"Uh�Fh�XmHnHujh�Fh�B�U�j��h�Fh�B�Ujh�Fh�XU�jH�h�Fh�XU�)�)***�*�*�*�*�*�*�*�*�*�*�*�*�*��ɷɢɢɊ�r�\G6G h�Fh�"CJOJQJ^JaJ)jh�Fh�"CJOJQJU^JaJ+h�FhuT:CJOJQJ^JaJmHnHu/�jl�h�FhuT:CJOJQJU^JaJ/�j�h�FhuT:CJOJQJU^JaJ)jh�FhuT:CJOJQJU^JaJ#h�FhuT:CJH*OJQJ^JaJ h�FhuT:CJOJQJ^JaJ h�Fh�|LCJOJQJ^JaJ(h�FhuT:CJOJQJ^JaJnHtH�*�*�*�*++++�-�-�.�.�.�.�.�.�.�θ��~jYHY7Y7Y7Y h�FhB�CJOJQJ^JaJ h�Fh�|LCJOJQJ^JaJ h�Fh?�CJOJQJ^JaJ&h�FhuT:5�CJOJQJ\�^JaJ&h�Fh�I5�CJOJQJ\�^JaJ h�FhuT:CJOJQJ^JaJ)jh�FhuT:CJOJQJU^JaJ+h�FhuT:CJOJQJ^JaJmHnHu4jh�Fh�"CJOJQJU^JaJmHnHu+h�Fh�cCJOJQJ^JaJmHnHu�.
/C/D/d/e/p/q/�/�/�/�/�/�/e0g0�01$1'1�1�1��Ƶƞ��Ƶƞ��n�]�]�K#h�Fh�tj5�CJOJQJ^JaJ h�Fh�|qCJOJQJ^JaJ&h�Fh?�6�CJOJQJ]�^JaJ6jh�Fh�"0JB*CJOJQJU^JaJph�-h�Fh?�0JB*CJOJQJ^JaJph� h�Fh�"CJOJQJ^JaJ)jh�Fh�"CJOJQJU^JaJ h�Fh?�CJOJQJ^JaJ&h�Fh?�5�CJOJQJ\�^JaJ�1�1�1;2<2=2?2M2R2d2f2o2w2x2}2�2�2�2�2�2�23*3,3�3�3�3�3
44-4.4M4����ʹ�ʨʗʨ�ʆ�u�u�u�u�du�S�S� h�l�h!@�CJOJQJ^JaJ h�l�h�|LCJOJQJ^JaJ h�l�h�^�CJOJQJ^JaJ h�l�h�81CJOJQJ^JaJ h�l�h�n�CJOJQJ^JaJ h�l�hO�CJOJQJ^JaJ h�l�h�P�CJOJQJ^JaJ h�l�h�hCJOJQJ^JaJ h�l�h�CJOJQJ^JaJ&h�Fhy5�5�CJOJQJ\�^JaJ M4W4`4a4|4Z5�5�5�5�5�5�5�6�6�6�6�6�6�677!7"707��ͼ��������xgVgEgVg h�Fh!@�CJOJQJ^JaJ h�Fh�%+CJOJQJ^JaJ h�Fh�hCJOJQJ^JaJ h�Fh�CJOJQJ^JaJ h�l�h��CJOJQJ^JaJ h�l�h�,4CJOJQJ^JaJ h�l�h�0+CJOJQJ^JaJ h�l�hZ$&CJOJQJ^JaJ h�l�h!@�CJOJQJ^JaJ h�l�h�hCJOJQJ^JaJ h�l�h�n�CJOJQJ^JaJ0717@7C7L7N7y7�7�7�7�7�7�7�7�7�7�7�7�7�7�7�7�7�7��˺ܩ�������v�d����R�A h�Fh�T)CJOJQJ^JaJ#h�Fh�%+CJH*OJQJ^JaJ#h�Fh�~�CJH*OJQJ^JaJ h�Fh�P�CJOJQJ^JaJ h�Fh�%+CJOJQJ^JaJ h�Fh�~�CJOJQJ^JaJ h�Fh!@�CJOJQJ^JaJ h�Fh�c�CJOJQJ^JaJ h�Fh�|LCJOJQJ^JaJ h�Fh�hCJOJQJ^JaJ#h�Fh�hCJH*OJQJ^JaJ�78'8)8�8�8�8�8�8�8�8�8�8,9-91929=9{9}9�9�9�9���޼����ވ͈v���dRd@d#h�Fhm2CJOJQJ\�^JaJ#h�Fh�P�CJOJQJ\�^JaJ#h�Fh�h^CJOJQJ\�^JaJ#h�Fh�	�CJH*OJQJ^JaJ h�Fh�	�CJOJQJ^JaJ h�Fh��CJOJQJ^JaJ#h�Fh�CCJH*OJQJ^JaJ h�Fh�CCJOJQJ^JaJ h�Fh�P�CJOJQJ^JaJ h�Fh�T)CJOJQJ^JaJ h�Fh�WVCJOJQJ^JaJ�9�9�9�9�9[:_:�:�:�:�:�:�:�:�:�:�:�:�:�:�:�:�:���ݿ�����o�_�_o�o�Oh�Fh�8�CJOJQJ\�aJh�Fh�#CJOJQJ\�aJh�Fh�l�CJOJQJ\�aJh�Fh�L<CJOJQJ\�aJh�Fh�}�CJOJQJ\�aJh�Fh?�CJOJQJ\�aJh�Fh�E�CJOJQJ\�aJh�Fh�E�CJOJQJaJh�Fh�CJOJQJaJh�Fh?�CJOJQJaJ&h�Fhy5�5�CJOJQJ\�^JaJ�:�:�:T;r;t;{;�;�;�;�;�;�;�;�;�;�;�;<<<G<I<L<Q<���³���w����w��w�wdUd�Fh�Fh#B�CJOJQJaJh�Fh�"CJOJQJaJ%jh�Fh�"CJOJQJUaJh�Fh<
CJOJQJaJh�Fh�5�CJOJQJaJh�Fh�F�CJOJQJaJh�Fh?�CJOJQJaJh�Fh!�CJOJQJaJh�Fh�l�CJOJQJaJ-h�Fh�(PCJOJQJaJfHq�
����-h�Fh�l�CJOJQJaJfHq�
�����9L<�@�I�K(V�b�fՀ^�k�E�X�ۄ�������������$d��a$gd .5m$$d����7$8$H$a$gd�~�$
�D%d�a$gd�
�m$$d��7$8$H$a$gd .5m$$d��7$8$H$a$gd�B�m$$
�D%d�a$gd�tbm$$
�D%d�a$gd�3�m$
Q<G=H=I=X=Y=m=n=o=p=q=r=s=�=�=�=�=�=����񦼐�|iZiF-|0jh�Fh�"CJOJQJUaJmHnHu'h�Fh�cCJOJQJaJmHnHuh�Fh�"CJOJQJaJ%jh�Fh�"CJOJQJUaJ'h�Fh+Y�CJOJQJaJmHnHu+�j��h�Fh�B�CJOJQJUaJ+�j��h�Fh+Y�CJOJQJUaJ%jh�Fh+Y�CJOJQJUaJ%jh�Fh�B�CJOJQJUaJh�Fh��CJOJQJaJh�Fh+Y�CJOJQJaJ�=�=�=�=�=�=�=$>~>�>"?$?�?�?�?�?�?�?�?���ٻ�����paN�;�%jh�Fh�tbCJOJQJUaJ%jh�Fh�r�CJOJQJUaJh�Fh��CJOJQJaJh�Fh�q#CJOJQJaJh�Fh�{�CJOJQJaJh�Fh+Y�CJOJQJaJh�Fh�tbCJOJQJaJh�Fh�W�CJOJQJaJh�Fhm.�CJOJQJaJh�Fh�"CJOJQJaJ%jh�Fh�"CJOJQJUaJ%jh�Fh�B�CJOJQJUaJ�?�?�?�?�?�?�?(@)@+@,@.@/@b@c@e@f@g@h@i@�@�@�@�����w�cJ��w�cJ���w�;h�Fhm.�CJOJQJaJ0jh�Fh�"CJOJQJUaJmHnHu'h�Fh�cCJOJQJaJmHnHuh�Fh�"CJOJQJaJ%jh�Fh�"CJOJQJUaJ'h�Fh�tbCJOJQJaJmHnHu%jh�Fh�r�CJOJQJUaJ+�jf
h�Fh�r�CJOJQJUaJ%jh�Fh�tbCJOJQJUaJ+�j�h�Fh�tbCJOJQJUaJ�@�@�@�@�@�@�@�@*ASAmA�A�AIII I��Ͼ�����z�ezeO:)jh�Fh�"CJOJQJU^JaJ+h�Fh.U�CJOJQJ^JaJmHnHu)jh�Fh��CJOJQJU^JaJ h�Fh.U�CJOJQJ^JaJ h�Fh��CJOJQJ^JaJ h�Fh�{�CJOJQJ^JaJ h�Fhm.�CJOJQJ^JaJ h�Fh;I�CJOJQJ^JaJ h�Fh�cCJOJQJ^JaJ h�Fh�CJOJQJ^JaJh�Fh�CJOJQJaJ IQIRITIUIVIWIXIYIhIiI}I~II��ĩ�~mXGXG/X/�j�h�Fh.U�CJOJQJU^JaJ h�Fh.U�CJOJQJ^JaJ)jh�Fh.U�CJOJQJU^JaJ h�Fh��CJOJQJ^JaJ)jh�Fh��CJOJQJU^JaJ+h�Fh.U�CJOJQJ^JaJmHnHu4jh�Fh�"CJOJQJU^JaJmHnHu+h�Fh�cCJOJQJ^JaJmHnHu)jh�Fh�"CJOJQJU^JaJ h�Fh�"CJOJQJ^JaJ
I�I�I�I�I�I�I�I�I�I�I�I�I�IDJ�Ҽ����e��TC2C h�Fh�)�CJOJQJ^JaJ h�Fh�cCJOJQJ^JaJ h�Fh�{�CJOJQJ^JaJ4jh�Fh�"CJOJQJU^JaJmHnHu+h�Fh�cCJOJQJ^JaJmHnHu h�Fh�"CJOJQJ^JaJ)jh�Fh�"CJOJQJU^JaJ+h�Fh.U�CJOJQJ^JaJmHnHu)jh�Fh.U�CJOJQJU^JaJ/�j�$h�Fh.U�CJOJQJU^JaJDJEJTJUJiJjJkJlJmJnJoJ�J�J�J�J�J�J0K1K@KAKUKVK������~m~�R�������:/�j$Ah�Fh�cCJOJQJU^JaJ4jh�Fh�"CJOJQJU^JaJmHnHu h�Fh�"CJOJQJ^JaJ)jh�Fh�"CJOJQJU^JaJ+h�Fh�cCJOJQJ^JaJmHnHu/�j�7h�Fh�cCJOJQJU^JaJ/�j�.h�Fh�cCJOJQJU^JaJ h�Fh�cCJOJQJ^JaJ)jh�Fh�cCJOJQJU^JaJVKWKXKYKZK[K�K�K�K�K�K�K�K�K�K�K�K�K�K�K#L$L��꼧���{�����{��jYH7 h�Fh�LCJOJQJ^JaJ h�Fh�{�CJOJQJ^JaJ h�Fh�g�CJOJQJ^JaJ h�Fh�cCJOJQJ^JaJ4jh�Fh�"CJOJQJU^JaJmHnHu h�Fh�"CJOJQJ^JaJ)jh�Fh�"CJOJQJU^JaJ+h�Fh�cCJOJQJ^JaJmHnHu/�jRh�Fh�cCJOJQJU^JaJ)jh�Fh�cCJOJQJU^JaJ$LTLULVL�R�R�R�RSSS S!S"S.SuS��ɸɢ�|�fK��:) h�FhOECJOJQJ^JaJ h�Fh�LCJOJQJ^JaJ4jh�Fh�"CJOJQJU^JaJmHnHu+h�Fh�cCJOJQJ^JaJmHnHu h�Fh�"CJOJQJ^JaJ)jh�Fh�"CJOJQJU^JaJ+h�Fh�tbCJOJQJ^JaJmHnHu h�Fh�tbCJOJQJ^JaJ)jh�Fh�B�CJOJQJU^JaJ h�Fh�i�CJOJQJ^JaJ h�Fh�{�CJOJQJ^JaJuSvS�S�S�S�S�S�S�S�S�S�S�ST	TT��ɸ����s�]H7H] h�Fh�"CJOJQJ^JaJ)jh�Fh�"CJOJQJU^JaJ+h�Fh�cCJOJQJ^JaJmHnHu/�j�mh�Fh�B�CJOJQJU^JaJ/�jch�Fh�cCJOJQJU^JaJ)jh�Fh�cCJOJQJU^JaJ h�Fh�cCJOJQJ^JaJ)jh�Fh�B�CJOJQJU^JaJ h�FhOECJOJQJ^JaJ h�Fh�LCJOJQJ^JaJTT
TTTT T2T>T�TUUUU'U�Ϻ���ucuR�A,A)jh�Fh�cCJOJQJU^JaJ h�Fh�cCJOJQJ^JaJ h�Fh�g�CJOJQJ^JaJ#h�Fh<c3CJOJQJ\�^JaJ#h�Fh�g�CJOJQJ\�^JaJ h�Fh��CJOJQJ^JaJ h�Fh.U�CJOJQJ^JaJ h�FhOECJOJQJ^JaJ)jh�Fh�B�CJOJQJU^JaJ+h�Fh�cCJOJQJ^JaJmHnHu4jh�Fh�"CJOJQJU^JaJmHnHu'U(U)U*U+U,U-U]U^U`UaUbUcU�U�U�U�Һ��ziz�N��=,= h�FhADCJOJQJ^JaJ h�Fh��CJOJQJ^JaJ4jh�Fh�"CJOJQJU^JaJmHnHu h�Fh�"CJOJQJ^JaJ)jh�Fh�"CJOJQJU^JaJ+h�Fh�cCJOJQJ^JaJmHnHu)jh�Fh�B�CJOJQJU^JaJ/�jr�h�Fh�B�CJOJQJU^JaJ)jh�Fh�cCJOJQJU^JaJ/�jxxh�Fh�cCJOJQJU^JaJ�UV%V'V(V*V,V_VgV�V�V�V�V�V�VPW
XX��ͼ���h�h�O�O�>- h�FhZg=CJOJQJ^JaJ h�FhKCJOJQJ^JaJ1h�Fh�5�CJOJQJ^JaJfHq�
����1h�FhX!
CJOJQJ^JaJfHq�
����1h�Fhg?�CJOJQJ^JaJfHq�
���� h�Fh�)�CJOJQJ^JaJ h�Fh�`@CJOJQJ^JaJ h�Fh��CJOJQJ^JaJ h�Fh�0@CJOJQJ^JaJ h�Fh+Y�CJOJQJ^JaJ h�Fhm�CJOJQJ^JaJXXXX0X1X2X3X4X5X6XdXeXgXhXjXkX�X�X�X�X�X�X�X���٬Ĕ�~iXi~=~iXi~=~�i4jh�Fh�"CJOJQJU^JaJmHnHu h�Fh�"CJOJQJ^JaJ)jh�Fh�"CJOJQJU^JaJ+h�Fh�cCJOJQJ^JaJmHnHu/�j2�h�Fh�B�CJOJQJU^JaJ/�jl�h�Fh�cCJOJQJU^JaJ)jh�Fh�cCJOJQJU^JaJ h�Fh�cCJOJQJ^JaJ)jh�Fh�B�CJOJQJU^JaJ�X�X�XYY;Y=YHYOYZZ Z!Z5Z6Z7Z8Z9Z:Z;ZiZjZ������ɸɣ�}�e}M�7���+h�Fh�cCJOJQJ^JaJmHnHu/�j��h�Fh�B�CJOJQJU^JaJ/�j��h�Fh�cCJOJQJU^JaJ)jh�Fh�cCJOJQJU^JaJ h�Fh�cCJOJQJ^JaJ)jh�Fh�B�CJOJQJU^JaJ h�Fh�5�CJOJQJ^JaJ h�FhKCJOJQJ^JaJ)jh�Fh�"CJOJQJU^JaJ h�Fh�"CJOJQJ^JaJjZlZmZnZoZpZ�Z�Z�Z�Z�Z�Z�Z�Z�Z�Z�Z�Z�Z�Z��鹨���������u`uH`/�j��h�Fh�cCJOJQJU^JaJ)jh�Fh�cCJOJQJU^JaJ h�Fh�cCJOJQJ^JaJ h�Fh�r�CJOJQJ^JaJ h�Fh�5�CJOJQJ^JaJ h�FhKCJOJQJ^JaJ)jh�Fh�B�CJOJQJU^JaJ4jh�Fh�"CJOJQJU^JaJmHnHu+h�Fh�cCJOJQJ^JaJmHnHu�Z�Z�Z�Z�Z)[*[,[-[.[/[0[�[�[�[�b�b�b�b�b�b�b�Ҽ����{��jYH�7Ҽ���� h�Fh�cCJOJQJ^JaJ h�Fh�r�CJOJQJ^JaJ h�Fh�5�CJOJQJ^JaJ h�Fh�i�CJOJQJ^JaJ4jh�Fh�"CJOJQJU^JaJmHnHu h�Fh�"CJOJQJ^JaJ)jh�Fh�"CJOJQJU^JaJ+h�Fh�cCJOJQJ^JaJmHnHu)jh�Fh�B�CJOJQJU^JaJ/�j�h�Fh�B�CJOJQJU^JaJ�b�b�b�b�b�b�bcc&cZc�c�c�c�c�c�c�c�Ϻ���v�e�TA.A�v�$h�Fh(!MCJOJPJQJ^JaJ$h�Fh�b�CJOJPJQJ^JaJ h�Fh(!MCJOJQJ^JaJ h�Fh�5�CJOJQJ^JaJ h�Fh�`@CJOJQJ^JaJ h�Fh�b�CJOJQJ^JaJ h�Fh�)�CJOJQJ^JaJ h�Fh�r�CJOJQJ^JaJ)jh�Fh�B�CJOJQJU^JaJ+h�Fh�cCJOJQJ^JaJmHnHu4jh�Fh�"CJOJQJU^JaJmHnHu�cddd$d%d&d'd(d)d*dXdYdZd�վդ���r]L]4/h�Fh�cCJOJPJQJ^JaJmHnHu h�Fh�"CJOJQJ^JaJ)jh�Fh�"CJOJQJU^JaJ/h�Fh�XCJOJPJQJ^JaJmHnHu3�jv�h�Fh�B�CJOJPJQJU^JaJ3�j\�h�Fh�XCJOJPJQJU^JaJ-jh�Fh�XCJOJPJQJU^JaJ$h�Fh�XCJOJPJQJ^JaJ-jh�Fh�B�CJOJPJQJU^JaJ
Zd[d\d]d^d`didodpdxd�d�d�d�d�d�d�d9eAeOePe\eke�e�e�˴�����nn�nn]]�L h�Fh�i�CJOJQJ^JaJ h�Fh�!*CJOJQJ^JaJ h�Fh�b�CJOJQJ^JaJ h�Fh�5�CJOJQJ^JaJ h�Fh�`@CJOJQJ^JaJ$h�Fh�`@CJOJPJQJ^JaJ-jh�Fh�B�CJOJPJQJU^JaJ/h�Fh�XCJOJPJQJ^JaJmHnHu8jh�Fh�"CJOJPJQJU^JaJmHnHu�e�e�e�e�e�e�e�efff2f3f5f6f7f8f���٬Ĕ�~iXi~=~�4jh�Fh�"CJOJQJU^JaJmHnHu h�Fh�"CJOJQJ^JaJ)jh�Fh�"CJOJQJU^JaJ+h�Fh�cCJOJQJ^JaJmHnHu/�j�h�Fh�B�CJOJQJU^JaJ/�j��h�Fh�cCJOJQJU^JaJ)jh�Fh�cCJOJQJU^JaJ h�Fh�cCJOJQJ^JaJ)jh�Fh�B�CJOJQJU^JaJ8fYf]fcf�f�f�f�f�f�f�f�f(g)g8g9gMgNgOg��ͼ��vevPvPv8P/�j�h�Fh�cCJOJQJU^JaJ)jh�Fh�cCJOJQJU^JaJ h�Fh�\NCJOJQJ^JaJ h�Fh�cCJOJQJ^JaJ#h�Fh�h�5�CJOJQJ^JaJ#h�Fh�-C5�CJOJQJ^JaJ h�Fhr6$CJOJQJ^JaJ h�Fh�!*CJOJQJ^JaJ h�Fh�M}CJOJQJ^JaJ h�Fh�b�CJOJQJ^JaJ h�Fh�`@CJOJQJ^JaJOgPgQgRgSg�g�g�g�g�g�g�g�gcodoeofo�o�o�o�o�o�o�o�o�v�v�v�v�v�v�v�v�v�v�v�v�~�~�~�~
�Ҽ����{��j�jҼ����{��j�jҼ����{��j�jҼ�� h�Fh�cCJOJQJ^JaJ4jh�Fh�"CJOJQJU^JaJmHnHu h�Fh�"CJOJQJ^JaJ)jh�Fh�"CJOJQJU^JaJ+h�Fh�cCJOJQJ^JaJmHnHu)jh�Fh�cCJOJQJU^JaJ/�j�h�Fh�cCJOJQJU^JaJ)
��)�J�ԀՀۀl�o�v��ԹԤ��q�q`O>-� h�Fh�{�CJOJQJ^JaJ h�Fh?�CJOJQJ^JaJ h�Fh��CJOJQJ^JaJ h�Fh;GCJOJQJ^JaJ h�Fh�ECJOJQJ^JaJ h�Fh6�CJOJQJ^JaJ h�Fh�cCJOJQJ^JaJ)jh�Fh�cCJOJQJU^JaJ4jh�Fh�"CJOJQJU^JaJmHnHu+h�Fh�cCJOJQJ^JaJmHnHu)jh�Fh�"CJOJQJU^JaJv���������C�[�^�i�j�k�o�x�����������ͼ���scL31h�Fh
n�0JCJOJQJaJfHq�
����-h�Fh
n�CJOJQJaJfHq�
����h�Fh?�CJOJQJ\�aJh�Fh�h�CJOJQJ\�aJ h�Fh�h�CJOJQJ^JaJ&h�Fh?�5�CJOJQJ\�^JaJ&h�Fh�h�5�CJOJQJ\�^JaJ h�Fhw�CJOJQJ^JaJ h�Fh��CJOJQJ^JaJ h�Fh?�CJOJQJ^JaJ h�FhR!�CJOJQJ^JaJ��������΂Ђl�m�����E�W�ۄ����V�f�g��ʹʹ�����o^H5^H5%h�Fh�3�B*CJOJQJaJph�+h�Fh�3�5�B*CJOJQJ\�aJph� h�Fh�3�CJOJQJ^JaJ&h�Fh�3�5�CJOJQJ\�^JaJh�Fh
n�CJOJQJaJ%jh�FhvelCJOJQJUaJh�FhvelCJOJQJaJ1h�Fh
n�0JCJOJQJaJfHq�
����1h�Fh�)�0JCJOJQJaJfHq�
����1h�Fhvel0JCJOJQJaJfHq�
����ۄ��V�g���������C����N��s�Z����������������(
�v���d��^�`��gd�Fm$$$d��a$gd .5m$$$d��a$gd�3�m$$d���-D9DM�
����[$\$a$gd�~�m$$d��a$gd .5m$d���-D9DM�
����gd�~�g�������������(�̆���q�������-�[�Ո������������$�>�@�e�Ȋ݊�	����ʹ����p�^�p�^�p�p�^�p�^�p�^�p�^�#h�Fh�c5�CJOJQJ^JaJ#h�Fh�c6�CJOJQJ^JaJ h�Fh�cCJOJQJ^JaJ h�Fh��CJOJQJ^JaJ)jh�Fh��CJOJQJU^JaJ h�Fh�x$CJOJQJ^JaJ&h�Fh�x$5�CJOJQJ\�^JaJ&h�Fh�3�5�CJOJQJ\�^JaJh�Fh .5h�Fh�3�$	�K�_�a���"�H�J�t���Ȍˌ�6�E�G�o����H�������؎Z�s�u�������D�ϐ��(�C�Z�[���Ñӑ֑�l�������'�;�>�N�O�P�f�œޓ��I�b�d���Ɣהٔ��.�=�@�s����������������������������������������������������ܼ������������������hmkh�chmkCJOJQJ^JaJ#h�Fh�c5�CJOJQJ^JaJ h�Fh�cCJOJQJ^JaJ#h�Fh�c6�CJOJQJ^JaJGZ�یW�+�Ŏ��*���k����O�P��t��Y����6��|����������������������$
�v���d��^�`��a$gd�Fm$$a$gdmk(
�v���d��^�`��gd�Fm$s���͖ϖ��s��������%�'�k���ИӘi�k�z�{�|�}���������������������������������������������������ܵ����������������}neh�l�mHnHujh�l�UmHnHu�*hwF�mHnHu�*jh�l�Uh�
�h�l�hr1�jhr1�U h�Fh�8CJOJQJ^JaJ)jh�Fh��CJOJQJU^JaJ#h�Fh�c5�CJOJQJ^JaJ h�Fh�cCJOJQJ^JaJ#h�Fh�c6�CJOJQJ^JaJ&|�~����������������������������������������������������$
�v���d��^�`��a$gd�Fm$gd�l�$a$	d��gdlS��������������������������������������� h�Fh�8CJOJQJ^JaJh�"h�
�hr1�h�l�h�
�mHnHuB	0
0090&P	1�h:p�l���. ��A!��"��#��$��%�������9
0&P	1�h:p�
���. ��A!��"�T#��$��%��������	D<EndNote><Cite><Author>Farhat</Author><Year>2006</Year><RecNum>1</RecNum><DisplayText>[1]</DisplayText><record><rec-number>1</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">1</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Farhat, G. N.</author><author>Strotmeyer, E. S.</author><author>Newman, A. B.</author><author>Sutton-Tyrrell, K.</author><author>Bauer, D. C.</author><author>Harris, T.</author><author>Johnson, K. C.</author><author>Taaffe, D. R.</author><author>Cauley, J. A.</author></authors></contributors><auth-address>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, 127 Parran Hall, PA 15261, USA. farhatg@edc.pitt.edu</auth-address><titles><title>Volumetric and areal bone mineral density measures are associated with cardiovascular disease in older men and women: the health, aging, and body composition study</title><secondary-title>Calcif Tissue Int</secondary-title><alt-title>Calcified tissue international</alt-title></titles><periodical><full-title>Calcif Tissue Int</full-title><abbr-1>Calcified tissue international</abbr-1></periodical><alt-periodical><full-title>Calcif Tissue Int</full-title><abbr-1>Calcified tissue international</abbr-1></alt-periodical><pages>102-11</pages><volume>79</volume><number>2</number><edition>2006/08/24</edition><keywords><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>*Aging</keyword><keyword>*Bone Density</keyword><keyword>Bone and Bones/*pathology</keyword><keyword>Cardiovascular Diseases/*complications/*etiology</keyword><keyword>Cytokines/metabolism</keyword><keyword>Female</keyword><keyword>Fractures, Bone/pathology/prevention &amp; control</keyword><keyword>Humans</keyword><keyword>Inflammation</keyword><keyword>Male</keyword><keyword>Regression Analysis</keyword><keyword>Risk Factors</keyword><keyword>Sex Factors</keyword></keywords><dates><year>2006</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>0171-967X (Print)&#xD;0171-967X (Linking)</isbn><accession-num>16927045</accession-num><work-type>Research Support, N.I.H., Extramural&#xD;Research Support, N.I.H., Intramural</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/16927045</url></related-urls></urls><electronic-resource-num>10.1007/s00223-006-0052-0</electronic-resource-num><language>eng</language></record></Cite></EndNote>�	D<EndNote><Cite><Author>Farhat</Author><Year>2006</Year><RecNum>1</RecNum><DisplayText>[1]</DisplayText><record><rec-number>1</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">1</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Farhat, G. N.</author><author>Strotmeyer, E. S.</author><author>Newman, A. B.</author><author>Sutton-Tyrrell, K.</author><author>Bauer, D. C.</author><author>Harris, T.</author><author>Johnson, K. C.</author><author>Taaffe, D. R.</author><author>Cauley, J. A.</author></authors></contributors><auth-address>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, 127 Parran Hall, PA 15261, USA. farhatg@edc.pitt.edu</auth-address><titles><title>Volumetric and areal bone mineral density measures are associated with cardiovascular disease in older men and women: the health, aging, and body composition study</title><secondary-title>Calcif Tissue Int</secondary-title><alt-title>Calcified tissue international</alt-title></titles><periodical><full-title>Calcif Tissue Int</full-title><abbr-1>Calcified tissue international</abbr-1></periodical><alt-periodical><full-title>Calcif Tissue Int</full-title><abbr-1>Calcified tissue international</abbr-1></alt-periodical><pages>102-11</pages><volume>79</volume><number>2</number><edition>2006/08/24</edition><keywords><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>*Aging</keyword><keyword>*Bone Density</keyword><keyword>Bone and Bones/*pathology</keyword><keyword>Cardiovascular Diseases/*complications/*etiology</keyword><keyword>Cytokines/metabolism</keyword><keyword>Female</keyword><keyword>Fractures, Bone/pathology/prevention &amp; control</keyword><keyword>Humans</keyword><keyword>Inflammation</keyword><keyword>Male</keyword><keyword>Regression Analysis</keyword><keyword>Risk Factors</keyword><keyword>Sex Factors</keyword></keywords><dates><year>2006</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>0171-967X (Print)&#xD;0171-967X (Linking)</isbn><accession-num>16927045</accession-num><work-type>Research Support, N.I.H., Extramural&#xD;Research Support, N.I.H., Intramural</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/16927045</url></related-urls></urls><electronic-resource-num>10.1007/s00223-006-0052-0</electronic-resource-num><language>eng</language></record></Cite></EndNote>�D<EndNote><Cite><Author>Alexandersen</Author><Year>2006</Year><RecNum>3</RecNum><DisplayText>[2]</DisplayText><record><rec-number>3</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">3</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Alexandersen, P.</author><author>Tanko, L. B.</author><author>Bagger, Y. Z.</author><author>Jespersen, J.</author><author>Skouby, S. O.</author><author>Christiansen, C.</author></authors></contributors><auth-address>Center for Clinical and Basic Research A/S, Ballerup Byvej 222, DK-2750 Ballerup, Denmark. pa@ccbr.dk</auth-address><titles><title>Associations between aortic calcification and components of body composition in elderly men</title><secondary-title>Obesity (Silver Spring)</secondary-title></titles><periodical><full-title>Obesity (Silver Spring)</full-title></periodical><pages>1571-8</pages><volume>14</volume><number>9</number><edition>2006/10/13</edition><keywords><keyword>Absorptiometry, Photon</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Aging/blood/*pathology</keyword><keyword>Aortic Diseases/blood/etiology/*pathology</keyword><keyword>Atherosclerosis/blood/epidemiology/pathology</keyword><keyword>Body Composition/*physiology</keyword><keyword>Calcinosis/complications/*pathology/radiography</keyword><keyword>Cardiovascular Diseases/blood/epidemiology/pathology</keyword><keyword>Cholesterol/*blood</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Multivariate Analysis</keyword><keyword>Obesity/complications/pathology</keyword><keyword>Risk Factors</keyword><keyword>Severity of Illness Index</keyword></keywords><dates><year>2006</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>1930-7381 (Print)&#xD;1930-7381 (Linking)</isbn><accession-num>17030968</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/17030968</url></related-urls></urls><electronic-resource-num>10.1038/oby.2006.181</electronic-resource-num><language>eng</language></record></Cite></EndNote>�D<EndNote><Cite><Author>Alexandersen</Author><Year>2006</Year><RecNum>3</RecNum><DisplayText>[2]</DisplayText><record><rec-number>3</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">3</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Alexandersen, P.</author><author>Tanko, L. B.</author><author>Bagger, Y. Z.</author><author>Jespersen, J.</author><author>Skouby, S. O.</author><author>Christiansen, C.</author></authors></contributors><auth-address>Center for Clinical and Basic Research A/S, Ballerup Byvej 222, DK-2750 Ballerup, Denmark. pa@ccbr.dk</auth-address><titles><title>Associations between aortic calcification and components of body composition in elderly men</title><secondary-title>Obesity (Silver Spring)</secondary-title></titles><periodical><full-title>Obesity (Silver Spring)</full-title></periodical><pages>1571-8</pages><volume>14</volume><number>9</number><edition>2006/10/13</edition><keywords><keyword>Absorptiometry, Photon</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Aging/blood/*pathology</keyword><keyword>Aortic Diseases/blood/etiology/*pathology</keyword><keyword>Atherosclerosis/blood/epidemiology/pathology</keyword><keyword>Body Composition/*physiology</keyword><keyword>Calcinosis/complications/*pathology/radiography</keyword><keyword>Cardiovascular Diseases/blood/epidemiology/pathology</keyword><keyword>Cholesterol/*blood</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Multivariate Analysis</keyword><keyword>Obesity/complications/pathology</keyword><keyword>Risk Factors</keyword><keyword>Severity of Illness Index</keyword></keywords><dates><year>2006</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>1930-7381 (Print)&#xD;1930-7381 (Linking)</isbn><accession-num>17030968</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/17030968</url></related-urls></urls><electronic-resource-num>10.1038/oby.2006.181</electronic-resource-num><language>eng</language></record></Cite></EndNote>�D<EndNote><Cite><Author>Lenchik</Author><Year>2004</Year><RecNum>6</RecNum><DisplayText>[4]</DisplayText><record><rec-number>6</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">6</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lenchik, L.</author><author>Shi, R.</author><author>Register, T. C.</author><author>Beck, S. R.</author><author>Langefeld, C. D.</author><author>Carr, J. J.</author></authors></contributors><auth-address>Department of Radiology, Wake Forest University School of Medicine, University Health Sciences, Winston-Salem, NC 27157, USA. llenchik@wfubmc.edu</auth-address><titles><title>Measurement of trabecular bone mineral density in the thoracic spine using cardiac gated quantitative computed tomography</title><secondary-title>J Comput Assist Tomogr</secondary-title><alt-title>Journal of computer assisted tomography</alt-title></titles><periodical><full-title>J Comput Assist Tomogr</full-title><abbr-1>Journal of computer assisted tomography</abbr-1></periodical><alt-periodical><full-title>J Comput Assist Tomogr</full-title><abbr-1>Journal of computer assisted tomography</abbr-1></alt-periodical><pages>134-9</pages><volume>28</volume><number>1</number><edition>2004/01/13</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>*Bone Density</keyword><keyword>Female</keyword><keyword>Heart/radiography</keyword><keyword>Humans</keyword><keyword>Lumbar Vertebrae/radiography</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Radiography, Abdominal</keyword><keyword>Reproducibility of Results</keyword><keyword>Thoracic Vertebrae/*radiography</keyword><keyword>*Tomography, X-Ray Computed/methods</keyword></keywords><dates><year>2004</year><pub-dates><date>Jan-Feb</date></pub-dates></dates><isbn>0363-8715 (Print)&#xD;0363-8715 (Linking)</isbn><accession-num>14716247</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/14716247</url></related-urls></urls><language>eng</language></record></Cite></EndNote>�D<EndNote><Cite><Author>Lenchik</Author><Year>2004</Year><RecNum>6</RecNum><DisplayText>[4]</DisplayText><record><rec-number>6</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">6</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lenchik, L.</author><author>Shi, R.</author><author>Register, T. C.</author><author>Beck, S. R.</author><author>Langefeld, C. D.</author><author>Carr, J. J.</author></authors></contributors><auth-address>Department of Radiology, Wake Forest University School of Medicine, University Health Sciences, Winston-Salem, NC 27157, USA. llenchik@wfubmc.edu</auth-address><titles><title>Measurement of trabecular bone mineral density in the thoracic spine using cardiac gated quantitative computed tomography</title><secondary-title>J Comput Assist Tomogr</secondary-title><alt-title>Journal of computer assisted tomography</alt-title></titles><periodical><full-title>J Comput Assist Tomogr</full-title><abbr-1>Journal of computer assisted tomography</abbr-1></periodical><alt-periodical><full-title>J Comput Assist Tomogr</full-title><abbr-1>Journal of computer assisted tomography</abbr-1></alt-periodical><pages>134-9</pages><volume>28</volume><number>1</number><edition>2004/01/13</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>*Bone Density</keyword><keyword>Female</keyword><keyword>Heart/radiography</keyword><keyword>Humans</keyword><keyword>Lumbar Vertebrae/radiography</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Radiography, Abdominal</keyword><keyword>Reproducibility of Results</keyword><keyword>Thoracic Vertebrae/*radiography</keyword><keyword>*Tomography, X-Ray Computed/methods</keyword></keywords><dates><year>2004</year><pub-dates><date>Jan-Feb</date></pub-dates></dates><isbn>0363-8715 (Print)&#xD;0363-8715 (Linking)</isbn><accession-num>14716247</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/14716247</url></related-urls></urls><language>eng</language></record></Cite></EndNote>�D<EndNote><Cite><Author>Budoff</Author><Year>2012</Year><RecNum>7</RecNum><DisplayText>[4-6]</DisplayText><record><rec-number>7</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">7</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Budoff, M. J.</author><author>Khairallah, W.</author><author>Li, D.</author><author>Gao, Y. L.</author><author>Ismaeel, H.</author><author>Flores, F.</author><author>Child, J.</author><author>Carson, S.</author><author>Mao, S. S.</author></authors></contributors><auth-address>Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA 90502, USA. mbudoff@labiomed.org</auth-address><titles><title>Trabecular bone mineral density measurement using thoracic and lumbar quantitative computed tomography</title><secondary-title>Acad Radiol</secondary-title><alt-title>Academic radiology</alt-title></titles><periodical><full-title>Acad Radiol</full-title><abbr-1>Academic radiology</abbr-1></periodical><alt-periodical><full-title>Acad Radiol</full-title><abbr-1>Academic radiology</abbr-1></alt-periodical><pages>179-83</pages><volume>19</volume><number>2</number><keywords><keyword>Analysis of Variance</keyword><keyword>*Bone Density</keyword><keyword>Cardiac-Gated Imaging Techniques</keyword><keyword>Coronary Artery Disease/*radiography</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Lumbar Vertebrae/*radiography</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Osteoporosis/*radiography</keyword><keyword>Phantoms, Imaging</keyword><keyword>Reproducibility of Results</keyword><keyword>Sex Factors</keyword><keyword>Thoracic Vertebrae/*radiography</keyword><keyword>Tomography, X-Ray Computed/*methods</keyword></keywords><dates><year>2012</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1878-4046 (Electronic)&#xD;1076-6332 (Linking)</isbn><accession-num>22112461</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/22112461</url></related-urls></urls><electronic-resource-num>10.1016/j.acra.2011.10.006</electronic-resource-num></record></Cite><Cite><Author>Lenchik</Author><Year>2004</Year><RecNum>6</RecNum><record><rec-number>6</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">6</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lenchik, L.</author><author>Shi, R.</author><author>Register, T. C.</author><author>Beck, S. R.</author><author>Langefeld, C. D.</author><author>Carr, J. J.</author></authors></contributors><auth-address>Department of Radiology, Wake Forest University School of Medicine, University Health Sciences, Winston-Salem, NC 27157, USA. llenchik@wfubmc.edu</auth-address><titles><title>Measurement of trabecular bone mineral density in the thoracic spine using cardiac gated quantitative computed tomography</title><secondary-title>J Comput Assist Tomogr</secondary-title><alt-title>Journal of computer assisted tomography</alt-title></titles><periodical><full-title>J Comput Assist Tomogr</full-title><abbr-1>Journal of computer assisted tomography</abbr-1></periodical><alt-periodical><full-title>J Comput Assist Tomogr</full-title><abbr-1>Journal of computer assisted tomography</abbr-1></alt-periodical><pages>134-9</pages><volume>28</volume><number>1</number><edition>2004/01/13</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>*Bone Density</keyword><keyword>Female</keyword><keyword>Heart/radiography</keyword><keyword>Humans</keyword><keyword>Lumbar Vertebrae/radiography</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Radiography, Abdominal</keyword><keyword>Reproducibility of Results</keyword><keyword>Thoracic Vertebrae/*radiography</keyword><keyword>*Tomography, X-Ray Computed/methods</keyword></keywords><dates><year>2004</year><pub-dates><date>Jan-Feb</date></pub-dates></dates><isbn>0363-8715 (Print)&#xD;0363-8715 (Linking)</isbn><accession-num>14716247</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/14716247</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Wong</Author><Year>2005</Year><RecNum>80</RecNum><record><rec-number>80</rec-number><foreign-keys><key app="EN" db-id="adf9905v9zerxjezpdava52t0x55w52r0rdv">80</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wong, M.</author><author>Papa, A.</author><author>Lang, T.</author><author>Hodis, H. N.</author><author>Labree, L.</author><author>Detrano, R.</author></authors></contributors><auth-address>Division of Cardiology, Los Angeles Biomedical Research Instittute at Harbor-UCLA Medical Center, Torrance, California, USA.</auth-address><titles><title>Validation of thoracic quantitative computed tomography as a method to measure bone mineral density</title><secondary-title>Calcif Tissue Int</secondary-title><alt-title>Calcified tissue international</alt-title></titles><periodical><full-title>Calcif Tissue Int</full-title><abbr-1>Calcified tissue international</abbr-1></periodical><alt-periodical><full-title>Calcif Tissue Int</full-title><abbr-1>Calcified tissue international</abbr-1></alt-periodical><pages>7-10</pages><volume>76</volume><number>1</number><keywords><keyword>*Bone Density</keyword><keyword>California/epidemiology</keyword><keyword>Ethnic Groups</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Lumbar Vertebrae/metabolism/radiography</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Osteoporosis/diagnosis/ethnology</keyword><keyword>*Radiography, Thoracic</keyword><keyword>Reproducibility of Results</keyword><keyword>Thoracic Vertebrae/metabolism/radiography</keyword><keyword>Tomography, X-Ray Computed/*methods</keyword></keywords><dates><year>2005</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>0171-967X (Print)&#xD;0171-967X (Linking)</isbn><accession-num>15455185</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/15455185</url></related-urls></urls><electronic-resource-num>10.1007/s00223-004-0020-5</electronic-resource-num></record></Cite></EndNote>�D<EndNote><Cite><Author>Budoff</Author><Year>2012</Year><RecNum>7</RecNum><DisplayText>[4-6]</DisplayText><record><rec-number>7</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">7</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Budoff, M. J.</author><author>Khairallah, W.</author><author>Li, D.</author><author>Gao, Y. L.</author><author>Ismaeel, H.</author><author>Flores, F.</author><author>Child, J.</author><author>Carson, S.</author><author>Mao, S. S.</author></authors></contributors><auth-address>Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA 90502, USA. mbudoff@labiomed.org</auth-address><titles><title>Trabecular bone mineral density measurement using thoracic and lumbar quantitative computed tomography</title><secondary-title>Acad Radiol</secondary-title><alt-title>Academic radiology</alt-title></titles><periodical><full-title>Acad Radiol</full-title><abbr-1>Academic radiology</abbr-1></periodical><alt-periodical><full-title>Acad Radiol</full-title><abbr-1>Academic radiology</abbr-1></alt-periodical><pages>179-83</pages><volume>19</volume><number>2</number><keywords><keyword>Analysis of Variance</keyword><keyword>*Bone Density</keyword><keyword>Cardiac-Gated Imaging Techniques</keyword><keyword>Coronary Artery Disease/*radiography</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Lumbar Vertebrae/*radiography</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Osteoporosis/*radiography</keyword><keyword>Phantoms, Imaging</keyword><keyword>Reproducibility of Results</keyword><keyword>Sex Factors</keyword><keyword>Thoracic Vertebrae/*radiography</keyword><keyword>Tomography, X-Ray Computed/*methods</keyword></keywords><dates><year>2012</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1878-4046 (Electronic)&#xD;1076-6332 (Linking)</isbn><accession-num>22112461</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/22112461</url></related-urls></urls><electronic-resource-num>10.1016/j.acra.2011.10.006</electronic-resource-num></record></Cite><Cite><Author>Lenchik</Author><Year>2004</Year><RecNum>6</RecNum><record><rec-number>6</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">6</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lenchik, L.</author><author>Shi, R.</author><author>Register, T. C.</author><author>Beck, S. R.</author><author>Langefeld, C. D.</author><author>Carr, J. J.</author></authors></contributors><auth-address>Department of Radiology, Wake Forest University School of Medicine, University Health Sciences, Winston-Salem, NC 27157, USA. llenchik@wfubmc.edu</auth-address><titles><title>Measurement of trabecular bone mineral density in the thoracic spine using cardiac gated quantitative computed tomography</title><secondary-title>J Comput Assist Tomogr</secondary-title><alt-title>Journal of computer assisted tomography</alt-title></titles><periodical><full-title>J Comput Assist Tomogr</full-title><abbr-1>Journal of computer assisted tomography</abbr-1></periodical><alt-periodical><full-title>J Comput Assist Tomogr</full-title><abbr-1>Journal of computer assisted tomography</abbr-1></alt-periodical><pages>134-9</pages><volume>28</volume><number>1</number><edition>2004/01/13</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>*Bone Density</keyword><keyword>Female</keyword><keyword>Heart/radiography</keyword><keyword>Humans</keyword><keyword>Lumbar Vertebrae/radiography</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Radiography, Abdominal</keyword><keyword>Reproducibility of Results</keyword><keyword>Thoracic Vertebrae/*radiography</keyword><keyword>*Tomography, X-Ray Computed/methods</keyword></keywords><dates><year>2004</year><pub-dates><date>Jan-Feb</date></pub-dates></dates><isbn>0363-8715 (Print)&#xD;0363-8715 (Linking)</isbn><accession-num>14716247</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/14716247</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Wong</Author><Year>2005</Year><RecNum>80</RecNum><record><rec-number>80</rec-number><foreign-keys><key app="EN" db-id="adf9905v9zerxjezpdava52t0x55w52r0rdv">80</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wong, M.</author><author>Papa, A.</author><author>Lang, T.</author><author>Hodis, H. N.</author><author>Labree, L.</author><author>Detrano, R.</author></authors></contributors><auth-address>Division of Cardiology, Los Angeles Biomedical Research Instittute at Harbor-UCLA Medical Center, Torrance, California, USA.</auth-address><titles><title>Validation of thoracic quantitative computed tomography as a method to measure bone mineral density</title><secondary-title>Calcif Tissue Int</secondary-title><alt-title>Calcified tissue international</alt-title></titles><periodical><full-title>Calcif Tissue Int</full-title><abbr-1>Calcified tissue international</abbr-1></periodical><alt-periodical><full-title>Calcif Tissue Int</full-title><abbr-1>Calcified tissue international</abbr-1></alt-periodical><pages>7-10</pages><volume>76</volume><number>1</number><keywords><keyword>*Bone Density</keyword><keyword>California/epidemiology</keyword><keyword>Ethnic Groups</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Lumbar Vertebrae/metabolism/radiography</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Osteoporosis/diagnosis/ethnology</keyword><keyword>*Radiography, Thoracic</keyword><keyword>Reproducibility of Results</keyword><keyword>Thoracic Vertebrae/metabolism/radiography</keyword><keyword>Tomography, X-Ray Computed/*methods</keyword></keywords><dates><year>2005</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>0171-967X (Print)&#xD;0171-967X (Linking)</isbn><accession-num>15455185</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/15455185</url></related-urls></urls><electronic-resource-num>10.1007/s00223-004-0020-5</electronic-resource-num></record></Cite></EndNote>�D<EndNote><Cite><Author>Budoff</Author><Year>2012</Year><RecNum>7</RecNum><DisplayText>[5]</DisplayText><record><rec-number>7</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">7</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Budoff, M. J.</author><author>Khairallah, W.</author><author>Li, D.</author><author>Gao, Y. L.</author><author>Ismaeel, H.</author><author>Flores, F.</author><author>Child, J.</author><author>Carson, S.</author><author>Mao, S. S.</author></authors></contributors><auth-address>Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA 90502, USA. mbudoff@labiomed.org</auth-address><titles><title>Trabecular bone mineral density measurement using thoracic and lumbar quantitative computed tomography</title><secondary-title>Acad Radiol</secondary-title><alt-title>Academic radiology</alt-title></titles><periodical><full-title>Acad Radiol</full-title><abbr-1>Academic radiology</abbr-1></periodical><alt-periodical><full-title>Acad Radiol</full-title><abbr-1>Academic radiology</abbr-1></alt-periodical><pages>179-83</pages><volume>19</volume><number>2</number><keywords><keyword>Analysis of Variance</keyword><keyword>*Bone Density</keyword><keyword>Cardiac-Gated Imaging Techniques</keyword><keyword>Coronary Artery Disease/*radiography</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Lumbar Vertebrae/*radiography</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Osteoporosis/*radiography</keyword><keyword>Phantoms, Imaging</keyword><keyword>Reproducibility of Results</keyword><keyword>Sex Factors</keyword><keyword>Thoracic Vertebrae/*radiography</keyword><keyword>Tomography, X-Ray Computed/*methods</keyword></keywords><dates><year>2012</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1878-4046 (Electronic)&#xD;1076-6332 (Linking)</isbn><accession-num>22112461</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/22112461</url></related-urls></urls><electronic-resource-num>10.1016/j.acra.2011.10.006</electronic-resource-num></record></Cite></EndNote>�D<EndNote><Cite><Author>Budoff</Author><Year>2012</Year><RecNum>7</RecNum><DisplayText>[5]</DisplayText><record><rec-number>7</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">7</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Budoff, M. J.</author><author>Khairallah, W.</author><author>Li, D.</author><author>Gao, Y. L.</author><author>Ismaeel, H.</author><author>Flores, F.</author><author>Child, J.</author><author>Carson, S.</author><author>Mao, S. S.</author></authors></contributors><auth-address>Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA 90502, USA. mbudoff@labiomed.org</auth-address><titles><title>Trabecular bone mineral density measurement using thoracic and lumbar quantitative computed tomography</title><secondary-title>Acad Radiol</secondary-title><alt-title>Academic radiology</alt-title></titles><periodical><full-title>Acad Radiol</full-title><abbr-1>Academic radiology</abbr-1></periodical><alt-periodical><full-title>Acad Radiol</full-title><abbr-1>Academic radiology</abbr-1></alt-periodical><pages>179-83</pages><volume>19</volume><number>2</number><keywords><keyword>Analysis of Variance</keyword><keyword>*Bone Density</keyword><keyword>Cardiac-Gated Imaging Techniques</keyword><keyword>Coronary Artery Disease/*radiography</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Lumbar Vertebrae/*radiography</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Osteoporosis/*radiography</keyword><keyword>Phantoms, Imaging</keyword><keyword>Reproducibility of Results</keyword><keyword>Sex Factors</keyword><keyword>Thoracic Vertebrae/*radiography</keyword><keyword>Tomography, X-Ray Computed/*methods</keyword></keywords><dates><year>2012</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1878-4046 (Electronic)&#xD;1076-6332 (Linking)</isbn><accession-num>22112461</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/22112461</url></related-urls></urls><electronic-resource-num>10.1016/j.acra.2011.10.006</electronic-resource-num></record></Cite></EndNote>D<EndNote><Cite><Author>Ahmadi</Author><Year>2010</Year><RecNum>9</RecNum><DisplayText>[7]</DisplayText><record><rec-number>9</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">9</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ahmadi, N.</author><author>Tsimikas, S.</author><author>Hajsadeghi, F.</author><author>Saeed, A.</author><author>Nabavi, V.</author><author>Bevinal, M. A.</author><author>Kadakia, J.</author><author>Flores, F.</author><author>Ebrahimi, R.</author><author>Budoff, M. J.</author></authors></contributors><auth-address>Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, California, USA.</auth-address><titles><title>Relation of oxidative biomarkers, vascular dysfunction, and progression of coronary artery calcium</title><secondary-title>Am J Cardiol</secondary-title><alt-title>The American journal of cardiology</alt-title></titles><periodical><full-title>Am J Cardiol</full-title><abbr-1>The American journal of cardiology</abbr-1></periodical><alt-periodical><full-title>Am J Cardiol</full-title><abbr-1>The American journal of cardiology</abbr-1></alt-periodical><pages>459-66</pages><volume>105</volume><number>4</number><edition>2010/02/16</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Apolipoprotein B-100/blood</keyword><keyword>Autoantibodies/blood</keyword><keyword>Biological Markers/*blood</keyword><keyword>Calcinosis/*blood/drug therapy/*physiopathology/radiography</keyword><keyword>Calcium/blood</keyword><keyword>Coronary Artery Disease/*blood/drug therapy/*physiopathology/radiography</keyword><keyword>Dietary Supplements</keyword><keyword>Disease Progression</k	

 !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXZ����[\]^_`abcdefghijklmnopqrstuvwxyz{|}~�eyword><keyword>Double-Blind Method</keyword><keyword>Equipment Design</keyword><keyword>Female</keyword><keyword>Fingers/*blood supply</keyword><keyword>Follow-Up Studies</keyword><keyword>*Garlic</keyword><keyword>Humans</keyword><keyword>Immunoglobulin G/blood</keyword><keyword>Immunoglobulin M/blood</keyword><keyword>Lipoprotein(a)/blood</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Oxidative Stress/drug effects</keyword><keyword>Phospholipids/blood</keyword><keyword>Phytotherapy</keyword><keyword>Plant Extracts/therapeutic use</keyword><keyword>Predictive Value of Tests</keyword><keyword>Severity of Illness Index</keyword><keyword>*Skin Temperature</keyword><keyword>Thermography/methods</keyword><keyword>Treatment Outcome</keyword><keyword>Vitamin B Complex/therapeutic use</keyword></keywords><dates><year>2010</year><pub-dates><date>Feb 15</date></pub-dates></dates><isbn>1879-1913 (Electronic)&#xD;0002-9149 (Linking)</isbn><accession-num>20152239</accession-num><work-type>Randomized Controlled Trial</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/20152239</url></related-urls></urls><electronic-resource-num>10.1016/j.amjcard.2009.09.052</electronic-resource-num><language>eng</language></record></Cite></EndNote>D<EndNote><Cite><Author>Ahmadi</Author><Year>2010</Year><RecNum>9</RecNum><DisplayText>[7]</DisplayText><record><rec-number>9</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">9</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ahmadi, N.</author><author>Tsimikas, S.</author><author>Hajsadeghi, F.</author><author>Saeed, A.</author><author>Nabavi, V.</author><author>Bevinal, M. A.</author><author>Kadakia, J.</author><author>Flores, F.</author><author>Ebrahimi, R.</author><author>Budoff, M. J.</author></authors></contributors><auth-address>Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, California, USA.</auth-address><titles><title>Relation of oxidative biomarkers, vascular dysfunction, and progression of coronary artery calcium</title><secondary-title>Am J Cardiol</secondary-title><alt-title>The American journal of cardiology</alt-title></titles><periodical><full-title>Am J Cardiol</full-title><abbr-1>The American journal of cardiology</abbr-1></periodical><alt-periodical><full-title>Am J Cardiol</full-title><abbr-1>The American journal of cardiology</abbr-1></alt-periodical><pages>459-66</pages><volume>105</volume><number>4</number><edition>2010/02/16</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Apolipoprotein B-100/blood</keyword><keyword>Autoantibodies/blood</keyword><keyword>Biological Markers/*blood</keyword><keyword>Calcinosis/*blood/drug therapy/*physiopathology/radiography</keyword><keyword>Calcium/blood</keyword><keyword>Coronary Artery Disease/*blood/drug therapy/*physiopathology/radiography</keyword><keyword>Dietary Supplements</keyword><keyword>Disease Progression</keyword><keyword>Double-Blind Method</keyword><keyword>Equipment Design</keyword><keyword>Female</keyword><keyword>Fingers/*blood supply</keyword><keyword>Follow-Up Studies</keyword><keyword>*Garlic</keyword><keyword>Humans</keyword><keyword>Immunoglobulin G/blood</keyword><keyword>Immunoglobulin M/blood</keyword><keyword>Lipoprotein(a)/blood</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Oxidative Stress/drug effects</keyword><keyword>Phospholipids/blood</keyword><keyword>Phytotherapy</keyword><keyword>Plant Extracts/therapeutic use</keyword><keyword>Predictive Value of Tests</keyword><keyword>Severity of Illness Index</keyword><keyword>*Skin Temperature</keyword><keyword>Thermography/methods</keyword><keyword>Treatment Outcome</keyword><keyword>Vitamin B Complex/therapeutic use</keyword></keywords><dates><year>2010</year><pub-dates><date>Feb 15</date></pub-dates></dates><isbn>1879-1913 (Electronic)&#xD;0002-9149 (Linking)</isbn><accession-num>20152239</accession-num><work-type>Randomized Controlled Trial</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/20152239</url></related-urls></urls><electronic-resource-num>10.1016/j.amjcard.2009.09.052</electronic-resource-num><language>eng</language></record></Cite></EndNote>�D<EndNote><Cite><Author>Wilson</Author><Year>1998</Year><RecNum>72</RecNum><DisplayText>[8]</DisplayText><record><rec-number>72</rec-number><foreign-keys><key app="EN" db-id="2aed0r9epzed9oezvslvedzj99vsdarv0rae" timestamp="1392565330">72</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wilson, P. W.</author><author>D&apos;Agostino, R. B.</author><author>Levy, D.</author><author>Belanger, A. M.</author><author>Silbershatz, H.</author><author>Kannel, W. B.</author></authors></contributors><auth-address>Framingham Heart Study, National Heart, Lung, and Blood Institute, Mass 01701, USA. peter@fram.nhlbi.nih.gov</auth-address><titles><title>Prediction of coronary heart disease using risk factor categories</title><secondary-title>Circulation</secondary-title><alt-title>Circulation</alt-title></titles><periodical><full-title>Circulation</full-title><abbr-1>Circulation</abbr-1></periodical><alt-periodical><full-title>Circulation</full-title><abbr-1>Circulation</abbr-1></alt-periodical><pages>1837-47</pages><volume>97</volume><number>18</number><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Algorithms</keyword><keyword>*Blood Pressure</keyword><keyword>Body Mass Index</keyword><keyword>Cholesterol/*blood</keyword><keyword>Cholesterol, LDL/classification</keyword><keyword>Cohort Studies</keyword><keyword>Comorbidity</keyword><keyword>Coronary Disease/*epidemiology</keyword><keyword>Diabetes Mellitus/epidemiology</keyword><keyword>Female</keyword><keyword>Follow-Up Studies</keyword><keyword>Humans</keyword><keyword>Lipids/blood</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>National Health Programs</keyword><keyword>Proportional Hazards Models</keyword><keyword>Risk Factors</keyword><keyword>Smoking/epidemiology</keyword></keywords><dates><year>1998</year><pub-dates><date>May 12</date></pub-dates></dates><isbn>0009-7322 (Print)&#xD;0009-7322 (Linking)</isbn><accession-num>9603539</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/9603539</url></related-urls></urls></record></Cite></EndNote>�D<EndNote><Cite><Author>Wilson</Author><Year>1998</Year><RecNum>72</RecNum><DisplayText>[8]</DisplayText><record><rec-number>72</rec-number><foreign-keys><key app="EN" db-id="2aed0r9epzed9oezvslvedzj99vsdarv0rae" timestamp="1392565330">72</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wilson, P. W.</author><author>D&apos;Agostino, R. B.</author><author>Levy, D.</author><author>Belanger, A. M.</author><author>Silbershatz, H.</author><author>Kannel, W. B.</author></authors></contributors><auth-address>Framingham Heart Study, National Heart, Lung, and Blood Institute, Mass 01701, USA. peter@fram.nhlbi.nih.gov</auth-address><titles><title>Prediction of coronary heart disease using risk factor categories</title><secondary-title>Circulation</secondary-title><alt-title>Circulation</alt-title></titles><periodical><full-title>Circulation</full-title><abbr-1>Circulation</abbr-1></periodical><alt-periodical><full-title>Circulation</full-title><abbr-1>Circulation</abbr-1></alt-periodical><pages>1837-47</pages><volume>97</volume><number>18</number><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Algorithms</keyword><keyword>*Blood Pressure</keyword><keyword>Body Mass Index</keyword><keyword>Cholesterol/*blood</keyword><keyword>Cholesterol, LDL/classification</keyword><keyword>Cohort Studies</keyword><keyword>Comorbidity</keyword><keyword>Coronary Disease/*epidemiology</keyword><keyword>Diabetes Mellitus/epidemiology</keyword><keyword>Female</keyword><keyword>Follow-Up Studies</keyword><keyword>Humans</keyword><keyword>Lipids/blood</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>National Health Programs</keyword><keyword>Proportional Hazards Models</keyword><keyword>Risk Factors</keyword><keyword>Smoking/epidemiology</keyword></keywords><dates><year>1998</year><pub-dates><date>May 12</date></pub-dates></dates><isbn>0009-7322 (Print)&#xD;0009-7322 (Linking)</isbn><accession-num>9603539</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/9603539</url></related-urls></urls></record></Cite></EndNote>V	D<EndNote><Cite><Author>Raggi</Author><Year>2004</Year><RecNum>11</RecNum><DisplayText>[9]</DisplayText><record><rec-number>11</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">11</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Raggi, P.</author><author>Callister, T. Q.</author><author>Shaw, L. J.</author></authors></contributors><auth-address>Tulane University School of Medicine, New Orleans, La, USA. praggi@tulane.edu</auth-address><titles><title>Progression of coronary artery calcium and risk of first myocardial infarction in patients receiving cholesterol-lowering therapy</title><secondary-title>Arterioscler Thromb Vasc Biol</secondary-title></titles><periodical><full-title>Arterioscler Thromb Vasc Biol</full-title></periodical><pages>1272-7</pages><volume>24</volume><number>7</number><edition>2004/04/03</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Anticholesteremic Agents/pharmacology/*therapeutic use</keyword><keyword>Calcinosis/blood/*epidemiology/radiography</keyword><keyword>Coronary Artery Disease/blood/*epidemiology/radiography</keyword><keyword>Disease Progression</keyword><keyword>Disease-Free Survival</keyword><keyword>Drug Resistance</keyword><keyword>Female</keyword><keyword>Follow-Up Studies</keyword><keyword>Humans</keyword><keyword>Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology/*therapeutic</keyword><keyword>use</keyword><keyword>Hypercholesterolemia/complications/*drug therapy</keyword><keyword>Lipoproteins, LDL/blood</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Myocardial Infarction/*epidemiology/etiology</keyword><keyword>Proportional Hazards Models</keyword><keyword>Risk</keyword><keyword>Tomography, X-Ray Computed</keyword></keywords><dates><year>2004</year><pub-dates><date>Jul</date></pub-dates></dates><isbn>1524-4636 (Electronic)</isbn><accession-num>15059806</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=15059806</url></related-urls></urls><electronic-resource-num>10.1161/01.ATV.0000127024.40516.ef&#xD;01.ATV.0000127024.40516.ef [pii]</electronic-resource-num><language>eng</language></record></Cite></EndNote>V	D<EndNote><Cite><Author>Raggi</Author><Year>2004</Year><RecNum>11</RecNum><DisplayText>[9]</DisplayText><record><rec-number>11</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">11</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Raggi, P.</author><author>Callister, T. Q.</author><author>Shaw, L. J.</author></authors></contributors><auth-address>Tulane University School of Medicine, New Orleans, La, USA. praggi@tulane.edu</auth-address><titles><title>Progression of coronary artery calcium and risk of first myocardial infarction in patients receiving cholesterol-lowering therapy</title><secondary-title>Arterioscler Thromb Vasc Biol</secondary-title></titles><periodical><full-title>Arterioscler Thromb Vasc Biol</full-title></periodical><pages>1272-7</pages><volume>24</volume><number>7</number><edition>2004/04/03</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Anticholesteremic Agents/pharmacology/*therapeutic use</keyword><keyword>Calcinosis/blood/*epidemiology/radiography</keyword><keyword>Coronary Artery Disease/blood/*epidemiology/radiography</keyword><keyword>Disease Progression</keyword><keyword>Disease-Free Survival</keyword><keyword>Drug Resistance</keyword><keyword>Female</keyword><keyword>Follow-Up Studies</keyword><keyword>Humans</keyword><keyword>Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology/*therapeutic</keyword><keyword>use</keyword><keyword>Hypercholesterolemia/complications/*drug therapy</keyword><keyword>Lipoproteins, LDL/blood</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Myocardial Infarction/*epidemiology/etiology</keyword><keyword>Proportional Hazards Models</keyword><keyword>Risk</keyword><keyword>Tomography, X-Ray Computed</keyword></keywords><dates><year>2004</year><pub-dates><date>Jul</date></pub-dates></dates><isbn>1524-4636 (Electronic)</isbn><accession-num>15059806</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=15059806</url></related-urls></urls><electronic-resource-num>10.1161/01.ATV.0000127024.40516.ef&#xD;01.ATV.0000127024.40516.ef [pii]</electronic-resource-num><language>eng</language></record></Cite></EndNote>xD<EndNote><Cite><Author>Budoff</Author><Year>2010</Year><RecNum>12</RecNum><DisplayText>[10]</DisplayText><record><rec-number>12</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">12</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Budoff, M. J.</author><author>Hamirani, Y. S.</author><author>Gao, Y. L.</author><author>Ismaeel, H.</author><author>Flores, F. R.</author><author>Child, J.</author><author>Carson, S.</author><author>Nee, J. N.</author><author>Mao, S.</author></authors></contributors><auth-address>Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W Carson St, Torrance, CA 90502, USA. mbudoff @labiomed.org</auth-address><titles><title>Measurement of thoracic bone mineral density with quantitative CT</title><secondary-title>Radiology</secondary-title><alt-title>Radiology</alt-title></titles><periodical><full-title>Radiology</full-title><abbr-1>Radiology</abbr-1></periodical><alt-periodical><full-title>Radiology</full-title><abbr-1>Radiology</abbr-1></alt-periodical><pages>434-40</pages><volume>257</volume><number>2</number><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>*Bone Density</keyword><keyword>Electrocardiography</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Lumbar Vertebrae/radiography</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Osteoporosis/*radiography</keyword><keyword>Phantoms, Imaging</keyword><keyword>Reproducibility of Results</keyword><keyword>Thoracic Vertebrae/*radiography</keyword><keyword>Tomography, X-Ray Computed/*methods</keyword></keywords><dates><year>2010</year><pub-dates><date>Nov</date></pub-dates></dates><isbn>1527-1315 (Electronic)&#xD;0033-8419 (Linking)</isbn><accession-num>20807844</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/20807844</url></related-urls></urls><electronic-resource-num>10.1148/radiol.10100132</electronic-resource-num></record></Cite></EndNote>xD<EndNote><Cite><Author>Budoff</Author><Year>2010</Year><RecNum>12</RecNum><DisplayText>[10]</DisplayText><record><rec-number>12</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">12</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Budoff, M. J.</author><author>Hamirani, Y. S.</author><author>Gao, Y. L.</author><author>Ismaeel, H.</author><author>Flores, F. R.</author><author>Child, J.</author><author>Carson, S.</author><author>Nee, J. N.</author><author>Mao, S.</author></authors></contributors><auth-address>Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W Carson St, Torrance, CA 90502, USA. mbudoff @labiomed.org</auth-address><titles><title>Measurement of thoracic bone mineral density with quantitative CT</title><secondary-title>Radiology</secondary-title><alt-title>Radiology</alt-title></titles><periodical><full-title>Radiology</full-title><abbr-1>Radiology</abbr-1></periodical><alt-periodical><full-title>Radiology</full-title><abbr-1>Radiology</abbr-1></alt-periodical><pages>434-40</pages><volume>257</volume><number>2</number><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>*Bone Density</keyword><keyword>Electrocardiography</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Lumbar Vertebrae/radiography</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Osteoporosis/*radiography</keyword><keyword>Phantoms, Imaging</keyword><keyword>Reproducibility of Results</keyword><keyword>Thoracic Vertebrae/*radiography</keyword><keyword>Tomography, X-Ray Computed/*methods</keyword></keywords><dates><year>2010</year><pub-dates><date>Nov</date></pub-dates></dates><isbn>1527-1315 (Electronic)&#xD;0033-8419 (Linking)</isbn><accession-num>20807844</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/20807844</url></related-urls></urls><electronic-resource-num>10.1148/radiol.10100132</electronic-resource-num></record></Cite></EndNote>D<EndNote><Cite><Author>Libby</Author><Year>2010</Year><RecNum>13</RecNum><DisplayText>[11-13]</DisplayText><record><rec-number>13</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">13</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Libby, P.</author><author>Okamoto, Y.</author><author>Rocha, V. Z.</author><author>Folco, E.</author></authors></contributors><auth-address>Division of Cardiovascular Medicine, Brigham and Women&apos;s Hospital, Harvard Medical School, Boston, MA 02115, USA. plibby@rics.bwh.harvard.edu</auth-address><titles><title>Inflammation in atherosclerosis: transition from theory to practice</title><secondary-title>Circ J</secondary-title><alt-title>Circulation journal : official journal of the Japanese Circulation Society</alt-title></titles><periodical><full-title>Circ J</full-title><abbr-1>Circulation journal : official journal of the Japanese Circulation Society</abbr-1></periodical><alt-periodical><full-title>Circ J</full-title><abbr-1>Circulation journal : official journal of the Japanese Circulation Society</abbr-1></alt-periodical><pages>213-20</pages><volume>74</volume><number>2</number><edition>2010/01/13</edition><keywords><keyword>Adaptive Immunity</keyword><keyword>Adiponectin/metabolism</keyword><keyword>Adipose Tissue/immunology</keyword><keyword>Animals</keyword><keyword>Anti-Inflammatory Agents/therapeutic use</keyword><keyword>Atherosclerosis/complications/drug therapy/*immunology</keyword><keyword>Cardiovascular Agents/therapeutic use</keyword><keyword>Cardiovascular Diseases/*immunology/prevention &amp; control</keyword><keyword>Humans</keyword><keyword>Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use</keyword><keyword>Immunity, Innate</keyword><keyword>Inflammation/complications/drug therapy/*immunology</keyword><keyword>Inflammation Mediators/*metabolism</keyword><keyword>Monocytes/immunology</keyword><keyword>Obesity/immunology</keyword><keyword>Risk Factors</keyword><keyword>*Signal Transduction/drug effects</keyword><keyword>Thrombosis/immunology</keyword><keyword>Translational Medical Research</keyword></keywords><dates><year>2010</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1347-4820 (Electronic)&#xD;1346-9843 (Linking)</isbn><accession-num>20065609</accession-num><work-type>Review</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/20065609</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Czerny</Author><Year>2010</Year><RecNum>14</RecNum><record><rec-number>14</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">14</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Czerny, B.</author><author>Kaminski, A.</author><author>Kurzawski, M.</author><author>Kotrych, D.</author><author>Safranow, K.</author><author>Dziedziejko, V.</author><author>Bohatyrewicz, A.</author><author>Pawlik, A.</author></authors></contributors><auth-address>Department of Pharmacology, Pomeranian Medical University, ul. Powst. Wlkp. 72, 70-111 Szczecin, Poland.</auth-address><titles><title>The association of IL-1beta, IL-2, and IL-6 gene polymorphisms with bone mineral density and osteoporosis in postmenopausal women</title><secondary-title>Eur J Obstet Gynecol Reprod Biol</secondary-title><alt-title>European journal of obstetrics, gynecology, and reproductive biology</alt-title></titles><periodical><full-title>Eur J Obstet Gynecol Reprod Biol</full-title><abbr-1>European journal of obstetrics, gynecology, and reproductive biology</abbr-1></periodical><alt-periodical><full-title>Eur J Obstet Gynecol Reprod Biol</full-title><abbr-1>European journal of obstetrics, gynecology, and reproductive biology</abbr-1></alt-periodical><pages>82-5</pages><volume>149</volume><number>1</number><edition>2010/01/12</edition><keywords><keyword>Alleles</keyword><keyword>Analysis of Variance</keyword><keyword>Bone Density/*genetics</keyword><keyword>Female</keyword><keyword>Genetic Association Studies</keyword><keyword>Genotype</keyword><keyword>Humans</keyword><keyword>Interleukin-1beta/*genetics</keyword><keyword>Interleukin-2/*genetics</keyword><keyword>Interleukin-6/*genetics</keyword><keyword>Osteoporosis, Postmenopausal/*genetics</keyword><keyword>Poland</keyword><keyword>Polymorphism, Single Nucleotide/genetics</keyword><keyword>Postmenopause/*genetics</keyword><keyword>Statistics, Nonparametric</keyword></keywords><dates><year>2010</year><pub-dates><date>Mar</date></pub-dates></dates><isbn>1872-7654 (Electronic)&#xD;0301-2115 (Linking)</isbn><accession-num>20060205</accession-num><work-type>Research Support, Non-U.S. Gov&apos;t</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/20060205</url></related-urls></urls><electronic-resource-num>10.1016/j.ejogrb.2009.12.010</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>McFarlane</Author><Year>2004</Year><RecNum>15</RecNum><record><rec-number>15</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">15</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>McFarlane, S. I.</author><author>Muniyappa, R.</author><author>Shin, J. J.</author><author>Bahtiyar, G.</author><author>Sowers, J. R.</author></authors></contributors><auth-address>Department of Internal Medicine, Division of Endocrinology, SUNY-Downstate, and Kings County Hospital Center, Brooklyn, NY 11203, USA. immgss@aol.com</auth-address><titles><title>Osteoporosis and cardiovascular disease: brittle bones and boned arteries, is there a link?</title><secondary-title>Endocrine</secondary-title><alt-title>Endocrine</alt-title></titles><periodical><full-title>Endocrine</full-title><abbr-1>Endocrine</abbr-1></periodical><alt-periodical><full-title>Endocrine</full-title><abbr-1>Endocrine</abbr-1></alt-periodical><pages>1-10</pages><volume>23</volume><number>1</number><keywords><keyword>Cardiovascular Diseases/drug therapy/*metabolism/pathology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Osteoporosis/drug therapy/*metabolism/pathology</keyword></keywords><dates><year>2004</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1355-008X (Print)&#xD;1355-008X (Linking)</isbn><accession-num>15034190</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/15034190</url></related-urls></urls><electronic-resource-num>10.1385/ENDO:23:1:01</electronic-resource-num></record></Cite></EndNote>D<EndNote><Cite><Author>Libby</Author><Year>2010</Year><RecNum>13</RecNum><DisplayText>[11-13]</DisplayText><record><rec-number>13</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">13</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Libby, P.</author><author>Okamoto, Y.</author><author>Rocha, V. Z.</author><author>Folco, E.</author></authors></contributors><auth-address>Division of Cardiovascular Medicine, Brigham and Women&apos;s Hospital, Harvard Medical School, Boston, MA 02115, USA. plibby@rics.bwh.harvard.edu</auth-address><titles><title>Inflammation in atherosclerosis: transition from theory to practice</title><secondary-title>Circ J</secondary-title><alt-title>Circulation journal : official journal of the Japanese Circulation Society</alt-title></titles><periodical><full-title>Circ J</full-title><abbr-1>Circulation journal : official journal of the Japanese Circulation Society</abbr-1></periodical><alt-periodical><full-title>Circ J</full-title><abbr-1>Circulation journal : official journal of the Japanese Circulation Society</abbr-1></alt-periodical><pages>213-20</pages><volume>74</volume><number>2</number><edition>2010/01/13</edition><keywords><keyword>Adaptive Immunity</keyword><keyword>Adiponectin/metabolism</keyword><keyword>Adipose Tissue/immunology</keyword><keyword>Animals</keyword><keyword>Anti-Inflammatory Agents/therapeutic use</keyword><keyword>Atherosclerosis/complications/drug therapy/*immunology</keyword><keyword>Cardiovascular Agents/therapeutic use</keyword><keyword>Cardiovascular Diseases/*immunology/prevention &amp; control</keyword><keyword>Humans</keyword><keyword>Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use</keyword><keyword>Immunity, Innate</keyword><keyword>Inflammation/complications/drug therapy/*immunology</keyword><keyword>Inflammation Mediators/*metabolism</keyword><keyword>Monocytes/immunology</keyword><keyword>Obesity/immunology</keyword><keyword>Risk Factors</keyword><keyword>*Signal Transduction/drug effects</keyword><keyword>Thrombosis/immunology</keyword><keyword>Translational Medical Research</keyword></keywords><dates><year>2010</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1347-4820 (Electronic)&#xD;1346-9843 (Linking)</isbn><accession-num>20065609</accession-num><work-type>Review</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/20065609</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Czerny</Author><Year>2010</Year><RecNum>14</RecNum><record><rec-number>14</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">14</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Czerny, B.</author><author>Kaminski, A.</author><author>Kurzawski, M.</author><author>Kotrych, D.</author><author>Safranow, K.</author><author>Dziedziejko, V.</author><author>Bohatyrewicz, A.</author><author>Pawlik, A.</author></authors></contributors><auth-address>Department of Pharmacology, Pomeranian Medical University, ul. Powst. Wlkp. 72, 70-111 Szczecin, Poland.</auth-address><titles><title>The association of IL-1beta, IL-2, and IL-6 gene polymorphisms with bone mineral density and osteoporosis in postmenopausal women</title><secondary-title>Eur J Obstet Gynecol Reprod Biol</secondary-title><alt-title>European journal of obstetrics, gynecology, and reproductive biology</alt-title></titles><periodical><full-title>Eur J Obstet Gynecol Reprod Biol</full-title><abbr-1>European journal of obstetrics, gynecology, and reproductive biology</abbr-1></periodical><alt-periodical><full-title>Eur J Obstet Gynecol Reprod Biol</full-title><abbr-1>European journal of obstetrics, gynecology, and reproductive biology</abbr-1></alt-periodical><pages>82-5</pages><volume>149</volume><number>1</number><edition>2010/01/12</edition><keywords><keyword>Alleles</keyword><keyword>Analysis of Variance</keyword><keyword>Bone Density/*genetics</keyword><keyword>Female</keyword><keyword>Genetic Association Studies</keyword><keyword>Genotype</keyword><keyword>Humans</keyword><keyword>Interleukin-1beta/*genetics</keyword><keyword>Interleukin-2/*genetics</keyword><keyword>Interleukin-6/*genetics</keyword><keyword>Osteoporosis, Postmenopausal/*genetics</keyword><keyword>Poland</keyword><keyword>Polymorphism, Single Nucleotide/genetics</keyword><keyword>Postmenopause/*genetics</keyword><keyword>Statistics, Nonparametric</keyword></keywords><dates><year>2010</year><pub-dates><date>Mar</date></pub-dates></dates><isbn>1872-7654 (Electronic)&#xD;0301-2115 (Linking)</isbn><accession-num>20060205</accession-num><work-type>Research Support, Non-U.S. Gov&apos;t</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/20060205</url></related-urls></urls><electronic-resource-num>10.1016/j.ejogrb.2009.12.010</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>McFarlane</Author><Year>2004</Year><RecNum>15</RecNum><record><rec-number>15</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">15</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>McFarlane, S. I.</author><author>Muniyappa, R.</author><author>Shin, J. J.</author><author>Bahtiyar, G.</author><author>Sowers, J. R.</author></authors></contributors><auth-address>Department of Internal Medicine, Division of Endocrinology, SUNY-Downstate, and Kings County Hospital Center, Brooklyn, NY 11203, USA. immgss@aol.com</auth-address><titles><title>Osteoporosis and cardiovascular disease: brittle bones and boned arteries, is there a link?</title><secondary-title>Endocrine</secondary-title><alt-title>Endocrine</alt-title></titles><periodical><full-title>Endocrine</full-title><abbr-1>Endocrine</abbr-1></periodical><alt-periodical><full-title>Endocrine</full-title><abbr-1>Endocrine</abbr-1></alt-periodical><pages>1-10</pages><volume>23</volume><number>1</number><keywords><keyword>Cardiovascular Diseases/drug therapy/*metabolism/pathology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Osteoporosis/drug therapy/*metabolism/pathology</keyword></keywords><dates><year>2004</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1355-008X (Print)&#xD;1355-008X (Linking)</isbn><accession-num>15034190</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/15034190</url></related-urls></urls><electronic-resource-num>10.1385/ENDO:23:1:01</electronic-resource-num></record></Cite></EndNote>bD<EndNote><Cite><Author>Czerny</Author><Year>2010</Year><RecNum>14</RecNum><DisplayText>[12, 13]</DisplayText><record><rec-number>14</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">14</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Czerny, B.</author><author>Kaminski, A.</author><author>Kurzawski, M.</author><author>Kotrych, D.</author><author>Safranow, K.</author><author>Dziedziejko, V.</author><author>Bohatyrewicz, A.</author><author>Pawlik, A.</author></authors></contributors><auth-address>Department of Pharmacology, Pomeranian Medical University, ul. Powst. Wlkp. 72, 70-111 Szczecin, Poland.</auth-address><titles><title>The association of IL-1beta, IL-2, and IL-6 gene polymorphisms with bone mineral density and osteoporosis in postmenopausal women</title><secondary-title>Eur J Obstet Gynecol Reprod Biol</secondary-title><alt-title>European journal of obstetrics, gynecology, and reproductive biology</alt-title></titles><periodical><full-title>Eur J Obstet Gynecol Reprod Biol</full-title><abbr-1>European journal of obstetrics, gynecology, and reproductive biology</abbr-1></periodical><alt-periodical><full-title>Eur J Obstet Gynecol Reprod Biol</full-title><abbr-1>European journal of obstetrics, gynecology, and reproductive biology</abbr-1></alt-periodical><pages>82-5</pages><volume>149</volume><number>1</number><edition>2010/01/12</edition><keywords><keyword>Alleles</keyword><keyword>Analysis of Variance</keyword><keyword>Bone Density/*genetics</keyword><keyword>Female</keyword><keyword>Genetic Association Studies</keyword><keyword>Genotype</keyword><keyword>Humans</keyword><keyword>Interleukin-1beta/*genetics</keyword><keyword>Interleukin-2/*genetics</keyword><keyword>Interleukin-6/*genetics</keyword><keyword>Osteoporosis, Postmenopausal/*genetics</keyword><keyword>Poland</keyword><keyword>Polymorphism, Single Nucleotide/genetics</keyword><keyword>Postmenopause/*genetics</keyword><keyword>Statistics, Nonparametric</keyword></keywords><dates><year>2010</year><pub-dates><date>Mar</date></pub-dates></dates><isbn>1872-7654 (Electronic)&#xD;0301-2115 (Linking)</isbn><accession-num>20060205</accession-num><work-type>Research Support, Non-U.S. Gov&apos;t</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/20060205</url></related-urls></urls><electronic-resource-num>10.1016/j.ejogrb.2009.12.010</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>McFarlane</Author><Year>2004</Year><RecNum>15</RecNum><record><rec-number>15</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">15</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>McFarlane, S. I.</author><author>Muniyappa, R.</author><author>Shin, J. J.</author><author>Bahtiyar, G.</author><author>Sowers, J. R.</author></authors></contributors><auth-address>Department of Internal Medicine, Division of Endocrinology, SUNY-Downstate, and Kings County Hospital Center, Brooklyn, NY 11203, USA. immgss@aol.com</auth-address><titles><title>Osteoporosis and cardiovascular disease: brittle bones and boned arteries, is there a link?</title><secondary-title>Endocrine</secondary-title><alt-title>Endocrine</alt-title></titles><periodical><full-title>Endocrine</full-title><abbr-1>Endocrine</abbr-1></periodical><alt-periodical><full-title>Endocrine</full-title><abbr-1>Endocrine</abbr-1></alt-periodical><pages>1-10</pages><volume>23</volume><number>1</number><keywords><keyword>Cardiovascular Diseases/drug therapy/*metabolism/pathology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Osteoporosis/drug therapy/*metabolism/pathology</keyword></keywords><dates><year>2004</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1355-008X (Print)&#xD;1355-008X (Linking)</isbn><accession-num>15034190</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/15034190</url></related-urls></urls><electronic-resource-num>10.1385/ENDO:23:1:01</electronic-resource-num></record></Cite></EndNote>bD<EndNote><Cite><Author>Czerny</Author><Year>2010</Year><RecNum>14</RecNum><DisplayText>[12, 13]</DisplayText><record><rec-number>14</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">14</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Czerny, B.</author><author>Kaminski, A.</author><author>Kurzawski, M.</author><author>Kotrych, D.</author><author>Safranow, K.</author><author>Dziedziejko, V.</author><author>Bohatyrewicz, A.</author><author>Pawlik, A.</author></authors></contributors><auth-address>Department of Pharmacology, Pomeranian Medical University, ul. Powst. Wlkp. 72, 70-111 Szczecin, Poland.</auth-address><titles><title>The association of IL-1beta, IL-2, and IL-6 gene polymorphisms with bone mineral density and osteoporosis in postmenopausal women</title><secondary-title>Eur J Obstet Gynecol Reprod Biol</secondary-title><alt-title>European journal of obstetrics, gynecology, and reproductive biology</alt-title></titles><periodical><full-title>Eur J Obstet Gynecol Reprod Biol</full-title><abbr-1>European journal of obstetrics, gynecology, and reproductive biology</abbr-1></periodical><alt-periodical><full-title>Eur J Obstet Gynecol Reprod Biol</full-title><abbr-1>European journal of obstetrics, gynecology, and reproductive biology</abbr-1></alt-periodical><pages>82-5</pages><volume>149</volume><number>1</number><edition>2010/01/12</edition><keywords><keyword>Alleles</keyword><keyword>Analysis of Variance</keyword><keyword>Bone Density/*genetics</keyword><keyword>Female</keyword><keyword>Genetic Association Studies</keyword><keyword>Genotype</keyword><keyword>Humans</keyword><keyword>Interleukin-1beta/*genetics</keyword><keyword>Interleukin-2/*genetics</keyword><keyword>Interleukin-6/*genetics</keyword><keyword>Osteoporosis, Postmenopausal/*genetics</keyword><keyword>Poland</keyword><keyword>Polymorphism, Single Nucleotide/genetics</keyword><keyword>Postmenopause/*genetics</keyword><keyword>Statistics, Nonparametric</keyword></keywords><dates><year>2010</year><pub-dates><date>Mar</date></pub-dates></dates><isbn>1872-7654 (Electronic)&#xD;0301-2115 (Linking)</isbn><accession-num>20060205</accession-num><work-type>Research Support, Non-U.S. Gov&apos;t</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/20060205</url></related-urls></urls><electronic-resource-num>10.1016/j.ejogrb.2009.12.010</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>McFarlane</Author><Year>2004</Year><RecNum>15</RecNum><record><rec-number>15</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">15</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>McFarlane, S. I.</author><author>Muniyappa, R.</author><author>Shin, J. J.</author><author>Bahtiyar, G.</author><author>Sowers, J. R.</author></authors></contributors><auth-address>Department of Internal Medicine, Division of Endocrinology, SUNY-Downstate, and Kings County Hospital Center, Brooklyn, NY 11203, USA. immgss@aol.com</auth-address><titles><title>Osteoporosis and cardiovascular disease: brittle bones and boned arteries, is there a link?</title><secondary-title>Endocrine</secondary-title><alt-title>Endocrine</alt-title></titles><periodical><full-title>Endocrine</full-title><abbr-1>Endocrine</abbr-1></periodical><alt-periodical><full-title>Endocrine</full-title><abbr-1>Endocrine</abbr-1></alt-periodical><pages>1-10</pages><volume>23</volume><number>1</number><keywords><keyword>Cardiovascular Diseases/drug therapy/*metabolism/pathology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Osteoporosis/drug therapy/*metabolism/pathology</keyword></keywords><dates><year>2004</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1355-008X (Print)&#xD;1355-008X (Linking)</isbn><accession-num>15034190</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/15034190</url></related-urls></urls><electronic-resource-num>10.1385/ENDO:23:1:01</electronic-resource-num></record></Cite></EndNote>
D<EndNote><Cite><Author>Ersoy</Author><Year>2008</Year><RecNum>18</RecNum><DisplayText>[15]</DisplayText><record><rec-number>18</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">18</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ersoy, C.</author><author>Kiyici, S.</author><author>Budak, F.</author><author>Oral, B.</author><author>Guclu, M.</author><author>Duran, C.</author><author>Selimoglu, H.</author><author>Erturk, E.</author><author>Tuncel, E.</author><author>Imamoglu, S.</author></authors></contributors><auth-address>Department of Endocrinology and Metabolism, Uludag University Medical School, 16059 Gorukle-Bursa, Turkey. ecanan@uludag.edu.tr</auth-address><titles><title>The effect of metformin treatment on VEGF and PAI-1 levels in obese type 2 diabetic patients</title><secondary-title>Diabetes Res Clin Pract</secondary-title><alt-title>Diabetes research and clinical practice</alt-title></titles><periodical><full-title>Diabetes Res Clin Pract</full-title><abbr-1>Diabetes research and clinical practice</abbr-1></periodical><alt-periodical><full-title>Diabetes Res Clin Pract</full-title><abbr-1>Diabetes research and clinical practice</abbr-1></alt-periodical><pages>56-60</pages><volume>81</volume><number>1</number><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Blood Glucose/metabolism</keyword><keyword>Body Mass Index</keyword><keyword>Diabetes Mellitus, Type 2/*blood/complications/*drug therapy/physiopathology</keyword><keyword>Exercise</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Hypoglycemic Agents/therapeutic use</keyword><keyword>Lipids/blood</keyword><keyword>Male</keyword><keyword>Matrix Metalloproteinase 9/blood</keyword><keyword>Metformin/*therapeutic use</keyword><keyword>Middle Aged</keyword><keyword>Obesity/*blood/complications/physiopathology</keyword><keyword>Plasminogen Activator Inhibitor 1/*blood</keyword><keyword>Prospective Studies</keyword><keyword>Vascular Endothelial Growth Factor A/*blood</keyword><keyword>Waist-Hip Ratio</keyword></keywords><dates><year>2008</year><pub-dates><date>Jul</date></pub-dates></dates><isbn>1872-8227 (Electronic)&#xD;0168-8227 (Linking)</isbn><accession-num>18358555</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/18358555</url></related-urls></urls><electronic-resource-num>10.1016/j.diabres.2008.02.006</electronic-resource-num></record></Cite></EndNote>
D<EndNote><Cite><Author>Ersoy</Author><Year>2008</Year><RecNum>18</RecNum><DisplayText>[15]</DisplayText><record><rec-number>18</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">18</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ersoy, C.</author><author>Kiyici, S.</author><author>Budak, F.</author><author>Oral, B.</author><author>Guclu, M.</author><author>Duran, C.</author><author>Selimoglu, H.</author><author>Erturk, E.</author><author>Tuncel, E.</author><author>Imamoglu, S.</author></authors></contributors><auth-address>Department of Endocrinology and Metabolism, Uludag University Medical School, 16059 Gorukle-Bursa, Turkey. ecanan@uludag.edu.tr</auth-address><titles><title>The effect of metformin treatment on VEGF and PAI-1 levels in obese type 2 diabetic patients</title><secondary-title>Diabetes Res Clin Pract</secondary-title><alt-title>Diabetes research and clinical practice</alt-title></titles><periodical><full-title>Diabetes Res Clin Pract</full-title><abbr-1>Diabetes research and clinical practice</abbr-1></periodical><alt-periodical><full-title>Diabetes Res Clin Pract</full-title><abbr-1>Diabetes research and clinical practice</abbr-1></alt-periodical><pages>56-60</pages><volume>81</volume><number>1</number><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Blood Glucose/metabolism</keyword><keyword>Body Mass Index</keyword><keyword>Diabetes Mellitus, Type 2/*blood/complications/*drug therapy/physiopathology</keyword><keyword>Exercise</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Hypoglycemic Agents/therapeutic use</keyword><keyword>Lipids/blood</keyword><keyword>Male</keyword><keyword>Matrix Metalloproteinase 9/blood</keyword><keyword>Metformin/*therapeutic use</keyword><keyword>Middle Aged</keyword><keyword>Obesity/*blood/complications/physiopathology</keyword><keyword>Plasminogen Activator Inhibitor 1/*blood</keyword><keyword>Prospective Studies</keyword><keyword>Vascular Endothelial Growth Factor A/*blood</keyword><keyword>Waist-Hip Ratio</keyword></keywords><dates><year>2008</year><pub-dates><date>Jul</date></pub-dates></dates><isbn>1872-8227 (Electronic)&#xD;0168-8227 (Linking)</isbn><accession-num>18358555</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/18358555</url></related-urls></urls><electronic-resource-num>10.1016/j.diabres.2008.02.006</electronic-resource-num></record></Cite></EndNote>&	D<EndNote><Cite><Author>Armour</Author><Year>2001</Year><RecNum>27</RecNum><DisplayText>[16]</DisplayText><record><rec-number>27</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">27</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Armour, K. E.</author><author>Armour, K. J.</author><author>Gallagher, M. E.</author><author>Godecke, A.</author><author>Helfrich, M. H.</author><author>Reid, D. M.</author><author>Ralston, S. H.</author></authors></contributors><auth-address>Department of Medicine and Therapeutics, Foresterhill, University of Aberdeen Medical School, Aberdeen, AB25 2ZD, United Kingdom.</auth-address><titles><title>Defective bone formation and anabolic response to exogenous estrogen in mice with targeted disruption of endothelial nitric oxide synthase</title><secondary-title>Endocrinology</secondary-title><alt-title>Endocrinology</alt-title></titles><periodical><full-title>Endocrinology</full-title><abbr-1>Endocrinology</abbr-1></periodical><alt-periodical><full-title>Endocrinology</full-title><abbr-1>Endocrinology</abbr-1></alt-periodical><pages>760-6</pages><volume>142</volume><number>2</number><keywords><keyword>Alkaline Phosphatase/metabolism</keyword><keyword>Animals</keyword><keyword>Bone Density</keyword><keyword>Bone Development/*physiology</keyword><keyword>Bone and Bones/metabolism/pathology</keyword><keyword>Cell Differentiation/physiology</keyword><keyword>Cell Division/physiology</keyword><keyword>Cells, Cultured</keyword><keyword>Estradiol/*pharmacology</keyword><keyword>Female</keyword><keyword>Male</keyword><keyword>Mice</keyword><keyword>Mice, Inbred C57BL</keyword><keyword>Mice, Knockout/genetics</keyword><keyword>Nitric Oxide Synthase/deficiency/genetics/*physiology</keyword><keyword>Nitric Oxide Synthase Type II</keyword><keyword>Nitric Oxide Synthase Type III</keyword><keyword>Ovariectomy</keyword><keyword>Reference Values</keyword></keywords><dates><year>2001</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>0013-7227 (Print)&#xD;0013-7227 (Linking)</isbn><accession-num>11159848</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/11159848</url></related-urls></urls></record></Cite></EndNote>&	D<EndNote><Cite><Author>Armour</Author><Year>2001</Year><RecNum>27</RecNum><DisplayText>[16]</DisplayText><record><rec-number>27</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">27</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Armour, K. E.</author><author>Armour, K. J.</author><author>Gallagher, M. E.</author><author>Godecke, A.</author><author>Helfrich, M. H.</author><author>Reid, D. M.</author><author>Ralston, S. H.</author></authors></contributors><auth-address>Department of Medicine and Therapeutics, Foresterhill, University of Aberdeen Medical School, Aberdeen, AB25 2ZD, United Kingdom.</auth-address><titles><title>Defective bone formation and anabolic response to exogenous estrogen in mice with targeted disruption of endothelial nitric oxide synthase</title><secondary-title>Endocrinology</secondary-title><alt-title>Endocrinology</alt-title></titles><periodical><full-title>Endocrinology</full-title><abbr-1>Endocrinology</abbr-1></periodical><alt-periodical><full-title>Endocrinology</full-title><abbr-1>Endocrinology</abbr-1></alt-periodical><pages>760-6</pages><volume>142</volume><number>2</number><keywords><keyword>Alkaline Phosphatase/metabolism</keyword><keyword>Animals</keyword><keyword>Bone Density</keyword><keyword>Bone Development/*physiology</keyword><keyword>Bone and Bones/metabolism/pathology</keyword><keyword>Cell Differentiation/physiology</keyword><keyword>Cell Division/physiology</keyword><keyword>Cells, Cultured</keyword><keyword>Estradiol/*pharmacology</keyword><keyword>Female</keyword><keyword>Male</keyword><keyword>Mice</keyword><keyword>Mice, Inbred C57BL</keyword><keyword>Mice, Knockout/genetics</keyword><keyword>Nitric Oxide Synthase/deficiency/genetics/*physiology</keyword><keyword>Nitric Oxide Synthase Type II</keyword><keyword>Nitric Oxide Synthase Type III</keyword><keyword>Ovariectomy</keyword><keyword>Reference Values</keyword></keywords><dates><year>2001</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>0013-7227 (Print)&#xD;0013-7227 (Linking)</isbn><accession-num>11159848</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/11159848</url></related-urls></urls></record></Cite></EndNote>�D<EndNote><Cite><Author>Garrett</Author><Year>2001</Year><RecNum>28</RecNum><DisplayText>[17, 18]</DisplayText><record><rec-number>28</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">28</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Garrett, I. R.</author><author>Gutierrez, G.</author><author>Mundy, G. R.</author></authors></contributors><auth-address>Department of Endocrinology/Medicine, University of Texas Health Science Center at San Antonio, USA. rossos@aol.com</auth-address><titles><title>Statins and bone formation</title><secondary-title>Curr Pharm Des</secondary-title><alt-title>Current pharmaceutical design</alt-title></titles><periodical><full-title>Curr Pharm Des</full-title><abbr-1>Current pharmaceutical design</abbr-1></periodical><alt-periodical><full-title>Curr Pharm Des</full-title><abbr-1>Current pharmaceutical design</abbr-1></alt-periodical><pages>715-36</pages><volume>7</volume><number>8</number><keywords><keyword>Animals</keyword><keyword>Bone Development/*drug effects</keyword><keyword>Endothelium, Vascular/drug effects</keyword><keyword>Humans</keyword><keyword>Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology</keyword><keyword>Inflammation/drug therapy</keyword><keyword>Lovastatin/pharmacology</keyword><keyword>Neoplasms/drug therapy</keyword><keyword>Nitric Oxide Synthase/physiology</keyword><keyword>Pyridines/pharmacology</keyword><keyword>Simvastatin/pharmacology</keyword></keywords><dates><year>2001</year><pub-dates><date>May</date></pub-dates></dates><isbn>1381-6128 (Print)&#xD;1381-6128 (Linking)</isbn><accession-num>11405194</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/11405194</url></related-urls></urls></record></Cite><Cite><Author>Mundy</Author><Year>1999</Year><RecNum>29</RecNum><record><rec-number>29</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">29</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Mundy, G.</author><author>Garrett, R.</author><author>Harris, S.</author><author>Chan, J.</author><author>Chen, D.</author><author>Rossini, G.</author><author>Boyce, B.</author><author>Zhao, M.</author><author>Gutierrez, G.</author></authors></contributors><auth-address>OsteoScreen, 2040 Babcock Road, San Antonio, TX 78229, USA. mundy@uthscsa.edu</auth-address><titles><title>Stimulation of bone formation in vitro and in rodents by statins</title><secondary-title>Science</secondary-title><alt-title>Science</alt-title></titles><periodical><full-title>Science</full-title><abbr-1>Science</abbr-1></periodical><alt-periodical><full-title>Science</full-title><abbr-1>Science</abbr-1></alt-periodical><pages>1946-9</pages><volume>286</volume><number>5446</number><keywords><keyword>Animals</keyword><keyword>Bone Density/*drug effects</keyword><keyword>Bone Morphogenetic Protein 2</keyword><keyword>Bone Morphogenetic Proteins/biosynthesis/genetics/pharmacology</keyword><keyword>Cell Line</keyword><keyword>Female</keyword><keyword>Fibroblast Growth Factor 1</keyword><keyword>Fibroblast Growth Factor 2/pharmacology</keyword><keyword>Humans</keyword><keyword>Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology</keyword><keyword>Lovastatin/*pharmacology</keyword><keyword>Male</keyword><keyword>Mice</keyword><keyword>Mice, Inbred ICR</keyword><keyword>Organ Culture Techniques</keyword><keyword>Osteoblasts/*drug effects/metabolism</keyword><keyword>Osteoclasts/drug effects</keyword><keyword>Osteogenesis/*drug effects</keyword><keyword>Osteoporosis/drug therapy</keyword><keyword>Ovariectomy</keyword><keyword>Promoter Regions, Genetic/drug effects</keyword><keyword>Rats</keyword><keyword>Recombinant Proteins/pharmacology</keyword><keyword>Simvastatin/*pharmacology</keyword><keyword>Skull</keyword><keyword>Transfection</keyword><keyword>*Transforming Growth Factor beta</keyword></keywords><dates><year>1999</year><pub-dates><date>Dec 3</date></pub-dates></dates><isbn>0036-8075 (Print)&#xD;0036-8075 (Linking)</isbn><accession-num>10583956</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/10583956</url></related-urls></urls></record></Cite></EndNote>�D<EndNote><Cite><Author>Garrett</Author><Year>2001</Year><RecNum>28</RecNum><DisplayText>[17, 18]</DisplayText><record><rec-number>28</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">28</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Garrett, I. R.</author><author>Gutierrez, G.</author><author>Mundy, G. R.</author></authors></contributors><auth-address>Department of Endocrinology/Medicine, University of Texas Health Science Center at San Antonio, USA. rossos@aol.com</auth-address><titles><title>Statins and bone formation</title><secondary-title>Curr Pharm Des</secondary-title><alt-title>Current pharmaceutical design</alt-title></titles><periodical><full-title>Curr Pharm Des</full-title><abbr-1>Current pharmaceutical design</abbr-1></periodical><alt-periodical><full-title>Curr Pharm Des</full-title><abbr-1>Current pharmaceutical design</abbr-1></alt-periodical><pages>715-36</pages><volume>7</volume><number>8</number><keywords><keyword>Animals</keyword><keyword>Bone Development/*drug effects</keyword><keyword>Endothelium, Vascular/drug effects</keyword><keyword>Humans</keyword><keyword>Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology</keyword><keyword>Inflammation/drug therapy</keyword><keyword>Lovastatin/pharmacology</keyword><keyword>Neoplasms/drug therapy</keyword><keyword>Nitric Oxide Synthase/physiology</keyword><keyword>Pyridines/pharmacology</keyword><keyword>Simvastatin/pharmacology</keyword></keywords><dates><year>2001</year><pub-dates><date>May</date></pub-dates></dates><isbn>1381-6128 (Print)&#xD;1381-6128 (Linking)</isbn><accession-num>11405194</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/11405194</url></related-urls></urls></record></Cite><Cite><Author>Mundy</Author><Year>1999</Year><RecNum>29</RecNum><record><rec-number>29</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">29</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Mundy, G.</author><author>Garrett, R.</author><author>Harris, S.</author><author>Chan, J.</author><author>Chen, D.</author><author>Rossini, G.</author><author>Boyce, B.</author><author>Zhao, M.</author><author>Gutierrez, G.</author></authors></contributors><auth-address>OsteoScreen, 2040 Babcock Road, San Antonio, TX 78229, USA. mundy@uthscsa.edu</auth-address><titles><title>Stimulation of bone formation in vitro and in rodents by statins</title><secondary-title>Science</secondary-title><alt-title>Science</alt-title></titles><periodical><full-title>Science</full-title><abbr-1>Science</abbr-1></periodical><alt-periodical><full-title>Science</full-title><abbr-1>Science</abbr-1></alt-periodical><pages>1946-9</pages><volume>286</volume><number>5446</number><keywords><keyword>Animals</keyword><keyword>Bone Density/*drug effects</keyword><keyword>Bone Morphogenetic Protein 2</keyword><keyword>Bone Morphogenetic Proteins/biosynthesis/genetics/pharmacology</keyword><keyword>Cell Line</keyword><keyword>Female</keyword><keyword>Fibroblast Growth Factor 1</keyword><keyword>Fibroblast Growth Factor 2/pharmacology</keyword><keyword>Humans</keyword><keyword>Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology</keyword><keyword>Lovastatin/*pharmacology</keyword><keyword>Male</keyword><keyword>Mice</keyword><keyword>Mice, Inbred ICR</keyword><keyword>Organ Culture Techniques</keyword><keyword>Osteoblasts/*drug effects/metabolism</keyword><keyword>Osteoclasts/drug effects</keyword><keyword>Osteogenesis/*drug effects</keyword><keyword>Osteoporosis/drug therapy</keyword><keyword>Ovariectomy</keyword><keyword>Promoter Regions, Genetic/drug effects</keyword><keyword>Rats</keyword><keyword>Recombinant Proteins/pharmacology</keyword><keyword>Simvastatin/*pharmacology</keyword><keyword>Skull</keyword><keyword>Transfection</keyword><keyword>*Transforming Growth Factor beta</keyword></keywords><dates><year>1999</year><pub-dates><date>Dec 3</date></pub-dates></dates><isbn>0036-8075 (Print)&#xD;0036-8075 (Linking)</isbn><accession-num>10583956</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/10583956</url></related-urls></urls></record></Cite></EndNote>�
D<EndNote><Cite><Author>Deckers</Author><Year>2000</Year><RecNum>17</RecNum><DisplayText>[19]</DisplayText><record><rec-number>17</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">17</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Deckers, M. M.</author><author>Karperien, M.</author><author>van der Bent, C.</author><author>Yamashita, T.</author><author>Papapoulos, S. E.</author><author>Lowik, C. W.</author></authors></contributors><auth-address>Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, The Netherlands. m.m.l.deckers@lumc.nl</auth-address><titles><title>Expression of vascular endothelial growth factors and their receptors during osteoblast differentiation</title><secondary-title>Endocrinology</secondary-title><alt-title>Endocrinology</alt-title></titles><periodical><full-title>Endocrinology</full-title><abbr-1>Endocrinology</abbr-1></periodical><alt-periodical><full-title>Endocrinology</full-title><abbr-1>Endocrinology</abbr-1></alt-periodical><pages>1667-74</pages><volume>141</volume><number>5</number><keywords><keyword>Animals</keyword><keyword>Cell Differentiation</keyword><keyword>Cell Line</keyword><keyword>Electrophoresis, Polyacrylamide Gel</keyword><keyword>Endothelial Growth Factors/*biosynthesis/genetics</keyword><keyword>Enzyme-Linked Immunosorbent Assay</keyword><keyword>Humans</keyword><keyword>Insulin-Like Growth Factor I/pharmacology</keyword><keyword>Lymphokines/*biosynthesis</keyword><keyword>Mice</keyword><keyword>Osteoblasts/*physiology</keyword><keyword>Parathyroid Hormone-Related Protein</keyword><keyword>Polymerase Chain Reaction</keyword><keyword>Proteins/pharmacology</keyword><keyword>RNA, Messenger/metabolism</keyword><keyword>Receptor Protein-Tyrosine Kinases/*biosynthesis</keyword><keyword>Receptors, Cell Surface/biosynthesis</keyword><keyword>Receptors, Growth Factor/*biosynthesis</keyword><keyword>Receptors, Vascular Endothelial Growth Factor</keyword><keyword>Vascular Endothelial Growth Factor A</keyword><keyword>Vascular Endothelial Growth Factor B</keyword><keyword>Vascular Endothelial Growth Factor C</keyword><keyword>Vascular Endothelial Growth Factor D</keyword><keyword>Vascular Endothelial Growth Factor Receptor-3</keyword><keyword>Vascular Endothelial Growth Factors</keyword></keywords><dates><year>2000</year><pub-dates><date>May</date></pub-dates></dates><isbn>0013-7227 (Print)&#xD;0013-7227 (Linking)</isbn><accession-num>10803575</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/10803575</url></related-urls></urls></record></Cite></EndNote>�
D<EndNote><Cite><Author>Deckers</Author><Year>2000</Year><RecNum>17</RecNum><DisplayText>[19]</DisplayText><record><rec-number>17</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">17</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Deckers, M. M.</author><author>Karperien, M.</author><author>van der Bent, C.</author><author>Yamashita, T.</author><author>Papapoulos, S. E.</author><author>Lowik, C. W.</author></authors></contributors><auth-address>Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, The Netherlands. m.m.l.deckers@lumc.nl</auth-address><titles><title>Expression of vascular endothelial growth factors and their receptors during osteoblast differentiation</title><secondary-title>Endocrinology</secondary-title><alt-title>Endocrinology</alt-title></titles><periodical><full-title>Endocrinology</full-title><abbr-1>Endocrinology</abbr-1></periodical><alt-periodical><full-title>Endocrinology</full-title><abbr-1>Endocrinology</abbr-1></alt-periodical><pages>1667-74</pages><volume>141</volume><number>5</number><keywords><keyword>Animals</keyword><keyword>Cell Differentiation</keyword><keyword>Cell Line</keyword><keyword>Electrophoresis, Polyacrylamide Gel</keyword><keyword>Endothelial Growth Factors/*biosynthesis/genetics</keyword><keyword>Enzyme-Linked Immunosorbent Assay</keyword><keyword>Humans</keyword><keyword>Insulin-Like Growth Factor I/pharmacology</keyword><keyword>Lymphokines/*biosynthesis</keyword><keyword>Mice</keyword><keyword>Osteoblasts/*physiology</keyword><keyword>Parathyroid Hormone-Related Protein</keyword><keyword>Polymerase Chain Reaction</keyword><keyword>Proteins/pharmacology</keyword><keyword>RNA, Messenger/metabolism</keyword><keyword>Receptor Protein-Tyrosine Kinases/*biosynthesis</keyword><keyword>Receptors, Cell Surface/biosynthesis</keyword><keyword>Receptors, Growth Factor/*biosynthesis</keyword><keyword>Receptors, Vascular Endothelial Growth Factor</keyword><keyword>Vascular Endothelial Growth Factor A</keyword><keyword>Vascular Endothelial Growth Factor B</keyword><keyword>Vascular Endothelial Growth Factor C</keyword><keyword>Vascular Endothelial Growth Factor D</keyword><keyword>Vascular Endothelial Growth Factor Receptor-3</keyword><keyword>Vascular Endothelial Growth Factors</keyword></keywords><dates><year>2000</year><pub-dates><date>May</date></pub-dates></dates><isbn>0013-7227 (Print)&#xD;0013-7227 (Linking)</isbn><accession-num>10803575</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/10803575</url></related-urls></urls></record></Cite></EndNote>�	D<EndNote><Cite><Author>Yeboah</Author><Year>2007</Year><RecNum>20</RecNum><DisplayText>[20]</DisplayText><record><rec-number>20</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">20</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Yeboah, J.</author><author>Crouse, J. R.</author><author>Hsu, F. C.</author><author>Burke, G. L.</author><author>Herrington, D. M.</author></authors></contributors><auth-address>Department of Internal Medicine/Cardiology, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA. jyeboah@wfubmc.edu</auth-address><titles><title>Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study</title><secondary-title>Circulation</secondary-title></titles><periodical><full-title>Circulation</full-title></periodical><pages>2390-7</pages><volume>115</volume><number>18</number><edition>2007/04/25</edition><keywords><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Atherosclerosis/*diagnosis/epidemiology/physiopathology</keyword><keyword>Biological Markers</keyword><keyword>Brachial Artery/*physiopathology/ultrasonography</keyword><keyword>Cardiovascular Diseases/epidemiology</keyword><keyword>Cohort Studies</keyword><keyword>Disease-Free Survival</keyword><keyword>Endothelium, Vascular/*physiopathology</keyword><keyword>Female</keyword><keyword>*Hemorheology</keyword><keyword>Humans</keyword><keyword>Hyperemia/*physiopathology</keyword><keyword>Male</keyword><keyword>Predictive Value of Tests</keyword><keyword>Prognosis</keyword><keyword>Proportional Hazards Models</keyword><keyword>Prospective Studies</keyword><keyword>Reproducibility of Results</keyword><keyword>Risk Factors</keyword><keyword>Stress, Mechanical</keyword�����������������������������������������������������������������������������������������������������������������������������������������������������������������������������������><keyword>Tourniquets</keyword><keyword>United States/epidemiology</keyword><keyword>Vasodilation/*drug effects/physiology</keyword></keywords><dates><year>2007</year><pub-dates><date>May 8</date></pub-dates></dates><isbn>1524-4539 (Electronic)</isbn><accession-num>17452608</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=17452608</url></related-urls></urls><electronic-resource-num>CIRCULATIONAHA.106.678276 [pii]&#xD;10.1161/CIRCULATIONAHA.106.678276</electronic-resource-num><language>eng</language></record></Cite></EndNote>�	D<EndNote><Cite><Author>Yeboah</Author><Year>2007</Year><RecNum>20</RecNum><DisplayText>[20]</DisplayText><record><rec-number>20</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">20</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Yeboah, J.</author><author>Crouse, J. R.</author><author>Hsu, F. C.</author><author>Burke, G. L.</author><author>Herrington, D. M.</author></authors></contributors><auth-address>Department of Internal Medicine/Cardiology, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA. jyeboah@wfubmc.edu</auth-address><titles><title>Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study</title><secondary-title>Circulation</secondary-title></titles><periodical><full-title>Circulation</full-title></periodical><pages>2390-7</pages><volume>115</volume><number>18</number><edition>2007/04/25</edition><keywords><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Atherosclerosis/*diagnosis/epidemiology/physiopathology</keyword><keyword>Biological Markers</keyword><keyword>Brachial Artery/*physiopathology/ultrasonography</keyword><keyword>Cardiovascular Diseases/epidemiology</keyword><keyword>Cohort Studies</keyword><keyword>Disease-Free Survival</keyword><keyword>Endothelium, Vascular/*physiopathology</keyword><keyword>Female</keyword><keyword>*Hemorheology</keyword><keyword>Humans</keyword><keyword>Hyperemia/*physiopathology</keyword><keyword>Male</keyword><keyword>Predictive Value of Tests</keyword><keyword>Prognosis</keyword><keyword>Proportional Hazards Models</keyword><keyword>Prospective Studies</keyword><keyword>Reproducibility of Results</keyword><keyword>Risk Factors</keyword><keyword>Stress, Mechanical</keyword><keyword>Tourniquets</keyword><keyword>United States/epidemiology</keyword><keyword>Vasodilation/*drug effects/physiology</keyword></keywords><dates><year>2007</year><pub-dates><date>May 8</date></pub-dates></dates><isbn>1524-4539 (Electronic)</isbn><accession-num>17452608</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=17452608</url></related-urls></urls><electronic-resource-num>CIRCULATIONAHA.106.678276 [pii]&#xD;10.1161/CIRCULATIONAHA.106.678276</electronic-resource-num><language>eng</language></record></Cite></EndNote>�D<EndNote><Cite><Author>Sowa</Author><Year>2002</Year><RecNum>30</RecNum><DisplayText>[21, 22]</DisplayText><record><rec-number>30</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">30</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sowa, H.</author><author>Kaji, H.</author><author>Yamaguchi, T.</author><author>Sugimoto, T.</author><author>Chihara, K.</author></authors></contributors><auth-address>Third Department of Medicine, Kobe University School of Medicine, Japan.</auth-address><titles><title>Smad3 promotes alkaline phosphatase activity and mineralization of osteoblastic MC3T3-E1 cells</title><secondary-title>J Bone Miner Res</secondary-title><alt-title>Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</alt-title></titles><periodical><full-title>J Bone Miner Res</full-title><abbr-1>Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</abbr-1></periodical><alt-periodical><full-title>J Bone Miner Res</full-title><abbr-1>Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</abbr-1></alt-periodical><pages>1190-9</pages><volume>17</volume><number>7</number><keywords><keyword>Alkaline Phosphatase/*metabolism</keyword><keyword>Animals</keyword><keyword>*Calcification, Physiologic</keyword><keyword>Calcium-Binding Proteins/metabolism</keyword><keyword>Cell Division</keyword><keyword>Cell Line</keyword><keyword>Cell Size</keyword><keyword>Collagen Type I/antagonists &amp; inhibitors/metabolism</keyword><keyword>DNA-Binding Proteins/genetics/*physiology</keyword><keyword>*Extracellular Matrix Proteins</keyword><keyword>Humans</keyword><keyword>Mice</keyword><keyword>Osteoblasts/cytology/metabolism/*physiology</keyword><keyword>Osteocalcin/metabolism</keyword><keyword>Osteopontin</keyword><keyword>Rats</keyword><keyword>Recombinant Fusion Proteins/genetics/physiology</keyword><keyword>Sialoglycoproteins/metabolism</keyword><keyword>*Signal Transduction</keyword><keyword>Smad3 Protein</keyword><keyword>Trans-Activators/genetics/*physiology</keyword><keyword>Transfection</keyword><keyword>Transforming Growth Factor beta/*physiology</keyword></keywords><dates><year>2002</year><pub-dates><date>Jul</date></pub-dates></dates><isbn>0884-0431 (Print)&#xD;0884-0431 (Linking)</isbn><accession-num>12096832</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/12096832</url></related-urls></urls><electronic-resource-num>10.1359/jbmr.2002.17.7.1190</electronic-resource-num></record></Cite><Cite><Author>Ralston</Author><Year>1995</Year><RecNum>32</RecNum><record><rec-number>32</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">32</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ralston, S. H.</author><author>Ho, L. P.</author><author>Helfrich, M. H.</author><author>Grabowski, P. S.</author><author>Johnston, P. W.</author><author>Benjamin, N.</author></authors></contributors><auth-address>Department of Medicine &amp; Therapeutics, University of Aberdeen Medical School, Foresterhill, U.K.</auth-address><titles><title>Nitric oxide: a cytokine-induced regulator of bone resorption</title><secondary-title>J Bone Miner Res</secondary-title><alt-title>Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</alt-title></titles><periodical><full-title>J Bone Miner Res</full-title><abbr-1>Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</abbr-1></periodical><alt-periodical><full-title>J Bone Miner Res</full-title><abbr-1>Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</abbr-1></alt-periodical><pages>1040-9</pages><volume>10</volume><number>7</number><keywords><keyword>Animals</keyword><keyword>Arginine/analogs &amp; derivatives/pharmacology/therapeutic use</keyword><keyword>Base Sequence</keyword><keyword>Bone Resorption/drug therapy/genetics/*physiopathology</keyword><keyword>Calcium/metabolism</keyword><keyword>Cytokines/*pharmacology/therapeutic use</keyword><keyword>DNA Primers/chemistry</keyword><keyword>Dinoprostone/metabolism</keyword><keyword>Drug Synergism</keyword><keyword>Enzyme Inhibitors/pharmacology/therapeutic use</keyword><keyword>Humans</keyword><keyword>Interferon-gamma/pharmacology/therapeutic use</keyword><keyword>Interleukin-1/pharmacology/therapeutic use</keyword><keyword>Mice</keyword><keyword>Molecular Sequence Data</keyword><keyword>Nitric Oxide/biosynthesis/*physiology</keyword><keyword>Nitric Oxide Synthase/antagonists &amp; inhibitors/genetics</keyword><keyword>Organ Culture Techniques</keyword><keyword>Osteoclasts/cytology/*drug effects</keyword><keyword>Penicillamine/analogs &amp; derivatives/pharmacology/therapeutic use</keyword><keyword>Polymerase Chain Reaction</keyword><keyword>RNA/analysis/metabolism</keyword><keyword>Recombinant Proteins/pharmacology/therapeutic use</keyword><keyword>S-Nitroso-N-Acetylpenicillamine</keyword><keyword>Tumor Necrosis Factor-alpha/pharmacology/therapeutic use</keyword><keyword>omega-N-Methylarginine</keyword></keywords><dates><year>1995</year><pub-dates><date>Jul</date></pub-dates></dates><isbn>0884-0431 (Print)&#xD;0884-0431 (Linking)</isbn><accession-num>7484279</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/7484279</url></related-urls></urls><electronic-resource-num>10.1002/jbmr.5650100708</electronic-resource-num></record></Cite></EndNote>�D<EndNote><Cite><Author>Sowa</Author><Year>2002</Year><RecNum>30</RecNum><DisplayText>[21, 22]</DisplayText><record><rec-number>30</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">30</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sowa, H.</author><author>Kaji, H.</author><author>Yamaguchi, T.</author><author>Sugimoto, T.</author><author>Chihara, K.</author></authors></contributors><auth-address>Third Department of Medicine, Kobe University School of Medicine, Japan.</auth-address><titles><title>Smad3 promotes alkaline phosphatase activity and mineralization of osteoblastic MC3T3-E1 cells</title><secondary-title>J Bone Miner Res</secondary-title><alt-title>Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</alt-title></titles><periodical><full-title>J Bone Miner Res</full-title><abbr-1>Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</abbr-1></periodical><alt-periodical><full-title>J Bone Miner Res</full-title><abbr-1>Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</abbr-1></alt-periodical><pages>1190-9</pages><volume>17</volume><number>7</number><keywords><keyword>Alkaline Phosphatase/*metabolism</keyword><keyword>Animals</keyword><keyword>*Calcification, Physiologic</keyword><keyword>Calcium-Binding Proteins/metabolism</keyword><keyword>Cell Division</keyword><keyword>Cell Line</keyword><keyword>Cell Size</keyword><keyword>Collagen Type I/antagonists &amp; inhibitors/metabolism</keyword><keyword>DNA-Binding Proteins/genetics/*physiology</keyword><keyword>*Extracellular Matrix Proteins</keyword><keyword>Humans</keyword><keyword>Mice</keyword><keyword>Osteoblasts/cytology/metabolism/*physiology</keyword><keyword>Osteocalcin/metabolism</keyword><keyword>Osteopontin</keyword><keyword>Rats</keyword><keyword>Recombinant Fusion Proteins/genetics/physiology</keyword><keyword>Sialoglycoproteins/metabolism</keyword><keyword>*Signal Transduction</keyword><keyword>Smad3 Protein</keyword><keyword>Trans-Activators/genetics/*physiology</keyword><keyword>Transfection</keyword><keyword>Transforming Growth Factor beta/*physiology</keyword></keywords><dates><year>2002</year><pub-dates><date>Jul</date></pub-dates></dates><isbn>0884-0431 (Print)&#xD;0884-0431 (Linking)</isbn><accession-num>12096832</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/12096832</url></related-urls></urls><electronic-resource-num>10.1359/jbmr.2002.17.7.1190</electronic-resource-num></record></Cite><Cite><Author>Ralston</Author><Year>1995</Year><RecNum>32</RecNum><record><rec-number>32</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">32</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ralston, S. H.</author><author>Ho, L. P.</author><author>Helfrich, M. H.</author><author>Grabowski, P. S.</author><author>Johnston, P. W.</author><author>Benjamin, N.</author></authors></contributors><auth-address>Department of Medicine &amp; Therapeutics, University of Aberdeen Medical School, Foresterhill, U.K.</auth-address><titles><title>Nitric oxide: a cytokine-induced regulator of bone resorption</title><secondary-title>J Bone Miner Res</secondary-title><alt-title>Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</alt-title></titles><periodical><full-title>J Bone Miner Res</full-title><abbr-1>Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</abbr-1></periodical><alt-periodical><full-title>J Bone Miner Res</full-title><abbr-1>Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</abbr-1></alt-periodical><pages>1040-9</pages><volume>10</volume><number>7</number><keywords><keyword>Animals</keyword><keyword>Arginine/analogs &amp; derivatives/pharmacology/therapeutic use</keyword><keyword>Base Sequence</keyword><keyword>Bone Resorption/drug therapy/genetics/*physiopathology</keyword><keyword>Calcium/metabolism</keyword><keyword>Cytokines/*pharmacology/therapeutic use</keyword><keyword>DNA Primers/chemistry</keyword><keyword>Dinoprostone/metabolism</keyword><keyword>Drug Synergism</keyword><keyword>Enzyme Inhibitors/pharmacology/therapeutic use</keyword><keyword>Humans</keyword><keyword>Interferon-gamma/pharmacology/therapeutic use</keyword><keyword>Interleukin-1/pharmacology/therapeutic use</keyword><keyword>Mice</keyword><keyword>Molecular Sequence Data</keyword><keyword>Nitric Oxide/biosynthesis/*physiology</keyword><keyword>Nitric Oxide Synthase/antagonists &amp; inhibitors/genetics</keyword><keyword>Organ Culture Techniques</keyword><keyword>Osteoclasts/cytology/*drug effects</keyword><keyword>Penicillamine/analogs &amp; derivatives/pharmacology/therapeutic use</keyword><keyword>Polymerase Chain Reaction</keyword><keyword>RNA/analysis/metabolism</keyword><keyword>Recombinant Proteins/pharmacology/therapeutic use</keyword><keyword>S-Nitroso-N-Acetylpenicillamine</keyword><keyword>Tumor Necrosis Factor-alpha/pharmacology/therapeutic use</keyword><keyword>omega-N-Methylarginine</keyword></keywords><dates><year>1995</year><pub-dates><date>Jul</date></pub-dates></dates><isbn>0884-0431 (Print)&#xD;0884-0431 (Linking)</isbn><accession-num>7484279</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/7484279</url></related-urls></urls><electronic-resource-num>10.1002/jbmr.5650100708</electronic-resource-num></record></Cite></EndNote>�
D<EndNote><Cite><Author>Sowa</Author><Year>2002</Year><RecNum>30</RecNum><DisplayText>[21]</DisplayText><record><rec-number>30</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">30</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sowa, H.</author><author>Kaji, H.</author><author>Yamaguchi, T.</author><author>Sugimoto, T.</author><author>Chihara, K.</author></authors></contributors><auth-address>Third Department of Medicine, Kobe University School of Medicine, Japan.</auth-address><titles><title>Smad3 promotes alkaline phosphatase activity and mineralization of osteoblastic MC3T3-E1 cells</title><secondary-title>J Bone Miner Res</secondary-title><alt-title>Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</alt-title></titles><periodical><full-title>J Bone Miner Res</full-title><abbr-1>Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</abbr-1></periodical><alt-periodical><full-title>J Bone Miner Res</full-title><abbr-1>Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</abbr-1></alt-periodical><pages>1190-9</pages><volume>17</volume><number>7</number><keywords><keyword>Alkaline Phosphatase/*metabolism</keyword><keyword>Animals</keyword><keyword>*Calcification, Physiologic</keyword><keyword>Calcium-Binding Proteins/metabolism</keyword><keyword>Cell Division</keyword><keyword>Cell Line</keyword><keyword>Cell Size</keyword><keyword>Collagen Type I/antagonists &amp; inhibitors/metabolism</keyword><keyword>DNA-Binding Proteins/genetics/*physiology</keyword><keyword>*Extracellular Matrix Proteins</keyword><keyword>Humans</keyword><keyword>Mice</keyword><keyword>Osteoblasts/cytology/metabolism/*physiology</keyword><keyword>Osteocalcin/metabolism</keyword><keyword>Osteopontin</keyword><keyword>Rats</keyword><keyword>Recombinant Fusion Proteins/genetics/physiology</keyword><keyword>Sialoglycoproteins/metabolism</keyword><keyword>*Signal Transduction</keyword><keyword>Smad3 Protein</keyword><keyword>Trans-Activators/genetics/*physiology</keyword><keyword>Transfection</keyword><keyword>Transforming Growth Factor beta/*physiology</keyword></keywords><dates><year>2002</year><pub-dates><date>Jul</date></pub-dates></dates><isbn>0884-0431 (Print)&#xD;0884-0431 (Linking)</isbn><accession-num>12096832</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/12096832</url></related-urls></urls><electronic-resource-num>10.1359/jbmr.2002.17.7.1190</electronic-resource-num></record></Cite></EndNote>�
D<EndNote><Cite><Author>Sowa</Author><Year>2002</Year><RecNum>30</RecNum><DisplayText>[21]</DisplayText><record><rec-number>30</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">30</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sowa, H.</author><author>Kaji, H.</author><author>Yamaguchi, T.</author><author>Sugimoto, T.</author><author>Chihara, K.</author></authors></contributors><auth-address>Third Department of Medicine, Kobe University School of Medicine, Japan.</auth-address><titles><title>Smad3 promotes alkaline phosphatase activity and mineralization of osteoblastic MC3T3-E1 cells</title><secondary-title>J Bone Miner Res</secondary-title><alt-title>Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</alt-title></titles><periodical><full-title>J Bone Miner Res</full-title><abbr-1>Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</abbr-1></periodical><alt-periodical><full-title>J Bone Miner Res</full-title><abbr-1>Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</abbr-1></alt-periodical><pages>1190-9</pages><volume>17</volume><number>7</number><keywords><keyword>Alkaline Phosphatase/*metabolism</keyword><keyword>Animals</keyword><keyword>*Calcification, Physiologic</keyword><keyword>Calcium-Binding Proteins/metabolism</keyword><keyword>Cell Division</keyword><keyword>Cell Line</keyword><keyword>Cell Size</keyword><keyword>Collagen Type I/antagonists &amp; inhibitors/metabolism</keyword><keyword>DNA-Binding Proteins/genetics/*physiology</keyword><keyword>*Extracellular Matrix Proteins</keyword><keyword>Humans</keyword><keyword>Mice</keyword><keyword>Osteoblasts/cytology/metabolism/*physiology</keyword><keyword>Osteocalcin/metabolism</keyword><keyword>Osteopontin</keyword><keyword>Rats</keyword><keyword>Recombinant Fusion Proteins/genetics/physiology</keyword><keyword>Sialoglycoproteins/metabolism</keyword><keyword>*Signal Transduction</keyword><keyword>Smad3 Protein</keyword><keyword>Trans-Activators/genetics/*physiology</keyword><keyword>Transfection</keyword><keyword>Transforming Growth Factor beta/*physiology</keyword></keywords><dates><year>2002</year><pub-dates><date>Jul</date></pub-dates></dates><isbn>0884-0431 (Print)&#xD;0884-0431 (Linking)</isbn><accession-num>12096832</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/12096832</url></related-urls></urls><electronic-resource-num>10.1359/jbmr.2002.17.7.1190</electronic-resource-num></record></Cite></EndNote>ZD<EndNote><Cite><Author>Yamaguchi</Author><Year>2002</Year><RecNum>26</RecNum><DisplayText>[23]</DisplayText><record><rec-number>26</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">26</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Yamaguchi, T.</author><author>Sugimoto, T.</author><author>Yano, S.</author><author>Yamauchi, M.</author><author>Sowa, H.</author><author>Chen, Q.</author><author>Chihara, K.</author></authors></contributors><auth-address>Division of Endocrinology/Metabolism, Neurology and Hematology/Oncology, Kobe University Postgraduate School of Medicine, Japan.</auth-address><titles><title>Plasma lipids and osteoporosis in postmenopausal women</title><secondary-title>Endocr J</secondary-title><alt-title>Endocrine journal</alt-title></titles><periodical><full-title>Endocr J</full-title><abbr-1>Endocrine journal</abbr-1></periodical><alt-periodical><full-title>Endocr J</full-title><abbr-1>Endocrine journal</abbr-1></alt-periodical><pages>211-7</pages><volume>49</volume><number>2</number><keywords><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Bone Density/physiology</keyword><keyword>Cholesterol/blood</keyword><keyword>Cholesterol, HDL/blood</keyword><keyword>Cholesterol, LDL/blood</keyword><keyword>Female</keyword><keyword>Femur/physiology</keyword><keyword>Humans</keyword><keyword>Lipids/*blood</keyword><keyword>Lumbar Vertebrae/physiology</keyword><keyword>Middle Aged</keyword><keyword>Multivariate Analysis</keyword><keyword>Osteoporosis, Postmenopausal/*blood</keyword><keyword>Radius/physiology</keyword><keyword>Regression Analysis</keyword><keyword>Spinal Fractures/pathology</keyword><keyword>Triglycerides/blood</keyword></keywords><dates><year>2002</year><pub-dates><date>Apr</date></pub-dates></dates><isbn>0918-8959 (Print)&#xD;0918-8959 (Linking)</isbn><accession-num>12081241</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/12081241</url></related-urls></urls></record></Cite></EndNote>ZD<EndNote><Cite><Author>Yamaguchi</Author><Year>2002</Year><RecNum>26</RecNum><DisplayText>[23]</DisplayText><record><rec-number>26</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">26</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Yamaguchi, T.</author><author>Sugimoto, T.</author><author>Yano, S.</author><author>Yamauchi, M.</author><author>Sowa, H.</author><author>Chen, Q.</author><author>Chihara, K.</author></authors></contributors><auth-address>Division of Endocrinology/Metabolism, Neurology and Hematology/Oncology, Kobe University Postgraduate School of Medicine, Japan.</auth-address><titles><title>Plasma lipids and osteoporosis in postmenopausal women</title><secondary-title>Endocr J</secondary-title><alt-title>Endocrine journal</alt-title></titles><periodical><full-title>Endocr J</full-title><abbr-1>Endocrine journal</abbr-1></periodical><alt-periodical><full-title>Endocr J</full-title><abbr-1>Endocrine journal</abbr-1></alt-periodical><pages>211-7</pages><volume>49</volume><number>2</number><keywords><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Bone Density/physiology</keyword><keyword>Cholesterol/blood</keyword><keyword>Cholesterol, HDL/blood</keyword><keyword>Cholesterol, LDL/blood</keyword><keyword>Female</keyword><keyword>Femur/physiology</keyword><keyword>Humans</keyword><keyword>Lipids/*blood</keyword><keyword>Lumbar Vertebrae/physiology</keyword><keyword>Middle Aged</keyword><keyword>Multivariate Analysis</keyword><keyword>Osteoporosis, Postmenopausal/*blood</keyword><keyword>Radius/physiology</keyword><keyword>Regression Analysis</keyword><keyword>Spinal Fractures/pathology</keyword><keyword>Triglycerides/blood</keyword></keywords><dates><year>2002</year><pub-dates><date>Apr</date></pub-dates></dates><isbn>0918-8959 (Print)&#xD;0918-8959 (Linking)</isbn><accession-num>12081241</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/12081241</url></related-urls></urls></record></Cite></EndNote>D<EndNote><Cite><Author>Ahmadi</Author><Year>2010</Year><RecNum>9</RecNum><DisplayText>[7]</DisplayText><record><rec-number>9</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">9</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ahmadi, N.</author><author>Tsimikas, S.</author><author>Hajsadeghi, F.</author><author>Saeed, A.</author><author>Nabavi, V.</author><author>Bevinal, M. A.</author><author>Kadakia, J.</author><author>Flores, F.</author><author>Ebrahimi, R.</author><author>Budoff, M. J.</author></authors></contributors><auth-address>Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, California, USA.</auth-address><titles><title>Relation of oxidative biomarkers, vascular dysfunction, and progression of coronary artery calcium</title><secondary-title>Am J Cardiol</secondary-title><alt-title>The American journal of cardiology</alt-title></titles><periodical><full-title>Am J Cardiol</full-title><abbr-1>The American journal of cardiology</abbr-1></periodical><alt-periodical><full-title>Am J Cardiol</full-title><abbr-1>The American journal of cardiology</abbr-1></alt-periodical><pages>459-66</pages><volume>105</volume><number>4</number><edition>2010/02/16</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Apolipoprotein B-100/blood</keyword><keyword>Autoantibodies/blood</keyword><keyword>Biological Markers/*blood</keyword><keyword>Calcinosis/*blood/drug therapy/*physiopathology/radiography</keyword><keyword>Calcium/blood</keyword><keyword>Coronary Artery Disease/*blood/drug therapy/*physiopathology/radiography</keyword><keyword>Dietary Supplements</keyword><keyword>Disease Progression</keyword><keyword>Double-Blind Method</keyword><keyword>Equipment Design</keyword><keyword>Female</keyword><keyword>Fingers/*blood supply</keyword><keyword>Follow-Up Studies</keyword><keyword>*Garlic</keyword><keyword>Humans</keyword><keyword>Immunoglobulin G/blood</keyword><keyword>Immunoglobulin M/blood</keyword><keyword>Lipoprotein(a)/blood</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Oxidative Stress/drug effects</keyword><keyword>Phospholipids/blood</keyword><keyword>Phytotherapy</keyword><keyword>Plant Extracts/therapeutic use</keyword><keyword>Predictive Value of Tests</keyword><keyword>Severity of Illness Index</keyword><keyword>*Skin Temperature</keyword><keyword>Thermography/methods</keyword><keyword>Treatment Outcome</keyword><keyword>Vitamin B Complex/therapeutic use</keyword></keywords><dates><year>2010</year><pub-dates><date>Feb 15</date></pub-dates></dates><isbn>1879-1913 (Electronic)&#xD;0002-9149 (Linking)</isbn><accession-num>20152239</accession-num><work-type>Randomized Controlled Trial</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/20152239</url></related-urls></urls><electronic-resource-num>10.1016/j.amjcard.2009.09.052</electronic-resource-num><language>eng</language></record></Cite></EndNote>D<EndNote><Cite><Author>Ahmadi</Author><Year>2010</Year><RecNum>9</RecNum><DisplayText>[7]</DisplayText><record><rec-number>9</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">9</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ahmadi, N.</author><author>Tsimikas, S.</author><author>Hajsadeghi, F.</author><author>Saeed, A.</author><author>Nabavi, V.</author><author>Bevinal, M. A.</author><author>Kadakia, J.</author><author>Flores, F.</author><author>Ebrahimi, R.</author><author>Budoff, M. J.</author></authors></contributors><auth-address>Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, California, USA.</auth-address><titles><title>Relation of oxidative biomarkers, vascular dysfunction, and progression of coronary artery calcium</title><secondary-title>Am J Cardiol</secondary-title><alt-title>The American journal of cardiology</alt-title></titles><periodical><full-title>Am J Cardiol</full-title><abbr-1>The American journal of cardiology</abbr-1></periodical><alt-periodical><full-title>Am J Cardiol</full-title><abbr-1>The American journal of cardiology</abbr-1></alt-periodical><pages>459-66</pages><volume>105</volume><number>4</number><edition>2010/02/16</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Apolipoprotein B-100/blood</keyword><keyword>Autoantibodies/blood</keyword><keyword>Biological Markers/*blood</keyword><keyword>Calcinosis/*blood/drug therapy/*physiopathology/radiography</keyword><keyword>Calcium/blood</keyword><keyword>Coronary Artery Disease/*blood/drug therapy/*physiopathology/radiography</keyword><keyword>Dietary Supplements</keyword><keyword>Disease Progression</keyword><keyword>Double-Blind Method</keyword><keyword>Equipment Design</keyword><keyword>Female</keyword><keyword>Fingers/*blood supply</keyword><keyword>Follow-Up Studies</keyword><keyword>*Garlic</keyword><keyword>Humans</keyword><keyword>Immunoglobulin G/blood</keyword><keyword>Immunoglobulin M/blood</keyword><keyword>Lipoprotein(a)/blood</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Oxidative Stress/drug effects</keyword><keyword>Phospholipids/blood</keyword><keyword>Phytotherapy</keyword><keyword>Plant Extracts/therapeutic use</keyword><keyword>Predictive Value of Tests</keyword><keyword>Severity of Illness Index</keyword><keyword>*Skin Temperature</keyword><keyword>Thermography/methods</keyword><keyword>Treatment Outcome</keyword><keyword>Vitamin B Complex/therapeutic use</keyword></keywords><dates><year>2010</year><pub-dates><date>Feb 15</date></pub-dates></dates><isbn>1879-1913 (Electronic)&#xD;0002-9149 (Linking)</isbn><accession-num>20152239</accession-num><work-type>Randomized Controlled Trial</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/20152239</url></related-urls></urls><electronic-resource-num>10.1016/j.amjcard.2009.09.052</electronic-resource-num><language>eng</language></record></Cite></EndNote>D<EndNote><Cite><Author>Fraley</Author><Year>2009</Year><RecNum>36</RecNum><DisplayText>[25]</DisplayText><record><rec-number>36</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">36</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Fraley, A. E.</author><author>Schwartz, G. G.</author><author>Olsson, A. G.</author><author>Kinlay, S.</author><author>Szarek, M.</author><author>Rifai, N.</author><author>Libby, P.</author><author>Ganz, P.</author><author>Witztum, J. L.</author><author>Tsimikas, S.</author></authors></contributors><auth-address>University of California San Diego, 92093-0682, USA.</auth-address><titles><title>Relationship of oxidized phospholipids and biomarkers of oxidized low-density lipoprotein with cardiovascular risk factors, inflammatory biomarkers, and effect of statin therapy in patients with acute coronary syndromes: Results from the MIRACL (Myocardial Ischemia Reduction With Aggressive Cholesterol Lowering) trial</title><secondary-title>J Am Coll Cardiol</secondary-title></titles><periodical><full-title>J Am Coll Cardiol</full-title></periodical><pages>2186-96</pages><volume>53</volume><number>23</number><edition>2009/06/06</edition><keywords><keyword>Acute Coronary Syndrome/*drug therapy/immunology/physiopathology</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Anticholesteremic Agents/*therapeutic use</keyword><keyword>Apolipoproteins B/chemistry/immunology/metabolism</keyword><keyword>Autoantibodies/analysis</keyword><keyword>Biological Markers/analysis</keyword><keyword>*Cholesterol, LDL/analysis/immunology/metabolism</keyword><keyword>Cohort Studies</keyword><keyword>Female</keyword><keyword>Heptanoic Acids/*therapeutic use</keyword><keyword>Humans</keyword><keyword>Immunoglobulin G/analysis</keyword><keyword>Immunoglobulin M/analysis</keyword><keyword>Inflammation/physiopathology</keyword><keyword>Lipoprotein(a)/analysis</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Oxidation-Reduction</keyword><keyword>*Phospholipids/analysis/metabolism</keyword><keyword>Pyrroles/*therapeutic use</keyword><keyword>*Reactive Oxygen Species</keyword><keyword>Risk Factors</keyword><keyword>Thromboembolism</keyword></keywords><dates><year>2009</year><pub-dates><date>Jun 9</date></pub-dates></dates><isbn>1558-3597 (Electronic)</isbn><accession-num>19497447</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=19497447</url></related-urls></urls><electronic-resource-num>S0735-1097(09)00928-0 [pii]&#xD;10.1016/j.jacc.2009.02.041</electronic-resource-num><language>eng</language></record></Cite></EndNote>D<EndNote><Cite><Author>Fraley</Author><Year>2009</Year><RecNum>36</RecNum><DisplayText>[25]</DisplayText><record><rec-number>36</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">36</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Fraley, A. E.</author><author>Schwartz, G. G.</author><author>Olsson, A. G.</author><author>Kinlay, S.</author><author>Szarek, M.</author><author>Rifai, N.</author><author>Libby, P.</author><author>Ganz, P.</author><author>Witztum, J. L.</author><author>Tsimikas, S.</author></authors></contributors><auth-address>University of California San Diego, 92093-0682, USA.</auth-address><titles><title>Relationship of oxidized phospholipids and biomarkers of oxidized low-density lipoprotein with cardiovascular risk factors, inflammatory biomarkers, and effect of statin therapy in patients with acute coronary syndromes: Results from the MIRACL (Myocardial Ischemia Reduction With Aggressive Cholesterol Lowering) trial</title><secondary-title>J Am Coll Cardiol</secondary-title></titles><periodical><full-title>J Am Coll Cardiol</full-title></periodical><pages>2186-96</pages><volume>53</volume><number>23</number><edition>2009/06/06</edition><keywords><keyword>Acute Coronary Syndrome/*drug therapy/immunology/physiopathology</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Anticholesteremic Agents/*therapeutic use</keyword><keyword>Apolipoproteins B/chemistry/immunology/metabolism</keyword><keyword>Autoantibodies/analysis</keyword><keyword>Biological Markers/analysis</keyword><keyword>*Cholesterol, LDL/analysis/immunology/metabolism</keyword><keyword>Cohort Studies</keyword><keyword>Female</keyword><keyword>Heptanoic Acids/*therapeutic use</keyword><keyword>Humans</keyword><keyword>Immunoglobulin G/analysis</keyword><keyword>Immunoglobulin M/analysis</keyword><keyword>Inflammation/physiopathology</keyword><keyword>Lipoprotein(a)/analysis</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Oxidation-Reduction</keyword><keyword>*Phospholipids/analysis/metabolism</keyword><keyword>Pyrroles/*therapeutic use</keyword><keyword>*Reactive Oxygen Species</keyword><keyword>Risk Factors</keyword><keyword>Thromboembolism</keyword></keywords><dates><year>2009</year><pub-dates><date>Jun 9</date></pub-dates></dates><isbn>1558-3597 (Electronic)</isbn><accession-num>19497447</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=19497447</url></related-urls></urls><electronic-resource-num>S0735-1097(09)00928-0 [pii]&#xD;10.1016/j.jacc.2009.02.041</electronic-resource-num><language>eng</language></record></Cite></EndNote>�	D<EndNote><Cite><Author>Sumino</Author><Year>2007</Year><RecNum>22</RecNum><DisplayText>[26]</DisplayText><record><rec-number>22</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">22</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sumino, H.</author><author>Ichikawa, S.</author><author>Kasama, S.</author><author>Takahashi, T.</author><author>Sakamoto, H.</author><author>Kumakura, H.</author><author>Takayama, Y.</author><author>Kanda, T.</author><author>Murakami, M.</author><author>Kurabayashi, M.</author></authors></contributors><auth-address>Department of Nursing, Faculty of Nursing, Takasaki University of Health and Welfare, Takasaki, Japan. hsumino@takasaki-u.ac.jp</auth-address><titles><title>Relationship between brachial arterial endothelial function and lumbar spine bone mineral density in postmenopausal women</title><secondary-title>Circ J</secondary-title><alt-title>Circulation journal : official journal of the Japanese Circulation Society</alt-title></titles><periodical><full-title>Circ J</full-title><abbr-1>Circulation journal : official journal of the Japanese Circulation Society</abbr-1></periodical><alt-periodical><full-title>Circ J</full-title><abbr-1>Circulation journal : official journal of the Japanese Circulation Society</abbr-1></alt-periodical><pages>1555-9</pages><volume>71</volume><number>10</number><keywords><keyword>Absorptiometry, Photon</keyword><keyword>Aged</keyword><keyword>Atherosclerosis/etiology/physiopathology</keyword><keyword>Bone Density/*physiology</keyword><keyword>Bone Diseases, Metabolic/complications/physiopathology</keyword><keyword>Brachial Artery/*physiology</keyword><keyword>Case-Control Studies</keyword><keyword>Endothelium, Vascular/*physiology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Lumbar Vertebrae/*physiology</keyword><keyword>Middle Aged</keyword><keyword>Osteoporosis, Postmenopausal/complications/physiopathology</keyword><keyword>Postmenopause/*physiology</keyword><keyword>Regression Analysis</keyword><keyword>Risk Factors</keyword><keyword>Vasodilation/physiology</keyword></keywords><dates><year>2007</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>1346-9843 (Print)&#xD;1346-9843 (Linking)</isbn><accession-num>17895551</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/17895551</url></related-urls></urls></record></Cite></EndNote>�	D<EndNote><Cite><Author>Sumino</Author><Year>2007</Year><RecNum>22</RecNum><DisplayText>[26]</DisplayText><record><rec-number>22</rec-number><foreign-keys><key app="EN" db-id="5ft05dfwvd20wqerdv2pw50ktd0vz2s0v5r9">22</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sumino, H.</author><author>Ichikawa, S.</author><author>Kasama, S.</author><author>Takahashi, T.</author><author>Sakamoto, H.</author><author>Kumakura, H.</author><author>Takayama, Y.</author><author>Kanda, T.</author><author>Murakami, M.</author><author>Kurabayashi, M.</author></authors></contributors><auth-address>Department of Nursing, Faculty of Nursing, Takasaki University of Health and Welfare, Takasaki, Japan. hsumino@takasaki-u.ac.jp</auth-address><titles><title>Relationship between brachial arterial endothelial function and lumbar spine bone mineral density in postmenopausal women</title><secondary-title>Circ J</secondary-title><alt-title>Circulation journal : official journal of the Japanese Circulation Society</alt-title></titles><periodical><full-title>Circ J</full-title><abbr-1>Circulation journal : official journal of the Japanese Circulation Society</abbr-1></periodical><alt-periodical><full-title>Circ J</full-title><abbr-1>Circulation journal : official journal of the Japanese Circulation Society</abbr-1></alt-periodical><pages>1555-9</pages><volume>71</volume><number>10</number><keywords><keyword>Absorptiometry, Photon</keyword><keyword>Aged</keyword><keyword>Atherosclerosis/etiology/physiopathology</keyword><keyword>Bone Density/*physiology</keyword><keyword>Bone Diseases, Metabolic/complications/physiopathology</keyword><keyword>Brachial Artery/*physiology</keyword><keyword>Case-Control Studies</keyword><keyword>Endothelium, Vascular/*physiology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Lumbar Vertebrae/*physiology</keyword><keyword>Middle Aged</keyword><keyword>Osteoporosis, Postmenopausal/complications/physiopathology</keyword><keyword>Postmenopause/*physiology</keyword><keyword>Regression Analysis</keyword><keyword>Risk Factors</keyword><keyword>Vasodilation/physiology</keyword></keywords><dates><year>2007</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>1346-9843 (Print)&#xD;1346-9843 (Linking)</isbn><accession-num>17895551</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/17895551</url></related-urls></urls></record></Cite></EndNote>+s���������666666666vvvvvvvvv666666>666666666666666666666666666�6666666666�666666666666hH6666666666666666666666666666666666666666666666666666666666666666�62����&6FVfv������2(��&6FVfv������&6FVfv������&6FVfv������&6FVfv������&6FVfv������&6FVfv��8X�V~�������� 0@�� 0@�� 0@�� 0@�� 0@�� 0@�� 0@�� 0@�� 0@�� 0@�� 0@�� 0@�� 0@�� 0@$OJPJQJ^J_HmH	nH	sH	tH	J`�Jn�Normald��CJ_HaJmH	sH	tH	b@b$v?g�	Heading 2$$�(�@&!B*CJOJPJQJ^JaJph6_�d2d+o_�	Heading 3d��d�d@&[$\$5�CJOJPJQJ\�^JaJDA`�D
Default Paragraph FontRi�R
0Table Normal�4�
l4�a�(k �(
0No ListR��R	lS�0Balloon Textd��CJOJQJ^JaJN�/�NlS�0Balloon Text CharCJOJQJ^JaJ>@>lS�0Headerd���H�$.��!.lS�0Header Char> @2>lS�0Footerd���H�$.��A.lS�0Footer Charb�RblS� List Paragraphd��^��m$CJOJPJQJ^JaJ6U`�a6�0	Hyperlink>*B*ph��O�qYc�h2h�o�h�#XDefault1$7$8$H$1B*CJOJPJQJ^J_HaJmH	phsH	tH	`^@�`�Z0Normal (Web)d��d�d[$\$CJOJPJQJ^JaJB�o�B�oAapple-converted-space*�o�*�oA	highlightRZ@�R?�
Plain Textd��CJOJPJQJ^JaJF�/��F?�Plain Text CharOJPJQJ^J8�o��8�Oapple-style-spanR�/��R+o_�Heading 3 Char5�CJOJPJQJ\�^JaJ.X �.+o_@Emphasis6�]�$�O�$,vvk_ans.(�!.	�470Line Number*W �1*v?g`Strong5�\�V�/�AVv?g�Heading 2 Char!B*CJOJPJQJ^JaJph6_�D� �RD�P<0Revision%CJ_HaJmH	sH	tH	d�bd'sV�EndNote Bibliography Title	&�a$mHnHuj�/�qj&sV�EndNote Bibliography Title CharCJaJmHnHuZ�O�Z)sV�EndNote Bibliography(d�a$mHnHu^�/�^(sV�EndNote Bibliography CharCJaJmHnHuH�`�H�
�
No Spacing*CJ_HaJmH	sH	tH	PK!����[Content_Types].xml���N�0E�H���-J��@%�ǎǢ|�ș$�ز�U��L�TB� l,�3��;�r��Ø��J��B+$�G]��7O٭V��<a���(7��I��R�{�pgL�=��r���8�5v&����uQ�뉑8��C����X=��$␴�?6N�JC������F�B.ʹ'�.�+���Y�T���^e5�5�� ��ð�_�g -�;�����Yl�ݎ��|6^�N��`�?���[��PK!�֧�6_rels/.rels���j�0���}Q��%v/��C/�}�(h"���O�
����=������ ����C?�h�v=��Ʌ��%[xp��{۵_�Pѣ<�1�H�0���O�R�Bd���JE�4b$��q_����6L�R�7`������0̞O��,�En7�Li�b��/�S���e��е�����PK!ky���theme/theme/themeManager.xml�M
� @�}�w��7c�(Eb�ˮ��C�AǠҟ����7��՛K
Y,�
�e�.���|,���H�,l����xɴ��I�sQ}#Ր���� ֵ+�!�,�^�$j=�GW��)�E�+&
8���PK!�R%���theme/theme/theme1.xml�Y]��F}/�?�;�����l�ζ�MB��ql��Ɏ4F3ލ	��<
�i�C}�CiH�/��6�M!�wF�<c���%��d
�4:�Ι{��I��܏�s�NX�p��
���!�x�po�����p���,�
w��{e��.��;`��pC!�;�<�0���pm̒	8M&�Q���oD�B����]'F��1�!v�ҥ��tޡp.�4�I�ذP��aQ"��4q�m�0ψ��}�:qnA�����y��0�b��f�U���谤�L&�lR��J3�Tl�:�N�S�)a�)ݧߪ�����C��v�].x�y�sӗ?�@�o��E�@)��{^�x^�R|e_-4�^�+PHI|��.��r�\m3�g��}�[--��PP
Yu�)�,�j-B�X��R$H����8@���I�7E1�0\(��2��?O����4k���!���ÄLE������߼|�<zq�藓ǏO��:2��P<ѭ^���O?u�z���'_��\���g����+]�����x���7���������s�:>vn��B`2ǃ��,�!"�E3�p#9��G���Qd����;	H�
xuv� ��� ����0F[,�F᚜KsO�'3w�#�����vfS�Vbs�ؠy��X�	��p�5v��euw	1�z@�	�l,���i!b
I��jZ��2��|�9�������L$��Z�15�x��l.�(�z���m${�d��:\@�'�2�3œ�ln$�^-��@^�i?���D&��|�#�td�!��6l�ġ���B�"�&6�3�yy@��t�!�H��jp�U��*ye�Xry3�~{s:FXI
����O�5Y��[Y!}��S˪.��7b����d|n]�������6��71�.�
�t��n�/����w/�+���[�t��6���}��P�s���ںs�L�.J;�̊��i��N�	�$A��I������)�t2���L�m����x:��(}\-�i*��x����QC��Ju���Wl'�QyI@ھ
	m2�D�B���AR�4	��w¢naQ��`Բ���Ɂ
W�=0#x�B�d��T/����.3�-�F�>bY�L�%׭˓�KK��6Hh�f�P�Q=��h��)G�B�ms]_�Ԡ'C���ZѨ���ys
v��@c])h�7�Jه��i��c?FS�.���N���P$�
e�&\�Ӏ+�I� "'%QÕ���@c�!�[��pa��AV.9H��d<��Ӯ��H����VX�*��%�A�{����YrA��բ�px�SL�9"�:3�U��5�����U
��NC��(���p%�u��@;[���d��`���4�)��]�t#9M4W=�P�5�*f̰lk�<_��X-C��w�T��%��Ժ�}B�% �Y�,]�
A���̠&oʰ��Ũ�;�<��Y������۵�e=�:����z���x��T�V�=�Olpģ
/�gTp�J�� ��Ԟ$�
�E�ŭG�,!
�A�ozA�r����ye�����r���b�/ڭ�Ch,"��~�ͥ���|��E�o|}��o�.
Y�g��J^W__���__��R���V%W/7�9�ݪ��A��kW�j���Z���u��k��ҩ�*� �y���_��^����Z�k>\lc`�|,b�U�v���PK!
ѐ��'theme/theme/_rels/themeManager.xml.rels��M
�0���wooӺ�&݈Э���5
6?$Q��
�,.�a��i����c2�1h�:�q��m��@RN��;d�`��o7�g�K(M&$R(.1�r'J��ЊT���8��V�"��AȻ�H�u}��|�$�b{��P����8�g/]�QAsم(����#��L�[������PK-!����[Content_Types].xmlPK-!�֧�60_rels/.relsPK-!ky���theme/theme/themeManager.xmlPK-!�R%����theme/theme/theme1.xmlPK-!
ѐ��'�	theme/theme/_rels/themeManager.xml.relsPK]�
<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<a:clrMap xmlns:a="http://schemas.openxmlformats.org/drawingml/2006/main" bg1="lt1" tx1="dk1" bg2="lt2" tx2="dk2" accent1="accent1" accent2="accent2" accent3="accent3" accent4="accent4" accent5="accent5" accent6="accent6" hlink="hlink" folHlink="folHlink"/>�|��2(����2D(����	55=======@�	�	�
�

	�*�K�v:�]�� � �!7"�'�)�*�.�1M407�7�9�:Q<�=�?�@ IIDJVK$LuST'U�UX�XjZ�Z�b�cZd�e8fOg
v���g�	�s�����MOPQRTUVWXYZ[\]^_`abcdfghijklmnopqstuvwxyz{|}~������������������
��9ۄZ�|���NSer���Y��Ns���EGIiy�������CEprt 68:jln2BXZ\����������������	8:<�������   3 5 7 �"�"�"�"�"�"�"�"C'd'p'�'�'�'4G4H4H5X5n5p5r5�5�5�5�5�5�5�6�6�6�6�6(7+7.7b7e7g7h7�7�7�8@@Q@T@V@X@h@~@�@�@�@�@�@DATAjAlAnA�A�A�A0B@BVBXBZB�B�B�B�B�B�BUC�I�IJJ!J�J�J�J�J�JKK
KLL(L*L,L]L`LbLOO1O3O5OdOgOjO�O�O�O�O�O�O�OPPP;P<PQ Q6Q8Q:QiQlQnQ�Q�Q�Q�Q�Q)R,R.R�R�Y�Y�Y�Y�Y�Z[%['[)[X[Z[\[�\�\�\�\]2]5]7](^8^N^P^R^�^�^�^�^cfef�f�f�f�f�m�m�m�m�m�m�u�u
vvvlz�z�z�|}z���X���X���QQ�D��X��̕�QQ�D��X��̕�Q��X��̕�QQ�D��X��̕�QQ�D��X��̕�X���QQ�D��X��̕�QQ�D��X��̕�QQ�D��X��̕�QQ�D��X��̕�QQ�D��X��̕�X���X���X���QQ�D��X��̕�X���QQ�D��X���X��̕�X���Q��X��̕�QQ�D��X��̕�QQ�D��X��̕�QQ�D��X���X��̕�Q��X��̕�QQ�D��X��̕�QQ�D��X��̕�QQ�D��X���X��̕�X���X���X���QQ�D��X��̕�QQ�D��X��̕�Q��X��̕�QQ�D��X��̕�QQ�D��X��̕�QQ�D��X��̕�Q��X��̕�Q��X��̕�Q��X��̕�X���Q����)/@!�����T� #����@���������H ��0�(	�
����0�(	�
��B
�S����	?��� bbib15sec9ack0010_ENREF_1_ENREF_2_ENREF_3_ENREF_4_ENREF_5_ENREF_6_ENREF_7_ENREF_8_ENREF_9	_ENREF_10	_ENREF_11	_ENREF_12	_ENREF_13	_ENREF_14	_ENREF_15	_ENREF_16	_ENREF_17	_ENREF_18	_ENREF_19	_ENREF_20	_ENREF_21	_ENREF_22	_ENREF_23	_ENREF_24	_ENREF_25	_ENREF_26	_ENREF_27	_ENREF_28	_ENREF_29��{�{}�}�~C���N��s�Z�ۃW�+�Ņ��*���k����P��t��Y����6����	

��{�{�}�~B���M��r�Y�ڃV�*�ą��)���j����N��s��X����5��z���|�~������������������|�~������������������DY���������	�	�
�
�y� 7BY������ �"�"�2�2T3T3�3�3X5o5�6�6h@@TAkA@BWB�J�JL)LO2O Q7Q�Q�Q[&[�\�\8^O^�y�y�y�y�y�zE{E{�{�{V|V|�|�|�|{�|������������
J�v����������D�R����������?>����v���������>�������������w�!��{���������n4G"�v���������dm�,0����������D}x.,;����������Q�3:)L���������g0�G�v���������C�L�\���������kQ�v�����������T��nv���������$i�Z�\�����������a�.p?����������[d�&`���������/j�n�v���������f{tޏ�r���������BzyTJ���������������^��`���o(.������^��`���.��p�L�^�p`�L�.��@���^�@`���.�����^�`���.����L�^��`�L�.������^��`���.������^��`���.��P�L�^�P`�L�.�������^��`���.��������^��`���.��p����p^�p`���.��@����@^�@`���.������^�`���.��������^��`���.��������^��`���.��������^��`���.��P����P^�P`���.�������^��`���OJQJo(����������^��`���OJQJo(����p����p^�p`���OJQJo(����@����@^�@`���OJQJo(��������^�`���OJQJo(����������^��`���OJQJo(����������^��`���OJQJo(����������^��`���OJQJo(����P����P^�P`���OJQJo(���������^��`���OJQJo(����������^��`���OJQJo(����p����p^�p`���OJQJo(����@����@^�@`���OJQJo(��������^�`���OJQJo(����������^��`���OJQJo(����������^��`���OJQJo(����������^��`���OJQJo(����P����P^�P`���OJQJo(���������^��`���)��������^��`���)��p����p^�p`���)��@����@^�@`���)������^�`���)��������^��`���)��������^��`���)��������^��`���)��P����P^�P`���)�����^��`���o(.������^��`���.��p�L�^�p`�L�.��@���^�@`���.�����^�`���.����L�^��`�L�.������^��`���.������^��`���.��P�L�^�P`�L�.�����^��`���OJ	PJQJ	^J
o(��������^��`���OJQJ^Jo(o��p���^�p`���OJ	QJ	o(����@���^�@`���OJQJo(�������^�`���OJQJ^Jo(o������^��`���OJ	QJ	o(��������^��`���OJQJo(��������^��`���OJQJ^Jo(o��P���^�P`���OJ	QJ	o(���������^��`���OJQJo(����������^��`���OJQJo(����p����p^�p`���OJQJo(����@����@^�@`���OJQJo(��������^�`���OJQJo(����������^��`���OJQJo(����������^��`���OJQJo(����������^��`���OJQJo(����P����P^�P`���OJQJo(���������^��`���OJQJo(����������^��`���OJQJo(����p����p^�p`���OJQJo(����@����@^�@`���OJQJo(��������^�`���OJQJo(����������^��`���OJQJo(����������^��`���OJQJo(����������^��`���OJQJo(����P����P^�P`���OJQJo(�������^��`���o(.������^��`���.��p�L�^�p`�L�.��@���^�@`���.�����^�`���.����L�^��`�L�.������^��`���.������^��`���.��P�L�^�P`�L�.�������^��`���OJQJo(����������^��`���OJQJo(����p����p^�p`���OJQJo(����@����@^�@`���OJQJo(��������^�`���OJQJo(����������^��`���OJQJo(����������^��`���OJQJo(����������^��`���OJQJo(����P����P^�P`���OJQJo(�������^��`���o(.������^��`���.��p�L�^�p`�L�.��@���^�@`���.�����^�`���.����L�^��`�L�.������^��`���.������^��`���.��P�L�^�P`�L�.�������^��`���)��������^��`���)��p����p^�p`���)��@����@^�@`���)������^�`���)��������^��`���)��������^��`���)��������^��`���)��P����P^�P`���)�������^��`���OJQJo(����������^��`���OJQJo(����p����p^�p`���OJQJo(����@����@^�@`���OJQJo(��������^�`���OJQJo(����������^��`���OJQJo(����������^��`���OJQJo(����������^��`���OJQJo(����P����P^�P`���OJQJo(���������^��`���)��������^��`���)��p����p^�p`���)��@����@^�@`���)������^�`���)��������^��`���)��������^��`���)��������^��`���)��P����P^�P`���)�����^��`���OJ	PJQJ	^J
o(��������^��`���OJQJ^Jo(o��p���^�p`���OJ	QJ	o(����@���^�@`���OJQJo(�������^�`���OJQJ^Jo(o������^��`���OJ	QJ	o(��������^��`���OJQJo(��������^��`���OJQJ^Jo(o��P���^�P`���OJ	QJ	o(�������^��`���o(.������^��`���.��p�L�^�p`�L�.��@���^�@`���.�����^�`���.����L�^��`�L�.������^��`���.������^��`���.��P�L�^�P`�L�. �����^��`���B*CJOJ	PJQJ	^Jo(ph��������^��`���OJQJ^Jo(o��p���^�p`���OJ	QJ	o(����@���^�@`���OJQJo(�������^�`���OJQJ^Jo(o������^��`���OJ	QJ	o(��������^��`���OJQJo(��������^��`���OJQJ^Jo(o��P���^�P`���OJ	QJ	o(���������^��`���OJQJo(" ��������^��`���OJQJo(" ��p����p^�p`���OJQJo(" ��@����@^�@`���OJQJo(" ������^�`���OJQJo(" ��������^��`���OJQJo(" ��������^��`���OJQJo(" ��������^��`���OJQJo(" ��PSummaryInformation(�����DocumentSummaryInformation8������������pMsoDataStore
`�S������V����G�B��5�Q�UO���J�QQN�MA==2��������`�S������V��������	

 !"#$%&'()*+,-./0123456789:;<=>?@����BCD����FGHIJ����L��������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������Oh��+'��0`�������	��
(
4@HPX�vlarijaniNormalNASER AHMADI2Microsoft Office Word@F�#@������@��������z����՜.��+,��D��՜.��+,��8�hp��������
���Veteran AffairsI3�Title8
 8@_PID_HLINKS�A�@
_ENREF_12C
_ENREF_29C�
_ENREF_28C�
_ENREF_27C�
_ENREF_26C�
_ENREF_25F�	_ENREF_7C�
_ENREF_24C�
_ENREF_23C�
_ENREF_21B�
_ENREF_36B�
_ENREF_36B�
_ENREF_36C�
_ENREF_22C�
_ENREF_21C�
_ENREF_20@�
_ENREF_19@�
_ENREF_13@�
_ENREF_18@�
_ENREF_17@�
_ENREF_16@�
_ENREF_15@{
_ENREF_14@v
_ENREF_17@r
_ENREF_13@o
_ENREF_12@h
_ENREF_17@d
_ENREF_11@]
_ENREF_12VZhttp://www.stata.com/p%Whttp://www.sas.com/@S
_ENREF_10HK	_ENREF_9IC	_ENREF_8F;	_ENREF_7D3	_ENREF_5F,	_ENREF_7E(	_ENREF_4E 	_ENREF_4B	_ENREF_3C	_ENREF_2@
	_ENREF_1yXmailto:ahmadi@ucla.edu!2,http://www.ncbi.nlm.nih.gov/pubmed/20152239<b:Sources SelectedStyle="\APASixthEditionOfficeOnline.xsl" StyleName="APA" Version="6" xmlns:b="http://schemas.openxmlformats.org/officeDocument/2006/bibliography" xmlns="http://schemas.openxmlformats.org/officeDocument/2006/bibliography"></b:Sources>
<?xml version="1.0" encoding="UTF-8" standalone="no"?>
<ds:datastoreItem ds:itemID="{E17EC01A-50FA-43E9-B09B-C26F41036B30}" xmlns:ds="http://schemas.openxmlformats.org/officeDocument/2006/cusItem
����	����A�Properties������������EUCompObj������������Kr������������tomXml"><ds:schemaRefs><ds:schemaRef ds:uri="http://schemas.openxmlformats.org/officeDocument/2006/bibliography"/></ds:schemaRefs></ds:datastoreItem>��
����	�F Microsoft Word 97-2003 Document
MSWordDocWord.Document.8�9�q����P^�P`���OJQJo(" C�LBzyQ�3$i�Z?>�D}x.>���Tw�!��af{t�[ddm�,�D�n4G"�
Jg0�G/j�nkQ��������������������������������������������������������������������������������									&Fh5�縆2>��5l_8�$��+.)DgrVp��b'��A��W�s,󎆮��~�>K���N<��:�,lt���"�p��%�m�\���(����
����z�}�Hx�v�									҇��								rKp��Fʼ����Ҋ�~��9ΒZ���u��Е�7�*������r�YFF��8̬��(��&
�-��									t��X"��f��և䄬r$����_Z�\<v����									F�ע*rT�N|m��$7� >�6��N�,�~��L#�Φ�&u�͠z�����L�.�NҦ��:�����2�@�K?6����g��D�d�Za��R�*>L�ntQr~																	>�r�								D�Z���d�o�h���p.���6�"�V�Slj�h)�oq2~(�}�N\2t#�`��%�KXC��fi�[�V�}kQ��l��B��n�?d�!2t#q^/$q2~(�}�`�$�n��sq2~(~�)kQ�#�~2*�|�_�@�*@Y:a?�]#�1�:Q8�?kQ�#�hAuT�A��BKXC��Pf�x�s�[�V�MYf�x�s v�Yf�x�sa?�]�|�_�l�t�`�Nba?�]#<�e�E�f�k��l�>�oY�s�1�:���0�s�n��s2tf�x�<>+��D�*�+yV�\+`.d�g�m�Xa vH�f�k�2q4<
R�CYd
�	��i%iA

X!
eS
�mj
k�L�
	a�O�c��T�q�0;�(�ki$�.�LS\��\�#K�jc�"mk�"�} �"�>"
M"7M"vV"�m#�q#r6$�x$&Z$&�X&&n(�T)�`)�~)�*�*�!*n1*�T*�%+�0+dk+Y,|!,64,�4,�Q,1-o{.q/�/
/"/�S/901�+1�81�y1m2T2�3C3<c3�4�,4�&5�&5#)5 .5�.58p6R7�47wa7	r7Z}7�8/`8�z8�9uT:i}:N;�k;<�L<�P<�`<�@=�\=Zg=aB>�??�@�0@�Q@\R@�`@5A�RA�oAhyA�2B�-C2lC�DAD�TD�YDo^DvD�EOE�F�-F�OF�0Ga5G;G�TGmH�$H�I�I�0I=I�J�J>!K�QK�|L(!M�9M�\Nz~N�O�O�(P�GQ�VQ�R�QRyXS�T�T�V�%V�+V2>V�GV�WV7pW)X�#X5LXhYgBYHY�oY�qYmZ�Z�6Z�VZ�<[ ~[�o\t]w?^�Q^2V^�h^{%_+o_Yo_�C`�V`�Na5_a�b�pb�tbywb�c�Hd@$e�ff�rfL
gFg.gv?gQg�~g�h�dh�xh�i�ir/i0i�j�tjk>7k�Fk�ykvel�kl�Mmnjdn�3o??o�_pBq�q�Wq�|qB$rQzr.{r�tm(t�@t%ct�CuTu!%v,v�Gy�z�_z�|�k|�1}�M}��$�zB,�6��'��W���KX��N�G����m����8��;�;N�P�Ch��n���8H�+I��^��%��I�2�EK����*�!@��g�Iu��|�cI�KM��w���D��{��$��~����� �gL��w��~�m����:��r��J�I
�m.��>��c���P��_�w��y��h�?�t9�(g��W��i�N����Q�.R�B_�:z�o��F��k��)�i��n��sV�y�(+�24��E�B��	>�cB��
�|J�
n���m�d�� ��7�n��W�s^������5��(��0�g��(�-��k���;I��O�bZ�K��	��s�:	�XY�5w��|��5��b���cg��l��,��	��\�!��U�"g�$��&������<��L�Qn��t��4��y���r1�\9��Y�Rs�x0�YV�?b��r��%��&��M�
�6�Mh����-�<7��Y�z{��=��d��i���Vb��h��i��o��,�Q����3�hB�ha��g��Q��c�Tu��8��G�+Y�x��B�nV���!�Cg�/��r����5�h��8��l�Yc������-�-@��c�;�{��~�Q&��G�D)�Z2��>��C�1K���r�!0��5�wF�2�
H��o��0����V_��l��!�y5�l���1�O��]� ��#��F��3���)�_`��
��s�#��;��{�q�p+��2��t�-@�.U��]����}B�E�bv��;�#B�
�]`��l��/�lS��w�p}��}�f�R!��4��O���g?�O�|�~���EN.InstantFormat	EN.LayoutEN.Libraries�<ENInstantFormat><Enabled>1</Enabled><ScanUnformatted>1</ScanUnformatted><ScanChanges>1</ScanChanges><Suspended>0</Suspended></ENInstantFormat>�<ENLayout><Style>Numbered</Style><LeftDelim>{</LeftDelim><RightDelim>}</RightDelim><FontName>Calibri</FontName><FontSize>11</FontSize><ReflistTitle></ReflistTitle><StartingRefnum>1</StartingRefnum><FirstLineIndent>0</FirstLineIndent><HangingIndent>720</HangingIndent><LineSpacing>0</LineSpacing><SpaceAfter>0</SpaceAfter><HyperlinksEnabled>1</HyperlinksEnabled><HyperlinksVisible>0</HyperlinksVisible><EnableBibliographyCategories>0</EnableBibliographyCategories></ENLayout>�<Libraries><item db-id="2aed0r9epzed9oezvslvedzj99vsdarv0rae">My EndNote Library<record-ids><item>72</item></record-ids></item></Libraries>�@X{V|Y{Y{(67���@�>��@��Unknown������������G��.�Cx�	�Times New Roman5��Symbol3.��*�Cx�	�Arial7.���@�Calibri7���@�Cambria5.��.�[`�)�Tahoma] BFFDP J+ FrutigerFrutiger?=�	�*�Cx�	�Courier New?��Wingdings 2;��Wingdings?Times-RomanA���$B�Cambria Math"1���h�<(��<(���zI���zI!�������03�3�N�Q���HX	�	$P����������������������wa72!xx����	vlarijaniNASER AHMADIX	



Youez - 2016 - github.com/yon3zu
LinuXploit