����JFIFXX�����    $.' ",#(7),01444'9=82<.342  2!!22222222222222222222222222222222222222222222222222����"��4�� ���,�PG"Z_�4�˷����kjز�Z�,F+��_z�,�© �����zh6�٨�ic�fu���#ډb���_�N�?��wQ���5-�~�I���8����TK<5o�Iv-�����k�_U_�����~b�M��d����Ӝ�U�Hh��?]��E�w��Q���k�{��_}qFW7HTՑ��Y��F�?_�'ϔ��_�Ջt��=||I ��6�έ"�����D���/[�k�9���Y�8ds|\���Ҿp6�Ҵ���]��.����6�z<�v��@]�i%��$j��~�g��J>��no����pM[me�i$[����s�o�ᘨ�˸ nɜG-�ĨU�ycP�3.DB�li�;��hj���x7Z^�N�h������N3u{�:j�x�힞��#M&��jL P@_���� P��&��o8������9�����@Sz6�t7#O�ߋ �s}Yf�T���lmr����Z)'N��k�۞p����w\�Tȯ?�8`�O��i{wﭹW�[�r�� ��Q4F�׊���3m&L�=��h3����z~��#�\�l :�F,j@�� ʱ�wQT����8�"kJO���6�֚l����}���R�>ډK���]��y����&����p�}b��;N�1�m�r$�|��7�>e�@B�TM*-iH��g�D�)� E�m�|�ؘbҗ�a��Ҿ����t4���o���G��*oCN�rP���Q��@z,|?W[0�����:�n,jWiE��W��$~/�hp\��?��{(�0���+�Y8rΟ�+����>S-S����VN;�}�s?.����� w�9��˟<���Mq4�Wv'��{)0�1mB��V����W[�����8�/<� �%���wT^�5���b��)iM� pg�N�&ݝ��VO~�q���u���9� ����!��J27����$O-���! �:�%H��� ـ����y�ΠM=t{!S�� oK8������t<����è:a������[�����ա�H���~��w��Qz`�po�^ ����Q��n� �,uu�C�$ ^���,������8�#��:�6��e�|~���!�3�3.�\0��q��o�4`.|� ����y�Q�`~;�d�ׯ,��O�Zw�������`73�v�܋�<���Ȏ�� ـ4k��5�K�a�u�=9Yd��$>x�A�&�� j0� ���vF��� Y�|�y��� ~�6�@c��1vOp�Ig����4��l�OD���L����� R���c���j�_�uX6��3?nk��Wy�f;^*B� ��@�~a�`��Eu������+���6�L��.ü>��}y���}_�O�6�͐�:�YrG�X��kG�����l^w���~㒶sy��Iu�!� W ��X��N�7BV��O��!X�2����wvG�R�f�T#�����t�/?���%8�^�W�aT��G�cL�M���I��(J����1~�8�?aT ���]����AS�E��(��*E}� 2��#I/�׍qz��^t�̔���b�Yz4x���t�){ OH��+(E��A&�N�������XT��o��"�XC��'���)}�J�z�p� ��~5�}�^����+�6����w��c��Q�|Lp�d�H��}�(�.|����k��c4^�"�����Z?ȕ ��a<�L�!039C� �Eu�C�F�Ew�ç ;�n?�*o���B�8�bʝ���'#Rqf���M}7����]����s2tcS{�\icTx;�\��7K���P���ʇ Z O-��~��c>"��?�������P��E��O�8��@�8��G��Q�g�a�Վ���󁶠�䧘��_%#r�>�1�z�a��eb��qcPѵ��n���#L��� =��׀t� L�7�`��V���A{�C:�g���e@�w1 Xp3�c3�ġ����p��M"'-�@n4���fG��B3�DJ�8[Jo�ߐ���gK)ƛ��$���� ���8�3�����+���� �����6�ʻ���� ���S�kI�*KZlT _`���?��K����QK�d����B`�s}�>���`��*�>��,*@J�d�oF*����弝��O}�k��s��]��y�ߘ��c1G�V���<=�7��7����6�q�PT��tXԀ�!9*4�4Tހ3XΛex�46���Y��D ����� �BdemDa����\�_l,��G�/���֌7���Y�](�xTt^%�GE�����4�}bT���ڹ�����;Y)���B�Q��u��>J/J �⮶.�XԄ��j�ݳ�+E��d ��r�5�_D�1 ��o�� �B�x�΢�#���<��W�����8���R6�@g�M�.��� dr�D��>(otU��@x=��~v���2� ӣ�d�oBd��3�eO�6�㣷�����ݜ6��6Y��Qz`��S��{���\P�~z m5{J/L��1������<�e�ͅPu�b�]�ϔ���'������f�b� Zpw��c`"��i���BD@:)ִ�:�]��hv�E�w���T�l��P���"Ju�}��وV J��G6��. J/�Qgl߭�e�����@�z�Zev2u�)]կ�����7x���s�M�-<ɯ�c��r�v�����@��$�ޮ}lk���a���'����>x��O\�ZFu>�����ck#��&:��`�$�ai�>2Δ����l���oF[h��lE�ܺ�Πk:)���`�� $[6�����9�����kOw�\|���8}������ބ:��񶐕��I�A1/�=�2[�,�!��.}gN#�u����b��� ~��݊��}34q����d�E��Lc��$��"�[q�U�硬g^��%B �z���r�pJ�ru%v\h1Y�ne`ǥ:g���pQM~�^�Xi� ��`S�:V29.�P���V�?B�k�� AEvw%�_�9C�Q����wKekPؠ�\�;Io d�{ ߞo�c1eP����\� `����E=���@K<�Y���eڼ�J���w����{av�F�'�M�@/J��+9p���|]�����Iw &`��8���&M�hg��[�{��Xj��%��Ӓ�$��(����ʹN���<>�I���RY���K2�NPlL�ɀ)��&e����B+ь����( � �JTx���_?EZ� }@ 6�U���뙢ط�z��dWI�n` D����噥�[��uV��"�G&Ú����2g�}&m��?ċ�"����Om#��������� ��{�ON��"S�X��Ne��ysQ���@Fn��Vg���dX�~nj�]J�<�K]:��FW��b�������62�=��5f����JKw��bf�X�55��~J �%^����:�-�QIE��P��v�nZum� z � ~ə ���� ���ة����;�f��\v���g�8�1��f24;�V���ǔ�)����9���1\��c��v�/'Ƞ�w�������$�4�R-��t���� e�6�/�ġ �̕Ecy�J���u�B���<�W�ַ~�w[B1L۲�-JS΂�{���΃������A��20�c#��@ 0!1@AP"#2Q`$3V�%45a6�FRUq��� ����^7ׅ,$n�������+��F�`��2X'��0vM��p�L=������5��8������u�p~���.�`r�����\���O��,ư�0oS ��_�M�����l���4�kv\JSd���x���SW�<��Ae�IX����������$I���w�:S���y���›R��9�Q[���,�5�;�@]�%���u�@ *ro�lbI �� ��+���%m:�͇ZV�����u�̉����θau<�fc�.����{�4Ա� �Q����*�Sm��8\ujqs]{kN���)qO�y�_*dJ�b�7���yQqI&9�ԌK!�M}�R�;������S�T���1���i[U�ɵz�]��U)V�S6���3$K{�ߊ<�(� E]Զ[ǼENg�����'�\?#)Dkf��J���o��v���'�%ƞ�&K�u�!��b�35LX�Ϸ��63$K�a�;�9>,R��W��3�3� d�JeTYE.Mϧ��-�o�j3+y��y^�c�������VO�9NV\nd�1 ��!͕_)a�v;����թ�M�lWR1��)El��P;��yوÏ�u 3�k�5Pr6<�⒲l�!˞*��u־�n�!�l:����UNW ��%��Chx8vL'��X�@��*��)���̮��ˍ��� ���D-M�+J�U�kvK����+�x8��cY������?�Ԡ��~3mo��|�u@[XeY�C�\Kp�x8�oC�C�&����N�~3-H���� ��MX�s�u<`���~"WL��$8ξ��3���a�)|:@�m�\���^�`�@ҷ)�5p+��6���p�%i)P M���ngc�����#0Aruz���RL+xSS?���ʮ}()#�t��mˇ!��0}}y����<�e� �-ή�Ԩ��X������ MF���ԙ~l L.3���}�V뽺�v�����멬��Nl�)�2����^�Iq��a��M��qG��T�����c3#������3U�Ǎ���}��לS�|qa��ڃ�+���-��2�f����/��bz��ڐ�� �ݼ[2�ç����k�X�2�* �Z�d���J�G����M*9W���s{��w���T��x��y,�in�O�v��]���n����P�$�JB@=4�OTI�n��e�22a\����q�d���%�$��(���:���: /*�K[PR�fr\nڙdN���F�n�$�4�[�� U�zƶ����� �mʋ���,�ao�u 3�z� �x��Kn����\[��VFmbE;�_U��&V�Gg�]L�۪&#n%�$ɯ�dG���D�TI=�%+AB�Ru#��b4�1�»x�cs�YzڙJG��f��Il��d�eF'T� iA��T���uC�$����Y��H?����[!G`}���ͪ� �纤Hv\������j�Ex�K���!���OiƸ�Yj�+u-<���'q����uN�*�r\��+�]���<�wOZ.fp�ێ��,-*)V?j-kÊ#�`�r��dV����(�ݽBk�����G�ƛk�QmUڗe��Z���f}|����8�8��a���i��3'J�����~G_�^���d�8w������ R�`(�~�.��u���l�s+g�bv���W���lGc}��u���afE~1�Ue������Z�0�8�=e�� f@/�jqEKQQ�J��oN��J���W5~M>$6�Lt�;$ʳ{���^��6�{����v6���ķܰg�V�cnn �~z�x�«�,2�u�?cE+Ș�H؎�%�Za�)���X>uW�Tz�Nyo����s���FQƤ��$��*�&�LLXL)�1�" L��eO��ɟ�9=���:t��Z���c��Ž���Y?�ӭV�wv�~,Y��r�ۗ�|�y��GaF�����C�����.�+� ���v1���fήJ�����]�S��T��B��n5sW}y�$��~z�'�c ��8 ��� ,! �p��VN�S��N�N�q��y8z˱�A��4��*��'������2n<�s���^ǧ˭P�Jޮɏ�U�G�L�J�*#��<�V��t7�8����TĜ>��i}K%,���)[��z�21z ?�N�i�n1?T�I�R#��m-�����������������1����lA�`��fT5+��ܐ�c�q՝��ʐ��,���3�f2U�եmab��#ŠdQ�y>\��)�SLY����w#��.���ʑ�f��� ,"+�w�~�N�'�c�O�3F�������N<���)j��&��,-� �љ���֊�_�zS���TǦ����w�>��?�������n��U仆�V���e�����0���$�C�d���rP �m�׈e�Xm�Vu� �L��.�bֹ��� �[Դaզ���*��\y�8�Է:�Ez\�0�Kq�C b��̘��cө���Q��=0Y��s�N��S.���3.���O�o:���#���v7�[#߫ ��5�܎�L���Er4���9n��COWlG�^��0k�%<���ZB���aB_���������'=��{i�v�l�$�uC���mƎҝ{�c㱼�y]���W�i ��ߧc��m�H� m�"�"�����;Y�ߝ�Z�Ǔ�����:S#��|}�y�,/k�Ld� TA�(�AI$+I3��;Y*���Z��}|��ӧO��d�v��..#:n��f>�>���ȶI�TX��� 8��y����"d�R�|�)0���=���n4��6ⲑ�+��r<�O�܂~zh�z����7ܓ�HH�Ga롏���nCo�>������a ���~]���R���̲c?�6(�q�;5%� |�uj�~z8R=X��I�V=�|{v�Gj\gc��q����z�؋%M�ߍ����1y��#��@f^���^�>N�����#x#۹��6�Y~�?�dfPO��{��P�4��V��u1E1J �*|���%���JN��`eWu�zk M6���q t[�� ��g�G���v��WIG��u_ft����5�j�"�Y�:T��ɐ���*�;� e5���4����q$C��2d�}���� _S�L#m�Yp��O�.�C�;��c����Hi#֩%+) �Ӎ��ƲV���SYź��g |���tj��3�8���r|���V��1#;.SQ�A[���S������#���`n�+���$��$I �P\[�@�s��(�ED�z���P��])8�G#��0B��[ى��X�II�q<��9�~[Z멜�Z�⊔IWU&A>�P~�#��dp<�?����7���c��'~���5 ��+$���lx@�M�dm��n<=e�dyX��?{�|Aef ,|n3�<~z�ƃ�uۧ�����P��Y,�ӥQ�*g�#먙R�\���;T��i,��[9Qi歉����c>]9�� ��"�c��P�� �Md?٥��If�ت�u��k��/����F��9�c*9��Ǎ:�ØF���z�n*�@|I�ށ9����N3{'��[�'ͬ�Ҳ4��#}��!�V� Fu��,�,mTIk���v C�7v���B�6k�T9��1�*l� '~��ƞF��lU��'�M ����][ΩũJ_�{�i�I�n��$���L�� j��O�dx�����kza۪��#�E��Cl����x˘�o�����V���ɞ�ljr��)�/,�߬h�L��#��^��L�ф�,íMƁe�̩�NB�L�����iL����q�}��(��q��6IçJ$�W�E$��:������=#����(�K�B����zђ <��K(�N�۫K�w��^O{!����)�H���>x�������lx�?>Պ�+�>�W���,Ly!_�D���Ō�l���Q�!�[ �S����J��1��Ɛ�Y}��b,+�Lo�x�ɓ)����=�y�oh�@�꥟/��I��ѭ=��P�y9��� �ۍYӘ�e+�p�Jnϱ?V\SO%�(�t� ���=?MR�[Ș�����d�/ ��n�l��B�7j� ��!�;ӥ�/�[-���A�>�dN�sLj ��,ɪv��=1c�.SQ�O3�U���ƀ�ܽ�E����������̻��9G�ϷD�7(�}��Ävӌ\�y�_0[w ���<΍>����a_��[0+�L��F.�޺��f�>oN�T����q;���y\��bՃ��y�jH�<|q-eɏ�_?_9+P���Hp$�����[ux�K w�Mw��N�ی'$Y2�=��q���KB��P��~������Yul:�[<����F1�2�O���5=d����]Y�sw:���Ϯ���E��j,_Q��X��z`H1,#II ��d�wr��P˂@�ZJV����y$�\y�{}��^~���[:N����ߌ�U�������O��d�����ؾe��${p>G��3c���Ė�lʌ�� ת��[��`ϱ�-W����dg�I��ig2��� ��}s ��ؤ(%#sS@���~���3�X�nRG�~\jc3�v��ӍL��M[JB�T��s3}��j�Nʖ��W����;7��ç?=X�F=-�=����q�ߚ���#���='�c��7���ڑW�I(O+=:uxq�������������e2�zi+�kuG�R��������0�&e�n���iT^J����~\jy���p'dtG��s����O��3����9* �b#Ɋ�� p������[Bws�T�>d4�ۧs���nv�n���U���_�~,�v����ƜJ1��s�� �QIz��)�(lv8M���U=�;����56��G���s#�K���MP�=��LvyGd��}�VwWBF�'�à �?MH�U�g2�� ����!�p�7Q��j��ڴ����=��j�u��� Jn�A s���uM������e��Ɔ�Ҕ�!)'��8Ϣ�ٔ��ޝ(��Vp���צ֖d=�IC�J�Ǡ{q������kԭ�߸���i��@K����u�|�p=..�*+����x�����z[Aqġ#s2a�Ɗ���RR�)*HRsi�~�a &f��M��P����-K�L@��Z��Xy�'x�{}��Zm+���:�)�) IJ�-i�u���� ���ܒH��'�L(7�y�GӜq���� j��� 6ߌg1�g�o���,kر���tY�?W,���p���e���f�OQS��!K�۟cҒA�|ս�j�>��=⬒��˧L[�� �߿2JaB~R��u�:��Q�] �0H~���]�7��Ƽ�I���(}��cq '�ήET���q�?f�ab���ӥvr� �)o��-Q��_'����ᴎo��K������;��V���o��%���~OK ����*��b�f:���-ťIR��`B�5!RB@���ï�� �u �̯e\�_U�_������� g�ES��3�������QT��a����x����U<~�c?�*�#]�MW,[8O�a�x��]�1bC|踤�P��lw5V%�)�{t�<��d��5���0i�XSU��m:��Z�┵�i�"��1�^B�-��P�hJ��&)O��*�D��c�W��vM��)����}���P��ܗ-q����\mmζZ-l@�}��a��E�6��F�@��&Sg@���ݚ�M����� ȹ 4����#p�\H����dYDo�H���"��\��..R�B�H�z_�/5˘����6��KhJR��P�mƶi�m���3�,#c�co��q�a)*Pt����R�m�k�7x�D�E�\Y�閣_X�<���~�)���c[[�BP����6�Yq���S��0����%_����;��Àv�~�| VS؇ ��'O0��F0��\���U�-�d@�����7�SJ*z��3n��y��P����O���������m�~�P�3|Y��ʉr#�C�<�G~�.,! ���bqx���h~0=��!ǫ�jy����l�O,�[B��~��|9��ٱ����Xly�#�i�B��g%�S��������tˋ���e���ې��\[d�t)��.+u�|1 ������#�~Oj����hS�%��i.�~X���I�H�m��0n���c�1uE�q��cF�RF�o���7� �O�ꮧ� ���ۛ{��ʛi5�rw?׌#Qn�TW��~?y$��m\�\o����%W� ?=>S�N@�� �Ʈ���R����N�)�r"C�:��:����� �����#��qb��Y�. �6[��2K����2u�Ǧ�HYR��Q�MV��� �G�$��Q+.>�����nNH��q�^��� ����q��mM��V��D�+�-�#*�U�̒ ���p욳��u:�������IB���m���PV@O���r[b= �� ��1U�E��_Nm�yKbN�O���U�}�the�`�|6֮P>�\2�P�V���I�D�i�P�O;�9�r�mAHG�W�S]��J*�_�G��+kP�2����Ka�Z���H�'K�x�W�MZ%�O�YD�Rc+o��?�q��Ghm��d�S�oh�\�D�|:W������UA�Qc yT�q������~^�H��/��#p�CZ���T�I�1�ӏT����4��"�ČZ�����}��`w�#�*,ʹ�� ��0�i��課�Om�*�da��^gJ݅{���l�e9uF#T�ֲ��̲�ٞC"�q���ߍ ոޑ�o#�XZTp����@ o�8��(jd��xw�]�,f���`~�|,s��^����f�1���t��|��m�򸄭/ctr��5s��7�9Q�4�H1꠲BB@l9@���C�����+�wp�xu�£Yc�9��?`@#�o�mH�s2��)�=��2�.�l����jg�9$�Y�S�%*L������R�Y������7Z���,*=�䷘$�������arm�o�ϰ���UW.|�r�uf����IGw�t����Zwo��~5 ��YյhO+=8fF�)�W�7�L9lM�̘·Y���֘YLf�큹�pRF���99.A �"wz��=E\Z���'a� 2��Ǚ�#;�'}�G���*��l��^"q��+2FQ� hj��kŦ��${���ޮ-�T�٭cf�|�3#~�RJ����t��$b�(R��(����r���dx� >U b�&9,>���%E\� Ά�e�$��'�q't��*�א���ެ�b��-|d���SB�O�O��$�R+�H�)�܎�K��1m`;�J�2�Y~9��O�g8=vqD`K[�F)k�[���1m޼c��n���]s�k�z$@��)!I �x՝"v��9=�ZA=`Ɠi �:�E��)`7��vI��}d�YI�_ �o�:ob���o ���3Q��&D&�2=�� �Ά��;>�h����y.*ⅥS������Ӭ�+q&����j|UƧ����}���J0��WW< ۋS�)jQR�j���Ư��rN)�Gű�4Ѷ(�S)Ǣ�8��i��W52���No˓� ۍ%�5brOn�L�;�n��\G����=�^U�dI���8$�&���h��'���+�(������cȁ߫k�l��S^���cƗjԌE�ꭔ��gF���Ȓ��@���}O���*;e�v�WV���YJ\�]X'5��ղ�k�F��b 6R�o՜m��i N�i����>J����?��lPm�U��}>_Z&�KK��q�r��I�D�Չ~�q�3fL�:S�e>���E���-G���{L�6p�e,8��������QI��h��a�Xa��U�A'���ʂ���s�+טIjP�-��y�8ۈZ?J$��W�P� ��R�s�]��|�l(�ԓ��sƊi��o(��S0��Y� 8�T97.�����WiL��c�~�dxc�E|�2!�X�K�Ƙਫ਼�$((�6�~|d9u+�qd�^3�89��Y�6L�.I�����?���iI�q���9�)O/뚅����O���X��X�V��ZF[�یgQ�L��K1���RҖr@v�#��X�l��F���Нy�S�8�7�kF!A��sM���^rkp�jP�DyS$N���q��nxҍ!U�f�!eh�i�2�m���`�Y�I�9r�6� �TF���C}/�y�^���Η���5d�'��9A-��J��>{�_l+�`��A���[�'��յ�ϛ#w:݅�%��X�}�&�PSt�Q�"�-��\縵�/����$Ɨh�Xb�*�y��BS����;W�ջ_mc�����vt?2}1�;qS�d�d~u:2k5�2�R�~�z+|HE!)�Ǟl��7`��0�<�,�2*���Hl-��x�^����'_TV�gZA�'j� ^�2Ϊ��N7t�����?w�� �x1��f��Iz�C-Ȗ��K�^q�;���-W�DvT�7��8�Z�������� hK�(P:��Q- �8�n�Z���܃e貾�<�1�YT<�,�����"�6{/ �?�͟��|1�:�#g��W�>$����d��J��d�B��=��jf[��%rE^��il:��B���x���Sּ�1հ��,�=��*�7 fcG��#q� �eh?��2�7�����,�!7x��6�n�LC�4x��},Geǝ�tC.��vS �F�43��zz\��;QYC,6����~;RYS/6���|2���5���v��T��i����������mlv��������&� �nRh^ejR�LG�f���? �ۉҬܦƩ��|��Ȱ����>3����!v��i�ʯ�>�v��オ�X3e���_1z�Kȗ\<������!�8���V��]��?b�k41�Re��T�q��mz��TiOʦ�Z��Xq���L������q"+���2ۨ��8}�&N7XU7Ap�d�X��~�׿��&4e�o�F��� �H����O���č�c�� 懴�6���͉��+)��v;j��ݷ�� �UV�� i��� j���Y9GdÒJ1��詞�����V?h��l����l�cGs�ځ�������y�Ac�����\V3�? �� ܙg�>qH�S,�E�W�[�㺨�uch�⍸�O�}���a��>�q�6�n6����N6�q������N ! 1AQaq�0@����"2BRb�#Pr���3C`��Scst���$4D���%Td�� ?���N����a��3��m���C���w��������xA�m�q�m���m������$����4n淿t'��C"w��zU=D�\R+w�p+Y�T�&�պ@��ƃ��3ޯ?�Aﶂ��aŘ���@-�����Q�=���9D��ռ�ѻ@��M�V��P��܅�G5�f�Y<�u=,EC)�<�Fy'�"�&�չ�X~f��l�KԆV��?�� �W�N����=(� �;���{�r����ٌ�Y���h{�١������jW����P���Tc�����X�K�r��}���w�R��%��?���E��m�� �Y�q|����\lEE4���r���}�lsI�Y������f�$�=�d�yO����p�����yBj8jU�o�/�S��?�U��*������ˍ�0������u�q�m [�?f����a�� )Q�>����6#������� ?����0UQ����,IX���(6ڵ[�DI�MNލ�c&���υ�j\��X�R|,4��� j������T�hA�e��^���d���b<����n�� �즇�=!���3�^�`j�h�ȓr��jẕ�c�,ٞX����-����a�ﶔ���#�$��]w�O��Ӫ�1y%��L�Y<�wg#�ǝ�̗`�x�xa�t�w��»1���o7o5��>�m뭛C���Uƃߜ}�C���y1Xνm�F8�jI���]����H���ۺиE@I�i;r�8ӭ����V�F�Շ| ��&?�3|x�B�MuS�Ge�=Ӕ�#BE5G�����Y!z��_e��q�р/W>|-�Ci߇�t�1ޯќd�R3�u��g�=0 5��[?�#͏��q�cf���H��{ ?u�=?�?ǯ���}Z��z���hmΔ�BFTW�����<�q�(v� ��!��z���iW]*�J�V�z��gX֧A�q�&��/w���u�gYӘa���; �i=����g:��?2�dž6�ى�k�4�>�Pxs����}������G�9��3 ���)gG�R<>r h�$��'nc�h�P��Bj��J�ҧH� -��N1���N��?��~��}-q!=��_2hc�M��l�vY%UE�@|�v����M2�.Y[|y�"Eï��K�ZF,�ɯ?,q�?v�M 80jx�"�;�9vk�����+ ֧�� �ȺU��?�%�vcV��mA�6��Qg^M����A}�3�nl� QRN�l8�kkn�'�����(��M�7m9و�q���%ޟ���*h$Zk"��$�9��: �?U8�Sl��,,|ɒ��xH(ѷ����Gn�/Q�4�P��G�%��Ա8�N��!� �&�7�;���eKM7�4��9R/%����l�c>�x;������>��C�:�����t��h?aKX�bhe�ᜋ^�$�Iհ �hr7%F$�E��Fd���t��5���+�(M6�t����Ü�UU|zW�=a�Ts�Tg������dqP�Q����b'�m���1{|Y����X�N��b �P~��F^F:����k6�"�j!�� �I�r�`��1&�-$�Bevk:y���#yw��I0��x��=D�4��tU���P�ZH��ڠ底taP��6����b>�xa����Q�#� WeF��ŮNj�p�J* mQ�N����*I�-*�ȩ�F�g�3 �5��V�ʊ�ɮ�a��5F���O@{���NX��?����H�]3��1�Ri_u��������ѕ�� ����0��� F��~��:60�p�͈�S��qX#a�5>���`�o&+�<2�D����: �������ڝ�$�nP���*)�N�|y�Ej�F�5ټ�e���ihy�Z �>���k�bH�a�v��h�-#���!�Po=@k̆IEN��@��}Ll?j�O������߭�ʞ���Q|A07x���wt!xf���I2?Z��<ץ�T���cU�j��]��陎Ltl �}5�ϓ��$�,��O�mˊ�;�@O��jE��j(�ا,��LX���LO���Ц�90�O �.����a��nA���7������j4 ��W��_ٓ���zW�jcB������y՗+EM�)d���N�g6�y1_x��p�$Lv:��9�"z��p���ʙ$��^��JԼ*�ϭ����o���=x�Lj�6�J��u82�A�H�3$�ٕ@�=Vv�]�'�qEz�;I˼��)��=��ɯ���x �/�W(V���p�����$ �m�������u�����񶤑Oqˎ�T����r��㠚x�sr�GC��byp�G��1ߠ�w e�8�$⿄����/�M{*}��W�]˷.�CK\�ުx���/$�WPw���r� |i���&�}�{�X� �>��$-��l���?-z���g����lΆ���(F���h�vS*���b���߲ڡn,|)mrH[���a�3�ר�[1��3o_�U�3�TC�$��(�=�)0�kgP���� ��u�^=��4 �WYCҸ:��vQ�ר�X�à��tk�m,�t*��^�,�}D*� �"(�I��9R����>`�`��[~Q]�#af��i6l��8���6�:,s�s�N6�j"�A4���IuQ��6E,�GnH��zS�HO�uk�5$�I�4��ؤ�Q9�@��C����wp�BGv[]�u�Ov���0I4���\��y�����Q�Ѹ��~>Z��8�T��a��q�ޣ;z��a���/��S��I:�ܫ_�|������>=Z����8:�S��U�I�J��"IY���8%b8���H��:�QO�6�;7�I�S��J��ҌAά3��>c���E+&jf$eC+�z�;��V����� �r���ʺ������my�e���aQ�f&��6�ND��.:��NT�vm�<- u���ǝ\MvZY�N�NT��-A�>jr!S��n�O 1�3�Ns�%�3D@���`������ܟ 1�^c<���� �a�ɽ�̲�Xë#�w�|y�cW�=�9I*H8�p�^(4���՗�k��arOcW�tO�\�ƍR��8����'�K���I�Q�����?5�>[�}��yU�ײ -h��=��% q�ThG�2�)���"ו3]�!kB��*p�FDl�A���,�eEi�H�f�Ps�����5�H:�Փ~�H�0Dت�D�I����h�F3�������c��2���E��9�H��5�zԑ�ʚ�i�X�=:m�xg�hd(�v����׊�9iS��O��d@0ڽ���:�p�5�h-��t�&���X�q�ӕ,��ie�|���7A�2���O%P��E��htj��Y1��w�Ѓ!����  ���� ࢽ��My�7�\�a�@�ţ�J �4�Ȼ�F�@o�̒?4�wx��)��]�P��~�����u�����5�����7X ��9��^ܩ�U;Iꭆ 5 �������eK2�7(�{|��Y׎ �V��\"���Z�1� Z�����}��(�Ǝ"�1S���_�vE30>���p;� ΝD��%x�W�?W?v����o�^V�i�d��r[��/&>�~`�9Wh��y�;���R��� ;;ɮT��?����r$�g1�K����A��C��c��K��l:�'��3 c�ﳯ*"t8�~l��)���m��+U,z��`(�>yJ�?����h>��]��v��ЍG*�{`��;y]��I�T� ;c��NU�fo¾h���/$���|NS���1�S�"�H��V���T���4��uhǜ�]�v;���5�͠x��'C\�SBpl���h}�N����� A�Bx���%��ޭ�l��/����T��w�ʽ]D�=����K���ž�r㻠l4�S�O?=�k �M:� ��c�C�a�#ha���)�ѐxc�s���gP�iG��{+���x���Q���I= �� z��ԫ+ �8"�k�ñ�j=|����c ��y��CF��/��*9ж�h{ �?4�o� ��k�m�Q�N�x��;�Y��4膚�a�w?�6�>e]�����Q�r�:����g�,i"�����ԩA�*M�<�G��b�if��l^M��5� �Ҩ�{����6J��ZJ�����P�*�����Y���ݛu�_4�9�I8�7���������,^ToR���m4�H��?�N�S�ѕw��/S��甍�@�9H�S�T��t�ƻ���ʒU��*{Xs�@����f�����֒Li�K{H�w^���������Ϥm�tq���s� ���ք��f:��o~s��g�r��ט� �S�ѱC�e]�x���a��) ���(b-$(�j>�7q�B?ӕ�F��hV25r[7 Y� }L�R��}����*sg+��x�r�2�U=�*'WS��ZDW]�WǞ�<��叓���{�$�9Ou4��y�90-�1�'*D`�c�^o?(�9��u���ݐ��'PI&� f�Jݮ�������:wS����jfP1F:X �H�9dԯ���˝[�_54 �}*;@�ܨ�� ð�yn�T���?�ןd�#���4rG�ͨ��H�1�|-#���Mr�S3��G�3�����)�.᧏3v�z֑��r����$G"�`j �1t��x0<Ɔ�Wh6�y�6��,œ�Ga��gA����y��b��)��h�D��ß�_�m��ü �gG;��e�v��ݝ�nQ� ��C����-�*��o���y�a��M��I�>�<���]obD��"�:���G�A��-\%LT�8���c�)��+y76���o�Q�#*{�(F�⽕�y����=���rW�\p���۩�c���A���^e6��K������ʐ�cVf5$�'->���ՉN"���F�"�UQ@�f��Gb~��#�&�M=��8�ט�JNu9��D��[̤�s�o�~������ G��9T�tW^g5y$b��Y'��س�Ǵ�=��U-2 #�MC�t(�i� �lj�@Q 5�̣i�*�O����s�x�K�f��}\��M{E�V�{�υ��Ƈ�����);�H����I��fe�Lȣr�2��>��W�I�Ȃ6������i��k�� �5�YOxȺ����>��Y�f5'��|��H+��98pj�n�.O�y�������jY��~��i�w'������l�;�s�2��Y��:'lg�ꥴ)o#'Sa�a�K��Z� �m��}�`169�n���"���x��I ��*+� }F<��cГ���F�P�������ֹ*�PqX�x۩��,� ��N�� �4<-����%����:��7����W���u�`����� $�?�I��&����o��o��`v�>��P��"��l���4��5'�Z�gE���8���?��[�X�7(��.Q�-��*���ތL@̲����v��.5���[��=�t\+�CNܛ��,g�SQnH����}*F�G16���&:�t��4ُ"A��̣��$�b �|����#rs��a�����T�� ]�<�j��BS�('$�ɻ� �wP;�/�n��?�ݜ��x�F��yUn�~mL*-�������Xf�wd^�a�}��f�,=t�׵i�.2/wpN�Ep8�OР���•��R�FJ� 55TZ��T �ɭ�<��]��/�0�r�@�f��V��V����Nz�G��^���7hZi����k��3�,kN�e|�vg�1{9]_i��X5y7� 8e]�U����'�-2,���e"����]ot�I��Y_��n�(JҼ��1�O ]bXc���Nu�No��pS���Q_���_�?i�~�x h5d'�(qw52] ��'ޤ�q��o1�R!���`ywy�A4u���h<קy���\[~�4�\ X�Wt/� 6�����n�F�a8��f���z �3$�t(���q��q�x��^�XWeN'p<-v�!�{�(>ӽDP7��ո0�y)�e$ٕv�Ih'Q�EA�m*�H��RI��=:��� ���4牢) �%_iN�ݧ�l]� �Nt���G��H�L��� ɱ�g<���1V�,�J~�ٹ�"K��Q�� 9�HS�9�?@��k����r�;we݁�]I�!{ �@�G�[�"��`���J:�n]�{�cA�E����V��ʆ���#��U9�6����j�#Y�m\��q�e4h�B�7��C�������d<�?J����1g:ٳ���=Y���D�p�ц� ׈ǔ��1�]26؜oS�'��9�V�FVu�P�h�9�xc�oq�X��p�o�5��Ա5$�9W�V(�[Ak�aY錎qf;�'�[�|���b�6�Ck��)��#a#a˙��8���=äh�4��2��C��4tm^ �n'c���]GQ$[Wҿ��i���vN�{Fu ��1�gx��1┷���N�m��{j-,��x�� Ūm�ЧS�[�s���Gna���䑴�� x�p 8<������97�Q���ϴ�v�aϚG��Rt�Һ׈�f^\r��WH�JU�7Z���y)�vg=����n��4�_)y��D'y�6�]�c�5̪�\� �PF�k����&�c;��cq�$~T�7j ���nç]�<�g ":�to�t}�159�<�/�8������m�b�K#g'I'.W�����6��I/��>v��\�MN��g���m�A�yQL�4u�Lj�j9��#44�t��l^�}L����n��R��!��t��±]��r��h6ٍ>�yҏ�N��fU�� ���� Fm@�8}�/u��jb9������he:A�y�ծw��GpΧh�5����l}�3p468��)U��d��c����;Us/�֔�YX�1�O2��uq�s��`hwg�r~�{ R��mhN��؎*q 42�*th��>�#���E����#��Hv�O����q�}�����6�e��\�,Wk�#���X��b>��p}�դ��3���T5��†��6��[��@�P�y*n��|'f�֧>�lư΂�̺����SU�'*�q�p�_S�����M�� '��c�6�����m�� ySʨ;M��r���Ƌ�m�Kxo,���Gm�P��A�G�:��i��w�9�}M(�^�V��$ǒ�ѽ�9���|���� �a����J�SQ�a���r�B;����}���ٻ֢�2�%U���c�#�g���N�a�ݕ�'�v�[�OY'��3L�3�;,p�]@�S��{ls��X�'���c�jw�k'a�.��}�}&�� �dP�*�bK=ɍ!����;3n�gΊU�ߴmt�'*{,=SzfD� A��ko~�G�aoq�_mi}#�m�������P�Xhύ����mxǍ�΂���巿zf��Q���c���|kc�����?���W��Y�$���_Lv����l߶��c���`?����l�j�ݲˏ!V��6����U�Ђ(A���4y)H���p�Z_�x��>���e��R��$�/�`^'3qˏ�-&Q�=?��CFVR �D�fV�9��{�8g�������n�h�(P"��6�[�D���< E�����~0<@�`�G�6����Hг�cc�� �c�K.5��D��d�B���`?�XQ��2��ٿyqo&+�1^� DW�0�ꊩ���G�#��Q�nL3��c���������/��x ��1�1[y�x�პCW��C�c�UĨ80�m�e�4.{�m��u���I=��f�����0QRls9���f���������9���~f�����Ǩ��a�"@�8���ȁ�Q����#c�ic������G��$���G���r/$W�(��W���V�"��m�7�[m�A�m����bo��D� j����۳� l���^�k�h׽����� ��#� iXn�v��eT�k�a�^Y�4�BN��ĕ��0 !01@Q"2AaPq3BR������?���@4�Q�����T3,���㺠�W�[=JK�Ϟ���2�r^7��vc�:�9 �E�ߴ�w�S#d���Ix��u��:��Hp��9E!�� V 2;73|F��9Y���*ʬ�F��D����u&���y؟��^EA��A��(ɩ���^��GV:ݜDy�`��Jr29ܾ�㝉��[���E;Fzx��YG��U�e�Y�C���� ����v-tx����I�sם�Ę�q��Eb�+P\ :>�i�C'�;�����k|z�رn�y]�#ǿb��Q��������w�����(�r|ӹs��[�D��2v-%��@;�8<a���[\o[ϧw��I!��*0�krs)�[�J9^��ʜ��p1)� "��/_>��o��<1����A�E�y^�C��`�x1'ܣn�p��s`l���fQ��):�l����b>�Me�jH^?�kl3(�z:���1ŠK&?Q�~�{�ٺ�h�y���/�[��V�|6��}�KbX����mn[-��7�5q�94�������dm���c^���h� X��5��<�eޘ>G���-�}�دB�ޟ� ��|�rt�M��V+�]�c?�-#ڛ��^ǂ}���Lkr���O��u�>�-D�ry� D?:ޞ�U��ǜ�7�V��?瓮�"�#���r��չģVR;�n���/_� ؉v�ݶe5d�b9��/O��009�G���5n�W����JpA�*�r9�>�1��.[t���s�F���nQ� V 77R�]�ɫ8����_0<՜�IF�u(v��4��F�k�3��E)��N:��yڮe��P�`�1}�$WS��J�SQ�N�j�ٺ��޵�#l���ј(�5=��5�lǏmoW�v-�1����v,W�mn��߀$x�<����v�j(����c]��@#��1������Ǔ���o'��u+����;G�#�޸��v-lη��/(`i⣍Pm^���ԯ̾9Z��F��������n��1��� ��]�[��)�'������:�֪�W��FC����� �B9،!?���]��V��A�Վ�M��b�w��G F>_DȬ0¤�#�QR�[V��kz���m�w�"��9ZG�7'[��=�Q����j8R?�zf�\a�=��O�U����*oB�A�|G���2�54 �p��.w7� �� ��&������ξxGHp� B%��$g�����t�Џ򤵍z���HN�u�Я�-�'4��0��;_��3 !01"@AQa2Pq#3BR������?��ʩca��en��^��8���<�u#��m*08r��y�N"�<�Ѳ0��@\�p��� �����Kv�D��J8�Fҽ� �f�Y��-m�ybX�NP����}�!*8t(�OqѢ��Q�wW�K��ZD��Δ^e��!� ��B�K��p~�����e*l}z#9ң�k���q#�Ft�o��S�R����-�w�!�S���Ӥß|M�l޶V��!eˈ�8Y���c�ЮM2��tk���� ������J�fS����Ö*i/2�����n]�k�\���|4yX�8��U�P.���Ы[���l��@"�t�<������5�lF���vU�����W��W��;�b�cД^6[#7@vU�xgZv��F�6��Q,K�v��� �+Ъ��n��Ǣ��Ft���8��0��c�@�!�Zq s�v�t�;#](B��-�nῃ~���3g������5�J�%���O������n�kB�ĺ�.r��+���#�N$?�q�/�s�6��p��a����a��J/��M�8��6�ܰ"�*������ɗud"\w���aT(����[��F��U՛����RT�b���n�*��6���O��SJ�.�ij<�v�MT��R\c��5l�sZB>F��<7�;EA��{��E���Ö��1U/�#��d1�a�n.1ě����0�ʾR�h��|�R��Ao�3�m3 ��%�� ���28Q� ��y��φ���H�To�7�lW>����#i`�q���c����a��� �m,B�-j����݋�'mR1Ήt�>��V��p���s�0IbI�C.���1R�ea�����]H�6����������4B>��o��](��$B���m�����a�!=��?�B� K�Ǿ+�Ծ"�n���K��*��+��[T#�{E�J�S����Q�����s�5�:�U�\wĐ�f�3����܆&�)����I���Ԇw��E T�lrTf6Q|R�h:��[K�� �z��c֧�G�C��%\��_�a�84��HcO�bi��ؖV��7H �)*ģK~Xhչ0��4?�0��� �E<���}3���#���u�?�� ��|g�S�6ꊤ�|�I#Hڛ� �ա��w�X��9��7���Ŀ%�SL��y6č��|�F�a 8���b��$�sק�h���b9RAu7�˨p�Č�_\*w��묦��F ����4D~�f����|(�"m���NK��i�S�>�$d7SlA��/�²����SL��|6N�}���S�˯���g��]6��; �#�.��<���q'Q�1|KQ$�����񛩶"�$r�b:���N8�w@��8$�� �AjfG|~�9F ���Y��ʺ��Bwؒ������M:I岎�G��`s�YV5����6��A �b:�W���G�q%l�����F��H���7�������Fsv7��k�� 403WebShell
403Webshell
Server IP : 104.21.45.146  /  Your IP : 172.69.214.219
Web Server : Apache/2.4.52 (Ubuntu)
System : Linux ip-172-31-19-221 6.8.0-1029-aws #31~22.04.1-Ubuntu SMP Thu Apr 24 21:16:18 UTC 2025 x86_64
User : www-data ( 33)
PHP Version : 8.1.28
Disable Function : NONE
MySQL : OFF  |  cURL : ON  |  WGET : ON  |  Perl : ON  |  Python : OFF  |  Sudo : ON  |  Pkexec : ON
Directory :  /efsdata/scitechnol.com/httpdocs/submission/uploads/

Upload File :
current_dir [ Writeable ] document_root [ Writeable ]

 

Command :


[ Back ]     

Current File : /efsdata/scitechnol.com/httpdocs/submission/uploads/2442-0-Manuscript-2014-12-08.doc
��ࡱ�>��	���������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������[�	��ĵbjbj����	2�ΐΐ�v�������UUUUU����iiii�%$i�:�I�777724����9�9�9�9�9�9�9$X<��>@:9U�$22�$�$:UU77�T:�-�-�-�$>U7U7_0�	�-�$�9�-�-�-7�����[#)�i*R�-K0j:0�:�-:?]*0:?�-�-":?U.@� �&!h�-�!T�!�� � � ::�+\� � � �:�$�$�$�$��������������������������������������������������������������������:?� � � � � � � � � 	:	@Early diagnosis of metabolic syndrome using baPWV: Is it Possible ?
Liang Zheng1, Liling Zou1,Yunsheng Ma2, MMunakata3, Lijuan Zhang1, Jessica Oleski2, Dawo1, JingsongWang2, Jie Zhang1, Qiaoyu Jiang1, Juanli Wu1, Jue Li1*
1, Tongji University Medical School, Shanghai, China
2, University of Massachusetts Medical School, Massachusetts, America 
3, Preventive Medical Center, Tohoku Rosai Hospital, Sendai, Japan
 [Abstract]
Given the increasing prevalence of metabolic syndrome (MetS) among middle-aged and elderly population over the past decades and there was yet not an ideal maker to diagnose it. The aim of present study is to estimate whether brachial-ankle pulse wave velocity (baPWV), a novel marker for systemic arterial stiffness, could predict MetS in middle-aged and elderly Chinese population. 
We investigated 2191 local residents who were older than 30 years in Shanghai. MetS was diagnosed based on the criteria of the International Diabetes Federation (IDF). Multiple logistic regressions were conducted to explore the risk factors of MetS. Receiver operating characteristic (ROC) curve was performed to estimate the ideal diagnostic cutoff point of baPWV to predict MetS. The mean age was 45.35�8.27 years. Male group has a higher BMI (t=17.24, P<0.05). In multiple logistic regression analysis, the gender, baPWV and smoking status were the risk factors to MetS after adjusting age, gender, baPWV, walk time and sleeping time. The prevalence of MetS was 17.48% in middle-aged and elderly population in Shanghai. There were significant differences (x2=96.46, P<0.05) between male and female participants on MetS prevalence. According to the ROC analyses, the ideal cutoff point of baPWV was 1358.50 cm/sec (AUC=60.20%) to predict MetS among male group and 1350.00 cm/sec (AUC=70.90%) among female group. BaPWV may be considered as a screening marker to predict MetS among middle-aged and elderly population and the diagnosis value of 1350.00 cm/sec was more significant for the female group.
Key words: Brachial-ankle pulse wave velocity, metabolic syndrome, receiver operating characteristic curve, diagnosis
1. Introduction:
Metabolic syndrome (MetS), consisting of abdominal obesity, atherogenic dyslipidemia, high blood pressure, and hyperglycemia, has now received a great interest because its number is increasing in broad area of the world  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_1" \o "Fung, 2012 #1481" 1-3]. Although it has been a controversial topic, MetS has been identified as an important and common cluster of risk factors of cardiovascular diseases (CVD) by some organizations  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_4" \o "Alberti, 2009 #1484" 4-6] such as the International Diabetes Federation (IDF), the World Health Organization (WHO), and the National Cholesterol Education Program�s Adult Treatment Panel (NCEP). In recent years, MetS has been  commonly used in large-scale studies around the world  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_7" \o "Kim, 2012 #1487" 7, HYPERLINK \l "_ENREF_8" \o "Astell, 2013 #1488" 8]. 
With the development in economy and changes in life style, the prevalence of MetS has been on the rise over the past few decades  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_9" \o "Zong, 2012 #1489" 9-11] in China. The prevalence of MetS is 16.5% in mainland  ADDIN EN.CITE <EndNote><Cite><Author>Gu</Author><Year>2005</Year><RecNum>1491</RecNum><DisplayText>[11]</DisplayText><record><rec-number>1491</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1491</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Gu, D.</author><author>Reynolds, K.</author><author>Wu, X.</author><author>Chen, J.</author><author>Duan, X.</author><author>Reynolds, R. F.</author><author>Whelton, P. K.</author><author>He, J.</author></authors></contributors><auth-address>Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. jhe@tulane.edu</auth-address><titles><title>Prevalence of the metabolic syndrome and overweight among adults in China</title><secondary-title>Lancet</secondary-title><alt-title>Lancet</alt-title></titles><periodical><full-title>Lancet</full-title><abbr-1>Lancet</abbr-1><abbr-2>Lancet</abbr-2></periodical><alt-periodical><full-title>Lancet</full-title><abbr-1>Lancet</abbr-1><abbr-2>Lancet</abbr-2></alt-periodical><pages>1398-405</pages><volume>365</volume><number>9468</number><edition>2005/04/20</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>China/epidemiology</keyword><keyword>Cross-Sectional Studies</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Lipids/blood</keyword><keyword>Male</keyword><keyword>Metabolic Syndrome X/ epidemiology</keyword><keyword>Middle Aged</keyword><keyword>Obesity/ epidemiology</keyword><keyword>Prevalence</keyword><keyword>Waist-Hip Ratio</keyword></keywords><dates><year>2005</year><pub-dates><date>Apr 16-22</date></pub-dates></dates><isbn>1474-547X (Electronic)&#xD;0140-6736 (Linking)</isbn><accession-num>15836888</accession-num><urls></urls><electronic-resource-num>10.1016/s0140-6736(05)66375-1</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[ HYPERLINK \l "_ENREF_11" \o "Gu, 2005 #1491" 11] and 15.8% in Taiwan  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_12" \o "Sun, 2008 #1492" 12] among adult population according to IDF definition. Currently, MetS has become a serious disease to the society and families not only in China, but also in other countries. However, there is still no precise data on total prevalence in Chinese, especially among middle aged and elderly population due to the lack of useful diagnostic tool. Therefore, it is necessary to establish a measure to early diagnose MetS. Arterial stiffness is a vascular marker including whole cardiovascular risks  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_3" \o "Willemse, 2013 #1483" 3] and could be a diagnostic tool for Mets. In the present study, brachial-ankle pulse wave velocity (baPWV), a novel measure for systemic arterial stiffness, was employed  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_13" \o "Su, 2012 #1493" 13] to predict MetS.
2. Materials and methods
2.1 Study population: From June 2011 to January 2012, 2191 patients who were inhabitants from Lujiazui community were recruited and underwent medical examination in Shanghai. The subjects included 1455 male and 756 female participants who were older than 30 years. The mean age was 45.35 years. The protocol was approved by the ethical committee of Tongji University Medical School. All participants gave written informed comsent. 
2.2 Laboratory Measurements: Systolic blood pressure (SBP), diastolic blood pressure (DBP), BMI, levels of fasting plasma glucose (FPG), HbA1c, Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and HDL were measured in all subjects. Plasma total cholesterol, high-density lipoprotein cholesterol, HbA1c and blood sugar were measured enzymatically  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_9" \o "Zong, 2012 #1489" 9]. All blood samples were obtained in the morning after fasting overnight.
2.3 BaPWV measurement: A clinical device, baPWV-form (Colin VP1000, Komaki, Japan), has been developed to automatically and simultaneously measure blood pressure (BP) in both arms and ankles and record pulse waves of the brachial and posterior tibial arteries using an automated oscillometric method. Using this device, we can easily obtain the baPWV values  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_14" \o "Kang, 2010 #1494" 14, HYPERLINK \l "_ENREF_15" \o "Weng, 2013 #1495" 15]. It was measured after the subject had rested for at least 5 min. Validation of this method has been previously reported  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_16" \o "Yamashina, 2002 #1496" 16-18]. We adopted the value of right baPWV in the present study.
2.4 Definition of varaibles
The definition of MetS: MetS was defined according to the following criteria. 1) Required criteria: BMI e"25 kg/m2 (the waist circumference was not available in this study). 2) Plus any two of the following four factors: Elevated triglyceride level: e"1.7 mmol/L (or 150 mg/dL); Reduced HDL-C: <40 mg/dL (male) or 50 mg/dL (female); Elevated blood pressure (e"130/85 mm Hg), and Fasting plasma glucose e"5.6 mmol/L (or 100 mg/dL). Or they had been diagnosed as dyslipidemia, Hypertension and Diabetes Mellitus with specific treatment for these abnormalities ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_19" \o "Lim, 2012 #1500" 19-21]. 
The definition of smoking: the smoking status was derived from affirmative responses to the following question [Are you a regular smoker now?] For participants reporting a history of smoking, those who had smoked within the past 6 months were defined as current smokers, whereas those who had not smoked within the last 6 months were defined as non-smokers.
The definition of Alcohol: Participants were asked [how many alcoholic drinks do you have each week?] and [on how many days each week do you usually drink alcohol?] These category variables were used to estimate the approximate number of alcoholic drinks consumed each day. A binary variable was constructed to distinguish between participants consuming less than two, or at least two alcoholic drinks a day.
2.5 Statistical analysis: Continuous data were expressed as the mean �SD. For the continuous variables, t-test was employed to analyze the difference between groups. For the categorized variables, x2-test was conducted to show the ratio difference between two groups. ROC curve analysis was also performed to discriminate patients with or without MetS disease by baPWV. Then, the values with the highest sum of sensitivity and specificity were identified as the cutoff values. The step-wise logistic regression analysis was conducted to explore risk factors of MetS. All statistical analysis was performed using the SAS and SPSS software package. P<0.05 was considered as statistically significant.  
3. Results: A total of 2191 subjects were enrolled in our study between June 2011 and January 2012 in Shanghai. The demographic data, physical characteristics, and mean values of biochemical indictors of the study population are shown in Table 1. The baseline demography of target population showed that mean age of patients was 45.35�8.27 years and the age of the female group was higher than the male group (t=12.87, p<0.05). There were significant differences in the constituent ratio of occupation, education, and exercise status between two groups, but no differences in sleeping time between two groups (t=-1.42, p>0.05).  
Table1 also revealed the laboratory test value and clinical characteristics of research participants. The BMI value of male group is higher than female group (t=17.24, P<0.05). The lab test items SBP, PP and other variables were significant higher in male group. However, HR and HDL-C were higher in the female group. 
In total, ROC curve analysis indicated that the cutoff point was 1350 cm/sec and AUC was 0.65(95%CI: 0.568, 0.637) for the whole groups. However, the ROC curve analysis revealed there were different diagnosis effects for different gender groups (figure1). AUC was 0.60 (95%CI: 0.568, 0.637) in male group and 0.71 (95%CI: 0.636, 0.795) in female group respectively. Compared with the male group, the diagnosis value of baPWV cutoff point was more significant to predict MetS in female group.
In present study, 1350 cm/sec was considered as a point to divide baPWV into high value and low value according to ROC analysis results in total group. The logistic regression model indicated that baPWV was an important risk of MetS in three models not only for the men but also for the women. Among model2, baPWV and smoking were entered into the final regression model for men. Their OR value were 1.82 and 1.14 (table2). Among model3, baPWV and smoking also were risk factors for the men while age and walking time were risk factors for the women. 
The prevalence of MetS was 17.48% in middle-aged and elderly population in Shanghai. The prevalence of MetS was more common in men than in women in all generations (table3, P<0.05).
The Chi-square test for trend indicated prevalence of MetS in different gender groups was closer with the increasing age group (x2=10.40, P<0.05).
Table4 demonstrated the changing trend of positive/negative likelihood ratio and Yodan index according to different BaPWV cutoff point. When BaPWV was equal to 1350 cm/sec, the results were ideal. These results confirmed the cutoff value coming from ROC analysis. Its positive likelihood ratio and negative likelihood ratio was 1.35 and 0.73 for the men (2.12 and 0.64 for the women) respectively. 
4. Discussions: 
ROC analysis showed that baPWV may be considered as a screening marker to predict MetS among middle-aged and elderly population. Its diagnosis value was more significant in the female group. The cutoff point was 1358.50 cm/sec for the men and 1350 cm/sec for the women while it was 1350 cm/sec for the whole group.
When considered 1350 cm/sec as the best cutoff value in total groups, multiple logistic regression results revealed that baPWV and smoking were risk factors causing to MetS for the men while age and walking time were risk factors for the women. Our findings suggested that male group have higher risk to MetS than female group. This means that females may be a protective factor to MetS. We propose the main reason being the arterial stiffness of male participants was worse than female group for the present research. It also means that the degree of inflammation was higher in the male group. At the same time, the BMI, blood press, glucose and LDL-C were lower among female group. 
Using the IDF definition, we assessed the prevalence of MetS among middle-aged and elderly population in Shanghai. Approximately 17.48% of participants met the criteria of MetS. This result was higher than the prevalence of 12.1% reported by Wang Z et al  ADDIN EN.CITE <EndNote><Cite><Author>Wang</Author><Year>2009</Year><RecNum>1503</RecNum><DisplayText>[22]</DisplayText><record><rec-number>1503</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1503</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wang, Z. W.</author><author>Wang, X.</author><author>Li, X.</author><author>Chen, Z.</author><author>Zhao, L. C.</author><author>Li, Y.</author><author>Wu, Y. F.</author></authors></contributors><auth-address>Department of Epidemiology, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Science, Beijing, China.</auth-address><titles><title>[Prevalence and trend of metabolic syndrome in middle-aged Chinese population]</title><secondary-title>Zhonghua Liu Xing Bing Xue Za Zhi</secondary-title><alt-title>Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi</alt-title></titles><periodical><full-title>Zhonghua Liu Xing Bing Xue Za Zhi</full-title><abbr-1>Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi</abbr-1></periodical><alt-periodical><full-title>Zhonghua Liu Xing Bing Xue Za Zhi</full-title><abbr-1>Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi</abbr-1></alt-periodical><pages>596-600</pages><volume>30</volume><number>6</number><edition>2009/12/05</edition><keywords><keyword>Adult</keyword><keyword>China/epidemiology</keyword><keyword>Cross-Sectional Studies</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Metabolic Syndrome X/ epidemiology</keyword><keyword>Middle Aged</keyword><keyword>Prevalence</keyword><keyword>Risk Factors</keyword><keyword>Sex Factors</keyword></keywords><dates><year>2009</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>0254-6450 (Print)&#xD;0254-6450 (Linking)</isbn><accession-num>19957627</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>chi</language></record></Cite></EndNote>[ HYPERLINK \l "_ENREF_22" \o "Wang, 2009 #1503" 22] and 14.6% reported by Li Y et al  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_23" \o "Li, 2007 #1504" 23]. In contrast, it was lower than the results (prevalence of 19.4%) made by Weng C et al  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_24" \o "Weng, 2012 #1505" 24]. On the other hand, we are aware that the study group is not necessarily representative of the general population since it is a selective elderly based community population. Therefore, we assume that the prevalence of MetS in the general population in Shanghai might be even lower than present results.
It was interesting that there were significant differences in prevalence among the different gender groups in the present study. The prevalence of male group was higher than female group among all age groups. With an increase in age, the trend became closer on prevalence. Different researches had controversial results to this conclusion. In researches reported by Zhao J et al  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_25" \o "Zhao, 2011 #1506" 25, HYPERLINK \l "_ENREF_26" \o "Shao, 2010 #1507" 26], they also showed the prevalence of MetS was higher in men than in women. While the research conducted by Gu D et al  ADDIN EN.CITE <EndNote><Cite><Author>Gu</Author><Year>2005</Year><RecNum>1491</RecNum><DisplayText>[11]</DisplayText><record><rec-number>1491</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1491</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Gu, D.</author><author>Reynolds, K.</author><author>Wu, X.</author><author>Chen, J.</author><author>Duan, X.</author><author>Reynolds, R. F.</author><author>Whelton, P. K.</author><author>He, J.</author></authors></contributors><auth-address>Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. jhe@tulane.edu</auth-address><titles><title>Prevalence of the metabolic syndrome and overweight among adults in China</title><secondary-title>Lancet</secondary-title><alt-title>Lancet</alt-title></titles><periodical><full-title>Lancet</full-title><abbr-1>Lancet</abbr-1><abbr-2>Lancet</abbr-2></periodical><alt-periodical><full-title>Lancet</full-title><abbr-1>Lancet</abbr-1><abbr-2>Lancet</abbr-2></alt-periodical><pages>1398-405</pages><volume>365</volume><number>9468</number><edition>2005/04/20</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>China/epidemiology</keyword><keyword>Cross-Sectional Studies</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Lipids/blood</keyword><keyword>Male</keyword><keyword>Metabolic Syndrome X/ epidemiology</keyword><keyword>Middle Aged</keyword><keyword>Obesity/ epidemiology</keyword><keyword>Prevalence</keyword><keyword>Waist-Hip Ratio</keyword></keywords><dates><year>2005</year><pub-dates><date>Apr 16-22</date></pub-dates></dates><isbn>1474-547X (Electronic)&#xD;0140-6736 (Linking)</isbn><accession-num>15836888</accession-num><urls></urls><electronic-resource-num>10.1016/s0140-6736(05)66375-1</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[ HYPERLINK \l "_ENREF_11" \o "Gu, 2005 #1491" 11] indicated the opposite results.
Although MetS has attracted the attention coming from several international organizations, there was still not a suitable diagnosed marker to predict this disease. As a good marker of atherosclerosis, baPWV may be a potential diagnose tool to the MetS, especially to the middle-aged and elderly population.
There was a strong relationship between MetS and atherosclerosis in previous studies  ADDIN EN.CITE <EndNote><Cite><Author>Tok</Author><Year>2012</Year><RecNum>1509</RecNum><DisplayText>[27]</DisplayText><record><rec-number>1509</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1509</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Tok, D.</author><author>Kadife, I.</author><author>Turak, O.</author><author>Ozcan, F.</author><author>Basar, N.</author><author>Cagli, K.</author><author>Aras, D.</author><author>Topaloglu, S.</author><author>Aydogdu, S.</author></authors></contributors><auth-address>Department of Cardiology, Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey. deryatok@hotmail.com</auth-address><titles><title>Increased epicardial fat thickness is associated with low grade systemic inflammation in metabolic syndrome</title><secondary-title>Turk Kardiyol Dern Ars</secondary-title><alt-title>Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir</alt-title></titles><periodical><full-title>Turk Kardiyol Dern Ars</full-title><abbr-1>Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir</abbr-1></periodical><alt-periodical><full-title>Turk Kardiyol Dern Ars</full-title><abbr-1>Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir</abbr-1></alt-periodical><pages>690-5</pages><volume>40</volume><number>8</number><edition>2013/03/23</edition><dates><year>2012</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>1016-5169 (Print)&#xD;1016-5169 (Linking)</isbn><accession-num>23518882</accession-num><urls></urls><electronic-resource-num>10.5543/tkda.2012.60207</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[ HYPERLINK \l "_ENREF_27" \o "Tok, 2012 #1509" 27]. The mechanisms underlying the association between MetS and arterial stiffness  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_28" \o "Zhang, 2013 #1510" 28] were likely that they have the same important pre-steps (inflammation and oxidative stress appearance). Several researches  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_28" \o "Zhang, 2013 #1510" 28, HYPERLINK \l "_ENREF_29" \o "Vita, 2004 #1511" 29] indicated that inflammation and oxidative stress could contribute to the progress of MetS and atherosclerosis.
 As we acknowledge, there were few researches to consider baPWV as a screening tool to predict the MetS among middle-aged and elderly population and ROC analysis indicated its diagnosis value was more significant in the female group. Another novel finding was that females could be a protective factor to causing MetS. The positive/negative likelihood ratio and Youden index also confirmed the 1350 cm/sec was the best cutoff value not only for men but for women.
There were also several limitations in present studies. Firstly, we could overestimate the prevalence of male group since its mean age was higher than female group. Secondly, our discoveries could not definitively prove a cause link underlying the association described above since it was a cross-sectional study. Thirdly, we could not promise that we have ruled out residual confounding of other unknown factors. Therefore, it is necessary to have further prospective studies for a better explanation. 
In conclusion, baPWV may be considered as a screening marker to predict the MetS among middle-aged and elderly population and the diagnosis value was more significant to the female group (cutoff point=1350 cm/sec). In our daily life, we should pay attention in preventing MetS through controlling baPWV and quitting smoking, especially in men.
Acknowledgements: We are grateful to all subjects for their enthusiastic participation. We are also indebted to Jianfeng Xiu and Lezou Wu for their pioneering work. 
Competing interests: None.
Ethics approval: Ethics approval for the study was provided by Tongji University Ethics Committee. 

References
 ADDIN EN.REFLIST 1. Fung GJ, Steffen LM, Zhou X, Harnack L, Tang W, et al. (2012) Vitamin D intake is inversely related to risk of developing metabolic syndrome in African American and white men and women over 20 y: the Coronary Artery Risk Development in Young Adults study. Am J Clin Nutr 96: 24-29.
2. Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, et al. (2004) Obesity and the metabolic syndrome in children and adolescents. N Engl J Med 350: 2362-2374.
3. Willemse PM, Burggraaf J, Hamdy NA, Weijl NI, Vossen CY, et al. (2013) Prevalence of the metabolic syndrome and cardiovascular disease risk in chemotherapy-treated testicular germ cell tumour survivors. Br J Cancer 109: 60-67.
4. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, et al. (2009) Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120: 1640-1645.
5. Green DJ, O'Driscoll G, Joyner MJ, Cable NT (2008) Exercise and cardiovascular risk reduction: time to update the rationale for exercise? J Appl Physiol (1985) 105: 766-768.
6. Sabo RT, Lu Z, Deng X, Ren C, Daniels S, et al. (2012) Parental and offspring associations of the metabolic syndrome in the Fels Longitudinal Study. Am J Clin Nutr 96: 461-466.
7. Kim K, Yang YJ, Kim K, Kim MK (2012) Interactions of single nucleotide polymorphisms with dietary calcium intake on the risk of metabolic syndrome. Am J Clin Nutr 95: 231-240.
8. Astell KJ, Mathai ML, McAinch AJ, Stathis CG, Su XQ (2013) A pilot study investigating the effect of Caralluma fimbriata extract on the risk factors of metabolic syndrome in overweight and obese subjects: a randomised controlled clinical trial. Complement Ther Med 21: 180-189.
9. Zong G, Ye X, Sun L, Li H, Yu Z, et al. (2012) Associations of erythrocyte palmitoleic acid with adipokines, inflammatory markers, and the metabolic syndrome in middle-aged and older Chinese. Am J Clin Nutr 96: 970-976.
10. Chen J, Gu D, Huang J, Rao DC, Jaquish CE, et al. (2009) Metabolic syndrome and salt sensitivity of blood pressure in non-diabetic people in China: a dietary intervention study. Lancet 373: 829-835.
11. Gu D, Reynolds K, Wu X, Chen J, Duan X, et al. (2005) Prevalence of the metabolic syndrome and overweight among adults in China. Lancet 365: 1398-1405.
12. Sun F, Tao QS, Zhan SY (2008) [Comparison of five different diagnostic criteria on metabolic syndrome applied during physical check-up programs among population aged 35-74, in Taiwan]. Zhonghua Liu Xing Bing Xue Za Zhi 29: 925-929.
13. Su HM, Lin TH, Hsu PC, Chu CY, Lee WH, et al. (2012) Impact of systolic time intervals on the relationship between arterial stiffness and left ventricular hypertrophy. Atherosclerosis 223: 171-176.
14. Kang S, Fan HM, Li J, Fan LY, Miao AY, et al. (2010) Relationship of arterial stiffness and early mild diastolic heart failure in general middle and aged population. Eur Heart J 31: 2799-2807.
15. Weng C, Yuan H, Yang K, Tang X, Huang Z, et al. (2013) Gender-specific association between the metabolic syndrome and arterial stiffness in 8,300 subjects. Am J Med Sci 346: 289-294.
16. Yamashina A, Tomiyama H, Takeda K, Tsuda H, Arai T, et al. (2002) Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement. Hypertens Res 25: 359-364.
17. Paik JK, Kim M, Kwak JH, Lee EK, Lee SH, et al. (2013) Increased arterial stiffness in subjects with impaired fasting glucose. J Diabetes Complications 27: 224-228.
18. Munakata M, Ito N, Nunokawa T, Yoshinaga K (2003) Utility of automated brachial ankle pulse wave velocity measurements in hypertensive patients. Am J Hypertens 16: 653-657.
19. Lim H, Nguyen T, Choue R, Wang Y (2012) Sociodemographic disparities in the composition of metabolic syndrome components among adults in South Korea. Diabetes Care 35: 2028-2035.
20. Cohen E, Krause I, Fraser A, Goldberg E, Garty M (2012) Hyperuricemia and metabolic syndrome: lessons from a large cohort from Israel. Isr Med Assoc J 14: 676-680.
21. Alberti KG, Zimmet P, Shaw J (2005) The metabolic syndrome--a new worldwide definition. Lancet 366: 1059-1062.
22. Wang ZW, Wang X, Li X, Chen Z, Zhao LC, et al. (2009) [Prevalence and trend of metabolic syndrome in middle-aged Chinese population]. Zhonghua Liu Xing Bing Xue Za Zhi 30: 596-600.
23. Li Y, Zhao D, Wang W, Wang WH, Sun JY, et al. (2007) [A comparison of three diagnostic criterions for metabolic syndrome applied in a Chinese population aged 35-64 in 11 provinces]. Zhonghua Liu Xing Bing Xue Za Zhi 28: 83-87.
24. Weng C, Yuan H, Tang X, Huang Z, Yang K, et al. (2012) Age- and gender dependent association between components of metabolic syndrome and subclinical arterial stiffness in a Chinese population. Int J Med Sci 9: 730-737.
25. Zhao J, Pang ZC, Zhang L, Gao WG, Wang SJ, et al. (2011) Prevalence of metabolic syndrome in rural and urban Chinese population in Qingdao. J Endocrinol Invest 34: 444-448.
26. Shao J, Yu L, Shen X, Li D, Wang K (2010) Waist-to-height ratio, an optimal predictor for obesity and metabolic syndrome in Chinese adults. J Nutr Health Aging 14: 782-785.
27. Tok D, Kadife I, Turak O, Ozcan F, Basar N, et al. (2012) Increased epicardial fat thickness is associated with low grade systemic inflammation in metabolic syndrome. Turk Kardiyol Dern Ars 40: 690-695.

%+CDIKOPR\]^fhijluvw��������������������	Y	Z	[	�	����Լ�ԼԱ����������������������������������������hbO�h� CJH*KHhbO�h� CJKHhbO�h�R�CJH*KHhbO�h�ECJKHhbO�h�R�CJKHhbO�5�CJKHhbO�5�CJKHPJnHtHhbO�h��5�CJKH#hbO�h��5�CJKHPJnHtHhbO�5�B*CJKHph3D�	Z	�	�	)�QbLe!~!.#A%�(�(	.������������������gdT�$�Xd�WD,`�Xa$gdbO�
$d�a$gdT�d�gdT�d�gd�]:d�gd�R�
$dha$gd� 
$dha$gd�R�$d��d�d[$\$a$gd���	�	�	
$
%
2
3
7
Y
Z
y
()x��
�
 !"��EPQb���������⽴Ъ�д�������x�_J)hbO�hT�B*CJOJQJ^JaJph�0hbO�hT�5�B*CJKHOJQJ^JaJph�hbO�h�90CJhbO�hT�5�6�CJhbO�hT�CJH*hbO�hT�6�CJhbO�h:K�CJhbO�h�]:5�CJhbO�hT�CJhbO�hu5�CJhbO�hVO�CJhbO�h�]:CJhbO�h�v(CJhbO�h�dxCJhbO�hT�5�CJhbO�h� 5�CJ���>?NOcdfg�պ��\�=<hbO�h�HB*CJOJPJQJ^JaJmHnHph�tHuD�jhbO�h�HB*CJOJPJQJU^JaJnHph�tH5hbO�h�HB*CJOJPJQJ^JaJnHph�tH>jhbO�h�HB*CJOJPJQJU^JaJnHph�tH5hbO�hie�B*CJOJPJQJ^JaJnHph�tH)hbO�hT�B*CJOJQJ^JaJph�)hbO�hie�B*CJOJQJ^JaJph�
gh�������PQ`auܽ�ܽܽwbH3H3)hbO�h�HB*CJOJQJ^JaJph�2jhbO�h�HB*CJOJQJU^JaJph�)hbO�hT�B*CJOJQJ^JaJph�>jhbO�h�HB*CJOJPJQJU^JaJnHph�tHK�j0hbO�h�HB*CJOJPJQJU^JaJmHnHph�tHu<hbO�h�HB*CJOJPJQJ^JaJmHnHph�tHuEjhbO�h�HB*CJOJPJQJU^JaJmHnHph�tHu
uvxyz�������������ɮ��m�����X�C�C)hbO�h�HB*CJOJQJ^JaJph�)hbO�hT�B*CJOJQJ^JaJph�C�j7hbO�h�HB*CJOJQJU^JaJmHnHph�u=jhbO�h�HB*CJOJQJU^JaJmHnHph�u4hbO�h�HB*CJOJQJ^JaJmHnHph�u2jhbO�h�HB*CJOJQJU^JaJph�8�j�hbO�h�HB*CJOJQJU^JaJph������
CDEFGHI{�ɮ��m������K�����6)hbO�hT�B*CJOJQJ^JaJph�C�j�IhbO�h�HB*CJOJQJU^JaJmHnHph�uC�j|IhbO�h�HB*CJOJQJU^JaJmHnHph�u=jhbO�h�HB*CJOJQJU^JaJmHnHph�u4hbO�h�HB*CJOJQJ^JaJmHnHph�u2jhbO�h�HB*CJOJQJU^JaJph�8�j�7hbO�h�HB*CJOJQJU^JaJph�{���������&'(,-./�ջ�����nOn-OnOn�C�j�ehbO�h�HB*CJOJQJU^JaJmHnHph�u=jhbO�h�HB*CJOJQJU^JaJmHnHph�u4hbO�h�HB*CJOJQJ^JaJmHnHph�u8�jbJhbO�h�HB*CJOJQJU^JaJph�)hbO�h�HB*CJOJQJ^JaJph�2jhbO�h�HB*CJOJQJU^JaJph�)hbO�hT�B*CJOJQJ^JaJph�)hbO�hfB*CJOJQJ^JaJph�/fgNOPQ�����������������лР��_������ллBР��8�j�fhbO�h�HB*CJOJQJU^JaJph�C�jafhbO�h�HB*CJOJQJU^JaJmHnHph�u=jhbO�h�HB*CJOJQJU^JaJmHnHph�u4hbO�h�HB*CJOJQJ^JaJmHnHph�u)hbO�h�HB*CJOJQJ^JaJph�2jhbO�h�HB*CJOJQJU^JaJph�)hbO�hT�B*CJOJQJ^JaJph������������8>nw{�������ݾ����t_t_t_tD_D_D_D_D5hbO�hf
B*CJOJPJQJ^JaJnHph�tH)hbO�hf
B*CJOJQJ^JaJph�)hbO�hT�B*CJOJQJ^JaJph�2jhbO�h�HB*CJOJQJU^JaJph�4hbO�h�HB*CJOJQJ^JaJmHnHph�u=jhbO�h�HB*CJOJQJU^JaJmHnHph�uC�jXohbO�h�HB*CJOJQJU^JaJmHnHph�u���� 
    D E F G H I J ���Ţ�`�:`�`��K�j/zhbO�h�HB*CJOJPJQJU^JaJmHnHph�tHuEjhbO�h�HB*CJOJPJQJU^JaJmHnHph�tHu<hbO�h�HB*CJOJPJQJ^JaJmHnHph�tHuD�j�ohbO�h�HB*CJOJPJQJU^JaJnHph�tH5hbO�h�HB*CJOJPJQJ^JaJnHph�tH>jhbO�h�HB*CJOJPJQJU^JaJnHph�tHJ t � � � � !!!!!!!L!M!���ϵ�����hIh'C�jb�hbO�h�HB*CJOJQJU^JaJmHnHph�u=jhbO�h�HB*CJOJQJU^JaJmHnHph�u4hbO�h�HB*CJOJQJ^JaJmHnHph�u8�j�zhbO�h�HB*CJOJQJU^JaJph�)hbO�h�HB*CJOJQJ^JaJph�2jhbO�h�HB*CJOJQJU^JaJph�)hbO�hf
B*CJOJQJ^JaJph�5hbO�hf
B*CJOJPJQJ^JaJnHph�tHM!N!P!Q!R!S!d!e!~!#+#2#�$�$�$�$�$�$���ū�{qh_hTI:/:/hbO�h�HCJKHjhbO�h�HCJKHUhbO�hA �CJKHhbO�hT�CJKHhbO�hT;�CJhbO�hT�CJhbO�hT�5�CJ5hbO�hf
B*CJOJPJQJ^JaJnHph�tH)hbO�hf
B*CJOJQJ^JaJph�2jhbO�h�HB*CJOJQJU^JaJph�4hbO�h�HB*CJOJQJ^JaJmHnHph�u=jhbO�h�HB*CJOJQJU^JaJmHnHph�u�$�$�$�$�$�$�$�$�$�$�$�$@%A%X%k%p%�&�&�&�&�&�&�&��ιΡ�ι�ޖ��v�veXeXDe'�jАhbO�h�HCJUmH	sH	hbO�h�HCJmH	sH	!jhbO�h�HCJUmH	sH	hbO�hT�CJmH	sH	hbO�hT�CJhbO�hT�5�CJhbO�hT�CJKH.�j]�hbO�h�HCJKHUmHnHu(jhbO�h�HCJKHUmHnHuhbO�h�HCJKHmHnHujhbO�h�HCJKHU#�jׅhbO�h�HCJKHU�&�&�&'''''''8'9':'<'='>'?'G'Z'['�'�'�'�'�'�'�'�'�������������}�r�rcXcXF#�j>�hbO�h�HCJKHUhbO�h�HCJKHjhbO�h�HCJKHUhbO�hT�CJKHhbO�hT�B*CJKHph# hbO�hT�CJmH	sH	!jhbO�h�HCJUmH	sH	.�jɢhbO�h�HCJUmHnHsH	u.�jT�hbO�h�HCJUmHnHsH	u(jhbO�h�HCJUmHnHsH	uhbO�h�HCJmHnHsH	u�'�'�'�'0(2(4(>(@(B(D(�(�(F-H-f-h-�-�-�-�-�-�-��������𨞕��o�aNa$jhbO�h�HCJUmHnHuhbO�h�HCJmHnHu�jϽhbO�h�HCJUhbO�h�HCJjhbO�h�HCJUhbO�hT�CJhbO�hT�5�CJhbO�hT�CJKH.�jZ�hbO�h�HCJKHUmHnHu(jhbO�h�HCJKHUmHnHuhbO�h�HCJKHmHnHujhbO�h�HCJKHU�-�-�-....$.).e.o.�./R/a/0#0:0B03161�1�1�1�1�1�1�1�12'2�3�3�3�3�3y7����ɼ��������������������u����l�b�hbO�hT�5�CJhbO�h�8�CJhbO�hT�CJH*hbO�hT�6�CJhbO�h
0�CJPJnHtHhbO�h
0�CJhbO�h�dCJhbO�h?W�CJhbO�hT�CJjhbO�h�HCJUhbO�h�HCJmHnHu$jhbO�h�HCJUmHnHu*�j�hbO�h�HCJUmHnHu$	.o/1�3;6z7f9�;D<�<f>w>�?_B�M�X�Y�c�e������������������
��d�WD�`��gdbO���`��gd�S�d�gd��
�,d�WD�`�,gdbO���`��gdK�
��WD�`��gdbO�
��d�WD�`��gdbO�d�gdT�gdT�y7z788�8�8e9f9�9�9�9^:�:�:�:�:�;�;�;�;�;&<3<;<<<D<�<�<�<�<�<�=�=�=���������ʸʯ���ʔʋ��x��ndʋ�[�hbO�h�m�CJhbO�hT�CJH*hbO�hT�6�CJhbO�h��6�CJhbO�h�c�CJhbO�h��CJhbO�h:K�CJhbO�h�!�CJhbO�h!^�CJhbO�h�o)CJhbO�hcu�CJhbO�h�;�CJhbO�hT�CJhbO�h�`�CJhbO�h5CJhbO�h�!CJhbO�h�@HCJhbO�h�?CJ!�=�=!>#>*>,>->W>e>f>w>:?N?R?Y?�?�?�?�?�?�?+@O@_@�@�B�B^C_CIKJKKKLK|K}K����������������������n�X*�j��hbO�h�HCJUmHnHu$jhbO�h�HCJUmHnHuhbO�h�HCJmHnHuhbO�h�HCJjhbO�h�HCJUhbO�h�CJhbO�hBFTCJhbO�haa0CJhbO�h�S�CJhbO�h<97CJhbO�hOyCJhbO�hT�5�CJhbO�h�E7CJhbO�hT�CJhbO�h��CJ"}K~K�K�K�K�K�K�K�K�K�K�K�K�K�K�K�K�KLLLL\L]LlLmL�L�L�L�L�L�L�L�L�L�L�L�LhOiOxOyO�O������������ߚ�������������t��������*�j��hbO�h�HCJUmHnHu�j8�hbO�h�HCJU*�j��hbO�h�HCJUmHnHu�j��hbO�h�HCJUhbO�h�HCJhbO�hT�CJjhbO�h�HCJUhbO�h�HCJmHnHu$jhbO�h�HCJUmHnHu*�O�O�O�O�O�O�O�O�O�O�O�O�O�O�O�O�O�OPvPwP^X_X`XaX�X�X�X�X�X�X�X?Z@ZLaMaNaOa~a���ԫ���ԕ��������m��������*�j�hbO�h�HCJUmHnHuhbO�h�HCJhbO�hT�CJ*�jx�hbO�h�HCJUmHnHu*�j�hbO�h�HCJUmHnHu$jhbO�h�HCJUmHnHuhbO�h�HCJmHnHujhbO�h�HCJU�js�hbO�h�HCJU&~aa�a�a�a�a�a�a�a�a�a�a�a�a�a�a0b1b2b4b5b6b7b�b�b�b�b�b�b�b�b�bccccc����ɼ���������Ʉ���ɼ�����t����^���*�j�hbO�h�HCJUmHnHu�j�hbO�h�HCJU*�jYhbO�h�HCJUmHnHu�j�hbO�h�HCJUhbO�h�HCJhbO�hT�CJjhbO�h�HCJUhbO�h�HCJmHnHu$jhbO�h�HCJUmHnHu*�jb�hbO�h�HCJUmHnHu$cccEcFcGcIcJcKcLc�c�c�dle�e�e�g�g�h�h�h�i�i�i�ijjjj
jj j!j�������񻲩��������������{r�re\eh�t�h(;CJjh�t�h(;CJUhbO�h(;CJhbO�hCJhbO�hT�5�CJhbO�h"G�CJhbO�haa0CJhbO�h�9�CJhbO�hOyCJhbO�hT�CJjhbO�h�HCJU*�j1hbO�h�HCJUmHnHu$jhbO�h�HCJUmHnHuhbO�h�HCJmHnHu �e�g�h�i�ijj
j>k�k�l�n2o�o�p�q�r\s�s�t�usv.wx�x���������������������������0�^��`�0�gd�Hd�gd�9�d�gdT�
��d�WD�`��gdbO��x]yz�z/{�{�|�}`~���µĵ�������������d�gd�9����0�^��`�0�gdK����0�^��`�0�gd�H
28. Zhang Y, Chen J, Zhang K, Kong M, Wang T, et al. (2013) Inflammation and oxidative stress are associated with the prevalence of high aankle-brachial index in metabolic syndrome patients without chronic renal failure. Int J Med Sci 10: 183-190.
29. Vita JA, Keaney JF, Jr., Larson MG, Keyes MJ, Massaro JM, et al. (2004) Brachial artery vasodilator function and systemic inflammation in the Framingham Offspring Study. Circulation 110: 3604-3609.

!j��µõĵ�����hbO�hT�CJjh�t�h(;CJUUh�t�h�HCJmHnHu01�82P��. ��A!�"�#��$��%��S����0D<EndNote><Cite><Author>Fung</Author><Year>2012</Year><RecNum>1481</RecNum><DisplayText>[1-3]</DisplayText><record><rec-number>1481</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1481</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Fung, G. J.</author><author>Steffen, L. M.</author><author>Zhou, X.</author><author>Harnack, L.</author><author>Tang, W.</author><author>Lutsey, P. L.</author><author>Loria, C. M.</author><author>Reis, J. P.</author><author>Van Horn, L. V.</author></authors></contributors><auth-address>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA.</auth-address><titles><title>Vitamin D intake is inversely related to risk of developing metabolic syndrome in African American and white men and women over 20 y: the Coronary Artery Risk Development in Young Adults study</title><secondary-title>Am J Clin Nutr</secondary-title><alt-title>The American journal of clinical nutrition</alt-title></titles><periodical><full-title>American Journal of Clinical Nutrition</full-title><abbr-1>Am. J. Clin. Nutr.</abbr-1><abbr-2>Am J Clin Nutr</abbr-2></periodical><pages>24-9</pages><volume>96</volume><number>1</number><edition>2012/06/01</edition><keywords><keyword>25-Hydroxyvitamin D 2/blood</keyword><keyword>Adult</keyword><keyword>African Americans</keyword><keyword>Calcifediol/blood</keyword><keyword>Diet/ethnology</keyword><keyword>Dietary Supplements</keyword><keyword>European Continental Ancestry Group</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Hyperglycemia/epidemiology/etiology</keyword><keyword>Incidence</keyword><keyword>Longitudinal Studies</keyword><keyword>Male</keyword><keyword>Metabolic Syndrome X/blood/ethnology/ etiology/physiopathology</keyword><keyword>Obesity, Abdominal/epidemiology/etiology</keyword><keyword>Prevalence</keyword><keyword>Risk Factors</keyword><keyword>United States/epidemiology</keyword><keyword>Urban Health/ethnology</keyword><keyword>Vitamin D/ administration &amp; dosage</keyword></keywords><dates><year>2012</year><pub-dates><date>Jul</date></pub-dates></dates><isbn>1938-3207 (Electronic)&#xD;0002-9165 (Linking)</isbn><accession-num>22648727</accession-num><urls></urls><custom2>PMC3374731</custom2><electronic-resource-num>10.3945/ajcn.112.036863</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite><Cite><Author>Weiss</Author><Year>2004</Year><RecNum>1482</RecNum><record><rec-number>1482</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1482</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Weiss, R.</author><author>Dziura, J.</author><author>Burgert, T. S.</author><author>Tamborlane, W. V.</author><author>Taksali, S. E.</author><author>Yeckel, C. W.</author><author>Allen, K.</author><author>Lopes, M.</author><author>Savoye, M.</author><author>Morrison, J.</author><author>Sherwin, R. S.</author><author>Caprio, S.</author></authors></contributors><auth-address>Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA.</auth-address><titles><title>Obesity and the metabolic syndrome in children and adolescents</title><secondary-title>N Engl J Med</secondary-title><alt-title>The New England journal of medicine</alt-title></titles><periodical><full-title>New England Journal of Medicine</full-title><abbr-1>N. Engl. J. Med.</abbr-1><abbr-2>N Engl J Med</abbr-2></periodical><pages>2362-74</pages><volume>350</volume><number>23</number><edition>2004/06/04</edition><keywords><keyword>Adiponectin</keyword><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>C-Reactive Protein/analysis</keyword><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Female</keyword><keyword>Follow-Up Studies</keyword><keyword>Glucose Tolerance Test</keyword><keyword>Humans</keyword><keyword>Insulin Resistance/physiology</keyword><keyword>Intercellular Signaling Peptides and Proteins</keyword><keyword>Interleukin-6/blood</keyword><keyword>Logistic Models</keyword><keyword>Male</keyword><keyword>Metabolic Syndrome X/ complications/epidemiology</keyword><keyword>Obesity/blood/classification/ complications</keyword><keyword>Prevalence</keyword><keyword>Proteins/analysis</keyword><keyword>Risk Factors</keyword><keyword>Severity of Illness Index</keyword></keywords><dates><year>2004</year><pub-dates><date>Jun 3</date></pub-dates></dates><isbn>1533-4406 (Electronic)&#xD;0028-4793 (Linking)</isbn><accession-num>15175438</accession-num><urls></urls><electronic-resource-num>10.1056/NEJMoa031049</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite><Cite><Author>Willemse</Author><Year>2013</Year><RecNum>1483</RecNum><record><rec-number>1483</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1483</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Willemse, P. M.</author><author>Burggraaf, J.</author><author>Hamdy, N. A.</author><author>Weijl, N. I.</author><author>Vossen, C. Y.</author><author>van Wulften, L.</author><author>van Steijn-van Tol, A. Q.</author><author>Rosendaal, F. R.</author><author>Osanto, S.</author></authors></contributors><auth-address>Department of Clinical Oncology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.</auth-address><titles><title>Prevalence of the metabolic syndrome and cardiovascular disease risk in chemotherapy-treated testicular germ cell tumour survivors</title><secondary-title>Br J Cancer</secondary-title><alt-title>British journal of cancer</alt-title></titles><periodical><full-title>British Journal of Cancer</full-title><abbr-1>Br. J. Cancer</abbr-1><abbr-2>Br J Cancer</abbr-2></periodical><alt-periodical><full-title>British Journal of Cancer</full-title><abbr-1>Br. J. Cancer</abbr-1><abbr-2>Br J Cancer</abbr-2></alt-periodical><pages>60-7</pages><volume>109</volume><number>1</number><edition>2013/05/11</edition><keywords><keyword>Adult</keyword><keyword>Antineoplastic Agents/therapeutic use</keyword><keyword>Carboplatin/therapeutic use</keyword><keyword>Cardiovascular Diseases/complications/ epidemiology/mortality</keyword><keyword>Cross-Sectional Studies</keyword><keyword>Drug Therapy, Combination</keyword><keyword>Humans</keyword><keyword>Hypogonadism/complications/ epidemiology</keyword><keyword>Male</keyword><keyword>Metabolic Syndrome X/complications/ epidemiology</keyword><keyword>Middle Aged</keyword><keyword>Neoplasms, Germ Cell and Embryonal/complications/ drug therapy/ epidemiology</keyword><keyword>Prevalence</keyword><keyword>Risk Factors</keyword><keyword>Survivors</keyword><keyword>Testicular Neoplasms/complications/ drug therapy/ epidemiology</keyword><keyword>Testosterone/blood</keyword></keywords><dates><year>2013</year><pub-dates><date>Jul 9</date></pub-dates></dates><isbn>1532-1827 (Electronic)&#xD;0007-0920 (Linking)</isbn><accession-num>23660945</accession-num><urls></urls><custom2>PMC3708554</custom2><electronic-resource-num>10.1038/bjc.2013.226</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>sD���y������K�	_ENREF_1zD<EndNote><Cite><Author>Alberti</Author><Year>2009</Year><RecNum>1484</RecNum><DisplayText>[4-6]</DisplayText><record><rec-number>1484</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1484</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Alberti, K. G.</author><author>Eckel, R. H.</author><author>Grundy, S. M.</author><author>Zimmet, P. Z.</author><author>Cleeman, J. I.</author><author>Donato, K. A.</author><author>Fruchart, J. C.</author><author>James, W. P.</author><author>Loria, C. M.</author><author>Smith, S. C., Jr.</author></authors></contributors><titles><title>Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity</title><secondary-title>Circulation</secondary-title><alt-title>Circulation</alt-title></titles><periodical><full-title>Circulation</full-title><abbr-1>Circulation</abbr-1><abbr-2>Circulation</abbr-2></periodical><alt-periodical><full-title>Circulation</full-title><abbr-1>Circulation</abbr-1><abbr-2>Circulation</abbr-2></alt-periodical><pages>1640-5</pages><volume>120</volume><number>16</number><edition>2009/10/07</edition><keywords><keyword>Abdominal Fat</keyword><keyword>Blood Glucose/metabolism</keyword><keyword>Cardiovascular Diseases/etiology</keyword><keyword>Cholesterol, HDL/blood</keyword><keyword>Diabetes Mellitus/etiology</keyword><keyword>Humans</keyword><keyword>Hypertension/complications</keyword><keyword>Insulin Resistance</keyword><keyword>Metabolic Syndrome X/blood/ diagnosis/etiology</keyword><keyword>Obesity/blood/complications/ diagnosis</keyword><keyword>Risk Factors</keyword><keyword>Terminology as Topic</keyword><keyword>Triglycerides/blood</keyword><keyword>Waist Circumference</keyword></keywords><dates><year>2009</year><pub-dates><date>Oct 20</date></pub-dates></dates><isbn>1524-4539 (Electronic)&#xD;0009-7322 (Linking)</isbn><accession-num>19805654</accession-num><urls></urls><electronic-resource-num>10.1161/circulationaha.109.192644</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite><Cite><Author>Green</Author><Year>2008</Year><RecNum>1485</RecNum><record><rec-number>1485</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1485</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Green, D. J.</author><author>O&apos;Driscoll, G.</author><author>Joyner, M. J.</author><author>Cable, N. T.</author></authors></contributors><auth-address>Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Henry Cotton Campus, 15-21 Webster St., Liverpool L3 2ET, UK. d.j.green@ljmu.ac.uk</auth-address><titles><title>Exercise and cardiovascular risk reduction: time to update the rationale for exercise?</title><secondary-title>J Appl Physiol (1985)</secondary-title><alt-title>Journal of applied physiology (Bethesda, Md. : 1985)</alt-title></titles><periodical><full-title>J Appl Physiol (1985)</full-title><abbr-1>Journal of applied physiology (Bethesda, Md. : 1985)</abbr-1></periodical><alt-periodical><full-title>J Appl Physiol (1985)</full-title><abbr-1>Journal of applied physiology (Bethesda, Md. : 1985)</abbr-1></alt-periodical><pages>766-8</pages><volume>105</volume><number>2</number><edition>2008/01/05</edition><keywords><keyword>Blood Vessels/physiology</keyword><keyword>Cardiovascular Diseases/ epidemiology/ prevention &amp; control</keyword><keyword>Exercise/ physiology</keyword><keyword>Heart Rate/physiology</keyword><keyword>Humans</keyword><keyword>Physical Fitness</keyword><keyword>Risk Reduction Behavior</keyword></keywords><dates><year>2008</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>8750-7587 (Print)&#xD;0161-7567 (Linking)</isbn><accession-num>18174390</accession-num><urls></urls><electronic-resource-num>10.1152/japplphysiol.01028.2007</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite><Cite><Author>Sabo</Author><Year>2012</Year><RecNum>1486</RecNum><record><rec-number>1486</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1486</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sabo, R. T.</author><author>Lu, Z.</author><author>Deng, X.</author><author>Ren, C.</author><author>Daniels, S.</author><author>Arslanian, S.</author><author>Sun, S. S.</author></authors></contributors><auth-address>Department of Biostatistics, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA. rsabo@vcu.edu</auth-address><titles><title>Parental and offspring associations of the metabolic syndrome in the Fels Longitudinal Study</title><secondary-title>Am J Clin Nutr</secondary-title><alt-title>The American journal of clinical nutrition</alt-title></titles><periodical><full-title>American Journal of Clinical Nutrition</full-title><abbr-1>Am. J. Clin. Nutr.</abbr-1><abbr-2>Am J Clin Nutr</abbr-2></periodical><pages>461-6</pages><volume>96</volume><number>3</number><edition>2012/07/20</edition><keywords><keyword>Blood Glucose/analysis</keyword><keyword>Blood Pressure</keyword><keyword>Cholesterol, HDL/blood</keyword><keyword>Family Health</keyword><keyword>Fathers</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Infant, Newborn</keyword><keyword>Longitudinal Studies</keyword><keyword>Male</keyword><keyword>Metabolic Syndrome X/blood/ epidemiology/ etiology</keyword><keyword>Mothers</keyword><keyword>Prevalence</keyword><keyword>Risk Factors</keyword><keyword>Sex Factors</keyword><keyword>Triglycerides/blood</keyword><keyword>United States/epidemiology</keyword><keyword>Waist Circumference</keyword></keywords><dates><year>2012</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>1938-3207 (Electronic)&#xD;0002-9165 (Linking)</isbn><accession-num>22811445</accession-num><urls></urls><custom2>PMC3417210</custom2><electronic-resource-num>10.3945/ajcn.111.025635</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>sD���y������K�	_ENREF_4�D<EndNote><Cite><Author>Kim</Author><Year>2012</Year><RecNum>1487</RecNum><DisplayText>[7,8]</DisplayText><record><rec-number>1487</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1487</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kim, K.</author><author>Yang, Y. J.</author><author>Kim, K.</author><author>Kim, M. K.</author></authors></contributors><auth-address>Department of Preventive Medicine, Hanyang University, College of Medicine, Seoul, Korea.</auth-address><titles><title>Interactions of single nucleotide polymorphisms with dietary calcium intake on the risk of metabolic syndrome</title><secondary-title>Am J Clin Nutr</secondary-title><alt-title>The American journal of clinical nutrition</alt-title></titles><periodical><full-title>American Journal of Clinical Nutrition</full-title><abbr-1>Am. J. Clin. Nutr.</abbr-1><abbr-2>Am J Clin Nutr</abbr-2></periodical><pages>231-40</pages><volume>95</volume><number>1</number><edition>2011/12/16</edition><keywords><keyword>Alleles</keyword><keyword>Calcium, Dietary/ therapeutic use</keyword><keyword>Diet</keyword><keyword>Female</keyword><keyword>Homozygote</keyword><keyword>Humans</keyword><keyword>Logistic Models</keyword><keyword>Male</keyword><keyword>Metabolic Syndrome X/ genetics/ prevention &amp; control</keyword><keyword>Middle Aged</keyword><keyword>Nutrigenomics</keyword><keyword>Polymorphism, Single Nucleotide/ physiology</keyword><keyword>Republic of Korea</keyword><keyword>Risk Factors</keyword></keywords><dates><year>2012</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>1938-3207 (Electronic)&#xD;0002-9165 (Linking)</isbn><accession-num>22170361</accession-num><urls></urls><electronic-resource-num>10.3945/ajcn.111.022749</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite><Cite><Author>Astell</Author><Year>2013</Year><RecNum>1488</RecNum><record><rec-number>1488</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1488</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Astell, K. J.</author><author>Mathai, M. L.</author><author>McAinch, A. J.</author><author>Stathis, C. G.</author><author>Su, X. Q.</author></authors></contributors><auth-address>Biomedical and Lifestyle Diseases (BioLED) Unit, College of Health and Biomedicine, Victoria University, Melbourne, Victoria 3021, Australia.</auth-address><titles><title>A pilot study investigating the effect of Caralluma fimbriata extract on the risk factors of metabolic syndrome in overweight and obese subjects: a randomised controlled clinical trial</title><secondary-title>Complement Ther Med</secondary-title><alt-title>Complementary therapies in medicine</alt-title></titles><periodical><full-title>Complementary Therapies in Medicine</full-title><abbr-1>Complement. Ther. Med.</abbr-1><abbr-2>Complement Ther Med</abbr-2></periodical><alt-periodical><full-title>Complementary Therapies in Medicine</full-title><abbr-1>Complement. Ther. Med.</abbr-1><abbr-2>Complement Ther Med</abbr-2></alt-periodical><pages>180-9</pages><volume>21</volume><number>3</number><edition>2013/05/07</edition><keywords><keyword>Adult</keyword><keyword>Appetite/ drug effects</keyword><keyword>Appetite Depressants/pharmacology/ therapeutic use</keyword><keyword>Asclepiadaceae</keyword><keyword>Body Mass Index</keyword><keyword>Body Weight/drug effects</keyword><keyword>Diet</keyword><keyword>Female</keyword><keyword>Hemodynamics/drug effects</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Metabolic Syndrome X/blood/etiology/ prevention &amp; control</keyword><keyword>Middle Aged</keyword><keyword>Obesity/blood/ drug therapy</keyword><keyword>Overweight</keyword><keyword>Phytotherapy</keyword><keyword>Pilot Projects</keyword><keyword>Plant Extracts/pharmacology/therapeutic use</keyword><keyword>Risk Factors</keyword><keyword>Triglycerides/blood</keyword><keyword>Waist Circumference/ drug effects</keyword><keyword>Waist-Hip Ratio</keyword></keywords><dates><year>2013</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>1873-6963 (Electronic)&#xD;0965-2299 (Linking)</isbn><accession-num>23642949</accession-num><urls></urls><electronic-resource-num>10.1016/j.ctim.2013.01.004</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>sD���y������K�	_ENREF_7sD���y������K�	_ENREF_8�D<EndNote><Cite><Author>Zong</Author><Year>2012</Year><RecNum>1489</RecNum><DisplayText>[9-11]</DisplayText><record><rec-number>1489</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1489</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Zong, G.</author><author>Ye, X.</author><author>Sun, L.</author><author>Li, H.</author><author>Yu, Z.</author><author>Hu, F. B.</author><author>Sun, Q.</author><author>Lin, X.</author></authors></contributors><auth-address>Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Graduate University of the Chinese Academy of Sciences, Shanghai, China.</auth-address><titles><title>Associations of erythrocyte palmitoleic acid with adipokines, inflammatory markers, and the metabolic syndrome in middle-aged and older Chinese</title><secondary-title>Am J Clin Nutr</secondary-title><alt-title>The American journal of clinical nutrition</alt-title></titles><periodical><full-title>American Journal of Clinical Nutrition</full-title><abbr-1>Am. J. Clin. Nutr.</abbr-1><abbr-2>Am J Clin Nutr</abbr-2></periodical><pages>970-6</pages><volume>96</volume><number>5</number><edition>2012/09/28</edition><keywords><keyword>Adiponectin/blood</keyword><keyword>Age Factors</keyword><keyword>Aged</keyword><keyword>Asian Continental Ancestry Group</keyword><keyword>Blood Glucose/analysis/metabolism</keyword><keyword>Blood Pressure</keyword><keyword>C-Reactive Protein/metabolism</keyword><keyword>Cholesterol/blood</keyword><keyword>Erythrocytes/ metabolism</keyword><keyword>Fatty Acids, Monounsaturated/ analysis</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Inflammation Mediators/ blood</keyword><keyword>Insulin/blood</keyword><keyword>Lipids/blood</keyword><keyword>Logistic Models</keyword><keyword>Male</keyword><keyword>Metabolic Syndrome X/ blood</keyword><keyword>Middle Aged</keyword><keyword>Multivariate Analysis</keyword><keyword>Plasminogen Activator Inhibitor 1/blood</keyword><keyword>Retinol-Binding Proteins, Plasma/metabolism</keyword><keyword>Triglycerides/blood</keyword></keywords><dates><year>2012</year><pub-dates><date>Nov</date></pub-dates></dates><isbn>1938-3207 (Electronic)&#xD;0002-9165 (Linking)</isbn><accession-num>23015321</accession-num><urls></urls><custom2>PMC3471208</custom2><electronic-resource-num>10.3945/ajcn.112.040204</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite><Cite><Author>Chen</Author><Year>2009</Year><RecNum>1490</RecNum><record><rec-number>1490</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1490</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Chen, J.</author><author>Gu, D.</author><author>Huang, J.</author><author>Rao, D. C.</author><author>Jaquish, C. E.</author><author>Hixson, J. E.</author><author>Chen, C. S.</author><author>Chen, J.</author><author>Lu, F.</author><author>Hu, D.</author><author>Rice, T.</author><author>Kelly, T. N.</author><author>Hamm, L. L.</author><author>Whelton, P. K.</author><author>He, J.</author></authors></contributors><auth-address>Department of Medicine and Tulane Hypertension and Renal Center of Excellence, School of Medicine, Tulane University, New Orleans, LA, USA.</auth-address><titles><title>Metabolic syndrome and salt sensitivity of blood pressure in non-diabetic people in China: a dietary intervention study</title><secondary-title>Lancet</secondary-title><alt-title>Lancet</alt-title></titles><periodical><full-title>Lancet</full-title><abbr-1>Lancet</abbr-1><abbr-2>Lancet</abbr-2></periodical><alt-periodical><full-title>Lancet</full-title><abbr-1>Lancet</abbr-1><abbr-2>Lancet</abbr-2></alt-periodical><pages>829-35</pages><volume>373</volume><number>9666</number><edition>2009/02/19</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Blood Pressure/ drug effects</keyword><keyword>China/epidemiology</keyword><keyword>Humans</keyword><keyword>Hypertension/chemically induced/ complications/diet therapy</keyword><keyword>Linear Models</keyword><keyword>Metabolic Syndrome X/diet therapy/epidemiology/ etiology</keyword><keyword>Middle Aged</keyword><keyword>Risk Factors</keyword><keyword>Rural Population</keyword><keyword>Sodium Chloride, Dietary/administration &amp; dosage/ adverse effects/pharmacology</keyword><keyword>Young Adult</keyword></keywords><dates><year>2009</year><pub-dates><date>Mar 7</date></pub-dates></dates><isbn>1474-547X (Electronic)&#xD;0140-6736 (Linking)</isbn><accession-num>19223069</accession-num><urls></urls><custom2>PMC2822441</custom2><custom6>Nihms108867</custom6><electronic-resource-num>10.1016/s0140-6736(09)60144-6</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite><Cite><Author>Gu</Author><Year>2005</Year><RecNum>1491</RecNum><record><rec-number>1491</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1491</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Gu, D.</author><author>Reynolds, K.</author><author>Wu, X.</author><author>Chen, J.</author><author>Duan, X.</author><author>Reynolds, R. F.</author><author>Whelton, P. K.</author><author>He, J.</author></authors></contributors><auth-address>Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. jhe@tulane.edu</auth-address><titles><title>Prevalence of the metabolic syndrome and overweight among adults in China</title><secondary-title>Lancet</secondary-title><alt-title>Lancet</alt-title></titles><periodical><full-title>Lancet</full-title><abbr-1>Lancet</abbr-1><abbr-2>Lancet</abbr-2></periodical><alt-periodical><full-title>Lancet</full-title><abbr-1>Lancet</abbr-1><abbr-2>Lancet</abbr-2></alt-periodical><pages>1398-405</pages><volume>365</volume><number>9468</number><edition>2005/04/20</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>China/epidemiology</keyword><keyword>Cross-Sectional Studies</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Lipids/blood</keyword><keyword>Male</keyword><keyword>Metabolic Syndrome X/ epidemiology</keyword><keyword>Middle Aged</keyword><keyword>Obesity/ epidemiology</keyword><keyword>Prevalence</keyword><keyword>Waist-Hip Ratio</keyword></keywords><dates><year>2005</year><pub-dates><date>Apr 16-22</date></pub-dates></dates><isbn>1474-547X (Electronic)&#xD;0140-6736 (Linking)</isbn><accession-num>15836888</accession-num><urls></urls><electronic-resource-num>10.1016/s0140-6736(05)66375-1</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>sD���y������K�	_ENREF_9uD���y������K�
_ENREF_11�D<EndNote><Cite><Author>Sun</Author><Year>2008</Year><RecNum>1492</RecNum><DisplayText>[12]</DisplayText><record><rec-number>1492</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1492</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sun, F.</author><author>Tao, Q. S.</author><author>Zhan, S. Y.</author></authors></contributors><auth-address>Department of Epidemiology and Bio-statistics, Peking University, Beijing 100083, China.</auth-address><titles><title>[Comparison of five different diagnostic criteria on metabolic syndrome applied during physical check-up programs among population aged 35-74, in Taiwan]</title><secondary-title>Zhonghua Liu Xing Bing Xue Za Zhi</secondary-title><alt-title>Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi</alt-title></titles><periodical><full-title>Zhonghua Liu Xing Bing Xue Za Zhi</full-title><abbr-1>Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi</abbr-1></periodical><alt-periodical><full-title>Zhonghua Liu Xing Bing Xue Za Zhi</full-title><abbr-1>Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi</abbr-1></alt-periodical><pages>925-9</pages><volume>29</volume><number>9</number><edition>2009/01/29</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Blood Glucose/analysis</keyword><keyword>Diabetes Mellitus, Type 2/diagnosis/epidemiology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Metabolic Syndrome X/ diagnosis/epidemiology</keyword><keyword>Middle Aged</keyword><keyword>Obesity/diagnosis/epidemiology</keyword><keyword>Physical Examination/ standards</keyword><keyword>Prevalence</keyword><keyword>Reference Standards</keyword><keyword>Taiwan</keyword></keywords><dates><year>2008</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>0254-6450 (Print)&#xD;0254-6450 (Linking)</isbn><accession-num>19173861</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>chi</language></record></Cite></EndNote>uD���y������K�
_ENREF_12b
D<EndNote><Cite><Author>Willemse</Author><Year>2013</Year><RecNum>1483</RecNum><DisplayText>[3]</DisplayText><record><rec-number>1483</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1483</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Willemse, P. M.</author><author>Burggraaf, J.</author><author>Hamdy, N. A.</author><author>Weijl, N. I.</author><author>Vossen, C. Y.</author><author>van Wulften, L.</author><author>van Steijn-van Tol, A. Q.</author><author>Rosendaal, F. R.</author><author>Osanto, S.</author></authors></contributors><auth-address>Department of Clinical Oncology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.</auth-address><titles><title>Prevalence of the metabolic syndrome and cardiovascular disease risk in chemotherapy-treated testicular germ cell tumour survivors</title><secondary-title>Br J Cancer</secondary-title><alt-title>British journal of cancer</alt-title></titles><periodical><full-title>British Journal of Cancer</full-title><abbr-1>Br. J. Cancer</abbr-1><abbr-2>Br J Cancer</abbr-2></periodical><alt-periodical><full-title>British Journal of Cancer</full-title><abbr-1>Br. J. Cancer</abbr-1><abbr-2>Br J Cancer</abbr-2></alt-periodical><pages>60-7</pages><volume>109</volume><number>1</number><edition>2013/05/11</edition><keywords><keyword>Adult</keyword><keyword>Antineoplastic Agents/therapeutic use</keyword><keyword>Carboplatin/therapeutic use</keyword><keyword>Cardiovascular Diseases/complications/ epidemiology/mortality</keyword><keyword>Cross-Sectional Studies</keyword><keyword>Drug Therapy, Combination</keyword><keyword>Humans</keyword><keyword>Hypogonadism/complications/ epidemiology</keyword><keyword>Male</keyword><keyword>Metabolic Syndrome X/complications/ epidemiology</keyword><keyword>Middle Aged</keyword><keyword>Neoplasms, Germ Cell and Embryonal/complications/ drug therapy/ epidemiology</keyword><keyword>Prevalence</keyword><keyword>Risk Factors</keyword><keyword>Survivors</keyword><keyword>Testicular Neoplasms/complications/ drug therapy/ epidemiology</keyword><keyword>Testosterone/blood</keyword></keywords><dates><year>2013</year><pub-dates><date>Jul 9</date></pub-dates></dates><isbn>1532-1827 (Electronic)&#xD;0007-0920 (Linking)</isbn><accession-num>23660945</accession-num><urls></urls><custom2>PMC3708554</custom2><electronic-resource-num>10.1038/bjc.2013.226</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>sD���y������K�	_ENREF_3�
D<EndNote><Cite><Author>Su</Author><Year>2012</Year><RecNum>1493</RecNum><DisplayText>[13]</DisplayText><record><rec-number>1493</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1493</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Su, H. M.</author><author>Lin, T. H.</author><author>Hsu, P. C.</author><author>Chu, C. Y.</author><author>Lee, W. H.</author><author>Chen, S. C.</author><author>Lee, C. S.</author><author>Voon, W. C.</author><author>Lai, W. T.</author><author>Sheu, S. H.</author></authors></contributors><auth-address>Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Taiwan.</auth-address><titles><title>Impact of systolic time intervals on the relationship between arterial stiffness and left ventricular hypertrophy</title><secondary-title>Atherosclerosis</secondary-title><alt-title>Atherosclerosis</alt-title></titles><periodical><full-title>Atherosclerosis</full-title><abbr-1>Atherosclerosis</abbr-1><abbr-2>Atherosclerosis</abbr-2></periodical><alt-periodical><full-title>Atherosclerosis</full-title><abbr-1>Atherosclerosis</abbr-1><abbr-2>Atherosclerosis</abbr-2></alt-periodical><pages>171-6</pages><volume>223</volume><number>1</number><edition>2012/05/29</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Ankle Brachial Index</keyword><keyword>Blood Flow Velocity</keyword><keyword>Brachial Artery/ physiopathology</keyword><keyword>Echocardiography</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Hypertrophy, Left Ventricular/diagnosis/ physiopathology</keyword><keyword>Linear Models</keyword><keyword>Logistic Models</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Multivariate Analysis</keyword><keyword>Predictive Value of Tests</keyword><keyword>Prognosis</keyword><keyword>Pulsatile Flow</keyword><keyword>Risk Assessment</keyword><keyword>Risk Factors</keyword><keyword>Stroke Volume</keyword><keyword>Systole</keyword><keyword>Taiwan</keyword><keyword>Time Factors</keyword><keyword>Vascular Stiffness</keyword><keyword>Ventricular Dysfunction, Left/diagnosis/ physiopathology</keyword><keyword>Ventricular Function, Left</keyword></keywords><dates><year>2012</year><pub-dates><date>Jul</date></pub-dates></dates><isbn>1879-1484 (Electronic)&#xD;0021-9150 (Linking)</isbn><accession-num>22633473</accession-num><urls></urls><electronic-resource-num>10.1016/j.atherosclerosis.2012.04.022</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>uD���y������K�
_ENREF_13�
D<EndNote><Cite><Author>Zong</Author><Year>2012</Year><RecNum>1489</RecNum><DisplayText>[9]</DisplayText><record><rec-number>1489</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1489</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Zong, G.</author><author>Ye, X.</author><author>Sun, L.</author><author>Li, H.</author><author>Yu, Z.</author><author>Hu, F. B.</author><author>Sun, Q.</author><author>Lin, X.</author></authors></contributors><auth-address>Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Graduate University of the Chinese Academy of Sciences, Shanghai, China.</auth-address><titles><title>Associations of erythrocyte palmitoleic acid with adipokines, inflammatory markers, and the metabolic syndrome in middle-aged and older Chinese</title><secondary-title>Am J Clin Nutr</secondary-title><alt-title>The American journal of clinical nutrition</alt-title></titles><periodical><full-title>American Journal of Clinical Nutrition</full-title><abbr-1>Am. J. Clin. Nutr.</abbr-1><abbr-2>Am J Clin Nutr</abbr-2></periodical><pages>970-6</pages><volume>96</volume><number>5</number><edition>2012/09/28</edition><keywords><keyword>Adiponectin/blood</keyword><keyword>Age Factors</keyword><keyword>Aged</keyword><keyword>Asian Continental Ancestry Group</keyword><keyword>Blood Glucose/analysis/metabolism</keyword><keyword>Blood Pressure</keyword><keyword>C-Reactive Protein/metabolism</keyword><keyword>Cholesterol/blood</keyword><keyword>Erythrocytes/ metabolism</keyword><keyword>Fatty Acids, Monounsaturated/ analysis</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Inflammation Mediators/ blood</keyword><keyword>Insulin/blood</keyword><keyword>Lipids/blood</keyword><keyword>Logistic Models</keyword><keyword>Male</keyword><keyword>Metabolic Syndrome X/ blood</keyword><keyword>Middle Aged</keyword><keyword>Multivariate Analysis</keyword><keyword>Plasminogen Activator Inhibitor 1/blood</keyword><keyword>Retinol-Binding Proteins, Plasma/metabolism</keyword><keyword>Triglycerides/blood</keyword></keywords><dates><year>2012</year><pub-dates><date>Nov</date></pub-dates></dates><isbn>1938-3207 (Electronic)&#xD;0002-9165 (Linking)</isbn><accession-num>23015321</accession-num><urls></urls><custom2>PMC3471208</custom2><electronic-resource-num>10.3945/ajcn.112.040204</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>sD���y������K�	_ENREF_9�D<EndNote><Cite><Author>Kang</Author><Year>2010</Year><RecNum>1494</RecNum><DisplayText>[14,15]</DisplayText><record><rec-number>1494</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1494</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kang, S.</author><author>Fan, H. M.</author><author>Li, J.</author><author>Fan, L. Y.</author><author>Miao, A. Y.</author><author>Bao, Y.</author><author>Wu, L. Z.</author><author>Zhu, Y.</author><author>Zhang, D. F.</author><author>Liu, Z. M.</author></authors></contributors><auth-address>Center of Cardiology, Shanghai East Hospital, Tongji University, Jimo Road 150, Shanghai 200120, China.</auth-address><titles><title>Relationship of arterial stiffness and early mild diastolic heart failure in general middle and aged population</title><secondary-title>Eur Heart J</secondary-title><alt-title>European heart journal</alt-title></titles><periodical><full-title>European Heart Journal</full-title><abbr-1>Eur. Heart J.</abbr-1><abbr-2>Eur Heart J</abbr-2></periodical><alt-periodical><full-title>European Heart Journal</full-title><abbr-1>Eur. Heart J.</abbr-1><abbr-2>Eur Heart J</abbr-2></alt-periodical><pages>2799-807</pages><volume>31</volume><number>22</number><edition>2010/08/28</edition><keywords><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Blood Flow Velocity/physiology</keyword><keyword>Brachial Artery/ physiology</keyword><keyword>Cross-Sectional Studies</keyword><keyword>Early Diagnosis</keyword><keyword>Echocardiography</keyword><keyword>Female</keyword><keyword>Heart Failure, Diastolic/diagnosis/ physiopathology</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Pulsatile Flow/physiology</keyword><keyword>Vascular Stiffness/ physiology</keyword></keywords><dates><year>2010</year><pub-dates><date>Nov</date></pub-dates></dates><isbn>1522-9645 (Electronic)&#xD;0195-668X (Linking)</isbn><accession-num>20797980</accession-num><urls></urls><electronic-resource-num>10.1093/eurheartj/ehq296</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite><Cite><Author>Weng</Author><Year>2013</Year><RecNum>1495</RecNum><record><rec-number>1495</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1495</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Weng, C.</author><author>Yuan, H.</author><author>Yang, K.</author><author>Tang, X.</author><author>Huang, Z.</author><author>Huang, L.</author><author>Chen, W.</author><author>Chen, F.</author><author>Chen, Z.</author><author>Yang, P.</author></authors></contributors><auth-address>Department of Cardiology (CW, HY, KY, XT, ZH, LH, WC), Center of Clinical Pharmacology (HY), and Health Management Center (FC, ZC, PY), the Third Xiangya Hospital, Central South University, Changsha, China.</auth-address><titles><title>Gender-specific association between the metabolic syndrome and arterial stiffness in 8,300 subjects</title><secondary-title>Am J Med Sci</secondary-title><alt-title>The American journal of the medical sciences</alt-title></titles><periodical><full-title>American Journal of the Medical Sciences</full-title><abbr-1>Am. J. Med. Sci.</abbr-1><abbr-2>Am J Med Sci</abbr-2></periodical><pages>289-94</pages><volume>346</volume><number>4</number><edition>2013/03/19</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Ankle Brachial Index</keyword><keyword>Blood Pressure</keyword><keyword>China</keyword><keyword>Cross-Sectional Studies</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Metabolic Syndrome X/epidemiology/ physiopathology</keyword><keyword>Middle Aged</keyword><keyword>Pulse Wave Analysis</keyword><keyword>Sex Factors</keyword><keyword>Statistics, Nonparametric</keyword><keyword>Vascular Stiffness</keyword><keyword>Young Adult</keyword></keywords><dates><year>2013</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>1538-2990 (Electronic)&#xD;0002-9629 (Linking)</isbn><accession-num>23503333</accession-num><urls></urls><electronic-resource-num>10.1097/MAJ.0b013e3182732e97</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>uD���y������K�
_ENREF_14uD���y������K�
_ENREF_15D<EndNote><Cite><Author>Yamashina</Author><Year>2002</Year><RecNum>1496</RecNum><DisplayText>[16-18]</DisplayText><record><rec-number>1496</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1496</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Yamashina, A.</author><author>Tomiyama, H.</author><author>Takeda, K.</author><author>Tsuda, H.</author><author>Arai, T.</author><author>Hirose, K.</author><author>Koji, Y.</author><author>Hori, S.</author><author>Yamamoto, Y.</author></authors></contributors><auth-address>Second Department of Internal Medicine, Tokyo Medical University, Japan. akyam@tokyo-med.ac.jp</auth-address><titles><title>Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement</title><secondary-title>Hypertens Res</secondary-title><alt-title>Hypertension research : official journal of the Japanese Society of Hypertension</alt-title></titles><periodical><full-title>Hypertension Research</full-title><abbr-1>Hypertens. Res.</abbr-1><abbr-2>Hypertens Res</abbr-2></periodical><pages>359-64</pages><volume>25</volume><number>3</number><edition>2002/07/24</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Ankle/ blood supply</keyword><keyword>Arteriosclerosis/diagnosis</keyword><keyword>Brachial Artery/ physiopathology</keyword><keyword>Carotid Arteries/physiopathology</keyword><keyword>Coronary Disease/ physiopathology</keyword><keyword>Female</keyword><keyword>Femoral Artery/physiopathology</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Pulse</keyword><keyword>Reproducibility of Results</keyword></keywords><dates><year>2002</year><pub-dates><date>May</date></pub-dates></dates><isbn>0916-9636 (Print)&#xD;0916-9636 (Linking)</isbn><accession-num>12135313</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite><Cite><Author>Paik</Author><Year>2013</Year><RecNum>1497</RecNum><record><rec-number>1497</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1497</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Paik, J. K.</author><author>Kim, M.</author><author>Kwak, J. H.</author><author>Lee, E. K.</author><author>Lee, S. H.</author><author>Lee, J. H.</author></authors></contributors><auth-address>Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Korea.</auth-address><titles><title>Increased arterial stiffness in subjects with impaired fasting glucose</title><secondary-title>J Diabetes Complications</secondary-title><alt-title>Journal of diabetes and its complications</alt-title></titles><periodical><full-title>Journal of Diabetes and Its Complications</full-title><abbr-1>J. Diabetes Complications</abbr-1><abbr-2>J Diabetes Complications</abbr-2><abbr-3>Journal of Diabetes &amp; Its Complications</abbr-3></periodical><alt-periodical><full-title>Journal of Diabetes and Its Complications</full-title><abbr-1>J. Diabetes Complications</abbr-1><abbr-2>J Diabetes Complications</abbr-2><abbr-3>Journal of Diabetes &amp; Its Complications</abbr-3></alt-periodical><pages>224-8</pages><volume>27</volume><number>3</number><edition>2012/11/28</edition><keywords><keyword>Adult</keyword><keyword>Ankle Brachial Index</keyword><keyword>Arteries/immunology/ physiopathology</keyword><keyword>Biological Markers/blood</keyword><keyword>Blood Glucose/analysis</keyword><keyword>C-Reactive Protein/analysis</keyword><keyword>Cross-Sectional Studies</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Hyperglycemia/blood/immunology/ physiopathology</keyword><keyword>Insulin/blood</keyword><keyword>Insulin Resistance</keyword><keyword>Male</keyword><keyword>Malondialdehyde/blood</keyword><keyword>Middle Aged</keyword><keyword>Oxidative Stress</keyword><keyword>Pulse Wave Analysis</keyword><keyword>Vascular Stiffness</keyword></keywords><dates><year>2013</year><pub-dates><date>May-Jun</date></pub-dates></dates><isbn>1873-460X (Electronic)&#xD;1056-8727 (Linking)</isbn><accession-num>23182995</accession-num><urls></urls><electronic-resource-num>10.1016/j.jdiacomp.2012.10.012</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite><Cite><Author>Munakata</Author><Year>2003</Year><RecNum>1498</RecNum><record><rec-number>1498</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1498</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Munakata, M.</author><author>Ito, N.</author><author>Nunokawa, T.</author><author>Yoshinaga, K.</author></authors></contributors><auth-address>Division of Hypertension and Cardiology, Tohoku Rosai Hospital, 3-21 Dainohara 4, Aobaku, Sendai 981-8563, Japan. munakata@tohokuh.rofuku.go.jp</auth-address><titles><title>Utility of automated brachial ankle pulse wave velocity measurements in hypertensive patients</title><secondary-title>Am J Hypertens</secondary-title><alt-title>American journal of hypertension</alt-title></titles><periodical><full-title>American Journal of Hypertension</full-title><abbr-1>Am. J. Hypertens.</abbr-1><abbr-2>Am J Hypertens</abbr-2></periodical><alt-periodical><full-title>American Journal of Hypertension</full-title><abbr-1>Am. J. Hypertens.</abbr-1><abbr-2>Am J Hypertens</abbr-2></alt-periodical><pages>653-7</pages><volume>16</volume><number>8</number><edition>2003/07/25</edition><keywords><keyword>Aged</keyword><keyword>Ankle/ blood supply</keyword><keyword>Anthropometry</keyword><keyword>Blood Circulation Time</keyword><keyword>Body Height</keyword><keyword>Brachial Artery/ physiology</keyword><keyword>Carotid Arteries/physiology</keyword><keyword>Electrocardiography</keyword><keyword>Female</keyword><keyword>Femoral Artery/physiology</keyword><keyword>Humans</keyword><keyword>Hypertension/ diagnosis/ physiopathology</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Phonocardiography</keyword><keyword>Plethysmography</keyword><keyword>Regional Blood Flow/physiology</keyword><keyword>Reproducibility of Results</keyword></keywords><dates><year>2003</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>0895-7061 (Print)&#xD;0895-7061 (Linking)</isbn><accession-num>12878371</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>uD���y������K�
_ENREF_16BD<EndNote><Cite><Author>Lim</Author><Year>2012</Year><RecNum>1500</RecNum><DisplayText>[19-21]</DisplayText><record><rec-number>1500</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1500</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lim, H.</author><author>Nguyen, T.</author><author>Choue, R.</author><author>Wang, Y.</author></authors></contributors><auth-address>Center for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.</auth-address><titles><title>Sociodemographic disparities in the composition of metabolic syndrome components among adults in South Korea</title><secondary-title>Diabetes Care</secondary-title><alt-title>Diabetes care</alt-title></titles><periodical><full-title>Diabetes Care</full-title><abbr-1>Diabetes Care</abbr-1><abbr-2>Diabetes Care</abbr-2></periodical><alt-periodical><full-title>Diabetes Care</full-title><abbr-1>Diabetes Care</abbr-1><abbr-2>Diabetes Care</abbr-2></alt-periodical><pages>2028-35</pages><volume>35</volume><number>10</number><edition>2012/07/28</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Metabolic Syndrome X/ epidemiology</keyword><keyword>Middle Aged</keyword><keyword>Prevalence</keyword><keyword>Republic of Korea/epidemiology</keyword><keyword>Social Class</keyword></keywords><dates><year>2012</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>1935-5548 (Electronic)&#xD;0149-5992 (Linking)</isbn><accession-num>22837361</accession-num><urls></urls><custom2>PMC3447847</custom2><electronic-resource-num>10.2337/dc11-1841</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite><Cite><Author>Cohen</Author><Year>2012</Year><RecNum>1501</RecNum><record><rec-number>1501</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1501</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cohen, E.</author><author>Krause, I.</author><author>Fraser, A.</author><author>Goldberg, E.</author><author>Garty, M.</author></authors></contributors><auth-address>Recanati Center for Medicine and Research, Petah Tikva, Israel. dreytancohen@gmail.com</auth-address><titles><title>Hyperuricemia and metabolic syndrome: lessons from a large cohort from Israel</title><secondary-title>Isr Med Assoc J</secondary-title><alt-title>The Israel Medical Association journal : IMAJ</alt-title></titles><periodical><full-title>Israel Medical Association Journal</full-title><abbr-1>Isr. Med. Assoc. J.</abbr-1><abbr-2>Isr Med Assoc J</abbr-2></periodical><pages>676-80</pages><volume>14</volume><number>11</number><edition>2012/12/18</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Female</keyword><keyword>Follow-Up Studies</keyword><keyword>Humans</keyword><keyword>Hyperuricemia/blood/complications/ epidemiology</keyword><keyword>Insulin Resistance/ physiology</keyword><keyword>Israel/epidemiology</keyword><keyword>Male</keyword><keyword>Mass Screening</keyword><keyword>Metabolic Syndrome X/blood/ epidemiology/etiology</keyword><keyword>Middle Aged</keyword><keyword>Prevalence</keyword><keyword>Retrospective Studies</keyword><keyword>Risk Factors</keyword><keyword>Uric Acid/ blood</keyword><keyword>Young Adult</keyword></keywords><dates><year>2012</year><pub-dates><date>Nov</date></pub-dates></dates><isbn>1565-1088 (Print)</isbn><accession-num>23240372</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite><Cite><Author>Alberti</Author><Year>2005</Year><RecNum>1502</RecNum><record><rec-number>1502</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1502</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Alberti, K. G.</author><author>Zimmet, P.</author><author>Shaw, J.</author></authors></contributors><auth-address>Department of Endocrinology and Metabolism, St Marys Hospital, London W2 1NY, UK. George.Alberti@newcastle.ac.uk</auth-address><titles><title>The metabolic syndrome--a new worldwide definition</title><secondary-title>Lancet</secondary-title><alt-title>Lancet</alt-title></titles><periodical><full-title>Lancet</full-title><abbr-1>Lancet</abbr-1><abbr-2>Lancet</abbr-2></periodical><alt-periodical><full-title>Lancet</full-title><abbr-1>Lancet</abbr-1><abbr-2>Lancet</abbr-2></alt-periodical><pages>1059-62</pages><volume>366</volume><number>9491</number><edition>2005/09/27</edition><keywords><keyword>Asia, Southeastern/ethnology</keyword><keyword>Cardiovascular Diseases/complications</keyword><keyword>China/ethnology</keyword><keyword>Diabetes Mellitus, Type 2/complications</keyword><keyword>Ethnic Groups</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Japan/ethnology</keyword><keyword>Male</keyword><keyword>Metabolic Syndrome X/classification/complications/ diagnosis/ethnology</keyword><keyword>Risk Factors</keyword></keywords><dates><year>2005</year><pub-dates><date>Sep 24-30</date></pub-dates></dates><isbn>1474-547X (Electronic)&#xD;0140-6736 (Linking)</isbn><accession-num>16182882</accession-num><urls></urls><electronic-resource-num>10.1016/s0140-6736(05)67402-8</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>uD���y������K�
_ENREF_19uD���y������K�
_ENREF_22�D<EndNote><Cite><Author>Li</Author><Year>2007</Year><RecNum>1504</RecNum><DisplayText>[23]</DisplayText><record><rec-number>1504</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1504</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Li, Y.</author><author>Zhao, D.</author><author>Wang, W.</author><author>Wang, W. H.</author><author>Sun, J. Y.</author><author>Qin, L. P.</author><author>Jia, Y. N.</author><author>Wu, Z.</author></authors></contributors><auth-address>Department of Epidemiology, Beijing Anzhen Hospital Affiliated the Capital University of Medical Sciences and Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China.</auth-address><titles><title>[A comparison of three diagnostic criterions for metabolic syndrome applied in a Chinese population aged 35-64 in 11 provinces]</title><secondary-title>Zhonghua Liu Xing Bing Xue Za Zhi</secondary-title><alt-title>Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi</alt-title></titles><periodical><full-title>Zhonghua Liu Xing Bing Xue Za Zhi</full-title><abbr-1>Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi</abbr-1></periodical><alt-periodical><full-title>Zhonghua Liu Xing Bing Xue Za Zhi</full-title><abbr-1>Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi</abbr-1></alt-periodical><pages>83-7</pages><volume>28</volume><number>1</number><edition>2007/06/20</edition><keywords><keyword>Adult</keyword><keyword>Asian Continental Ancestry Group</keyword><keyword>Body Mass Index</keyword><keyword>China/epidemiology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Metabolic Syndrome X/ diagnosis/epidemiology</keyword><keyword>Middle Aged</keyword><keyword>Prevalence</keyword><keyword>Waist Circumference</keyword></keywords><dates><year>2007</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>0254-6450 (Print)&#xD;0254-6450 (Linking)</isbn><accession-num>17575940</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>chi</language></record></Cite></EndNote>uD���y������K�
_ENREF_23�D<EndNote><Cite><Author>Weng</Author><Year>2012</Year><RecNum>1505</RecNum><DisplayText>[24]</DisplayText><record><rec-number>1505</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1505</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Weng, C.</author><author>Yuan, H.</author><author>Tang, X.</author><author>Huang, Z.</author><author>Yang, K.</author><author>Chen, W.</author><author>Yang, P.</author><author>Chen, Z.</author><author>Chen, F.</author></authors></contributors><auth-address>Department of Cardiology, the Third Xiangya Hospital, Central South University, Changsha 410013, China.</auth-address><titles><title>Age- and gender dependent association between components of metabolic syndrome and subclinical arterial stiffness in a Chinese population</title><secondary-title>Int J Med Sci</secondary-title><alt-title>International journal of medical sciences</alt-title></titles><periodical><full-title>International Journal of Medical Sciences</full-title><abbr-1>Int. J. Med. Sci.</abbr-1><abbr-2>Int J Med Sci</abbr-2></periodical><alt-periodical><full-title>International Journal of Medical Sciences</full-title><abbr-1>Int. J. Med. Sci.</abbr-1><abbr-2>Int J Med Sci</abbr-2></alt-periodical><pages>730-7</pages><volume>9</volume><number>8</number><edition>2012/10/24</edition><keywords><keyword>Adult</keyword><keyword>Age Factors</keyword><keyword>Aged</keyword><keyword>Arteries/ physiopathology</keyword><keyword>China</keyword><keyword>Cholesterol, HDL/blood</keyword><keyword>Compliance</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Metabolic Syndrome X/ physiopathology</keyword><keyword>Middle Aged</keyword><keyword>Sex Factors</keyword><keyword>Young Adult</keyword></keywords><dates><year>2012</year></dates><isbn>1449-1907 (Electronic)&#xD;1449-1907 (Linking)</isbn><accession-num>23091411</accession-num><urls></urls><custom2>PMC3477683</custom2><electronic-resource-num>10.7150/ijms.4752</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>uD���y������K�
_ENREF_24�D<EndNote><Cite><Author>Zhao</Author><Year>2011</Year><RecNum>1506</RecNum><DisplayText>[25,26]</DisplayText><record><rec-number>1506</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1506</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Zhao, J.</author><author>Pang, Z. C.</author><author>Zhang, L.</author><author>Gao, W. G.</author><author>Wang, S. J.</author><author>Ning, F.</author><author>Nan, H. R.</author><author>Ren, J.</author><author>Qiao, Q.</author></authors></contributors><auth-address>Department of Public Health, University of Helsinki, Helsinki, Finland.</auth-address><titles><title>Prevalence of metabolic syndrome in rural and urban Chinese population in Qingdao</title><secondary-title>J Endocrinol Invest</secondary-title><alt-title>Journal of endocrinological investigation</alt-title></titles><periodical><full-title>Journal of Endocrinological Investigation</full-title><abbr-1>J. Endocrinol. Invest.</abbr-1><abbr-2>J Endocrinol Invest</abbr-2></periodical><alt-periodical><full-title>Journal of Endocrinological Investigation</full-title><abbr-1>J. Endocrinol. Invest.</abbr-1><abbr-2>J Endocrinol Invest</abbr-2></alt-periodical><pages>444-8</pages><volume>34</volume><number>6</number><edition>2011/01/29</edition><dates><year>2011</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>1720-8386 (Electronic)&#xD;0391-4097 (Linking)</isbn><accession-num>21270510</accession-num><urls></urls><electronic-resource-num>10.3275/7482</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite><Cite><Author>Shao</Author><Year>2010</Year><RecNum>1507</RecNum><record><rec-number>1507</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1507</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Shao, J.</author><author>Yu, L.</author><author>Shen, X.</author><author>Li, D.</author><author>Wang, K.</author></authors></contributors><auth-address>Department of Public Health, Xuzhou Medical College, China. jihongshao@gmail.com</auth-address><titles><title>Waist-to-height ratio, an optimal predictor for obesity and metabolic syndrome in Chinese adults</title><secondary-title>J Nutr Health Aging</secondary-title><alt-title>The journal of nutrition, health &amp; aging</alt-title></titles><periodical><full-title>The Journal of Nutrition, Health &amp; Aging</full-title><abbr-1>J. Nutr. Health Aging</abbr-1><abbr-2>J Nutr Health Aging</abbr-2></periodical><alt-periodical><full-title>The Journal of Nutrition, Health &amp; Aging</full-title><abbr-1>J. Nutr. Health Aging</abbr-1><abbr-2>J Nutr Health Aging</abbr-2></alt-periodical><pages>782-5</pages><volume>14</volume><number>9</number><edition>2010/11/19</edition><keywords><keyword>Adult</keyword><keyword>Age Factors</keyword><keyword>Area Under Curve</keyword><keyword>Asian Continental Ancestry Group</keyword><keyword>Body Height</keyword><keyword>Body Mass Index</keyword><keyword>China/epidemiology</keyword><keyword>Cross-Sectional Studies</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Metabolic Syndrome X/ diagnosis/epidemiology/etiology</keyword><keyword>Middle Aged</keyword><keyword>Obesity/complications/ diagnosis</keyword><keyword>Prevalence</keyword><keyword>ROC Curve</keyword><keyword>Reference Values</keyword><keyword>Risk Factors</keyword><keyword>Sex Factors</keyword><keyword>Waist Circumference</keyword><keyword>Waist-Hip Ratio</keyword></keywords><dates><year>2010</year><pub-dates><date>Nov</date></pub-dates></dates><isbn>1760-4788 (Electronic)&#xD;1279-7707 (Linking)</isbn><accession-num>21085910</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>uD���y������K�
_ENREF_25uD���y������K�
_ENREF_26uD���y������K�
_ENREF_11uD���y������K�
_ENREF_27�	D<EndNote><Cite><Author>Zhang</Author><Year>2013</Year><RecNum>1510</RecNum><DisplayText>[28]</DisplayText><record><rec-number>1510</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1510</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Zhang, Y.</author><author>Chen, J.</author><author>Zhang, K.</author><author>Kong, M.</author><author>Wang, T.</author><author>Chen, R.</author><author>Wang, L.</author><author>Wang, J.</author><author>Huang, H.</author></authors></contributors><auth-address>Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 510120 China.</auth-address><titles><title>Inflammation and oxidative stress are associated with the prevalence of high aankle-brachial index in metabolic syndrome patients without chronic renal failure</title><secondary-title>Int J Med Sci</secondary-title><alt-title>International journal of medical sciences</alt-title></titles><periodical><full-title>International Journal of Medical Sciences</full-title><abbr-1>Int. J. Med. Sci.</abbr-1><abbr-2>Int J Med Sci</abbr-2></periodical><alt-periodical><full-title>International Journal of Medical Sciences</full-title><abbr-1>Int. J. Med. Sci.</abbr-1><abbr-2>Int J Med Sci</abbr-2></alt-periodical><pages>183-90</pages><volume>10</volume><number>2</number><edition>2013/01/19</edition><keywords><keyword>Ankle Brachial Index</keyword><keyword>Body Mass Index</keyword><keyword>C-Reactive Protein/metabolism</keyword><keyword>Cardiovascular Diseases/epidemiology/mortality</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Inflammation/ physiopathology</keyword><keyword>Kidney Failure, Chronic/physiopathology</keyword><keyword>Male</keyword><keyword>Metabolic Syndrome X/ physiopathology</keyword><keyword>Middle Aged</keyword><keyword>Oxidative Stress</keyword><keyword>Peripheral Vascular Diseases/metabolism/physiopathology</keyword><keyword>Risk Factors</keyword></keywords><dates><year>2013</year></dates><isbn>1449-1907 (Electronic)&#xD;1449-1907 (Linking)</isbn><accession-num>23329891</accession-num><urls></urls><custom2>PMC3547217</custom2><electronic-resource-num>10.7150/ijms.5308</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>uD���y������K�
_ENREF_28�D<EndNote><Cite><Author>Zhang</Author><Year>2013</Year><RecNum>1510</RecNum><DisplayText>[28,29]</DisplayText><record><rec-number>1510</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1510</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Zhang, Y.</author><author>Chen, J.</author><author>Zhang, K.</author><author>Kong, M.</author><author>Wang, T.</author><author>Chen, R.</author><author>Wang, L.</author><author>Wang, J.</author><author>Huang, H.</author></authors></contributors><auth-address>Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 510120 China.</auth-address><titles><title>Inflammation and oxidative stress are associated with the prevalence of high aankle-brachial index in metabolic syndrome patients without chronic renal failure</title><secondary-title>Int J Med Sci</secondary-title><alt-title>International journal of medical sciences</alt-title></titles><periodical><full-title>International Journal of Medical Sciences</full-title><abbr-1>Int. J. Med. Sci.</abbr-1><abbr-2>Int J Med Sci</abbr-2></periodical><alt-periodical><full-title>International Journal of Medical Sciences</full-title><abbr-1>Int. J. Med. Sci.</abbr-1><abbr-2>Int J Med Sci</abbr-2></alt-periodical><pages>183-90</pages><volume>10</volume><number>2</number><edition>2013/01/19</edition><keywords><keyword>Ankle Brachial Index</keyword><keyword>Body Mass Index</keyword><keyword>C-Reactive Protein/metabolism</keyword><keyword>Cardiovascular Diseases/epidemiology/mortality</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Inflammation/ physiopathology</keyword><keyword>Kidney Failure, Chronic/physiopathology</keyword><keyword>Male</keyword><keyword>Metabolic Syndrome X/ physiopathology</keyword><keyword>Middle Aged</keyword><keyword>Oxidative Stress</keyword><keyword>Peripheral Vascular Diseases/metabolism/physiopathology</keyword><keyword>Risk Factors</keyword></keywords><dates><year>2013</year></dates><isbn>1449-1907 (Electronic)&#xD;1449-1907 (Linking)</isbn><accession-num>23329891</accession-num><urls></urls><custom2>PMC3547217</custom2><electronic-resource-num>10.7150/ijms.5308</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite><Cite><Author>Vita</Author><Year>2004</Year><RecNum>1511</RecNum><record><rec-number>1511</rec-number><foreign-keys><key app="EN" db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">1511</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Vita, J. A.</author><author>Keaney, J. F., Jr.</author><author>Larson, M. G.</author><author>Keyes, M. J.</author><author>Massaro, J. M.</author><author>Lipinska, I.</author><author>Lehman, B. T.</author><author>Fan, S.</author><author>Osypiuk, E.</author><author>Wilson, P. W.</author><author>Vasan, R. S.</author><author>Mitchell, G. F.</author><author>Benjamin, E. J.</author></authors></contributors><auth-address>Evans Memorial Department of Medicine, Boston University School of Medicine, Boston, Mass, USA. jvita@bu.edu</auth-address><titles><title>Brachial artery vasodilator function and systemic inflammation in the Framingham Offspring Study</title><secondary-title>Circulation</secondary-title><alt-title>Circulation</alt-title></titles><periodical><full-title>Circulation</full-title><abbr-1>Circulation</abbr-1><abbr-2>Circulation</abbr-2></periodical><alt-periodical><full-title>Circulation</full-title><abbr-1>Circulation</abbr-1><abbr-2>Circulation</abbr-2></alt-periodical><pages>3604-9</pages><volume>110</volume><number>23</number><edition>2004/12/01</edition><keywords><keyword>Biological Markers/blood</keyword><keyword>Brachial Artery/metabolism/ physiopathology</keyword><keyword>C-Reactive Protein/analysis</keyword><keyword>Chemokine CCL2/blood</keyword><keyword>Clinical Trials as Topic</keyword><keyword>Endothelium, Vascular/metabolism/physiopathology</keyword><keyword>Female</keyword><keyword>Forearm/blood supply</keyword><keyword>Humans</keyword><keyword>Hyperemia/metabolism</keyword><keyword>Inflammation/metabolism/ physiopathology</keyword><keyword>Intercellular Adhesion Molecule-1/blood</keyword><keyword>Interleukin-6/blood</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Vasodilation</keyword></keywords><dates><year>2004</year><pub-dates><date>Dec 7</date></pub-dates></dates><isbn>1524-4539 (Electronic)&#xD;0009-7322 (Linking)</isbn><accession-num>15569842</accession-num><urls></urls><electronic-resource-num>10.1161/01.cir.0000148821.97162.5e</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>uD���y������K�
_ENREF_28uD���y������K�
_ENREF_29b���������666666666vvvvvvvvv666666>666666666666666666666666666�6666666666�66666666666hH66666666666666666666666666666666666666666666666666666666666666666�62���� 0@P`p������2(�� 0@P`p������ 0@P`p������ 0@P`p������ 0@P`p������ 0@P`p������ 0@P`p��8X�V~PJ_HmH	@nH	@sH	@tH	@N`�NNormal$1$a$CJKH_HmH	nHsH	tHDA �DDefault Paragraph FontVi�V
0Table Normal :V�4�4�
la�(k �(
0No List@ �@Footera$$G$
�9r CJ��Headercd�a$$G$@&	$dN��%dO��&dP��'dQ��
�9r CJOJQJh�o�hT�Default1$7$8$H$1B*CJOJQJ^J_HaJmH	nHphsH	tH:U �!:T�	Hyperlink>*B*`Jph�PK!����[Content_Types].xml���j�0E����ж�r�(��΢Iw},��-j��4	��w�P�-t#bΙ{U�����T�U^h�d}㨫��)��*1P�'��	�^��W��0)��T�9<�l�#��$yi}��;�~@��(��H����u�*Dנz��/0�ǰ��$��X��3aZ����,�D0j~�3߶�b��~i>���3�\`�?�/�[���G��\�!�-�Rk.�s�Ի�..���a濭?��PK!�֧�6_rels/.rels���j�0���}Q��%v/��C/�}�(h"���O�
����=������ ����C?�h�v=��Ʌ��%[xp��{۵_�Pѣ<�1�H�0���O�R�Bd���JE�4b$��q_����6L�R�7`������0̞O��,�En7�Li�b��/�S���e��е�����PK!ky���theme/theme/themeManager.xml�M
� @�}�w��7c�(Eb�ˮ��C�AǠҟ����7��՛K
Y,�
�e�.���|,���H�,l����xɴ��I�sQ}#Ր���� ֵ+�!�,�^�$j=�GW��)�E�+&
8���PK!����Ptheme/theme/theme1.xml�YOo�6��w toc'vu�ر�-M�n�i���P�@�I}��úa��m�a[�إ�4�:lЯ�GR��X^�6؊�>$�������!)O�^�r�C$�y@�����/�yH*��񄴽)�޵��߻��UDb�`}"�qۋ�Jח���X^�)I`n�E���p)���li�V[]�1M<������O�P��6r�=���z�gb�Ig��u��S�eb��O������R�D۫����qu	�g��Z����o~ٺlAp�lx�pT0���+[}`j���zA��V�2�F���i�@�q�v�֬5\|��ʜ̭N��le�X�ds���jcs���7���f����
��W��+�Ն�7����`���g�Ș��J���j|��h(�K��D-����
dX��iJ�؇(��x$(��:��;�˹!�I_�T��S1�����?E��?�����?ZBΪm���U/������?�~����xY���'���y5�g&΋/����ɋ�>���G�M�Ge���D�����3Vq%'#q�����$�8��K�����)f�w9:ĵ��
x}r�x����w���r�:\TZaG�*�y8I�j�bR��c|XŻ�ǿ�I
u3KG�nD1�NIB�s���
��R��u���K>V�.EL+M2�#'�f��i~�V��vl�{u8��z��H�
�*���:�(W�☕
~��J�T�e\O*�tHG��HY��}KN�P�*ݾ˦���TѼ�9/#��A7�qZ��$*c?���qU��n��w�N��%��O��i�4=3ڗP��
����1�P�m\\9���������Mؓ�2a�D�]�;Yt�\��[x����]�}Wr��|�]��g-���
eW�
�)6-r��CS�j��
i�d	�DЇA�ΜIqbJ#x�꺃6k���#��A�Sh��&ʌt(Q�%��p%m��&]�caSl=�X�����\P�1�Mh�9�M��V�dDA��aV�B��[݈fJ�íP|8�քA�V^��f
�H��n���-��"�d>�z��n��NJ�	�ة�>�b���&����2��v����Kyϼ��D:����,AGm��\nz��i�Ù��.uχYC�6�OMf��3o�r��$��5�����NH�T[XF64�T,ќ���M0�E)`#�5�XY�`�פ;��%�1�U�٥m;���R>QD����D�cp�U�'��&LE�/p���m���%]�����8fi��r�S4�d7y\�`�J�n���ί�I�R��3U�~7+���׸#��m�q�BiD���������i*�L6�9�m�Y&���i���HE��=(K&�N!V�.K�e�LD�ĕ�{D	����vEꦚde��NƟ��e�(�MN9ߜR�6����&3(��a���/D��U�z�<�{ˊ�Y��ȳ����V���)�9�Z[��4^n��5���!J��?��Q�3�eBo�C����M����m<�.�vp�����IY�f���Z�Y_p�[�=al-�Y�}Nc͙���ŋ4vfa��vl����'S��A�8�|�*u�{��-�ߟ0%M0�7%����<���ҍ���PK!
ѐ��'theme/theme/_rels/themeManager.xml.rels��M
�0���wooӺ�&݈Э���5
6?$Q��
�,.�a��i����c2�1h�:�q��m��@RN��;d�`��o7�g�K(M&$R(.1�r'J��ЊT���8��V�"��AȻ�H�u}��|�$�b{��P����8�g/]�QAsم(����#��L�[������PK-!����[Content_Types].xmlPK-!�֧�6+_rels/.relsPK-!ky���theme/theme/themeManager.xmlPK-!����P�theme/theme/theme1.xmlPK-!
ѐ��'�	theme/theme/_rels/themeManager.xml.relsPK]�
<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<a:clrMap xmlns:a="http://schemas.openxmlformats.org/drawingml/2006/main" bg1="lt1" tx1="dk1" bg2="lt2" tx2="dk2" accent1="accent1" accent2="accent2" accent3="accent3" accent4="accent4" accent5="accent5" accent6="accent6" hlink="hlink" folHlink="folHlink"/>�v������	�gu�{/��J M!�$�&�'�-y7�=}K�O~ac!jĵ@BCDEFGHIJKLMNOPRSTUVW[	.�e�xĵAQXY>	N	d	e	g	�	�	�	P
`
v
w
y
�
�
�
�����
DFH�����'
,
.
f
NP�������������
EGI�MPR�������������9<>�����  ! �"�"�"�"�"�"##^8I@K@}@�@�@�@�@�@�@�@�@AA\AlA�A�A�A�A�A�AhDxD�D�D�D�D�D�D�D�D�DvE^M`M�M�M�M?OLVNVV�V�V�V�V�V�V�V1W4W6W�W�W�W�W�WXXXFXIXKX
_ _�v�vQQ�Dt�Xt��̕�QQ�Dt�Xt��̕�QQ�Dt�Xt���Xt��̕�QQ�Dt�Xt��̕�Qt�Xt��̕�QQ�Dt�Xt��̕�QQ�Dt�Xt��̕�QQ�Dt�Xt��̕�QQ�Dt�Xt��̕�QQ�Dt�Xt���Xt��̕�QQ�Dt�Xt��̕�QQ�Dt�Xt��̕�Qt�Xt��̕�QQ�Dt�Xt��̕�QQ�Dt�Xt��̕�QQ�Dt�Xt���Xt��̕�Qt�Xt��̕�Qt�Xt��̕�QQ�Dt�Xt��̕�QQ�Dt�Xt���Xt��̕�Qt����^�S�����������s���>@�����������0�(	�
��<
�C��  �?���2	OLE_LINK1	OLE_LINK2
OLE_LINK27
OLE_LINK28
OLE_LINK31
OLE_LINK32
OLE_LINK20
OLE_LINK21
OLE_LINK22
OLE_LINK23
OLE_LINK24
OLE_LINK16
OLE_LINK17
OLE_LINK25
OLE_LINK26
OLE_LINK10
OLE_LINK11
OLE_LINK34
OLE_LINK35
OLE_LINK38
OLE_LINK39_ENREF_1_ENREF_2_ENREF_3_ENREF_4_ENREF_5_ENREF_6_ENREF_7_ENREF_8_ENREF_9	_ENREF_10	_ENREF_11	_ENREF_12	_ENREF_13	_ENREF_14	_ENREF_15	_ENREF_16	_ENREF_17	_ENREF_18	_ENREF_19	_ENREF_20	_ENREF_21	_ENREF_22	_ENREF_23	_ENREF_24	_ENREF_25	_ENREF_26	_ENREF_27	_ENREF_28	_ENREF_29h*h*w3w377�A�A�A�B�B�C�C�M�M�V�V�Y�Y�\�\!_>`�`�a�c2d�d�e�f�g\h�h�i�jsk.lm�m]no�o/p�p�q�r`st�t�u�v	

 !"#$%&'()*+,-./01n*n*�4�4^7^7�B�B�B�C�C�M�M�V�V�W�W�\�\[][]=`�`�a�c1d�d�e�f�g[h�h�i�jrk-lm�m\no�o.p�p�q�r_st�t�u�v�v��
ء��k3١��j3ڡ�lk3ۡ�,k3ܡ��j3ݡ�lj3ޡ�le3ߡ��d3࡟,e3ᡟ�d3����i� �!#)x.w2�v	����k� �!*).~2�v	<
*�urn:schemas-microsoft-com:office:smarttags�chmetcnv���7�0�1�1350�1358.5�2012�25�85�C�cm�False�HasSpace�in�kg�mm�Negative
�NumberType�SourceValue�TCSC�True�UnitName
	

	

	

	
	
	
	

	


	
	

	

	
,1RXx~�����������������x|!����/4ae����Z^����$X\vz�����	�	os��L
P
;?����_c����$+����������EJkp5;Xe��B G p y � � � � � � s!t!x!|!�!�!�!�!�!�!�!�!	"
""" """C"O"c'g's'x'9(=(.".P.T.�.�.+/0/J/N/�/�/0!0�0�0�0�0z1~1(2-2K2P2d2i2�3�3�3�3+505Z5^5�5�50646�7�788OASA�B�B%E)EkEmE�M�M�N�N�N�NOO�V�V�X�X�X�XY#Y�Y�Y&Z,Z�\�\�\�\�]�]�]�]L^T^U^X^]^b^�^�^-_4_�v9C]f?Bx��"�"$_[_�v33333
1C��N	e	`
w
��������������$ �"�"z,-�@�@lA�AxD�D�V�V�W�W1_1_�v�v�v
1CRR^^ijlluvww����YYZ[��N	e	`
w
��������������"�":+;+y,y,z,z,�0�0�1�1e3e3�@�@lA�A�A�AxD�D�D�D�D�D`M�MNV�V�V�V�V5W�W�W�WXXJX�]�]1_1_�v�v�v�v�vlnD.CVlnD����Z
Oyf
�7�&
04�H�F�f"&u� 5�L �4 �!A!C!|%�v(�o)�z/�90�B0aa0�N5<97�E7O7�]:(;�?*c@�E�@HoI'^SBFT;uUVmfV�
Z�-Z[�Db�d>&e,-e\Le�
gkcj�Ik�Yk�dn�q�r^u�dx�y�+{�{|,�:j�
6�h�"G��d��o�)1�,E��i�VO�!^�x��9��H��k�S,��9������r��S�
.�N��;����`��X/�K�bO�s(�T;�(��7�q"�IN�,,�7?�T�
0����8���(�y4�ie��m����t��t�$�G<��d��R�?W�(��������q��2�:K�$T��@�cu�\���G�{e�A ��c��!��v�v��EN.InstantFormatu-	EN.Layout��2EN.Libraries
�<ENInstantFormat><Enabled>1</Enabled><ScanUnformatted>1</ScanUnformatted><ScanChanges>1</ScanChanges><Suspended>0</Suspended></ENInstantFormat>�<ENLayout><Style>PLoS</Style><LeftDelim>{</LeftDelim><RightDelim>}</RightDelim><FontName>Times New Roman</FontName><FontSize>10</FontSize><ReflistTitle></ReflistTitle><StartingRefnum>1</StartingRefnum><FirstLineIndent>0</FirstLineIndent><HangingIndent>720</HangingIndent><LineSpacing>0</LineSpacing><SpaceAfter>0</SpaceAfter><HyperlinksEnabled>1</HyperlinksEnabled><HyperlinksVisible>0</HyperlinksVisible></ENLayout>h<Libraries><item db-id="50wxdpzd9vd5r7e9t5b595djrfpttrxw9avp">Sample_Library_X6<record-ids><item>1481</item><item>1482</item><item>1483</item><item>1484</item><item>1485</item><item>1486</item><item>1487</item><item>1488</item><item>1489</item><item>1490</item><item>1491</item><item>1492</item><item>1493</item><item>1494</item><item>1495</item><item>1496</item><item>1497</item><item>1498</item><item>1500</item><item>1501</item><item>1502</item><item>1503</item><item>1504</item><item>1505</item><item>1506</item><item>1507</item><item>1509</item><item>1510</item><item>1511</item></record-ids></item></Libraries>�@�1_1_�1_1_4 #�t�v`@`(`\@`h@��Unknown������������G��*�Ax�	�Times New Roman5��Symbol3.��*�Cx�	�ArialG5��
	���j�MS Mincho-�3� fg;���(SimSun�[SOA���Book AntiquaA���$B�Cambria Math A���QhZ"G�H,G'���d<���d<�!Z&!),.:;?]}����    & 6"0000	00
00000���	������=�@�\�]�^��([{�  0
000000��;�[�������2hvhv2�q��	�?����������������������'*2!xx���xvzuAbhishek����Oh��+'��0`�������	��
(
4@HPX�研究生Normal.dotmAbhishek39Microsoft Office Word@�?�6@,��&�@��(���d����՜.��+,��D��՜.��+,��@�hp��������
���同济大学医学院�<hvTitleH([c/_PID_HLINKSKSOProductBuildVer�A��C��
_ENREF_29C��
_ENREF_28C��
_ENREF_28C��
_ENREF_27@��
_ENREF_11C��
_ENREF_26C~�
_ENREF_25Cv�
_ENREF_24Cn�
_ENREF_23Cf�
_ENREF_22@`�
_ENREF_19@X�
_ENREF_16@P�
_ENREF_15@M�
_ENREF_14HE�	_ENREF_9@=�
_ENREF_13B5�	_ENREF_3@-�
_ENREF_12@%�
_ENREF_11H�	_ENREF_9I�	_ENREF_8F�	_ENREF_7E�	_ENREF_4@�	_ENREF_12052-9.1.0.3914	

 !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\����^_`abcdefghijklmnopqrstuvwxyz{|}~���������������������������������������������������������������������������������������������������������������������������������������

��������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������Root Entry��������	�F��1)��Data
������������]�1Table�����:?WordDocument����2�SummaryInformation(������������	DocumentSummaryInformation8��������CompObj������������y������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������
����	�F'Microsoft Office Word 97-2003 Document
MSWordDocWord.Document.8�9�q

Youez - 2016 - github.com/yon3zu
LinuXploit