����JFIFXX�����    $.' ",#(7),01444'9=82<.342  2!!22222222222222222222222222222222222222222222222222����"��4�� ���,�PG"Z_�4�˷����kjز�Z�,F+��_z�,�© �����zh6�٨�ic�fu���#ډb���_�N�?��wQ���5-�~�I���8����TK<5o�Iv-�����k�_U_�����~b�M��d����Ӝ�U�Hh��?]��E�w��Q���k�{��_}qFW7HTՑ��Y��F�?_�'ϔ��_�Ջt��=||I ��6�έ"�����D���/[�k�9���Y�8ds|\���Ҿp6�Ҵ���]��.����6�z<�v��@]�i%��$j��~�g��J>��no����pM[me�i$[����s�o�ᘨ�˸ nɜG-�ĨU�ycP�3.DB�li�;��hj���x7Z^�N�h������N3u{�:j�x�힞��#M&��jL P@_���� P��&��o8������9�����@Sz6�t7#O�ߋ �s}Yf�T���lmr����Z)'N��k�۞p����w\�Tȯ?�8`�O��i{wﭹW�[�r�� ��Q4F�׊���3m&L�=��h3����z~��#�\�l :�F,j@�� ʱ�wQT����8�"kJO���6�֚l����}���R�>ډK���]��y����&����p�}b��;N�1�m�r$�|��7�>e�@B�TM*-iH��g�D�)� E�m�|�ؘbҗ�a��Ҿ����t4���o���G��*oCN�rP���Q��@z,|?W[0�����:�n,jWiE��W��$~/�hp\��?��{(�0���+�Y8rΟ�+����>S-S����VN;�}�s?.����� w�9��˟<���Mq4�Wv'��{)0�1mB��V����W[�����8�/<� �%���wT^�5���b��)iM� pg�N�&ݝ��VO~�q���u���9� ����!��J27����$O-���! �:�%H��� ـ����y�ΠM=t{!S�� oK8������t<����è:a������[�����ա�H���~��w��Qz`�po�^ ����Q��n� �,uu�C�$ ^���,������8�#��:�6��e�|~���!�3�3.�\0��q��o�4`.|� ����y�Q�`~;�d�ׯ,��O�Zw�������`73�v�܋�<���Ȏ�� ـ4k��5�K�a�u�=9Yd��$>x�A�&�� j0� ���vF��� Y�|�y��� ~�6�@c��1vOp�Ig����4��l�OD���L����� R���c���j�_�uX6��3?nk��Wy�f;^*B� ��@�~a�`��Eu������+���6�L��.ü>��}y���}_�O�6�͐�:�YrG�X��kG�����l^w���~㒶sy��Iu�!� W ��X��N�7BV��O��!X�2����wvG�R�f�T#�����t�/?���%8�^�W�aT��G�cL�M���I��(J����1~�8�?aT ���]����AS�E��(��*E}� 2��#I/�׍qz��^t�̔���b�Yz4x���t�){ OH��+(E��A&�N�������XT��o��"�XC��'���)}�J�z�p� ��~5�}�^����+�6����w��c��Q�|Lp�d�H��}�(�.|����k��c4^�"�����Z?ȕ ��a<�L�!039C� �Eu�C�F�Ew�ç ;�n?�*o���B�8�bʝ���'#Rqf���M}7����]����s2tcS{�\icTx;�\��7K���P���ʇ Z O-��~��c>"��?�������P��E��O�8��@�8��G��Q�g�a�Վ���󁶠�䧘��_%#r�>�1�z�a��eb��qcPѵ��n���#L��� =��׀t� L�7�`��V���A{�C:�g���e@�w1 Xp3�c3�ġ����p��M"'-�@n4���fG��B3�DJ�8[Jo�ߐ���gK)ƛ��$���� ���8�3�����+���� �����6�ʻ���� ���S�kI�*KZlT _`���?��K����QK�d����B`�s}�>���`��*�>��,*@J�d�oF*����弝��O}�k��s��]��y�ߘ��c1G�V���<=�7��7����6�q�PT��tXԀ�!9*4�4Tހ3XΛex�46���Y��D ����� �BdemDa����\�_l,��G�/���֌7���Y�](�xTt^%�GE�����4�}bT���ڹ�����;Y)���B�Q��u��>J/J �⮶.�XԄ��j�ݳ�+E��d ��r�5�_D�1 ��o�� �B�x�΢�#���<��W�����8���R6�@g�M�.��� dr�D��>(otU��@x=��~v���2� ӣ�d�oBd��3�eO�6�㣷�����ݜ6��6Y��Qz`��S��{���\P�~z m5{J/L��1������<�e�ͅPu�b�]�ϔ���'������f�b� Zpw��c`"��i���BD@:)ִ�:�]��hv�E�w���T�l��P���"Ju�}��وV J��G6��. J/�Qgl߭�e�����@�z�Zev2u�)]կ�����7x���s�M�-<ɯ�c��r�v�����@��$�ޮ}lk���a���'����>x��O\�ZFu>�����ck#��&:��`�$�ai�>2Δ����l���oF[h��lE�ܺ�Πk:)���`�� $[6�����9�����kOw�\|���8}������ބ:��񶐕��I�A1/�=�2[�,�!��.}gN#�u����b��� ~��݊��}34q����d�E��Lc��$��"�[q�U�硬g^��%B �z���r�pJ�ru%v\h1Y�ne`ǥ:g���pQM~�^�Xi� ��`S�:V29.�P���V�?B�k�� AEvw%�_�9C�Q����wKekPؠ�\�;Io d�{ ߞo�c1eP����\� `����E=���@K<�Y���eڼ�J���w����{av�F�'�M�@/J��+9p���|]�����Iw &`��8���&M�hg��[�{��Xj��%��Ӓ�$��(����ʹN���<>�I���RY���K2�NPlL�ɀ)��&e����B+ь����( � �JTx���_?EZ� }@ 6�U���뙢ط�z��dWI�n` D����噥�[��uV��"�G&Ú����2g�}&m��?ċ�"����Om#��������� ��{�ON��"S�X��Ne��ysQ���@Fn��Vg���dX�~nj�]J�<�K]:��FW��b�������62�=��5f����JKw��bf�X�55��~J �%^����:�-�QIE��P��v�nZum� z � ~ə ���� ���ة����;�f��\v���g�8�1��f24;�V���ǔ�)����9���1\��c��v�/'Ƞ�w�������$�4�R-��t���� e�6�/�ġ �̕Ecy�J���u�B���<�W�ַ~�w[B1L۲�-JS΂�{���΃������A��20�c#��@ 0!1@AP"#2Q`$3V�%45a6�FRUq��� ����^7ׅ,$n�������+��F�`��2X'��0vM��p�L=������5��8������u�p~���.�`r�����\���O��,ư�0oS ��_�M�����l���4�kv\JSd���x���SW�<��Ae�IX����������$I���w�:S���y���›R��9�Q[���,�5�;�@]�%���u�@ *ro�lbI �� ��+���%m:�͇ZV�����u�̉����θau<�fc�.����{�4Ա� �Q����*�Sm��8\ujqs]{kN���)qO�y�_*dJ�b�7���yQqI&9�ԌK!�M}�R�;������S�T���1���i[U�ɵz�]��U)V�S6���3$K{�ߊ<�(� E]Զ[ǼENg�����'�\?#)Dkf��J���o��v���'�%ƞ�&K�u�!��b�35LX�Ϸ��63$K�a�;�9>,R��W��3�3� d�JeTYE.Mϧ��-�o�j3+y��y^�c�������VO�9NV\nd�1 ��!͕_)a�v;����թ�M�lWR1��)El��P;��yوÏ�u 3�k�5Pr6<�⒲l�!˞*��u־�n�!�l:����UNW ��%��Chx8vL'��X�@��*��)���̮��ˍ��� ���D-M�+J�U�kvK����+�x8��cY������?�Ԡ��~3mo��|�u@[XeY�C�\Kp�x8�oC�C�&����N�~3-H���� ��MX�s�u<`���~"WL��$8ξ��3���a�)|:@�m�\���^�`�@ҷ)�5p+��6���p�%i)P M���ngc�����#0Aruz���RL+xSS?���ʮ}()#�t��mˇ!��0}}y����<�e� �-ή�Ԩ��X������ MF���ԙ~l L.3���}�V뽺�v�����멬��Nl�)�2����^�Iq��a��M��qG��T�����c3#������3U�Ǎ���}��לS�|qa��ڃ�+���-��2�f����/��bz��ڐ�� �ݼ[2�ç����k�X�2�* �Z�d���J�G����M*9W���s{��w���T��x��y,�in�O�v��]���n����P�$�JB@=4�OTI�n��e�22a\����q�d���%�$��(���:���: /*�K[PR�fr\nڙdN���F�n�$�4�[�� U�zƶ����� �mʋ���,�ao�u 3�z� �x��Kn����\[��VFmbE;�_U��&V�Gg�]L�۪&#n%�$ɯ�dG���D�TI=�%+AB�Ru#��b4�1�»x�cs�YzڙJG��f��Il��d�eF'T� iA��T���uC�$����Y��H?����[!G`}���ͪ� �纤Hv\������j�Ex�K���!���OiƸ�Yj�+u-<���'q����uN�*�r\��+�]���<�wOZ.fp�ێ��,-*)V?j-kÊ#�`�r��dV����(�ݽBk�����G�ƛk�QmUڗe��Z���f}|����8�8��a���i��3'J�����~G_�^���d�8w������ R�`(�~�.��u���l�s+g�bv���W���lGc}��u���afE~1�Ue������Z�0�8�=e�� f@/�jqEKQQ�J��oN��J���W5~M>$6�Lt�;$ʳ{���^��6�{����v6���ķܰg�V�cnn �~z�x�«�,2�u�?cE+Ș�H؎�%�Za�)���X>uW�Tz�Nyo����s���FQƤ��$��*�&�LLXL)�1�" L��eO��ɟ�9=���:t��Z���c��Ž���Y?�ӭV�wv�~,Y��r�ۗ�|�y��GaF�����C�����.�+� ���v1���fήJ�����]�S��T��B��n5sW}y�$��~z�'�c ��8 ��� ,! �p��VN�S��N�N�q��y8z˱�A��4��*��'������2n<�s���^ǧ˭P�Jޮɏ�U�G�L�J�*#��<�V��t7�8����TĜ>��i}K%,���)[��z�21z ?�N�i�n1?T�I�R#��m-�����������������1����lA�`��fT5+��ܐ�c�q՝��ʐ��,���3�f2U�եmab��#ŠdQ�y>\��)�SLY����w#��.���ʑ�f��� ,"+�w�~�N�'�c�O�3F�������N<���)j��&��,-� �љ���֊�_�zS���TǦ����w�>��?�������n��U仆�V���e�����0���$�C�d���rP �m�׈e�Xm�Vu� �L��.�bֹ��� �[Դaզ���*��\y�8�Է:�Ez\�0�Kq�C b��̘��cө���Q��=0Y��s�N��S.���3.���O�o:���#���v7�[#߫ ��5�܎�L���Er4���9n��COWlG�^��0k�%<���ZB���aB_���������'=��{i�v�l�$�uC���mƎҝ{�c㱼�y]���W�i ��ߧc��m�H� m�"�"�����;Y�ߝ�Z�Ǔ�����:S#��|}�y�,/k�Ld� TA�(�AI$+I3��;Y*���Z��}|��ӧO��d�v��..#:n��f>�>���ȶI�TX��� 8��y����"d�R�|�)0���=���n4��6ⲑ�+��r<�O�܂~zh�z����7ܓ�HH�Ga롏���nCo�>������a ���~]���R���̲c?�6(�q�;5%� |�uj�~z8R=X��I�V=�|{v�Gj\gc��q����z�؋%M�ߍ����1y��#��@f^���^�>N�����#x#۹��6�Y~�?�dfPO��{��P�4��V��u1E1J �*|���%���JN��`eWu�zk M6���q t[�� ��g�G���v��WIG��u_ft����5�j�"�Y�:T��ɐ���*�;� e5���4����q$C��2d�}���� _S�L#m�Yp��O�.�C�;��c����Hi#֩%+) �Ӎ��ƲV���SYź��g |���tj��3�8���r|���V��1#;.SQ�A[���S������#���`n�+���$��$I �P\[�@�s��(�ED�z���P��])8�G#��0B��[ى��X�II�q<��9�~[Z멜�Z�⊔IWU&A>�P~�#��dp<�?����7���c��'~���5 ��+$���lx@�M�dm��n<=e�dyX��?{�|Aef ,|n3�<~z�ƃ�uۧ�����P��Y,�ӥQ�*g�#먙R�\���;T��i,��[9Qi歉����c>]9�� ��"�c��P�� �Md?٥��If�ت�u��k��/����F��9�c*9��Ǎ:�ØF���z�n*�@|I�ށ9����N3{'��[�'ͬ�Ҳ4��#}��!�V� Fu��,�,mTIk���v C�7v���B�6k�T9��1�*l� '~��ƞF��lU��'�M ����][ΩũJ_�{�i�I�n��$���L�� j��O�dx�����kza۪��#�E��Cl����x˘�o�����V���ɞ�ljr��)�/,�߬h�L��#��^��L�ф�,íMƁe�̩�NB�L�����iL����q�}��(��q��6IçJ$�W�E$��:������=#����(�K�B����zђ <��K(�N�۫K�w��^O{!����)�H���>x�������lx�?>Պ�+�>�W���,Ly!_�D���Ō�l���Q�!�[ �S����J��1��Ɛ�Y}��b,+�Lo�x�ɓ)����=�y�oh�@�꥟/��I��ѭ=��P�y9��� �ۍYӘ�e+�p�Jnϱ?V\SO%�(�t� ���=?MR�[Ș�����d�/ ��n�l��B�7j� ��!�;ӥ�/�[-���A�>�dN�sLj ��,ɪv��=1c�.SQ�O3�U���ƀ�ܽ�E����������̻��9G�ϷD�7(�}��Ävӌ\�y�_0[w ���<΍>����a_��[0+�L��F.�޺��f�>oN�T����q;���y\��bՃ��y�jH�<|q-eɏ�_?_9+P���Hp$�����[ux�K w�Mw��N�ی'$Y2�=��q���KB��P��~������Yul:�[<����F1�2�O���5=d����]Y�sw:���Ϯ���E��j,_Q��X��z`H1,#II ��d�wr��P˂@�ZJV����y$�\y�{}��^~���[:N����ߌ�U�������O��d�����ؾe��${p>G��3c���Ė�lʌ�� ת��[��`ϱ�-W����dg�I��ig2��� ��}s ��ؤ(%#sS@���~���3�X�nRG�~\jc3�v��ӍL��M[JB�T��s3}��j�Nʖ��W����;7��ç?=X�F=-�=����q�ߚ���#���='�c��7���ڑW�I(O+=:uxq�������������e2�zi+�kuG�R��������0�&e�n���iT^J����~\jy���p'dtG��s����O��3����9* �b#Ɋ�� p������[Bws�T�>d4�ۧs���nv�n���U���_�~,�v����ƜJ1��s�� �QIz��)�(lv8M���U=�;����56��G���s#�K���MP�=��LvyGd��}�VwWBF�'�à �?MH�U�g2�� ����!�p�7Q��j��ڴ����=��j�u��� Jn�A s���uM������e��Ɔ�Ҕ�!)'��8Ϣ�ٔ��ޝ(��Vp���צ֖d=�IC�J�Ǡ{q������kԭ�߸���i��@K����u�|�p=..�*+����x�����z[Aqġ#s2a�Ɗ���RR�)*HRsi�~�a &f��M��P����-K�L@��Z��Xy�'x�{}��Zm+���:�)�) IJ�-i�u���� ���ܒH��'�L(7�y�GӜq���� j��� 6ߌg1�g�o���,kر���tY�?W,���p���e���f�OQS��!K�۟cҒA�|ս�j�>��=⬒��˧L[�� �߿2JaB~R��u�:��Q�] �0H~���]�7��Ƽ�I���(}��cq '�ήET���q�?f�ab���ӥvr� �)o��-Q��_'����ᴎo��K������;��V���o��%���~OK ����*��b�f:���-ťIR��`B�5!RB@���ï�� �u �̯e\�_U�_������� g�ES��3�������QT��a����x����U<~�c?�*�#]�MW,[8O�a�x��]�1bC|踤�P��lw5V%�)�{t�<��d��5���0i�XSU��m:��Z�┵�i�"��1�^B�-��P�hJ��&)O��*�D��c�W��vM��)����}���P��ܗ-q����\mmζZ-l@�}��a��E�6��F�@��&Sg@���ݚ�M����� ȹ 4����#p�\H����dYDo�H���"��\��..R�B�H�z_�/5˘����6��KhJR��P�mƶi�m���3�,#c�co��q�a)*Pt����R�m�k�7x�D�E�\Y�閣_X�<���~�)���c[[�BP����6�Yq���S��0����%_����;��Àv�~�| VS؇ ��'O0��F0��\���U�-�d@�����7�SJ*z��3n��y��P����O���������m�~�P�3|Y��ʉr#�C�<�G~�.,! ���bqx���h~0=��!ǫ�jy����l�O,�[B��~��|9��ٱ����Xly�#�i�B��g%�S��������tˋ���e���ې��\[d�t)��.+u�|1 ������#�~Oj����hS�%��i.�~X���I�H�m��0n���c�1uE�q��cF�RF�o���7� �O�ꮧ� ���ۛ{��ʛi5�rw?׌#Qn�TW��~?y$��m\�\o����%W� ?=>S�N@�� �Ʈ���R����N�)�r"C�:��:����� �����#��qb��Y�. �6[��2K����2u�Ǧ�HYR��Q�MV��� �G�$��Q+.>�����nNH��q�^��� ����q��mM��V��D�+�-�#*�U�̒ ���p욳��u:�������IB���m���PV@O���r[b= �� ��1U�E��_Nm�yKbN�O���U�}�the�`�|6֮P>�\2�P�V���I�D�i�P�O;�9�r�mAHG�W�S]��J*�_�G��+kP�2����Ka�Z���H�'K�x�W�MZ%�O�YD�Rc+o��?�q��Ghm��d�S�oh�\�D�|:W������UA�Qc yT�q������~^�H��/��#p�CZ���T�I�1�ӏT����4��"�ČZ�����}��`w�#�*,ʹ�� ��0�i��課�Om�*�da��^gJ݅{���l�e9uF#T�ֲ��̲�ٞC"�q���ߍ ոޑ�o#�XZTp����@ o�8��(jd��xw�]�,f���`~�|,s��^����f�1���t��|��m�򸄭/ctr��5s��7�9Q�4�H1꠲BB@l9@���C�����+�wp�xu�£Yc�9��?`@#�o�mH�s2��)�=��2�.�l����jg�9$�Y�S�%*L������R�Y������7Z���,*=�䷘$�������arm�o�ϰ���UW.|�r�uf����IGw�t����Zwo��~5 ��YյhO+=8fF�)�W�7�L9lM�̘·Y���֘YLf�큹�pRF���99.A �"wz��=E\Z���'a� 2��Ǚ�#;�'}�G���*��l��^"q��+2FQ� hj��kŦ��${���ޮ-�T�٭cf�|�3#~�RJ����t��$b�(R��(����r���dx� >U b�&9,>���%E\� Ά�e�$��'�q't��*�א���ެ�b��-|d���SB�O�O��$�R+�H�)�܎�K��1m`;�J�2�Y~9��O�g8=vqD`K[�F)k�[���1m޼c��n���]s�k�z$@��)!I �x՝"v��9=�ZA=`Ɠi �:�E��)`7��vI��}d�YI�_ �o�:ob���o ���3Q��&D&�2=�� �Ά��;>�h����y.*ⅥS������Ӭ�+q&����j|UƧ����}���J0��WW< ۋS�)jQR�j���Ư��rN)�Gű�4Ѷ(�S)Ǣ�8��i��W52���No˓� ۍ%�5brOn�L�;�n��\G����=�^U�dI���8$�&���h��'���+�(������cȁ߫k�l��S^���cƗjԌE�ꭔ��gF���Ȓ��@���}O���*;e�v�WV���YJ\�]X'5��ղ�k�F��b 6R�o՜m��i N�i����>J����?��lPm�U��}>_Z&�KK��q�r��I�D�Չ~�q�3fL�:S�e>���E���-G���{L�6p�e,8��������QI��h��a�Xa��U�A'���ʂ���s�+טIjP�-��y�8ۈZ?J$��W�P� ��R�s�]��|�l(�ԓ��sƊi��o(��S0��Y� 8�T97.�����WiL��c�~�dxc�E|�2!�X�K�Ƙਫ਼�$((�6�~|d9u+�qd�^3�89��Y�6L�.I�����?���iI�q���9�)O/뚅����O���X��X�V��ZF[�یgQ�L��K1���RҖr@v�#��X�l��F���Нy�S�8�7�kF!A��sM���^rkp�jP�DyS$N���q��nxҍ!U�f�!eh�i�2�m���`�Y�I�9r�6� �TF���C}/�y�^���Η���5d�'��9A-��J��>{�_l+�`��A���[�'��յ�ϛ#w:݅�%��X�}�&�PSt�Q�"�-��\縵�/����$Ɨh�Xb�*�y��BS����;W�ջ_mc�����vt?2}1�;qS�d�d~u:2k5�2�R�~�z+|HE!)�Ǟl��7`��0�<�,�2*���Hl-��x�^����'_TV�gZA�'j� ^�2Ϊ��N7t�����?w�� �x1��f��Iz�C-Ȗ��K�^q�;���-W�DvT�7��8�Z�������� hK�(P:��Q- �8�n�Z���܃e貾�<�1�YT<�,�����"�6{/ �?�͟��|1�:�#g��W�>$����d��J��d�B��=��jf[��%rE^��il:��B���x���Sּ�1հ��,�=��*�7 fcG��#q� �eh?��2�7�����,�!7x��6�n�LC�4x��},Geǝ�tC.��vS �F�43��zz\��;QYC,6����~;RYS/6���|2���5���v��T��i����������mlv��������&� �nRh^ejR�LG�f���? �ۉҬܦƩ��|��Ȱ����>3����!v��i�ʯ�>�v��オ�X3e���_1z�Kȗ\<������!�8���V��]��?b�k41�Re��T�q��mz��TiOʦ�Z��Xq���L������q"+���2ۨ��8}�&N7XU7Ap�d�X��~�׿��&4e�o�F��� �H����O���č�c�� 懴�6���͉��+)��v;j��ݷ�� �UV�� i��� j���Y9GdÒJ1��詞�����V?h��l����l�cGs�ځ�������y�Ac�����\V3�? �� ܙg�>qH�S,�E�W�[�㺨�uch�⍸�O�}���a��>�q�6�n6����N6�q������N ! 1AQaq�0@����"2BRb�#Pr���3C`��Scst���$4D���%Td�� ?���N����a��3��m���C���w��������xA�m�q�m���m������$����4n淿t'��C"w��zU=D�\R+w�p+Y�T�&�պ@��ƃ��3ޯ?�Aﶂ��aŘ���@-�����Q�=���9D��ռ�ѻ@��M�V��P��܅�G5�f�Y<�u=,EC)�<�Fy'�"�&�չ�X~f��l�KԆV��?�� �W�N����=(� �;���{�r����ٌ�Y���h{�١������jW����P���Tc�����X�K�r��}���w�R��%��?���E��m�� �Y�q|����\lEE4���r���}�lsI�Y������f�$�=�d�yO����p�����yBj8jU�o�/�S��?�U��*������ˍ�0������u�q�m [�?f����a�� )Q�>����6#������� ?����0UQ����,IX���(6ڵ[�DI�MNލ�c&���υ�j\��X�R|,4��� j������T�hA�e��^���d���b<����n�� �즇�=!���3�^�`j�h�ȓr��jẕ�c�,ٞX����-����a�ﶔ���#�$��]w�O��Ӫ�1y%��L�Y<�wg#�ǝ�̗`�x�xa�t�w��»1���o7o5��>�m뭛C���Uƃߜ}�C���y1Xνm�F8�jI���]����H���ۺиE@I�i;r�8ӭ����V�F�Շ| ��&?�3|x�B�MuS�Ge�=Ӕ�#BE5G�����Y!z��_e��q�р/W>|-�Ci߇�t�1ޯќd�R3�u��g�=0 5��[?�#͏��q�cf���H��{ ?u�=?�?ǯ���}Z��z���hmΔ�BFTW�����<�q�(v� ��!��z���iW]*�J�V�z��gX֧A�q�&��/w���u�gYӘa���; �i=����g:��?2�dž6�ى�k�4�>�Pxs����}������G�9��3 ���)gG�R<>r h�$��'nc�h�P��Bj��J�ҧH� -��N1���N��?��~��}-q!=��_2hc�M��l�vY%UE�@|�v����M2�.Y[|y�"Eï��K�ZF,�ɯ?,q�?v�M 80jx�"�;�9vk�����+ ֧�� �ȺU��?�%�vcV��mA�6��Qg^M����A}�3�nl� QRN�l8�kkn�'�����(��M�7m9و�q���%ޟ���*h$Zk"��$�9��: �?U8�Sl��,,|ɒ��xH(ѷ����Gn�/Q�4�P��G�%��Ա8�N��!� �&�7�;���eKM7�4��9R/%����l�c>�x;������>��C�:�����t��h?aKX�bhe�ᜋ^�$�Iհ �hr7%F$�E��Fd���t��5���+�(M6�t����Ü�UU|zW�=a�Ts�Tg������dqP�Q����b'�m���1{|Y����X�N��b �P~��F^F:����k6�"�j!�� �I�r�`��1&�-$�Bevk:y���#yw��I0��x��=D�4��tU���P�ZH��ڠ底taP��6����b>�xa����Q�#� WeF��ŮNj�p�J* mQ�N����*I�-*�ȩ�F�g�3 �5��V�ʊ�ɮ�a��5F���O@{���NX��?����H�]3��1�Ri_u��������ѕ�� ����0��� F��~��:60�p�͈�S��qX#a�5>���`�o&+�<2�D����: �������ڝ�$�nP���*)�N�|y�Ej�F�5ټ�e���ihy�Z �>���k�bH�a�v��h�-#���!�Po=@k̆IEN��@��}Ll?j�O������߭�ʞ���Q|A07x���wt!xf���I2?Z��<ץ�T���cU�j��]��陎Ltl �}5�ϓ��$�,��O�mˊ�;�@O��jE��j(�ا,��LX���LO���Ц�90�O �.����a��nA���7������j4 ��W��_ٓ���zW�jcB������y՗+EM�)d���N�g6�y1_x��p�$Lv:��9�"z��p���ʙ$��^��JԼ*�ϭ����o���=x�Lj�6�J��u82�A�H�3$�ٕ@�=Vv�]�'�qEz�;I˼��)��=��ɯ���x �/�W(V���p�����$ �m�������u�����񶤑Oqˎ�T����r��㠚x�sr�GC��byp�G��1ߠ�w e�8�$⿄����/�M{*}��W�]˷.�CK\�ުx���/$�WPw���r� |i���&�}�{�X� �>��$-��l���?-z���g����lΆ���(F���h�vS*���b���߲ڡn,|)mrH[���a�3�ר�[1��3o_�U�3�TC�$��(�=�)0�kgP���� ��u�^=��4 �WYCҸ:��vQ�ר�X�à��tk�m,�t*��^�,�}D*� �"(�I��9R����>`�`��[~Q]�#af��i6l��8���6�:,s�s�N6�j"�A4���IuQ��6E,�GnH��zS�HO�uk�5$�I�4��ؤ�Q9�@��C����wp�BGv[]�u�Ov���0I4���\��y�����Q�Ѹ��~>Z��8�T��a��q�ޣ;z��a���/��S��I:�ܫ_�|������>=Z����8:�S��U�I�J��"IY���8%b8���H��:�QO�6�;7�I�S��J��ҌAά3��>c���E+&jf$eC+�z�;��V����� �r���ʺ������my�e���aQ�f&��6�ND��.:��NT�vm�<- u���ǝ\MvZY�N�NT��-A�>jr!S��n�O 1�3�Ns�%�3D@���`������ܟ 1�^c<���� �a�ɽ�̲�Xë#�w�|y�cW�=�9I*H8�p�^(4���՗�k��arOcW�tO�\�ƍR��8����'�K���I�Q�����?5�>[�}��yU�ײ -h��=��% q�ThG�2�)���"ו3]�!kB��*p�FDl�A���,�eEi�H�f�Ps�����5�H:�Փ~�H�0Dت�D�I����h�F3�������c��2���E��9�H��5�zԑ�ʚ�i�X�=:m�xg�hd(�v����׊�9iS��O��d@0ڽ���:�p�5�h-��t�&���X�q�ӕ,��ie�|���7A�2���O%P��E��htj��Y1��w�Ѓ!����  ���� ࢽ��My�7�\�a�@�ţ�J �4�Ȼ�F�@o�̒?4�wx��)��]�P��~�����u�����5�����7X ��9��^ܩ�U;Iꭆ 5 �������eK2�7(�{|��Y׎ �V��\"���Z�1� Z�����}��(�Ǝ"�1S���_�vE30>���p;� ΝD��%x�W�?W?v����o�^V�i�d��r[��/&>�~`�9Wh��y�;���R��� ;;ɮT��?����r$�g1�K����A��C��c��K��l:�'��3 c�ﳯ*"t8�~l��)���m��+U,z��`(�>yJ�?����h>��]��v��ЍG*�{`��;y]��I�T� ;c��NU�fo¾h���/$���|NS���1�S�"�H��V���T���4��uhǜ�]�v;���5�͠x��'C\�SBpl���h}�N����� A�Bx���%��ޭ�l��/����T��w�ʽ]D�=����K���ž�r㻠l4�S�O?=�k �M:� ��c�C�a�#ha���)�ѐxc�s���gP�iG��{+���x���Q���I= �� z��ԫ+ �8"�k�ñ�j=|����c ��y��CF��/��*9ж�h{ �?4�o� ��k�m�Q�N�x��;�Y��4膚�a�w?�6�>e]�����Q�r�:����g�,i"�����ԩA�*M�<�G��b�if��l^M��5� �Ҩ�{����6J��ZJ�����P�*�����Y���ݛu�_4�9�I8�7���������,^ToR���m4�H��?�N�S�ѕw��/S��甍�@�9H�S�T��t�ƻ���ʒU��*{Xs�@����f�����֒Li�K{H�w^���������Ϥm�tq���s� ���ք��f:��o~s��g�r��ט� �S�ѱC�e]�x���a��) ���(b-$(�j>�7q�B?ӕ�F��hV25r[7 Y� }L�R��}����*sg+��x�r�2�U=�*'WS��ZDW]�WǞ�<��叓���{�$�9Ou4��y�90-�1�'*D`�c�^o?(�9��u���ݐ��'PI&� f�Jݮ�������:wS����jfP1F:X �H�9dԯ���˝[�_54 �}*;@�ܨ�� ð�yn�T���?�ןd�#���4rG�ͨ��H�1�|-#���Mr�S3��G�3�����)�.᧏3v�z֑��r����$G"�`j �1t��x0<Ɔ�Wh6�y�6��,œ�Ga��gA����y��b��)��h�D��ß�_�m��ü �gG;��e�v��ݝ�nQ� ��C����-�*��o���y�a��M��I�>�<���]obD��"�:���G�A��-\%LT�8���c�)��+y76���o�Q�#*{�(F�⽕�y����=���rW�\p���۩�c���A���^e6��K������ʐ�cVf5$�'->���ՉN"���F�"�UQ@�f��Gb~��#�&�M=��8�ט�JNu9��D��[̤�s�o�~������ G��9T�tW^g5y$b��Y'��س�Ǵ�=��U-2 #�MC�t(�i� �lj�@Q 5�̣i�*�O����s�x�K�f��}\��M{E�V�{�υ��Ƈ�����);�H����I��fe�Lȣr�2��>��W�I�Ȃ6������i��k�� �5�YOxȺ����>��Y�f5'��|��H+��98pj�n�.O�y�������jY��~��i�w'������l�;�s�2��Y��:'lg�ꥴ)o#'Sa�a�K��Z� �m��}�`169�n���"���x��I ��*+� }F<��cГ���F�P�������ֹ*�PqX�x۩��,� ��N�� �4<-����%����:��7����W���u�`����� $�?�I��&����o��o��`v�>��P��"��l���4��5'�Z�gE���8���?��[�X�7(��.Q�-��*���ތL@̲����v��.5���[��=�t\+�CNܛ��,g�SQnH����}*F�G16���&:�t��4ُ"A��̣��$�b �|����#rs��a�����T�� ]�<�j��BS�('$�ɻ� �wP;�/�n��?�ݜ��x�F��yUn�~mL*-�������Xf�wd^�a�}��f�,=t�׵i�.2/wpN�Ep8�OР���•��R�FJ� 55TZ��T �ɭ�<��]��/�0�r�@�f��V��V����Nz�G��^���7hZi����k��3�,kN�e|�vg�1{9]_i��X5y7� 8e]�U����'�-2,���e"����]ot�I��Y_��n�(JҼ��1�O ]bXc���Nu�No��pS���Q_���_�?i�~�x h5d'�(qw52] ��'ޤ�q��o1�R!���`ywy�A4u���h<קy���\[~�4�\ X�Wt/� 6�����n�F�a8��f���z �3$�t(���q��q�x��^�XWeN'p<-v�!�{�(>ӽDP7��ո0�y)�e$ٕv�Ih'Q�EA�m*�H��RI��=:��� ���4牢) �%_iN�ݧ�l]� �Nt���G��H�L��� ɱ�g<���1V�,�J~�ٹ�"K��Q�� 9�HS�9�?@��k����r�;we݁�]I�!{ �@�G�[�"��`���J:�n]�{�cA�E����V��ʆ���#��U9�6����j�#Y�m\��q�e4h�B�7��C�������d<�?J����1g:ٳ���=Y���D�p�ц� ׈ǔ��1�]26؜oS�'��9�V�FVu�P�h�9�xc�oq�X��p�o�5��Ա5$�9W�V(�[Ak�aY錎qf;�'�[�|���b�6�Ck��)��#a#a˙��8���=äh�4��2��C��4tm^ �n'c���]GQ$[Wҿ��i���vN�{Fu ��1�gx��1┷���N�m��{j-,��x�� Ūm�ЧS�[�s���Gna���䑴�� x�p 8<������97�Q���ϴ�v�aϚG��Rt�Һ׈�f^\r��WH�JU�7Z���y)�vg=����n��4�_)y��D'y�6�]�c�5̪�\� �PF�k����&�c;��cq�$~T�7j ���nç]�<�g ":�to�t}�159�<�/�8������m�b�K#g'I'.W�����6��I/��>v��\�MN��g���m�A�yQL�4u�Lj�j9��#44�t��l^�}L����n��R��!��t��±]��r��h6ٍ>�yҏ�N��fU�� ���� Fm@�8}�/u��jb9������he:A�y�ծw��GpΧh�5����l}�3p468��)U��d��c����;Us/�֔�YX�1�O2��uq�s��`hwg�r~�{ R��mhN��؎*q 42�*th��>�#���E����#��Hv�O����q�}�����6�e��\�,Wk�#���X��b>��p}�դ��3���T5��†��6��[��@�P�y*n��|'f�֧>�lư΂�̺����SU�'*�q�p�_S�����M�� '��c�6�����m�� ySʨ;M��r���Ƌ�m�Kxo,���Gm�P��A�G�:��i��w�9�}M(�^�V��$ǒ�ѽ�9���|���� �a����J�SQ�a���r�B;����}���ٻ֢�2�%U���c�#�g���N�a�ݕ�'�v�[�OY'��3L�3�;,p�]@�S��{ls��X�'���c�jw�k'a�.��}�}&�� �dP�*�bK=ɍ!����;3n�gΊU�ߴmt�'*{,=SzfD� A��ko~�G�aoq�_mi}#�m�������P�Xhύ����mxǍ�΂���巿zf��Q���c���|kc�����?���W��Y�$���_Lv����l߶��c���`?����l�j�ݲˏ!V��6����U�Ђ(A���4y)H���p�Z_�x��>���e��R��$�/�`^'3qˏ�-&Q�=?��CFVR �D�fV�9��{�8g�������n�h�(P"��6�[�D���< E�����~0<@�`�G�6����Hг�cc�� �c�K.5��D��d�B���`?�XQ��2��ٿyqo&+�1^� DW�0�ꊩ���G�#��Q�nL3��c���������/��x ��1�1[y�x�პCW��C�c�UĨ80�m�e�4.{�m��u���I=��f�����0QRls9���f���������9���~f�����Ǩ��a�"@�8���ȁ�Q����#c�ic������G��$���G���r/$W�(��W���V�"��m�7�[m�A�m����bo��D� j����۳� l���^�k�h׽����� ��#� iXn�v��eT�k�a�^Y�4�BN��ĕ��0 !01@Q"2AaPq3BR������?���@4�Q�����T3,���㺠�W�[=JK�Ϟ���2�r^7��vc�:�9 �E�ߴ�w�S#d���Ix��u��:��Hp��9E!�� V 2;73|F��9Y���*ʬ�F��D����u&���y؟��^EA��A��(ɩ���^��GV:ݜDy�`��Jr29ܾ�㝉��[���E;Fzx��YG��U�e�Y�C���� ����v-tx����I�sם�Ę�q��Eb�+P\ :>�i�C'�;�����k|z�رn�y]�#ǿb��Q��������w�����(�r|ӹs��[�D��2v-%��@;�8<a���[\o[ϧw��I!��*0�krs)�[�J9^��ʜ��p1)� "��/_>��o��<1����A�E�y^�C��`�x1'ܣn�p��s`l���fQ��):�l����b>�Me�jH^?�kl3(�z:���1ŠK&?Q�~�{�ٺ�h�y���/�[��V�|6��}�KbX����mn[-��7�5q�94�������dm���c^���h� X��5��<�eޘ>G���-�}�دB�ޟ� ��|�rt�M��V+�]�c?�-#ڛ��^ǂ}���Lkr���O��u�>�-D�ry� D?:ޞ�U��ǜ�7�V��?瓮�"�#���r��չģVR;�n���/_� ؉v�ݶe5d�b9��/O��009�G���5n�W����JpA�*�r9�>�1��.[t���s�F���nQ� V 77R�]�ɫ8����_0<՜�IF�u(v��4��F�k�3��E)��N:��yڮe��P�`�1}�$WS��J�SQ�N�j�ٺ��޵�#l���ј(�5=��5�lǏmoW�v-�1����v,W�mn��߀$x�<����v�j(����c]��@#��1������Ǔ���o'��u+����;G�#�޸��v-lη��/(`i⣍Pm^���ԯ̾9Z��F��������n��1��� ��]�[��)�'������:�֪�W��FC����� �B9،!?���]��V��A�Վ�M��b�w��G F>_DȬ0¤�#�QR�[V��kz���m�w�"��9ZG�7'[��=�Q����j8R?�zf�\a�=��O�U����*oB�A�|G���2�54 �p��.w7� �� ��&������ξxGHp� B%��$g�����t�Џ򤵍z���HN�u�Я�-�'4��0��;_��3 !01"@AQa2Pq#3BR������?��ʩca��en��^��8���<�u#��m*08r��y�N"�<�Ѳ0��@\�p��� �����Kv�D��J8�Fҽ� �f�Y��-m�ybX�NP����}�!*8t(�OqѢ��Q�wW�K��ZD��Δ^e��!� ��B�K��p~�����e*l}z#9ң�k���q#�Ft�o��S�R����-�w�!�S���Ӥß|M�l޶V��!eˈ�8Y���c�ЮM2��tk���� ������J�fS����Ö*i/2�����n]�k�\���|4yX�8��U�P.���Ы[���l��@"�t�<������5�lF���vU�����W��W��;�b�cД^6[#7@vU�xgZv��F�6��Q,K�v��� �+Ъ��n��Ǣ��Ft���8��0��c�@�!�Zq s�v�t�;#](B��-�nῃ~���3g������5�J�%���O������n�kB�ĺ�.r��+���#�N$?�q�/�s�6��p��a����a��J/��M�8��6�ܰ"�*������ɗud"\w���aT(����[��F��U՛����RT�b���n�*��6���O��SJ�.�ij<�v�MT��R\c��5l�sZB>F��<7�;EA��{��E���Ö��1U/�#��d1�a�n.1ě����0�ʾR�h��|�R��Ao�3�m3 ��%�� ���28Q� ��y��φ���H�To�7�lW>����#i`�q���c����a��� �m,B�-j����݋�'mR1Ήt�>��V��p���s�0IbI�C.���1R�ea�����]H�6����������4B>��o��](��$B���m�����a�!=��?�B� K�Ǿ+�Ծ"�n���K��*��+��[T#�{E�J�S����Q�����s�5�:�U�\wĐ�f�3����܆&�)����I���Ԇw��E T�lrTf6Q|R�h:��[K�� �z��c֧�G�C��%\��_�a�84��HcO�bi��ؖV��7H �)*ģK~Xhչ0��4?�0��� �E<���}3���#���u�?�� ��|g�S�6ꊤ�|�I#Hڛ� �ա��w�X��9��7���Ŀ%�SL��y6č��|�F�a 8���b��$�sק�h���b9RAu7�˨p�Č�_\*w��묦��F ����4D~�f����|(�"m���NK��i�S�>�$d7SlA��/�²����SL��|6N�}���S�˯���g��]6��; �#�.��<���q'Q�1|KQ$�����񛩶"�$r�b:���N8�w@��8$�� �AjfG|~�9F ���Y��ʺ��Bwؒ������M:I岎�G��`s�YV5����6��A �b:�W���G�q%l�����F��H���7�������Fsv7��k�� 403WebShell
403Webshell
Server IP : 104.21.45.146  /  Your IP : 172.69.130.106
Web Server : Apache/2.4.52 (Ubuntu)
System : Linux ip-172-31-19-221 6.8.0-1029-aws #31~22.04.1-Ubuntu SMP Thu Apr 24 21:16:18 UTC 2025 x86_64
User : www-data ( 33)
PHP Version : 8.1.28
Disable Function : NONE
MySQL : OFF  |  cURL : ON  |  WGET : ON  |  Perl : ON  |  Python : OFF  |  Sudo : ON  |  Pkexec : ON
Directory :  /efsdata/scitechnol.com/httpdocs/submission/uploads/

Upload File :
current_dir [ Writeable ] document_root [ Writeable ]

 

Command :


[ Back ]     

Current File : /efsdata/scitechnol.com/httpdocs/submission/uploads/279-0-Manuscript-2013-01-02.doc
��ࡱ�>��	`b����_d�������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������	��̓bjbj���	4�����hQz���������AAAAA����UUU8��A�U5���YoooJ�<P J4L4L4L4L4L4L4$�6��9�p4QApJJppp4AAoo��4>">">"p�AoAoJ4>"pJ4>">"�v-hj.o���������Un ��-64�405�-|W:h!�W: j.j.PW:A�0|pp>"pppppp4p4>"ppp5pppp��������������������������������������������������������������������W:ppppppppp�	:	The use of synthetic cathionones and tryptamines in a psychiatric population 

L. J Reidy Ph.D1, P. Junquera M.D 2, K. R. Van Dijck MSc1, B.W Steele M.D1 and lhsan M.Salloum2
1University of Miami, Department of Pathology, University of Miami Forensic Toxicology Laboratory, 1600 NW, 10th avenue, RSMB, R-7020A.  2University of Miami, Department of Psychiatry and Behavioral sciences

Introduction
A new wave of designer drugs is emerging in both emergency room (ER) patients and the community at large.  These drugs commonly known and sold as �bath salts� produce toxic effects as well as disturbing psychopathological symptoms. These drugs are synthetic modification of the naturally occurring alkaloid cathinone, which can be extracted from the leaves of Catha Edulis, commonly known as the khat plant [1].  The synthetic cathinones such as methylone; 3,4 methylendioxyprovalerone (MDPV); mephedrone; and ethylone (Figure 1) are commonly sold under various names such as �Ivory Wave�, �Vanilla Sky� and �Bliss�.  
The prevalence of use of these drugs is likely to be largely underestimated due to the lack of testing and to the perception of unavailability of testing methodologies.  The American Association of Poison Control Centers (AAPCC) reported a dramatic increase of bath salt related calls from 303 calls in 2010 to 6,072 calls in 2011 [2].
These drugs have amphetamines-like effects. They enhance the synaptic activation of biogenic amines such as norephinephrine, dopamine and serotonin either by inhibiting their re-uptake, or by stimulating their release from storage vesicles [3].  Users report a variety of psychedelic effects including a sense of well being, a sense of profound insight and introspection, closed and open eyed visuals, increased appreciation of music and emphathogensis.  Effects on the body include increased blood pressure, blurred vision, dehydration, nausea, vomiting, dilated pupils and tachycardia. The observed peripheral cardiovascular effects are largely due to norephinephrine that is also thought to contribute to the alerting, locomotors stimulation and anorexic effects seen with these drugs [4].  
The development of psychosis and hallucinations has been attributed to the effects of serotonin. The development of psychosis may require the intake of higher doses as the affinity of these drugs for the serotonergic receptors is estimated to be three times weaker than that of MDMA.  A recent report described two patients with no previous history of psychiatric illness who were admitted to the emergency room with bath salt intoxication delirium and intense psychosis [5].  
The second group of drugs described in this paper is the tryptamines. Tryptamines are well known for their psychoactive properties and have been used for centuries, especially in the context of religious rituals and folk medicine [6].  The tryptamines discussed in this paper are a group of psychedelic substances primarily regarded for their hallucinogenic properties.  Tryptamines are found naturally in plants (e.g. DMT (N, N-Dimethyltryptamine, the active component of the ayahuasca brews often derived from the chacruna plant), fungi (e.g psilocybin from "magic mushrooms") and animals. Commonly known tryptamines include LSD and psilocybin. However, there are also many synthetic tryptamines such as DMT, AMT and 5MEODiPT. This group of compounds has been extensively studied and described in Alexander Shulgin�s TIKHAL (Tryptamines I Have Known and Loved) [7].   The internet has facilitated the illicit use of these various tryptamines and synthetic cathinones in recent years.  Various web sites offer information on where to buy these drugs and about where to find plants that naturally contain a tryptamines and how to extract them [6].  Effects of some of these tryptamines include euphoria, dilated pupils, empathy, nausea, vomiting and diarrhea [8, 9].
There is inadequate published literature on the pharmacology or toxicology of most of these psychedelic compounds. Hadlock et al [10] demonstrated that mephedrone has a unique pharmacological profile different from MDMA (3, 4-methylenedioxy-N-methylamphetamine), known on the streets as �ecstasy� or �molly� and from methamphetamine.  Mephedrone has been shown to cause greater dopamine (DA) release than MDMA; hence it may have higher abuse liability.  Information regarding synthetic cathinone abuse liability and neurotoxin potential are generally lacking. 
These recreational drugs are not routinely tested by clinical laboratories due to financial constraints, analytical capabilities and time limitations. Thus, the presence and the rate of these drugs in patients presenting for care is still largely unexplored. This is especially true for patients presenting for psychiatric care, as it is unclear how many of those presenting for psychiatric care may be wrongly diagnoses with primary psychotic disorder while their symptoms may be due to the abuse of these substances. It is also unclear how frequent the abuse of these drugs among psychiatric patients in general and what is the impact of their use on symptoms exacerbation and emergency use care for this population. We conducted a simple and efficient urine drug screen aimed at identifying the presence and incidence level of these �designer drugs� in an inner-city, psychiatric emergency department. 

Study Design
This protocol was approved by the Institutional Review Board (IRB) of the University of Miami.   The study sample consisted of consecutive patients who were admitted to the inpatient detoxification unit of an inner city community hospital over a three month period and provided a urine sample.  Patients were tested by routine clinical toxicology at the hospital laboratory and then re-analyzed at the toxicology laboratory at the University of Miami.   In total, 209 unique patient urine samples were analyzed.  The sample group was comprised of 71% males and 29% females, 19% of them were between the ages 18-25, and 34% were between 25-40 and the remainder over 40 years old.   We were provided with de-identified samples with patient demographics (age and gender), clinical toxicology results and clinical diagnosis. 

Toxicology analysis
Apparatus 
GC-MS analysis was performed on an Agilent 7890 GC coupled to a 5975 MS.  The mass selective detector operated in electron impact mode.  The electron multiplier was set 200 volts relative to the auto tune value.  The GC was fitted with a Agilent column (15 M x 0.25 mm i.d x 0.25 �m d.f.) fitted with a dean switch operating in split less mode (bottom gooseneck liner with no glass wool) with helium as the carrier gas operated in constant pressure of 31.49 psi and an injection volume of 1 �L. The injector and detector temperatures were 280�C and 300�C, respectively. The initial oven temperature was held at 100�C for 0.5 min, and then ramped at 40�C/min to 325�C with a hold time of 2 min (total run time 7 min).   The GC is fitted with two detectors, a nitrogen phosphorous detector (NPD) and mass spectrometer (MS).
The MS was operated in the full scan mode (40�600 amu) and data was acquired and analyzed using Agilent ChemStation� software version G1701 EA revision no: E02.02 and Agilent DRS software G1716 AA revision no: A.04.00 (Santa Clara, CA) and running the AMDIS deconvolution software using a library of over 750 compounds.  All solvents were Sigma Aldrich (Sigma-Aldrich Co. LLC St. Louis, MO) HPLC-grade or equivalent. 

Materials and Method
Methylone, ethylone, MDPV, mephedrone, buphedrone, methcathionine were purchased from Cerilliant Corporation (Round Rock, TX).  Dimethyltryptamine, dipropyltrytamine, 5-methoxy-alpra-methtryptamine, diisopropylatramine and 5-methoxy-dipropylatyptamine) were purchased from Alltech (Deerfield, IL).

Analysis protocol
All samples were extracted using a Basic Drug Screen (BDS) and subjected to gas chromatography mass spectral (GC-MS) analysis. This is a quick extraction and able to quantify a large number of these synthetic drugs.   Individual stock standards of methylone, MDPV, ethylone, and various tryptamines were analyzed via GC-MS to determine the mass spectral profile, retention time and limit of detection (LOD).     

BDS by GC-MS
The GC-MS screening for drugs in urine was conducted with an alkaline liquid-liquid extraction, with modifications to the published procedure by Forester et al [11].  Briefly, urine aliquots (2 mL) were dispensed into 17 mL silanized screw cap tubes.  The internal standard (n-propylamphetaime, cyclizine, ethyl morphine, prazepam) was added to each tube of urine to give a final concentration of 500ng/mL.  To each tube 9 mL of n-butyl chloride: methylene chloride (9:1) was added and briefly vortexed.  1mL of concentrated ammonium hydroxide (33%) was added to each tube, and the tube was sealed with a Teflon lined cap.  The samples were then extracted on a rotor rack for 15 min.  Tubes were centrifuged at 3800 rpm for 10 min at -10�C to produce separation and the organic layer transferred to a silanized conical tube and evaporated to just dryness in a TurboVap � at 50�C under a stream of nitrogen.  The dry urine extract was reconstituted with 50 �L isooctane: methylene chloride: ethanol (7:2:1); and subsequently transferred to limited volume auto-sampler vials; and analyzed via GC-MS in scan mode. Positive and negative controls were prepared in-house and interferences were investigated by running blank and negative urine controls. 

Results
The results of the drug fortified urine samples are presented in Table 1.  Methylone and ethylone yielded similar mass spectra data; however they were separated based upon their respective retention times. The limit of detection (LOD) for the synthetic cathinones was 50ng/mL and the LOD for the tryptamines compounds was 25ng/mL.  
Three patients from the 209 samples analyzed confirmed positive for one or more of these synthetic compounds. We present the clinical and toxicological data for each patient below.  

Patient 1
Patient 1 presented to the psychiatric emergency department with severe stomach discomfort and alcohol intoxication.  Admission toxicology testing by the hospital toxicology laboratory reported a presumptive positive for amphetamines (class) drug and negative for 4 other immunoassays (cocaine metabolite, opiates, benzodiazepines, cannabinoids).  Urine analysis test by ELISA screened positive for amphetamine (class), methamphetamine / MDMA (class) and confirmed positive results for amphetamine, methamphetamine, and venflaxaine and metabolites. More interestingly, it also confirmed positive result for 5-Me-O-DiPT and dimethyldipropylatrytamine. In a typical clinical laboratory testing, the drugs in the tryptamines family would not have been identified, as a commercial ELISA or EIA kit is not available for the tryptamines groups. One of the side effects of 5-Me-O-DiPT is gastrointestinal distress, which was a prominent symptom of this patient�s presentation [7]. 


Patient 2
Patient 2 was a male, in the age range 25 � 40yrs who voluntarily presented to the ER with a psychiatric episode; he had previously been diagnosed and treated for paranoid schizophrenia.  The patient was extremely agitated and showed aggression.  The patient�s urine clinical toxicology report was found to be negative upon admission by the hospital laboratory immunoassay or all five drug classes.  Analysis of the alkaline extract by GC-MS detected the use of methylone, one of the �bath salts� active ingredients, and also diethyltryptamine.   Simultaneous use of these drugs will produce a profound effect on the brain [7, 8]. The alkaline extract also identified recent use of citalopram, haloperidol, dextromethorphan, promethazine and temazepam.

Patient 3
Patient 3 was a female over the age of 40 who was admitted to the psychiatric ward due to auditory hallucinations, acute psychosis and seizure disorder. There was no reported history of psychiatric disorders.  Her admission toxicology immunoassay screen was negative for all drugs tested (amphetamines, benzoylecgonine, opiates, cannabinoids, and benzodiazepines).  Analysis by the alkaline extract using GC-MS detected the use of methylone, diphenhydramine, citalopram and haloperidol.  

Discussion
Out of the 209 urine samples tested, 3 samples (1.5%) were positive for one or more of these new designer psychoactive compounds that would have been missed in a routine clinical laboratory tests.  Previous papers detailing the effects of these new designer drugs on patients has been largely focused on patients admission to using one or more of these drugs [4]. This is the first paper, to the author�s knowledge, that correlates the toxicology with the admission findings of four different compounds.   Recent papers have identified mephedrone as the drug of choice in �bath salt� preparation [12] however in this study methylone the only �bath salt� was found in these samples.
While only 1.5% was positive for �designer drug� use, each case highlights an important argument to attempt to include these tests in routine emergency room screen. This is largely attributed to the profound psychological effects that these drugs may have on an individual.  The potential etiology of Patient 1 gastrointestinal distress would have been completely missed using routing urine screening tests. The results obtained in patient 2 clearly raises the question of whether the psychiatric diagnosis of bipolar disorder is correct and whether the psychiatric symptoms presenting for this patient are all due to this previously unrecognized drug use. If this patient has a verified bipolar diagnosis, it is unclear how much this diagnosis was exacerbated by the use of these drugs as well. Similar questions are raised by patient 3. 
The implications of a misdiagnosis could be far reaching. Usually a diagnosis of bipolar disorder or of schizophrenia requires life-long treatment with psychotropic medications. Therefore, the ability to rule out drug induced symptoms is crucial for the long term care for these patients.  It is equally important for the care of patients with chronic psychiatric disorders is the ability to identify precipitating and exacerbating factors, most frequent among them is unrecognized substance abuse. The pharmacodynamics effects of these amphetamine-like drugs produce symptoms that mimic both psychosis and mania. These drugs also exacerbate these manic, psychotic and other mood symptoms in patients who suffer from these disorders. The alkaline extract analysis by GC-MS is comprehensive, quick and cost effective urine toxicology which helps to clarify the presenting diagnostic picture, which is a crucial first step for implementing effective treatment plans. Typically drugs screens are thought of as immunoassay and are too targeted and expensive.  However by utilizing GC-MS, the cost can be reduced to about $100 for analysis of over 750 compounds in one analysis so therefore is extremely cost effective.  With the development of LC-MS-MS screening this cost can be reduced further again as sample preparation is less time consuming and labor intensive enabling this type of testing as a potential tool for clinicians.  
Limitations of this study include its pilot exploratory nature and the nature of the population tested which may limit its generalizability to other settings or patient populations. The results of this study however, highlight the need for larger studies to systematically assess the frequency and impact of �designer drugs� abuse on patients presenting for psychiatric care.    
The impact that these �new� designer drugs are having on a community as a whole is largely unknown at this point. The long term negative outcomes such as cognitive impairment, drug dependence and mental health disorders, associated with the use of tryptamines and synthetic cathinones are unknown.  Cognitive impairment and neurological toxicity impairment for instance has been associated with the more common tryptamines and pheneylamines such as MDMA and LSD, although these studies are somewhat disputed [14, 15]. Patients with psychiatric disorders may be more at risk of having a psychotic episode when using these drugs.  This paper highlights the need for comprehensive toxicology testing when treating psychiatric patients as the presentation of their symptoms and behavior may not be due to a schizophrenic or psychotic episode but may be due to drug use.  With only conventional hospital toxicology testing there may be a considerable lack of toxicology information which may alter the way a patient is treated.  























References 

1) Advisory Council on the Misuse of Drugs (2010) Consideration of the Cathinones.  HYPERLINK "http://drugs.homeoffice.gov.uk/publication-search/acmd/ACMD-cathinones-report.html" http://drugs.homeoffice.gov.uk/publication-search/acmd/ACMD-cathinones-report.html (accessed 10/12/2012)

2) American Association of Poison Control Centers (AAPCC) (2011)  HYPERLINK "http://www.aapcc.org.dnn/Portals/0/Bath%20Salts%20data%20for%20Websites%201.5.2012.pdf" http://www.aapcc.org.dnn/Portals/0/Bath%20Salts%20data%20for%20Websites%201.5.2012.pdf.  Accessed 7/16/2012

3) NV Cozzi, MK Sievert, AT Shulgin, P Jacob III, AE Ruoho (1998) Methcathinone and 2 methylamino-1-(3, 4-methylenedioxyphenyl) propan-1-one (methylone) selectively inhibit plasma membrane catecholamine reuptake transporters Soc. Neurosci. Abs  24  : 341-348
4) Coppola M and Mondola R (2011) 3, 4-methylenedioxypyrovalerone (MDPV) : Chemistry, pharmacology and toxicology of a new designer drug of abuse marketed online. Toxicology Letters
5) Kascik P D., McKnight C A., Klisovic E (2012) �Bath Salt� Ingestion leading to sever Intoxication Delirium: Two cases and a brief review of the emergence of mephedrone use. The American Journal of Drug and Alcohol Abuse 38:176-180 

6) Halpern JH (2004). Hallucinogens and dissociative agents naturally growing in the United States. Pharmacology Therapeutics. 102 (2):131�138.�

7) Shulgin and A. Shulgin (1991) Phenethylamines I Have Known and Loved (PiHKAL): A chemical love story. Transform press, Berkeley, CA, 1991

8) Shulgin A T, Carter M F (1980) N,N-diisopropyltryptamine (DIPT) and 5-methoxy-N,N-diisopropyltryptamine (5-MEO-DIPT). Two orally active tryptamine analogs with CNS activity Communications in psychopharmacology. 4:5; 363-369
9) Muller A A (2004) New drugs of abuse update: Foxy-methoxy. Journal of emergency nurse. 30 507-508

10) Atkinson RM (1973) Importance of alcohol and drug abuse in psychiatric emergencies. Calif Med 118:1-4

11) Hadlock G C,  HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed?term=Webb%20KM%5BAuthor%5D&cauthor=true&cauthor_uid=21810934" Webb K M,  HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed?term=McFadden%20LM%5BAuthor%5D&cauthor=true&cauthor_uid=21810934" McFadden L M,  HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed?term=Chu%20PW%5BAuthor%5D&cauthor=true&cauthor_uid=21810934" Chu P W,  HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed?term=Ellis%20JD%5BAuthor%5D&cauthor=true&cauthor_uid=21810934" Ellis J D, et al (2011)  4-Methylmethcathinone (mephedrone): neuropharmacological effects of a designer stimulant of abuse.  HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed/21810934" \o "The Journal of pharmacology and experimental therapeutics." J Pharmacol Exp Ther. 339 (2): 530-6

12) Forester EH, Hatchet D, Garriott JC (1978). A rapid comprehensive screening procedure for basic drugs in blood or tissue by gas chromatography. Journal of Analytical Toxicology. 2:50-55
13) Spiller H A., Ryan M L., Weston R G., Jansen J (2011) Clinical experience with and analytical confirmation of "bath salts" and "legal highs" (synthetic cathinones) in the United States. Clinical Toxicology 49:6; 499-5
14) Check E (2004). The ups and downs of ecstasy. Nature 429: 126-128
15) Kalent H (2001) The pharmacology and toxicology of �ecstasy�: (MDMA) and related drugs. /MNOQSY^_lpqr����������������				8	9	O	\	]	f	l	}	~		�	������������������ٺ��Ʈ����������}�}w}�q�}
h�T�^J
h}�^J
h�<^Jh�4�h�4�H*^J
h3}�^Jh�11h�4�^Jh�11h3}�^Jh�11h3J�^J
h3J�^J
h�8�^J
h�4�^J
hI�^J
h�4�H*^J
h�>�^J
h2G�^Jh�qh2G�^Jh2G�5�\�^Jh�T�5�\�^Jh�qh2G�5�\�^J,NO�	�	�	�H
cA4e���3 4 H S l&(���������������������$��dh`��a$gdd%�$��dh`��a$gd�}�$dh1$7$8$H$a$gd�}�$dha$gd�}�m$
$dha$gd�}��	�
'+=>BJKTVx{����
cf
$
5
;
F
G
�
�
7;��<_`bc����������$'9=A�����������������������������������ݾ�ݳݯ��������������
h{R�^Jh�H�h{R�hh~_h2G�hRk�h��h2G�h�&h�q�h�6�hXh�1�h3}�h2G�h�qh2G�^J
h�6�^Jh�Y�h2G�6�^J
h2G�^J@�����&+,-���������'-.EMS[\akr��������������������ƺ�ƺ�����������Ռ�����}umu�h3}�mH	sH	hG$mH	sH	h3}�h]M�h]M�mH	sH	h]M�mH	sH	h�jNh]M�mH	sH	h]M�\�mH	sH	h�1�\�mH	sH	h��\�mH	sH	h]M�h]M�\�mH	sH	h]M�h]M�6�\�]�mH	sH	h(�hM�hG$h�omH	sH	h�%qh�aIh�L�h]M�h�8�h]M�*����DFuv��������	PU����/0234�������
%������������������������������ݨ�����ݘ��x�h\�mH	sH	h�1�h�1�\�mH	sH	h�1�h�1�mH	sH	h�1�h�1�h
	h�BO6�h*8�h2G�6�h
2�hd%�h�P=h�Arh?pSh�(Th�%q	h�BOH*h�BOh�gh�1�h2G�hM�hM�mH	sH	h]M�mH	sH	h�jNh]M�mH	sH	,%&89glq����������������de��������j�����������������������������ɺɳ�����������������|
h'TQ5�^J
hI�^J
h�n�^J
h
^J
h�j5^J
h�Y�^J
h��^J
h�jN^J
h2G�^Jhd%�h2G�h�1�h�1�h�BOhh�1�h2G�h�1�mH	sH	h�1�h�1�mH	sH	h�1�h�1�\�mH	sH	h�1�h�1�6�\�]�mH	sH	,��.?]^ag|���!$%,|��������������$()�������������ſŶ��������������vmv�g�g
h�^Jh%<�h�/^Jh%<�h�5'^Jh%<�h�^Jh%<�h%<�^J
hrA�5�^J
ht^Jh%<�hrA�^Jh%<�ht^J
hU~�^Jh%<�h2G�^J
h�n�^J
h�/^J
hC]^J
h�!^Jh�qh2G�^J
htm^J
h
^Jh�qh�j5^JhLhyh2G�5�^J')9:;>FKdjlq� 2 3 4 H Q S �&�&�&U'u'�'�'((($(9(=(e(�(�(�(�(����������������ʙ�ʢʢʢ���}t�k�e
h�8J^Jh�qhe3}^Jhe3}\�mH	sH	h':r\�mH	sH	
h�X4^J
h2G�5�^J
h�<^Jh�qh�<^J
h2G�^JhLhyh2G�5�^J
h�T5�^J
h$�5�^Jh�P=h2G�5�^Jh�qh2G�^J
h�n�^J
h�T^J
h��^J
h�^Jh%<�h2G�^J
h�8�^J
h':r^J$(($(N)O)a)�*�*+�0�0�0B2�2�23�6�6�6�6�9�9�9�;�;������������������������
$dha$gd�}�$dh1$7$8$H$a$gd�s|$dh1$7$8$H$a$gd�}��(�(�(�(�(�(�(�(�(�(�(5)<)L)M)O)`)a)e)�)�)�)�)�)�)�)�)�)�)�)�):*t*�*�*�*�*�*�*�*++j+k+�+�+�����������ľ����ħħ���������~�th
i�h2G�6�^J
h2G�^Jh�8Jh2G�5�^J
h�N5�^J
h(^J
hPJF^J
h�!^J
h�T^Jh,D�h2G�5�^J
h�T5�^J
h�-^J
h�N^J
h�X4^J
h|"^J
hLp�^J
h;-W^J
h��^J
h�8J^Jh�qh2G�^Jh�qh�8J^J-�+�+�+�+�+�+�,�,\.b.�.�.^/�/a0b0�0�0�0�01%1(1=1>1?1t1x1y1�1�1�1�1�1222	272>2?2A2B2G2Q2n2o2�����������¾���������������}��}�y����uh&?�hCh	@�h�RSh	@�h\�h	@�h�	�h	@�hA#$h	@�h2G�h	@�h�h	@�h2G�h�Sh�	�h�h2G�hPJFh��h2G�5�h�s|h�s|^J
h""�^J
h�-^J
h�BO^J
h2G�^J
h�!^J
h
2�^Jh�qh2G�^J.o2�2�2�2�2�2�2�233?3@3�3�34N4]4`4a4f4o4s4�4�4�4�4�4�4�4�4555'5*5;5?5^5c5o5r5�5�566B6I6K6N6�6�6�6�6�6�6���������������ſݿ�Ź�ѿݿݿ�ѿݿ׿��ݧݡݡݘݒ����
h�s|^J
h�8J^Jh�Rh2G�^J
h�1
^J
h�^J
h@W�^J
h�Y/^J
h�y�^J
hXi�^J
h_f�^J
hIO�^J
h�v^J
hl5�^J
h2G�^Jh�qh2G�^J	h2G�5�h&?�h2
h�h2G�6�6�6�677H7P7X7�7�7�7�7,8G8S8o8�8�8�8�8�8�899"999M9S9T9U9V9p9�9�9�9�9:t:�:�:�:�:�:�:�:�:
;��������������ľ�����Ě�������|
hQg�^J
h�8J^J
h�RS^J
h�0!^J
h�x$^J
h�k,^J
h�s|^J
h�^J
h�F�^J
h�ON^J
h�x�^J
h�v�^J
h�)�^J
h�1w^J
h$�^J
h9
^J
h�z�^J
hva�^J
h�0^J
h�US^J
h2G�^J
h""�^J.
;;6;E;F;G;I;o;;�;�;�;�;�;<<r<y<z<�<�<�<6=:=;=<=�=>#>'>I>a>y>z>�>�>�>�>�>�������������ý÷�ñë��������{��uouiu
h��^J
h@W�^J
h�"�^J
h�%�^J
h�R�^J
h
2�^J
h�S^J
hRp}^J
hfY�^J
h��^J
h�x�^J
hBc^J
h�8�^J
h��^J
h�^J
h�8�^Jh�8Jh2G�5�^Jh�qh2G�^J
h�RS^J
h2G�^J
hQg�^J
h4L�^J
h�8J^J
h�@�^J&�;�;z>�AYG�H�L�L�L�L�L�L�L�L�L�L�L�L�L�L�L�L�L�L�L������������������������$a$gd#W�$��dh`��a$gd�x�$��dh`��a$gd�}�
$dha$gd�}��>�>�>�>?}??�?�?�?*B7B�C�C�C&D9DJDjD�D�D�D�DE	EElEvE�E�E�E�E�EXG�H(IFIGI�I�IJ
J+J>JFJ�J�J�J�J�JJK�L����������������������ľ��ָ����ʫ����������������h�X�hC]h�U�h%�he3}hCh	@�hYih�}�h�Th2G�
h�_^J
h�P^J
h�J�^J
h�U-^J
h�^J
h�S^J
h�U^J
h$�^J
hq^J
hsW�^J
h@W�^J
h�"�^J
hZ^J3�L�L�L�L�L�L�LMMMMNM�M�MNNNNNDNTN[N\N�N�NOO.O/O2OJOpO�O�O�O�OPP#P��������������Ⱦ����������yoy�y�yobhYW�6�]�^JmH	sH	h�R�^JmH	sH	h�=h�aI^JmH	sH	h�aI^JmH	sH	h�aIB*^Jphha�h5�0J^Jjh5�B*U^Jphh�mB*^Jphh5�B*^Jphh�q�h�r3h�"c0Jjh�"cUh�11h�"ch5�h
2�
h-pf^Jh�qh2G�^Jh2G�%�L�L�L�L�L�L�L�LNN.O/O2P�P�Q�QeRfR�R�R�S<T=T�T������������������������[$gd�a�$7$8$H$a$gd#W�$�d�d[$\$a$gd#W�$a$gd�"c$a$gd#W�#P&P1P2P4P5PTPVPWP�P�P�P�P�PQ�Q�Q�Q�Q�Q�Q�Q�Q�Q�Q����Ⱦ���������u�qmiS@$hv�B*^JfHphq�
����*h�h�B*^JfHphq�
����h�aIh{R�h�q�h�R�B*^Jphhu �B*^Jphh��B*^Jphh{R�B*^Jphh�aIh�H�^JmH	sH	h�R�^JmH	sH	h�H�^JmH	sH	h�k^JmH	sH	h}3�^JmH	sH	h{R�^JmH	sH	h��^JmH	sH	hYW�^JmH	sH	h�=h�aI6�]�^JmH	sH	�Q7R8RRRSRVRWRcRdReR�׷�z]?'h�h�aI^J.h�h�0J"B*^JfHphq�
����;h�h�B*^Jeh@fHphq�
����r��@9hv�0J#B*^Jeh@fHphq�
����r��@?h�h�0J#B*^Jeh@fHphq�
����r��@9hv�0J!B*^Jeh@fHphq�
����r��@?h�h�0J!B*^Jeh@fHphq�
����r��@$hv�B*^JfHphq�
����*h�h�B*^JfHphq�
����	eRfRgRiRuR�R�R�R�R�R�RS�S�S�S�S�S�S�S;T?TATST���������ª��r�\VPJVD>
hu �^J
h�x�^J
hT}B^J
h�a�^J
h
2�^J+h�a�h
2�5�CJOJQJ^JaJmH	sH	%h%�5�CJOJQJ^JaJmH	sH	%h�a�5�CJOJQJ^JaJmH	sH	#h�%�h�a�5�CJOJQJ^JaJ.h�a�5�B*CJOJQJ^JaJmH	phsH	h�a�^JmH	sH	+h�a�h�a�5�CJOJQJ^JaJmH	sH	
h#W�^Jh+Vh)M�h2G�h�x�h{R�h�aIST�T�T�T�T�T�T�T�T�T�T�T�T'U(U.U/U0U1U3U4U�U�U�U�U�U�U�U�U"V#V(V)V*V+V-V.V�V�V�V�V�V�V�V�VWW�W�W�W�W�W������ĺİĞĞĺĞĞĞĺĞĞĞĺĞĞĞĺĞĔĞĞ�ĞhbB*^Jphh>�B*^Jph"jh*�h2G�B*U^Jphh2G�B*^JphhyL7B*^Jphh*�h2G�B*^Jphh�x�B*^Jphh
2�B*^Jph
h�aI^J
h2G�^J
hu �^Jh�2'h2G�^J3�T�T�W�WzXXY�Y;�<�=�>�?�@�A�B�C�D�E�F�������������������$�d�d[$\$a$gdZ$dh�d�d[$\$a$gd�}�$�d�d[$\$a$gd�%�gd{R�
$1$7$8$H$a$gdT}B
$dha$gd�}�$a$gd#W�$7$8$H$a$gd#W��W�W�W�W�W�W�W�W�W�W�W�W�W�W�W�W�W�WNXOXpXqXsXtXyXzX{X|X�X�X��������ľľľ��ľĸ�����}fR&h)M�5�B*CJOJQJ^JaJph,h}\h}\5�B*CJOJQJ^JaJph.hT}B5�B*CJOJQJ^JaJmH	phsH	&h{R�5�B*CJOJQJ^JaJphhT}Bh�%�^J
h)M�^J
h�&.^J
h�}�^Jh�qh�}�^Jh
2�B*^Jphh�NpB*^Jphhu �B*^Jphh2G�B*^Jphh�;�B*^Jph�X�X�X�X�XAYLYNYOYPYQYWYXYZY\YjYkY�Y�Y�Y�Y�ѿ����z�z�d`\RH>R>4h�%�^JmH	sH	h+C�^JmH	sH	hC]^JmH	sH	h��^JmH	sH	h�%�hT}B+h{R�hZ5�CJOJQJ^JaJmH	sH	%h)M�5�CJOJQJ^JaJmH	sH	h{R�5�CJOJQJ^JaJh)M�5�CJOJQJ^JaJ'h}\h}\0J 5�CJOJQJ^JaJ#h}\h}\5�CJOJQJ^JaJ,h}\h}\5�B*CJOJQJ^JaJph.h)M�5�B*CJOJQJ^JaJmH	phsH	�Y�Y�Y�Y�Y�Y�Y�Y�Y��1�3�:�;�C�K�L�j�k�m�o�����Ȑʐ͐Ր֐ؐߐI�q�r����������������������������������⿻�����������������{�w���s�s�s�sh�&.h#W�h�aGh2G�^JmH	sH	h��h2G�h�Sh�8�h�ywh�3'j�r}T
h�RUVh�Rjh�RUh=�hZh�aIh+C�^JmH	sH	Uh�11^JmH	sH	h��^JmH	sH	h�B�^JmH	sH	h%�^JmH	sH	h+C�^JmH	sH	-Canadian Medical Association Journal 2001: 165 (7):917-928
















 EMBED ChemDraw.Document.6.0  

Figure 1: Chemical structures of some of these synthetic cathinones (a-c) and tryptamines (d, e and f)


Table 1 Identification criteria and sensitivity data for a series of synthetic cathionones and tryptamines using an alkaline liquid extraction and GC-MS.
Compound/ DrugLimit of detection (ng/mL)Retention timeMain Mass spectrometry fragmentsMephedrone501.9058, 91, 119 , 162Methylone502.6858, 91,121, 149Ethylone502.8572, 121, 149, 44, 243Buphedrone501.7372, 44, 105, 148Methcathionone251.5158, 81, 148Dipropyltryptamine253.72114, 144, 169,86,43,1255-ME-MiPT (5-methoxy-alpha-methyltryptamine)253.48161, 117, 89, 44, 204,1445-Methoxy-dipropylatyrptamine253.9486, 117, 160, 246, 215, 44











The use of synthetic cathinones and tryptamines in a psychiatric population 

 PAGE   \* MERGEFORMAT 11




F�G�H�I�J�K�n�o�֐אؐr�������̑���������������$dh$Ifa$gd�}�$�d�d[$\$a$gdZ̑͑ؑۑ��WHHHH$dh$Ifa$gd�}��kd�2$$IfT�l��\��\
F"�$�
���

t��0�������6����������������������4�4�
la�yt�&.�T�������WHHHH$dh$Ifa$gd�}��kd�3$$IfT�l��\��\
F"�$�
���

t��0�������6����������������������4�4�
la�yt�&.�T���"�'�=�WHHHH$dh$Ifa$gd�}��kdT4$$IfT�l��\��\
F"�$�
���

t��0�������6����������������������4�4�
la�yt�&.�T=�>�I�L�Q�b�WHHHH$dh$Ifa$gd�}��kd5$$IfT�l��\��\
F"�$�
���

t��0�������6����������������������4�4�
la�yt�&.�Tb�c�r�u�z���WHHHH$dh$Ifa$gd�}��kd�5$$IfT�l��\��\
F"�$�
���

t��0�������6����������������������4�4�
la�yt�&.�T������������WHHHH$dh$Ifa$gd�}��kd�6$$IfT�l��\��\
F"�$�
���

t��0�������6����������������������4�4�
la�yt�&.�T�������
�WHHHH$dh$Ifa$gd�}��kdt7$$IfT�l��\��\
F"�$�
���

t��0�������6����������������������4�4�
la�yt�&.�T
��)�,�1�L�WHHHH$dh$Ifa$gd�}��kd<8$$IfT�l��\��\
F"�$�
���

t��0�������6����������������������4�4�
la�yt�&.�TL�M�N�O�P�Q�S�T�WLLLLGEgd2G�
$dha$gd�}��kd9$$IfT�l��\��\
F"�$�
���

t��0�������6����������������������4�4�
la�yt�&.�T�Q�R�T�U�W�X�Z�[�]���������ÓēƓǓʓ˓̓�������������������h�1TmHnHujh��Uh��hh��h�qh��5�\�^Jh�q@jh�q@Uh2G�T�V�W�Y�Z�\�]�����ȓɓʓ˓̓�������������
$dha$gd�}�$a$$a$gd�T�gd2G�
21�h:p2G���/ ��=!��"��#��$��%��`�����2Dd
�%'���0�
�
#�A���"�@2��$����0(pkxr�2D~@=�2��$����0(pkxr����]�a�1�x�}	�N���3�cf�`̌}{È4Jal��+˘&&�4���`0v�I��T�7��M�ҢPJ�7%%K��P*���}�s���|-���>�s�������{\��T
Tto�σR@�A�:	m
�zv��"'B�p�&?�Z{��cQT"��K�z�@>�kj��6� #v�V�QD]�Aԭ��1�O���<v>1-�Χ@'���c���7�p~���"&�N{�Zb�L+2Mx����hol˴@G��R���s�e������u�D73��L��
�D}�pdD!iEt���w-��f����(<�>��F�1�Zq�T ]��
I[�٣�kQ$�=�Y�T�F��G��S1�"�l'1V�����N�$���J�P.P�:�̡��=ȫ���n$���(�1�=��~/N,�'Z~'|����[����W�7��U���@�#�.�gE]���iB�r�F�W~��*&�u��z��13;�}�E~F�3��y-G�x�8�3hS@�z,/�r'��#� ��$y�=��AA�@�7tbC'ʞWeࡉ�2e��>�ii�_�����~|<����`Ι�k:��)Dz�ڱl����?t9(�v�����g��2?3s�m�m'�j��vF�F�=��<�$�z���~6�;m�׭D�7����s�a�����vh+����@Z�+�$$��:�}�BZ��!���OO0��v��aN�Y+�����%kN´k/Y�<�_	j
b��Is�^)P�?G=oXO��s�}r�L=*Q7"7F���1?�:�?d��7��v�m$��}���(�߸r�0��.+��r<!c>�36c?����׼oDj\݂�ƶ�ҝ�ǜĘ�D����p�����+��3���Հ)1�*c��p���z��Ӟ�M��y78���#�� b|$ji䑨���+��?NbL�$�����R1^���㸌v��?���7�vX��X1�r,SA� b<#���Q��Xc�X42����(��ב .��1�ܝ��0��~Pi��0�
���@u@Ę���>�5�_]2�Q�b0%����Q�Qwv7nj�3�i_l������^�1�y䟿혵����k@����Q�u[<���W��һ�1���s�
�g�B��0�����܆�ƶ������tw�CƳ��7?���W��|���f�J���O�:T~|��@�֑Tr��
�-����;Ə�q(�xL|����u�x|����_�;�.��~��׼}���k�=c��oc��}��/���A��=�G�Ϗ5��Nz~L��@kA:V�ϣ��w�e^=2�$�g�c��k��7�M�cEӘ�ަ1�{פ��1�I����\W0V��1}�`�=�����_c�M
�I��bhT)���W��^�yr&��;ӝh�s]Q����n�x���f�Yo8*V�q��A7���|���b�^W8m�F�9y�ǡ�
�����#�~�k��bE:0����J�s����D�a��>�`|pe<�ڭD����������3s-+�?���e��8�y��r�%�LUA�W��^��V�;~��Q�'�)��([��2dy��x��f=?޺��V���p�"�4|��S�N���I��Wx�aB�s�i_;�B�/=�Y��)�W���U��y���@1j��o�N��a,�7�><�v�f����#@zNU��~�r@�s/,m??Ӷ�+�7��D}�>����Tىlg�'����׻��.�-�w3�{�Zi�k6���7/$�0�{��Ƚu���Ɩ����;f�1�{���*����:�=z�]���Ņ[�t�I��I���#�v��?�0�W�pľz_E�
�)[cr'a���op���qb콧���crɸ�}5�/�q;p��L<Tn~�(׽�4�e[�;�$�oU��XQ��+��f�Oq0q0~�u�f���j>�Q늋���c��$��+4��NZWd[�+��X���wL����n}�XA>�_�v��=�m�B�q�M�'p��M�/cF��1cEk`K?�RӇ�7x�u��5�\_8)Vp]A�����'�+��iҹ��X�uE;�q/���	?��X���N�c^���
c�������[	��f��I�_�v�x��b��
��;��_���H�$��;s�#�|N��`�B�+]���3�Um�[#_k�?�����!�>����c�v+l6�j�m�c���)������\�|��~F��}Ny&�w��c^��3!>��u�m�6�_v����e�-l��*�_���xE���j�c��v|kU�1�x�˜�A4�|ҳ��3�q.sA�z��7]'�>�.��nC���T82������g�R��&������_H��|!���6#�٩��H��R���u���&�CT�!����q��L$"Mqh��+����ű�")�"ޝZ��zM5�Z���)�~
�U�N�q���*��
���M�,���
_�/Y���Qsd�����̜}��`��G~��z���NI,Qgc�C��>�7�r��=������m�oJ��G(�9��&��)���D/��븬ߩ�`���T��꧀�����6.�=E��ǚ�@���l>��J�i�,��A\��ƅ2��1�Ȏ5�!�#֧+�<��x4v(���}c�x��Z��f��)�B�2�uJ2�c@�*t���o�m���>��>���o���`YK��_�H�s�#�ɱ�W���8�"Z�s�mg���|'35(������P��2=���4:58�oWY�D~���ߗ��ˎ7��E8�Ƀ�Q��U��l�*;��fA����ϊ�-���U��&�����z�um�Tvj�)��Nd���D�?j`X���ā�|���WUy�%�<̱��Ѿ� �~�q��ު�D����u�7n�l}��;�y/k�9��[a��z�
�Nm;e�e��l�<m��ç���.ǰ��G���^�� +��o�׼��[c�:j��`��~�1���|Py�c���K���x�w�~��ر���ؒ?��G�¸�=j�0&���mRY���-�aM-�$iU���#^8n:���W��$����6��o�&1&wƆ�82�t`��B����27m^K�e����]��gA:/�9 �������a�-��w�25�N�x��xxW�Y��%�8�
c}�{~MK��οs�ۨ0�5Oc�kޗ���Ώ'̚f���}3u�k��_:�p�(���������c'4��6?�ؾr�4뻹�:��m��8MaL|&��Xq���V���ͭmF9�d0�5oxg�񧍿����}�XcK�{b�{�<p}B|�6r�=���C�ޓ~�4��)?���xg�;b݈��C���}+U�����)
�%t��X��%w�cƊ�XA|��w_��Ұ�� ����w�9f]����f�T��_�e���Y�{&���1ce���1��o��1V�xLNiX9�m�c����i
c�+4��׭׼m2�����81b0xu+R^�%�}�B�+�:�)τ�1�A�ǡ�
7ރ�-�~~�k��0NQ~��㤄-I-]w/����5�S0�~�1�nڏ�>�L��q��ko�I���EOִ�ll�Y�����ur�Կ�_�\��!�� �8M��oN���~�{A���)�O��W@'�_��$jzA�^��=b�PV:U?l��	

 !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUV����XYZ[\]^����a�����#����fghijklmnopqrstuvwxyz{|}~�Root Entry��������	�Fp����c�Data
������������W�9WordDocument
��������4�ObjectPool
���������p����_1417507517��������!m�A.���� �������������Ole
������������EPRINT����e�CompObj������������~������������	
����
 !"#$%&'()*+����-����������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������
����!m�A.���� ���CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.6.0�9�q
����Oh��+'��0������	4@
`lx
������8The use of designer drugs in the psychiatric pop������������������������������������������������������������������������������������������������������������������������$������������l��08AD EMF�`�8�S�F, EMF+@��``FD8EMF+@"@@!@0@�?0@
�#>2@CC�{E؃E@��4@@0$��UUiBARIAL@H<��h��?@�, �}qD���DO!bRp�����Arial(�x?	�>	�I>	��"�|	8�����9�����N�/�D����N�/�D�؋�N��DD�"�|x��-DT�!	@\��0�w ����|�����w�P�w��8ެ^��N8!�T=	��9$�dv%TT�����A�A��L��������PO%
�Fl`EMF+@0$��UUiBARIAL@�, ��E>D���CN%TTyNY�A�AyWL��������PN%
�Fl`EMF+@0$��UUiBARIAL@�, �6N�D`�CO%TT B&M�A�A KL��������PO%
�Fl`EMF+@0$��UUiBARIAL@�, �6N�D�IDO%TT �&��A�A �L��������PO%
�Fl`EMF+@<0��V�@@���
@ ҭvD��[D>�CDe>D:$$�=�=_888 %%�W$yv���	���%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ >�CDe>D�bD��[D:$$�=�=_888 %%�W$Yv������%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �bD��[D'z�Ce>D:$$�=�=_888 %%�W$8v_�����%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ 'z�Ce>D�](C��[D:$$�=�=_888 %%�W$v?�����%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �8zD��YD�8zD��D:$$�=�=_888 %%�W$�����	��	�
%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �"sD��YD�"sD��D:$$�=�=_888 %%�W$�����	��	�
%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ L<D�(�C��D;>�C:$$�=�=_888 %%�W$[:{T���%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ ��D;>�C�&D��!C:$$�=�=_888 %%�W$[mA����%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �&D��!C�aD��!C:$$�=�=_888 %%�W$f�����%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �aD��!C�OsD;>�C:$$�=�=_888 %%�W$��A���	�%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ 	�JDqj�C�OsD;>�C:$$�=�=_888 %%�W$~:�T�	�%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ >�CDe>D>�CD��D:$$�=�=_888 %%�W$yV�}����%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ ���D��CJ��D�� D:$$�=�=_888 %%�W$#I=jm��h%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ J��D�� Dz�D29JD:$$�=�=_888 %%�W$#c=��hi%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ Y�D�-NDJ�De>D:$$�=�=_888 %%�W$�v"��8��%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ J�De>DJ�D�UD:$$�=�=_888 %%�W$�P}���9%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ u:�D�B�CJ�D�UD:$$�=�=_888 %%�W$�F"W���9%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ ~|�D���C��D�UD:$$�=�=_888 %%�W$�=�W�
�9%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ ��D�UD��De>D:$$�=�=_888 %%�W$�P�}�9��%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �t�DkmD�t�D�M:D:$$�=�=_888 %%�W$�S�z+c+l%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ ��De>D~|�D��[D:$$�=�=_888 %%�W$�v�����
�%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ ~|�D��[DJ�De>D:$$�=�=_888 %%�W$�v��
���%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ ~|�D��SD#��D�M:D:$$�=�=_888 %%�W$�s���
q�l%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ ~|�D���CJ�D�UD:$$�=�=_888 %%�W$�=W�
�9%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ ~|�D���C#��DkmD:$$�=�=_888 %%�W$�C�Z�
_�c%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ ҭvD��[D��De>D:$$�=�=_888 %%�W$�v���	���%�%�$$�A�A(:
Fl`EMF+@0$��UUiBARIAL@�, �DdEEd�xDO%TT�����A�A��L��������PO%
�Fl`EMF+@0$��UUiBARIAL@�, �P�uEO�7DO%TTut{�A�Au}L��������PO%
�Fl`EMF+@0$��UUiBARIAL@�, �P�uE
�CO%TTu<{G�A�AuEL��������PO%
�Fl`EMF+@0$��UUiBARIAL@�, ��-E�
BDN%TT�{���A�A��L��������PN%
�Fl`EMF+@0$��UUiBARIAL@�, ��-E2NDH%TT�����A�A��L��������PH%
�Fl`EMF+@<0��V�@@���
@ ��FE��ID.;E�b.D:$$�=�=_888 %%�W$�l��	��%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ .;E�b.D.;E���C:$$�=�=_888 %%�W$�I�r����%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ ��GE��GD��GES/xD:$$�=�=_888 %%�W$�|�����	%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ z�EE��GDz�EES/xD:$$�=�=_888 %%�W$�|������	%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �RE�b.Dqd^E��ID:$$�=�=_888 %%�W$l<��!��#	%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ D<TE�*Dqd^E�BD:$$�=�=_888 %%�W$i<�!��#�%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ qd^E��ID�.jE�b.D:$$�=�=_888 %%�W$6lZ��#	q%�%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �.jE�b.D�.jE���C:$$�=�=_888 %%�W$TIZrq%�q%�%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ ��hE�*D��hEvf�C:$$�=�=_888 %%�W$PKVp.%�.%�%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �.jE���Cqd^E.e�C:$$�=�=_888 %%�W$68ZPq%��#�%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ qd^E.e�C�RE���C:$$�=�=_888 %%�W$8<P�#��!�%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ qd^E�|�CD<TEuf�C:$$�=�=_888 %%�W$<<R�#��!�%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �RE�b.D�RE���C:$$�=�=_888 %%�W$Ir�!��!�%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ L"E(DALxE��8D:$$�=�=_888 %%�W$xZ�y�(��']%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ L"E(D�dxE��C:$$�=�=_888 %%�W$xC�a�(��'_%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �.jE�b.D�;uEm�<D:$$�=�=_888 %%�W$Tlw|q%�5'�%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �.jE���Cp,uE,I�C:$$�=�=_888 %%�W$T@wPq%�3'2%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ ��FE��ID�RE�b.D:$$�=�=_888 %%�W$�l��	�!�%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ hU-E�<EDWp#E�b.D:$$�=�=_888 %%�W$�l�����%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ .;E�b.D1E�ZED:$$�=�=_888 %%�W$�l����M�%�%�$$�A�A(:
FpdEMF+@0$���BARIAL@�0$��p E�-�Db) (Rp��Arialh�x?	�>	�I>	4�"�|	8 ���P�98����N�_DD��_D\�؋�N�?D��������|`�|����]�|���|
��|7
��Z$ @�w �@����wt����|��|����
��|��w�Z$8!����+�w @�w7
�dv%T`�����A�A��L��������Tb) 	%
�F|pEMF+@0$���BARIAL@�<0�	��'E�-�DMethylone%T������A�A��	L��������`Methylone
					%
�Fl`EMF+@0$��UUiBARIAL@�, �77IE��EO(Rp�����Arial(�x?	�>	�I>	��"�|	8 �����9�����N�/�D��/�D�؋�N��DD�x�xl��|`�|����]�|���|
��|7
��Z$ @�w���H��w4����|��|����
��|��w�Z$8!����+�w @�w7
�dv%TTe	p�A�AnL��������PO%
�Fl`EMF+@0$��UUiBARIAL@�, ���1E4�DN%TT�B�M�A�A�KL��������PN%
�Fl`EMF+@0$��UUiBARIAL@�, ���1E�#EH%TT�J�U�A�A�SL��������PH%
�Fl`EMF+@0$��UUiBARIAL@�, ���yE��DO%TT�
�A�AL��������PO%
�Fl`EMF+@0$��UUiBARIAL@�, ���yE���DO%TT;�F�A�ADL��������PO%
�Fl`EMF+@<0��V�@@���
@ ��JEr��Dt�>E�J�D:$$�=�=_888 %%�W$�2
Kd s~[%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ t�>E�J�Dt�>E���D:$$�=�=_888 %%�W$��9~[~)%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �tKE{
�D�tKE��E:$$�=�=_888 %%�W$Ci� `� S%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ "�IE{
�D"�IE��E:$$�=�=_888 %%�W$CiC `C S%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ D'E�J�D+.Er��D:$$�=�=_888 %%�W$�2�K�[�s%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ 1E�DD'E�J�D:$$�=�=_888 %%�W$�2�HKF�[%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ t�>E�J�D��4E�D:$$�=�=_888 %%�W$�2�H~[�H%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ v�|EM��D:��E���D:$$�=�=_888 %%�W$�	�'`(�v)B%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ :��E���D�k|E�D:$$�=�=_888 %%�W$�!�@v)B\(�%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ 3[yE%��D�9nE�J�D:$$�=�=_888 %%�W$^2�B�'�&[%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �9nE�J�D�9nE���D:$$�=�=_888 %%�W$^e9&[&)%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �KyE��D�9nE���D:$$�=�=_888 %%�W$^��'�&)%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �\bEr��D�VE�J�D:$$�=�=_888 %%�W$!2FK0$sJ"[%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �VE�J�D�VE���D:$$�=�=_888 %%�W$!(9J"[J")%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ z$XE�d�Dz$XE���D:$$�=�=_888 %%�W$&,7�"4�"P%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �VE���D�\bE�1�D:$$�=�=_888 %%�W$!�FJ")0$%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �\bE�1�D�9nE���D:$$�=�=_888 %%�W$@�e0$&)%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �\bE���D�lE���D:$$�=�=_888 %%�W$@a0$_�%P%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �\bEr��D�9nE�J�D:$$�=�=_888 %%�W$@2eK0$s&[%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �\bE�1�D�lE�d�D:$$�=�=_888 %%�W$@0aF0$%�%4%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ ��JEr��D�VE�J�D:$$�=�=_888 %%�W$2(Kd sJ"[%�%�$$�A�A(:
FpdEMF+@0$���BARIAL@�0$���E��'Ec) (Rp��Arialh�x?	�>	�I>	4�"�|	8 ���P�98����N�_DD��_D\�؋�N�?D��������|`�|����]�|���|
��|7
��Z$ @�w �@����wt����|��|����
��|��w�Z$8!����+�w @�w7
�dv%T`�����A�A��L��������Tc) %
�FxlEMF+@0$���BARIAL@�8,���!E��'EEthylone%T|�����A�A��L��������\Ethylone				%
�FpdEMF+@0$���BARIAL@�0$��EC�ՙDa) %T`�0��A�A�L��������Ta) 	%
�FpdEMF+@0$���BARIAL@�0$����C�ՙDMDPV%Td2�`��A�A2�L��������TMDPV
%
�Fl`EMF+@0$��UUiBARIAL@�, �o
�DI
EN(Rp�����Arial(�x?	�>	�I>	��"�|	8 �����������N��D���D�؋�N�߸DD�x�xl��|`�|����]�|���|
��|7
��Z$ @�w���H��w4����|��|����
��|��w�Z$8!����+�w @�w7
�dv%TT�`�k�A�A�iL��������PN%
�Fl`EMF+@0$��UUiBARIAL@�, ��w�D�(�DH%TT�����A�A��L��������PH%
�Fl`EMF+@0$��UUiBARIAL@�, ��w�Dn<�DN%TT�����A�A��L��������PN%
�Fl`EMF+@0$��UUiBARIAL@�, ��c�C��DO%TT6<(�A�A6&L��������PO%
�Fl`EMF+@<0��V�@@���
@ qX�D,�	E�>�D��D:$$�=�=_888 %%�W$�A�d�&G%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �>�D��D"��Dg,�D:$$�=�=_888 %%�W$�:�H&G�%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ "��Dg,�D�DB4�D:$$�=�=_888 %%�W$��A�W�%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �DB4�D�%�D�D:$$�=�=_888 %%�W$���W���%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �،D&Z�D��D�D:$$�=�=_888 %%�W$���=pL�%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �%�D�D�D�ٵD:$$�=�=_888 %%�W$�������%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ z$�D�N�D�AhD�u�D:$$�=�=_888 %%�W$����QC	�%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �AhD�u�DA�8D�άD:$$�=�=_888 %%�W$s���C	�^�
%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �aD-Z�DA�8DV��D:$$�=�=_888 %%�W$s���	
^%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ A�8D�άD��	D�u�D:$$�=�=_888 %%�W$T�y�^�
z�%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ ��	D�u�D��	D%��D:$$�=�=_888 %%�W$T�[z�z%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ j8D-Z�Dj8D���D:$$�=�=_888 %%�W$X�_�
��%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ ��	D%��DA�8DGk�D:$$�=�=_888 %%�W$Ty&z^*%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ A�8DGk�D�AhD%��D:$$�=�=_888 %%�W$s�&^*C	%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ A�8D���D�aD���D:$$�=�=_888 %%�W$s�!^�	�%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �DB4�D�AhD%��D:$$�=�=_888 %%�W$��W�C	%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �AhD�u�D�AhD%��D:$$�=�=_888 %%�W$���C	�C	%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ ���C�c�D�N,C%��D:$$�=�=_888 %%�W$8#N�%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ ��	D%��D�*�CQ{�D:$$�=�=_888 %%�W$:[#z�%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ Hd�D��Ee��D��E:$$�=�=_888 %%�W$j�����%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ Hd�D��E���D=�E:$$�=�=_888 %%�W$P*p��l0%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ 5\�DMEHd�D��E:$$�=�=_888 %%�W$�cpk��%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ \i�DXEس�D�7E:$$�=�=_888 %%�W$�u��]
�:�%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ \i�DXEyٯDj
#E:$$�=�=_888 %%�W$�|��]
�
%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ %o�D��
E\i�DXE:$$�=�=_888 %%�W$�g����]
�%�%�$$�A�A(:
FpdEMF+@0$���BARIAL@�0$���"CW�)Ed) (Rp��Arialh�x?	�>	�I>	4�"�|	8 ���P�98����N�_DD��_D\�؋�N�?D��������|`�|����]�|���|
��|7
��Z$ @�w �@����wt����|��|����
��|��w�Z$8!����+�w @�w7
�dv%T`�+��A�A�L��������Td) 	%
�F��EMF+@0$���BARIAL@�h\���CW�)E5-Methoxy-diisopropyltryptamine%T,���A�A,�L���������5-Methoxy-diisopropyltryptamine	
										
		%
�Fl`EMF+@0$��UUiBARIAL@�, ��s�D�rEN(Rp�����Arial(�x?	�>	�I>	��"�|	8 �����������N��D���D�؋�N�߸DD�x�xl��|`�|����]�|���|
��|7
��Z$ @�w���H��w4����|��|����
��|��w�Z$8!����+�w @�w7
�dv%TT�m�x�A�A�vL��������PN%
�Fl`EMF+@0$��UUiBARIAL@�, �
@Dg�9EH%TTz����A�Az�L��������PH%
�Fl`EMF+@0$��UUiBARIAL@�, �
@D.�<EN%TTz����A�Az�L��������PN%
�Fl`EMF+@<0��V�@@���
@ ���D��rE2�D�gE:$$�=�=_888 %%�W$�L�px�&�
�$%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ 2�D�gETWD3dE:$$�=�=_888 %%�W$�D�R�
�$�t$%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ TWD3dE�\EDg0VE:$$�=�=_888 %%�W$z!�K�t$�>"%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �\EDg0VE�gD nJE:$$�=�=_888 %%�W$z�'�>";	\ %�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ ��BD�#TEm�^D nJE:$$�=�=_888 %%�W$y�"��!�\ %�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �gD nJE��JD�@E:$$�=�=_888 %%�W$~��	;	\ �%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �s=DXP?E�D�)CE:$$�=�=_888 %%�W$W�|����2%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �D�)CE�o�C7�;E:$$�=�=_888 %%�W$7�^��2�	%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ Dw+DE�o�C��=E:$$�=�=_888 %%�W$7�Y�`\�[%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �o�C7�;ELy%C�)CE:$$�=�=_888 %%�W$�>��	�2%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ Ly%C�)CELy%C��QE:$$�=�=_888 %%�W$��2��!%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ paACw+DEpaACɰPE:$$�=�=_888 %%�W$�"�\�\!%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ Ly%C��QE�o�C	�XE:$$�=�=_888 %%�W$>.��!��"%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �o�C	�XE�D��QE:$$�=�=_888 %%�W$7^.��"��!%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �o�Cs�VEDɰPE:$$�=�=_888 %%�W$7Y)�]"`\!%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �\EDg0VE�D��QE:$$�=�=_888 %%�W$W�'�>"��!%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �D�)CE�D��QE:$$�=�=_888 %%�W$W�^�2��!%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ 9ՍDj�vE�B{DɨE:$$�=�=_888 %%�W$�t��Qp'
�(%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ J”D�?uE
��D;�wE:$$�=�=_888 %%�W$�p�}�6'�
�'%�%�$$�A�A(:
FpdEMF+@0$���BARIAL@�0$��)C0��Ee) (Rp��Arialh�x?	�>	�I>	4�"�|	8 ���P�98����N�_DD��_D\�؋�N�?D��������|`�|����]�|���|
��|7
��Z$ @�w �@����wt����|��|����
��|��w�Z$8!����+�w @�w7
�dv%T`�*��A�A�L��������Te) 	%
�F��EMF+@0$���BARIAL@�L@���C0��EDimethyltryptamine%T�+����A�A+�L��������pDimethyltryptamine
				
		%
�Fl`EMF+@0$��UUiBARIAL@�, �?�OE�hEN(Rp�����Arial(�x?	�>	�I>	��"�|	8 �����������N��D���D�؋�N�߸DD�x�xl��|`�|����]�|���|
��|7
��Z$ @�w���H��w4����|��|����
��|��w�Z$8!����+�w @�w7
�dv%TTS^�A�A\L��������PN%
�Fl`EMF+@0$��UUiBARIAL@�, �,�:EpX5EH%TT�����A�A��L��������PH%
�Fl`EMF+@0$��UUiBARIAL@�, �,�:E7b8EN%TT�����A�A��L��������PN%
�Fl`EMF+@<0��V�@@���
@ �8PE��hE��LEy^E:$$�=�=_888 %%�W$	6WI!8%� �#%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ ��LEy^E�@ER�[E:$$�=�=_888 %%�W$�/<� �#�"#%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �@ER�[E�<E�]OE:$$�=�=_888 %%�W$��5�"#&!%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �<E�]OE#�CE`�DE:$$�=�=_888 %%�W$���&!Jv%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �|;E)�ME4�AE`�DE:$$�=�=_888 %%�W$����� �v%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ #�CE`�DE�y=E�0<E:$$�=�=_888 %%�W$����JvI%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �:Ea�:Ed�/E�M>E:$$�=�=_888 %%�W$������k%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ d�/E�M>E�f$E��7E:$$�=�=_888 %%�W$����kF`%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �.E-5?E�f$E��9E:$$�=�=_888 %%�W$������F�%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �f$E��7E�E�M>E:$$�=�=_888 %%�W$����F`xk%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �E�M>E�E�VKE:$$�=�=_888 %%�W$���xkx� %�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ ^�E-5?E^�E�oJE:$$�=�=_888 %%�W$���	���\ %�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �E�VKE�f$E#�QE:$$�=�=_888 %%�W$��x� F�!%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �f$E#�QEd�/E�VKE:$$�=�=_888 %%�W$��F�!� %�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �f$E�PE�.E�oJE:$$�=�=_888 %%�W$��FB!�\ %�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ �<E�]OEd�/E�VKE:$$�=�=_888 %%�W$��&!� %�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ d�/E�M>Ed�/E�VKE:$$�=�=_888 %%�W$���k� %�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ £]EE�mE�aE��yE:$$�=�=_888 %%�W$4\E�o#�%$�'%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ £]EE�mE|\fE��cE:$$�=�=_888 %%�W$4DQco#�%�$o$%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ ��RE�BkE£]EE�mE:$$�=�=_888 %%�W$V:c�!�%o#�%%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ 0+HE7�tEWk;Ew�qE:$$�=�=_888 %%�W$�gu�'��&%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ 0+HE7�tEM2LE�y�E:$$�=�=_888 %%�W$�n��'� )%�%�$$�A�A(:
Fl`EMF+@<0��V�@@���
@ DOER�lE0+HE7�tE:$$�=�=_888 %%�W$�Zu"!�%�'%�%�$$�A�A(:
FpdEMF+@0$���BARIAL@�0$��+E�)�Ef) (Rp��Arialh�x?	�>	�I>	4�"�|	8 ���P�98����N�_DD��_D\�؋�N�?D��������|`�|����]�|���|
��|7
��Z$ @�w �@����wt����|��|����
��|��w�Z$8!����+�w @�w7
�dv%T`�����A�A��L��������Tf) %
�F��EMF+@0$���BARIAL@�TH���#E�)�EDiisopropyltryptamine%T���=��A�A��L��������xDiisopropyltryptamine						
		%
�F..EMF+@CDIFVjCD0100�ChemDraw 13.0.0.3015�N	6M�	����	@�@'
:;E<J
BCD
`��	���ft����xx#()*+(,
-.$$$$2������������������������$�Arial�Times New RomanxXX$����d�g(�XX$d'�`��Chemical Formula: �Exact Mass: �Molecular Weight: �m/z: �Elemental Analysis: �Boiling Point: �Melting Point: �Critical Temp: �Critical Pres: �Critical Vol: �Gibbs Energy: �	Log P: �MR: �Henry's Law: �Heat of Form: �tPSA: �	CLogP: �CMR: �LogS: �pKa: ��$$�^���D�
��U�i�gv
���c[��]
��U�iNE
�7��c[(�,
�7�U�i<4
�7����gv
�+H7�!��P�sP�s����!y#
`�O�	�
?��]
�+H� �A�T[��;�T[ �A�b`#
`�N�
�`.��F
�7��je�O
�7��j�l
�7�
�`.1�t
�7��G6��
�+H7��9K�T3K�!9H��#
`�O�!7M\��
�7�T&d��
�+H7���fK���`K���fH��#
`�O��c[��
���
?��
����0���
�7��
?��
�7��c[��
��U�i���
�7�
�
�
�
�
�
�
�
�
��
�	

�
�

�
�
�
�

� 
	

�!
	
�"

�#

�$

�%

�&

�'

�(
',)�)
	
�*

)$%�+
'%&�,

�/,��9��}\J�
�.��`��}

�0��S/g
�1��9/g
7�2m�z��}
+H7��}�zӰw�z��}&q�#
`�O�3��S�Z�
�4��`I��
7�5��S���
�6��9���
�7�~,I��
7�8��9�Z�
7�9��Ft��
7�:x�[~�
+H7��^q��ގXq����^�7�#
`�O�;�|1~�
+H7�R64q��C.q���O4�7�#
`�O�<��`�pP
+H7��cj�MǪ]j�MqUi��R#`�NH�=��Ss�9
7�>
.0
�?
01
�@
.2�A
 34FKB�B
!45
�C
"56BIJD�D
#67
�E
$78DF�F
%38
�G
&9:
�H
'9;
�I
(5:
�J@CDIF
)6;
�K
*.3
�L
+<=
�M
,0<
�T߽�b�)��6M�
/�S��"�
.�Ut���Gn
0�V$L��Gn
17�Wm
"�
2+H7���U����U����ȇ#
`�O�X����W
3+H7��y�J�T`��J�T
O�jZ#`�NH�Yt��x�@
47�Z��?�)
57�[n+��h�
6+H7���������������)"�#
`�O�\�r�N��
77�]*���h�
8+H7��s����������]��)"�#
`�O�^t���d�
9�_$L��d�
:�`�����
;7�at��[֛
<�b$L�[֛
=7�c{%����
>7�d
?SU
�e
@UV
�f
ASW�g
BYZ
�h
CXY
�i
DUX
�j
E[\
�k
F\]
�l
G]^
�m
H^_
�n
I[_
�o
J`a
�p
Kabtoq�q
Lbc
�r
Mc_qmn�s
N`^olm�t
OSa
�y���t�|%9a��
S�x��`A�
R+H�%Z���Є	���%Zɴ#
`�N�zT���'�
T7�{?����
U7�|�P��i�
V�}��^җ
W7�~���i�
X+H7�˧�������i����#`�NH����{o
Y��0��X
Z7�����B
[7��.7��B
\���R��X
]7��.7��{o
^���R��`+
_+H7��Q�(��Q�(�%��.#
`�O��.7�Q�
`7���d��
a���+��
b7��ǘ��o�
c7��� ��
d��P�
�
e7���	9�Ш
f7��
gxz
��
hz{
��
i{|
��
j|}�����
k}~
��
l~
��
m������
n��
��
o�������
p��
��
q�������
r|�
��
s�
��
t��
��
u��
��
v��
��
w��
��
xx�
��
y��
��
z��
��
{x�
���%e����䥦
~��� �6G�
}+H�!��������!���΍#
`�N�������
7���ȵ�[g
�7��7>�ܻ^
���{��#o
�7���nܻ^
�+H7��ju5\�%eu5\X�p�Ca#`�NH��i�v`1D
���V�h^,
�7��i�v[�
�7�����[�
�7�����^,
�7�����`1D
������ؚx
�7�����=��
�7��
���
��
���@�
�
CDIF
��
���
��
��������
���
��
���
��
��������
���
��
�������
���
��
��������
���
��
���
��
���
��
���
����\m�%�t�ڍ�
��������
�+H����Z��.׿Z�����z��#
`�N���%�V�
�7����o�p
�7���$��i
�����yb�w
�7��Цe�i
�+H7��bJ�f��\J�fi`hj�k#`�NH���bm�RQ
���C�`i�;
�7���bm'�%
�7��"i�'�%
�7��l�i�;
�7��"i��RQ
����&�V��
������H�
�7��獵,K�
�7�����R�
����W�V�g
�7���X���
�7��
���
��
���
��
���
��
�������
���
��
���
��
�������
���
��
�����
���
�
����
���
�
���
�
���
�
���
�
���
�
���
�
���
�	
���
�O|���V|���4|��Yty
-8Chemical Interpretation is not possible for this label�b) Methylone�v|;MG|{B��(|;PZe
P8Chemical Interpretation is not possible for this label�c) Ethylone�w|{�0|����|{�MYH
Q8Chemical Interpretation is not possible for this label�a) MDPV���P@qFL��S���
|�$d) 5-Methoxy-diisopropyltryptamine.�d) 5-Methoxy-diisopropyltryptamine��(�@M(��(��
��e) Dimethyltryptamine!�e) Dimethyltryptamine�
N�n����/N	sϭ
��f) Diisopropyltryptamine$�f) Diisopropyltryptamine �����

�P@q��xyz{|}~���������������������������������� �����

(�@M�x������������������������������ ��
�

N�n������������������������������	Ld����)��?�?"����FEMF+@ObjInfo	����CONTENTS��������������-1Table����)w:SummaryInformation(�����	

���� !"����%����&'(����*+,-./0123456789:;<=>?@ABCDEF����������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������VjCD0100�ChemDraw 13.0.0.3015�N	6M�	����	@�@'
:;E<J
BCD
`��	���ft����xx#()*+(,
-.$$$$2������������������������$�Arial�Times New RomanxXX$����d�g(�XX$dd'�`��Chemical Formula: �Exact Mass: �Molecular Weight: �m/z: �Elemental Analysis: �Boiling Point: �Melting Point: �Critical Temp: �Critical Pres: �Critical Vol: �Gibbs Energy: �	Log P: �MR: �Henry's Law: �Heat of Form: �tPSA: �	CLogP: �CMR: �LogS: �pKa: ��$$�^���D�
��U�i�gv
���c[��]
��U�iNE
�7��c[(�,
�7�U�i<4
�7����gv
�+H7�!��P�sP�s����!y#
`�O�	�
?��]
�+H� �A�T[��;�T[ �A�b`#
`�N�
�`.��F
�7��je�O
�7��j�l
�7�
�`.1�t
�7��G6��
�+H7��9K�T3K�!9H��#
`�O�!7M\��
�7�T&d��
�+H7���fK���`K���fH��#
`�O��c[��
���
?��
����0���
�7��
?��
�7��c[��
��U�i���
�7�
�
�
�
�
�
�
�
�
��
�	

�
�

�
�
�
�

� 
	

�!
	
�"

�#

�$

�%

�&

�'

�(
',)�)
	
�*

)$%�+
'%&�,

�/,��9��}\J�
�.��`��}

�0��S/g
�1��9/g
7�2m�z��}
+H7��}�zӰw�z��}&q�#
`�O�3��S�Z�
�4��`I��
7�5��S���
�6��9���
�7�~,I��
7�8��9�Z�
7�9��Ft��
7�:x�[~�
+H7��^q��ގXq����^�7�#
`�O�;�|1~�
+H7�R64q��C.q���O4�7�#
`�O�<��`�pP
+H7��cj�MǪ]j�MqUi��R#`�NH�=��Ss�9
7�>
.0
�?
01
�@
.2�A
 34FKB�B
!45
�C
"56BIJD�D
#67
�E
$78DF�F
%38
�G
&9:
�H
'9;
�I
(5:
�J
)6;
�K
*.3
�L
+<=
�M
,0<
�T߽�b�)��6M�
/�S��"�
.�Ut���Gn
0�V$L��Gn
17�Wm
"�
2+H7���U����U����ȇ#
`�O�X����W
3+H7��y�J�T`��J�T
O�jZ#`�NH�Yt��x�@
47�Z��?�)
57�[n+��h�
6+H7���������������)"�#
`�O�\�r�N��
77�]*���h�
8+H7��s����������]��)"�#
`�O�^t���d�
9�_$L��d�
:�`�����
;7�at��[֛
<�b$L�[֛
=7�c{%����
>7�d
?SU
�e
@UV
�f
ASW�g
BYZ
�h
CXY
�i
DUX
�j
E[\
�k
F\]
�l
G]^
�m
H^_
�n
I[_
�o
J`a
�p
Kabtoq�q
Lbc
�r
Mc_qmn�s
N`^olm�t
OSa
�y���t�|%9a��
S�x��`A�
R+H�%Z���Є	���%Zɴ#
`�N�zT���'�
T7�{?����
U7�|�P��i�
V�}��^җ
W7�~���i�
X+H7�˧�������i����#`�NH����{o
Y��0��X
Z7�����B
[7��.7��B
\���R��X
]7��.7��{o
^���R��`+
_+H7��Q�(��Q�(�%��.#
`�O��.7�Q�
`7���d��
a���+��
b7��ǘ��o�
c7��� ��
d��P�
�
e7���	9�Ш
f7��
gxz
��
hz{
��
i{|
��
j|}�����
k}~
��
l~
��
m������
n��
��
o�������
p��
��
q�������
r|�
��
s�
��
t��
��
u��
��
v��
��
w��
��
xx�
��
y��
��
z��
��
{x�
���%e����䥦
~��� �6G�
}+H�!��������!���΍#
`�N�������
7���ȵ�[g
�7��7>�ܻ^
���{��#o
�7���nܻ^
�+H7��ju5\�%eu5\X�p�Ca#`�NH��i�v`1D
���V�h^,
�7��i�v[�
�7�����[�
�7�����^,
�7�����`1D
������ؚx
�7�����=��
�7��
���
��
���
��
���
��
��������
���
��
���
��
��������
���
��
�������
���
��
��������
���
��
���
��
���
��
���
����\m�%�t�ڍ�
��������
�+H����Z��.׿Z�����z��#
`�N���%�V�
�7����o�p
�7���$��i
�����yb�w
�7��Цe�i
�+H7��bJ�f��\J�fi`hj�k#`�NH���bm�RQ
���C�`i�;
�7���bm'�%
�7��"i�'�%
�7��l�i�;
�7��"i��RQ
����&�V��
������H�
�7��獵,K�
�7�����R�
����W�V�g
�7���X���
�7��
���
��
���
��
���
��
�������
���
��
���
��
�������
���
��
�����
���
�
����
���
�
���
�
���
�
���
�
���
�
���
�
���
�	
���
�O|���V|���4|��Yty
-8Chemical Interpretation is not possible for this label�b) Methylone�v|;MG|{B��(|;PZe
P8Chemical Interpretation is not possible for this label�c) Ethylone�w|{�0|����|{�MYH
Q8Chemical Interpretation is not possible for this label�a) MDPV���P@qFL��S���
|�$d) 5-Methoxy-diisopropyltryptamine.�d) 5-Methoxy-diisopropyltryptamine��(�@M(��(��
��e) Dimethyltryptamine!�e) Dimethyltryptamine�
N�n����/N	sϭ
��f) Diisopropyltryptamine$�f) Diisopropyltryptamine �����

�P@q��xyz{|}~���������������������������������� �����

(�@M�x������������������������������ ��
�

N�n������������������������������	�@HG�ܗ���~h��]��we�����PiL(#&�5����i 
K��{ÈKY��B�t��O�Y釷�m�i���y��'L�{|r�������(ӾC���|G����w
!;�Xx�޳�W���Ŀ��sJ��8��A�"Tʈ�=��dC��=�1 �Ic��R�r@ǚK���rt��n�������ޒ�ͱ��"���o�!j�?���N��Dw2��/�
t|�`��ҹ�|�,�_���=���a �d9�[�\�����[����\q�xN��	��jp�E
�sʸ��e���,���å�{���V��8Ɓ�OUWy
O��pt��y�3P���Ve'�����=��}T�gl��:�t<�}<�$�)������kUv"���y�2��C�m瞿S=��n�<<�v�����O~�Oߞ�1�V�ͶGY�wx�\��s�p�t^߃炇���Q�Qŋ]�7@c[��;�a�~s̽�j`�
l��/�ox���kkl�՘ovn��c0f<����?ӏ�o���\�_c�n�fX�
��O�.��˜�>s���F�e���晍�o7U��Q/��x��¸}ta�b����g��OV:Ə��{A�c>�g��G__�m~<��M�����N��=�_rƷ��A+@�@ĸ\�ӣ�p��N�[�����c0L?���A�*�͏��l�����s��0�}�m��A�cU�Ҡ���c�k�D9*VdR��d��c����b�Ɩ<鍭��cb|4���y�w�7�u���ce� ߶{�c0�l�]	�~"Ɗ���V{�u��_��c0�W��|�C��Ã"�q�>{�-�N�\Wc�+4��7=�}��?��n��'�
b
����i���UYD�/V��N��[�)��E���n�c}�D���`���
ރ�㇗>�������2��;)WW~������"n��x����.�ҩ�9f]�=c�\k�����uE��͇^�h�}��\�r-�| ����
�5�p�{U��Eu�=��/}�+��=Ga�l��`\�R�m_8p��3��X;e_'ߕ��!׫tuU���0����W���m�<sI�x��R`<���L��WT8R-5zv5�b<��g��8���4`�%��!��X���0N�����
��g��
b<�~�ǷT|�*}�La\��rA��/�7����]���XhV����45b@��Ğ�3���w2�`__e9Z��Ɯe��7=��8��l�}8���/�����˛s��4AI��6��ȶ�a� ��h�24�O���R�(^���x����<ޞ���&�P4���=���EA8x�Cq`�F�>�Q�Ni���
"�.F�}�S���;�$���cn��~x�8���h1	������g��Z����G~�������b$�=�H��C!�q��RF9�Ph
 x��<�۱k쁷�gNd)R�
SFb���2��uX��t��C�_�\�,t�s}�{�g��o:<�B�2�u�d2�c@8%�͙ݣ'��<��1j����n�~ƞd<��v�4��:2!�����MR���ĉ��o�������� �0�0_�ms��{�*Ӕ�=ʓ""d�I���7{�����4}���ślX��#_�qy^t��l�*ː��+Y(:�{U��L3��nc�]W�ϳ�}��ʃ�t���l��~p~�1�vʾPe'����|����i{��ٶ�u�%a��s�\��1l?P��v�O�>�ٯ��ܺi�u~�9���V_,30O^/�_1)��F;��Pcw[��׼ <�1��&�}��˜��Y�:�5�+Z气>���1�߂���˜���P�m~���z�0�7���0�w��
c��6j��m�X���7ȶF��(�'[b|+x}���_D�c�~���{{�c��Z`�k�1�?��᪑o�u�?8���/��5�rE�&��/0�
O?N��E�^w���zn�Xc�k���uƭ��.`;(c�hx��xz�sbS�"��~��Q�^�r`�����@`<�uk�͘���XQM�q�?�/4�+4���]�?&�?���V�<�И��x\8�S:c��K��q-`{���0��X�:���2fD���1ӏ�[Ɗ��N|4�Y���il��pR�ຂs]�1&�����x�O},�/�+�q0溢���Gï�����b�~^�4?�xx��
7���q"�\W0V�u�A܈q��7�#��`��y����鎹��l�#V�ߢbťх���$�m��}�sI��V�YO�m?������π�5
���5�^���g
�B�:ֻ�S�O��I��_gXhV�<��q��Y��~�M@cA��/�v����x���H:�([������?
�^���{/�]�{�:U?�;�4��O����K����1#E�->֮���z�.�1�����r��8QF��6���>�B�e|�n�����)#��r�&����wi�P�:���ǥ�m�X�n�Y�2q,������p:���{\V�p���:^������ >O��(�ʎ��Yh��>t6���T��߅��uE�q �S�U�{\>��q��"�e�Tىlg�g�VCZ۶�u���B�x�I��cm��g�E
ھG������ӷ�em�,k�{íM;3��Ƀ�����T����[b�5�[h��#~��ر������iV��8�o���J�v
c⻲n}�a����J;k��8c��=��
c�[���il��n�|`:
㟁�o��
c�۽�׽��;���䆞V�͝��N`K�UV�Vg��H]�a������)��ǟ[���`��nu���-�R��R�ܥ�YG{vpƯ��ݠ�
���|V�J�]�����Z���1?\��և`L|��̩��knY����:�Ž1���6�˜���E߂+��*�K\���ߟk�pT��\�NjA:VЇ'Uw_��ؒ����1~L���E�u�T}��m�b��5e� _0�9{��[����Ռ���]U�}����2f4�᜽Z�c/�e���T��]j�s�}�Ɩ�'�
�+�1�c�[���b1��eq}�XA��o������K�Ή[k�/V��N�cރЏ�}^�F?� NĘ�
�
���=�1^����`��g�`k���vk	�,4��bt�?��z�_��P���{�1�6�*�/�:
c�;�KACC0���h�;�G^�e��jKc�����4T��8�U)������<9���g�J���9���y/:�����RA㥉�'ї��[�W�4�j��_d����5q��1���� �G��h�K�%�܊q��3�������/`<
�V���*M܆qM���S��g��
b��Vi?���q}�La\���:�^#�/茡�ɋ\'|����N3�)�sHG��g?7�k=�d��B����0�
���pK|����yp-�qq��@��^�ع���7�^���|�kT,�O�xN�7�^<�~��>�(�Z�)��(�9�?�&��.����n�y��g��p�s@���+I�ad|�A	?䞾3���M���W{�R/ʈ�v<�&A�O�I�')��$��,�:,�z,���#&4G�Mx�[,*���n]D��fJ��Ox̳���p��+}x�Hs��4O��RZ\�	�u+Nj��q�ZfT�E=F�杣���0��v����a"���R=8��AX̵c�;1��p�Y�΃�C��H%�Z�E4�{1�Q�q×���w�!"�������0�&���D��o�o��7�́5���������gsDXd,*5,A�)"G(�����,(D§�Q�X
2�bL������.� [Id����̛��5z��Q"r���a����"�����W#7~N�0or��\+�J�΅*00<a4��<k�)�b���c���@�
����	8��.�u=v�����+�ܚ4xh����q�R}/H͞��Bc��o^���E��U�X���MI��]��
�F�*Bk�F
.�<.�_��I�������F�B͗eaϼ����Wda��"9�켑����%����W�m�>�R}�ɲ���F�69շ&�s(c4�M���.�={���E�kި����e���{]��7��7�*�E��h8�(���)շ^�����қ��t6���Aq�T�Y\���ΙL�z��U���@�pb���c��![�A	��W��η�<�����y�e�b��	��s��{������WHɗR�Т��gZR�W���0��bVL^�L��
�y�u�v-��렘(Q<g����a�0L��8
�#����S�ʉ��Yό��|�:���3'�i,�"����b��������Vn(�Ѷt��2"��`o�7:�����6l+�,[5$�D�qW��˓��9�Ŧ]�����G+��"�K��@P��kS|WD�3���[�S$��Ŝ���"�g�<�7mD�ۤ��/���ZmD�Ww��\.'�Ll�S|����b�8�Q�=�N6��v_e��osd��߯*�A8"�������"�?NI�ZrHJ����v�"Y秠�}l�?�y��s�{��_P��3�Q���=�+z�� �L�Ux�y�q���,��f��_]��&U(�
���RC��.U(�
���RS��!U(�
���RK�)19]˅�毭t��:�Wl�o7SG��%U(�
��V��T��*Q��o��S*G�
ET���*>�"b��RB%Q�REcGU���J%L�p��#:���@��K����P�x�
ET�#ڭ$)�T��*�H[��R)Wb,%T+��B�e+	��$+�H�BU��y�q4Dt�X�Ƙ���Ȝ�ON����Y����0�Q*�
ET�E�;4X6�~h�����KX@#��!��8D�$4�͡�v���2e��I��P�kb|�f�m������7X����7���r�9�����N�%����8/a��T��J�hq[k����x�)v����\��=z���)Ǻe�D��X��\����vA�X�_ �'��RIh_���HI|p��T\��Z)N�/R�%U����<{m3�ɪ�&[�T�c��Q��"�v�=V�S�x҆"���R\�d�U�n�����O��'�$m���U]�8���e͓u�뢖v��қ����,c��T�<+�fI+k�.��X���b���ʷ�\!�c.�7��+�J/n����rpp�L�����c���PW��	<(��ӽǽ�F��>^(q�ԑ�����+���j�Q�ԕ*Q�E�J��z%Z�ľ�tR:>�COf3�oKŨ.��1u�G���=$�ڬ��tk{��J��T��*ҿKu�ƺ���L4��적��Z��9`w`)��R�"��yP��@�P@�5쀜$���~ֶ;�X�4�*�A�S�V�Ye+�K�еmZF�d��q(�
O+�,@�i"�h�K4�3�fϑ*�Sh��s�Ri*U��P��J��TIQ*TU�0�g�'���kĐ�M��{�>d`��o��k��Eԯt�,on��/S�����.%%)R�GIf�ז���#_��ɑb
��'�ފ3�\v] �o��y���
7��Tq�[�~jD��9_9�NVN�Mt�#[v���!�/��bDd��.�.�kҋir-���a�CM�� x��j��(��_t2�"�n���-
���u2���D��{C
8fU�������(�l�J|�K?�#j}��>�'{D��d���*��.�q�rߖ#j#=�J%��iI���(	�����:m�Vir�G�Jq;YqHH�Z�>Xq�OMZk��A���\�9�:ʹ�I���)c��<��&U(�
玭r�R�T���(
,�P�?L�t�:�26Cw���Tҥ
�U�j��+��`�j��P*�T�C�z��r�R�"U(�
=�V)P*K���3k��T*]�
ET�)�UF)�n%�RBe�R�.Ur��|ۭ�NR�BU䉷/2��rdlp(��~�Y;C�f-֦_��U*X`(���X�q6H�i�Ñd���xk�484&��X�Cf�Kdm�4R
��2~2����C�ȟ �%�1/�%+�6<�I�3T�[c�tZ&�{��M!U�T�^R�J��/=+��<+J�YV��'z֑���2����'����[��S�T%���x|f�_OS�/�����Hq��^�$��Z#}p���
V�V�7�Į�/��c�6.7}q����K~�)�R^<'_9NWC��bxq�h9����J���1QoC?)������'t��A�uJܼջB��vg*�u����^�8+��� Y�r���<Yܯ�K\�(Y��M��e~e�.1�f�P��s%�2�K�<��	��%^g���(G4X�u���e45j�"%C�oT��[,�A�MJ|S-�Q����v�lw��d-�iT��AJ��)�6ƛ�K�UZ��1g�0939��v�T�K���	`��G��K���I`�+�R�"���`Ƿ@�26�t�<z���ղ6k�6'���J�@�PD:��r�R)U(���t�El�i�<z���(Yۏ_�=�����v�2Z�PD��4*ĽйM?9;(��Y��99��T*c�
ET�^ڂ@���{�ְ"�������U�2N�h�J�ܣT��
� �ya�B���x��-���r�R� U8m�
'��r�R�XB��Vy@�L�*�}ٚ��R�,U8����P��J�g �*�BUR*SKtDU��`��W����3�Ŋ�/{\Bq���9�)s|]<W�_�K_��o3�[3G��ɳE�Y��o>Q��d7��d�-掗�y����M�3��K��oXi\?`����
Jܪý�ΗI���$S��2�4\�V|G�_�:ʮ83��c^��0�_8�F��~�����ZZ�+�F5���'9-L9�Yr월�Ϻ�Ơr��Y��nH�;�e��A����n5�����=%^x�B��9A���zT7�Q��$O��ol�g��`�����v�o��\-���@��6O�&}�γoρ���R�"���.�� ���Zg��3_֡����n�#���BU��
w�B��>�G����.��Y���>v۔�-R�"����*�(�[�
ET���vC���ˣ�O�1�&k�k�
�v(�R�"�HW(�A�Q( �G����.k�k�S�v)�;�
ET�^:�ſ	���@��<;�S���`3K�U��T�K�h�J��Q*wK�C�K��ϔ�=%T�J�p/~�5�ʁ�ȅI��E��o~I���ox�_BΘ���:cm�[d�}!��t���z��\� �j�_�y�M���=5�d7�Wd�moғFx�eo�����?>f��Q(���(�����K�B���S�m{'C�N�����+������y��0w����=��s�#]ji#�5��CFO��T��;�<�o�$}w���x[)y48��B*6�#I��*q��ن?����j7�((�!���b9���@�
F�yO�n���CJ��O�����Iɒ`�?)��7�4��8ړA��J|p�V�@/����l�-���-���`��J�S����Ȋ�h��+��ڙŶQ�a|6i�`�"�!��>��D��B�T�⪖�m�Ԋn(�(�@��
BB�4����H�o�}_)z�m�}�.q*]��|3���f�x�Քz�&��ZsV�ϗ�d�$*�D1Kv���&Q�$��X�+�<hIb8m��N.5�c�>��Jes��V-�V|��%�&Q�$��X�'�<dIb�4�C#Ԡ����TU*[m�Rm�Y�d(y�$*��bmZ�F�3�U���Q��Z��P�;Ю(I3��$#����eՠ��F(�ڏ[�h�(�;�T�!�D��N2+�<a�mj
︕�P�d�D!KXӭ��L�Z�%��o��M����D?8��p�D1K
%��u��B	��z&�Z`+C�^b�Web�۔8�����A�fN��l���{�N��b��:�L>�gJ~.��|���ʦ�e��,��lgW:�}{��ey�����05�t���t������ruߙ����5W='{�lo�*:�sf��U�~v��sun�?e��#S=�oO���j7�)�*=]���lH��Ϧ�֙��V-�X��twh(9�Ṷ��Pr�"oqu�K���m�1Co01mw�?�U�9���ڝɔ�b�P��r!�</�Kk���9X��9�w32�eh�e���m�f��qO[O[F]�x�k1�D�N��F���O?G��ך�p0�(J��4��(J���V�i�ki�E�b���d�ߕ�u.���s~���7'f9
��|���ه�.��Ľlsu�ĸ�j��
\�%P�K�.���
���������p=���F�	n��p��[�6���Xw�]���������Ei�g\T4꽉�9���"�/�+�*���l�7�Mxކw�]xއ�C�>�O�S���s�d2��L*f���7��F�
|����?����
��l��a��?�/�;`'�	�
{`/L�b@ϴ�)�g�z:hj}�>�XL��y���w!:��_)w��Q=)�>S�|;5w'���F/"=�A{��je��9p�2͠����ק�$$If�!vh5��
5��5��5��
#v�
#v�#v�#v�
:V�l
t��0�������6�5��
5��5��5��
yt�&.�T�$$If�!vh5��
5��5��5��
#v�
#v�#v�#v�
:V�l
t��0�������6�5��
5��5��5��
yt�&.�T�$$If�!vh5��
5��5��5��
#v�
#v�#v�#v�
:V�l
t��0�������6�5��
5��5��5��
yt�&.�T�$$If�!vh5��
5��5��5��
#v�
#v�#v�#v�
:V�l
t��0�������6�5��
5��5��5��
yt�&.�T�$$If�!vh5��
5��5��5��
#v�
#v�#v�#v�
:V�l
t��0�������6�5��
5��5��5��
yt�&.�T�$$If�!vh5��
5��5��5��
#v�
#v�#v�#v�
:V�l
t��0�������6�5��
5��5��5��
yt�&.�T�$$If�!vh5��
5��5��5��
#v�
#v�#v�#v�
:V�l
t��0�������6�5��
5��5��5��
yt�&.�T�$$If�!vh5��
5��5��5��
#v�
#v�#v�#v�
:V�l
t��0�������6�5��
5��5��5��
yt�&.�T�$$If�!vh5��
5��5��5��
#v�
#v�#v�#v�
:V�l
t��0�������6�5��
5��5��5��
yt�&.�TulationAdministratorNormal.dotmAdministrator4Microsoft Office Word@��G@X����@V�=��@�o��&BE����՜.��+,��D��՜.��+,���Lhp��������
�,�0Miller School Of Medicine (University Of Miami)�)DocumentSummaryInformation8�������������CompObj������������,y������������������������?Q8The use of designer drugs in the psychiatric populationTitle` 8@_PID_HLINKS�A*/9,http://www.ncbi.nlm.nih.gov/pubmed/21810934~S&ahttp://www.ncbi.nlm.nih.gov/pubmed?term=Ellis%20JD%5BAuthor%5D&cauthor=true&cauthor_uid=21810934~%X_http://www.ncbi.nlm.nih.gov/pubmed?term=Chu%20PW%5BAuthor%5D&cauthor=true&cauthor_uid=21810934~"	dhttp://www.ncbi.nlm.nih.gov/pubmed?term=McFadden%20LM%5BAuthor%5D&cauthor=true&cauthor_uid=21810934~*`http://www.ncbi.nlm.nih.gov/pubmed?term=Webb%20KM%5BAuthor%5D&cauthor=true&cauthor_uid=21810934~PAMhttp://www.aapcc.org.dnn/Portals/0/Bath Salts data for Websites 1.5.2012.pdf~,{Shttp://drugs.homeoffice.gov.uk/publication-search/acmd/ACMD-cathinones-report.html~��
����	�F'Microsoft Office Word 97-2003 Document
MSWordDocWord.Document.8�9�qf%���������666666666vvvvvvvvv666666>666666666666666666666666666�6666666666�666666666666hH66666666666666666666666666666666666666666666666666666666666666666�62���� 0@P`p������2(�� 0@P`p������ 0@P`p������ 0@P`p������ 0@P`p������ 0@P`p������ 0@P`p��8X�V~OJQJ_HmH	nH	sH	tH	N`�N�mNormal$a$ CJOJQJ_HaJmH	sH	tH	l`l*��	Heading 1$�d�d@&[$\$a$&5�CJ0KH$OJQJ\�aJ0mHsHtHDA`�DDefault Paragraph FontRi@�R0Table Normal�4�
l4�a�(k �(
0No Listt���t+��
Table Grid7:V�0������d��B' �B
$0Comment ReferenceCJaJH H
$0Comment TextCJaJmHsHtHN�/�!N$0Comment Text CharCJOJQJ^JaJ@j @
$0Comment Subject5�\�Z�/�AZ$0Comment Subject Char5CJOJQJ\^JaJP� RP
$0Balloon TextCJOJQJaJmHsHtHN�/�aN$0Balloon Text CharCJOJQJ^JaJ@ r@� �0Header

�H�$mHsHtHB�/�B� �0Header CharCJOJQJ^JaJ@ `�@� �0Footer

�H�$mHsHtHB�/�B� �0Footer CharCJOJQJ^JaJ4���4�=reference-text4U`�4*�0	Hyperlink	>*ph�N�/��N*��Heading 1 Char5CJ0KH$OJQJ\aJ0FV ��F
0FollowedHyperlink>*B*ph��l� ��lku0Medium List 2 - Accent 2 CJOJQJ_HaJmH	sH	tH	*�O�*}\	highlight.�O�.�ref-journalB�O�!B�apple-converted-space&�O�1&�ref-vol$��A$�nowrapPK!����[Content_Types].xml���j�0E����ж�r�(��΢Iw},��-j��4	��w�P�-t#bΙ{U�����T�U^h�d}㨫��)��*1P�'��	�^��W��0)��T�9<�l�#��$yi}��;�~@��(��H����u�*Dנz��/0�ǰ��$��X��3aZ����,�D0j~�3߶�b��~i>���3�\`�?�/�[���G��\�!�-�Rk.�s�Ի�..���a濭?��PK!�֧�6_rels/.rels���j�0���}Q��%v/��C/�}�(h"���O�
����=������ ����C?�h�v=��Ʌ��%[xp��{۵_�Pѣ<�1�H�0���O�R�Bd���JE�4b$��q_����6L�R�7`������0̞O��,�En7�Li�b��/�S���e��е�����PK!ky���theme/theme/themeManager.xml�M
� @�}�w��7c�(Eb�ˮ��C�AǠҟ����7��՛K
Y,�
�e�.���|,���H�,l����xɴ��I�sQ}#Ր���� ֵ+�!�,�^�$j=�GW��)�E�+&
8���PK!����Ptheme/theme/theme1.xml�YOo�6��w toc'vu�ر�-M�n�i���P�@�I}��úa��m�a[�إ�4�:lЯ�GR��X^�6؊�>$�������!)O�^�r�C$�y@�����/�yH*��񄴽)�޵��߻��UDb�`}"�qۋ�Jח���X^�)I`n�E���p)���li�V[]�1M<������O�P��6r�=���z�gb�Ig��u��S�eb��O������R�D۫����qu	�g��Z����o~ٺlAp�lx�pT0���+[}`j���zA��V�2�F���i�@�q�v�֬5\|��ʜ̭N��le�X�ds���jcs���7���f����
��W��+�Ն�7����`���g�Ș��J���j|��h(�K��D-����
dX��iJ�؇(��x$(��:��;�˹!�I_�T��S1�����?E��?�����?ZBΪm���U/������?�~����xY���'���y5�g&΋/����ɋ�>���G�M�Ge���D�����3Vq%'#q�����$�8��K�����)f�w9:ĵ��
x}r�x����w���r�:\TZaG�*�y8I�j�bR��c|XŻ�ǿ�I
u3KG�nD1�NIB�s���
��R��u���K>V�.EL+M2�#'�f��i~�V��vl�{u8��z��H�
�*���:�(W�☕
~��J�T�e\O*�tHG��HY��}KN�P�*ݾ˦���TѼ�9/#��A7�qZ��$*c?���qU��n��w�N��%��O��i�4=3ڗP��
����1�P�m\\9���������Mؓ�2a�D�]�;Yt�\��[x����]�}Wr��|�]��g-���
eW�
�)6-r��CS�j��
i�d	�DЇA�ΜIqbJ#x�꺃6k���#��A�Sh��&ʌt(Q�%��p%m��&]�caSl=�X�����\P�1�Mh�9�M��V�dDA��aV�B��[݈fJ�íP|8�քA�V^��f
�H��n���-��"�d>�z��n��NJ�	�ة�>�b���&����2��v����Kyϼ��D:����,AGm��\nz��i�Ù��.uχYC�6�OMf��3o�r��$��5�����NH�T[XF64�T,ќ���M0�E)`#�5�XY�`�פ;��%�1�U�٥m;���R>QD����D�cp�U�'��&LE�/p���m���%]�����8fi��r�S4�d7y\�`�J�n���ί�I�R��3U�~7+���׸#��m�q�BiD���������i*�L6�9�m�Y&���i���HE��=(K&�N!V�.K�e�LD�ĕ�{D	����vEꦚde��NƟ��e�(�MN9ߜR�6����&3(��a���/D��U�z�<�{ˊ�Y��ȳ����V���)�9�Z[��4^n��5���!J��?��Q�3�eBo�C����M����m<�.�vp�����IY�f���Z�Y_p�[�=al-�Y�}Nc͙���ŋ4vfa��vl����'S��A�8�|�*u�{��-�ߟ0%M0�7%����<���ҍ���PK!
ѐ��'theme/theme/_rels/themeManager.xml.rels��M
�0���wooӺ�&݈Э���5
6?$Q��
�,.�a��i����c2�1h�:�q��m��@RN��;d�`��o7�g�K(M&$R(.1�r'J��ЊT���8��V�"��AȻ�H�u}��|�$�b{��P����8�g/]�QAsم(����#��L�[������PK-!����[Content_Types].xmlPK-!�֧�6+_rels/.relsPK-!ky���theme/theme/themeManager.xmlPK-!����P�theme/theme/theme1.xmlPK-!
ѐ��'�	theme/theme/_rels/themeManager.xml.relsPK]�
<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<a:clrMap xmlns:a="http://schemas.openxmlformats.org/drawingml/2006/main" bg1="lt1" tx1="dk1" bg2="lt2" tx2="dk2" accent1="accent1" accent2="accent2" accent3="accent3" accent4="accent4" accent5="accent5" accent6="accent6" hlink="hlink" folHlink="folHlink"/>�Q�����	ZZyyy|�	��%�)�(�+o2�6
;�>�L#P�QeRST�W�X�Y�̓-/012346789:<=?@ABDEFT(�;�L�TF�̑��=�b�����
�L�T�̓.5;>CJKLMNOPQRSUjA�ABxB�B4C�HDIMIPI�I�I�I?JGJJJ�J�J7K�K�KbN�N�N�QX��X��X��X��X��X��X��:����Zru|!����8�@�����������0�(	��G
��B
�S����	?���
_Hlt343700990
_Hlt343700991
_Hlt343700993
_Hlt330206621
_Hlt330206622
_Hlt339895861
_Hlt339895862�A�A�A3C3C�K�K�Q@@@@@@@�A�A�A4C4C�K�K�Q���Zr'(-.MNS]kl�������j
s
��`ckmnq�������#�#
AARCsC�C�C�C�C�C�C�C,D-D@DADCDGDNDODQDRDsDtD�D�DEEE$E,E�F�F�F�F�F�F�F�FGG3G�GHH)H0H�H�H�H�H�K�K�K�K�K�K�M�M�M�M�M�M�MN NHNJNQNzP�P�P�PhQjQkQmQnQpQqQsQtQ�Q�Q
AA<DCD�D�DFTFUFoF4G6G�G�G�G�G2HMH�K�K	LlLmL�L�LtM�M�M�M�MhQjQkQmQnQpQqQsQtQ�Q�Q333333333333������TTxx����dd
A
A2A8AjAB�M�MHNJN�N�N�P�PgQhQ�Q�Q�Q����r���������=f��X���������l�������������KY�.�!Z���������Tz���������������^�`�OJQJo(�8�����^�8`���OJQJo(��������^�`���OJQJ^Jo(o��	����p^��	`���OJQJo(��������@^��`���OJQJo(���x����^�x`���OJQJo(���H�����^�H`���OJQJ^Jo(o������^�`���OJQJo(���������^��`���OJQJo(�������^��`���o()�
�����^��`����h�H.�
�p�L�^�p`�L��h�H.�
�@���^�@`����h�H.�
����^�`����h�H.�
���L�^��`�L��h�H.�
�����^��`����h�H.�
�����^��`����h�H.�
�P�L�^�P`�L��h�H.�����^��`���o()�
�����^��`����h�H.�
�p�L�^�p`�L��h�H.�
�@���^�@`����h�H.�
����^�`����h�H.�
���L�^��`�L��h�H.�
�����^��`����h�H.�
�����^��`����h�H.�
�P�L�^�P`�L��h�H.�����^��`���o(.
�����^��`����h�H.�
�p�L�^�p`�L��h�H.�
�@���^�@`����h�H.�
����^�`����h�H.�
���L�^��`�L��h�H.�
�����^��`����h�H.�
�����^��`����h�H.�
�P�L�^�P`�L��h�H.�������^��`���.�������^��`���.��p����p^�p`���.��@����@^�@`���.������^�`���.��������^��`���.��������^��`���.��������^��`���.��P����P^�P`���.KY�.Tzl����=f������������������������																											(�^o1TgQ��T�4
�mb>�k��W�n.
BYW4
�z
e~Gx�bG\^,9%e%e�^��#6'�$6'�$;�f�v�.FAs�Rm9kw�\r0=YW�mb>�bG��A�k�n.
Bw�Cw�C�?v]�D��Ae~G�Rm9��GX�GX�G�PpK�PpK^,9��M�W�o1T,5�[WO2|\kw�\gQ��?v]M*$_,5�[;�fr0=��f�sw,�k�B�v�F�rw,�kFAs�D�s��G�B�v�v�.WO2|��M����^r'}\�k�1
2
@C�Rt�/�R�_�o�9
�JI|�|T�#C]
�!�<�-�~��PZ�g�m�0!|"xu"A#$G$�x$�3'�5'(0+�k,�U-�&.�Y/�0�11�X4[_5�j5�6yL7}9
:�k<�P=�q@T}BCCPJF�aG�aI�8J�N�ON�jN�BO'TQ�S�RS�US?pS�T�(T�1T�U+V;-WX�[N]ab�"cBc-pfh:HhYi�ktm�Npq�%q':r�Arku�v�1w�ywXuz�u{�s|e3}Rp}�J��U��q��)��z��L���
2��>�]M�%<�&?�P�u �M�N��a�I���}�}3�DJ��%��Q��T�YW�U~�HC��F�=��sW�fY�	@�]�������H��x��_f�IO��@��;�""��q�Qg�Xi�$��[�3}�x��
�^��4���d%��y�5�2G�	r�)M�{R�va�^V�*M��"��X�Rk��x�v��8�4L�>��1�+C���%��,��x��T��6�l5��Y��	�\��}�3J����UI��n���n]��x�����rA��R�@W��^�$��;��8�#W�(��v�Lp��B�hQjQ�@�
A
A��
A
AL#$N�Q`@`"`L@`.``@` @��Unknown������������G��* ��Times New Roman5��Symbol3.��* ��Arial7.���{ @�Calibri5.��*a��Tahoma?=�	�* ��Courier New;��WingdingsA���� B�Cambria Math"q����h�g�g��&BE)��&BE)�����x���24?Q?Q3�Q���HX	�$P����������������������Oh-2!xx���7The use of designer drugs in the psychiatric population
Administrator
Administrator 

Youez - 2016 - github.com/yon3zu
LinuXploit