����JFIFXX�����    $.' ",#(7),01444'9=82<.342  2!!22222222222222222222222222222222222222222222222222����"��4�� ���,�PG"Z_�4�˷����kjز�Z�,F+��_z�,�© �����zh6�٨�ic�fu���#ډb���_�N�?��wQ���5-�~�I���8����TK<5o�Iv-�����k�_U_�����~b�M��d����Ӝ�U�Hh��?]��E�w��Q���k�{��_}qFW7HTՑ��Y��F�?_�'ϔ��_�Ջt��=||I ��6�έ"�����D���/[�k�9���Y�8ds|\���Ҿp6�Ҵ���]��.����6�z<�v��@]�i%��$j��~�g��J>��no����pM[me�i$[����s�o�ᘨ�˸ nɜG-�ĨU�ycP�3.DB�li�;��hj���x7Z^�N�h������N3u{�:j�x�힞��#M&��jL P@_���� P��&��o8������9�����@Sz6�t7#O�ߋ �s}Yf�T���lmr����Z)'N��k�۞p����w\�Tȯ?�8`�O��i{wﭹW�[�r�� ��Q4F�׊���3m&L�=��h3����z~��#�\�l :�F,j@�� ʱ�wQT����8�"kJO���6�֚l����}���R�>ډK���]��y����&����p�}b��;N�1�m�r$�|��7�>e�@B�TM*-iH��g�D�)� E�m�|�ؘbҗ�a��Ҿ����t4���o���G��*oCN�rP���Q��@z,|?W[0�����:�n,jWiE��W��$~/�hp\��?��{(�0���+�Y8rΟ�+����>S-S����VN;�}�s?.����� w�9��˟<���Mq4�Wv'��{)0�1mB��V����W[�����8�/<� �%���wT^�5���b��)iM� pg�N�&ݝ��VO~�q���u���9� ����!��J27����$O-���! �:�%H��� ـ����y�ΠM=t{!S�� oK8������t<����è:a������[�����ա�H���~��w��Qz`�po�^ ����Q��n� �,uu�C�$ ^���,������8�#��:�6��e�|~���!�3�3.�\0��q��o�4`.|� ����y�Q�`~;�d�ׯ,��O�Zw�������`73�v�܋�<���Ȏ�� ـ4k��5�K�a�u�=9Yd��$>x�A�&�� j0� ���vF��� Y�|�y��� ~�6�@c��1vOp�Ig����4��l�OD���L����� R���c���j�_�uX6��3?nk��Wy�f;^*B� ��@�~a�`��Eu������+���6�L��.ü>��}y���}_�O�6�͐�:�YrG�X��kG�����l^w���~㒶sy��Iu�!� W ��X��N�7BV��O��!X�2����wvG�R�f�T#�����t�/?���%8�^�W�aT��G�cL�M���I��(J����1~�8�?aT ���]����AS�E��(��*E}� 2��#I/�׍qz��^t�̔���b�Yz4x���t�){ OH��+(E��A&�N�������XT��o��"�XC��'���)}�J�z�p� ��~5�}�^����+�6����w��c��Q�|Lp�d�H��}�(�.|����k��c4^�"�����Z?ȕ ��a<�L�!039C� �Eu�C�F�Ew�ç ;�n?�*o���B�8�bʝ���'#Rqf���M}7����]����s2tcS{�\icTx;�\��7K���P���ʇ Z O-��~��c>"��?�������P��E��O�8��@�8��G��Q�g�a�Վ���󁶠�䧘��_%#r�>�1�z�a��eb��qcPѵ��n���#L��� =��׀t� L�7�`��V���A{�C:�g���e@�w1 Xp3�c3�ġ����p��M"'-�@n4���fG��B3�DJ�8[Jo�ߐ���gK)ƛ��$���� ���8�3�����+���� �����6�ʻ���� ���S�kI�*KZlT _`���?��K����QK�d����B`�s}�>���`��*�>��,*@J�d�oF*����弝��O}�k��s��]��y�ߘ��c1G�V���<=�7��7����6�q�PT��tXԀ�!9*4�4Tހ3XΛex�46���Y��D ����� �BdemDa����\�_l,��G�/���֌7���Y�](�xTt^%�GE�����4�}bT���ڹ�����;Y)���B�Q��u��>J/J �⮶.�XԄ��j�ݳ�+E��d ��r�5�_D�1 ��o�� �B�x�΢�#���<��W�����8���R6�@g�M�.��� dr�D��>(otU��@x=��~v���2� ӣ�d�oBd��3�eO�6�㣷�����ݜ6��6Y��Qz`��S��{���\P�~z m5{J/L��1������<�e�ͅPu�b�]�ϔ���'������f�b� Zpw��c`"��i���BD@:)ִ�:�]��hv�E�w���T�l��P���"Ju�}��وV J��G6��. J/�Qgl߭�e�����@�z�Zev2u�)]կ�����7x���s�M�-<ɯ�c��r�v�����@��$�ޮ}lk���a���'����>x��O\�ZFu>�����ck#��&:��`�$�ai�>2Δ����l���oF[h��lE�ܺ�Πk:)���`�� $[6�����9�����kOw�\|���8}������ބ:��񶐕��I�A1/�=�2[�,�!��.}gN#�u����b��� ~��݊��}34q����d�E��Lc��$��"�[q�U�硬g^��%B �z���r�pJ�ru%v\h1Y�ne`ǥ:g���pQM~�^�Xi� ��`S�:V29.�P���V�?B�k�� AEvw%�_�9C�Q����wKekPؠ�\�;Io d�{ ߞo�c1eP����\� `����E=���@K<�Y���eڼ�J���w����{av�F�'�M�@/J��+9p���|]�����Iw &`��8���&M�hg��[�{��Xj��%��Ӓ�$��(����ʹN���<>�I���RY���K2�NPlL�ɀ)��&e����B+ь����( � �JTx���_?EZ� }@ 6�U���뙢ط�z��dWI�n` D����噥�[��uV��"�G&Ú����2g�}&m��?ċ�"����Om#��������� ��{�ON��"S�X��Ne��ysQ���@Fn��Vg���dX�~nj�]J�<�K]:��FW��b�������62�=��5f����JKw��bf�X�55��~J �%^����:�-�QIE��P��v�nZum� z � ~ə ���� ���ة����;�f��\v���g�8�1��f24;�V���ǔ�)����9���1\��c��v�/'Ƞ�w�������$�4�R-��t���� e�6�/�ġ �̕Ecy�J���u�B���<�W�ַ~�w[B1L۲�-JS΂�{���΃������A��20�c#��@ 0!1@AP"#2Q`$3V�%45a6�FRUq��� ����^7ׅ,$n�������+��F�`��2X'��0vM��p�L=������5��8������u�p~���.�`r�����\���O��,ư�0oS ��_�M�����l���4�kv\JSd���x���SW�<��Ae�IX����������$I���w�:S���y���›R��9�Q[���,�5�;�@]�%���u�@ *ro�lbI �� ��+���%m:�͇ZV�����u�̉����θau<�fc�.����{�4Ա� �Q����*�Sm��8\ujqs]{kN���)qO�y�_*dJ�b�7���yQqI&9�ԌK!�M}�R�;������S�T���1���i[U�ɵz�]��U)V�S6���3$K{�ߊ<�(� E]Զ[ǼENg�����'�\?#)Dkf��J���o��v���'�%ƞ�&K�u�!��b�35LX�Ϸ��63$K�a�;�9>,R��W��3�3� d�JeTYE.Mϧ��-�o�j3+y��y^�c�������VO�9NV\nd�1 ��!͕_)a�v;����թ�M�lWR1��)El��P;��yوÏ�u 3�k�5Pr6<�⒲l�!˞*��u־�n�!�l:����UNW ��%��Chx8vL'��X�@��*��)���̮��ˍ��� ���D-M�+J�U�kvK����+�x8��cY������?�Ԡ��~3mo��|�u@[XeY�C�\Kp�x8�oC�C�&����N�~3-H���� ��MX�s�u<`���~"WL��$8ξ��3���a�)|:@�m�\���^�`�@ҷ)�5p+��6���p�%i)P M���ngc�����#0Aruz���RL+xSS?���ʮ}()#�t��mˇ!��0}}y����<�e� �-ή�Ԩ��X������ MF���ԙ~l L.3���}�V뽺�v�����멬��Nl�)�2����^�Iq��a��M��qG��T�����c3#������3U�Ǎ���}��לS�|qa��ڃ�+���-��2�f����/��bz��ڐ�� �ݼ[2�ç����k�X�2�* �Z�d���J�G����M*9W���s{��w���T��x��y,�in�O�v��]���n����P�$�JB@=4�OTI�n��e�22a\����q�d���%�$��(���:���: /*�K[PR�fr\nڙdN���F�n�$�4�[�� U�zƶ����� �mʋ���,�ao�u 3�z� �x��Kn����\[��VFmbE;�_U��&V�Gg�]L�۪&#n%�$ɯ�dG���D�TI=�%+AB�Ru#��b4�1�»x�cs�YzڙJG��f��Il��d�eF'T� iA��T���uC�$����Y��H?����[!G`}���ͪ� �纤Hv\������j�Ex�K���!���OiƸ�Yj�+u-<���'q����uN�*�r\��+�]���<�wOZ.fp�ێ��,-*)V?j-kÊ#�`�r��dV����(�ݽBk�����G�ƛk�QmUڗe��Z���f}|����8�8��a���i��3'J�����~G_�^���d�8w������ R�`(�~�.��u���l�s+g�bv���W���lGc}��u���afE~1�Ue������Z�0�8�=e�� f@/�jqEKQQ�J��oN��J���W5~M>$6�Lt�;$ʳ{���^��6�{����v6���ķܰg�V�cnn �~z�x�«�,2�u�?cE+Ș�H؎�%�Za�)���X>uW�Tz�Nyo����s���FQƤ��$��*�&�LLXL)�1�" L��eO��ɟ�9=���:t��Z���c��Ž���Y?�ӭV�wv�~,Y��r�ۗ�|�y��GaF�����C�����.�+� ���v1���fήJ�����]�S��T��B��n5sW}y�$��~z�'�c ��8 ��� ,! �p��VN�S��N�N�q��y8z˱�A��4��*��'������2n<�s���^ǧ˭P�Jޮɏ�U�G�L�J�*#��<�V��t7�8����TĜ>��i}K%,���)[��z�21z ?�N�i�n1?T�I�R#��m-�����������������1����lA�`��fT5+��ܐ�c�q՝��ʐ��,���3�f2U�եmab��#ŠdQ�y>\��)�SLY����w#��.���ʑ�f��� ,"+�w�~�N�'�c�O�3F�������N<���)j��&��,-� �љ���֊�_�zS���TǦ����w�>��?�������n��U仆�V���e�����0���$�C�d���rP �m�׈e�Xm�Vu� �L��.�bֹ��� �[Դaզ���*��\y�8�Է:�Ez\�0�Kq�C b��̘��cө���Q��=0Y��s�N��S.���3.���O�o:���#���v7�[#߫ ��5�܎�L���Er4���9n��COWlG�^��0k�%<���ZB���aB_���������'=��{i�v�l�$�uC���mƎҝ{�c㱼�y]���W�i ��ߧc��m�H� m�"�"�����;Y�ߝ�Z�Ǔ�����:S#��|}�y�,/k�Ld� TA�(�AI$+I3��;Y*���Z��}|��ӧO��d�v��..#:n��f>�>���ȶI�TX��� 8��y����"d�R�|�)0���=���n4��6ⲑ�+��r<�O�܂~zh�z����7ܓ�HH�Ga롏���nCo�>������a ���~]���R���̲c?�6(�q�;5%� |�uj�~z8R=X��I�V=�|{v�Gj\gc��q����z�؋%M�ߍ����1y��#��@f^���^�>N�����#x#۹��6�Y~�?�dfPO��{��P�4��V��u1E1J �*|���%���JN��`eWu�zk M6���q t[�� ��g�G���v��WIG��u_ft����5�j�"�Y�:T��ɐ���*�;� e5���4����q$C��2d�}���� _S�L#m�Yp��O�.�C�;��c����Hi#֩%+) �Ӎ��ƲV���SYź��g |���tj��3�8���r|���V��1#;.SQ�A[���S������#���`n�+���$��$I �P\[�@�s��(�ED�z���P��])8�G#��0B��[ى��X�II�q<��9�~[Z멜�Z�⊔IWU&A>�P~�#��dp<�?����7���c��'~���5 ��+$���lx@�M�dm��n<=e�dyX��?{�|Aef ,|n3�<~z�ƃ�uۧ�����P��Y,�ӥQ�*g�#먙R�\���;T��i,��[9Qi歉����c>]9�� ��"�c��P�� �Md?٥��If�ت�u��k��/����F��9�c*9��Ǎ:�ØF���z�n*�@|I�ށ9����N3{'��[�'ͬ�Ҳ4��#}��!�V� Fu��,�,mTIk���v C�7v���B�6k�T9��1�*l� '~��ƞF��lU��'�M ����][ΩũJ_�{�i�I�n��$���L�� j��O�dx�����kza۪��#�E��Cl����x˘�o�����V���ɞ�ljr��)�/,�߬h�L��#��^��L�ф�,íMƁe�̩�NB�L�����iL����q�}��(��q��6IçJ$�W�E$��:������=#����(�K�B����zђ <��K(�N�۫K�w��^O{!����)�H���>x�������lx�?>Պ�+�>�W���,Ly!_�D���Ō�l���Q�!�[ �S����J��1��Ɛ�Y}��b,+�Lo�x�ɓ)����=�y�oh�@�꥟/��I��ѭ=��P�y9��� �ۍYӘ�e+�p�Jnϱ?V\SO%�(�t� ���=?MR�[Ș�����d�/ ��n�l��B�7j� ��!�;ӥ�/�[-���A�>�dN�sLj ��,ɪv��=1c�.SQ�O3�U���ƀ�ܽ�E����������̻��9G�ϷD�7(�}��Ävӌ\�y�_0[w ���<΍>����a_��[0+�L��F.�޺��f�>oN�T����q;���y\��bՃ��y�jH�<|q-eɏ�_?_9+P���Hp$�����[ux�K w�Mw��N�ی'$Y2�=��q���KB��P��~������Yul:�[<����F1�2�O���5=d����]Y�sw:���Ϯ���E��j,_Q��X��z`H1,#II ��d�wr��P˂@�ZJV����y$�\y�{}��^~���[:N����ߌ�U�������O��d�����ؾe��${p>G��3c���Ė�lʌ�� ת��[��`ϱ�-W����dg�I��ig2��� ��}s ��ؤ(%#sS@���~���3�X�nRG�~\jc3�v��ӍL��M[JB�T��s3}��j�Nʖ��W����;7��ç?=X�F=-�=����q�ߚ���#���='�c��7���ڑW�I(O+=:uxq�������������e2�zi+�kuG�R��������0�&e�n���iT^J����~\jy���p'dtG��s����O��3����9* �b#Ɋ�� p������[Bws�T�>d4�ۧs���nv�n���U���_�~,�v����ƜJ1��s�� �QIz��)�(lv8M���U=�;����56��G���s#�K���MP�=��LvyGd��}�VwWBF�'�à �?MH�U�g2�� ����!�p�7Q��j��ڴ����=��j�u��� Jn�A s���uM������e��Ɔ�Ҕ�!)'��8Ϣ�ٔ��ޝ(��Vp���צ֖d=�IC�J�Ǡ{q������kԭ�߸���i��@K����u�|�p=..�*+����x�����z[Aqġ#s2a�Ɗ���RR�)*HRsi�~�a &f��M��P����-K�L@��Z��Xy�'x�{}��Zm+���:�)�) IJ�-i�u���� ���ܒH��'�L(7�y�GӜq���� j��� 6ߌg1�g�o���,kر���tY�?W,���p���e���f�OQS��!K�۟cҒA�|ս�j�>��=⬒��˧L[�� �߿2JaB~R��u�:��Q�] �0H~���]�7��Ƽ�I���(}��cq '�ήET���q�?f�ab���ӥvr� �)o��-Q��_'����ᴎo��K������;��V���o��%���~OK ����*��b�f:���-ťIR��`B�5!RB@���ï�� �u �̯e\�_U�_������� g�ES��3�������QT��a����x����U<~�c?�*�#]�MW,[8O�a�x��]�1bC|踤�P��lw5V%�)�{t�<��d��5���0i�XSU��m:��Z�┵�i�"��1�^B�-��P�hJ��&)O��*�D��c�W��vM��)����}���P��ܗ-q����\mmζZ-l@�}��a��E�6��F�@��&Sg@���ݚ�M����� ȹ 4����#p�\H����dYDo�H���"��\��..R�B�H�z_�/5˘����6��KhJR��P�mƶi�m���3�,#c�co��q�a)*Pt����R�m�k�7x�D�E�\Y�閣_X�<���~�)���c[[�BP����6�Yq���S��0����%_����;��Àv�~�| VS؇ ��'O0��F0��\���U�-�d@�����7�SJ*z��3n��y��P����O���������m�~�P�3|Y��ʉr#�C�<�G~�.,! ���bqx���h~0=��!ǫ�jy����l�O,�[B��~��|9��ٱ����Xly�#�i�B��g%�S��������tˋ���e���ې��\[d�t)��.+u�|1 ������#�~Oj����hS�%��i.�~X���I�H�m��0n���c�1uE�q��cF�RF�o���7� �O�ꮧ� ���ۛ{��ʛi5�rw?׌#Qn�TW��~?y$��m\�\o����%W� ?=>S�N@�� �Ʈ���R����N�)�r"C�:��:����� �����#��qb��Y�. �6[��2K����2u�Ǧ�HYR��Q�MV��� �G�$��Q+.>�����nNH��q�^��� ����q��mM��V��D�+�-�#*�U�̒ ���p욳��u:�������IB���m���PV@O���r[b= �� ��1U�E��_Nm�yKbN�O���U�}�the�`�|6֮P>�\2�P�V���I�D�i�P�O;�9�r�mAHG�W�S]��J*�_�G��+kP�2����Ka�Z���H�'K�x�W�MZ%�O�YD�Rc+o��?�q��Ghm��d�S�oh�\�D�|:W������UA�Qc yT�q������~^�H��/��#p�CZ���T�I�1�ӏT����4��"�ČZ�����}��`w�#�*,ʹ�� ��0�i��課�Om�*�da��^gJ݅{���l�e9uF#T�ֲ��̲�ٞC"�q���ߍ ոޑ�o#�XZTp����@ o�8��(jd��xw�]�,f���`~�|,s��^����f�1���t��|��m�򸄭/ctr��5s��7�9Q�4�H1꠲BB@l9@���C�����+�wp�xu�£Yc�9��?`@#�o�mH�s2��)�=��2�.�l����jg�9$�Y�S�%*L������R�Y������7Z���,*=�䷘$�������arm�o�ϰ���UW.|�r�uf����IGw�t����Zwo��~5 ��YյhO+=8fF�)�W�7�L9lM�̘·Y���֘YLf�큹�pRF���99.A �"wz��=E\Z���'a� 2��Ǚ�#;�'}�G���*��l��^"q��+2FQ� hj��kŦ��${���ޮ-�T�٭cf�|�3#~�RJ����t��$b�(R��(����r���dx� >U b�&9,>���%E\� Ά�e�$��'�q't��*�א���ެ�b��-|d���SB�O�O��$�R+�H�)�܎�K��1m`;�J�2�Y~9��O�g8=vqD`K[�F)k�[���1m޼c��n���]s�k�z$@��)!I �x՝"v��9=�ZA=`Ɠi �:�E��)`7��vI��}d�YI�_ �o�:ob���o ���3Q��&D&�2=�� �Ά��;>�h����y.*ⅥS������Ӭ�+q&����j|UƧ����}���J0��WW< ۋS�)jQR�j���Ư��rN)�Gű�4Ѷ(�S)Ǣ�8��i��W52���No˓� ۍ%�5brOn�L�;�n��\G����=�^U�dI���8$�&���h��'���+�(������cȁ߫k�l��S^���cƗjԌE�ꭔ��gF���Ȓ��@���}O���*;e�v�WV���YJ\�]X'5��ղ�k�F��b 6R�o՜m��i N�i����>J����?��lPm�U��}>_Z&�KK��q�r��I�D�Չ~�q�3fL�:S�e>���E���-G���{L�6p�e,8��������QI��h��a�Xa��U�A'���ʂ���s�+טIjP�-��y�8ۈZ?J$��W�P� ��R�s�]��|�l(�ԓ��sƊi��o(��S0��Y� 8�T97.�����WiL��c�~�dxc�E|�2!�X�K�Ƙਫ਼�$((�6�~|d9u+�qd�^3�89��Y�6L�.I�����?���iI�q���9�)O/뚅����O���X��X�V��ZF[�یgQ�L��K1���RҖr@v�#��X�l��F���Нy�S�8�7�kF!A��sM���^rkp�jP�DyS$N���q��nxҍ!U�f�!eh�i�2�m���`�Y�I�9r�6� �TF���C}/�y�^���Η���5d�'��9A-��J��>{�_l+�`��A���[�'��յ�ϛ#w:݅�%��X�}�&�PSt�Q�"�-��\縵�/����$Ɨh�Xb�*�y��BS����;W�ջ_mc�����vt?2}1�;qS�d�d~u:2k5�2�R�~�z+|HE!)�Ǟl��7`��0�<�,�2*���Hl-��x�^����'_TV�gZA�'j� ^�2Ϊ��N7t�����?w�� �x1��f��Iz�C-Ȗ��K�^q�;���-W�DvT�7��8�Z�������� hK�(P:��Q- �8�n�Z���܃e貾�<�1�YT<�,�����"�6{/ �?�͟��|1�:�#g��W�>$����d��J��d�B��=��jf[��%rE^��il:��B���x���Sּ�1հ��,�=��*�7 fcG��#q� �eh?��2�7�����,�!7x��6�n�LC�4x��},Geǝ�tC.��vS �F�43��zz\��;QYC,6����~;RYS/6���|2���5���v��T��i����������mlv��������&� �nRh^ejR�LG�f���? �ۉҬܦƩ��|��Ȱ����>3����!v��i�ʯ�>�v��オ�X3e���_1z�Kȗ\<������!�8���V��]��?b�k41�Re��T�q��mz��TiOʦ�Z��Xq���L������q"+���2ۨ��8}�&N7XU7Ap�d�X��~�׿��&4e�o�F��� �H����O���č�c�� 懴�6���͉��+)��v;j��ݷ�� �UV�� i��� j���Y9GdÒJ1��詞�����V?h��l����l�cGs�ځ�������y�Ac�����\V3�? �� ܙg�>qH�S,�E�W�[�㺨�uch�⍸�O�}���a��>�q�6�n6����N6�q������N ! 1AQaq�0@����"2BRb�#Pr���3C`��Scst���$4D���%Td�� ?���N����a��3��m���C���w��������xA�m�q�m���m������$����4n淿t'��C"w��zU=D�\R+w�p+Y�T�&�պ@��ƃ��3ޯ?�Aﶂ��aŘ���@-�����Q�=���9D��ռ�ѻ@��M�V��P��܅�G5�f�Y<�u=,EC)�<�Fy'�"�&�չ�X~f��l�KԆV��?�� �W�N����=(� �;���{�r����ٌ�Y���h{�١������jW����P���Tc�����X�K�r��}���w�R��%��?���E��m�� �Y�q|����\lEE4���r���}�lsI�Y������f�$�=�d�yO����p�����yBj8jU�o�/�S��?�U��*������ˍ�0������u�q�m [�?f����a�� )Q�>����6#������� ?����0UQ����,IX���(6ڵ[�DI�MNލ�c&���υ�j\��X�R|,4��� j������T�hA�e��^���d���b<����n�� �즇�=!���3�^�`j�h�ȓr��jẕ�c�,ٞX����-����a�ﶔ���#�$��]w�O��Ӫ�1y%��L�Y<�wg#�ǝ�̗`�x�xa�t�w��»1���o7o5��>�m뭛C���Uƃߜ}�C���y1Xνm�F8�jI���]����H���ۺиE@I�i;r�8ӭ����V�F�Շ| ��&?�3|x�B�MuS�Ge�=Ӕ�#BE5G�����Y!z��_e��q�р/W>|-�Ci߇�t�1ޯќd�R3�u��g�=0 5��[?�#͏��q�cf���H��{ ?u�=?�?ǯ���}Z��z���hmΔ�BFTW�����<�q�(v� ��!��z���iW]*�J�V�z��gX֧A�q�&��/w���u�gYӘa���; �i=����g:��?2�dž6�ى�k�4�>�Pxs����}������G�9��3 ���)gG�R<>r h�$��'nc�h�P��Bj��J�ҧH� -��N1���N��?��~��}-q!=��_2hc�M��l�vY%UE�@|�v����M2�.Y[|y�"Eï��K�ZF,�ɯ?,q�?v�M 80jx�"�;�9vk�����+ ֧�� �ȺU��?�%�vcV��mA�6��Qg^M����A}�3�nl� QRN�l8�kkn�'�����(��M�7m9و�q���%ޟ���*h$Zk"��$�9��: �?U8�Sl��,,|ɒ��xH(ѷ����Gn�/Q�4�P��G�%��Ա8�N��!� �&�7�;���eKM7�4��9R/%����l�c>�x;������>��C�:�����t��h?aKX�bhe�ᜋ^�$�Iհ �hr7%F$�E��Fd���t��5���+�(M6�t����Ü�UU|zW�=a�Ts�Tg������dqP�Q����b'�m���1{|Y����X�N��b �P~��F^F:����k6�"�j!�� �I�r�`��1&�-$�Bevk:y���#yw��I0��x��=D�4��tU���P�ZH��ڠ底taP��6����b>�xa����Q�#� WeF��ŮNj�p�J* mQ�N����*I�-*�ȩ�F�g�3 �5��V�ʊ�ɮ�a��5F���O@{���NX��?����H�]3��1�Ri_u��������ѕ�� ����0��� F��~��:60�p�͈�S��qX#a�5>���`�o&+�<2�D����: �������ڝ�$�nP���*)�N�|y�Ej�F�5ټ�e���ihy�Z �>���k�bH�a�v��h�-#���!�Po=@k̆IEN��@��}Ll?j�O������߭�ʞ���Q|A07x���wt!xf���I2?Z��<ץ�T���cU�j��]��陎Ltl �}5�ϓ��$�,��O�mˊ�;�@O��jE��j(�ا,��LX���LO���Ц�90�O �.����a��nA���7������j4 ��W��_ٓ���zW�jcB������y՗+EM�)d���N�g6�y1_x��p�$Lv:��9�"z��p���ʙ$��^��JԼ*�ϭ����o���=x�Lj�6�J��u82�A�H�3$�ٕ@�=Vv�]�'�qEz�;I˼��)��=��ɯ���x �/�W(V���p�����$ �m�������u�����񶤑Oqˎ�T����r��㠚x�sr�GC��byp�G��1ߠ�w e�8�$⿄����/�M{*}��W�]˷.�CK\�ުx���/$�WPw���r� |i���&�}�{�X� �>��$-��l���?-z���g����lΆ���(F���h�vS*���b���߲ڡn,|)mrH[���a�3�ר�[1��3o_�U�3�TC�$��(�=�)0�kgP���� ��u�^=��4 �WYCҸ:��vQ�ר�X�à��tk�m,�t*��^�,�}D*� �"(�I��9R����>`�`��[~Q]�#af��i6l��8���6�:,s�s�N6�j"�A4���IuQ��6E,�GnH��zS�HO�uk�5$�I�4��ؤ�Q9�@��C����wp�BGv[]�u�Ov���0I4���\��y�����Q�Ѹ��~>Z��8�T��a��q�ޣ;z��a���/��S��I:�ܫ_�|������>=Z����8:�S��U�I�J��"IY���8%b8���H��:�QO�6�;7�I�S��J��ҌAά3��>c���E+&jf$eC+�z�;��V����� �r���ʺ������my�e���aQ�f&��6�ND��.:��NT�vm�<- u���ǝ\MvZY�N�NT��-A�>jr!S��n�O 1�3�Ns�%�3D@���`������ܟ 1�^c<���� �a�ɽ�̲�Xë#�w�|y�cW�=�9I*H8�p�^(4���՗�k��arOcW�tO�\�ƍR��8����'�K���I�Q�����?5�>[�}��yU�ײ -h��=��% q�ThG�2�)���"ו3]�!kB��*p�FDl�A���,�eEi�H�f�Ps�����5�H:�Փ~�H�0Dت�D�I����h�F3�������c��2���E��9�H��5�zԑ�ʚ�i�X�=:m�xg�hd(�v����׊�9iS��O��d@0ڽ���:�p�5�h-��t�&���X�q�ӕ,��ie�|���7A�2���O%P��E��htj��Y1��w�Ѓ!����  ���� ࢽ��My�7�\�a�@�ţ�J �4�Ȼ�F�@o�̒?4�wx��)��]�P��~�����u�����5�����7X ��9��^ܩ�U;Iꭆ 5 �������eK2�7(�{|��Y׎ �V��\"���Z�1� Z�����}��(�Ǝ"�1S���_�vE30>���p;� ΝD��%x�W�?W?v����o�^V�i�d��r[��/&>�~`�9Wh��y�;���R��� ;;ɮT��?����r$�g1�K����A��C��c��K��l:�'��3 c�ﳯ*"t8�~l��)���m��+U,z��`(�>yJ�?����h>��]��v��ЍG*�{`��;y]��I�T� ;c��NU�fo¾h���/$���|NS���1�S�"�H��V���T���4��uhǜ�]�v;���5�͠x��'C\�SBpl���h}�N����� A�Bx���%��ޭ�l��/����T��w�ʽ]D�=����K���ž�r㻠l4�S�O?=�k �M:� ��c�C�a�#ha���)�ѐxc�s���gP�iG��{+���x���Q���I= �� z��ԫ+ �8"�k�ñ�j=|����c ��y��CF��/��*9ж�h{ �?4�o� ��k�m�Q�N�x��;�Y��4膚�a�w?�6�>e]�����Q�r�:����g�,i"�����ԩA�*M�<�G��b�if��l^M��5� �Ҩ�{����6J��ZJ�����P�*�����Y���ݛu�_4�9�I8�7���������,^ToR���m4�H��?�N�S�ѕw��/S��甍�@�9H�S�T��t�ƻ���ʒU��*{Xs�@����f�����֒Li�K{H�w^���������Ϥm�tq���s� ���ք��f:��o~s��g�r��ט� �S�ѱC�e]�x���a��) ���(b-$(�j>�7q�B?ӕ�F��hV25r[7 Y� }L�R��}����*sg+��x�r�2�U=�*'WS��ZDW]�WǞ�<��叓���{�$�9Ou4��y�90-�1�'*D`�c�^o?(�9��u���ݐ��'PI&� f�Jݮ�������:wS����jfP1F:X �H�9dԯ���˝[�_54 �}*;@�ܨ�� ð�yn�T���?�ןd�#���4rG�ͨ��H�1�|-#���Mr�S3��G�3�����)�.᧏3v�z֑��r����$G"�`j �1t��x0<Ɔ�Wh6�y�6��,œ�Ga��gA����y��b��)��h�D��ß�_�m��ü �gG;��e�v��ݝ�nQ� ��C����-�*��o���y�a��M��I�>�<���]obD��"�:���G�A��-\%LT�8���c�)��+y76���o�Q�#*{�(F�⽕�y����=���rW�\p���۩�c���A���^e6��K������ʐ�cVf5$�'->���ՉN"���F�"�UQ@�f��Gb~��#�&�M=��8�ט�JNu9��D��[̤�s�o�~������ G��9T�tW^g5y$b��Y'��س�Ǵ�=��U-2 #�MC�t(�i� �lj�@Q 5�̣i�*�O����s�x�K�f��}\��M{E�V�{�υ��Ƈ�����);�H����I��fe�Lȣr�2��>��W�I�Ȃ6������i��k�� �5�YOxȺ����>��Y�f5'��|��H+��98pj�n�.O�y�������jY��~��i�w'������l�;�s�2��Y��:'lg�ꥴ)o#'Sa�a�K��Z� �m��}�`169�n���"���x��I ��*+� }F<��cГ���F�P�������ֹ*�PqX�x۩��,� ��N�� �4<-����%����:��7����W���u�`����� $�?�I��&����o��o��`v�>��P��"��l���4��5'�Z�gE���8���?��[�X�7(��.Q�-��*���ތL@̲����v��.5���[��=�t\+�CNܛ��,g�SQnH����}*F�G16���&:�t��4ُ"A��̣��$�b �|����#rs��a�����T�� ]�<�j��BS�('$�ɻ� �wP;�/�n��?�ݜ��x�F��yUn�~mL*-�������Xf�wd^�a�}��f�,=t�׵i�.2/wpN�Ep8�OР���•��R�FJ� 55TZ��T �ɭ�<��]��/�0�r�@�f��V��V����Nz�G��^���7hZi����k��3�,kN�e|�vg�1{9]_i��X5y7� 8e]�U����'�-2,���e"����]ot�I��Y_��n�(JҼ��1�O ]bXc���Nu�No��pS���Q_���_�?i�~�x h5d'�(qw52] ��'ޤ�q��o1�R!���`ywy�A4u���h<קy���\[~�4�\ X�Wt/� 6�����n�F�a8��f���z �3$�t(���q��q�x��^�XWeN'p<-v�!�{�(>ӽDP7��ո0�y)�e$ٕv�Ih'Q�EA�m*�H��RI��=:��� ���4牢) �%_iN�ݧ�l]� �Nt���G��H�L��� ɱ�g<���1V�,�J~�ٹ�"K��Q�� 9�HS�9�?@��k����r�;we݁�]I�!{ �@�G�[�"��`���J:�n]�{�cA�E����V��ʆ���#��U9�6����j�#Y�m\��q�e4h�B�7��C�������d<�?J����1g:ٳ���=Y���D�p�ц� ׈ǔ��1�]26؜oS�'��9�V�FVu�P�h�9�xc�oq�X��p�o�5��Ա5$�9W�V(�[Ak�aY錎qf;�'�[�|���b�6�Ck��)��#a#a˙��8���=äh�4��2��C��4tm^ �n'c���]GQ$[Wҿ��i���vN�{Fu ��1�gx��1┷���N�m��{j-,��x�� Ūm�ЧS�[�s���Gna���䑴�� x�p 8<������97�Q���ϴ�v�aϚG��Rt�Һ׈�f^\r��WH�JU�7Z���y)�vg=����n��4�_)y��D'y�6�]�c�5̪�\� �PF�k����&�c;��cq�$~T�7j ���nç]�<�g ":�to�t}�159�<�/�8������m�b�K#g'I'.W�����6��I/��>v��\�MN��g���m�A�yQL�4u�Lj�j9��#44�t��l^�}L����n��R��!��t��±]��r��h6ٍ>�yҏ�N��fU�� ���� Fm@�8}�/u��jb9������he:A�y�ծw��GpΧh�5����l}�3p468��)U��d��c����;Us/�֔�YX�1�O2��uq�s��`hwg�r~�{ R��mhN��؎*q 42�*th��>�#���E����#��Hv�O����q�}�����6�e��\�,Wk�#���X��b>��p}�դ��3���T5��†��6��[��@�P�y*n��|'f�֧>�lư΂�̺����SU�'*�q�p�_S�����M�� '��c�6�����m�� ySʨ;M��r���Ƌ�m�Kxo,���Gm�P��A�G�:��i��w�9�}M(�^�V��$ǒ�ѽ�9���|���� �a����J�SQ�a���r�B;����}���ٻ֢�2�%U���c�#�g���N�a�ݕ�'�v�[�OY'��3L�3�;,p�]@�S��{ls��X�'���c�jw�k'a�.��}�}&�� �dP�*�bK=ɍ!����;3n�gΊU�ߴmt�'*{,=SzfD� A��ko~�G�aoq�_mi}#�m�������P�Xhύ����mxǍ�΂���巿zf��Q���c���|kc�����?���W��Y�$���_Lv����l߶��c���`?����l�j�ݲˏ!V��6����U�Ђ(A���4y)H���p�Z_�x��>���e��R��$�/�`^'3qˏ�-&Q�=?��CFVR �D�fV�9��{�8g�������n�h�(P"��6�[�D���< E�����~0<@�`�G�6����Hг�cc�� �c�K.5��D��d�B���`?�XQ��2��ٿyqo&+�1^� DW�0�ꊩ���G�#��Q�nL3��c���������/��x ��1�1[y�x�პCW��C�c�UĨ80�m�e�4.{�m��u���I=��f�����0QRls9���f���������9���~f�����Ǩ��a�"@�8���ȁ�Q����#c�ic������G��$���G���r/$W�(��W���V�"��m�7�[m�A�m����bo��D� j����۳� l���^�k�h׽����� ��#� iXn�v��eT�k�a�^Y�4�BN��ĕ��0 !01@Q"2AaPq3BR������?���@4�Q�����T3,���㺠�W�[=JK�Ϟ���2�r^7��vc�:�9 �E�ߴ�w�S#d���Ix��u��:��Hp��9E!�� V 2;73|F��9Y���*ʬ�F��D����u&���y؟��^EA��A��(ɩ���^��GV:ݜDy�`��Jr29ܾ�㝉��[���E;Fzx��YG��U�e�Y�C���� ����v-tx����I�sם�Ę�q��Eb�+P\ :>�i�C'�;�����k|z�رn�y]�#ǿb��Q��������w�����(�r|ӹs��[�D��2v-%��@;�8<a���[\o[ϧw��I!��*0�krs)�[�J9^��ʜ��p1)� "��/_>��o��<1����A�E�y^�C��`�x1'ܣn�p��s`l���fQ��):�l����b>�Me�jH^?�kl3(�z:���1ŠK&?Q�~�{�ٺ�h�y���/�[��V�|6��}�KbX����mn[-��7�5q�94�������dm���c^���h� X��5��<�eޘ>G���-�}�دB�ޟ� ��|�rt�M��V+�]�c?�-#ڛ��^ǂ}���Lkr���O��u�>�-D�ry� D?:ޞ�U��ǜ�7�V��?瓮�"�#���r��չģVR;�n���/_� ؉v�ݶe5d�b9��/O��009�G���5n�W����JpA�*�r9�>�1��.[t���s�F���nQ� V 77R�]�ɫ8����_0<՜�IF�u(v��4��F�k�3��E)��N:��yڮe��P�`�1}�$WS��J�SQ�N�j�ٺ��޵�#l���ј(�5=��5�lǏmoW�v-�1����v,W�mn��߀$x�<����v�j(����c]��@#��1������Ǔ���o'��u+����;G�#�޸��v-lη��/(`i⣍Pm^���ԯ̾9Z��F��������n��1��� ��]�[��)�'������:�֪�W��FC����� �B9،!?���]��V��A�Վ�M��b�w��G F>_DȬ0¤�#�QR�[V��kz���m�w�"��9ZG�7'[��=�Q����j8R?�zf�\a�=��O�U����*oB�A�|G���2�54 �p��.w7� �� ��&������ξxGHp� B%��$g�����t�Џ򤵍z���HN�u�Я�-�'4��0��;_��3 !01"@AQa2Pq#3BR������?��ʩca��en��^��8���<�u#��m*08r��y�N"�<�Ѳ0��@\�p��� �����Kv�D��J8�Fҽ� �f�Y��-m�ybX�NP����}�!*8t(�OqѢ��Q�wW�K��ZD��Δ^e��!� ��B�K��p~�����e*l}z#9ң�k���q#�Ft�o��S�R����-�w�!�S���Ӥß|M�l޶V��!eˈ�8Y���c�ЮM2��tk���� ������J�fS����Ö*i/2�����n]�k�\���|4yX�8��U�P.���Ы[���l��@"�t�<������5�lF���vU�����W��W��;�b�cД^6[#7@vU�xgZv��F�6��Q,K�v��� �+Ъ��n��Ǣ��Ft���8��0��c�@�!�Zq s�v�t�;#](B��-�nῃ~���3g������5�J�%���O������n�kB�ĺ�.r��+���#�N$?�q�/�s�6��p��a����a��J/��M�8��6�ܰ"�*������ɗud"\w���aT(����[��F��U՛����RT�b���n�*��6���O��SJ�.�ij<�v�MT��R\c��5l�sZB>F��<7�;EA��{��E���Ö��1U/�#��d1�a�n.1ě����0�ʾR�h��|�R��Ao�3�m3 ��%�� ���28Q� ��y��φ���H�To�7�lW>����#i`�q���c����a��� �m,B�-j����݋�'mR1Ήt�>��V��p���s�0IbI�C.���1R�ea�����]H�6����������4B>��o��](��$B���m�����a�!=��?�B� K�Ǿ+�Ծ"�n���K��*��+��[T#�{E�J�S����Q�����s�5�:�U�\wĐ�f�3����܆&�)����I���Ԇw��E T�lrTf6Q|R�h:��[K�� �z��c֧�G�C��%\��_�a�84��HcO�bi��ؖV��7H �)*ģK~Xhչ0��4?�0��� �E<���}3���#���u�?�� ��|g�S�6ꊤ�|�I#Hڛ� �ա��w�X��9��7���Ŀ%�SL��y6č��|�F�a 8���b��$�sק�h���b9RAu7�˨p�Č�_\*w��묦��F ����4D~�f����|(�"m���NK��i�S�>�$d7SlA��/�²����SL��|6N�}���S�˯���g��]6��; �#�.��<���q'Q�1|KQ$�����񛩶"�$r�b:���N8�w@��8$�� �AjfG|~�9F ���Y��ʺ��Bwؒ������M:I岎�G��`s�YV5����6��A �b:�W���G�q%l�����F��H���7�������Fsv7��k�� 403WebShell
403Webshell
Server IP : 104.21.45.146  /  Your IP : 172.69.214.108
Web Server : Apache/2.4.52 (Ubuntu)
System : Linux ip-172-31-19-221 6.8.0-1029-aws #31~22.04.1-Ubuntu SMP Thu Apr 24 21:16:18 UTC 2025 x86_64
User : www-data ( 33)
PHP Version : 8.1.28
Disable Function : NONE
MySQL : OFF  |  cURL : ON  |  WGET : ON  |  Perl : ON  |  Python : OFF  |  Sudo : ON  |  Pkexec : ON
Directory :  /efsdata/scitechnol.com/httpdocs/submission/uploads/

Upload File :
current_dir [ Writeable ] document_root [ Writeable ]

 

Command :


[ Back ]     

Current File : /efsdata/scitechnol.com/httpdocs/submission/uploads/399-0-Manuscript-2013-03-11.doc
��ࡱ�>��	wy����rstuv���������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������{�	�� �bjbjz�z�	;����,���������44444����HHH8��,LHL8&x�222!�
 4A!��7�7�7�7�7�7�7r:�$=6�74�!!!�!�!�74422�85'5'5'�!�4242!.�	5'�!�75'5':=,,�,2���� 
K�������#bi,

.80L8s,RZ=&$Z=�,�,Z=4�,4�!�!5'�!�!�!�!�!�7�75'�!�!�!L8�!�!�!�!��������������������������������������������������������������������Z=�!�!�!�!�!�!�!�!�!� �:	Dear Internaional Journal of Ophthalmic Pathology,

Please find our original manuscript, �Detection of diabetic retinal neuropathy using standard clinical electrodiagnostic testing�, below for submission. We believe the topic of this manuscript is well suited your journal and hope you find it a valuable submission.

There are no conflicts of interest to disclose for any author on this manuscript. Please let us know if you have any questions. We look forward to hearing status updates as this submission makes its way through your peer-review process.

Jason S. Ng
Corresponding author




























Detection of diabetic retinal neuropathy using standard clinical electrodiagnostic testing

Running title: Clinical detection of diabetic retinal neuropathy

Jason S. Ng, Taylor Chin, Melissa Vydelingum, Robert Yacoub, Christy Guenther
Southern California College of Optometry

Corresponding Author:
Jason S. Ng, OD, PhD, FAAO
Southern California College of Optometry
2575 Yorba Linda BLVD
Fullerton, CA 92831
714-992-7880
 HYPERLINK "mailto:jng@scco.edu" jng@scco.edu

Conflicts of Interest: None

Abstract Word Count: 249
Manuscript Word Count: 2135
	




















Abstract

Background: Several basic science studies have shown that retinal neural function is abnormal in diabetes. The basic research has not translated clinically to earlier integration of investigating the neural dysfunctions however, possibly due to non-standard recording protocols and/or complex data analysis. We investigated whether neural dysfunction would be found using standard clinical methods of patient testing and analysis.
Methods: Forty-five subjects (27 controls / 18 diabetics) participated in the study. There was no difference in the subjects� (mean�SD) ages (controls: 49.5 � 9.1 yrs., diabetics: 52.4 � 8.5 yrs., p = 0.28). All subjects were free from ocular pathologies except for minimal diabetic retinopathy. Subjects had comprehensive eye evaluations, including retinal photography and standard clinical multifocal electrogram (mfERG) recordings. The data collected from one random eye of each subject was analyzed. The implicit time and amplitudes of the mfERG were analyzed by examining the total average response of all areas tested and the response of the macula.
Results: Significant increases in implicit time were found for subjects with diabetes in the total area examined (p = 0.002) as well as the macular area (p < 0.001) as compared to controls. No significant decreases were observed for amplitudes in the total area examined (p = 0.57) or in the macular area (p = 0.46). 
Conclusions: Significant (generalized and macular) retinal neural dysfunction can be observed using standard clinical techniques even in patients with minimal diabetic retinopathy. These findings should encourage clinicians to consider evaluating this aspect of diabetic retinal neuropathy.  
Keywords: diabetic retinopathy, electroretinography, diabetes, diabetic neuropathy, electroretinogram
Introduction
	 The worldwide prevalence of diabetes continues to increase and poses a continued threat to health resources. ADDIN EN.CITE  ADDIN EN.CITE.DATA  HYPERLINK \l "_ENREF_1" \o "Wild, 2004 #682" 1,  HYPERLINK \l "_ENREF_2" \o "Whiting, 2011 #681" 2 As a result of increased urbanization, population growth, and the prevalence of obesity and sedentary lifestyles, an estimated 552 million individuals worldwide will be affected by diabetes by 2030. ADDIN EN.CITE  ADDIN EN.CITE.DATA  HYPERLINK \l "_ENREF_1" \o "Wild, 2004 #682" 1,  HYPERLINK \l "_ENREF_2" \o "Whiting, 2011 #681" 2 The U.S. prevalence is expected to increase from an estimated 23.7 million in 2011 to 29.6 million in 2030. HYPERLINK \l "_ENREF_2" \o "Whiting, 2011 #681"  ADDIN EN.CITE <EndNote><Cite><Author>Whiting</Author><Year>2011</Year><RecNum>681</RecNum><DisplayText><style face="superscript" font="Times New Roman">2</style></DisplayText><record><rec-number>681</rec-number><foreign-keys><key app="EN" db-id="e5tfs5v2rp5r0ge9sscvwr0msavadprtrf2t">681</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Whiting, D. R.</author><author>Guariguata, L.</author><author>Weil, C.</author><author>Shaw, J.</author></authors></contributors><auth-address>International Diabetes Federation, Brussels, Belgium. david@davidwhiting.me.uk</auth-address><titles><title>IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030</title><secondary-title>Diabetes Res Clin Pract</secondary-title><alt-title>Diabetes research and clinical practice</alt-title></titles><periodical><full-title>Diabetes Res Clin Pract</full-title><abbr-1>Diabetes research and clinical practice</abbr-1></periodical><alt-periodical><full-title>Diabetes Res Clin Pract</full-title><abbr-1>Diabetes research and clinical practice</abbr-1></alt-periodical><pages>311-21</pages><volume>94</volume><number>3</number><edition>2011/11/15</edition><keywords><keyword>Diabetes Mellitus/*epidemiology</keyword><keyword>Humans</keyword><keyword>Models, Statistical</keyword><keyword>Prevalence</keyword><keyword>Time Factors</keyword><keyword>*World Health</keyword><keyword>World Health Organization</keyword></keywords><dates><year>2011</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>1872-8227 (Electronic)&#xD;0168-8227 (Linking)</isbn><accession-num>22079683</accession-num><work-type>Research Support, Non-U.S. Gov&apos;t</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/22079683</url></related-urls></urls><electronic-resource-num>10.1016/j.diabres.2011.10.029</electronic-resource-num><language>eng</language></record></Cite></EndNote>2  
Diabetes can lead to many systemic complications that include the nervous and renal systems. It affects 8.3% of the United States population and is the leading cause of kidney failure as well as non-traumatic lower-limb amputations in the nation. HYPERLINK \l "_ENREF_3" \o ", 2011 #697"  ADDIN EN.CITE <EndNote><Cite><Year>2011</Year><RecNum>697</RecNum><DisplayText><style face="superscript" font="Times New Roman">3</style></DisplayText><record><rec-number>697</rec-number><foreign-keys><key app="EN" db-id="e5tfs5v2rp5r0ge9sscvwr0msavadprtrf2t">697</key></foreign-keys><ref-type name="Pamphlet">24</ref-type><contributors><secondary-authors><author>Centers for Disease Control and Prevention</author></secondary-authors></contributors><titles><title>National diabetes fact sheet: national estimates and general information on diabetes and prediabetes in the United States, 2011</title></titles><dates><year>2011</year></dates><pub-location>Atlanta, GA</pub-location><publisher>U.S. Department of Health and Human Services</publisher><urls></urls></record></Cite></EndNote>3 The vision of individuals with diabetes may be affected psychophysically, as noted with changes in dark adaptation, contrast sensitivity, glare recovery, color vision, and visual acuity. HYPERLINK \l "_ENREF_4" \o "Brinchmann-Hansen, 1992 #1648"  ADDIN EN.CITE  ADDIN EN.CITE.DATA 4-11 HYPERLINK \l "_ENREF_4" \o "Frost-Larsen, 1991 #1643"  HYPERLINK \l "_ENREF_4" \o "Yamazaki, 1982 #1650"  HYPERLINK \l "_ENREF_4" \o "Greenstein, 1990 #443"  HYPERLINK \l "_ENREF_4" \o "Adams, 2012 #684"  The primary ocular complication of diabetes is diabetic retinopathy�one of the leading causes of blindness in American adults. HYPERLINK \l "_ENREF_12" \o "Kempen, 2003 #696"  ADDIN EN.CITE <EndNote><Cite><Author>Kempen</Author><Year>2003</Year><RecNum>696</RecNum><DisplayText><style face="superscript" font="Times New Roman">12</style></DisplayText><record><rec-number>696</rec-number><foreign-keys><key app="EN" db-id="e5tfs5v2rp5r0ge9sscvwr0msavadprtrf2t">696</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kempen, J. H.</author></authors></contributors><titles><title>The Prevalence of Diabetic Retinopathy Among Adults in the United States</title><secondary-title>Archives of Ophthalmology</secondary-title></titles><periodical><full-title>Arch Ophthalmol</full-title><abbr-1>Archives of ophthalmology</abbr-1></periodical><pages>552-563</pages><volume>122</volume><number>4</number><dates><year>2003</year></dates><urls></urls></record></Cite></EndNote>12 It can result in several ocular findings including microaneurysms, dot/blot hemorrhages, soft and hard exudates, macular edema, and neovascularization. HYPERLINK \l "_ENREF_13" \o "Fong, 2003 #685"  ADDIN EN.CITE <EndNote><Cite><Author>Fong</Author><Year>2003</Year><RecNum>685</RecNum><DisplayText><style face="superscript" font="Times New Roman">13</style></DisplayText><record><rec-number>685</rec-number><foreign-keys><key app="EN" db-id="e5tfs5v2rp5r0ge9sscvwr0msavadprtrf2t">685</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Fong, D. S.</author><author>Aiello, L.</author><author>Gardner, T. W.</author><author>King, G. L.</author><author>Blankenship, G.</author><author>Cavallerano, J. D.</author><author>Ferris, F. L., 3rd</author><author>Klein, R.</author></authors></contributors><titles><title>Diabetic retinopathy</title><secondary-title>Diabetes Care</secondary-title><alt-title>Diabetes care</alt-title></titles><periodical><full-title>Diabetes Care</full-title><abbr-1>Diabetes care</abbr-1></periodical><alt-periodical><full-title>Diabetes Care</full-title><abbr-1>Diabetes care</abbr-1></alt-periodical><pages>226-9</pages><volume>26</volume><number>1</number><edition>2002/12/28</edition><keywords><keyword>Diabetic Retinopathy/*epidemiology/*therapy</keyword><keyword>Humans</keyword><keyword>Practice Guidelines as Topic</keyword><keyword>Risk Factors</keyword></keywords><dates><year>2003</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>0149-5992 (Print)&#xD;0149-5992 (Linking)</isbn><accession-num>12502685</accession-num><work-type>Review</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/12502685</url></related-urls></urls><language>eng</language></record></Cite></EndNote>13
Long-standing interventions for diabetic retinopathy include improved control of blood pressure and blood sugar levels, laser photocoagulation (pan-retinal and focal/grid), and vitrectomy; the latter two being specific ocular treatments used for severe stages. HYPERLINK \l "_ENREF_14" \o "Mohamed, 2007 #881"  ADDIN EN.CITE <EndNote><Cite><Author>Mohamed</Author><Year>2007</Year><RecNum>881</RecNum><DisplayText><style face="superscript" font="Times New Roman">14</style></DisplayText><record><rec-number>881</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">881</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Mohamed, Q.</author><author>Gillies, M. C.</author><author>Wong, T. Y.</author></authors></contributors><auth-address>Centre for Eye Research Australia, University of Melbourne and Royal Victorian Eye and Ear Hospital, Melbourne, Australia.</auth-address><titles><title>Management of diabetic retinopathy: a systematic review</title><secondary-title>Jama</secondary-title></titles><periodical><full-title>JAMA</full-title></periodical><pages>902-16</pages><volume>298</volume><number>8</number><keywords><keyword>Angiogenesis Inhibitors/therapeutic use</keyword><keyword>Antihypertensive Agents/therapeutic use</keyword><keyword>Antilipemic Agents/therapeutic use</keyword><keyword>Blood Glucose</keyword><keyword>Blood Pressure</keyword><keyword>Diabetic Retinopathy/prevention &amp; control/*therapy</keyword><keyword>Glucocorticoids/therapeutic use</keyword><keyword>Humans</keyword><keyword>Laser Coagulation</keyword><keyword>Light Coagulation</keyword><keyword>Macular Edema/therapy</keyword><keyword>Vitrectomy</keyword></keywords><dates><year>2007</year><pub-dates><date>Aug 22</date></pub-dates></dates><isbn>1538-3598 (Electronic)</isbn><accession-num>17712074</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=17712074 </url></related-urls></urls><language>eng</language></record></Cite></EndNote>14 More recent therapies have involved corticosteroids or drugs that bind vascular endothelial growth factor (VEGF) to reduce angiogenic factors. HYPERLINK \l "_ENREF_13" \o "Fong, 2003 #685"  ADDIN EN.CITE  ADDIN EN.CITE.DATA 13-16 Systemic interventions (i.e. blood pressure and blood sugar control) are essentially safe and without complication, but the ocular interventions can have many unwanted side effects even when done perfectly: loss of peripheral vision, reduction in night vision, induction of cataracts, and increased intraocular pressure. ADDIN EN.CITE  ADDIN EN.CITE.DATA  HYPERLINK \l "_ENREF_17" \o "Bressler, 2011 #1584" 17,  HYPERLINK \l "_ENREF_18" \o "Krepler, 2005 #703" 18 Additionally, newer ocular treatments are not always effective and often require repeated treatments. HYPERLINK \l "_ENREF_19" \o "Mitchell, 2012 #1585"  ADDIN EN.CITE  ADDIN EN.CITE.DATA 19 Thus, from a public health standpoint, diabetic retinopathy needs to be diagnosed earlier and newer treatments must be developed that can be given earlier and without unwanted complications or side effects. In order to accomplish these goals, earlier measures of retinal dysfunction must be available to researchers and clinicians alike.
Current methods of diagnosing diabetic retinopathy arguably cannot be relied upon to identify the earliest signs of retinal dysfunction. The primary outcome measure for the US Food and Drug Administration when evaluating ocular therapies for eye disease is visual acuity loss, which occurs once the disease has progressed significantly. HYPERLINK \l "_ENREF_11" \o "Adams, 2012 #684"  ADDIN EN.CITE  ADDIN EN.CITE.DATA 11 The Early Treatment Diabetic Retinopathy Study (ETDRS) developed a scale used to grade the severity of diabetic retinopathy in fundus photographs. HYPERLINK \l "_ENREF_20" \o "Kono, 2005 #691"  ADDIN EN.CITE <EndNote><Cite><RecNum>691</RecNum><DisplayText><style face="superscript" font="Times New Roman">20</style></DisplayText><record><rec-number>691</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">691</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kono, T.</author><author>Shiga, S.</author><author>Takesue, Y.</author><author>Sakamoto, T.</author></authors></contributors><auth-address>Department of Ophthalmology, Fukuoka University Chikushi Hospital, Japan.</auth-address><titles><title>Long-term results of pars plana vitrectomy combined with filtering surgery for neovascular glaucoma</title><secondary-title>Ophthalmic Surg Lasers Imaging</secondary-title></titles><periodical><full-title>Ophthalmic Surg Lasers Imaging</full-title></periodical><pages>211-6</pages><volume>36</volume><number>3</number><keywords><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Ciliary Body/surgery</keyword><keyword>Diabetic Retinopathy/complications</keyword><keyword>Female</keyword><keyword>Filtering Surgery/*methods</keyword><keyword>Follow-Up Studies</keyword><keyword>Glaucoma, Neovascular/etiology/*surgery</keyword><keyword>Humans</keyword><keyword>Intraocular Pressure</keyword><keyword>Laser Coagulation</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Retinal Vein Occlusion/complications</keyword><keyword>Retrospective Studies</keyword><keyword>Treatment Outcome</keyword><keyword>Visual Acuity</keyword><keyword>Vitrectomy/*methods</keyword></keywords><dates><year>2005</year><pub-dates><date>May-Jun</date></pub-dates></dates><accession-num>15957478</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=15957478</url></related-urls></urls></record></Cite></EndNote>20 The ETDRS final retinopathy severity scale contains 13 unique steps that are defined by a level. However, the scale was developed decades ago when the main concern was severe visual impairment or blindness and the treatment options at that time were extremely limited. Clinically diabetic retinopathy is diagnosed based on a relatively coarse staging of pathology, from mild non-proliferative diabetic retinopathy (microaneurysms only) to high-risk proliferative diabetic retinopathy (characterized by substantial neovascularization). Patients can progress through the clinical stages at various rates or even present clinically already at the end-stage, primarily because visual acuity can remain robust even in the presence of proliferative disease. 
Recent studies have discussed a potential method of early assessment that focuses on neural changes of the retina instead of vascular, clinically visible changes. ADDIN EN.CITE  ADDIN EN.CITE.DATA  HYPERLINK \l "_ENREF_11" \o "Adams, 2012 #684" 11,  HYPERLINK \l "_ENREF_21" \o "Harrison, 2011 #1599" 21 Using a clinical electrodiagnostic test known as the multifocal electroretinogram (mfERG), areas of abnormal retinal neural function can be detected even before clinically visible changes in the vasculature. HYPERLINK \l "_ENREF_22" \o "Kondo, 1995 #685"  ADDIN EN.CITE <EndNote><Cite><Author>Kondo</Author><Year>1995</Year><RecNum>685</RecNum><DisplayText><style face="superscript" font="Times New Roman">22</style></DisplayText><record><rec-number>685</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">685</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kondo, M.</author><author>Miyake, Y.</author><author>Horiguchi, M.</author><author>Suzuki, S.</author><author>Tanikawa, A.</author></authors></contributors><auth-address>Department of Ophthalmology, Nagoya University School of Medicine, Japan.</auth-address><titles><title>Clinical evaluation of multifocal electroretinogram</title><secondary-title>Invest Ophthalmol Vis Sci</secondary-title></titles><periodical><full-title>Invest Ophthalmol Vis Sci</full-title></periodical><pages>2146-50</pages><volume>36</volume><number>10</number><keywords><keyword>Adult</keyword><keyword>Comparative Study</keyword><keyword>Electroretinography/methods</keyword><keyword>Evaluation Studies</keyword><keyword>Female</keyword><keyword>Human</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Perimetry</keyword><keyword>Retina/*physiology</keyword><keyword>Retinal Artery Occlusion/*physiopathology</keyword><keyword>Retinal Degeneration/*physiopathology</keyword><keyword>Retinal Perforations/*physiopathology</keyword><keyword>Retinitis Pigmentosa/*physiopathology</keyword><keyword>Visual Fields</keyword></keywords><dates><year>1995</year><pub-dates><date>Sep</date></pub-dates></dates><accession-num>7657552</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=7657552</url></related-urls></urls></record></Cite></EndNote>22 The test provides an objective evaluation of retinal function and only takes 10-15 minutes of data recording time. Multifocal electroretinograms generate a great deal of raw data (i.e. ~100 areas tested in the central 50 degrees of the retina, Fig. 1). For each small area tested, at least two measures (an amplitude and an implicit time) can be derived for each of three parts of the standard waveform. The parts of the waveforms are known as N1, P1, and N2, specifying the 1st negative trough, 1st positive peak, and the 2nd negative trough (Fig. 2). The cellular generator of the N1 component is primarily attributed to the photoreceptors and the P1 component is primarily attributed to the bipolar cells. HYPERLINK \l "_ENREF_23" \o "Hood, 2002 #538"  ADDIN EN.CITE  ADDIN EN.CITE.DATA 23 Of these, P1 of the standard flash multifocal electrogram has been the most studied in diabetes. Specifically, increases in the P1 implicit time (aka �delays�) have been shown to be associated with and even predictive of non-proliferative diabetic retinopathy lesions, including edema. ADDIN EN.CITE  ADDIN EN.CITE.DATA  HYPERLINK \l "_ENREF_24" \o "Fortune, 1999 #378" 24,  HYPERLINK \l "_ENREF_25" \o "Bearse, 2006 #1625" 25 Decreases in the P1 amplitude have been found to be associated with and partly predictive of edema in the macular area, but not for other lesion types. ADDIN EN.CITE  ADDIN EN.CITE.DATA  HYPERLINK \l "_ENREF_21" \o "Harrison, 2011 #1599" 21,  HYPERLINK \l "_ENREF_25" \o "Bearse, 2006 #1625" 25 

Figure 1. Standard (103 hexagon) multifocal electroretinogram stimulus array, testing approximately the central 50 degrees of the retina. Subjects need to fixate an �x� in the center element (not shown).

Figure 2.  Generalized multifocal electroretinogram waveform. The N1 trough and P1 peak is labeled. The amplitude and implicit time of the P1 feature of the waveform is indicated. 

Generally, prior studies have all used rigorous and complex data analyses that are not easily replicated or even readily available for use by clinicians using standard testing protocols. Studies have used complicated offline processing of the waveforms before analysis ADDIN EN.CITE  ADDIN EN.CITE.DATA  HYPERLINK \l "_ENREF_21" \o "Harrison, 2011 #1599" 21,  HYPERLINK \l "_ENREF_25" \o "Bearse, 2006 #1625" 25 (e.g. fitting templates to control data using least squares methods) as well as advanced statistical computations to identify their significant research results ADDIN EN.CITE  ADDIN EN.CITE.DATA  HYPERLINK \l "_ENREF_21" \o "Harrison, 2011 #1599" 21,  HYPERLINK \l "_ENREF_25" \o "Bearse, 2006 #1625" 25-28 (e.g. generalized estimating equations to account for correlations between intraocularly tested areas). Other studies have used specialized testing protocols to try to discern cell layer locations of the retinal processing abnormalities or understand complex temporal interactions occurring in the retina HYPERLINK \l "_ENREF_29" \o "Lung, 2012 #1577"  ADDIN EN.CITE  ADDIN EN.CITE.DATA 29-31 (e.g. retinal adaptation effects using second order kernel analysis or global flash paradigms). Indeed, continued research in the area of applying mfERGs to investigate diabetic retinopathy appear to be increasing in complexity and thus more out of reach for the clinician and perhaps harder to translate to patient management applications. 
Here we present a clinically based study examining diabetes and diabetic retinopathy using a standard clinical multifocal electroretinogram protocol with minimal data processing and straightforward statistical analysis that shows that implicit time delays, and not amplitude reductions, are indeed clinically characteristic of diabetic retinal neuropathy. 
Methods
Subjects
Forty-five subjects (27 controls/non-diabetics, 17 type 2 diabetics, 1 type 1 diabetic) participated in the study. There was no difference in the subjects� (mean � SD) ages (controls: 49.5 � 9.1 yrs., diabetics: 52.4 � 8.5 yrs., p = 0.28). All subjects were free from ocular pathologies except for diabetic retinopathy and mean ETDRS visual acuities were similar (controls: -0.04 logMAR, diabetics: 0.02 logMAR). The mean HbA1c measured at the time of testing was 5.7% for controls and 7.3% for diabetics. The mean duration of diabetes for subjects in the study was 6.9 years. Subjects had full comprehensive eye evaluations that included retinal photography and standard clinical mfERG recordings. The data collected from one random eye of each subject was analyzed (controls: 13 right eyes / 14 left eyes; diabetics: 9 right eyes / 9 left eyes). 
The nature of the study and any potential consequences of study participation were explained to the study subjects upon recruitment, and all subjects provided written informed consent before data collection. All of the procedures were in compliance with the tenets of the Declaration of Helsinki and were approved by the College�s Institutional Review Board.
Retinal photography
Color fundus photographs were obtained using a Canon CR-1 Digital Retinal Camera (Canon, Lake Success, NY). Standard 3-field photographs (45� fields each) were taken in accord with the EURODIAB study protocol.  An additional 4-fields were captured (superior nasal, superior temporal, inferior nasal, and inferior temporal) to ensure the entire mfERG stimulus array would have correlated retinal areas available for assessment. HYPERLINK \l "_ENREF_32" \o "Ng, 2008 #1402"  ADDIN EN.CITE  ADDIN EN.CITE.DATA 32 The mfERG stimulus array was superimposed onto the photos and all photos are made available for review using telemedicine protocols. HYPERLINK \l "_ENREF_33" \o "Cuadros, 2009 #1653"  ADDIN EN.CITE  ADDIN EN.CITE.DATA 33 All photographs, including controls to assess specificity of the reviewer, were graded by a single expert reviewer (MV) that had specialized training in ocular disease diagnosis and management as well as experience in retinal photography assessment. The reviewer was blind to all other subject information, including results of their ophthalmic evaluations and mfERG testing. 
Multifocal Electroretinograms: 
Standard clinical mfERGs were recorded using a widely utilized commercial stimulus-refractor unit (VERIS, version 5.24X, Electro-Diagnostic Imaging, Inc., San Mateo, CA) in accordance with ISCEV guidelines. HYPERLINK \l "_ENREF_34" \o "Hood, 2012 #1466"  ADDIN EN.CITE <EndNote><Cite><Author>Hood</Author><Year>2012</Year><RecNum>1466</RecNum><DisplayText><style face="superscript" font="Times New Roman">34</style></DisplayText><record><rec-number>1466</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">1466</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hood, D. C.</author><author>Bach, M.</author><author>Brigell, M.</author><author>Keating, D.</author><author>Kondo, M.</author><author>Lyons, J. S.</author><author>Marmor, M. F.</author><author>McCulloch, D. L.</author><author>Palmowski-Wolfe, A. M.</author></authors></contributors><auth-address>Departments of Psychology and Ophthalmology, Columbia University, New York, NY, USA. dch3@columbia.edu</auth-address><titles><title>ISCEV standard for clinical multifocal electroretinography (mfERG) (2011 edition)</title><secondary-title>Doc Ophthalmol</secondary-title><alt-title>Documenta ophthalmologica. Advances in ophthalmology</alt-title></titles><periodical><full-title>Doc Ophthalmol</full-title></periodical><pages>1-13</pages><volume>124</volume><number>1</number><edition>2011/11/01</edition><dates><year>2012</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1573-2622 (Electronic)&#xD;0012-4486 (Linking)</isbn><accession-num>22038576</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/22038576</url></related-urls></urls><electronic-resource-num>10.1007/s10633-011-9296-8</electronic-resource-num><language>eng</language></record></Cite></EndNote>34 A conventional testing protocol was used (i.e. dilated pupils, Burian-Allen bipolar corneal contact lens electrode, 103 hexagon stimulus array, CRT monitor with a frame rate of 75 Hz, high contrast alternation of stimuli � white = 200 cd/m2 and black = <2 cd/m2, 10-300 Hz band-pass filtering, amplification of 50,000 times). The mfERG results were processed with one iteration of artifact removal and spatial averaging of one-sixth an element�s neighbors using the built in commercial software. 
Data analysis
The implicit times and amplitudes of the multifocal electroretinogram were analyzed by examining the total average response of all (�whole eye�) areas (i.e. all 103 stimulus elements) examined and by examining the average response of the macula (i.e. the 7 central stimulus elements). The N1 and P1 of the responses were derived directly from within the commercial software and then visually inspected for any gross errors in identifying the peak or trough of the responses. The difference between P1 and N1 was used as the P1 amplitude. Two-tailed unpaired t-tests, assuming unequal variance, were used to detect significant (p < 0.05) retinal neural dysfunction in the diabetic subjects as compared to the control subjects.

Results
	The vast majority (83%) of diabetic subjects were free from retinopathy. The remaining eyes included in the analysis had only mild non-proliferative diabetic retinopathy, consisting of only a few microaneurysms; none of which were in the macular area as we define in this study (~4.5 deg central diameter).
The mean � SD implicit times for the �whole eye� analysis were 27.8 � 1.2 msec for controls and 29.0 � 1.1 msec for diabetics. The implicit times for the macular analysis were 28.5 � 0.98 msec for controls and 29.6 � 0.88 msec for diabetics. The amplitudes for the �whole eye� analysis were 29.1 � 5.5 nV/deg2 for controls and 28.2 � 5.1 nV/deg2 for diabetics. The mean � SD amplitudes for the macular analysis were 66.2 � 13.3 nV/deg2 for controls and 63.3 � 12.7 nV/deg2 for diabetics. 
Statistical analysis yielded significant increases in implicit time were found for subjects with diabetes in the total area examined (p = 0.002) as well as the macular area (p < 0.001) as compared to controls. No significant decreases were observed for amplitudes in the total area examined (p = 0.57) or in the macular area (p = 0.46). 

Discussion
Recent studies have identified multifocal electroretinogram abnormalities in subjects with diabetes with and without diabetic retinopathy. The majority of these studies used complex analyses or non-standard testing protocols, limiting their clinical translation. This study used standard clinical multifocal electroretinogram testing and analysis using standard commercial software to examine a group of diabetic subjects with minimal to no diabetic retinopathy. Significant (generalized and macular) retinal neural dysfunction was observed. The P1 implicit time was found to be delayed in subjects with diabetes, but not the N1-P1 amplitude � in agreement with previous studies that used more complex analyses. HYPERLINK \l "_ENREF_25" \o "Bearse, 2006 #1625"  ADDIN EN.CITE <EndNote><Cite><Author>Bearse</Author><Year>2006</Year><RecNum>1625</RecNum><DisplayText><style face="superscript" font="Times New Roman">25</style></DisplayText><record><rec-number>1625</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">1625</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bearse, M. A., Jr.</author><author>Adams, A. J.</author><author>Han, Y.</author><author>Schneck, M. E.</author><author>Ng, J.</author><author>Bronson-Castain, K.</author><author>Barez, S.</author></authors></contributors><auth-address>School of Optometry and Vision Science Program, University of California, Berkeley, Berkeley, CA 94720-2020, USA.</auth-address><titles><title>A multifocal electroretinogram model predicting the development of diabetic retinopathy</title><secondary-title>Prog Retin Eye Res</secondary-title><alt-title>Progress in retinal and eye research</alt-title></titles><periodical><full-title>Prog Retin Eye Res</full-title></periodical><alt-periodical><full-title>Progress in Retinal and Eye Research</full-title><abbr-1>Prog Retin Eye Res</abbr-1></alt-periodical><pages>425-48</pages><volume>25</volume><number>5</number><edition>2006/09/05</edition><keywords><keyword>Diabetic Retinopathy/*diagnosis/physiopathology</keyword><keyword>Electroretinography/methods</keyword><keyword>Humans</keyword><keyword>Prognosis</keyword><keyword>Retina/*physiopathology</keyword></keywords><dates><year>2006</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>1350-9462 (Print)&#xD;1350-9462 (Linking)</isbn><accession-num>16949855</accession-num><work-type>Research Support, N.I.H., Extramural&#xD;Review</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/16949855</url></related-urls></urls><custom2>2773701</custom2><electronic-resource-num>10.1016/j.preteyeres.2006.07.001</electronic-resource-num><language>eng</language></record></Cite></EndNote>25 
A recent study by Tyrberg et al. HYPERLINK \l "_ENREF_35" \o "Tyrberg, 2011 #1595"  ADDIN EN.CITE  ADDIN EN.CITE.DATA 35 using somewhat similar analyses to this study is in agreement with our findings, though the exact method of derivation of N1 and P1 are not explicitly described in the study. There are several noticeable differences between this study and Tyrberg et al.�s study. Our study participants also had minimal to no diabetic retinopathy, but on average had a much longer duration of diabetes, higher HbA1c levels, and a substantially younger average age. The mean amplitudes for both the whole eye analysis and the macular analysis were higher in this study as compared to Tyrberg et al.�s. This is likely attributed to differences in the mean age of the subjects between the two studies. The data in this study is also more balanced with regard to gender and eye (right or left) compared with Tyrberg et al�s. Thus, this present study complements the previous findings. Additionally, both studies provide raw amplitudes and implicit times that can be used as reference normative data for other clinicians; as opposed to Z-scores that other authors have used. HYPERLINK \l "_ENREF_36" \o "Bearse, 2004 #111"  ADDIN EN.CITE  ADDIN EN.CITE.DATA 36-38
Standard clinical electrodiagnostic testing can reveal widespread or macular retinal neural dysfunction among patients with diabetes. Greater retinal dysfunction as detected using the mfERG represents retinal neuropathy as a result of diabetes and this dysfunction can exist prior to clinically visible vascular complications. This aspect of clinical testing could be important given that patients with diabetes can presumably be in different stages of retinal neuropathy while maintaining the same clinical stage (e.g. no clinically visible retinopathy or minimal/mild non-proliferative diabetic retinopathy). Patients with more severe retinal neuropathy may have additional subjective complaints and difficulties that may explain, or correlate with, otherwise unexplainable deficits that may be discovered by psychophysical testing (e.g. glare recovery, contrast sensitivity, dark adaptation). Thus, the findings presented in this study should encourage clinicians to consider evaluating this aspect of diabetic retinal neuropathy.  

Acknowledgements
The authors thank Dr. William Ridder III, Rachelle Lin, and Brian Shih for assistance with data collection and analysis.














 ADDIN EN.REFLIST 1.	Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004;27:1047-53.
2.	Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract 2011;94:311-21.
3.	National diabetes fact sheet: national estimates and general information on diabetes and prediabetes in the United States, 2011. In: Prevention CfDCa, editor. Atlanta, GA: U.S. Department of Health and Human Services; 2011.
4.	Brinchmann-Hansen O, Dahl-Jorgensen K, Hanssen KF, Sandvik L. Macular recovery time, diabetic retinopathy, and clinical variables after 7 years of improved glycemic control. Acta Ophthalmol (Copenh) 1992;70:235-42.
5.	Frost-Larsen K. Macular recovery recorded by nyctometry in insulin-dependent diabetes mellitus. Acta Ophthalmol Suppl 1991:1-39.
6.	Yamazaki H, Adachi-Usami E, Chiba J. Contrast thresholds of diabetic patients determined by VECP and psychophysical measurements. Acta Ophthalmol (Copenh) 1982;60:386-92.
7.	Greenstein V, Sarter B, Hood D, Noble K, Carr R. Hue discrimination and S cone pathway sensitivity in early diabetic retinopathy. Invest Ophthalmol Vis Sci 1990;31:1008-14.
8.	Greenstein VC, Shapiro A, Zaidi Q, Hood DC. Psychophysical evidence for post-receptoral sensitivity loss in diabetics. Invest Ophthalmol Vis Sci 1992;33:2781-90.
9.	Greenstein VC, Thomas SR, Blaustein H, Koenig K, Carr RE. Effects of early diabetic retinopathy on rod system sensitivity. Optom Vis Sci 1993;70:18-23.
10.	Greite JH ZH, Adamczyk R. Visual field in diabetic retinopathy. Documenta Ophthalmol Proc Series 1980;26.
11.	Adams AJ, Bearse MA, Jr. Retinal neuropathy precedes vasculopathy in diabetes: a function-based opportunity for early treatment intervention? Clin Exp Optom 2012;95:256-65.
12.	Kempen JH. The Prevalence of Diabetic Retinopathy Among Adults in the United States. Archives of Ophthalmology 2003;122:552-63.
13.	Fong DS, Aiello L, Gardner TW, King GL, Blankenship G, Cavallerano JD, Ferris FL, 3rd, Klein R. Diabetic retinopathy. Diabetes Care 2003;26:226-9.
14.	Mohamed Q, Gillies MC, Wong TY. Management of diabetic retinopathy: a systematic review. Jama 2007;298:902-16.
15.	Tonello M, Costa RA, Almeida FP, Barbosa JC, Scott IU, Jorge R. Panretinal photocoagulation versus PRP plus intravitreal bevacizumab for high-risk proliferative diabetic retinopathy (IBeHi study). Acta Ophthalmol 2008;86:385-9.
16.	Parikh SSM, H. H.; Desai, B.I. Advances in development of bevacizumab, a humanized antiangiogenic therapeutic monoclonal antibody targeting VEGF in 
cancer cells. Int J Pharm Biomed Sci 2012;3:155-63.
17.	Bressler NM, Beck RW, Ferris FL, 3rd. Panretinal photocoagulation for proliferative diabetic retinopathy. N Engl J Med 2011;365:1520-6.
18.	Krepler K, Wagner J, Sacu S, Wedrich A. The effect of intravitreal triamcinolone on diabetic macular oedema. Graefes Arch Clin Exp Ophthalmol 2005;243:478-81.
19.	Mitchell P, Annemans L, Gallagher M, Hasan R, Thomas S, Gairy K, Knudsen M, Onwordi H. Cost-effectiveness of ranibizumab in treatment of diabetic macular oedema (DME) causing visual impairment: evidence from the RESTORE trial. Br J Ophthalmol 2012;96:688-93.
20.	Kono T, Shiga S, Takesue Y, Sakamoto T. Long-term results of pars plana vitrectomy combined with filtering surgery for neovascular glaucoma. Ophthalmic Surg Lasers Imaging 2005;36:211-6.
21.	Harrison WW, Bearse MA, Jr., Schneck ME, Wolff BE, Jewell NP, Barez S, Mick AB, Dolan BJ, Adams AJ. Prediction, by retinal location, of the onset of diabetic edema in patients with nonproliferative diabetic retinopathy. Invest Ophthalmol Vis Sci 2011;52:6825-31.
22.	Kondo M, Miyake Y, Horiguchi M, Suzuki S, Tanikawa A. Clinical evaluation of multifocal electroretinogram. Invest Ophthalmol Vis Sci 1995;36:2146-50.
23.	Hood DC, Frishman LJ, Saszik S, Viswanathan S. Retinal origins of the primate multifocal ERG: implications for the human response. Invest Ophthalmol Vis Sci 2002;43:1673-85.
24.	Fortune B, Schneck ME, Adams AJ. Multifocal electroretinogram delays reveal local retinal dysfunction in early diabetic retinopathy. Invest Ophthalmol Vis Sci 1999;40:2638-51.
25.	Bearse MA, Jr., Adams AJ, Han Y, Schneck ME, Ng J, Bronson-Castain K, Barez S. A multifocal electroretinogram model predicting the development of diabetic retinopathy. Prog Retin Eye Res 2006;25:425-48.
26.	Harrison WW, Bearse MA, Jr., Ng JS, Jewell NP, Barez S, Burger D, Schneck ME, Adams AJ. Multifocal electroretinograms predict onset of diabetic retinopathy in adult patients with diabetes. Invest Ophthalmol Vis Sci 2011;52:772-7.
27.	Wright T, Cortese F, Nilsson J, Westall C. Analysis of multifocal electroretinograms from a population with type 1 diabetes using partial least squares reveals spatial and temporal distribution of changes to retinal function. Doc Ophthalmol 2012;125:31-42.
28.	Xu J, Hu G, Huang T, Huang H, Chen B. Using multifocal ERG responses to discriminate diabetic retinopathy. Doc Ophthalmol 2006;112:201-7.
29.	Lung JC, Swann PG, Wong DS, Chan HH. Global flash multifocal electroretinogram: early detection of local functional changes and its correlations with optical coherence tomography and visual field tests in diabetic eyes. Doc Ophthalmol 2012;125:123-35.
30.	Chan HH, Chu PH, Lung JC, Ho WC, Ting PW, Sum RW, Ng YF. Detection of early functional changes in diabetic retina using slow double-stimulation mfERG paradigm. Br J Ophthalmol 2011;95:1560-3.
31.	Bronson-Castain KW, Bearse MA, Jr., Han Y, Schneck ME, Barez S, Adams AJ. Association between multifocal ERG implicit time delays and adaptation in patients with diabetes. Invest Ophthalmol Vis Sci 2007;48:5250-6.
32.	Ng JS, Bearse MA, Jr., Schneck ME, Barez S, Adams AJ. Local diabetic retinopathy prediction by multifocal ERG delays over 3 years. Invest Ophthalmol Vis Sci 2008;49:1622-8.
33.	Cuadros J, Bresnick G. EyePACS: an adaptable telemedicine system for diabetic retinopathy screening. J Diabetes Sci Technol 2009;3:509-16.
34.	Hood DC, Bach M, Brigell M, Keating D, Kondo M, Lyons JS, Marmor MF, McCulloch DL, Palmowski-Wolfe AM. ISCEV standard for clinical multifocal electroretinography (mfERG) (2011 edition). Doc Ophthalmol 2012;124:1-13.
35.	Tyrberg M, Lindblad U, Melander A, Lovestam-Adrian M, Ponjavic V, Andreasson S. Electrophysiological studies in newly onset type 2 diabetes without visible vascular retinopathy. Doc Ophthalmol 2011;123:193-8.
36.	Bearse MA, Jr., Han Y, Schneck ME, Adams AJ. Retinal function in normal and diabetic eyes mapped with the slow flash multifocal electroretinogram. Invest Ophthalmol Vis Sci 2004;45:296-304.
37.	Dhamdhere KP, Bearse MA, Jr., Harrison W, Barez S, Schneck ME, Adams AJ. Associations between local retinal thickness and function in early diabetes. Invest Ophthalmol Vis Sci 2012;53:6122-8.
38.	Lung JC, Swann PG, Chan HH. Early local functional changes in the human diabetic retina: a global flash multifocal electroretinogram study. Graefes Arch Clin Exp Ophthalmol 2012;250:1745-54.










 PAGE   \* MERGEFORMAT 16




13Z�*
+
,
L
M
_
a
i
�
 423?@_iwx������������

#
(
)
E
P
|
�
�
�
�
c�������������������ɿ޻�޻����⛣ޗޓޏ�ޗޏޏޓޏ�h��hwh�h{@�h�;5�h{@�h_f�5�	h�;5�h�U�h_f�h�rh04jh_f�0JUh�+h_f�0Jjh_f�Uh�;h_f�	h_f�5�	h��5�	h:	�5�h:	�h��h:	�h:	�834=	>	+
,
8
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
[
\
]
^
_
`
a
����������������������������$a$gd_f�a
b
c
d
e
f
g
h
i
�
�
U~����AB^_x����������������������������$a$gd_f�������������������������c��������������������������
$d�a$gd_f�$a$gd_f�$
�a$gd_f�ckv���������138Qhm����	��������
-1=V`����78GH\]^_`���������������������������������������������j�h7<�h_f�U�jh_f�Ujh_f�Ujh7<�h_f�Uh7<�h_f�	h_f�5�h��h_f�5�h{M8hu]h90�h�uNhV^�hwh��h_f�hV^�h{@�h_f�5�6�1V��`�/�<�IYY�Y�Y�Z�Zf`���������������$��d�1$`��a$gd#F�$d�1$a$gd��$��d�1$`��a$gd��$d�1$a$gd�R�$��d�1$`��a$gd�R�$��d�1$`��a$gd_f�d�gd_f�
$d�a$gd_f�`a�������������cm�������������������������𚓏�������s���a�S�h7<�h��H*mHnHu#�jF;h��H*UmHnHu�j�,h7<�h_f�U�jh7<�h_f�Uh_f�h7<�h_f�jh7<�h_f�U#�j�h��H*UmHnHuh�h_f�H*mHnHuh�h��H*mHnHu#�j,h��H*UmHnHuh��H*mHnHujh��H*UmHnHu���#$%&'(5T������YZ[\]_`���VW����"�"�"�"�"�"�����㭦�������y������������n���`���h�X>h��H*mHnHu�j�<h��Uh7<�h��jh7<�h��U�j,<h��Uh��jh��Uh_f�h7<�h_f�jh7<�h_f�Uh7<�h��H*mHnHu#�j�;h��H*UmHnHuh��H*mHnHujh��H*UmHnHuh7<�h_f�H*mHnHu%�"�"�"�"W#X#�#�#�#�#�#�#�#�#�#�#�#�#�#$3$4$7$k$l$n$o$�$�$�$�$�$�$�$�$�$�$�$ %!%R%S%U%�(������������鹵����������}��y�y�y�y���n���j�uh��Uh_f��jXuh�sUh�sjh�sU�j�th#U�jrth#U�j�sh#Uh#jh#Uh�r^h��H*mHnHu�j�=h��U�j=h��Uh��jh��Uh90�h7<�h_f�h�?F+�(�(�(�(�(�(�(�(")5)6)e)f)h)�/�/�/�/�/000000!0,0�0�0�0�0�0�0�0�7�7�7�78L8i8j8k8�8�8�8�8�8�8�8�8�8�8�8@9D9�9�9�9�9�9������������������������ּ�������ֱ��֦�����垚h�;hJ#�h90��j�wh��U�j*wh��U�j�vh��Uh�}��j@vh��Uh��h��h7<�h_f�h_f�h�r^h��H*mHnHujh��U<�9:
:::1:2:4:5:i:j:k:m:n:p:q:�:�:�:�:�:�:�:;;D;E;G;V;W;k;l;n;p;r;�;�;�<������Ͻگڡ�Ϗگ��{p{{e��a�h�;�j؞h��U�jc�h��Uh��jh��Uh_f�h90�#�j�h��H*UmHnHuhJ#�hJ#�H*mHnHuhJ#�h��H*mHnHu#�jy�h��H*UmHnHuh��H*mHnHujh��H*UmHnHu�j�hJ#�UjhJ#�UhJ#�%�<>>F>G>I>X>Y>m>n>p>r>t>�>�>??7?8?:?�F�F�F�F�F�GH%H7H�I�I�I$J8JAJBJQJRJfJgJhJiJjJ����������������������������������rjh��H*UmHnHu�j޲hJ#�UjhJ#�UhJ#�jh_f�Uh��h�}�h_f�hJ#�h��H*mHnHu�ji�h��Uh90�h�r^h��H*mHnHu�jI�h��U�jԨh��Uh��jh��Uh7<�h_f�*jJ�J�J�J�J�J�J�J�J�J�J�J�J�JK
KAKbKqK�K�K�K�K�K�K�R�R�R�R�RmS�S�S�S�S�S�STMT\T����Ը����Ԟ���������u���Ƅ�qmimeieimih�jh�r�h�*�h�}��j��h��Uh��jh��Uh#F�h7<�h�h7<�h_f�jh_f�U#�j9�h��H*UmHnHuhJ#�hJ#�H*mHnHuhJ#�h��H*mHnHujh��H*UmHnHu#�j��h��H*UmHnHuh��H*mHnHu'\T�T�T�T�TUU!U#U�U�U�U�U�UVVVVVVVV`VdV~V�V�V�V�V�VW(W9W:W;WJWKW_W`WaWbWcW�W����������������������������������{h��H*mHnHujh��H*UmHnHu�j��hJ#�UjhJ#�UhJ#�jh�9_Uh90�h#F�hJ#�h��H*mHnHu�j��h��U�j#�h��Uh��jh��Uh�#�h�r�h�*�h�*�H*h�*�*�W�W�W�W�W�W�W�W�W�W�W�W�W�W�WX%XmXnX}X~X�X�X�X�X�X�X�X�X�X�X�X�XY�����޷���ޝ���������z��޷h����޷#�j4�h��H*UmHnHu�j�hJ#�UjhJ#�UhJ#�h#F�h�h�*�jh�9_U#�j��h��H*UmHnHuh��H*mHnHuhJ#�hJ#�H*mHnHuhJ#�h��H*mHnHujh��H*UmHnHu#�j2�h��H*UmHnHu!YYYY	Y
YY
YYY�Y�Y�Y�Y�Y�Y�Z�Z�Z�Z�Z�Z�Z�Z�Z[L[j[�[�[�[�[�[�[�[�[�[�����ļ����������Č�Ĉ��Ĉ���|t|it���jhJ#�UjhJ#�UhJ#�h�;h]A%h�*�h7<�h_f�h�i(h��h�R�h��5�	h��5�j`�h��Uh�R�h�R�5�h�R�j�h��Uh#F�jh�9_UhJ#�h��H*mHnHujh��H*UmHnHu#�j��h��H*UmHnHu$�[�[�[�[�[\\\5\6\7\9\:\;\�\�\�\�\]]]]]9]:];]=]>]@]A]s]t]u]z]{]|]�]����Ը����Ԟ���������q��Ը�_��Ԟ�#�j�Ph��H*UmHnHu#�jcPh��H*UmHnHu�j�%hJ#�UjhJ#�UhJ#�h#F�jh�9_U#�jL%h��H*UmHnHuhJ#�hJ#�H*mHnHuhJ#�h��H*mHnHujh��H*UmHnHu#�j�$h��H*UmHnHuh��H*mHnHu$�]�]�]^-^8^U^w^�^�^�^�^�^�^�^�^�^�^�^___
__�_�_"`7`d`e`f`(aKa�a�a�a�a�a�a
bbbbb2bxb~bb�b�b�b���������������������������������������������h�uNh�h�h!y�h	�h{M8h{@�h	�6�	h	�5�h{@�h	�5�h7<�h]A%h90�h_f�h�Zh�hJ#�h��H*mHnHu�j�Qh��U�jMQh��Uh��jh��Uh#F�h]A%h�;2f`�a�a�a-e�f�fk0kTtbt8w9wAw������������w
$d�a$gd_f�$��d�`��a$gd�;$��d�1$`��a$gd	�$d�1$a$gd_f�
��d�1$`��gd�S$d�1$a$gd�S$��d�`��a$gd�H$��d�`��a$gd	�
$d�a$gd	�$��d�1$`��a$gd�;
�b�b�b�b�b�b�b�b�bc*c9cwcyc}c�c�c�c�c�c�c�c�cd�d�d�d�d�dee+e-e�e�e�e�ef/f=fYf^fufwf�f�f�f�f�f�fgggRhSh�h�h�h�h�h�h���������������������������������������ſſſ��������j�gh��UaJ
h��aJjh��UaJ
h�SaJh7<�h�SaJ
h
�aJ	h�S6�h{M8h�EZh�;h-)Ph�Hh90�h	�h�h�uNh	�<�h�h�h�h�h*i3i4i5ihiiikizi{i�i�i�i�i�i�j�j�j�j�jkkkk-k0kDk\k_kok�k�k�k��������ƹ���Ƭ��ҖҖҖҍ��xtmieieih]A%h_f�h7<�h_f�h�;h]A%h_f�6�	h�;6�h]A%h]A%6�h7<�h�SaJ
h�;aJh�G"h��H*aJmHnHu�j<qh��UaJ�j�ph��UaJ
h��aJ
h�aJ
h�SaJhJ#�h��H*aJmHnHujh��UaJ�jkhh��UaJ$�k�k/l0l2l]r^r`rbrcrRsSsgshsts}s�s�s�stStTtatbtsttt�t�t�t�t�tu7u{v8w9w@wAwTwWwZw�w�w�w�wxxxx#x$x(xtxux�x�����������������ֽ�ŴŴŰŬŬ����������ғ�ҏҏ����h�;h�z�h{M8	h_f�5�h{@�h_f�5�h�i(h�EZh
�h�Hh�?�	h	�6�h{@�h	�6�h	�h-)P	h�H*h�h_f�h�G"h��H*mHnHu�j�yh��Uh��jh��U6Awux^z�{�{�{���������������� �!�������������������
$d�a$gd�$��d�`��a$gd04$��d�`��a$gd	�
$d�a$gd_f�$��d�`��a$gd{M8$��d�`��a$gd�EZ
$d�a$gd	��x�x�x�x�x*y,y1y=yNyRy�y�y�y�y�y�y�y�y�y�y z'z(z3zAzEzLzMz|zj{�{�{�{�{�{�{}=}C}D}P}g}n}r}t}u}�}�}�}�}c~�~�~�~�~�~y�z�|�~�����������������������������������������������������ԟh�ZhJ#�h��H*mHnHu�j%zh��Uh��jh��UhRRh�`�h�?�h!y�h{@�h_f�5�h{@�h	�5�h	�h�Hh�HH*h{M8h-)Ph�H>����������ԆՆ׆������������*�+�0�1�E�R���������ćχ��!�*�1�2�7�8�A�R�]�a�c�o�����������È*�L���ĉƉ��%�:�K�O�P�X�c�q�}������������������������������������������������������������������h�	�h�z�h{Lh�?�h�h!y�h�;hRRh�Zh�G"h��H*mHnHu�j{h��U�j�zh��Uh��jh��Uh�h�s@���������� �Q�R�T�c�d�x�y�{������_�j�v���ʌZ�a�l���ύ�����(�A�M�N�^�r������������������ɏ؏��������������������������������������������������hV^�h�{�h{@�h�5�	h�5�h04h�h��h��h�z�hJ#�hRRh�G"h��H*mHnHu�jʃh��U�jU�h��Uh��jh��Uh�;h�Zh��h{Lh�?�5��&�(�)�;�<�������������������������� ���������������������jh_f�UmHnHuh�)mHnHuhfH�jhfH�Uh��mHnHujh_f�Uh�;h��h_f�!�"�#�$�%�&�'�(����n�H�̓z�*�ϕj�ؖ��
��������̚X�����������������������������d�gd��	d���gd��
$d�a$gd_f������̞f��̠��������ܥ��g���Ҩ��i�-�����������������������������������d�gd_f�gd_f�d�gd��	d���gd������������������ �����������gd_f�$a$d�gd_f�
90P1�h:p����/ ��=!��"��#��$��%��������D<EndNote><Cite><Author>Wild</Author><Year>2004</Year><RecNum>682</RecNum><DisplayText><style face="superscript" font="Times New Roman">1, 2</style></DisplayText><record><rec-number>682</rec-number><foreign-keys><key app="EN" db-id="e5tfs5v2rp5r0ge9sscvwr0msavadprtrf2t">682</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wild, S.</author><author>Roglic, G.</author><author>Green, A.</author><author>Sicree, R.</author><author>King, H.</author></authors></contributors><auth-address>Public Health Sciences, University of Edinburgh, Edinburgh, Scotland. sarah.wild@ed.ac.uk</auth-address><titles><title>Global prevalence of diabetes: estimates for the year 2000 and projections for 2030</title><secondary-title>Diabetes Care</secondary-title><alt-title>Diabetes care</alt-title></titles><periodical><full-title>Diabetes Care</full-title><abbr-1>Diabetes care</abbr-1></periodical><alt-periodical><full-title>Diabetes Care</full-title><abbr-1>Diabetes care</abbr-1></alt-periodical><pages>1047-53</pages><volume>27</volume><number>5</number><edition>2004/04/28</edition><keywords><keyword>Adult</keyword><keyword>Age Distribution</keyword><keyword>Diabetes Mellitus/*epidemiology</keyword><keyword>Diabetes Mellitus, Type 1/epidemiology</keyword><keyword>Diabetes Mellitus, Type 2/epidemiology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Prevalence</keyword><keyword>World Health</keyword><keyword>World Health Organization</keyword></keywords><dates><year>2004</year><pub-dates><date>May</date></pub-dates></dates><isbn>0149-5992 (Print)&#xD;0149-5992 (Linking)</isbn><accession-num>15111519</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/15111519</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Whiting</Author><Year>2011</Year><RecNum>681</RecNum><record><rec-number>681</rec-number><foreign-keys><key app="EN" db-id="e5tfs5v2rp5r0ge9sscvwr0msavadprtrf2t">681</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Whiting, D. R.</author><author>Guariguata, L.</author><author>Weil, C.</author><author>Shaw, J.</author></authors></contributors><auth-address>International Diabetes Federation, Brussels, Belgium. david@davidwhiting.me.uk</auth-address><titles><title>IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030</title><secondary-title>Diabetes Res Clin Pract</secondary-title><alt-title>Diabetes research and clinical practice</alt-title></titles><periodical><full-title>Diabetes Res Clin Pract</full-title><abbr-1>Diabetes research and clinical practice</abbr-1></periodical><alt-periodical><full-title>Diabetes Res Clin Pract</full-title><abbr-1>Diabetes research and clinical practice</abbr-1></alt-periodical><pages>311-21</pages><volume>94</volume><number>3</number><edition>2011/11/15</edition><keywords><keyword>Diabetes Mellitus/*epidemiology</keyword><keyword>Humans</keyword><keyword>Models, Statistical</keyword><keyword>Prevalence</keyword><keyword>Time Factors</keyword><keyword>*World Health</keyword><keyword>World Health Organization</keyword></keywords><dates><year>2011</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>1872-8227 (Electronic)&#xD;0168-8227 (Linking)</isbn><accession-num>22079683</accession-num><work-type>Research Support, Non-U.S. Gov&apos;t</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/22079683</url></related-urls></urls><electronic-resource-num>10.1016/j.diabres.2011.10.029</electronic-resource-num><language>eng</language></record></Cite></EndNote>�D<EndNote><Cite><Author>Wild</Author><Year>2004</Year><RecNum>682</RecNum><DisplayText><style face="superscript" font="Times New Roman">1, 2</style></DisplayText><record><rec-number>682</rec-number><foreign-keys><key app="EN" db-id="e5tfs5v2rp5r0ge9sscvwr0msavadprtrf2t">682</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wild, S.</author><author>Roglic, G.</author><author>Green, A.</author><author>Sicree, R.</author><author>King, H.</author></authors></contributors><auth-address>Public Health Sciences, University of Edinburgh, Edinburgh, Scotland. sarah.wild@ed.ac.uk</auth-address><titles><title>Global prevalence of diabetes: estimates for the year 2000 and projections for 2030</title><secondary-title>Diabetes Care</secondary-title><alt-title>Diabetes care</alt-title></titles><periodical><full-title>Diabetes Care</full-title><abbr-1>Diabetes care</abbr-1></periodical><alt-periodical><full-title>Diabetes Care</full-title><abbr-1>Diabetes care</abbr-1></alt-periodical><pages>1047-53</pages><volume>27</volume><number>5</number><edition>2004/04/28</edition><keywords><keyword>Adult</keyword><keyword>Age Distribution</keyword><keyword>Diabetes Mellitus/*epidemiology</keyword><keyword>Diabetes Mellitus, Type 1/epidemiology</keyword><keyword>Diabetes Mellitus, Type 2/epidemiology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Prevalence</keyword><keyword>World Health</keyword><keyword>World Health Organization</keyword></keywords><dates><year>2004</year><pub-dates><date>May</date></pub-dates></dates><isbn>0149-5992 (Print)&#xD;0149-5992 (Linking)</isbn><accession-num>15111519</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/15111519</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Whiting</Author><Year>2011</Year><RecNum>681</RecNum><record><rec-number>681</rec-number><foreign-keys><key app="EN" db-id="e5tfs5v2rp5r0ge9sscvwr0msavadprtrf2t">681</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Whiting, D. R.</author><author>Guariguata, L.</author><author>Weil, C.</author><author>Shaw, J.</author></authors></contributors><auth-address>International Diabetes Federation, Brussels, Belgium. david@davidwhiting.me.uk</auth-address><titles><title>IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030</title><secondary-title>Diabetes Res Clin Pract</secondary-title><alt-title>Diabetes research and clinical practice</alt-title></titles><periodical><full-title>Diabetes Res Clin Pract</full-title><abbr-1>Diabetes research and clinical practice</abbr-1></periodical><alt-periodical><full-title>Diabetes Res Clin Pract</full-title><abbr-1>Diabetes research and clinical practice</abbr-1></alt-periodical><pages>311-21</pages><volume>94</volume><number>3</number><edition>2011/11/15</edition><keywords><keyword>Diabetes Mellitus/*epidemiology</keyword><keyword>Humans</keyword><keyword>Models, Statistical</keyword><keyword>Prevalence</keyword><keyword>Time Factors</keyword><keyword>*World Health</keyword><keyword>World Health Organization</keyword></keywords><dates><year>2011</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>1872-8227 (Electronic)&#xD;0168-8227 (Linking)</isbn><accession-num>22079683</accession-num><work-type>Research Support, Non-U.S. Gov&apos;t</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/22079683</url></related-urls></urls><electronic-resource-num>10.1016/j.diabres.2011.10.029</electronic-resource-num><language>eng</language></record></Cite></EndNote>sD���y������K�	_ENREF_1sD���y������K�	_ENREF_2�D<EndNote><Cite><Author>Whiting</Author><Year>2011</Year><RecNum>681</RecNum><DisplayText><style face="superscript" font="Times New Roman">1, 2</style></DisplayText><record><rec-number>681</rec-number><foreign-keys><key app="EN" db-id="e5tfs5v2rp5r0ge9sscvwr0msavadprtrf2t">681</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Whiting, D. R.</author><author>Guariguata, L.</author><author>Weil, C.</author><author>Shaw, J.</author></authors></contributors><auth-address>International Diabetes Federation, Brussels, Belgium. david@davidwhiting.me.uk</auth-address><titles><title>IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030</title><secondary-title>Diabetes Res Clin Pract</secondary-title><alt-title>Diabetes research and clinical practice</alt-title></titles><periodical><full-title>Diabetes Res Clin Pract</full-title><abbr-1>Diabetes research and clinical practice</abbr-1></periodical><alt-periodical><full-title>Diabetes Res Clin Pract</full-title><abbr-1>Diabetes research and clinical practice</abbr-1></alt-periodical><pages>311-21</pages><volume>94</volume><number>3</number><edition>2011/11/15</edition><keywords><keyword>Diabetes Mellitus/*epidemiology</keyword><keyword>Humans</keyword><keyword>Models, Statistical</keyword><keyword>Prevalence</keyword><keyword>Time Factors</keyword><keyword>*World Health</keyword><keyword>World Health Organization</keyword></keywords><dates><year>2011</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>1872-8227 (Electronic)&#xD;0168-8227 (Linking)</isbn><accession-num>22079683</accession-num><work-type>Research Support, Non-U.S. Gov&apos;t</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/22079683</url></related-urls></urls><electronic-resource-num>10.1016/j.diabres.2011.10.029</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Wild</Author><Year>2004</Year><RecNum>682</RecNum><record><rec-number>682</rec-number><foreign-keys><key app="EN" db-id="e5tfs5v2rp5r0ge9sscvwr0msavadprtrf2t">682</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wild, S.</author><author>Roglic, G.</author><author>Green, A.</author><author>Sicree, R.</author><author>King, H.</author></authors></contributors><auth-address>Public Health Sciences, University of Edinburgh, Edinburgh, Scotland. sarah.wild@ed.ac.uk</auth-address><titles><title>Global prevalence of diabetes: estimates for the year 2000 and projections for 2030</title><secondary-title>Diabetes Care</secondary-title><alt-title>Diabetes care</alt-title></titles><periodical><full-title>Diabetes Care</full-title><abbr-1>Diabetes care</abbr-1></periodical><alt-periodical><full-title>Diabetes Care</full-title><abbr-1>Diabetes care</abbr-1></alt-periodical><pages>1047-53</pages><volume>27</volume><number>5</number><edition>2004/04/28</edition><keywords><keyword>Adult</keyword><keyword>Age Distribution</keyword><keyword>Diabetes Mellitus/*epidemiology</keyword><keyword>Diabetes Mellitus, Type 1/epidemiology</keyword><keyword>Diabetes Mellitus, Type 2/epidemiology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Prevalence</keyword><keyword>World Health</keyword><keyword>World Health Organization</keyword></keywords><dates><year>2004</year><pub-dates><date>May</date></pub-dates></dates><isbn>0149-5992 (Print)&#xD;0149-5992 (Linking)</isbn><accession-num>15111519</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/15111519</url></related-urls></urls><language>eng</language></record></Cite></EndNote>�D<EndNote><Cite><Author>Whiting</Author><Year>2011</Year><RecNum>681</RecNum><DisplayText><style face="superscript" font="Times New Roman">1, 2</style></DisplayText><record><rec-number>681</rec-number><foreign-keys><key app="EN" db-id="e5tfs5v2rp5r0ge9sscvwr0msavadprtrf2t">681</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Whiting, D. R.</author><author>Guariguata, L.</author><author>Weil, C.</author><author>Shaw, J.</author></authors></contributors><auth-address>International Diabetes Federation, Brussels, Belgium. david@davidwhiting.me.uk</auth-address><titles><title>IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030</title><secondary-title>Diabetes Res Clin Pract</secondary-title><alt-title>Diabetes research and clinical practice</alt-title></titles><periodical><full-title>Diabetes Res Clin Pract</full-title><abbr-1>Diabetes research and clinical practice</abbr-1></periodical><alt-periodical><full-title>Diabetes Res Clin Pract</full-title><abbr-1>Diabetes research and clinical practice</abbr-1></alt-periodical><pages>311-21</pages><volume>94</volume><number>3</number><edition>2011/11/15</edition><keywords><keyword>Diabetes Mellitus/*epidemiology</keyword><keyword>Humans</keyword><keyword>Models, Statistical</keyword><keyword>Prevalence</keyword><keyword>Time Factors</keyword><keyword>*World Health</keyword><keyword>World Health Organization</keyword></keywords><dates><year>2011</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>1872-8227 (Electronic)&#xD;0168-8227 (Linking)</isbn><accession-num>22079683</accession-num><work-type>Research Support, Non-U.S. Gov&apos;t</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/22079683</url></related-urls></urls><electronic-resource-num>10.1016/j.diabres.2011.10.029</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Wild</Author><Year>2004</Year><RecNum>682</RecNum><record><rec-number>682</rec-number><foreign-keys><key app="EN" db-id="e5tfs5v2rp5r0ge9sscvwr0msavadprtrf2t">682</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wild, S.</author><author>Roglic, G.</author><author>Green, A.</author><author>Sicree, R.</author><author>King, H.</author></authors></contributors><auth-address>Public Health Sciences, University of Edinburgh, Edinburgh, Scotland. sarah.wild@ed.ac.uk</auth-address><titles><title>Global prevalence of diabetes: estimates for the year 2000 and projections for 2030</title><secondary-title>Diabetes Care</secondary-title><alt-title>Diabetes care</alt-title></titles><periodical><full-title>Diabetes Care</full-title><abbr-1>Diabetes care</abbr-1></periodical><alt-periodical><full-title>Diabetes Care</full-title><abbr-1>Diabetes care</abbr-1></alt-periodical><pages>1047-53</pages><volume>27</volume><number>5</number><edition>2004/04/28</edition><keywords><keyword>Adult</keyword><keyword>Age Distribution</keyword><keyword>Diabetes Mellitus/*epidemiology</keyword><keyword>Diabetes Mellitus, Type 1/epidemiology</keyword><keyword>Diabetes Mellitus, Type 2/epidemiology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Prevalence</keyword><keyword>World Health</keyword><keyword>World Health Organization</keyword></keywords><dates><year>2004</year><pub-dates><date>May</date></pub-dates></dates><isbn>0149-5992 (Print)&#xD;0149-5992 (Linking)</isbn><accession-num>15111519</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/15111519</url></related-urls></urls><language>eng</language></record></Cite></EndNote>sD���y������K�	_ENREF_1sD���y������K�	_ENREF_2sD���y������K�	_ENREF_2sD���y������K�	_ENREF_3sD���y������K�	_ENREF_4z6D<EndNote><Cite><Author>Brinchmann-Hansen</Author><Year>1992</Year><RecNum>1648</RecNum><DisplayText><style face="superscript" font="Times New Roman">4-11</style></DisplayText><record><rec-number>1648</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">1648</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Brinchmann-Hansen, O.</author><author>Dahl-Jorgensen, K.</author><author>Hanssen, K. F.</author><author>Sandvik, L.</author></authors></contributors><auth-address>Department of Ophthalmology, Trondheim University Hospital, Norway.</auth-address><titles><title>Macular recovery time, diabetic retinopathy, and clinical variables after 7 years of improved glycemic control</title><secondary-title>Acta Ophthalmol (Copenh)</secondary-title><alt-title>Acta ophthalmologica</alt-title></titles><periodical><full-title>Acta Ophthalmol (Copenh)</full-title></periodical><alt-periodical><full-title>Acta Ophthalmologica</full-title></alt-periodical><pages>235-42</pages><volume>70</volume><number>2</number><edition>1992/04/01</edition><keywords><keyword>Adult</keyword><keyword>Blood Glucose</keyword><keyword>Diabetes Mellitus, Type 1/physiopathology/*prevention &amp; control</keyword><keyword>Diabetic Retinopathy/*physiopathology</keyword><keyword>Female</keyword><keyword>Follow-Up Studies</keyword><keyword>Hemoglobin A, Glycosylated/analysis</keyword><keyword>Humans</keyword><keyword>Hypoglycemia/physiopathology/*prevention &amp; control</keyword><keyword>Intraocular Pressure</keyword><keyword>Light</keyword><keyword>Macula Lutea/*physiopathology</keyword><keyword>Male</keyword><keyword>Prospective Studies</keyword><keyword>Psychophysics</keyword><keyword>Retina/*physiopathology</keyword><keyword>*Visual Acuity</keyword></keywords><dates><year>1992</year><pub-dates><date>Apr</date></pub-dates></dates><isbn>0001-639X (Print)&#xD;0001-639X (Linking)</isbn><accession-num>1609574</accession-num><work-type>Research Support, Non-U.S. Gov&apos;t</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/1609574</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Frost-Larsen</Author><Year>1991</Year><RecNum>1643</RecNum><record><rec-number>1643</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">1643</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Frost-Larsen, K.</author></authors></contributors><auth-address>Sundhedsvidenskabelige Fakultet, Kobenhavns Universitet.</auth-address><titles><title>Macular recovery recorded by nyctometry in insulin-dependent diabetes mellitus</title><secondary-title>Acta Ophthalmol Suppl</secondary-title><alt-title>Acta ophthalmologica. Supplement</alt-title></titles><periodical><full-title>Acta Ophthalmol Suppl</full-title></periodical><alt-periodical><full-title>Acta Ophthalmologica. Supplement</full-title><abbr-1>Acta Ophthalmol. Suppl.</abbr-1><abbr-2>Acta Ophthalmol Suppl</abbr-2></alt-periodical><pages>1-39</pages><number>203</number><edition>1991/01/01</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Blood Glucose</keyword><keyword>Diabetes Mellitus, Type 1</keyword><keyword>Diabetic Retinopathy/metabolism/*physiopathology</keyword><keyword>Electroretinography</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Macula Lutea/*physiopathology</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Oscillometry</keyword><keyword>Pregnancy</keyword><keyword>Pregnancy in Diabetics/metabolism/physiopathology</keyword><keyword>Psychophysics</keyword><keyword>Reference Values</keyword><keyword>Risk Factors</keyword><keyword>Visual Acuity</keyword></keywords><dates><year>1991</year></dates><accession-num>1667959</accession-num><work-type>Comparative Study&#xD;Research Support, Non-U.S. Gov&apos;t&#xD;Review</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/1667959</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Yamazaki</Author><Year>1982</Year><RecNum>1650</RecNum><record><rec-number>1650</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">1650</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Yamazaki, H.</author><author>Adachi-Usami, E.</author><author>Chiba, J.</author></authors></contributors><titles><title>Contrast thresholds of diabetic patients determined by VECP and psychophysical measurements</title><secondary-title>Acta Ophthalmol (Copenh)</secondary-title><alt-title>Acta ophthalmologica</alt-title></titles><periodical><full-title>Acta Ophthalmol (Copenh)</full-title></periodical><alt-periodical><full-title>Acta Ophthalmologica</full-title></alt-periodical><pages>386-92</pages><volume>60</volume><number>3</number><edition>1982/06/01</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Child</keyword><keyword>Diabetic Retinopathy/*diagnosis</keyword><keyword>Differential Threshold</keyword><keyword>*Evoked Potentials, Visual</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Psychophysics</keyword><keyword>Vision, Ocular/*physiology</keyword></keywords><dates><year>1982</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>0001-639X (Print)&#xD;0001-639X (Linking)</isbn><accession-num>7136550</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/7136550</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Greenstein</Author><Year>1990</Year><RecNum>443</RecNum><record><rec-number>443</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">443</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Greenstein, V.</author><author>Sarter, B.</author><author>Hood, D.</author><author>Noble, K.</author><author>Carr, R.</author></authors></contributors><auth-address>Department of Ophthalmology, New York University Medical Center, New York 10016.</auth-address><titles><title>Hue discrimination and S cone pathway sensitivity in early diabetic retinopathy</title><secondary-title>Invest Ophthalmol Vis Sci</secondary-title><alt-title>Investigative ophthalmology &amp; visual science</alt-title></titles><periodical><full-title>Invest Ophthalmol Vis Sci</full-title></periodical><alt-periodical><full-title>Investigative Ophthalmology &amp; Visual Science</full-title></alt-periodical><pages>1008-14</pages><volume>31</volume><number>6</number><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Color Perception Tests</keyword><keyword>Color Vision Defects/*physiopathology</keyword><keyword>Diabetes Complications</keyword><keyword>Diabetes Mellitus/physiopathology</keyword><keyword>Diabetic Retinopathy/complications/*physiopathology</keyword><keyword>Humans</keyword><keyword>Macular Edema/complications/physiopathology</keyword><keyword>Middle Aged</keyword><keyword>Photoreceptors/*physiopathology</keyword><keyword>Sensory Thresholds</keyword><keyword>Visual Pathways/physiopathology</keyword></keywords><dates><year>1990</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>0146-0404 (Print)</isbn><accession-num>2354907</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=2354907 </url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Greenstein</Author><Year>1992</Year><RecNum>450</RecNum><record><rec-number>450</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">450</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Greenstein, V. C.</author><author>Shapiro, A.</author><author>Zaidi, Q.</author><author>Hood, D. C.</author></authors></contributors><auth-address>Department of Ophthalmology, New York University Medical Center, NY 10016.</auth-address><titles><title>Psychophysical evidence for post-receptoral sensitivity loss in diabetics</title><secondary-title>Invest Ophthalmol Vis Sci</secondary-title></titles><periodical><full-title>Invest Ophthalmol Vis Sci</full-title></periodical><pages>2781-90</pages><volume>33</volume><number>10</number><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Diabetes Mellitus, Type I/physiopathology</keyword><keyword>Diabetic Retinopathy/*physiopathology</keyword><keyword>Human</keyword><keyword>Middle Aged</keyword><keyword>Photic Stimulation</keyword><keyword>Photoreceptors/*physiopathology</keyword><keyword>Psychophysics</keyword><keyword>Sensory Thresholds</keyword><keyword>Support, Non-U.S. Gov&apos;t</keyword><keyword>Support, U.S. Gov&apos;t, P.H.S.</keyword></keywords><dates><year>1992</year><pub-dates><date>Sep</date></pub-dates></dates><accession-num>1526727</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=1526727</url></related-urls></urls></record></Cite><Cite><Author>Greenstein</Author><Year>1993</Year><RecNum>1639</RecNum><record><rec-number>1639</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">1639</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Greenstein, V. C.</author><author>Thomas, S. R.</author><author>Blaustein, H.</author><author>Koenig, K.</author><author>Carr, R. E.</author></authors></contributors><auth-address>Department of Ophthalmology, New York University Medical Center, New York.</auth-address><titles><title>Effects of early diabetic retinopathy on rod system sensitivity</title><secondary-title>Optom Vis Sci</secondary-title><alt-title>Optometry and vision science : official publication of the American Academy of Optometry</alt-title></titles><periodical><full-title>Optom Vis Sci</full-title></periodical><pages>18-23</pages><volume>70</volume><number>1</number><edition>1993/01/01</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Dark Adaptation</keyword><keyword>Diabetic Retinopathy/*physiopathology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Photoreceptor Cells/*physiopathology</keyword><keyword>Psychophysics</keyword><keyword>Sensory Thresholds</keyword><keyword>Visual Acuity</keyword><keyword>Visual Perception</keyword></keywords><dates><year>1993</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>1040-5488 (Print)&#xD;1040-5488 (Linking)</isbn><accession-num>8430004</accession-num><work-type>Research Support, Non-U.S. Gov&apos;t&#xD;Research Support, U.S. Gov&apos;t, P.H.S.</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/8430004</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Greite JH</Author><Year>1980</Year><RecNum>452</RecNum><record><rec-number>452</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">452</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Greite JH, Zumbansen HP, Adamczyk R</author></authors></contributors><titles><title>Visual field in diabetic retinopathy</title><secondary-title>Documenta Ophthalmol Proc Series</secondary-title></titles><periodical><full-title>Documenta Ophthalmol Proc Series</full-title></periodical><volume>26</volume><number>25-32</number><dates><year>1980</year></dates><urls></urls></record></Cite><Cite><Author>Adams</Author><Year>2012</Year><RecNum>684</RecNum><record><rec-number>684</rec-number><foreign-keys><key app="EN" db-id="e5tfs5v2rp5r0ge9sscvwr0msavadprtrf2t">684</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Adams, A. J.</author><author>Bearse, M. A., Jr.</author></authors></contributors><auth-address>School of Optometry, University of California at Berkeley, Berkeley, CA 94720-2020, USA. aadams@berkeley.edu</auth-address><titles><title>Retinal neuropathy precedes vasculopathy in diabetes: a function-based opportunity for early treatment intervention?</title><secondary-title>Clin Exp Optom</secondary-title><alt-title>Clinical &amp; experimental optometry : journal of the Australian Optometrical Association</alt-title></titles><periodical><full-title>Clin Exp Optom</full-title><abbr-1>Clinical &amp; experimental optometry : journal of the Australian Optometrical Association</abbr-1></periodical><alt-periodical><full-title>Clin Exp Optom</full-title><abbr-1>Clinical &amp; experimental optometry : journal of the Australian Optometrical Association</abbr-1></alt-periodical><pages>256-65</pages><volume>95</volume><number>3</number><edition>2012/04/14</edition><keywords><keyword>Diabetes Mellitus/physiopathology/*therapy</keyword><keyword>Diabetic Retinopathy/*prevention &amp; control</keyword><keyword>*Early Intervention (Education)</keyword><keyword>Electroretinography</keyword><keyword>Humans</keyword><keyword>Longitudinal Studies</keyword><keyword>Papilledema/prevention &amp; control</keyword><keyword>ROC Curve</keyword><keyword>Retina/physiopathology</keyword></keywords><dates><year>2012</year><pub-dates><date>May</date></pub-dates></dates><isbn>1444-0938 (Electronic)&#xD;0816-4622 (Linking)</isbn><accession-num>22497728</accession-num><work-type>Research Support, N.I.H., Extramural&#xD;Research Support, Non-U.S. Gov&apos;t&#xD;Review</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/22497728</url></related-urls></urls><electronic-resource-num>10.1111/j.1444-0938.2012.00733.x</electronic-resource-num><language>eng</language></record></Cite></EndNote>sD���y������K�	_ENREF_4sD���y������K�	_ENREF_4sD���y������K�	_ENREF_4sD���y������K�	_ENREF_4uD���y������K�
_ENREF_12uD���y������K�
_ENREF_13uD���y������K�
_ENREF_14uD���y������K�
_ENREF_13zD<EndNote><Cite><Author>Tonello</Author><Year>2008</Year><RecNum>699</RecNum><DisplayText><style face="superscript" font="Times New Roman">13-16</style></DisplayText><record><rec-number>699</rec-number><foreign-keys><key app="EN" db-id="e5tfs5v2rp5r0ge9sscvwr0msavadprtrf2t">699</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Tonello, M.</author><author>Costa, R. A.</author><author>Almeida, F. P.</author><author>Barbosa, J. C.</author><author>Scott, I. U.</author><author>Jorge, R.</author></authors></contributors><auth-address>Department of Ophthalmology, School of Medicine of Ribeirao Preto, Ribeirao Preto, Sao Paulo, Brazil.</auth-address><titles><title>Panretinal photocoagulation versus PRP plus intravitreal bevacizumab for high-risk proliferative diabetic retinopathy (IBeHi study)</title><secondary-title>Acta Ophthalmol</secondary-title><alt-title>Acta ophthalmologica</alt-title></titles><periodical><full-title>Acta Ophthalmol</full-title><abbr-1>Acta ophthalmologica</abbr-1></periodical><alt-periodical><full-title>Acta Ophthalmol</full-title><abbr-1>Acta ophthalmologica</abbr-1></alt-periodical><pages>385-9</pages><volume>86</volume><number>4</number><edition>2007/11/13</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Angiogenesis Inhibitors/*administration &amp; dosage</keyword><keyword>Antibodies, Monoclonal/*administration &amp; dosage</keyword><keyword>Antibodies, Monoclonal, Humanized</keyword><keyword>Cell Division/drug effects</keyword><keyword>Combined Modality Therapy</keyword><keyword>Diabetic Retinopathy/*drug therapy/*surgery</keyword><keyword>Female</keyword><keyword>Follow-Up Studies</keyword><keyword>Humans</keyword><keyword>Injections</keyword><keyword>Laser Coagulation/*methods</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Prospective Studies</keyword><keyword>Risk Factors</keyword><keyword>Treatment Outcome</keyword><keyword>Visual Acuity</keyword><keyword>Vitreous Body</keyword></keywords><dates><year>2008</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>1755-3768 (Electronic)&#xD;1755-375X (Linking)</isbn><accession-num>17995982</accession-num><work-type>Comparative Study&#xD;Randomized Controlled Trial&#xD;Research Support, Non-U.S. Gov&apos;t</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/17995982</url></related-urls></urls><electronic-resource-num>10.1111/j.1600-0420.2007.01056.x</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Fong</Author><Year>2003</Year><RecNum>685</RecNum><record><rec-number>685</rec-number><foreign-keys><key app="EN" db-id="e5tfs5v2rp5r0ge9sscvwr0msavadprtrf2t">685</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Fong, D. S.</author><author>Aiello, L.</author><author>Gardner, T. W.</author><author>King, G. L.</author><author>Blankenship, G.</author><author>Cavallerano, J. D.</author><author>Ferris, F. L., 3rd</author><author>Klein, R.</author></authors></contributors><titles><title>Diabetic retinopathy</title><secondary-title>Diabetes Care</secondary-title><alt-title>Diabetes care</alt-title></titles><periodical><full-title>Diabetes Care</full-title><abbr-1>Diabetes care</abbr-1></periodical><alt-periodical><full-title>Diabetes Care</full-title><abbr-1>Diabetes care</abbr-1></alt-periodical><pages>226-9</pages><volume>26</volume><number>1</number><edition>2002/12/28</edition><keywords><keyword>Diabetic Retinopathy/*epidemiology/*therapy</keyword><keyword>Humans</keyword><keyword>Practice Guidelines as Topic</keyword><keyword>Risk Factors</keyword></keywords><dates><year>2003</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>0149-5992 (Print)&#xD;0149-5992 (Linking)</isbn><accession-num>12502685</accession-num><work-type>Review</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/12502685</url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Mohamed</Author><Year>2007</Year><RecNum>881</RecNum><record><rec-number>881</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">881</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Mohamed, Q.</author><author>Gillies, M. C.</author><author>Wong, T. Y.</author></authors></contributors><auth-address>Centre for Eye Research Australia, University of Melbourne and Royal Victorian Eye and Ear Hospital, Melbourne, Australia.</auth-address><titles><title>Management of diabetic retinopathy: a systematic review</title><secondary-title>Jama</secondary-title></titles><periodical><full-title>JAMA</full-title></periodical><pages>902-16</pages><volume>298</volume><number>8</number><keywords><keyword>Angiogenesis Inhibitors/therapeutic use</keyword><keyword>Antihypertensive Agents/therapeutic use</keyword><keyword>Antilipemic Agents/therapeutic use</keyword><keyword>Blood Glucose</keyword><keyword>Blood Pressure</keyword><keyword>Diabetic Retinopathy/prevention &amp; control/*therapy</keyword><keyword>Glucocorticoids/therapeutic use</keyword><keyword>Humans</keyword><keyword>Laser Coagulation</keyword><keyword>Light Coagulation</keyword><keyword>Macular Edema/therapy</keyword><keyword>Vitrectomy</keyword></keywords><dates><year>2007</year><pub-dates><date>Aug 22</date></pub-dates></dates><isbn>1538-3598 (Electronic)</isbn><accession-num>17712074</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=17712074 </url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Parikh</Author><Year>2012</Year><RecNum>704</RecNum><record><rec-number>704</rec-number><foreign-keys><key app="EN" db-id="e5tfs5v2rp5r0ge9sscvwr0msavadprtrf2t">704</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Parikh, S. S.; Mehta, H. H.; Desai, B.I.</author></authors></contributors><titles><title>Advances in development of bevacizumab, a humanized antiangiogenic therapeutic monoclonal antibody targeting VEGF in &#xD;cancer cells</title><secondary-title>Int J Pharm Biomed Sci</secondary-title></titles><periodical><full-title>Int J Pharm Biomed Sci</full-title></periodical><pages>155-163</pages><volume>3</volume><number>4</number><dates><year>2012</year></dates><urls></urls></record></Cite></EndNote>`D<EndNote><Cite><Author>Bressler</Author><Year>2011</Year><RecNum>1584</RecNum><DisplayText><style face="superscript" font="Times New Roman">17, 18</style></DisplayText><record><rec-number>1584</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">1584</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bressler, N. M.</author><author>Beck, R. W.</author><author>Ferris, F. L., 3rd</author></authors></contributors><auth-address>Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</auth-address><titles><title>Panretinal photocoagulation for proliferative diabetic retinopathy</title><secondary-title>N Engl J Med</secondary-title><alt-title>The New England journal of medicine</alt-title></titles><periodical><full-title>N Engl J Med</full-title></periodical><alt-periodical><full-title>The New England Journal of Medicine</full-title></alt-periodical><pages>1520-6</pages><volume>365</volume><number>16</number><edition>2011/10/21</edition><keywords><keyword>Diabetes Mellitus, Type 2/complications</keyword><keyword>Diabetic Retinopathy/pathology/physiopathology/*surgery</keyword><keyword>Fundus Oculi</keyword><keyword>Humans</keyword><keyword>Light Coagulation/*methods</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Practice Guidelines as Topic</keyword><keyword>Retinal Neovascularization/pathology/*surgery</keyword><keyword>Risk Factors</keyword></keywords><dates><year>2011</year><pub-dates><date>Oct 20</date></pub-dates></dates><isbn>1533-4406 (Electronic)&#xD;0028-4793 (Linking)</isbn><accession-num>22010918</accession-num><work-type>Review</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/22010918</url></related-urls></urls><electronic-resource-num>10.1056/NEJMct0908432</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Krepler</Author><Year>2005</Year><RecNum>703</RecNum><record><rec-number>703</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">703</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Krepler, K.</author><author>Wagner, J.</author><author>Sacu, S.</author><author>Wedrich, A.</author></authors></contributors><auth-address>Department of Ophthalmology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. katharina.krepler@meduniwien.ac.at</auth-address><titles><title>The effect of intravitreal triamcinolone on diabetic macular oedema</title><secondary-title>Graefes Arch Clin Exp Ophthalmol</secondary-title></titles><periodical><full-title>Graefes Arch Clin Exp Ophthalmol</full-title></periodical><pages>478-81</pages><volume>243</volume><number>5</number><dates><year>2005</year><pub-dates><date>May</date></pub-dates></dates><accession-num>15586288</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=15586288</url></related-urls></urls></record></Cite></EndNote>uD���y������K�
_ENREF_17uD���y������K�
_ENREF_18uD���y������K�
_ENREF_19�	D<EndNote><Cite><Author>Mitchell</Author><Year>2012</Year><RecNum>1585</RecNum><DisplayText><style face="superscript" font="Times New Roman">19</style></DisplayText><record><rec-number>1585</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">1585</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Mitchell, P.</author><author>Annemans, L.</author><author>Gallagher, M.</author><author>Hasan, R.</author><author>Thomas, S.</author><author>Gairy, K.</author><author>Knudsen, M.</author><author>Onwordi, H.</author></authors></contributors><auth-address>Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, Hawkesbury Rd, Westmead, 2145 Australia. paul.mitchell@sydney.edu.au</auth-address><titles><title>Cost-effectiveness of ranibizumab in treatment of diabetic macular oedema (DME) causing visual impairment: evidence from the RESTORE trial</title><secondary-title>Br J Ophthalmol</secondary-title><alt-title>The British journal of ophthalmology</alt-title></titles><periodical><full-title>Br J Ophthalmol</full-title></periodical><alt-periodical><full-title>Br J Ophthalmol</full-title><abbr-1>The British journal of ophthalmology</abbr-1></alt-periodical><pages>688-93</pages><volume>96</volume><number>5</number><edition>2012/03/09</edition><keywords><keyword>Angiogenesis Inhibitors/*economics</keyword><keyword>Antibodies, Monoclonal, Humanized/*economics</keyword><keyword>Combined Modality Therapy</keyword><keyword>Cost-Benefit Analysis</keyword><keyword>Diabetic Retinopathy/complications/drug therapy/*economics</keyword><keyword>Drug Costs</keyword><keyword>Great Britain</keyword><keyword>Humans</keyword><keyword>Laser Coagulation</keyword><keyword>Macular Edema/complications/drug therapy/*economics</keyword><keyword>Markov Chains</keyword><keyword>Quality-Adjusted Life Years</keyword><keyword>Vision Disorders/*economics/etiology</keyword><keyword>Visual Acuity</keyword></keywords><dates><year>2012</year><pub-dates><date>May</date></pub-dates></dates><isbn>1468-2079 (Electronic)&#xD;0007-1161 (Linking)</isbn><accession-num>22399690</accession-num><work-type>Research Support, Non-U.S. Gov&apos;t</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/22399690</url></related-urls></urls><custom2>3329632</custom2><electronic-resource-num>10.1136/bjophthalmol-2011-300726</electronic-resource-num><language>eng</language></record></Cite></EndNote>uD���y������K�
_ENREF_11 	D<EndNote><Cite><Author>Adams</Author><Year>2012</Year><RecNum>684</RecNum><DisplayText><style face="superscript" font="Times New Roman">11</style></DisplayText><record><rec-number>684</rec-number><foreign-keys><key app="EN" db-id="e5tfs5v2rp5r0ge9sscvwr0msavadprtrf2t">684</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Adams, A. J.</author><author>Bearse, M. A., Jr.</author></authors></contributors><auth-address>School of Optometry, University of California at Berkeley, Berkeley, CA 94720-2020, USA. aadams@berkeley.edu</auth-address><titles><title>Retinal neuropathy precedes vasculopathy in diabetes: a function-based opportunity for early treatment intervention?</title><secondary-title>Clin Exp Optom</secondary-title><alt-title>Clinical &amp; experimental optometry : journal of the Australian Optometrical Association</alt-title></titles><periodical><full-title>Clin Exp Optom</full-title><abbr-1>Clinical &amp; experimental optometry : journal of the Australian Optometrical Association</abbr-1></periodical><alt-periodical><full-title>Clin Exp Optom</full-title><abbr-1>Clinical &amp; experimental optometry : journal of the Australian Optometrical Association</abbr-1></alt-periodical><pages>256-65</pages><volume>95</volume><number>3</number><edition>2012/04/14</edition><keywords><keyword>Diabetes Mellitus/physiopathology/*therapy</keyword><keyword>Diabetic Retinopathy/*prevention &amp; control</keyword><keyword>*Early Intervention (Education)</keyword><keyword>Electroretinography</keyword><keyword>Humans</keyword><keyword>Longitudinal Studies</keyword><keyword>Papilledema/prevention &amp; control</keyword><keyword>ROC Curve</keyword><keyword>Retina/physiopathology</keyword></keywords><dates><year>2012</year><pub-dates><date>May</date></pub-dates></dates><isbn>1444-0938 (Electronic)&#xD;0816-4622 (Linking)</isbn><accession-num>22497728</accession-num><work-type>Research Support, N.I.H., Extramural&#xD;Research Support, Non-U.S. Gov&apos;t&#xD;Review</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/22497728</url></related-urls></urls><electronic-resource-num>10.1111/j.1444-0938.2012.00733.x</electronic-resource-num><language>eng</language></record></Cite></EndNote>uD���y������K�
_ENREF_20�D<EndNote><Cite><Author>Harrison</Author><Year>2011</Year><RecNum>1599</RecNum><DisplayText><style face="superscript" font="Times New Roman">11, 21</style></DisplayText><record><rec-number>1599</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">1599</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Harrison, W. W.</author><author>Bearse, M. A., Jr.</author><author>Schneck, M. E.</author><author>Wolff, B. E.</author><author>Jewell, N. P.</author><author>Barez, S.</author><author>Mick, A. B.</author><author>Dolan, B. J.</author><author>Adams, A. J.</author></authors></contributors><auth-address>School of Optometry, Group in Vision Science, University of California Berkeley, Berkeley, California, USA. wharri@midwestern.edu</auth-address><titles><title>Prediction, by retinal location, of the onset of diabetic edema in patients with nonproliferative diabetic retinopathy</title><secondary-title>Invest Ophthalmol Vis Sci</secondary-title><alt-title>Investigative ophthalmology &amp; visual science</alt-title></titles><periodical><full-title>Invest Ophthalmol Vis Sci</full-title></periodical><alt-periodical><full-title>Investigative Ophthalmology &amp; Visual Science</full-title></alt-periodical><pages>6825-31</pages><volume>52</volume><number>9</number><edition>2011/07/12</edition><keywords><keyword>Adult</keyword><keyword>Age of Onset</keyword><keyword>Aged</keyword><keyword>Diabetes Mellitus, Type 2/blood/*complications/epidemiology</keyword><keyword>Diabetic Retinopathy/*complications/diagnosis/epidemiology</keyword><keyword>Diagnosis, Differential</keyword><keyword>Disease Progression</keyword><keyword>Electroretinography</keyword><keyword>Female</keyword><keyword>Fluorescein Angiography</keyword><keyword>Follow-Up Studies</keyword><keyword>Fundus Oculi</keyword><keyword>Hemoglobin A, Glycosylated/metabolism</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Papilledema/diagnosis/*epidemiology/etiology</keyword><keyword>Predictive Value of Tests</keyword><keyword>Retina/*pathology/physiopathology</keyword><keyword>Risk Assessment/*methods</keyword><keyword>Risk Factors</keyword><keyword>Tomography, Optical Coherence</keyword><keyword>United States/epidemiology</keyword><keyword>Young Adult</keyword></keywords><dates><year>2011</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>1552-5783 (Electronic)&#xD;0146-0404 (Linking)</isbn><accession-num>21743017</accession-num><work-type>Comparative Study&#xD;Research Support, N.I.H., Extramural</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/21743017</url></related-urls></urls><custom2>3176012</custom2><electronic-resource-num>10.1167/iovs.11-7533</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Adams</Author><Year>2012</Year><RecNum>684</RecNum><record><rec-number>684</rec-number><foreign-keys><key app="EN" db-id="e5tfs5v2rp5r0ge9sscvwr0msavadprtrf2t">684</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Adams, A. J.</author><author>Bearse, M. A., Jr.</author></authors></contributors><auth-address>School of Optometry, University of California at Berkeley, Berkeley, CA 94720-2020, USA. aadams@berkeley.edu</auth-address><titles><title>Retinal neuropathy precedes vasculopathy in diabetes: a function-based opportunity for early treatment intervention?</title><secondary-title>Clin Exp Optom</secondary-title><alt-title>Clinical &amp; experimental optometry : journal of the Australian Optometrical Association</alt-title></titles><periodical><full-title>Clin Exp Optom</full-title><abbr-1>Clinical &amp; experimental optometry : journal of the Australian Optometrical Association</abbr-1></periodical><alt-periodical><full-title>Clin Exp Optom</full-title><abbr-1>Clinical &amp; experimental optometry : journal of the Australian Optometrical Association</abbr-1></alt-periodical><pages>256-65</pages><volume>95</volume><number>3</number><edition>2012/04/14</edition><keywords><keyword>Diabetes Mellitus/physiopathology/*therapy</keyword><keyword>Diabetic Retinopathy/*prevention &amp; control</keyword><keyword>*Early Intervention (Education)</keyword><keyword>Electroretinography</keyword><keyword>Humans</keyword><keyword>Longitudinal Studies</keyword><keyword>Papilledema/prevention &amp; control</keyword><keyword>ROC Curve</keyword><keyword>Retina/physiopathology</keyword></keywords><dates><year>2012</year><pub-dates><date>May</date></pub-dates></dates><isbn>1444-0938 (Electronic)&#xD;0816-4622 (Linking)</isbn><accession-num>22497728</accession-num><work-type>Research Support, N.I.H., Extramural&#xD;Research Support, Non-U.S. Gov&apos;t&#xD;Review</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/22497728</url></related-urls></urls><electronic-resource-num>10.1111/j.1444-0938.2012.00733.x</electronic-resource-num><language>eng</language></record></Cite></EndNote>uD���y������K�
_ENREF_11uD���y������K�
_ENREF_21uD���y������K�
_ENREF_22uD���y������K�
_ENREF_23LD<EndNote><Cite><Author>Hood</Author><Year>2002</Year><RecNum>538</RecNum><DisplayText><style face="superscript" font="Times New Roman">23</style></DisplayText><record><rec-number>538</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">538</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hood, D. C.</author><author>Frishman, L. J.</author><author>Saszik, S.</author><author>Viswanathan, S.</author></authors></contributors><auth-address>Department of Psychology, 406 Schermerhorn Hall, Columbia University, New York, NY 10027, USA. don@psych.columbia.edu</auth-address><titles><title>Retinal origins of the primate multifocal ERG: implications for the human response</title><secondary-title>Invest Ophthalmol Vis Sci</secondary-title></titles><periodical><full-title>Invest Ophthalmol Vis Sci</full-title></periodical><pages>1673-85</pages><volume>43</volume><number>5</number><keywords><keyword>Action Potentials/drug effects/physiology</keyword><keyword>Adult</keyword><keyword>Aminobutyric Acids/pharmacology</keyword><keyword>Animal</keyword><keyword>Comparative Study</keyword><keyword>Electroretinography/*methods</keyword><keyword>Human</keyword><keyword>Interneurons/physiology</keyword><keyword>Macaca mulatta</keyword><keyword>Middle Age</keyword><keyword>N-Methylaspartate/pharmacology</keyword><keyword>Photoreceptors, Vertebrate/physiology</keyword><keyword>Retina/drug effects/*physiology</keyword><keyword>Retinal Ganglion Cells/physiology</keyword><keyword>Support, Non-U.S. Gov&apos;t</keyword><keyword>Support, U.S. Gov&apos;t, P.H.S.</keyword><keyword>Tetrodotoxin/pharmacology</keyword><keyword>gamma-Aminobutyric Acid/pharmacology</keyword></keywords><dates><year>2002</year><pub-dates><date>May</date></pub-dates></dates><accession-num>11980890</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=11980890</url></related-urls></urls></record></Cite></EndNote>ND<EndNote><Cite><Author>Fortune</Author><Year>1999</Year><RecNum>378</RecNum><DisplayText><style face="superscript" font="Times New Roman">24, 25</style></DisplayText><record><rec-number>378</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">378</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Fortune, B.</author><author>Schneck, M. E.</author><author>Adams, A. J.</author></authors></contributors><auth-address>Group in Vision Science, School of Optometry, University of California Berkeley, USA. bfortune@discoveriesinsight.org</auth-address><titles><title>Multifocal electroretinogram delays reveal local retinal dysfunction in early diabetic retinopathy</title><secondary-title>Invest Ophthalmol Vis Sci</secondary-title></titles><periodical><full-title>Invest Ophthalmol Vis Sci</full-title></periodical><pages>2638-51</pages><volume>40</volume><number>11</number><keywords><keyword>Adult</keyword><keyword>Diabetes Mellitus, Insulin-Dependent/*physiopathology</keyword><keyword>Diabetes Mellitus, Non-Insulin-Dependent/*physiopathology</keyword><keyword>Diabetic Retinopathy/classification/*diagnosis/physiopathology</keyword><keyword>Electroretinography</keyword><keyword>Female</keyword><keyword>Fundus Oculi</keyword><keyword>Human</keyword><keyword>Male</keyword><keyword>Middle Age</keyword><keyword>Retina/pathology/*physiopathology</keyword><keyword>Sensitivity and Specificity</keyword><keyword>Support, Non-U.S. Gov&apos;t</keyword><keyword>Support, U.S. Gov&apos;t, P.H.S.</keyword></keywords><dates><year>1999</year><pub-dates><date>Oct</date></pub-dates></dates><accession-num>10509661</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=10509661</url></related-urls></urls></record></Cite><Cite><Author>Bearse</Author><Year>2006</Year><RecNum>110</RecNum><record><rec-number>110</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">110</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bearse, M. A., Jr.</author><author>Adams, A. J.</author><author>Han, Y.</author><author>Schneck, M. E.</author><author>Ng, J.</author><author>Bronson-Castain, K.</author><author>Barez, S.</author></authors></contributors><auth-address>School of Optometry and Vision Science Program, University of California, Berkeley, Berkeley, CA 94720-2020, USA.</auth-address><titles><title>A multifocal electroretinogram model predicting the development of diabetic retinopathy</title><secondary-title>Prog Retin Eye Res</secondary-title><alt-title>Progress in retinal and eye research</alt-title></titles><periodical><full-title>Prog Retin Eye Res</full-title></periodical><alt-periodical><full-title>Progress in Retinal and Eye Research</full-title><abbr-1>Prog Retin Eye Res</abbr-1></alt-periodical><pages>425-48</pages><volume>25</volume><number>5</number><keywords><keyword>Diabetic Retinopathy/*diagnosis/physiopathology</keyword><keyword>Electroretinography/methods</keyword><keyword>Humans</keyword><keyword>Prognosis</keyword><keyword>Retina/*physiopathology</keyword></keywords><dates><year>2006</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>1350-9462 (Print)</isbn><accession-num>16949855</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16949855 </url></related-urls></urls><language>eng</language></record></Cite></EndNote>uD���y������K�
_ENREF_24uD���y������K�
_ENREF_25D<EndNote><Cite><Author>Bearse</Author><Year>2006</Year><RecNum>110</RecNum><DisplayText><style face="superscript" font="Times New Roman">21, 25</style></DisplayText><record><rec-number>110</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">110</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bearse, M. A., Jr.</author><author>Adams, A. J.</author><author>Han, Y.</author><author>Schneck, M. E.</author><author>Ng, J.</author><author>Bronson-Castain, K.</author><author>Barez, S.</author></authors></contributors><auth-address>School of Optometry and Vision Science Program, University of California, Berkeley, Berkeley, CA 94720-2020, USA.</auth-address><titles><title>A multifocal electroretinogram model predicting the development of diabetic retinopathy</title><secondary-title>Prog Retin Eye Res</secondary-title><alt-title>Progress in retinal and eye research</alt-title></titles><periodical><full-title>Prog Retin Eye Res</full-title></periodical><alt-periodical><full-title>Progress in Retinal and Eye Research</full-title><abbr-1>Prog Retin Eye Res</abbr-1></alt-periodical><pages>425-48</pages><volume>25</volume><number>5</number><keywords><keyword>Diabetic Retinopathy/*diagnosis/physiopathology</keyword><keyword>Electroretinography/methods</keyword><keyword>Humans</keyword><keyword>Prognosis</keyword><keyword>Retina/*physiopathology</keyword></keywords><dates><year>2006</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>1350-9462 (Print)</isbn><accession-num>16949855</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16949855 </url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Harrison</Author><Year>2011</Year><RecNum>1599</RecNum><record><rec-number>1599</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">1599</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Harrison, W. W.</author><author>Bearse, M. A., Jr.</author><author>Schneck, M. E.</author><author>Wolff, B. E.</author><author>Jewell, N. P.</author><author>Barez, S.</author><author>Mick, A. B.</author><author>Dolan, B. J.</author><author>Adams, A. J.</author></authors></contributors><auth-address>School of Optometry, Group in Vision Science, University of California Berkeley, Berkeley, California, USA. wharri@midwestern.edu</auth-address><titles><title>Prediction, by retinal location, of the onset of diabetic edema in patients with nonproliferative diabetic retinopathy</title><secondary-title>Invest Ophthalmol Vis Sci</secondary-title><alt-title>Investigative ophthalmology &amp; visual science</alt-title></titles><periodical><full-title>Invest Ophthalmol Vis Sci</full-title></periodical><alt-periodical><full-title>Investigative Ophthalmology &amp; Visual Science</full-title></alt-periodical><pages>6825-31</pages><volume>52</volume><number>9</number><edition>2011/07/12</edition><keywords><keyword>Adult</keyword><keyword>Age of Onset</keyword><keyword>Aged</keyword><keyword>Diabetes Mellitus, Type 2/blood/*complications/epidemiology</keyword><keyword>Diabetic Retinopathy/*complications/diagnosis/epidemiology</keyword><keyword>Diagnosis, Differential</keyword><keyword>Disease Progression</keyword><keyword>Electroretinography</keyword><keyword>Female</keyword><keyword>Fluorescein Angiography</keyword><keyword>Follow-Up Studies</keyword><keyword>Fundus Oculi</keyword><keyword>Hemoglobin A, Glycosylated/metabolism</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Papilledema/diagnosis/*epidemiology/etiology</keyword><keyword>Predictive Value of Tests</keyword><keyword>Retina/*pathology/physiopathology</keyword><keyword>Risk Assessment/*methods</keyword><keyword>Risk Factors</keyword><keyword>Tomography, Optical Coherence</keyword><keyword>United States/epidemiology</keyword><keyword>Young Adult</keyword></keywords><dates><year>2011</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>1552-5783 (Electronic)&#xD;0146-0404 (Linking)</isbn><accession-num>21743017</accession-num><work-type>Comparative Study&#xD;Research Support, N.I.H., Extramural</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/21743017</url></related-urls></urls><custom2>3176012</custom2><electronic-resource-num>10.1167/iovs.11-7533</electronic-resource-num><language>eng</language></record></Cite></EndNote>uD���y������K�
_ENREF_21uD���y������K�
_ENREF_25B�Dd�,�())�Z�
�
C�6A��JBD_Fig_1_tiff��b������{B_���\>)�p�b�,n�h�����{B_���\>)��PNG


IHDR�x�}��sRGB���gAMA���a	pHYs
|
||wtEXtSoftwareKruwo soft(�a���IDATx^�w�>������������	�`qB$Ĉ{�ww��-�����$�t*}���	}�Yw1P��j׮��[����?����ò��҂��r@���*T�`p��������*�+�ԟ��*T�P9�r@+���4�˗�?�*T�P9�r@�.��x4i�yy�+�ԟ��*T�P9�r����X��ƠjH*T�P9�r@�>��**T�P9�r@�a��a�&)�*T�P9�r@�T�A���*T�0�Uc0�#U�T9�r@���*T�A�T�P9�r@���P5�<R�J�*T�P9�r@�T�A���*T�0�Uc0�#U�T9�r@���*T�A�T�P9�r@���P5�<R�J�*T�P9�r@�T�A���*T�0�Uc0�#U�T9�r@���*T�A�T�P9�r@���P5�<R�J�-��**s22bcb
srk�N�H���*-�����b���3�O���j��Pץr@�~���1��N9P��7}ڴ�S�Λ=gРAv[�ˢ�����|��q�f��ҹsRB�����cǎ�{P�_�^�*T|�P5���e]]�&h�A~vN�6mr22�f��۰�C����g�]�z��?��\��h]�6}�L��P9�q@�ԋO�ʁ���~}��DE��u��Օ�
rr:u옒����6s��Ӧ[�Y�vQ��U9�rP5��P9�r��07�k�.��a���>P�#4�^={����EE��y꽩r@�w�UcP_�*�6�ڮ\iN݃�z��JK������={�x{�W��p�*h���Z���9���ٹS���4�^�ׯ_zJ�7CI��!80P�4U�P9�j�k����Ȯ����7.��è�#C����,�����[���(u�*T��Ơj*�_D��!E":2��
W��O�:��2*<��o�U�7�M�?�*�s��z��N9��s�րd�hcC�(��G�>|���6�/�6�=�?�*T��z��N9����C�Ғ��;��������s~v�zK�P9�r�‪1|���zT��.+�,)��P���r,�233RR�_nf&��8/����������9�j�Ơr��p9�5�Ҋ����"��\��_�������?+--35551?�!��	 �4s��A
����1
�0%U�_u�-����r^��'���s�R)'O5�줸8!o�l}ӓ��^`�0iP���O��Sဪ1����r_���%�vG�IhiII��ONH�퍗t������{��̔��t�M��C���Z�?�*�UcPo%�����a�GQi8�RR��
�&�Kn6H��Û
��6�r㗑�������GFƷ��_��腟��斖����
� ~�d5���P��ZE�a�d�䀪1�O倬���AQnnvzzjRbR|B���R�8%qo�/ 5�?B
dPZP���^@�0+���"�P�("e�����dg�>�1�D&��Vq0
��)獩��r�{怪1�Z|Ϣ��������0�Q?�7A��r��
��Tx+
�s�T�[����[���s�US"0s��ˌ�d�*�R��
�7;-
|���{6�6S9 -T�AZ��7�|�~?���Ŗ��;;=C��@��B9�G<��-�El���2�F��E�����̲�x�25�R��T��UcP5�9PZX�`��%�W���%�
���	_���D��y|=7x@�|�#/��m_�]�y�*�XxC�h��A\?݋��D\�/-���@�R��P��b8�j���-FVx,�q;��ݻ�����7r�|(��.Ue�Hd���Ɠ����H
�}�(7��-P�2XF���`n��l���2l����t��B�q�eӢ�~\tL�v�w��o�϶�թ�QT��E�
�*L����������е�v���ۯ��KH9��1|�V���g礲s�S�~��<�)V�ef���;�Fan.���CC)���yyzBJ��JG��UcP5�9�':
����_�>>�^����ӎ;������`|6�C9�ka����9Oba�P�rn4e�(F�*�6���b��H(��ʆILΩ�2ֻ�ںM�6��9��;���!Q����Uc���ne�j(ed�luy͛7�ʕ+���������vh�������ƦR�a
����|�v'%�jʟBN�A����ˀ�����^Zl�3 ��,��ȿ2xp��(��:
�怪1��8�c�f�z�кU������R]��|�Ν�R7ڴ�S�iFtBfj
��Ŕ��O���Ĥo.���6@#X*��#ۥ�0J�3".����>�{�W�ũD,]�T�i�Ծ+����A$�mڸ�g�������cM]���gO��\��j�R��ކd61��JN��H��z�����̊H�@L	l�4�`j��I(J��0`u�n��矧L������P5VWo���UeeA��Æ
�
S�L�t�]�����{���/mۢc�= �ƽ��Y���J�z�
�Kh��.��Z�ܒ���	j"O��I�sb��@����0��>>0�qR�ƫ,-S���ܜ�G�E\��1�O�ëS�?��#u���W6����}`�>*:�ChP��b͞�M�z���={�<wzyzPP��)�-M�T����"�7��D���^�R���`k휷�@u��a��%�*8�"�MJ>8���T�J=����eK����'\=�Z�r�������@��v�긱c�[�n�f�gN���Rp��*
s�����ܠm�ݠ~�ɶAFh��U?�n=n�5�,Â���pU@x�#'7/Z(PW �#�y��UAN���mZP5Uc���B�-[�K恾}�\���
�G��e���4k�,�Iz�(+���y��� T��ŅҊ�f��Q�IwǸ�a`���j�oӦ[��1��;v$%脬F%29e�
�^w��IDu�&նm[��n�0.���M����4��h�p��pw�ٳ'u��IKK���#?��ן��'vO�֭�=tȐ��l)VK20u�
�OKC'��{��y;CIڰ~�sSi�H��1c:$��>x��W�֭�4���A���.W��2�q��,��@y���ݷo�A�1�F��UcP5@.@p`�Q#����_~Y�v��g<�z4�ʊ�a䌉���|�)銊tc^f�������h��>��pزE��A�aV���R!�N��M��y��yJJ����������'*
(�yY���>!`�E���y�.z�o��&�uA��ѣ}v�R�xR��j�Ơ��(7~<u���6(�(6��������
\HA���$���D=��x*�C�B�cnj1x5cz[���M��Caa��� ���W܉+�ͣt�^={��{��Ǐ��W*v��S_�=��c�'\B0����R�;t�T{�e��SR5��_F�	j�V�;{6,
�}�+U>�{'���I�]�[�m�(�:kk~�..;�	{�px4�`��	�[�!wyxt�ؑ��K��u��&���d�޵K�\�����0a�"�N
Ƨ!���ɓ'?|�@�x�}�����%ĵ�+%E0.v����Btٮ���&o��fL��R Eo�Ŏ;��K����ƠjL����]�o�жmڬ47��ԺM���t
Oz��U�?L�UV!a���lI|fg�3���YY�f��z�BipqtT�{��5�f6�*~��.P?�Q�L!�4-*>��gO��p�fgg�����@/ℰD=(Ԁ����)�ܿ�2)z{��.\�����*�UcPOB3썋�����e�^�Պ�,�q��5���0�*B��r@�CYd�UXp0���p�e�ռ�`Npt���Ο1}Z�b
}9::��D�5����̴4
d������y~]W׫W/�CgooG�D���8�.��	�����IL�����C�q�0� �U�mL��Ơj�8�@�S�;w�����^r7�^<�'K�.m�������D��]A�qH�(���;"Ԗ.Y"�R�v��	�x|u1k����M�0�F���m��Ë.4b�Ȩ�ʺ�|��l���_�F-
����fLn�(��B��@�|�1M��m��(P��v�5}��I��B8�j��ЌO�n��wﰿF%m�2٭[7`�"e�<6�v���+��v�]73%E�DE��(�+�lWggy��JTH8�@Y�aC��}2�E�l�����CCՓy���H�`�������3�=s�4Ҁ!?O�����U�����)�z�[��~�r5_�B���d�#u8�r@�T��`������G��^v��x�� @������xr32�@;�ge��Ӿp�|q?��R�CHG����EG�61z `L�6���:U8�d�۾m凂,�`�[8߿��\e	:�Z��d�b�L��5(��:�Z@�S�ӰA�c�1q�6��CC�!uDer@�T���DK]"��ռ/S):��^A4;�����ത$�
�t@�g�+�o��%���6Tk�>�=�x�6ج'�(
.)'��w��!Ru�ԩ'F7����d2i ;v��K[�������O���ߛ��\D�e��Q�:�3X5���K���;�7mT�����q�)W�XJ�1��
�5+�>��?�����B] �0����D!X��ё�3ƣ%,
�i����5]%���6n��7U:�NR%W��	� Z��/mlL?�����K>�ݻ;���ӻ<=��(`�zj��D�#0)�JS�$�`�h�U��r@����$�6I�o�`��u���XW�@:ׯ\*���}������l��{���-�E,�tnf��*
t{h3��$����bw�eJ1C�Ǫ�TRIzZ*��$�;<;=<(u%����{�H����Ҫ�&��	�IjLhN�$Ŏ�4M��ƠjL��B�3{���*Wj߿�z�Rvz�ֻ5~O̦
��v�ԯ+��lٴ�}{��Ϝ�N6��p���q�az���̊j3z�H�OHtUe��vo��$�קOx��U
�d,�%�:�2����"�rȾ}fF�z��A"kW�+�v�7�j�=Q���*����4i�D��5E���109����8t�P�w��-���_�;�_O�ؙ�G��4j�(����K��P��;�Hw.��D��4'{Q�~����Q�F�f�O��>�bA<�Βŋ0+hSP�-��W/Q������.�V�P�ѣGS�Z��::<\W6���w�N5!7��%KKѥE%h�P5UcЂ�عs'D�I}�j�p�?�_U�����-�ɾw����׿uvr��������!D�WWW~u�7��f��H�z��i��]�tꆈwVdxx�ΝE�Md��cOyL���Md�<yBy���Chh(���& �1�Ԥ$� ��DŽq�}}t��<w�X8��f�6o�ȃ�j���UcP5&�aЯo_�&/\���ߟ?}R^\���LٛPVT��ޝ�jD�!�2..��S&O��:��J<w�6���m�4 ��{��&L�h��it߶������Ш�(�c��j��͋`�i������s�H2=ʁ���4L����O�~~�]ۊg���(�!"4d���ݺ6�Ҕ�M�D�ۭv���ƠjL Eph�e�� �={��
��t%�U���FSW 'v��%��`(a�K��tJb"]L��s��Z#��龝S�'׵�q���c�(/2|�p�xd$d�߿~Y�x1�Va�y�.�N�3ؗ6?��GC��bOd������+��������KK倪1��,\0��$��0��Zu�Խ{ϝ>������`ff�T{q�K��`�mlا\֔�;9:ʐ�A-m��E�8�|.����p�|�m�����JF�?���[,EH�fP��b��j#�7�.��֯_ߥ�î�Uu	�;{�K����	�q<�C��R9�j��ʖ*
�<w�XV��z��'�k^��P}�쩓\	R�m���l��$XШ��7n\n��%�&[[����|Eia����A|�J]@�h~�dOO/��Q
?�pV[��MسG� �Q)<Ȳ�p����d���F�P5Uc���dJc@����G����b7`^f��7���+���2Y^�27k�����j��/�3Lr�{��t�{j����QxH���A��P�s��y󺎷 ��1&:Z���z��!A�5������k%26�Ӈ,P6"���N8�j�Ơ���q��U@�ioϏ����L�,�͹���u��!!���}`�7n�
#
?��n,�l������
�z
�K�p�����N�:E�q@�X�v��N�B����F���ߘѣ=v��e�|��ƌ%��	~�)4oPl�-��Ơj�90v�X\@�������4���N9,� r��eᗲt����%#G��ܶn5��X���� 8#̖-��?,)kEk�Vs�Z1X��TcV,WǦ���
TWa�&�-\��(�I���Z�S�.D���1h�p����#�9��uia�f�#�)߾����>E�gbݕ�i�iX��<�({(�X<��k�f�*���(K�����Yv�s}�Js���LJz)}}}l(�8�Hg��,WDzS���h7�.\ r���EyfT"-��Ơj�9�a�z\^[�nro��ܩ�0$0����RQ-BtxL��k�f4�tzr2�����ٳ�
s�N���y��iNF&.bW����O?����.��)D�5��֍����0N�:9��W����T�����b�:u!�p@�T�A;�܂�fʔ)��ΗO�h͜�*+�M�`�effoIy��47�g ~����%9�+���x�ر��HګC���6m�p�����
c5x��|pqr�46���Zk+��
�{DyfT"-��Ơj�9�\s��q�´p��Z3���ܗ�Cp������C�1���
Օ�+y��$''��A���ɓ'�f�����5�
ޞ�cG7�_�C���ԩ��Ơj�9�"��-s�j-���
7���qy�%%�9qL�k=ZX������ڵ�m��_Td${�4J��|�˕��!Lħ����k�RI��~���Q��$���1h�������=�Q�YY������/�>JjZ�gx��ANע���9p�L%�X��fta*X
O�gC�%�$2,�k�x�Z�S��E���1���q�!���]	(�s�Nh3-$]�r��?�0HA�/�?��d���!�gϊ%<ё9%��Ə�4Co��a��3��ȱcLj�ƨDZT�A�tr�m�6�
�-�c��?�x�����j����w�na]d�տ�֭�B3u2p�ѣG2����ɓ&���Z���`�,��x�"d��Ҍ��Z�S��E���1��@lL��	���y��UT$'�3ԅ��T��_p�ӵ˾�
h�6T��x���x���-P��(�F�D�>��}}4#"w�x�9R��-h����T�P5�H��@Eq	©���'�Um�ֵ��gd\FpL�=yBHm�w:|F��n��]T
��ݡ�" @��E���E��1�jlt�ͺ��~�M}�ի��R���Ơj:9��^={�m��]}=y��䰿��q!�1/+�C�[��`����/Y���p�s��ƕ7���W/iyI�;զ��ޞ��
��
�H�D|���R倪1�*[@c���N��o�g�A3�4-ܺ~M�G=7����ר���9�`�B�o�q�z�B!Lp��Q##4�/���--���FG���Uc`�^
����֟@:��>�1h+>!�."�_�����3�TW}��޸�29zdd�B�huRs�v���֙���J�N�;u�h�~�fD�
�[HfZ�q/!���.����R!DԾ�P��(�a�]�t�I�^��j�o��%V����BYQ�f������ve��)��t���9q`ǎJ?�|9�H��={���g稰�_���@YQ��>���t
O��;��c5�qڪ� �ư':U|z��A{�٬]WS^a�m�=t`@ֲl钼�,��ʓ�޼V�}}��%y�]u�s`��U%��66F��	t��a�Vf�K��W,G��M��5*�ڬ_l{r�P�`+
*�P�Hq@��jP`Q.���}�Сz��Y�f�V�ɉ]Zr��%�S�Ey���Jz��&�X3e���D�@ff&o9���2˓R�����DD0>�os5777��*;=��zd���Yiiզ����Q5A���L�L[��_��|��M�D���ĸMғ�^>}*�3�;}�
�����o�</]��[Hd�����!�����L̆�؊S
�ٵ�_��|��5�p�=#�”���T���Ɛ�����j�^���3���9�f�@E8�
1P��?���R����?�!w���T8p���?�!�>yl�lݺ���M����99��)��_�d	�gKK���>�46vϼy�����ff	���_�rUc�1 (:<���@�>}���+��X~V6�@N���nj���V��X���I���NJ���x�	m��Y35=��+67U\LL�(&���Q���jm�˻w�g#F���_�_��;Y�8��J`Vq~�՚5ݻu��?��
���M����дd�'".&:8(���m�.�v�e�T"J��5�}�j��@���Хs�ݻ5�V*�础������*ƌs��=]��7�_�TWϜ��ck�2eJzJ�^��A�1��]`T���3{6Β'��Iz�WYU�ቀ|D��AC�5k����&'K�_-�&
""�_s<����㒥�7u�T,!;�v�II�ϗ�P�grϞ=߼��!�uٻ7��rҲ}�vl֡�%Co(�΁SR!/Yjb��)S(��ܺu``BF�l�K]���=Z�Q9���)'3S!�U�4T�A���5?+��f�g�.bF������@��H���lӦ�£���2�]��O�ހ��z{y���r���7����;��O�W����h۶�3g�Mf\��"�{iQ�2M[v6+=#I����pSU����HEy̫x���Ǡ?h}�*����]�fw2���Lc�*-ݱ}��a�X�?�rc���e��������dMS$*QaJEyy���޽�l�x%����"��|'D����� ^��1<|p������.]��/�c�{�
�:)���Y#M	�G�aÆ
2�A�!zt�`��Z���B�!;!�`Μوǒqmzzx�(d�����qq���,�Q`�eKA�	����C��0јȨ�VVl�Ƌ~>)����a�C���'�3�Ug���1�8~��W̰��HQױ��<�x�$ڵC*���H��2tD�ǎkDllleE��Z�V>2�߿*Y&.\h�һW/���-).�����1?;[� A�+zРo��|��a����Cf˖�j�k��4,Y�8$0��x�v�*J��n_�3�)I��QRS.0YNz�&�sq^CP�Λ��yyy�xD%%���)��F����`�|����'N$&%�~_|x5�cC>�=ZR)N�xF��	�9��`kԼ%���P89:�Q��_?Kb[B.XNNN���u1
W4N���s���||�6����Y3f�lj��$�`jb�e��Z�5ЙOTQ��t��nX2�L(�A�=j��55�A�-[�l���{����Ў17ᏺ�~��GS�{;;�5���4�%��Rs3��Ln���_����JK���OIw
h�gϜ���ޭ[W]ۇ�Hᐠ ӭ���`4�5�
PE�����_|w�*�*��5��Ƭ�}��0B�@�x5xРϟ>JzVE$�z�Z󚃄kj�鈋�}��I�V�ud<<<D�Iݹ�+j�?'GG��~�f��C
ss%�PT����Q�S`���/_<}���Rvv����]�
E�N#������w�1 ��]�W^�?&O�,�[���y�̀�J���0w�:,pu�^�yb����-V���k�VV�>~�(jΉ��B$D�U�U�b�������AY��!;#����#±�(��_L™��o�B60i�սB�/Υ�:���(�9�L�ߝ�@mC|l,��cĖH{C8��*|~v�NDR�&�<>&�X�(> )����R_��Я��4�ƙ��l�����L,����"*�O�k�F������%'�e<]P�T�3Dk@��#GR�FM,Xk$�#Nd�4�[[[�ܼ6&&���]���N5dQ*!ԑ�E�n����DG!?��q��i�D4Ce�c���
�����n��������a����;wX�WmF}Ƒ���<x𠽽��Q#���y���رc�ƨ�G��/W�GD|��8�o>�@)�E���R<i��msu��Ĉ�p�������ߨyB��E*�r6��ߩƀB
��c�^���d����\����ܴ�e��$��+V��	Yei��{َ(��~j��Vl8a����#~�#�2000;'����.6DdnS[[�O0��f�"p8�i�[��~Ij�;uZ�j3�8/�ai@�[!������ÇC14B�n޸.�N�eժU��~R'�_�a�܆�A��G�ǁDF�s�#H�|Nw�ѣFircȐ!�I�w����cd�N��x�"��&O/�R
MH2Տ���~��	S
a�it��5))��LF�+�;�}Q��a����SR|��d]�(B�;j�Ν={�p������n�#m��!Շ��
A�-�_�a%����D)�
J��KD��u�Ή�.���	��OL��TTV�������E���HOK3VD�A�c��
�5u�s^E�`�(x�(z�W-A��޹Ì�p�|߾})�E�O��~~t2��.N�2 e�xcO�����e�^��y2g�,�����~5x�%:~R�"�n__6�e?�����E�@^�c��7���?��;v���Z/\|�ҽ�++���Z��֑�!�^���X���ᔟ={
K����iܕ���к���+�/�ر����n���-�{�Q�JKC}jRҐ���	����V8�e�p���!��es�K����DGs:W�j���u�^���b�u���I�.$�MD�cEPD�l���w�4��t�
g���c2TNCXZX(j�Lk2�3�R����2�.g�ĉ��A��(�Ab6.��-

B�A�ā��4i��a$@2dz��4��q���g898P�CfD;��PN��Ќ-)�`�����1/]�'����V���^�1JL��Sab��/X�iWH����j�:t��
�����)�T�p�Β�j3�5�7o�M�mu�������EG��A���[6n�EK=px�0���L9��9�ӧN��ޣ ���ӜP\�<t�аa��A�Wi^V&�߀�Ƹvt�BB]@���H)5�����͟7�b��|��>��1P��aSN���9;1�P�Q<5[�l��N;ғ�q]�tIQa����L�6����b�r��gO
v��Aff�rvʈ3�ӧ��#fϚ�d���˖Z�Z�o��۷�G��@9Ь��ob"#���@��k׎�n뭭W[X`���Κ9cĈ�Z������G������,��E!;eʔ�׮�[l�޸q#��O���LIaOAN��ٵ�W�^XH��}��*�9�MU�^��D&�H=5�+.��_�\^ff&��3:��3f}+��VƉ���tqv"��]��i�y�('*$$��o6t���y��A�o���n�.]�]Я��U�n�[��|��k��gOxh0&�)ab����t\���$��K_��.\@�������~\�z�(p�6ptt�߯�T4��a
b�S^����m���E�!.��('ĄR[��C���c}��v�
~Լ_:v�����8�v[༠���shh(��Q�M�����#ݻw�gնm[��ĢϏ��L��0��c���l�y�t������t�ʘ�D��ݻݷ�ڮ_7}�4������I{�A�o��Jܛ����c�RV��߹sgz��pvr`�	�`Ғ�;w숻(p�NC�meX>��EL��_q9'�]k���=�F��m��)��֯��?��͛��ׯ�$:Z�oݜ={6��W/�P���QQQ�:5�_��/"���63�Mv/���
"({�"#�B�|=w����d�t����̞5y��I�Ϟ9c��K-Zmi�����3"&"B��@�m0B�{y�\ke5��iS&8@3Ԇ��Ȉ�$�YX0%�yD�qqI�pL���?�ZVV
=U���*K����`�@��ffl«��<�JJJ���)�[.�Xߵ�P����xf6�V��G^�X�h�}Q%.����p�~���U<����]%d���"4�
5�z(� �=���P�N�`�ݱ}[�����k�[;6:jOdddh(��}|@������^+�9������z�j�uk�z��l1���{bk	eڴ��b�o�C�HNRP�?��}���m5V8.�	0z�����;6���-�ED
*��~��Y�WB_/ooj��!�;��Q�k�����w����
��C��x�B`$�����_�8d�J�����ă���!CXC��7���?�ܬ"�t�ƴ�O�&N�	��y�����������ݳg�n��B�yD/ף{7�	`�����Tt�2�@vnw[gmշ����*%<��_�XY[1kii)Pq���|��ϧO���Ǎ1uI�^R�������i�A������3��Zc"
"����&�WX�aC��0��<�u��)c�x��p�Z) 	Y]ݚ�b�ѣPo��@�����,�)�N�愑#�c�v�oG��75>&�<<֯]�$x 
Y��i�5�\�b��u��^���j��	q���,/{�����'��pg��C������T#EŸ{ѩS���8~K�+!>˟:y2�kH�.����4��4��z:ԞB#,�˓�V�(ߵƀm�o��q6�ч
��
F`��QԶ54���O�g� �զM�s��q�6xg�����)C���`�B;�UU��6�G/L����y�tg�"�q��7&"���g���
VL�<��n3G�^���#�>���w���eP����G��H�~�޽_>F�Eޠ�����
p
<z���B$j���A1g@�~�DJBB�d1U-�"{��%jQ���S�C.�L�w�9Z<�{%t�7o�j
E`znÇ���$<i2�I��@Ŋ�~��ڵ��G���tex9r��_~1�@۴]�)�x
�
�g�rjp�O�2jĈ���*.j�E�84T:�#Bi��#G,F�Р@�\B��Ԕ���3'�?�Ƞd���%=/^k<�8T�ǎ�@D.�!�b��/_��R�D�7OO� ?�07��ʌ�����&n��߀|&�'�;����w��D��Ǎ˸Fw�x3�P����:W�F5X�=k�#a
d�g��1�B5ٲe����۷n!�͝+Vl��A�o�˃�#?6*2��o����[ �*�Hx�f˖:��!r�
ax8����[o�^�����PZR�믿�<�"hme�$]��=;99"�U6��������˹2�l?}�tz�ׯ]{_��(�Z�`2��}���E�/_���\��|�Cq~�gX�!�Jj��|Z�@a������-�sg��;�n݄���ĵ��,A&�߾�9�YVC�=������s�v���o�Cm��wM�2�M�֪���
y��Z����=���]��p�����Mk��(�{+++��O�����R���Ç�LFD��"Es	w���I���$�J剻;R�k�MC~Q�����{�����JG����#�-`���s�-��K���^1�B�Q�����Fy�왃��&BJ޽}�-������֭�h��fH��>>��;�ܹc/��d�#�H�+�d�v�2~���Qͨ�����sYQѵ˗����3�[N����ХK��,O��B`@#J�7'O��R��'#i�'����߿?m��pp_
�GUe���G��-S�N��0~�<��D���,^,։��>�ܶm%����k�����ϝ��R�J@�$�4�:f�6j
����M>
޼��z�M"�B"��m(p��	_�u��<}z�@xx8�ƀ�'#�(*�~@@��+���_�����,��؎�k޾��᭨��r��@�#�S��p��u��9r��"�rŊJ�D��8q���Q�F��E�G-lni8��F!v��	S7ظ�2�z��1T�6���[���_��Y"exx�Us�Bיt]`Q8v�(#������z���E�]F�9�3��O��H�<�N&k���� =F�*B�>l��Q�����med�v�WRKTˠ����_@$�=~tt�>��u�n�Vd��_8s
i�,��3}Z3@k;;;����%8))I��_����8��sJNi���("˗O����
��b�#z6�ԑ��Y/�g��R5�*oOO��7�̞I�}�S9K�g'~י��*Ÿ|�������g�h��m۶�4|.˖-�r�(�ă�����J�x��Ӧ��]�<�+��Ə�x^�1�1�A0<��@*m���E<�
R���_�z����3�׵;�r�e���j�\�A{�jx�Ey���!�H�BjN�=Q�A"..δ�XY��l���Fu�w�$k�q��X4�@����R\T��*.��K2�LhƟ�-[b��FEZ�0]�����|�{z�ԩ�I������O��))ɢ/�ر�ZcA�r�Fc{�-z,
�QQ>�<'L�I6�x��g�nn�t
��HG\
�p 1�!!/?D�3�}"�|�^�xQ���x��+�&e�%"J �HKKc/~4��n
0�S(����q����Tp��l�£ ���EA�����/�dT��
��R�\"�TP���r�9��f��j�����_W(T���s�5�;@�;�W�^�������o��ѣ���.��Xn��c']��(��l��
��vѢE�A�Ϟ>��e�ݢ�A�GxX��%n �$C�\�������r32�J��1����[>x� ȉ�����bg�ia���Q�WN��P4a�=j����2�cA?�t����ѩ�-�߿8��H��H+j Uc��*-�tPenܪ�O�^��C�y���8l��!ᔏ=:p��,�A��˓�@�Ӛ���
2I}z ���b]е��ܱ���/^��A�HԠC����`8Ў32�M6
u�ݻ�)�����Ku�NK�;#%9���_�d���b"���
2��"z)!!^�铎§��s}ﮖ��GG�c�ԉ�R�FJ77ޔ߼yM�I'*��s2����6�YL��+[�v����ϗS=�;�o�>!�tD���Z�����U�V�3�ۈ�бc�f��ܴ�E���.]�
T�M���	�H�{���P�m���\�����'����	Bo�a�\7�l�hʕ+W�J�=�Ȑ�J�D��ur��7H�a�9~���.�7��h�x�|}�|�5��14h�����q���:
���MG�
>��?Z\G�����[YruC�=q�(!f�w�v��F�.�7���r@ �t��
Æ1�h��/�����ɓ�Z�!8���666Z]��X�`'R
i�x�"���c��SG��''iUP�-$0@fS9��6��eK�>}�,�����'�t����
�A�|���/�?g���
�;JmGia��^q9'�j
CZrS"�B�9|d,Z���(��������d>W��KIN�ڥ�@������LojB:�6:2Bk`c�Ҏ�͖�	ND
R���}?~��bz>:������I	
�3[�R�7o�?���
��B�����!�.q��
��f�4�F^����|	�����G-~�޶�U	��l�����X�]˦K݋�iIMJ2`�Vu"""�B��/���R5��a_E%��y��ݻ����z
8W5��7o���*�
��/�?���Ξ9c��1�;�_k*?����`,!�~��N�8���O�0���sj�)�l�������Ή�BC�;v�f/)�w��:��s�{B�M����N�P�#���K1�wG	�������>�q�$���k�,
�,X*�)��s>��Р1�g�(3�+��Qaa��Ykm�/i&Y�hp;8;7TEej�o��ޟ>~��4�	T|@���A�X>~ة]��q	޿3[����6[in���S���3��;�uJ��e���"/����z?��C잘Gkş��H�x��<a
��X�~w�В���)!��%�-ss��(��~k�=���Z�Zic��7�ō$���� ����nm��•�~�)F�XgyGh6�����#"#yS�����ON����NKL,.�G�'{��L	jjs���_?^�v������a3:��kW��3 ƞi2�6l؍����Ԣ�(,(����������맏�**R�&h���{�oрQ<xȦ��rl+���9s�=�i�S�
�Euy���ly�3��C(����H���r�G��i�g�Q�������D���Q��A��Ž�.\�.M�2E\�Z����ܩd��y�Q�؇�,<(([�+뒱��+W�R���
	��e����[�D<���#*��wwwj���z�H���o^W��h*
�����e�Y0�%d͚�4���?���ר�q���/�t.��'�
��u�jE%�r��JK��i���J��,�W�wA���/db;v�9�@���#֋8/I����+/���
� ��G�y�,��*��q�94$D�/N�J
/�sQ����}mp���z[[�V�Z	Q#�9r���
=�����/�>>XSC��i�
ܽ�7���7}�tN�b��/^<�Y�O�gO98����{󚑺��S�zWCB��(� +�	�y>���Mc�mě�z�y�f
(��`���SH��\=�^����R����ڋ���++tU5�S�HM����v���E3$4�e����n�����i�1%�AIR��*��j�M�\��M
�7�Q�")�	ۘ>����?�_����t��PdĴ4��g�қ��w���G ��o�^q垈�m�8;�B+m8Uc��1�gg�
8p	)K��ɓE�RMM��'GR.�E��uqǂw�ܩ�Z�
8�*�Խ��� **��)[�n�]Dܩ������C<��@D������1�t�wp@���/�ٰm Hϟ>)+,��S@�(��%q�Y����}}=�"`:	�#s���
zgO�s�s�Z-�a$�"�'5�%F���͛�E�E�(�	�y>���Mc�I�2���ݻE�7%G@]v���<&h�c�o\��v\<�%��\�rE+*0�
5/�d
F��@����o���*(,`A��`�sY)�I	xĈ<�Ӹ]P�#9)��J����A
�~��������W���Xߴ�dr���������ޞ�b�6C��4��Z�2�f�^�z��X��+����T��IcXژnk�_H�?y08֤�?gKKKq���v�؁�����i�>0�� ��<F����xΣ��]jj�
�NRS�-Dܡ5�!�3�_Ey�@�<~pO^dVZ�˧�!
)N������J�Ca/�9�͋�I__FsŸ>�NJz��YYZ��'\�C��`�e��7��.Τ��hG(�"�~!�V��ii
�v?__!C�t|��i��kM�D�ϟ��_�ZKmP�+c�V)� �A�De�%KM2�Fl۶MD镚Թ�g���������5�����zF�9���%|��Q����w��Dž�PVTD3��	�ɵ{XXV�c7Q���14iA�wK}=1��?�g�l)y˄uh�^�iH]s��	���m�u�����+���6�/+KK�N�DN�G��W�MR�^Ο�ݻ���@>|8�q�3H-(0鋢����iݾ%f��[ׯ��hϧ��B�L�~
�� w�Z2�p�\9
�ΝKM=�����W�"�(�Y�΍��A���T���c׺�k)�f"gL��I�����\J$G��_�q�䌱<3r6�v�*�0}���"2���V��`�X9Z�&M�$:�u��G�����cmm������,�7'O�#"�)Ф�
O1e� O>�

ME�<�Y�$�t��ᦨ1 g��6�Œ����I�"� � -q�t^�|A��(҆@
��rN��PN"5)i��@�Ⱥ�[�2[�d������^@e	h�0g�,�.JT���t�2ʋ����Ȓ ��.�;��qx�>$Ӌ�+PS�"6+5%��ehv��Q�FQ"�͉�<�Ě�+�G��xH$����Qk�N���p��-��hu�!������0?|xO�j���L=9���T��I���kW��F��q3b��Ju��)�tR��XX���F�T�|�1
ߣ�PUV����k׈��B�a`@�>Z8ha�R�O%$�3���^z�g�NK��R�lL#��]����P^\�A��Ͳ�ч���S�;�+q�X�@�Į����:շo���ҥ���2�S{hyYYZ��Y��=ԅ�U�k�*��8
j��/^��{ѢE���>H
�C���?ɮ\�ܯ�*�����a�(-,��+߸c}_�G��}z��t�N�81==�ѣ�������7n���>}�8��܃�+I����I!�����)EN�/X�+ڷo��������T��q5e%���x�6��
�1C+++�-�l��?Ϙ1;s挜��K:�N�WϞ2xm�?Efj�6�����w��R<|p�F�4!�!/��\P?�i�+��$�,2
�����@�^���G�WޭkW����|P
-_c��!;#���q���l]�r���z�ܹ��h2�WUUžFK	�[6m�Z���_�
��@UQ��{7��(�uٴq��GWjj�>>X
�k�L�Z���s�����)m,���L����Y�������o�*���gD��<y�XR�H��=_�y�5�)�b5U�)^>}B��>ju3����Do
L��
,H2P)#9��"�R^V6�oe�=z,[���ۧ�6�X�������(48h�S�E���:uJ��mw�N��L�0!6:
�$���	F���I�"�y�4�Qi��^^^�E�Xn��i�������k�������;���߿�(�D$�b�r�.,<\D��I)\c2x0�����m(�Z��o\��b�!!Թ���������ܹߪVb楥�R�~�Z-�=DA����A�(R�7��gϊ-/.@�q���5����(�>�k�.�O)���§O��W7���\FE�|�w�ۼ�����fiJ��d�%o�;v��U�����	��ٳf1��}�[d�i��+�^�0��".Ht�|E$+��1�H���f��ߗH�E!�i�q�a�~��>�I�C��M~��dr���D
�˗.�mN?N���<��]����G-�ݻ�1�}�;n-q_ncQk9C^V�����E
�o���7or��
������xqi�Æ�溕_�������G/@�<Trv��3r�njM������x~��sq<�kA5
lb#�+������#/Y�TD��I!�������/�K�#�k��f�
r�2v�X����}[L�Qf������F��J0���sЀg�F�~�P7�_��͜1c��kJbbUi���{���aOt�]�ahz���O�A�+A��N�VV6p�l@���S�S���kפ�)D���0��FՏFD��1���ժ8-d��1`/�|9���qDdf�z 6��1d�,�@�у4�
�,-���׃��p��m��A���AI烛!-)��[�޽_�'[&&�^8�����$���+�K����S0U��?�Y3f���C놭^����@D�Ch~~Y�
	�6m>�!�����Ã�oX�J���u2����`q�ô��#xpq�{�@���0�L���6������mc�E����ߪkRʖqG�6�w*�W]]m\�У߻}�xRo�a�eS��MHc��nnn.5o��Mr,/3���,�x���i�dVȃ��͗/�'���{D����#BBW���i^C�+�5��߿^��YRQ��?��#5:ƅ��X���s-®�Յnw�m�l��;w�<KJh�jAc�W]���,��E\�����>@��3�J�gZcV�DC�'[�o-%���@�9�ٳ�n	<��<��Uf����1��9}��<���
G��7�Ѐ�􁁁��D���ݸ�6.:��@��&�1 >������{��	�~�M�C�����ϟ=��
��Ν�֭-F�۵۲e3�t	ք�����@NE�E�W�_ň(fywof�r��u$� �}�s�@��Q?z��A�g������"�~�~(�kr�V��A�9�<z�aNx�]�Xl��
Y�loB���5	b3R��.���g�e��2�&��D��5���O	��&iC�VVM��	9�?�F��Pq;w�S;f̜9s4���?��0��O�޶r��EP�Q	� '�飇�����P��Y��GW�VBJ^ZjCRe�~��'��=h÷�_c�����C]�JXJ�͝ӔW�OJL���I�W����4�����5{սz���ԦMC~���
�2���`\�xt3�2�nP�$m��8��ig
R�[��������,|a�Js�ʫ����
z�47���.>J-�n� /�|%�M�c>�Bk�GA�^>�^ƕv=��Mĕ�K*�`x(�Gv��	�� �|85Y=dȐ�ǎ}��d쎤ap_�4���U�|R��K$۪��TQ�G�EyQq��o����=�؁?~����Y�-�R�l��
��7v}�n�9|AS���8P	����W/] C�)�]>N��?
��†З_w)z<t����,)�s��d�a�ԩ��"gcTdh��m[�J,�wo^�s&��B1�eK����%U���%=��7.�=K�
�����3g��֭%��]oP5A�W@튈���=uH�^�d	-:и'M��l�R�C�����'�H����B ��|B
&��Ǐ1��{�"/�?'���}�Z[��ǎ*��HIž�I�Ά��v7Nb)g�%K��Y�Qڌ=�b�
3���h������S��
\ZIq�of�����<k��-pdw�q��Fj/^H���N�C��Bd�����	x%���z/��fH|^^b3��v�О_@ߘ��*+D.1
^��,���um�^hP`��~<s�4'Rr6vݺ��m��#�Ǣ5777��
aFʑv�Luet��ύp����4˸��1�9�[%�����;��G�*������tF�s��l�G�)���o��0K�o`&ض�w�(���<y�uϐ��_�Xin��_=��$(:�e��'�ɀg%���:v��b���0���^\\�n޼Y93�5{{;��J�Ö-[���`@k���~���F-���Tq�0��R(�#$���Uwo�f9"�f�n�"�1�AAݻ7%���8��ryz���@�AE�"���b�
�)	D������� !�%b_{;;Ѯ؟p�D��
7j/#�zǎX#v�A9�=ۀ�<n�89�?֧(����0���&���Kj�����u555�J77j6
��sgҒ��<e����{%�*�Č�����_��;;����!vR�%=r�n3y���8+�SM���y���b�:4w��K�$����Rυ'%�0J�IA����r�o��^1�>��V�)59+��D;%������U85�(PSRB�"C��UQh��pq鄆���'�
�_�b��ܳ<���3)_�-�~�aƌ�/�YGɚի���s�__�^�^��b1d��7��\�^��1 ��Ԗ,Z�P��).5�^�$pVY�K���ӪU+o//��P4��e�d
��Çp(�T7�rF�kqI5JN�P�[�CY�$���l���IOػ����cB��o��Ҁ4���tIC*>{�켼\~�Off�fh��
etx3Ɛi���_����44���P��V,�Ǜ��߿�*+*�3ԅs�N���H�ދE��׮]�3�Ԟ=~İ.�T�1�G�W�^ROF��˖��'N�BDܾt���dyP��Xb):�C��X��]�<��ݛ\lbR��5�e����D��?�a�љ��`߾}��J٣b#����^���)�I��Q�^��^����D	<�&�1l�Wj�i�QI{�a~��!r�hIE�$*$8n/_<��M��JO`��{$����øZUR�����#
N����R�Լ黺�b�EEE�)��q����V>y�Xt�._uV���…��"O���u�J���ɓ�C#�27#�|��RQ�B�I�>}��\+�=̊�@l\�~c'.մ���:�Ā��չ��z	���q�v��yz������Im꯿QFB �p~��1�+���}s�j T&&&��`e�?!C�ȭX����A����M�p�4�������}b�fdd`��<<�u���1\�$�=,pzJ��H��ġ�ۓ'��ٳZw�	F�*�4@�eT�w�ow��%��wРA>>>O�<�\ѕ˗/^�=��#�b����~�2�sǎ%���m2�޸x*�b��QN��DPB��G<ց��e˖iU�*^2�o۶���^>{�P�ճTyq???D6��_bQ�p�2͐R+A�thkVAa�pjB(�*F/����s-��,Vx߿������Q���ŋ�(�,W��Èi�������,
]j��z+z{{�h�[����X�C6u�h�����e_�4�y��T�{��
s��W�FŎ�c���-�_Т	�_�+k��jK�"�\�ĦM�>�Q�����HOT
l&����)�'+SS�s�6��K/rM��٩]NNN�2Wj\�M�"�\٢�����&����-�6�܌!wP	Z�vPx�͝��������--V�Ղ���1�c)��������R"1
��%�|c~D&-�i��t~����8...\E�X�nj�!e�?`:#�U��~�w���ݻ��cj��UpO ����Bi=j�u��Y	����Aã����G�njc���q�v��oE��~��I��N;<4_�z��aIA>�.�d|�-E����޹�d��{���fQ:8<$��_DÓ�7%=�����_��&cc;�W~KS� M���h�S�'���f]@9�j�Oix��%��PG�����[GGGjb�*�ع��hy��d��3�o	̧O��#}di�a��I<����ųg�L���pk��@�k�5�l�ʇ��8����@eKRi@�7�c�0��Qr��c͞=��̎�ۄVJ:۴�dy~ޣ�����O�2��R���3���k��Q�L�7c���qb )���%��ח.^\eiٮ];���n??�#�ݹu���_�t�B�a`z��Q��z��
�V&~ƍ3�I�ҥ��i��[9ɰD�Q	z��M,��	���ﴇ)�=���E>�(Ԃ�48s�ÆϚb7K��\h��EG�`�T�O�a���\sr�=VH�%t��
)����u�©*����j�+|O��"�a]�3����t��I�u�޽z9;9�R�Sd7��۷?~��P��P.�KQ���B�ڈ���u�pG�(Yc��c�)Z��@����n���j�Z�6YRP@*
E9ٟt�C�=v�ȨQ���Ǖ'�#��͙ ��,�4��ElЭ[7ޟ��u4%��_l�[�nJq���D%�:sMe��l@L��L�7�
c��:2 ҆PG�Xz�������f__���!>�Q��B�sTT$?�s�h���Q�����%˛�1������ͅӇ���~�w�?���8t5<-��)--a9����s���HP.v��I "2R3(��w�K��B_쯩$m�f�q���K-]�XS8}��"���{ �ƍKm̑#�Y^[�5��1��h)D)�/\��ȉ�ս�q��K�l`&-/c5����]�./E���ONN�2e
eY���{�.|r��,�۵G�k033{)R:��5��:u
�@�8o
�v�5�B�C�ȑ#���F7C��3fxyz�j�!Crss�O(R|��	�&N��	��`d�I�UUU�Y�Dmv��d�P��6�jH�DG3ܠ�޾�"�apA�ge2R.��"�AM���Р@���
��TQk�?o�\��&�1̞9���dmȩo]d/�=K*�7�!+���OQ��~2^^���3�%M��wCFz:�؊�gggD;�ػ7�S`��|�}����w��7���وA��䢶�Sǎ@��3��z�!������-�ZN?}���3��߾<x�����pJ�?z(��!��ѣY�f�?\lZ�>?/�����Ґ��,�$?���3�௦��f��̛;��g���(x�+d{�ydb�}��?���ٜO�ڠ�bJB�1 P�m���'�I����>�y��X�[��T�������(�iD����0�y��jT"��mQ�=��j9x�`@�)O,�B��>d�<��a�I����^׽�-�̙3�UXZZN�:�����'h����ʑUj&�>�T���=z�h�.]��� *2�����e�#��_T�P��(��3��OÆQ΄7�n�����4���(j�����ZQzҸ��)��D��
-|p��I��.��  +8(_0���uJ������ZEe�����cK��ooo������7o�"˒����LzxX/Zt��D��pjFk���-�Φ���Ԉp�
8�������Ί�T��֭0~��!�����.�B�tЈ2<��.�����R���ߒ�D\yz�a,�j�f�����ӄ�[9f����~���Ɛ��M�ټy��a!�ݻK<)�B��",�������c'���nnn���jݸ��b*�O�>�o�d�,D0��֭ep���7o1�����#�w$�?�ƀ�՛7�ESCNN�Y)Sc��E5����;�G��'H�f@.���R�D�U�uo�&QF1Q"�Vk���5����{y?�u41�a_Ee�Ν��0n��D�C���H�\vz��k�E$�Bd��4`�龝<��a�:|+����c��r��r�Ұa�0�.]�$��˞�ZFFF��VF�j�*<<�YQz]�x���OJJ4H��1 :��oՏ>|x��}�GǏ�O�$��IA~>��s�'���#�pXk�rI�"=d�22$.>���䑄#�|yC}���GdW�<�
SH�Z~v�l?�LLc�:�/7�d]�J/S����
��G�#�
�emee�����6n 戀�<�pF�8;뇹5��
��=k�J���h�c����>IϞ93q�D�;���W���ȃBII1���(��1��I�IԸț@ ��~>�)��j��
E��nЩ
P#��|?|��z*��j���Ľ�D�̋��"!�*ø�b򤉤o�����	L��+.gG��vl�N	�Q*�ֿ~E>���|�������`Ş1�[i����������C暓��W�^E%m��ޫ�����
�l�!h� vl���M_�Z���C�m
���ƀ�I'"_Ԑ�п?6Ck�Q��a@&C!��2%4�����B�'NL@�‚
��
���� �'�<a��,@23j��3ɐI&�<�ps�Ε���=��iQa��{�${]>�=�e5U�B5�߿�Y���ƕZޣ/Z0�L[Ÿ�N���}N��X������J���qNhz0��xa����?��A
Hz\0>��.{������>}��j�崩SQ����i08�v_	��mڴ��W*9~;v�Z����Z�
.���~��͉�Ӈ�g�H�Lz��Aj����}�FH�01�hJ-�JO���ׯ_��
�z�R�._8/�&IU��Q�7���"�@c]�l)fr��)q�ÉFGZ �oo/ް�%�~�4_z/�%��"ޓf��'��y��N��]|�q}����;`��s�qFF��cnjy`(u�ѣ�ffM~�nݺ�$&����w�(�Z4��m�6;���7
9"����d�	X���)�f�F�F������/gGӳ1�Q�D�]g�z}x�&)>�/$
�ќ	 ��u~��N��YmiA������,�፱�����-��KX��m�&J`���?I����̜9�k�4�?�!��=�v�Z��O�]<`b��b�'L�y�*��c�
6(�B���M*
����;�&���GsI�@<3֊�!���{,���n��{��!�w㾨�(�e��u�`�^:^^^�Y���;�ߟ���l���(R�v�/J���n㦍�|``/c]H8H)$]�<���2p�p	��>}�c�3f\�pc1��7�0dR������F�P��D��H�����uu^�v�� ����a�_5�\'���A�YWg�m�ƍC�@zyzE�HFnf�W\Ύ��1�;T�,
ϟ?cy�6{��	y��TK�%���/\���C�v�!$[<w� ?����K\w6y�T]hh(���P����`�|9K>pm�����Ff�?|�={�Q��/M	˗/'���";vL
�tT��a���]�������&�����,9z��i�U*++����w��124�<��[D�sa�E���ގdŬF(�5���P·��X&�1DEDP_w��x���T�H�[�:'#��beӝS�����5x�y:��<i>^�3G�=�8-_�Ƹ�q�>8�lѢE�^j����WWWI���5�2y2��������€�3f0���������9"<\�2���uϟ��s�9ҕSѶm[y��1����ݽ+P��PVV��؈P��˜	��ؘ�s��=���]Nse�5(^�ب��S��i���SQ\����Ij���x;zD����S'ɣu��u6���A�^={���;X2!T44M�������X�2��0�5�����‚Ç�d��f@t�|��`�޹
����;w���	<kkk�,
߬{����wn߸v���3G��/+,�IOK���77=9�0'�����ϝC���[7_<}b*_���		����N�aF�n����G�`�t���mfP ���0�o����+eę3��y�.�?�T��p�&b�l	��_?����6dР��
9~�c��ƀ�"� C�!����Q���Ŧ#��#���tl�@�����1��
����v��	��9:*���~���ryq|�U`f���r�x��9��Z8`�k];�	�:v�߿��9%%y�Zkϝ�O6#S��"\+73}����׭9j���ï�\�62sCaJMM5��<ܼq�/���շn��Q��r�\_8k�5�K�f&�J�e����)22�9�5v�h�O��MUc�3��b���;�[�S�3'�Ӓ��S(�ĩ;��X����u�Y3f�/
>SF�ԙz~���	�<��肚���vQ�Ƨ6>����:w�̕��o��ܶ��>~�����zh<�P�(
P޼|q���+�ϝ>~���5>򳲲�"z"�)Ӈ�N��ež���D� }��Ӧ
��-W.\0���K+�!C��;sF:k,7I�����2�����Y+���Є6o�%�����i-��8�?n,ɇ�Ks�.��V�~�Ù�ư�10m��,o[~�p�e6A6��gF�4��Cʟt����pΞ�PlZ�/6.���ek�'�`�.]�䱾J�
����pxX*��޿w���������8��ƈ�A��L�$��i�Y�Ą���ȴ�SPgA��U� j��X�bli`�%�^��LQ�۴��)�a�R�(�H����We�@��~�e�h����o%�,޼zI��7/�K:M�����5����3+72��j�jy8�c$��@��(P�*:D�.ug󦍩{��q��0�9?}���{w`�aL��g��՞=~������	46:��եG�o�6��d���˗.���c�^�>ax��ݶ�Y�\��n�޽z�>�����
I����T�~�Ù��P]V9}�4j��Wܿ���g�vN|f��b%�T~�C�j�|zI�q'G�pز� Xn�sC"
�AA�/g���0�F���i@]�F�"��?��i��y9�*�Ϟ8~��
�^B����̓>��1�_����p�sz�Cvuq�
�1mڦ
|�vA�$�?YN,<$d����r3
d���yy�	�~�Ϟ>a9Ij����z� `2���6m~��T��c�|���B�H�4%�����ĸx�M��]�?��p��y�Z��)y�!�\\�z�m�
tH	���
�e$7P.�u�Vl��򥘵�D܂�ǎ����m`f߼y���P�ܿ��{�…�}�ɯ]�1��g���gg��#��C�ΝAX��W���ԩS�}�wC�]��z�H=���$a�^�byXPUz���lռys�VYn�h�P__h�d�Q&�v��X>p@�n]��a����oJ���_Ǝ*OlDQ`1�[G�OeDYn��Im���-�j��հ���﫨�m���	�pZ[[!E^,n1$%���Y�lҴ֊�z1HEGG)�8��ՓQ-
,g�4�%�2�TX.A�f#G�|��ꪽq�lZ��ܽy�˧��O�H�uq
�*�c��sԾ}���j1 �b֬�T�Glt4*�q��Ȅ����̞=�׻)"]�����.��ff�CXXX|�$f�7�"-�<�6��)�H�440@��2BA#	T:?Yx��?8)@�������7�B5��Ҳ�={,��q{r&KK���Z���f{ܼd�ו�g��dO�|�V-i�]:G�4a;�NA&7�>�~�2�TT�#�/[�/qLD�~�>��rsN�8��](
�0
JFiI1u���S\TD�^�zu�ر�'�r�eeY�^�^-�^�4a<�!�Π���H{Ca�ɓ'����.��(�{�
����y��I	H���*����|��2�GϺz��`�<?�ʒR~O�D���1�*5)	�&� �[J`-Ga@��Iϟ:A�
�*eH� gDB���c�V?1��ٳ_ 琚�,d#$��Eq�ʼn>h�دog'�hZ����\8}��G�*Z�׿O�r��5�M��ѣ����X[YdgϞ3��2�4�嗶VkVyy�
3�= A�pM��gOa��z���!�⁊�X!t���H��{ÂD�Äئ��p�	a�(}7n�M��E	F%8,��1 Xt�Js����skQ��;����<}A�^��̠���I�-M�PPz��%
�XiN�*iۄ��������c?�f
'6+���_��Z��R�~)a�:vp��W/aN�AsE�AeE�.��p+t��%<8� 'G
�<М��`o֬ށ����F�)����޿c�ע�d��<��MFA�Ϡ~�F�Ŀ�*��H���z���3!.ָz�15�[b�c�Y[���n!��+�\���.	w���C�����6���T4��֣;g(��¹!�m�dfr׮]V,73��#;��s/�=���Y����N��s���i��q11t�I�6t�e���n���INH8u��G�A�h�@en2�}p;�Q�pJ�[�`�Ӡ[�.��W��P�Ҁp���"&*���H"׃�F����s22���d�փCB�@�3�b|ƕ��W�2_��p���3��6h�n*���^	ʨ�l�4''[6&���HJ��������`�|jVl� i���X��*
��'�ȁ&M����
�?]|�ԍ�+���\�w`�~�I�#7ؐ��o��OmI�L�����Tf�>F�Ū�6��<_YZ&�� �Ɛ�����(�� ,77�M9�Q����=����JT{�a��<'D�(;ܶ�W���U�'P~L���ŋy/�S�aÆz�o����E%�]��d�^>����q(�={����;7o֔�iU�b�rsIT���8��6ƫ��X���d�k��/ZH�?�c�f�U�d���{��j�˥V$���`F'{{s�(<�E��sg��(�>L�Jzr����I�B� X���+D�_k�@_h߮��(��%��{Q,;�¹��B�
��vWW ����u	���Q��^t&�K�;z�Hb����24P�����y'6.�(
M�;�!��=�w�;1�`��F�=���觀��b`�Z�興���T	5�ʒ�;�hE	&��͍��G^
����,/Vћ��:}�7\K6�"b��}{�/��fX��dz�fSF�[�ZDҤ,-W�FEj�ӡ.���P�� [��$5zO�򹺬Dkh$@-%J���rS+�nJ���\������Ur���3k&)]cG�BMξ�X��֯�NO]oYc@'��l֭C���C��@�E�|��T��wc)dc�P�PN9��f0���XN�Z'���d,�v�)�<a��];5�3�eW���fPUc���Uc����������al@蝛7�>�0o����c��&�o�H�����]DA"��\�F[��2r�Ȉ9b�
33!��j5��E�H�LMsۺu�1&���K��^�B7�nZJ�;����`]x��I^N΄	df&#���]�N�`,�!-���O7���m��!H@�@N�h�%%�%b/�/��.��Z&��������{)��]�vU�ZL����=�['��N��sS%�&
Ł{�n�fTZ�c�'�w��P�w���-�A�#���5k�PW��ǏȤʧ�x�$u�ȑ�S��A��-//5J&�ؖMȫ8��"�>�w�?9|H,��5�TaF5p����>�>q���~y���<rDSi@��X�;N��b�n'�І7m��{��ٹ����Fg N拭_gm�)	��>���^�p!?��P�!7#�$BB�3�1III%��S���&�����|���憈z���7l(�ϯ{����/��I=%6:��B��QOP'�{�g���R�D�a/J"��Y3P�K��

�>u*��,Uc`�1`�aKx��qUY��.d��^�|Q����ח�ط�Ƹ
�qH3�Z�,Y1hР��8�Q���񣒒b�`�� n38e\]��U��C���M���1 &�s���Z���"�X�=~������uLNNп?N8��v�:uR��ȿu��	B��1�ϑ�>#�M�"{Q����'V�ϟs�0x�;י�K�X޼qː�����k���%B��Jh.
�:���4����l@g�0_�,$!,��w����-p��Rd,�׼��ӻ�z]����+�H����r��fN��t+��3f4oR��f�����X
���e�&Z2�E"���?�����w�S�Np����u�9@�t�Bɸz�v„����2��ٲ��Q{�2�GKҎ޿e�$u�n�m�]4*Ase����kgC�뜥h�Uch4�}�rἦҐP��޳Y;�z��)���RpIj��%[[�!Y:w�lQ�;w��+W�~���\�t���:8�����B�y"��8��$����y��Ľ{?~��*�8q���mȐ!'NtvvF�J�7��e���п�8@dh�XP����JMM�Ry�>�+'۴i�`�\�NK�)޻<gL�ʕ����@����@I��o�T''�3TdP_�pZ{C
q[Q��t�t��!�((0!�o߾��_�pFxCz�ɓ'Q�p�ԩ��2|�	dm�	��`8C�yc=	�c��2F��<|a���v=i�G� tD�[�x�0���|�"N�|��������cU�j	C����p�2v�z�˗�[��A��%�����RN��S�^=pWj~��� n��e˖J�d�d�sF���5j�n���[������6��
j������Z�l	��m[��=�P5��$�)�Ӈ���
�
P��b��qi�v�M��c���
&O����^"h�ׯq1�B�<2 ��9 &�8���߰d�ϟ>���ϟ7)�QQ�/]���)�����=sfѢEB�6z�H�=�ho'����q��*)-a��ի,�֑B����a�5�])jl�)u�V
(��W���lԳ'��P�� g���J�LS�ᆳ	?g�G�3j�.��۷n%'%-\��~����$2<&�H�dŊ���L۵3q�xRk�4���Э[���ԏ�:)�yxDIJ�K��ܿo�>�`����P���D��"���=l4�Ob{y2��
b�d\Ύ��Ԅ=1�;v }�
�mT���p���k�9p e�^�&V���;U�8���qݾ��~���7����g@\||<�b^�t�<~;o�\F��;���TC��ɴ���퍩1d����	%tD�}��D��w����O��7o@����:�s�̩����M�G����=�m�v���3y{ZZ��J�}�k׮�_��-agҿ�jz"�1u�d鲋�@��\fV0�c��ҵKc�����9Y�!eoB�}��U�WK�@����ܬH����,�h�uRz�o�p�…�fz��l���eN
�2υO�cjU��<&��.�H#�~Dd8)VYZ��(���Ax

���޽#O�]�	p/^��
k��p����@��zy��S�ø�"�-�ȱcF����6جo'�:��*��n��yJ�F\�̄v��ʹ��
2�P�獫���D���i��G�tDH}u̴���I�y�2����Oq;;::"��gƍC{�9���BNl\L�15�=�HU�s�,���A��a��>~�g��gO���K�J�4'�?`�W22�:�<!}�6�P�j��1ׯ_S�hN�\�ݸ�N+F�BlTjC�=�T��b���ﯞ?C��� ��Oi~�|���f}o
�.^Dfl޼Q�uP�{��A'`96����K�.4p W<� ��4KT�1�����md�a����Ⱦ�Wӗ�2�:;��C�07��? ��=���;v��s$P*��+7o�(��`��m�@H�.OO��[�f;ܵ;t�Z�a����}��a)'Y:b��ѵ.A��i�.Բ/��cx(�@��y�(����1�y@�s�N�����=d03�~ӦM�o߰�F��c �6ݿߒ��PgfΜA��cǎ\�����,-(4�ư��B	��:�Ν:���<�4�3��X�I�A=s��/5�7��(P)z=:pf��UUUU0��p���YD�`xN?.��,�p3��$gGGFA��>���jrN�G�	�X���i��E:������C�� '�۷4�k��E_���i#7�ĉ�NNݺv�b �&B I��86�Λ7�ȑ��]���q�L������fˤ�t�
��F��7o�n��Q���LK|tD�����z�B�s+-+C�2�:([��G��œ�ڵv����›C^a>>>@�P��A.��o�2�%w�ml�VbqR�hNJ�1P�w��eԬb�
O��E<7�U
R,pp��[[�hjZ*��?���㺻��L�4pl�
��C���z������^�I)�,"MX|y���1�JH`��K���/���4���,��I�׸q]�)�y�浟�_�V��ێ���s�HI���y˖S'O�!��V���(�B�����G��~y�)�r�ȑ(��x<VY�d�Bf�Q,(��˩J�L�����̔rߑ�y��I�ꜝ�$]�@��,��rEOx"�Q�{��6�o����.�{�@�drQ��#F�`;@�h	A�
F�k���5����3��&M�@�#y���=|��(,�K�.�X��u2��\Y�h��׮'��_���O�Nс����ntS
��0�E0���h�q�t�t�RO��ٳWĖeC���h`ڻ���rs��'�^�|�(�HC���X���]}jj
0��E�F4[ڄ��ѫ�.����Z��哅�7m����:���_c@쥱��{\�5��0�_~iˏԞ�c�=�qo]�F^�v��5j���yL���%���x#I-]�l��
ô��a��	�u$e�(��,-a��~�0鿎�f�j��;}u/_nٲ�Ox/q��?��me4j�0ͫsg�����ގ43g ����
QD�JT��$CTxS�w�-<�Ou::�C+/���e5a���K>��ǎ���$�����`kKq�m۶���F16������dF�#�̅ן�-W��oƯ.d�b��Yc�1�r�bR|�7��h��A\��S'�_ p��V��NA�pٺ��Ç/�>�u�fב���MR
	S�L�H
��u�q[�^��R�ƀIJY�%�Cd���#]��ǝ9��lN>�O>H�'�������?��#˵�8�Jss~�6��p_M
��i ���@6�C��}�������T[��;X�Wk��Ϟ��\����X}e�(fި�̨c����K�£��vTy���9��[H�@qN�_�8�Ǎ;v�(�+���*��ju/x��N�I��ׯ�Aڷ'3��->�{V,;N�4Q)RoYNZ	�<��i�֡�)���#�G�����./A�I V�`<0�332PFK:�%$�FFFR�iS�DP�g�LNN&?�(��\i�+��1@���
�
Q1�U�B�!}׭_/J�[�7	.HB	0X�Ȱ(��Zp3�(ͫ���*�ʒ�;f>n�X!���H��BH��w���J��M�U�N���<�
5�$n��i(TJ��:��{IGvCHH�f��I����:uR���lւ��k�R�ѿĈH��� 66��ɑ,[
�@0���tm
Q�ˬ1�?wv�����{��k�FX��V���e5�"����D��+���K>�ޚ���iaggw��]��V{�i�|��tb)�2��AL�)N��rR�D�Nݍ��r�J�hiI�Fd��Q���7���g���k6.k�^W��3�ֻt���l�\�D{g����7�X+*(�G	]�@����=1_Mh?e��&L@#p!4(h��!�A�������j\q�Ï�l�>K���E��'j2D%<4d���é�v���R�����'ם;w�F��MaR�*z+�}�Z`M�֭�����7���K����W)CMy�A�,�As�O�)R
yP`t	0�np�5մƐ������]�ji�ƍ3HS�H�ك�
KFDD���}����׮�Mn)�3����pAҤ�j�l����V`u�l�g(
�r�5�[��[�666O=��$�bESfi~A������#��^�+jph� \��v�Zz��!!2c��7!5�(U�^�|���������_q^5�������:b�dR%��‡�<C~G��w�p<��8}�V:@y"K��K�^��F)N��#��ʕ˼�?wuGq��Iعݍag޼q��K��
y/Y�����A4�G������3NkRr�Қ0~��2z���J�#���?�M����觀O|��,:{��eh_ZRb��П� 񇑼��"z�"^�;���17�<�������b�xL�:U"w���U��0�^rFJ�.�p`��(|tQ(�P�`g`l��}�������LZ�҇?r͚U��L�"����Q�ɉ�XBGR�XN�g��a�����A���l����/AAA
�V��%�I��A��S]QN�'/3�`{����b�ې��|ġipP!
�����"����y��ڹ�h/O��)L{РA�er=`�_� s.h�`�h���U�O�:�u,�ڣܰ��X��B@�+ٌ���{�I�J�rB_��bܸ��Ȁt�5�l�+E��Ş�%K^׽�bu8�;w�d�\�m��4�����lٲ;�o+�`��	��u�pm��#���n�'���={6����rά������#
}щ̝;GYvE_��;u�HbO�2Y��q�M�y�ٿ�딽	�>��s󚙙��QT�;Z�ӧO͞5��@a���QtQ�]!6&�G�f1��Ǝ!+� �^9�<��i,��A�*�{���r@��[���IY����[�\�'O�(G���[m��vRiz�5ҽ��(�:�6Zk/$T����h�SE�f"RQ�W>�)�{�
a�;GED��i�ٲy��4�mnҭV�NM�q�&E��E%���}����.�?��6پ};�ԙ���n�̬L�*���=�>���ф�BP',
$7֭�Qd 5}�4�/_��(q��ef���T�f���*
nݼѧoB��#Ú@c!W�7m�'�qvq뀈K�e�E�$~��U2��4�!��a4���m���镢����� ���,�!&Jѵ�`N$��YY��+I��$X�^x;�UV����j0G++;��	����@ʏ=tqqFPU���oƆ���'h�/��@�m��!(r��@ܖ@�쎯1 ��x�������X��,����8|ݒ�|��.!!!�0|ذ�t!!q�q�<Z�ݿ__�
�/��m.X�x^��h�#������',�⹳,EN�f��Gz�O�6��Uٱc��K
_Y	1{��1(���Aa��7x�Y��n� ��s�Ӈf)��kO� i�9s�^��������'�V��?lذ��|�j=cP,\�6L��̌`yG���3�Dl����@,�^m���1G{��+���׳Ld�� ��I"��ގ��A�8����w��66,�l���)�ɔKDA��`/�GRt�!��&��ˁ+�����&����數W�2�d}�uk�k�l׮]Nf��4$X�<-FiF��!.0J6�?N�(.�mZR�����ϟ=��f�ܹ���&{[�n��`��`OZb""`R6��5(c�i���<C�tTVT\�p�s��@�\�nk	Z�̚5(��
��gO��i4b�e�s��i
ލFd0Q~`�m�z�a�Al�*��2�(F?JZ'��<q�D�����CjbSF��ˬB�����r��Ȯs�M�����Z)1I�޹s���|ei�͘���	�r E$Ҫ�Ox*譕B���������P=:�� N,y���ˮ]���"��AS��reDR}�����Ѡ���G`�u���“���#j���e�f�%"�F�%X
^٨�(�;N5;~����f�/
�]8^Ow��iRD��'��N�J���2=�1y�䃊��H1��̨'��&��M_,��ŢD�p���-,,�=����!ȿ��X�z��QUZ�8�a�*K�V(.�9sf7�kLt��]ĥjW��
h�(=��^/��>�ǒ��ѣ)���׏e�7�e.=j$y�#Mf�H�1�?�X����Hn�����¹�E�޽��V��$���/Q}Z�>���qu����F��=;{��O�h�L�>~���a6���%%m��k0:*R�����~�9��Ӡ��7�?����	�h�'u�͞�o��ϭ�p�U��ͩ%�҅�bb>R�q����;�7eI����r��ѣG���-߽~E�D�"�x�4����"�?�^�m9`��|�`;�$2o�\S�v4(�(S��7{��@�چ
(�^V�sk%��th�08+�
�.]��u� �!����$L{{�wo��Kx���LC`�,���I�f-�M�ʚ��Zs����%J�Y���tAuCK�-'F�D�_c)n~'Gz�������1���%.�`�D.%��6�UGw�=���X�^8�Ue��bqh9�W�^M�~_q�&�9s�1�p��4O���6��'<�����\�����AY�ϟ���7�А�b�`�!��x�
ʦA]ݫ��$�`-V����}5�z��O]ƏK�} 
r��.ڊ�
6�2n��H>lڴ��|�G*R_�(B�U7y�.w%]�S�6c��Q�J����Ҵ$8�/��e�b�m��ܸ�()�xW�&z��O�4
>�����p�k��k-�����#J�1�� �M7��9���y��
��$"WPU��ޡ�;b�l��*�e�*/e/i���2o�
3���{�y?u��K�{͒Q�]�|�d�����.�o�^����׸R�}Zz�"sfdhS���D�.)��G335M�CvF��� �o�J����*��,[q����M��H���/����^]l\���j�B ��[gmňv�krSo�tS`�߈?��c�*:oժUw���q������c�JT~�1(�.������^(���f=�Fzy��J�$4T��1��T��G3�����J�f������N>1ޞ��	�K��~E]?��8�����s¸qF7�XalT$-��+����B_=J^X�/p=~��􊬬��v7J��$zγg�$����†
*ю+�,<����Z]Q�2G�
"1s�Fz����(/����E��ׇ��������r>�7�w��g���U�#���ƃB�dge���j���~��)Y�条�Y!��R�J���8E�q�#u_�Qx��!U��PVX�$�0����ȑ#x/UxǡC�x�4�i�y��� ��Ç��6T���9�~߾}4�M%��ĉ�ԜnjE�5���O��)����w��ъ��e�4���	?ȤI��,/�ˁ�pttd3��DQSB�?c���+���`r�i�:���C��'+�>�5�F�@ʌ�A-d���ٳ��.���1�TTd�gd��š�c�Sy�ر�6m\�zQx�V`T�$_*6J�߁F�1H�̔z����_�p�f��L�+I,ʷn�œ{��D���%m�I�1bĉ'��߿|�����X�y����S,�".Q2J���%��!�Q�A��Z�|�q7h��Ѥ�:$9%Ea���$C�����}���OeVZ�_��I�
����H��N0<v������T�G�
R��Vg��TQ�)+ָb���W��/�	��<�,!AAC
�=ztG���	�vAԗ ���,�̡b�7:wn\�E6-1�t��1�2�Մ�*=�`7�7��-l$Bv��[���S�$����Ά��� �q���Lk۶m``���]iL#� �}�1�_����a�{A�#�;{��1�?�I�Uj�9�nޔ4�n����g�~Zj�����ˊ��z�i:�j���<>f�ȑ#�#d9vh��q66�fM��>�8Iǝ;g�A�������;7��w����@�"�,�~ݽ{��{�&Յ�>>�_�t�M�8 +�� u�5����
�T�?wN�q¦���ٱ�܄��IW*��t�n„	�h����>�Ue2�Rc���R�"�'N��eq�d1��Z��+KJE��1Г�)����3�\j��%�`�<�eK�&��:t��$�އl���;�{��`5z���]�M�����=o:�u�t�,�.D����%S���+�DFL�t[���({�����ҍ���{����� ӓ�qQ'{��7o��<�7�\[{��zp�yB?�7Al�ɵ#]<6�}$�EG�˜�.��=}�-��N�<i��[EI�D�����Ԥ�A���ӧOۼy���`�xG�Y�֚�����[K[&���[7e���NTz�|D�E�_AX#��*yӑ�㛗/H�K�����[
Y2]�B�m��:�%r�&'��	4�K��m���j����*g/����q�:�	|��>%�	$�G���dRҟ��N"��]ұh�6CHdx8*AJ�+Gc��5���I�+)-�`�i�>"_�
H>۷�[}_����С������	q��s33蕞8r�kw��.�3�o<��	�����&c��3gȰ�,�A!�^<Ξ�Z[<pRq�.[���ƀ�hi�i
a;5�^={�Q�p��cW�v���ի6
���Z^T@���B�@
��;/o��:����~�k�J\�Z��3��Ah� ��1��z�%'&.Z�f:����!C~h��+�ǀ�Z�t�p�,)�i��m�6��������'���M�+!#&%'��ܵk�RR�����^g���,%G�fO�<f������n�E�Ǐ	�ȑ#ff�X�;PyRF�<vjM���,i��	)V\��~;�ղ������W�n��Ϟ�G59!�˧R/
��j��r��7�ڹ3�.\4�	�O�"�Q�1��4ze���-�� ��!C����P��k���A��ti�U#�ƌv����\����0����,|��Zc�7���1��\Z�~���7}���e5YV��/E�)Ff�w�
_��bn�O�"7�1�k�f����0+�ը�Hg�h�k���^6��tw3�#��Anƀ5�r'
������R�F�&�gc�=�׎�Fe�q�� N.�ߟ^�Z	D�<xPZr����ѼZ�����i�z�$l,���N��i��7o�@o�؄����{N�NG�����[�h�q�^���|���/��MO�<#����=����<�-���F8n���?Rl�	�<s�KV'�u�&��fffH��{�
)*��(���5E��!����ذшm�X�_
��8s�8̈́��T)�x���C5c��ƍ++-E6J�_������S�e.N��w��)���|Ŋ��$�K]�����r���֬�MD��5
ulII�%�W	�(��4��-^�u��}G'�]24Y8��.\O׼D޼j*��@��\IC�%͈ז��^����ɒ���O�6���6�N5���*�X���g\l��K��b��s���߿�R@�k׮��9���2,x�HnR��¬p���`��پx�t��|.&�姏���ƏϘ6�!+;KS���9zd�����E|ׁ�A�1:"\������͞5��T���Jh�
!�[�����лw/N��̫�"G��T=`@������[���Z[[�)�]�t� dq^.-�U���6���O8A)(\i�Q���Ñ#�s���qa!�@3h�������GGE��;��F�1���$B������B������`.�L�M���,@[<C���r����#G2��kצi㴿Tc�2�����J666eEER���h*Qc�V��������	(k(�E�c�9}:i�F�#�^Z���.D!��ׯqʜ���ˡCQӒA8�YYY,�?��Փ��._~�?�H��p��)||_OfT�,M_�[ܲ;��� XJJ
�x�جwo�Qc��O��l���/%�޾�;���n����۷�XKKK�}�7�s�:́�Ľ��`�!�6/7���O��z�E���w��˓^�v7W~���Y�^
�g~�t���1Pk�G�N�}�'^�b�@Έ��Ј�#Fxxx2aѝ4q"�.�;w.T`��a]��-Z:�:�b��/i����p:�<_ds

y���%==�%�����z����W/_�|�k�Ӈ�\���g�Kc��D���;$����9}���D�͐�ŀoKc�8����<Q�pG�>ur�F�ۈ��sss�r�[tO,����C��LH/0.&�k�f��W[Z��K����t��Z[EqI�n?NuD��Do��-7Pj�
>>>w���@�?������g� E„�@�/]�}�+K��eֈ������q$q���²��bGHCMy)ex�t���=t���%`(IU���sg�W�磼qjjZR>���v�z6,511#%��*.�>�����8F�ߤU�.�O�@>�{��ٗ�#ДQ����e8��&/j/**DN�Q5��Çż�������X� ��De�JQ<�M/�A�r�K

���R�5
���JT ����@�Hy�1P���<�UU�0ˋr<4�@5F9�%��!C@oX�j���ǹ ��~;a`x!�6 b�.]����ˇV^Ay���D��D�aI7��������Bf���ah�"d�ܼ~��y|�T��7#9�|��g�mۼq#jz�&<��c�qzRR^fFeI1b�/�;w��U ��;��X6��H9`s��Ѐ��H7">%YJ�������;k�Lzu�	O.��Nw��G���3`�1q�	�6-)�S�S�N�Z��a��6mZVf&W{~���gϞ���@\�X`�˖<Vӧ��ӧ�&[��l��{��MIc�V��ȰА~}��L��z�B�p�߀^V^�^���<y�$���&熈��O�7T�9ٔ��pM<z�0..vРAl�_�u�߿'������ߥ�3�lV^|�5��)�0!H@�֥���/��@��]���שּׂ֐�Fl��!<~�*���Q�X�#W�^�F���f���O� ����f|�;rd0q�̓7�$��w�S���գG�]��&">��M�8�4�^<o�6����]\ȍ�w#��y]�|i��Ո��_��b7צ(~���ץs'g'��lLOc�XSYZ3z�(���۳)��~�f]��*+ʑLhPd�h��z�ԩy���Çݒ%��߿gpD����Z.�1؅l�$����!C{��
)�ׯoDD�A�4���l�d �}��9N���ZLc��V�=��QԀDd��l�!!v�������`g��b5����M6t(L�eE�4�3RR�r���]xk�9<�y"����=�g�y�:���6m~�Zioow��i*'	�9�f��XXX0\�Æ
;�o�t�`=g[r�ܹ��6�6������á{��؋2��j��`! K�	N�eK�� �H|
œ)�H���n9|҂նm777T��C�û��xz�l��#:rHPм��_��Z���t�������=�x�	L���V��L���	��Y�4XY���?��9U�%�;}�����~x������kΞ9y�(*���d���q$�*��n��w��~����A"e����ᚼ{�&ɷ[ׯ�[2�^q���^�l�1|4�-[v��i=4�|����k�i�>�"�]�Ǐ��a����b��̀����{^�v1�q�)��0��^���տMKM]�|y�Ν�y�ҶM\t4�F2,̀����%g1Qt���k�2r23Q�����t!�`�%�	,A����ZD�bC
�{�`����S���vd_
-��d�5�"�������e���g�X����;i`���ѥ��`�	�ܒ�Ɵ0a����A[�y�C����_UQ{����+�%C/yd_uq~�#���ݻ�5XǠT�
�?�p����v��?��n�Œ}��b�ѯ_�?}
��y[�Y
"������GG�!`|���>�J��d ).�^>C�Ǖ�x)o�2�&	-��$enYPP�A�!p����a�:p‰�و�0�o�I�����L�O@P��U��V��l�…�
QK��1f�s��y\$�%��w�kHvD�l��2�]��I�vrt�f�c��5�	��0--U�#���-�Y�~�����B5��x,DŽ����}��+�k�⏏��^{V(���w
��Ƽs�fMy)�Z'+ŝ�Wy������@�I'7l8y�8���/_��:{��0�N8���KܩS�̌`'�z��۷2��{H�
 >r��M6?�m�Z)_8}�d��m��s�y��q�E��x�1I9��PS���?�`��^஝;�l�vR/i9�*(��V>����MN!�:־}53�O'�*A9����]�?"��7uM�@KEdoP`�СC����R�OIqC���𧐘�YYY�O�<	�+�od^�q��n񢅱�QZ_e��A���h�|Y�^=�1e����/7�߲�zT����Ϟ��v�1�YT��5�Cs�…e�%p�W���ۗ��*��������!��T�-[6#��Ͷls��U7�m�Ǐ#�8/P$������K|!��^��'�^ f6.�Q/��999AkN^��k�/ҫçNuy���)Fli,
�<d/_�.
�ćȕ+� �@���1����SAM����~�Ä_Z���u�ZU]%.�ݿG�Ж8�����:u2�b��� �'48P�����ܣg�L�� ����5$Cc�c�z�<�0�N�҂|���g��:.�|�s�N�3��Ibr�r�2��1Y�~��:�#��nx��!4x�!Na;;�D�Z�6��í֐3�M�>pw��*�K�J��T�ͭ*-���fK�Az�*�dHJ��"q�q� �y�q����u�0%����$1���Q>"a��NK�����׭�X�{���E$oTX�
F͛����ݪ�}I��$���ßÉ�+��o�ܻs�
���N?F�j�'P�LN�l�e,�
�ˠ��z���(�mQ�\�}}=����۶mKnʘ1�qx����衃�ڑ�F�%�ss8c<d��ɒ�yY&���F�hi�h)D���gO��i9|x"�3�ˣ���Ng���/P�C��^^R�ɗ/����v�}]F���}�v1]0d��6$�蟒l{����g�1��� k�����B��x�6l�`�}2��Aɐգ�	G�v�8u���ٳ�}��0�C�&	�@����,�#���6׭��DD����Ӽ�<�b��S}�۷����X�mZ�Ɛ��Jo�����[7E�c�E�ܧ���l�R�˜�SLȥ&�/,(*b[>Q��9��b�w�n�J�L�;L�kV�l*I@1$6*jԨ�l��eZ��Ҷ.�N��Q{�6��'Evzڃ;|P�q4��L������tx;8��^�Ym���#F0D�dgg��<RԽzdF̍�L��t�����Q6�'7f���c�|���[�ƀD/z�,�w�a@1��A���O�X��%�tb*��I�&�${�o����&'�
��I���I\�����д�àݯo_�O# �y���Pji�ԃ�����'�kM�@<�ӇP<��ǎ=z4K>(��ϭ[En&oO<��>���%��ĉ�VVkPh�\#��|}}_׽bOGҖ��;w��Ǜ������w�~I���������K�ʋK���oТ4�}�U4f;�
	c�̂"�p��>�ߏ��PS����g���Uz>&�
���#�Q"�	��W���6��M�u��VYZh�1E�Ϝ٬���9Ȧ1��;��:&{�.+%��h�F�
�N
|�&�$\��ج�&�n1d����Co���W]�` (/X���L�Y�f�׳EU���"�:&�|�&�}b�(aO2/D�pW�^�������Z����Ң4����/<�!*))I!$�4N/���K�e����@a�̬LO��|2}�4�w��
��qc���5C ����e�uա:u��u��(�zH%'%�scSW!xu/��5����E�Lt�����k����p���a	�7�p�[��=�����#G���i�+��`�|Fe&t�#*�J�(D����1�Q#F��
�
!4շ��D�1�@�sz��ٸEiHӧ��s�l,r�#Q&s�����9��I}�IG�������4$�@~^�)�"��S�����O�^��-����͝ŌZ��3{�̆�I�I"���ȞA"�>�Ic�	)�(��N
-�A�s3�8,�?6d0��p߾}�k��啒�<o�\�
kX�d	�vΚ1]s��w���z��9�N�<�v�ZM�h�1���ʩM�K`BBC�@��Qՠ��J�=�Fng'z�Y�i�T8ͪEid�^˕��0G''S�0��D(5Y�j�����$�����B��h�~5E��wqqax��С}Xk.����4?%�3!**J
�E��boo�&�����T��.�;�	8�0ɗ��=�92"�aW��,�@���P�MEo�aOT���o.����))\n����ݩi�5�ã����#��vv[��9sf�nNo�2��a_Ey�̛Ӑ\4��E������p�.l^���-�����!2	]��|�+d9�g�����Ǯ���6���q�Z�
if7�k�3�p])>F�Z[�z)a�V�C[�l!��M�6ݻ�9���u]Ya�+Bq�G@�5s�/���		Z#j�GL�޽	�&M��1��O�>���������燲ƽ�8���̌Z��*�e8QlcB4�ҡ��S��iV-Gc���UM��pG���O�R�ob��F��2���‘o�����߶"�D��o���$D��/>�V��������k�f��<&L�;��S]Ui�Pɼ{�6��5�믿���y��
�0W.�O'�d�����ɓ��ocF�>w���	��
��{���
��at�i�a�Bf0�&}T⵶���+%� �$m@��+��V�F|$JI��8��iS�Rk$��ʋ�8=�
l�r4���bRc�1m�a򋋤#�{���S�Zira�,oU�b6�$����urw���e�%/�?ck��_��凶��"k�RG�ԩS�/�}ǎ��.\���� ��'��"�@0&\+V�x��G0�c���8h�os�����O�دz�f�Nc!��{�4��ۿ�����:
�=��n	��1��ӫ>}��ԣ�@/y��B���NSj9Cq~���`�<J(q�dن��}�v�r��L�1p��eRA��������7��<`gN�D];�"aO����G\�kkk�P������4p Es�ȑ�1gF�߿|	�gY�s�+���>��?��F��UXpP:Q��BP);;��9,z��+���Ү�o�����T~x��}y��>�.�9v��ꢼ<n�
�_�|��YK�o�띑���yV`㖣1�e6%J+z��e�P�;w��~+�=��Чk����w��tL>���H	s��$����
� $%?�Ih�%�Ϝ��<�o�
�?S�^�Ԭ8%���ߚ�����nnB�uY�l���k��`�ZD={��ڥ34HF�)�@��W�_����G���'/i˱c�P�'���S�p7nT�5�n.�'5�+(=9�K��S\���v�J�1;�	����**���R���D��<Zc8ܲ@��7f���2Io1���5����/��عs�ʊ��	>PUɰ.l߶U`J憼;=��x�Ϟ9�2��
T{�2�K�Zm-��x�bX���|����`RC@�Y�`>�]��8�+t�_��D���\���l!��֬n�bJH�{M�,<˯_I��C�yt�ۅ��./j*�����&��b4�ʤ�o��� �׬��299�ǖ+�YA�!��b]X
��dѢ�X��_~iV��(��=5�a�.).2�E�Fx�?F���t���+W�N	9rd�޽,��]���7|� 8��L�j��`�i����f��!�r�F��]�-!�(�@�D7���P-�C�BM�VYj�d�(!�7o�HFp���1�����_Q\H�G���)�=���)� ��ʒR��
l�B4�ʒ&�G�XB��Y��ڳ�..J�'��y��%�F���K�ݤؾ$�N��J���|"�n4���2$3�Q�u�߻H�Cj>�%�,�2^m �2��Q�rcʠ���zGGN�c�H/�?CM���Ӧ�/�mmm���>ԿIIH�O̼�ߋ��<y2�9KьQ��[�nZG1i�DpPCc�u�*���7��tq�E$E!Z��M��dv[Ya���Sj!�����(���=���Q�K���2QɰK��R�Yƥ��12�m��o�s��
��bm��ǏȤ�,�g�����B����gO��t���sfff�v����o��g�׮]3f�tU	���	�5�U�>tH��'��\;ƸǪ[׮1D��E�<���P:)y�{��ԡ߾VJ�,~�N�Ɛ��F��y���g�l! ��-A��@�ٲe��{]:�4ew��!ݝ.�K�k�OW!e�3(�<�{�>��kW��("���N�ڡ+�^�J�D�����P��(_b�ba{(-)���d���9s�ܾ}�1��������C̗Ϟ��; �N������Ǜ>�Ё�?��1 ڔac^'��p�j�Xj:V���׭_�Lj��E����Sj!CFJ
}Ơ=`�A�4�3fEh��`MS�DQ^��{�I1������;�y��ŝ�(4>���*��ɡ�5���6���-��[:_dd$��������4H
�	��%A@�����ǗϢ0�����ܤn�f�*�P�Z��0�R�w��Fv�����Zz;w�c� �K���-Ac@�JZb�%%
����X꘍;V��D	Dʊ��P�r�СR_^2ӇE����d�'�k�e˖
$T�6E�@\���">=|��RD,}NN��B]ky��'����nJ#"�����َ!C�Lq�%*���b!��m7~�L����c��
��k�0E�(Ҽ��5�ac�Z€ZQ¹"	�Ɉ�Bzu�ƀH|��b��-Dc ��J_Iڻ��6 ��.�"���L+F�AjyC��H��1cF��D�7�̉��w��X�5�2B�{�Oq�/���1��>u
O�u���1�
��`�رl�8a)�o�^oQ�@87�ۏ�W-�+&�1�;No�["�ۤL<��^`lt4#�K�wFohiA��,��4������j�ƀ�%�B(4�j$%��ן�&N�z+���5��5F��+3"�Ξ&����zmu�t
�"C���8|蠐��시���H˲�KXN�}��Td��[��(7W`�=�N۴ic�U3]af�t""`�a40]��&�G,�i�������R��jm-�Y{��>�����GSƊn	n
z3�@i9���W�`q�ң{w�e�d�w�)T��t���VΎ߲]8Q�����ǹn���}�K��q�n��۫׷L��*~�����ի��S��p�S��?�Ν%-7S�?~����S�L�ׅ��3Ι��p��	�6lz����c�b jn��AO�8N/���{���AohVZ�z6k	���Rc8u�p90:��N�2�����&�����N��G�}!�&&�/�>��>��rw+�3J{����c�����Q�Q�fK�@~^<�Ҝ?w�.��o�b�B*"��0i�cc���ԥ1 ��^��'9��r�^ ��XB�=JKJR�*�rJ-Ac ��y����:��-))I9��{&��ݩFX4��uC)�ΌiS���bb�"��Y�s��xh_
�(����xX���}j&��?����J��8��fan��d�ʦKC��3F���I���Z�ƀ�Z]�i"֧����>�c�=��:GL��Y��L^c�*kRK��2�9�m~�wW�����_��׮4�X�p���5'`o��DR�B��B����?8m�;�Iu�lb���e�fj&(��i���,IUT��8պ��O�|>u������XNR�f&���ClTT��H���X��Y�rCk/]$��t~�@�����%@aLJ+��X��ee
��L��5���<z�t���5kdч�������aCX�ٿ�9e��d"8���/��e����T��Ӈ��%n�d�����tj�7m�M�GGN,��[7��:�hV�
D�ns���ڊ�Q�t�����E����\����za��G��*���-�@�Pv���T�R�d�.��Y�mL^c(&�CXYKt�Y�h�U	�$do_ס�-p�/Đ�Q�&%i۶
"���W+C�Z:�M<XSEZ�o^cw��jV�g�f?�-�
����2�
�M,�WIuWL�k����}|h��\�1Q��˗�o#� ����n��.��S077�N
��Q�D�c��6S2y�!?;�ކ��Tj��%��}�}s�#����0��/=b������
cE�%ik��\a�M�j��t���Fԉf��wn4U�|֔�,�2*2S>b�9��L~�s��I��™Ӥ�v�4�xg��Ck�z��
�"X��K��տŗ�.v�V�pݽ�R$��!�3~���P����wI�7􅂜&3V��yV`���%Ї�0'��ܶm�����$��w����^8O/�����I\\���D#�X�v����%�7Y���qqdb	ܭ/�E���`Jr�!o^���{u�7��2����P&y�Y��Æ
��H����juu�PZL��P���x��
oa���w�)Z%a�u���ѻ	��N�P�Z�gJ&�1��kS&Ml�/0��3<c��,�pv%��C�M&����5U%��d#ۥs'�5��i�"�Ftnݺ��B]�*+%�-T�5؋M.��lڋ�F6�4h��ixW�4�Q�PT,	&&&ʼX6�E����YM�������o���Gc���c��;�6ۿ߲�K
>=sf�"5������ٚ�ư���8����k5-h=�ݺu������j�47#�^)��	��a�d���!��\��8q����{�&�.�
pi�ڵԒ�ܾmpb5���S�L8�g�a:�%A�ʼX6�9����"�0��jW�\fԖc��۷��ef��;�4��ݾ��3���G�Mܿ�B�FTL$�LE{0U�!#5�y����'*�^�}�v���p�E���2 RT���ϳV%��Y�����`&���/z6N�0��hҵ��D�����-e����8�	��g���^�fΔy�l��:y���
��D5��55�U3�EY��
i���@����6�H�	
�ws�ĉ#G�3]�$mI		�-,Q&���M�S�N�66.�7x���˧O�ec�˧�L`�^�x��.�:����M�N�y���ڊkw9����Ly�=,Nz!�����(�G���R��V�T�&�r�c���_Z��:�Y	�=�4��1Ra���Cj�&����D5���4j��ִY�6<,��5�>�OKJ��\������ݻw�����\��K�1m���lɒ��P@�j�	��UT�ee�z{��h�p���	�ҍ�׾~�,���ֵZz��'G���'����{��IO'����u�V)���mr�*
ꑱ���J][V���#�[��������FlDi�~Ei���,ʴ���8;g��O8�ݺue	���l
�Y���58�쓚���/��Ai{l�����D�e�7y`�޼.�<$��{w�n�&VN��@3��..�:QYZ�j
A<~���}����1`D#�S���""P�D�~�XS4PTX�i����2o�\�?m۴�֮�;v��7�D�K"�����X!�@�����ҵ�'���$�n�( u��
j	-Xc��ix���IX���/=��^�T�/��ɑ^H����A�bbbP�\F�@��Gnnn@�8<b�oo:�W���(�J��6��B<s�3�?D�˸r
6��^�kp�ع����Nj)u%�*KJB�̗/�ܩ��mWc��C�J��z����	쫪���h�(Θ��egg#�����ӧ
@C����Ad�<����1�᫰U�o�>uʔ�~�I8q�)�Y�Z�H�AB%���0��޾yC-��b����P���	FGq+C�g��Z����@�Ӹ��X敲n�	�ߪR!�I��-�߳�ޝ;�3Adz ��>u��f}��B�0��USSC���Y��4��^�����(?�>G"s�Ǐ���,X�~��d�1�D�:,\���ۻ07Oj=�=}i�O�vig���#'��@m�^�^?�7JJ�֋�σ��#���enuvLHH@����B[�ء�ܻW���F�^��9�fҫC�%�&.Y�$$8��~��j%,������x���
�&^>��Ja��47�z��n/3���\0I'ѣ3�4��yH�tѢ�=�wWΑ�}��0_aF���]��O=
K�Q.(]��ܸv�����aiiY�[c+))9r�ϭV[�G�D<y`)6���O�@��OD<�4rܕ+W6[	���r23�����=�j�d�X�b��C�X�"�f�^��Z0q��@b�1d��Ŀ}󺰠`ڴi�q�(�ݥ7zْ��&���050�L���8b�p�R!u�޽{������[ׯ�1��S*�K��ҥK��ٳf�!�CiI1o�hv<P��z�F{�룇Q�C���@]�������_��
��;"��.�ǜ;{f�Ν�4��=!����3�ހp�ԴԱc��DqL�@y��0�zC������qӧO?~���Ľ�Y���%3ϟ=����_"}���@�	���/@IB�&�[Mc@*j~N���ׂ��I,36G�l#��@�nݺ�ǎAK@t޼���������o '={�X�d1�U�p�C�Qٿ��y�8%�r��,Vқ�ݼ.E�(H��7>Y�Aa�^^�6m��
M�{�ny���k|=p�^Ei�hʌ펈���ӦNm���3�q����OoO"#��T,�63[�����g�ƉOd7W�
��]�tE�x�۷�׮]��|��z!0�R<�sf�nժ�C21ۃ�׿y#����~��addD�F�9>W������Ξ=KcE��.^�8;3��tb����۷�G�ᱛ�"Pc�5j���SzJ
�D�	�4�Ɛ����)ʇ��6�'Bx�
F�����	B�={�,--�矿�?j��V����$���@�3b!�����:;ӛ��U�`��y�e�cXh�&�W¸
jʭ���Iz��6?+�^r[�n�P1=����cI�M39.�ƀ�"��{Ԓ�oooO�?�tp��i��#ѺO���a�>hk�^N>PcA��';5�w��ҕ�����'z�0ax�}|�^�3���aaT ����_;8:�Y��,�v�@�`��z�ϟG-
���)qu��uĉKdT`��X͐^�zFGFȩ4Ȫ1썋[�p!�ک��(��@ˑ#FD�{玧�ǔɓ�3C�		
�~�}*jϟk��� ��Ȉ�B
d���ag�h�w��;v�ҥKh��!	"%00������fi��Y��ϴ�v �u�{��%`����[���9�x�GR3���9v��jv�^Eޟ8r���+�������7p~4�	��ׯ_nf&7~��W|�޺��!Md�&��I�ܕ�PR�ć
�see�����|>z�`���qXv�؁�K]������sg�D�tJ��>�#gϞrо|��_���d}/��W\���-�2�̚��C��L�4� �=��,ko��1Г��`K�S�x񼪲�.�
jH�\
�Y[��飇�5�8|H�}��ӧ���c�r
/k���!qЦL��f��s�5���fӋ}D��*���{=ܮ{�j�r3j�64���Oʮ�к_`׵����%����c�.`�aC���Zƒ��NN�H+G�>>a��$TɬY3�^5P�����ͣR��o޼	�1�l�m�8�Z�����^�ٓ�I���>l�B��s�X�t޿{w��QD�8>�g������"5Y��o�vu݊N�,L�4)==�����_�x�����d)�"6�Hc�g��q�-[*K$�s�Cc�/�d\���*\(p>y���~�>�;�oO[D�N�z��>��9P��^㕋
����K�.��'�a�MjOdST{9���3?a�D�͉���/�?c�1Ŗ�M���חޣM���..�b؄O�<���C����Ds�����0���w�m.�?@b
A&
P�{��t����#�����?q��.�_T}�+zkPz�zDKXVZ����?a�Y�s
nయ�Y?l�0qY�����[z>�k/^����fp+�Dm�v�j�Pma�����RpIH��/@�ЌG����k��'��U[�-����9���1�G�agм�c��ׯ�Ka�Zc����(��Br���C,ʣ�4j�x�,V�����<�|��.O��P-qm͙3'"<���ʱ�k�&j�W�K/"AG��E�B�7�DFp����?��ұcS4"W
t{�k��=�a4@�m1�N-^ؐ��,s?__$�p����h×���e�(Tμ{��.}D"d��<.q�^�����lf������,s���G�%J�=gP[�p�������t�"���?}��k0-2,�>AHzrtpx�B�g��Q���ˡC�N�<�'������?}B&�~l������nY-]����IO������V�� A���[Q���>�����}����{��{�xf�̬Y3����b�!�1���p#¤t�K�=��qsu�ճ6k駟-\������Y�LCPCM�1�ѳf�"�p`sO��M7�
���+V(��H�
7
_���5���V�n���,a����ٯ_����2=��K�]�+��!ֆ����۷��;
j�p
�M�'�eO'O�D�����Eo���ڊF|��gcc���s�Yu����Ј4�*i��B
z4����D�5Š��Qe�.��������y�&�����A\�@�|�"δ���Ç�˗/��,s��~�z�bŊ<'�v85�E~���3��uk������@�%�f�:M#�9�苳=��92���!d!w�_��ٳg��ͱ uE��ϟK��W;L�k�:p�͚5C�,�,�
��@������֡];b�kժ%�ƣ��q�S�Q�/y;��1lq�l��iPc�$�Z�F܃�N�|���c�\}z�����-�4ꋹ9|��R�{TQ[�jY�_�xu��F��)^�+Thj�P|���$�󚖞f|ː�j�J$��쥣F�>����Ç/�lp��a�G1'���$_�|$I��vxi7��cƎ�e_p��_mV�R��O�b� �B��7o.L�Ɨ��a�ʕ+i��Q#GЇ�d�n�UPs�~�������%|
��Q��֋툋��e8sZ����jjԉ@Bn�N�7w��x�ӧO�ي�F�Dxc؁P�l��!z	��Q�X^~�6]�_�)�vG'��Ilc�L���
mD�p�ʄ��G�;<������#=��(�/Ԣ���s�@�q�\�o%\jo/���.�|�
�32ҥs���|��9T�q����m�f����Ǐ��K/\8�'����"˒�ͼ79��|�j��(��/�
�=s���3g��@�E��^0��wO�6m�1�{�F�&0�:99�#�E!#�B����;u�I��[ț�ի�CT�(d��\��׮�-ZDJ$�p��`��0<���PAй�E�ʕ˛��H�[���`q�x� �pa9�w!���Q*���1fBKKK���l��m��Uc0�<d��=�r���	�Qї�k9��'PSS��)����:�6����?AqR�|0��� ��Q��k�m��u�<��a�E/<��J��맧@9����+��޽{�0~<*���G�%E{1O���	�&CQ��6��;����S��j�;|�4������7n�I���s`JBL4٦�2�C&�@7@,�&(�i�fA�y�_�T�U$DGI!E��kР�	���1cr%�(��H����U�&Aߪ1X5/ܒ�K^�Ǐh���k1�&R&����AMJ��8?�#|�,p�h�?`
���d
6��9�?mi�|��}<�X�rV���M�u��25DoYE�-�E�Ȉ���t��PV���H���"##��2
]'++�T
0��P/�ܽ#��x ???ݰ5,e�l&O&�
�d��w#�[TVj]q#�5ЇZV��fHo��.H�S����Q��=|$BkE謌"d��Uc0y��7��1|���@�S��PI>b�&O�r
t_>�2��ٷ����A��4D����씗E���1���rR���&���|�2X&d��$1AjB�5�8\�mAWpܰ��"v��U����F~���E�_J����;v��^��rx�Jk��`2��H� l��r������
�(["dCz�� �&�j_�ƀ���'l��(�@%
�n�Ν:��X&uه��� 0ɮ�W.�
�����?u���1��ZШpA3z�MN�k����#€A���,�ǚ���f��1��e���&S�N�;#���s��u�4n9H>O&L�XQQ!�Z5F��z%����+!���V�
rGd�$1�%�)�1��ٓ��H)Hf\�P�!�s�g���R��`������<������T��Ft�z���S�N�\/ؐ����?>���LJZ�B���m:�"G_/�T�}v!NE��(X5F�Z5���5j��%wđ�E%���fJh�ԕ�
�ۣ��d�/����
:v���@��<e�L	ї��Ѳ��M���+"3+�d{
��a9 �07/W�]����@X��U�o�`�X�k�J(wq������Ge#�PUn��ZT���0�F	���vyn]�mU�JY��9�u%s��?�2��RWWW��r��Ԕ�˗�EP��(0����G6�c���Z5�M�j�]AV�����YE�f<H����œl�VA�d� �QBcp��DV�f�J厫��
j�WW�n��RwwwAIl<m��Z�a�
�t�t��g�a�rC�R�׷6=522Ҫ1Hg�UcP�
�jV��	9@�Ɛ�R�Vy�B�� �����N�1.Z��*z�&;�FF�%�l�5�j��bif�X���ƪ1(wY5�Ơ��@��Rv�w�(�1�U�l��(��e�1�6C�"Q�L}��V�A(����j22Ӫ1�x��%e�c0�7X�R�4)q���U�c���R��s��ߔ;�,����hF
V���Q,ͬ��X5� �����`�c��@#G��I���xei&��0`@�1�� p~�[��R�x�Y�!�L�� �vX5�i��^,B�[m����A�~^��J��F:�hR�;ʮ1L�:�����S�җ��BQn]\��S�G�j��bif�X���ƪ1����jV�A���ʻwț��|�p~X.�5�����y��e�����I�gY��6�T��+F�h�V�A�
u�1@�b"�_���f�����Q��YQ��\w�kE��Q�o^/!ojFr���K�9��]v���1�z��-�,��(�1|z��%u�����9��1���7�e���Uc��[�� �j_�Ɛ��4������6���7S��!�����pE8@�p���(V���Q,��i�2�A�d�l���ic��\wV�1��]y����.��y%�˕Эe,��(mc�}I�p��1�b�WB�"�+���N������A�)��Uc��[�� ���F��c�r�8��{%p$��ȋk�x�V|�$�-i�102�����k�.aKMHP��)7g���wV�D��Hw���5j�>�'w\�ˮ���xy�2D��#�2���d���/Y5��Qc�����E��(Z̪1H�b��A�eh��F��!Z�5y��!8�H���L.�ys�H<$F�K��uZy��?3%�q���(�f�écG�f�fe��ƪ1�f�Ѫ1H���W�1$�F�k��D�\���n�FG��D}��F�N��b�%�#�X��k��D�NU��Uc`�;�WB�Ϫ1|�CzR"��Tޗx�tW"�a�ĉdu�6Q�HY�����d	��n�� �v0jؚ��T�S%��8]RV�A"{�6���Uc�J5��ݛ��{����Jh���!����@��D}�_W��a%�U��5���;�?ӦNeTkXB��(iiib��aj��2j���gR\,��
���jB��ު1H���W�1�:z�\sgO�x�tWBc�ճGhpY`��WJY�񾹙d��W.����p�…�3f����ڷo������Eg��3��!��v7n�BZ�0�PF��(.Jv��)���k�L��x��`��jC�`S�c���p�4Yౢ��PJw%4�Ν:��iݺv!,]�,�x�#E�ut��xc|�_�V2s�L̹[�nx�KK�+��������/6�������������vuuՋ��߯߰����!�v���Õ+�w���)C�>r䰑�`P���B4�S�iZ5��j,ך5�R�VѰ5��7�@�2SX�)K<��y%Z�h�o���J<'��+����u	��)�Fz�䉝�ݏ?�@Oom�V�"��d,Lz��bʔ)?�H�3�����ҥ�%�r�K+.>ӼY3�[��?N�b�����jATTT�-���C��Æ
{T��1�秏D̒bc䚌!:V�A"���ě��J��o�$7]Lx��s(��6���@8f�(���P��c��n�T4gJK����GG��zVS��iS�֭���'O�L϶y��sf����z.�`�ܹs��gv6B��1c�P����;�vv�}��@��+�_�~M4�߽y���<k�̦M�Ѓº�lٲF��\�x1�+����zx���[V*k��پ~�rܸq�O�v�o�~�v�8:z{ac��a�Z��Q�E7�֮�֮T�v%�z���{��.����~��C��*���oD������N�0^^�5Ը�ݪUˌ���ϟ��F��hlD�Z��ׯ"����	����ǍV�m�ٳg
�ה^�O?��m۶���]0�߼Ynkk+�{��Ε�L�	|(�M�61��a��{w�����e���/;C�>}�r*ڋg5��'�,7;w�|�Y�Ջ牘�cm�����zp����"كw�Iz%9�R���0{��NuU������jcq��.V��������T���1�W���I�z���˫}�v��qM�^�rҤ�����Ӎ,pْ%2R�H-_������ܜ֭[�b�[�F>Eo
���j2����ה�=..��g5���СCK�\�����V�\�M}U�F�-[��49 �p�ԩ<�C��:;o1–eeҡ9����S�<4���0���ӹS'�~��kƌ�P#x#ĈT>��}��`�Ѵ���'&r�0�.���	Y��&r����o��j��OÆ-�
z��)���d�}�%W����qC�ƍs��޾~%;�	J�V�Z)�(��jc��L�^ :�����
a<0�ٳ�����깲1���._��y3Gu���a
�{&�+�z�
��m�[�:����ҥ��<�yy�3g�F�/���[���}!��P��#����TTT8��]��
<8=݄O��-[6�u� (!<,L��-..����}�Jg`ǎ�P���C['�55�..t΅ā�:qpX���O�<NMM�?�n-�f��~�ګW�]xn�,_�~�o������f|��m�!�9����g��!&L`��Ls��9x� �BE�O���)�:&Fz��"F7;9
���z���]5��&5)��Ç�6!��2�^��p�v����O�;�r3��`�LkD(G�}��	���'���7����Sƿ�s���F��ƒi#��k���999]�t���K?ocƌ&ܳ�K:A|�Κ=�޽{���8b���Z���e���H�C�����|؜=�Vll,�v��h(�tڴ�%W��[q��m�����v��!��8s�yh�

�x�=�]nW�rpp�U����`�pusC�vN���"�?98�!��;�-��g55���z�DX� �cǎ	
w}��yxHY�hH	\>�^��'S�q�Q�����ú�Ŗ���?$8�yM�BHz9,Tc���'ȏD���Ilc�Lk)�8�)}ϕ�I��=�w߾}ۋg�X��O��ї�=Y��x���crr��"�i�k���Z-�k}�f�
X$�;�"�HsժU�0Y�e$��t���F�~���|��Iqw���t��%{��}��1�.�|�>����ׯ�.7��t��Q�o}#�֌1b��Y���{����={�e�!II�&]3z�����;Ə+�k��l10[�l)�`o�>}BCC%��=z��'rx�=:o��.]���$h�[�n�r��z&PL�Ϝ�3gη��o��M�y�f�g����',��ƀiG�D0���$qwꮂ�Цm<��=<�~�E��Κ9��m�y�/��_Fr�B&�D��͙5�C��ij+ˮX��@���q�Ǐ3	�G_�o�K9��.V�����[�|w��	����/1z��:��g��?$�c��/Y#&DPkҤ	�JL٫uW��.o��f|�������]=��I��N���f�I?�I��wQ#�"�3��c�ĉ&O�I6��Ѣ"�A���%z��E������RS&M�$�
j۶mdd�CS��'�&��MOcY8��ѣ�999�mӆ��BƏG�*�����A��K�シ}���˗�9u�c}��d[�����ϫW�����jU�d)?�4��ƌ�_�ɇXb�42р��x���c����P���9H	1uŨ`�f<r�͞��L_�����U�����/E���� �8k����<����۲���x��x�	��L:�\>797`<C���m%	a���gi�Cl���g֬Y��kd�����D���޽F4�����wn�,�e,oݶ��jOϺ�/0��>)�&�2s������(A_!��e�v�z{w3h�\AvNxH�{�6��+n�,]c�V
S�ʕ+K�=6�i)d����VA�СCS�L!Ik��CZ�ɓ'x�I��6p[�9}zÆ
����oٴ�,p��jF1���z�*�؃B���MG����@�^�����i��L,���
Z¼��ͅ,�u�Ao���K�7@����XT�~=��"[�NJ[�����;��qCu�SC�q����H5d�I���Ōt���T��!��0Di��/���/�z0�+�Y��a<Ժͪ�>��۷/'��
���@j�h��:���<~��剸
�s��o#5|�͞5�Ϟ܌L��^zK�hd�X�[{��!:��ahD�.\x�ȑׯ�r�Ο�CD�	���n����d��
�

!lAA���:,�7�l�ێm&���ST~C��\%%%���Cd>f���޻w����C��Y�`fR|]���ȏ����8//�$,�A�2�J�'���LM���Ǐ�mq���x�ׯ_:tp�ԩf��ڵk0D"r�P�H��G�uZ6����
����/���B�E��t7�� Y����U�O�R‡y�Nkwo�_#0ØqGdZ�ƀ/�N;,_��,��A��7c�bb�,"ƪ�i�Kr�`��>��R�uE�����2!O �A s27'G�Q��4���ӣ�۶ocq�Μ>���m�3���i�2�Mz�����ޜ@B��`�ӧPSz��N����B�x��YBs,����S�<.��(��Z�5"b��$-)�lͩ��H{���.l޼�	)��� �rHH��-����D(��<�`C�T7J�Ы��ս[7�:략��Q��x<#�M�*+�:m�C��UL�M�5�9sf7]�;5��<���-⥗��&4����dD�1���ixY;���K���d�5�'%
=��,��/�Q�}r�ҥ���.ttD�#�~Ft��#����s_~��W�XA�+����UUO�����a�%��^*%>���ޭ��3�k�E�GòZΛ;���6��>:<���}�T#�
7��H��D!|LkL�i��9<d?Y�Ӈ���ލ��3�����
P"��/�]"ڃ�׮�lX��Cg���$�BKyC�&&�����Z����1@#\�|yLd�\��:���Jb""���<�6�kd���#P�O5�ΝC���Y�=ܸq�j9���SSU�vm�ҩ���:w�D6e&�]��H>�gϮ���8�B�Ȕ�-����:As�"��J5V�J�q;��,�=29Es�P��+iۏ�x޳�Ś����*��9k�2o���Fu�N�q]�C9۾c;�0������`Qc���7o7����/�p�iv_DLL��%���H����W��Y�������͍�5�4�@?��
�˘ؘΝ;�obd�fgeI	zt�
5F|ƥ�,\@�&���e�m!h�½�wL�+�27�DȄ�/[��ey�5�G@��.or�qIYJ������Ȧ)4V,굮.���rw%���IwV6S���TJ(do��-(��E��\��g��ehD�n�E8��	Cֻ�w�FvA�i0jM�6ٴ���
sre�%Ԯ�@�i�Ǐ�r��B�׮]���.Z�`Aaa��JEx_��x#��������N�8��B�����Co��8��nϺN�0E��]�P�Y�dX�sX�Zo�gUO�.�)U��>K������&�/�0��
�SB6�n����/S�R
��x�%�1�FjxY7m�x�����6�� �iiSll��H6:������+�M�~��7��E�%{��K���~����uwu��Ȑ��+��4z�۶:�,L�%}
6���d����q�7l||<ts���7�y�V�?A��1�|�j%��+J�ɣGp����s��}EA�\=�
u���˘/����8~\k7���A�[c�@�\!!/�&"�_9\Z)\4����ޭ+N���� 2�J!R���s�`iO�8�Vyy-���A>6 �ը�\qd��QP�Rب��z5�qp]�x�����K/e��l�_A�����k�l�)�.۾���[�h>k�,�������66�<�1G���{(R�I�/�uzD�ؑ�8��3����#d��t⚜ITd�F.>��i�	�
����vD��ϯ�9���]�� ;mꔺ(�}���]�v�%@�	�3��pss�*��#��7�P�I*:6c�C�;v�%/�?O�4�@�di}{��<�"
;
j)��+M��4*�"	��$*+��iVn�Nlƴ�D�|�u�� L/�f̐�+��v��5����R�=���$�G�;�2�~"^��1]+� '[b�8o �+�J�e�_�t�,�W���1�™S&)#YC��r۱�,�i�#f�xp��\�� ���ݽ[�nƙ����Y��)�5�)⦄�PZ&׬^���AJ�k�:c##��!u�U��`�#k ���1�Gk�`�Ϗ?���ˋ���Y9����0ҒH�1*���UAN})ܯ�3����N��)��
e@�E:�!-�)'����k��ܭ{�sk�wX�l�3H�ڻ��>�?����;IDAT��o(u�#�)߬�
�����kI�qD�|�w����!d�*�fCֈiT����,O�Y�`9N����2
�����F�}x�6!���V���-���T��=B��t����TZo|�333��މƑ���q��~� f,+�` Ip�
�~�[����R
�hj7��a�Z����/��6cG��Pi�lCdh(X���(bu*�&�����g���zxzh�`�ң��X΄���>����f���6��w��ܭ�E?W�
��|Ѧuk���,!�� &��x��gh��d��VRb�U���u�=�۷���l��$rR��L���0������n�٬k��n�.�5N����������5��t���ƀHcMIH������m�d��W�hH�`,�!m�|�@y)7 ��L�܌:���D���R��w�����@Ν;+�W���9)�hg�@‘�8�tOO�{�:�O��P4�x}j��u�F\z����A�jr|�$�-��fjB���Z],^c��ʢ5���LVR�P�Nk���d�;�tg���)�5c_��r�qs���.>QW��s#C�#���|�?�[W�
�6o_�V6D��ɓK٧���d������CJ|�gB	��#�_��&�0t80��P�Dsɼ߿{ס}{#<���I.:�ɓDsO{t�N�h]6/3KϿ�9X��p0��
��L���5~�-ȍ,s�ֵ+9H���V��\������A9&������v�G'��8����`] �)�ɒ�7'� i��NwwF�6�v�
��p��	�����P.߰aC�r���g�vU	!*��%�|B��j|zݻw#��b�/��H��1�GG���H����p�ƯS�t�t�x�:*����U��Dc9|�G�)�z�L�!��ḍ�0FR�]8q�0����\e쫷ٺuk�$_�����q�y�Sę��FF|��N(�]�vi��۷�9"�l����B�����~7�d�D��E;�Fhg�ͤM�6Dc��,-:<\#Ͽ�i4�!-���-<���)�i�v��#�oii�v.A3r%���N
߿��{��(ژ��	�G�'"��e�C�����tK�'��.-�۲W�^"X��̴������)�����O�ň��艹����F�xxzb��Q#�
���F�C�4�T�oB]�6.*J�S��.
Ac���$r�ˢAj@,��%�N�i0P�Z��<�V^(6�Ǩ���p��ɂƭ�{��Md�$G4D���&�o�]j�%�}Sz�2m�9v蠸���ǎꖅ4�HVաs���4���!H5�8!!�K�L�DV�����`�"�lXRJ
��di@���/b
Ac��ko0�I�)��j)��������kM��ٵk'Y��Ԅxv"J��f�i�&�9XDN�3�����A�8���나\��
�����HAH�ee��Sm&�_�09�S�:m��j�י3g���֖��u�v���	p�E��4�D<���@4����大����I�[S�9�&k����;��] n�I�M��Ś����H/n�"`�޾zIW��"(R��Y�\�ā���ե�)=hjj*;`��ˬ31��R�YVj2��os���Ek���3$B۝��U�\�LiIS�~zrm$>��k�N�ӈ�>���1`�����ihe{ƎC�����~�j�%�1�-.N��!�,�^���r�Kxx���T=~B����U���V�v34`�<<\��;w.���&�q��AƎz��y��F���j24��ɺ&Lϛ\'R�i���8�^�j\wZ��s����(7#��NZ(�#�U4�!�zf88��$n�ֺ��9N��FOy�f�DO`���d-�/]ʦ��&+oGn�"�§^VRB?l1��/� �>}�`o�r\G΍e;v�М�3���~��į\GYN7�M�?�z�a焱iI��0�����k��Y��@�r��.=�ւ]���P4�t�f�v:���1�aˁ��A���
DcHO�K���@�
Ԏ��5�?_r?�jUW]7�v��3��9?�w�l�ojb��88�`i��`Q�x
���c��w;��C߮�ծ];��
�1i�D�b�&N��������S��7n�X�];�7o&�<�oȉ����?�X� /�[V_ę�l��6k͟�긾���mz��*³3ܸq���ѳ9 {}�� c*�u�3^�������8{l86�܌�lWX}rr�<�� (

��c�<�@�Q,Zc��\:o^�$kD������ђc��s�D����Ϫ�R�173�H��ѣG��;7�i�P���\�Լys����usu�A[ܗC7HXH�J��Qr):&�ï^�Hk`Μ��5�^�����fd�s|w���ͩ��ѽVV�/Jk-�̙�ˁ�K�
�pw7�.�5:�1D�G��q�
��k 6�z�Z���ئ_7�K�Bg횺��͛�����K�}>Ç��@�0�WR\�򃻷�I)���}��+R�@��ԤDrw��y��qԡ�ф�!2"�iӦ��D��e8fϚ��)�@">.6�u�	�k���:k֠؛,#�$�i�F��鷯_�\�dBL4��J���+&��h$����#�=�A-Zc������J6t�a�'E�/;q��m"A��	��.4�g=�Σ������^��7;���2�ȳakk+�ui"C��K�{�>D���C����Cɝ�Y��+���?����B�qrr�ҥs�7n�1<"\��	�R�Ν����pww�*(�����K!Ņw����#���R�̼�G<X?��&��΢]&�LK��|C��ϋ7wI�a��}���߬�4B��~��2�iӧ���P�*�f��&l,t�cr||��ƍM��ԍ7��z�eҏ��(��?Dc�YVJ��N��eE�ׯV��'�ƀ)!����y�{�&7UX@��)�tk���,�FY�Q�d��>k��U�38>}�������Ў���rM�8�:\�x��2h���G�Ȳ� r��iS���i��F"���+��bccx�ݥs'�Gd�{�TG���ĀD��9�t�P���x%�}:���P�k"���%‡zT�׆�����"ץ�>�Ν:q� �Ϫ��o��Gb�//(ܐ�p�÷��ys(�����t~6r�_�T�;[��3+���Gdd$:价o�lތ[I�����{yy	ZTB|\�&M0(�S��3�����:��&�K�.�]����ڵk�Y�����z5���0<&�
�t<X�c�
�*��O�<k�or\]=U��(Ѡ�+���ޛӦiMt��XѴŲk��
@c@����b0ÏND�(�j�k���˙�u�z��s�?:���->y�֊��3|�P���x����B߈-gK��AT8��3g~��6���q�ǫ�]��Ex0m�~���E��  �yM���.c9��?��V u���mZ�2D$##C����ҥK�uy�t'_��t{g�KU -��%T�E�33z�Hw];�������Y���k�+@�脷���#t��e.(�B_h��׮!}�x#^�)66�O�J���3�����Ҁd�
��V=y,�fu��
6�R��ܾ]!�&y�f9�Q�Z�l� ��~�ٴ��;T�/%���W�"	)ݻw���v�1�O�<޺u+�/�f(��Y3�H P	��
Rc�w�.��_���݂o�[W�.r��2:�5+5�B�d�
�+��1�-��W�E #��[�ȝ�����vό��}�0��t���]�L@r�3ժ�Ov�+r��k3g�8ww���Q�Ҁ���b�<�8����3~��>��͝�Kdl��{��SNc��j��qE�5�D�����HZ�l9c��,݌��G����W�����m��q�g�z�y�!��Ό݁�A/g��	tx��j0?Zc�� �ec�bDF$o�ԩ
F��̟7����s��k���j�G0
Y��*I�g�˱���E��"�|a#���C��O�<F6��^<�!���i!�9&٪F�?..N�i���ׯ^8P���2�!���X{̘ѣN�8β��6+W��x�bbc�1#�F,�]_N�rk$�|���Ι=�Ȉ;�o�v�t��fo������Ő7P��>D������ʖkih86�cm]����V-Z��b�-��\�r�.YB��-\���+n>��3S�b�Ϝ8��<�\�<Sr�,��np�
+`�$���


�r���rWLzr�;b�9a��������ݺ�4��ի%��~:ڵk�c�V:�l��\�je�Ƶ�V�j���0b|���qC�&��7k�?N�8�C�2"`/��2e����׷oh�|m�U4��H��}+�;e<�$'::�ȳ�j�r���&�eK����FFY����X`�QM�Pm����ۄ,�>u�jG]�@�Aع�]op�???� ������;�C�(<V�/Hy�Z�
Fo#���I���}�2���pSz��:�Ґ����������{w�ƀ'�S�NU���~Z�l�29�Ag��)���<���
�׿{k�	��"-U+H�EL2{��C�P��O�׷.Di��+�@���H��\]7n���G�I@�{��Ÿp�h�۳�7)6֪1h��l����C�)��D�@׉�0qB-B��hxGCCCa�7�j8��
�V�=s\��F�����n߾�P����Ҽ���Q��z���͛���3�ݲ�W�*��.'��>ـ0777Ί�����იǒ񑀒������mX�gZ`Z�	���>�{?�W����˗/C
�_�;�o�,�ar�w�ܞ5˘�@��
B{^�M�a'�;�_�4K�KV��.n�S�N!o`y��W��PzR�UcЖ�e���K�!���~K|~y���3�h~-�Yi�B[.���NNJ��޸a=}���#�/��!��!��zϲe�._�D&P���)S�>�����2T(���Y��8�Ȇ�S'E!��ŵ�ku���,ҷ����K �W\�F�~�>m*�5��a2�	�_�O�Yڞ>y�s�ά�̗/_H_M!:*
�"h�|%�gN`r�߶M���A+�w�
Q�����屓l��녮Z��#�⛝f�
-����eK�jA@7ot�s�-�u���V�"�By��~���`]��h�tan���u��6  @�
�ܒ�-_����W����o(A��=㫀���ӑT7��	�Q��[��8�ظ8�!&&F"���G�*=x���d\�N���_~����_�JOOG1�wo�0�YD3�o��+�좋0a��qX�.М܀Q�R�˭���o��Jk�cG��p
v�٣;���l�ƇnhN�zh�h#�/�)��.$����G��{wT|e���-��uk�bk��ŧ�݆x����̕ꍜ|5":�{������T��vmEa� �l�5��g���9
>�n|v���K�z���ڶx(�s0�Yt3�l�9B�'�M�6�q&\�m��;�Q���0h�@���4�;�,/���|%Рi	�v3��"��7���
��\
��_٤_���˝�#��5"4��99ٚ2H�iܶu���Mݻ�ǫ.����{��I�A�/$��f���}�d���7���~��קg�i������6c���,(��q�
��:�^�ӊ8���+~��طЍ�!G�����@-�<^���.���H10�c���5�7���M門aHOO�={6�ƚ0~Y{DHHϞ=��o��LV�h$�Ơ� l	](�	m3��A�H?������6r��%���B.�\\�2y"����.���?�cggW��q\$���5�tڴn-�R~��9]����Ha!���CE�-��v���LH���={�t����Ch���E�Zt�ݚ�J�A�B�	+�-t߹�Q��|�!��߾�ٳ�.�8`>���n����U+Y�G�l��
1����r2,��u�̮�VE��YV5Qs +i���4m��'N�P�!�����Xy�°��`O��`O|�q9�����O���7n�����b�es�i`8���J�z�_�
qqwn�k*�ƳUkI�Φ�ܪ������b��C�.`�U�����
-H��Q�}�V()7ԷG����̒�{�,((�5s&R[��������󡋊u��֩�}�lttluGR���/Yِ5���r���'��4�Aָ�a�����?6&��*�ވ�3��";P��[���֭[��.w��y�OC"����J��_=���NC�s2p����+��*���h(��C�.�%����E%�������[�G�bA��"�l�=9�p�̜�l�<��R!�ne�T�$̙=����Aܮ�C����?԰aC7;9����%���E
q�du���o�Jh�+Q[�2#�6r6iX(�@�hY#ғI9n�_~��<�/�2���J��ܒ�O#��i}��M���Q����9mތ?D��\G�vw10t���n�\�[gAe�v&�5�G��{�nx#��q�5�*�����GXZj�I)B�U���J�~�M-r��?<���)��
Ȋ9s� ؙl('����.�9G�R�ز��������>�?[1U7E�q(�4�e(Y�0mH_qrtDQy:�/����!C��5bD](C�>��8^PԒNKK}%kn:�׮u�
!�u��9�0k����蘱����,����5��t�
H���H?_|u�H����i�F82�ۃt ��F�m���$� �_V�&Rq��ҥK�,j�#
n��O^���v�"b��F���/��@_'_�m��T\\�z����$r����D��7ʶl������T!�y���G�@��>�:XZ���mfl٬�S=ܶ��o��_�e$[4UFJ�NWW.3"K�w��l�cF�޼iS�^�~��`Y邢$���]�#�ԍ$���Q$wij��}�j�j�L�D��f�D�.�@�(��v戔]��ko�B#=�
�:x��B=q�x�(�547�
LAR�,\�K$99YFV�&�wz<��������d����F��'0�Q��1�MΈ��$Ce�p�޼�Ξ<|������P�����!ڴ�n�̉�� p
�I�Y�*).ޢ=�1�eemڸ��Hãx`���.X�.77n��уf6�'#�_zt����$�M��;'��B7����#���U#""Y�F��q���_��
-��PV���nط�_��D�ӈ�I��E����x�o�\:[��Pbt��h8t��;*�s�+�Xvʨh�w�t�c�(7��.����n�_�ߣ{wr��0Š�",h�W/�'R�r��pɪ����"��q{#=j��fᕠA�9o&�sݾ�w�Ξ5+/�RS',XcH�OX�b9lH�4h�]#�EMu�%�?���p�ʕ�\k�F�1a��!�[�Ҫ+��[��}�DB��k���wn�\�rss�44y,��O�@"��(&�L\�T���p�6�o�=x0!:ڈ���O�q����O��v�JE�
|ؽ{�J�$�*߾~Y�����%%�N�>~�`Zb�����g�m�P.�?;�D�t޺��{�6�۩��I��e/[j~h�ѣG��MX�����G�>}��js�����(
>��2�@G���
,����F8p��!�����(�H��O�0����6p�E��[����4�t���׬^M����Z@��'�����/�ə3gPH�1����b{�1cFCo�7�Q��4kٲ��5V��6)�lmm�q��5�G�f@��3F����o�6Ձd#�������SHc [����ԑC��jR{�����Ͻv�"J^�F(�9��P����F@��q��飇���ꏳЇn5��sL�
�>c��B�#F�k�㏦t����2��t��A�b6���y���LD�0�8�
G�OeI@��2�s���&M�/����˂�-;�\I��@�.L��$?��i��Ɉ١�Θ9�s�)C�"ۖ��N_
5�Ug��7m�ą��#7�#��ңAXJ|�<���'q,?���ȫ+
M0m����ȣv���*��n�嵐�J�{�7�_��D���w��
U N��D�V:wldD�@�H�];gΘ�� @_`珌-��1�߰�^��K��d�x=�2�A()x��,Y�ѣzQ��_�a\L+.�u��]�p���W��Աc�	H�:�������#Gb]�t�b�(#3njIo�I8|�Ç
=`���"X0HA��E^�tѐȖ]�F�
�Տ���#����`�b{DDBo��y��۵�ɈQ8�یN�E�\�F��Vg�+�/?z���&˙w�̧��qc�;���]�RzA{HJ�_��>$hh�b!�zFjB��#�o��?~��!�6��7�����e�VV�G�}��M)�޻w#
j�hs��{��VS]-�?�a�E�E�^�pN5\݈�@<���)�?�;n޴�l1 ��G�<i�}A�9�ZV,@c(��A��;|kL�̪?�����y5.�ׯ]����l�����vTv�"-�"A_�A��@���pH�X���Qz:����O�(�ɂ�@�B`�q^f��3�*�T|�P�^��C:�d��Q��u��غU+-0�e��l��UA�y�V9'h����a%W�.��K#��,EpX�K��ݻ�����1 ^�@HȘQ�~���!�z���ܿ��M�F�-3Ub�ܪ��G�Fi�-Z ���-t��l���:}��U͡�;֐��h8�˖j<Q�/Gq�
�1 RH�5O�T޻{�ƍs�O!(251�g��}.)6� ;�™��e���ީz�������+��r�p��Nz����l0m`�Q�K6n\�L �q-g���נ,������F��\vV�<h�r!#�R� ��==4hlТ�P���iM�6�c7b{��.���	
S>]���Pʙ3gt��~&�h��r�*���c��eݲ:B6vl�J֎P| �hy	Z�����^>�{���(�%��p�d���ק������V�Z��ۯt]��������H1���W/�,����2r������޼��j�2r)Hb@=�m}w{�ghGuМ�v�:ۧw�+W�-B��U=%�?�
�3�ׯopt$Z�~�@qN�S�R<���p@}+��d!���cNJ�@����|Ą;v���^�rY"�d��[�npQ[b�
��k׮��
�I���!���D��J�-������;�F/]l'�8tD����h�I+�S{}����#����#,` ��1���)=�QbV�"�� ]䢀Om�]�T��W���N_ģG������A2����,��eg�P�J�2��E�Q���eY���`\��f��%���&ۋn絟�d�)�hڄ��4q�jt_�
}��qvr��0����Cnff���СC9��"���-+�#�v2S�2�O="�&G�̴i�`1Y�A.�1B���`\�Q��M��mZ�
 w��Mkdn�i���\�'��Y4�a���f܋�
b�B��i��{"�@���Gn����9�+�F��+�# ��ǧ}�v�(_���ܱ#������Yh���d����Oaf���ãM�V$J���ej��+���'��"�FP��Cpɒ�W��`v�$R+�2׮�öbA�n��v�B�����ݼ�\����I�R��Y4��S��}rs�.������Fi�t\�N\4����^�={�a�ġK��p�J����§��T×�Jl�[���ge��7�Gc�LMݱmg��
l��k��������y��>�B����6�fj�͕�F�˖����
�VƎ
�����K�e.� #���4��ӧ�]�"���y���r��9Z2����sF���ذ����vjB��)�,�&�����)��{3��m&	Ϋ�/mڴY�|yJB��z��C^f���.΍]-���3ø�"�ѡ&QD��Y"��B�\��#�'�
kX����lt~�����EZ���m�DH��.f�1�\����#Omq�[��B�ǰ{��fg��	���t�o͓��"e��[5�O齛;w����w&&}	w�҅��Ė�6�dd���Ɛ���z�* *r	'S�N=XT�O���#���F.�-������-�;�t�a��t��E�C��4\?n�� ���,�j��BA�1�Y��[��٥K�u(4/�W��wڴI���#���s�[�}���e]�Ar;0�����L'�pN}�~����ܵSQ��P���N�5�"��4qbR|��54�M֭Y�ak���y��1�m���3DR�N�_L����-**RT�Ɵ,��!�ر�4C%R:"�:DRu.y9��'/	Pw
��m���j��ؖ���[7G�EX7{��̔ԉ&��Lj�Xޖ�޾N��WJT�F/rm���dRX���U��RF1�7=-�}�"Z:�^M�	�1��.?��j+�DF*�7(�1d�l��H��-_���c�-Zt�(�h��u�
�ހ�2n�hR(���"��&Ȗ�#zJ�w�b3��M�!�VzGLII�W�SC�Ѷm��3Y�`A�eE�m��zO�b��3S�f͜��F��٪�pz���lZO:Dr�Tf�\�I�rg�ݹM3���o͵��Hڗ�!�t����)7�I�p���0>W�<L�4$M���L6i���˳��
��0r{-�����A��3{��-T��7�` Y��FG����,YlOCZvM#���������߁� ;3�/5�E.��,((�P�i�N�B��׬\�f62�/��H\_\��/o�n���Z;,��s��q�z�ef���R��V>x�A�fo��>�����?���!>�Ǎ�
���d�ғSƌ;|�p������+�(�h��u,ʭS���EtpQ�1�]�m9kf�c"80@#/��K�%�U��Z�
�F���j��4t�����g���/�lm�,��==�=�/_�pX��8�Q����{Ųe��"4H��(���>�:&��||�m��6�]�L TBɨ7/_�1�0���/��g��?��+��v�Rbq4��<�r�
2k��rww���Y��7hգ�d;c#"d�"���#n/e��ڻ���nd�"���˓�γ[���3WAc�y�U=MB٣��!C�^,�A���b�&����^�Vu	p0eY ;���G��Ђ���>�=���K��	8�]��^��S'	O⣢xeNE�����Ka����~��//��Eڳ'�xjTc�!�T���P{�
�@v��5�ʟ@%R4�W�|�^��,`����B'�r�Ν;!���C�ɓY^5%�	���(�Sh���hIJ��QII�O\nNvg�������,��	�SP_F�2Y��!L���@F!��ž5l9`�&����_��ă�V��?�HI�=%xۡ]���m��J�"�fXH�,J��6g�fcc#}�墐��I�6+-M��˪�O$n������/b4֋���ҷ j�{��CA�w7sDAB]@��o��!�n.;�<z(�쑣��<q!7m|��S���q�зo_wWW��y�7o���)��QAL���m�G�7�ܹ��x��^����9�\����'�F�C����oJ�"�����5�%�u�9�V�!a
u)�z�ljtx8ҟd()9I�F���wls�33 �T�!,���sh1\6=�wSy���(���ڥK9PS 44T��<��Me3
]��:�׮���}�+Ź�lu/O��S�n�׾�������qn�N;�~�tPC\:q�-i��Y<@z8��n����TW�qZR"�!���]�9�W�,	�
�B:�9s�hQc@��6W777[")���;�nJ$�u���$}/�Цuk�=�S��^�����PMj+���g�'�;����V��`G~�ꪧ�.;�}	F��,�XaA����q��!��x���Pܽs{��)�X�踡g����O(��j�;wn��ܿwo��Lc�'�-���vC•�iu!!:�~<N����4)(=,�A�y^]Es���P
�);���Gy?�u�d�:�z�خM�œ\�J��^��Ty�Ąy�["5W%[��(��:iO>���ى�4��W�,d�O��a���YW
l�pw#!�E�����Nw����[{{{n�
߮�%�Z�OX?y�u��S�ױ��)��	/Y��6�CL�sd-��y��d�n۾���r����#�+�Yu�Xk�4�c+}��n�Pj"Bw�\�@�$�+��k��I��_lgK��]m�$��V-[�fdjKc�J��uL�Z#�ť�=:�	��I�2�Q��
�\Ԡ�&�ȱE��I�	L߻=<�(Hr�d
Q�ֵ���b#UR񟮕�,X���͙3[��>��,���-���ӏ�٠\�/��"/밊��*	�6���A\BL�!dxb�uk�~� C�Ě�O�������7�J��cܸq�Nej�¡�(�K�XI�oe�>f��a�>T��:��
nڤIjb��4���p"�P�o��ʲ�r���]TX��t��Dʷn�T�в�~�}��P�}n��ݫ'2Gh�L�&�4>s��X��52?++s�A�t�֭[�ݽcR ���9D*�C�;�
ӓy��f�Z��;aȐ�BU[��g��H�|����`��FA�ܢ�B�7���ॅ�ȍ??~<s�tϞ=�.PS��Į�Ks��uMPw�ϛ''c{
�		Y�4\i����mi(�LD�Z��Wh�E�=\�O�8#9I4���Ç4u�����ӛ��f�P�Wk�A�@:߲��Fc9�p W%4����T�WP8<��>��MLJ����R@wN�߿}ӽ���(~a3e
��5j-4a'o���}x�^�=�6������w�+n��֭�!v^��RP)5$Uf�թS(=%�h���.۷m�����;�5��CC�Mz���-�ǏLY�b�B5��<in���i��112
�������R'ͨ���2q��N[9jpcϟ7�^�D�^^�ѣO�2�f�As�I	�������{���w��
����Br!2100077G�0��=z�0��^/Ԍ5�X�
�����Гo�hgzr2tz��'''�� �I��l�p�Bv�,�r�`o`�hK���\)c��>���Tv�֖�0rx^r�6m^H{��|
�m>ZT eX�e�,͐�F�\���c���s�))(�j2�8��!���*�(-li�����9�M1
���3�ٶm������@|��E�45(��ys�޿Oʱ� �k׮du�4|�l�Yz��"��=���uU-��B�GM�N�d6���'O�FF�#�X6���[?~\:+8
C��@;�ę/\�@CCQ^ހ��ɒPQ�;�d-�D����ӧ�6�DDH�,�xuB7�__�4���ak%X�����~���������0���$�=�ux�`Ξ�^\v?�m�\�,��ߩ����9���ӻ��˗232�-�d3v6lؓǏ���)�x�6C��[�а4l��O;%g�|T��������;��6��F��0rc4�.K�c���M�d���
H�oz��1��AK �ѳG�����eUnCc����������K��ӫg��#��

d�(�p��1�����n��0���o����Y�ꄯ��N:]š5�_>W�h/�333�
�)�fnD:gm?v�Xa�b���6�صs'I?F*l���{)A'={�$��%�.B�JK7m�({��:�u]v�.�,R��ebhw�,\mڴ	L=f�(Y�*M$;=]�� �!h0`�0n��͒(<�Sǎ���!�wW�N7Ц���k�,����-�QD��EDF�J�ӱC�
�d�6���enn�8�a��H�4�f0�DFE�3M\ˣG���aS	|-^L%,X��;�-Da�;�+V�\ـ��^ڕ+WX8�Kr��K5ې��Rv�Ɠ���'�N)e"��EGkEc�IO����QM!4Vō2"�Qay+�;�ҥ�"6L�.�E�����V�8b�H��0n�2����d&�ޢ�1!$f	��cjC�.���@^�Y"�m۶1n��f���',�]g�ȑ�+*8�H���m]@���}cnj"�%2Vܜ�o��o_��]�mmd�p\�[>�����G�	�$����֊ư�~�???��e�o_����$b&���HV�ݑ#��ͥ.����M��[�h�N������
Q���??!v֬��'#�o��u�6�ث�#�wysC�����i��@�e�G����pq�:q]P�kӦM�ՏbaTW=9TP@�	���LW�K����Ν;�G��)��Ur�����X�9nO
�KDb�t�)��v��V4g�-�'�$�;�*�B|Yjb]�DQ~��A-�	�=
E�v�*�7N�V-]]\�t�,M��Uh�BϞ=��1�qd|+�>y�p�"�ݨя�|�)
��ud U�|q��]���c5>НE�NJ���<.]���-���MK,v���
�.��\��FI���@w ������)){�P���������-e�0�)�&iEcS�(����oYȖ�ԕ����	�f?�q��µkV��3�R��؟��@UCX��-n޴L��x>�$��J|ݹ}�c�.���auر���'��'a.���
�`���
6lX/�X"�3g��Uj/�GP-�գ[7^�,�]����D�2�>$��1�lЖr3��TV�56ܹY����|V��p��TU=��|��w�ކ�q���l�B3�SkBc@�#�(�����b�[���{��Nт(�C�>��h�9�g��۹q��g55(G��ѱS�Nf_����+@
�&㍡����f��f*Q��̟��о}VV������_�t��o�	��c2�|���	��~>>�~�6;gԙ̓vv��7�����	8pnrtD�$,
4���#�vs0O��`q;������ۋf`�>}h���OY�v���۱w�^��2R� ݒY��K5{),�1F
���ڲZpηo�B��o�>�H�T���ӈ?����/��Yh�]jȏW"���k ���C���4������dA�!Kc��PkD5��P��I���СYN�\mv���Z]~����M�@�	*��FE=�д�^�H8�(Ѫ'Od9���҉h.͝3��Ti)?�iBc����Y�TxٷYv��7�^#�쌢A@��)��٩cr˦�ܿ7k�l_` >��r���ġ��T��
�`��[7oʾ��f\�~���+h��ߧ�3R�R���T��ZHQ&�%~��M�	1pwu�P\ˬ����^�{w��<�^��� D�M7�pa!���jM�Obl쟟�䠩��Ё8�q?�X��N∘�WJB��[<k�T�m���ۿ�~��B)���C�EU�x�C��*-��N��!�֠2"�ׯ�_ĉƏ7xG,G�,Z��	��A!55�eJ�5��S�+�}v�d+m�л��I���l�ޒ��n����.j��

�K�.�qc�E��iQG��鞛�A�0�H��m��-������k�L�����>m�����;�^�����+7�ٳg+��2R>\�G�?+5���.�J��m3K/�m?�z��/��&��w��x����M��֖�Ld�YZr٤�s���L+
���ee"#_�Q؉p�f֟����my�\1
���!;=
��'Nl�L���,m����Y�gg|E��ѝ>2�d'b������6�x��|�J�k���3�ư�ޞ�ܺu��"B�{IO��%#���	��{�;�63�?s�qɤ>/N�<�t�R:	M����B�g����}�d	�u��٥s22>�W�N

($���K��&Q`]8w��'u��a�'�f��e���C?�0aB���v��ݞt��}�����`Dlh����bm.A��]P����M����gQ3

���)��Dց�B��f�u��ڥKfJ2}3���fY�n�G�Λ7Oz�"fL���i�����S��|E�A�U#B�ž���0)s4h��]nHU�����t��p�`پ�^�
��X2���TR"C��/����-<�5UO͒a�~�D�4�F.�>�b�YT�`|��fd�V��J8�>QA��wμ-�A$ 51��*+
�Y��0h�>T+x��yLx8Y5ཡ�����ڵKt(�9?v�Z�' K���X�D�|�����5��QQ�m�#Z�:O\O�(f�Ϲ���P�	j�����/E
X�e_�	�d��Y���P�b���u�Ǹw��iiR*�D�{O���\�n���a��24|�R��������[h�.��F�@569��-��-U�m�t��4�O����n���eѫ�/v��ó���
�,aV&wDz�M	�p�����G�S����1�v^NS�=�پ�̗���(�I�NK���)u��/Y���P��\�j���r��Y뒨���̙3�F��F����~��\�FƗ9w�<�"���,�m�(�DTPRD�G��~����s�⢢ySD
b��R:��u�љ)�K��
�U�d,���1??_���TO�w�_Ig5>ː���/��d,c7�J��(����M�6mM�û��������k�*�k�r��)H�K9���qQ�w6$���#]��﮹�/˸����� �r���L���uϤ��p�k`o@���j�Ζ|/��t�ԩ����So��8s�����S�b��ޡ};Y��,D<��ͩ1��-��U��J�� �7�Ji�7��x��a͚֭�e��Uڣ{��Æ!��M�ڌ#-�p�/_��N/7�ݮ�W}��aAL3���ܜ��b���JJ�5�,t8T`�~�M�.˨�<Y�6DD"��9������ϟ��epb#"?��;�Z`��9�,4$䑁uI�'r��;������@�>�=�7xР��\���)�����o�I����Ǐ��� �|��b;1ٗ*/��y�E�!srt4���2����6^v��߾�3&Ο�c}����������ۯ��	�u����o��B
P��U{}�����maaN �f�q�P�^yG���d#������Mnf���q'�y��,��(o^+$G6E�v�6.�t�֊��<��.]�Z�7k,W5]Δ_�F{6/�Ϻ�x�¨Q_�+�/�s�B͈H|��\�z 4�d���K۟8q�[�O�Z���v�BT�6<��0s��:��}�{��,a��v�…����Mj���~��A"�|�߳�5LZ��]A�X��`ooߤqc5�f�m۶��䪑�N�@�'%�U��>p�

U3����I��7���Xo_��̇"y�ӧ�����ܹsjʌ�ǒWc��Q��D`C�bcM1wus�2�t熴I�# �%�.t�cr\��N=� �c��H-�yѝ���n���۞c�����+����yZ�Ǐ`��!�>ʥTU����9��,IН-�^̦1�*���$T����<t�}��˘�H^�Yiղ%*@v��%�Et�h��Νe��/�-�?J�^�}/�{��~��M0#3�f2�?��;�䱣<��3-1����	�v<{���}o�����da,�es3�u��B/�?39DjZ�e1y��&%�p\h���:�7��L?r��cǎʞ!US]����t��Ҟ4y���ݗ.]����
`�/^��g��6��ѣF�2ګg�j¸��%	��EԹ�4T>�
���,|䝖��lr� ��&�t4!�ҧo��M�@(ew���uPP��O%�;9��5��@�	їKaa!�MA�NNu�����ϣ�O���d$'!�%�����SR�[à�}�6���Gx`�ؾ���#E��v/|�Z?�k#�o��?�zB?nN���_�U0�0٢�<�O������ѣ���/X���p{��p@��!�!+��qT���gLrܸq�[6�������|�2J �8qJ������4��%�qp�IZh�� "�(�t�,��H��12�%�ݴ@3�Q�}�2=~�	Ɗ}���̧L���E�@�"�e�g����z0/O:�t�ʉ�eQ��1�T~�ԉh
}�lY^F: _ُtqD&Y�:G�uhW�B����޿����q0��:C�+�cҿ<@�e<�frzz:t�O`�߾}��̰O���1f�eɀ���GcHIH��W$H�4�g:�e�6��T�����'�l�G3m_���A���Q.��R���(��
]�{B�N��4a�
J�Ҭ#7�._8�QB2���^U�BE'�n�Z���9P)�q�Z]zr�[�B]���޽��+��8�`�@C]�eElj�:zD�O׮]�e`N�8����,��[f�k]����P֔�'�/[�HU���U9(Mv� �9;�Gc�oU�B��!s��]p�vŰ��<B�/(S�܆I�C���Y"YK���EEɘ?��%,V�z䣇�K�c�ر,��ܽy���{��x�R��v���t	i�����B0�$ԡ��}���|��P]��0��06EB��<����M�#hkt�	��}��J`��}������c>n?��P��G�����MO��6mXo)[or�cF�2�ưg�n��.�?/n{��ecF���x�@��E�L��\
�t��yS�K�@^>N��@F8��Y�[7ˁ�O�q�ܹ"l��K`Z���JK�i�Ȏ�����t7~�3'�WC��.3g�0�y7��޽R֫��s�f�K����Źڷk��__0�Ԁ{�����_�e�ͧO�������Ϲ��e:���f�v����lCp` �S�9N �ƍ����6�A��\�p~Ŋ�<d�͛6�뻇��������&�~�OŗO���JON�<�*���y�B��N�CEE�"[��<z�(*��7���-K@>'JSRg��̜9�eG޽}
5WWW��9�����Ì|14�XX�؆�����!�~�w8`L-�?���־�S����.^���`Q8`�aDA�r,KF4�R�J�JO[�~7C�A�B�J<����1�Q���Yپ}���4��Q�
�Ü�w���W<|��:�q-H	�h�+��'���@���}y���4��'��SS�BH��M7J�Ջgt�:��]9W�U�iA޴0��ܑ�7���t
<Ȇ�z$.Yff��>`�d{�� 
�q�k�J�'�_�~�2���{7��0R����wh���wī�<�%̾�j9e�MB��	��K͕��)�)��=<P��p�q�߁%xN��J��ݻw�}0��7�'��j��v����b?�7��$�!tc8�ix0!3%��?��T�8��=��x�6��Œ�K�.��7>>^:MX��ܺIR'�\V��
�.{�dX��hp`?�w����#�_�����$~/n	���Hn&Y��Ԅz9�W.�W(z_D����^z����aV�\uU=)6�܄�����P	V��_�qq��b����Q(��gW�{ɬ1�xl`�Eb+���
�i�)�=T�a��CD�p�
�ȟ��,5b&��&]b^�����s�Κ�o"_3�T�X��OΝ9ūbʼnVVjr��dž��g5�V��R���@�,?|0<d?O]۱C����	 ����%���y����'h&*�M��#���Ɏ;2������*:��M~8G���PM�8�.�$͙=;:B|�J��R7X~Vvblܒ%��J�8�믿<87/Wܐ�@B���'�[�['h�?a�h3����a��ҧ��M��qQ�l��̌�
F���ޮ��/��xz�"BC��Ro�^�u[5zSP㍷�OV@o�)jϾ|.eA�}2t�PE����d�k�/�|��k�� c"����yDZ��]���$.�xw(I�������V4{��%,���tj���2��
#ݨ�����@C�'�qc�ґ�P��͛�D�X땀7�^����G�L�8�63t�Z��#��,�QYQ��#���A��-�
�G�[QK�h�B���W�ݿ''7�,O>ȧpo�/6�|�YYϝ���}y�dBs���<ysWQnn\��ㄓ܄'H�mo�����\a@��n	]#�EuUo���W�k=:��4���-��Ў�>��W]|�
���$]��}�dl�c��kW�N����`H�PIc ç%%�\���A���#�UW=%�5B������[���<q[��@??r�����#(���1�&����S�EZb�#Gy�
��;f��A�� E�Y�i�,���WL[t�:x��q�H�ސ#`<�G�x��]ǰU�H_Bq8�H�/���|�XG�n�dr%�.M�Е˵%r�j�)s#�N�]�$���^!��������\�p�Hb<�@�ܽۋF��k���=�jc)�9�^	Ck�NO
��<h޼���C<"��} �\8R���:��}�wK�&]t������m`<\X@_���7>�ٳ�z�����s��Ժ�k���(#q��p�\�r����?����Ṳˏ
�|d���٫�J~QS��v�˶m���
@�L�M[=v�7J����ea�'�~���\���'O*�w�G@n�N����r�F%��:�P�J�r�L�9b����
��>h����7@K�}Q�����..6Z�
���'��$�O�%C��#r3aB-p��~�����!������������H�c{�F��k��fΤ�tڴirQ6N��%W���äoj?�u#��С^�7�W���-�&t)��N�F�RhЖ-Z2x��y^�v�R��ar(��wmݯ���Ζq�\�x��_�<,�?H��t�,��I��\�"F纼y�]�v*;d1����W	O?y��W)�	�@SXbo��Q�<q&
&)�+W���M��N8v�(C�����S'[���NJK�	PHX��[�;h�췯^��e��	B�ssu�V���)��P���A�h�o޼Y���G!�c�R�XH��%�]�.�1A1R}�E����S`�u���CL7��%�e��"�S�F'N��`ܖ�%m
s��E���ݿ�я?
e��;o�*�-U���,NFc�d�����m�VF�,���R�1���IE6!!A�[\W`p�pX����}Ш��琚��k��3xP��`�V�猺d<��X<�W
K�#:b�0��ۧ�,dEy�J�-�91��2�S#9�=�qѿ^'%*�HY鋴Oz;|}}e!+����##��c;�!�W�ؿ/���QN6�')��ۤI��L����		/�0�y���]d���˖,���J��Җ�}��O�ڹSG��9,��2vy����c)? '
]���j^1�wn%"�=݉����#>yTI�=}T)e!�����ʒ�o\�Ҹ��%%!QѐF�_�\�#���fM�^�t������(zVXP�[5��;��M�;�\d�lPn,#�{��)Ej��=RT/��ٌ4I�?yk�1�n�>ylޔ�^J4�生�ђ6y�K�z{zЮ1�o*�l�:r��>�{u��u�`��"�п�o��.��-���M�4a�?��=�w4`Q�޺3�wE�%���8�^�c��K�
�y.�_Z��/��.��D|%���n��#F�`Yi51/���5�O�5	� c���`00Z�Y�Ya�9�D&�����d���W�$(a�c�3�O��g|4�i�Q��[<T*�K�,�k�Q�*ˍ�|�R�Rk!���B	ܷϤP*��K:d�(�����:E�'��ٳgy��$��莰�M�2E�$@��[�`�GM:,�o-~�!��zy���~��ݐ!�YČk3w�\#��O�M1y��wh�p����y�r�d�Y������[�l�U/Y��9��Ν��1:P �
]���P�e˗����-�.A:�SY�)�#ȄO�>.\�H�D7~��턽|A�j|88Ǐc׳�O�,
�Z��5
�!�mǎɓ��9�?��c�4�e��չ�P�yM����5��O&��r�����6C����p�/RRr�1)HxA۵k;���+W ���ٷ�1������~����o�-G?r����C����}�GI���I�
b��ȟ6tH�Ν8>�ȑ��YMA�22҉��O�ޗ.�A��|MTWU1>���Jiʹ�D����
�k'߿���Ј�] ‰o$|�0��m���1�%�Y�u�bbձ��24�6�c�X��S�J�o�Z2֮YM��Ϟ�cŎ���@|�8*����¯`s��&���&O�����џ0q"�GpB=�Ϛ�#nD��-���~F׭{���v�..���IE����rGW�\>~�8z�A<����1��޹=t���FfF���{#�,G[5"7�L[����ю�����̄2�璁��(�=�Y���#޽{wҤ����ɓ#���=�*��0���N^V��Ν�9|���z�Jϡ_߾���t3'O:D��đ#F���嘃?���8�<��I�_c�F�{�X�BbHr
�ݣg��[6#�\�?����A�nHT��_tC����ǎ���`ooω|�7mR�;a�J�zy�1zN�L�F�J�/M��~"�RX����=s��B�	����C[z�F�!��ee�۹����M�����E��ՋCčl��	��	�P��$�����F�ɝ�k:�
�?~���EB|VV��K���ݽ�y_PC�d��]0j�	���L��a�Z��pF������\�o�Cbڔ)�ǍE�Z�neh�ƚ3g��۬�Y�޽�+��߄����S����K�͝k�,kq2e\hq�ss��>ZT�[�D�䋠p�3�cdx����]�?�
�)ػ�kB6T�zQ�_X�Ȯd_����߹�$"���-܆�D0�իV�G�z�yY/8����c!���2w���𝊢�D��� E��RHo@���bT�w�K���Ts��^�t�F��7 ��hQ�,����U+�͘1͈Z`h��=!1A�3bP��#����3
�9������
��ߌ}����
���gN׋vLKQ�A�ܹ��䍎�"�2vAb3p�:�N\mYY)���^^�o�y[Z�W,1|�j�V�իW҇�n�BuFOLL`�{՚�,�N��y�ㇼ��Ժuk�E�fJY4���~v�r�ٳf������8X!v�Qv·��k$�ݺu2�||��1��`b?�q��O�dd)�b��/�l߶Mv��֮uh��j�--00p׮]�bl�7���?��8ί�?c�
�=�á�+7V��+�V�V�t�N�~</��z�薪1���$K�]n�D��@�Nm��
�(t� �S�h�
h�o^���{��9qT�:yR��� [|�4��G� ����t^�x��_-�o�M7VV�r�����Ȥ"Ї"#"D��d��'Od�qJ͚5���1� ��Ƞ
{*�W���J�i�k�(<����Lԯa\��!w���A���F�U��Ǥ,�8�8��L>�g*�N�k	Xۘ�pr�%���T(��׬Y�	�J��l�H��?�cG��U�mΛ��Ȁ%Y�,*��eQ^�*5HFz��5����l����#q|}���4jԈ�X���J�_���i�Jp�3���ٓǏ{|L4��4��
BR���F��2?g���%�
3o\��&č��L��C��L�ΐ� �tذ�5�4E$״i��$@�y��\zWz�v}���p��U�A.R�vv` 
��E��s���0_AϫM$��;���N6:w옟�m^U�qt��TK���:��uk�36zԗ�>�n��S��+�2R��(��Ґ����__r��%<�{����#�7u�	�8^5CгP�**nm߾���A�n��
���l|�$��,V�쌪*����V���w�~��O_�o�B{�V�Lw���u�ڕN���+B8EQQ��a��ݟ1s湳ņ��y�j�6M�8���䫞<����g�W��������vD(`{��^B�\�᪮��p%۶m�����f���Ej�&Mb�+el��@?r̼==���[��Hm�d�9��߾I���/���.f���Z�)���r��|�"q�f'8�Mv,+-�>m������q]>�����+ʪ���`c�U(�S/'�p׭[7ޔp��)����G�"�?D�!���t�s�̡
�G�>v��+��Vѣ��c�㢢�\�3'��,����6{^S�=�?��d?}|� G„���??������mp�iI��UG�<���x��r�bP;�E��a�r3��ΖW@e��[&1�.��9y�F��]�D���)--x�ػ�)�qc�رd�qs���i�>��.T)<ָ"�`_�\-߼~5bD]x2�E$D�r��̈́!p<g��f��i'#d�҅�њ���=���F�g�PA�P>���"�
��BO�ڕz�te�JT^7��Ŧ0���mfyCjb�Ҕ{�MR�(
�>G��."��~�LB,��~|LD]�8���F��� j�6>v�h�N_��'N�(�TnN��ѣh�a��yx64��׮
��_Ħ��e�ȑW�\����Ԃ����.�;9|Xu��^���$�WEnN��9?y��q��<�r���1/�]�t@л��C��;� p*�l�2�o���^5`��U�%�=P�2[�LN�����f�#=���n���b^U�qt������)}�h����	
�GNr(��<~s&E_
�<zH���b��	���I��͠�$b��NΧ��߮_�N�����I�D�Ɂ��~��r|�fgg�)�&ǚ:m������ʼn�.��͛7�[�����sEߓ�ںU�;�K�l��<��	���˃��zZ]H��� �3,e����]�_P(-���s֩MH(E]VY(� ���Olن���l�6�<�a����[R�0��Z��>x�f��1��Y��"dT�.���_q�fL/�?X�ڿ���e��8�͛�d� ��r������J�&;'�M$��0��ի̫��J�ש1`;�UW-��1T[�r�8�1ѲE�;Öyzz�B0
�n����m�|�#q��肯�۷ч4!&Z��������*D���c��'4���BV4�`u�&O6�*�8��i�4�����Q��?:DN�?��F��߱��t�M�}�b��
�������D(�̍;|�0�ݲsC�����2 �CH�iӦ*�p+B��?e�ٳG�-`$�v���@�jLL�u#T[�reŭ��ٛ=VC�_��5ٻ̟7�>�!x���}9�my��E0DIF�Q<�$����X�cb‚��:�1���mfyC�n_r�d?T�N��LCG���,���,�\G����x��z�4OP_��>�x��	��F&y�f�����|�Y�y]!biƻ�z�r˖-H�$6�7vus�}��o�P+72�W���4n��<T|��J�O�G�o	�"�پ2�>�0^�pAv|LٹG�'`�����KZs�(7CP0o�F�4#%ռ����1 E�Q����#-|�o�q,��<�O�h
�D@D!Q��Ͷc�V�'���p�lAc���l�c�9������O?!�Mv�z�t���Z
�ϭ6� ���<��СCJ�^��>��U�z�J�v�d����׷��z�M.��JE�./��jS���HBX�#�����\�J)��r�
��Q��,o�y�X��(�(׾c��!T�n�]F�kM�SRDP��8i�@{�C��\�o��=�
�w���ã##��a���?����/�6�@��g��Q-h�Ukl�t�rҲ���\�`�rC�SF��1�a�{����@cSm�遺t���K�G{�E��,
a)��7�W	�	є�D���FX�ZTF��	�l,�|���y���-Lc�8?9r����i\�l�,���d�K	��?b�C+Ň����4[\wl�A/�}QcZJ�5l	v�qd��̞=[�e��§�,�����4������XQ�N��%+���g
9��)H����'��Ҥ�4m�x����u��n////-|j��Ϧ���D�[��}:�XK�nV.0�r�r�7ۼm,LcGU4y`Th��I
DȖ-d(���)�C鎈3ie�ҥ���=�Ұ�y�����}�������ǏA��F�&dTd�Y29�p2PA��
a�ȉ�����1��(}F�?|�P{��Wu���D�t��JW��SC%��J�qJg����I�(q�	]s	�G�5�#�D���Z��3g�W`��4���3R�*{�!����.;~�������r)�&��@ `\ڰ�C����'��h�{���D�����sg{����N��ӧ%�NJ��F�������I�[PX[�6��9r��M��,Jb���!oH�����O�.w7RWŐ����������7�Ja��9s&Kc�6ŧNn��p��I޺Y�o��Ƴ���mca�HԿs��X[�g�2�p����Ͷ��P�P�סCIy@�E��חf�vwu1N�D��޽&��l�1�d���$6�^����{��t��wn+�v#�/_��ա�8{}E�ZVV��l�w+:�I�p�mVn�[4G��zΈ���\P�ɫg�9��SLr
PwyI_ei�k��n�4��(51�)"�(�	ۭZ���Ǽ��薤1��ȵ�c�͚6ř$���q�@�SN:�R2���K���
^����bv���tj��������;[�9�?�
R(��NN��!�G��"��N-hoߘ9�۾G�Ȩw��B����!��JD�e�o=��NWWA�x�)�r�J�Y	�s�.E�F`Aj�iI�u��a�_<�}z	��1�mY�l�$�a˖�3�ܶ�L�6��x2��(���Y�����#�4;7薃��O����xW6k��@h(������t}�ǎ�'���^X8x���D/�=�U����1hDc�b�x��<z�pذ�2�;�,y�׮]�Z�1H���]'�L83I^~�����r:��3����866��J�:$�%i�>C�i��ũ�)�)L@As���SML��8D`J4�pG�m���y{��I���v�T���z.�s1i�D�8\a�m�j��4i"�8�䶯��J\w�{5��ꔕ��NY�wo���)���#���$�+T��/rX�2����eO�BF%]��	�c?����`^���-Fc���R��ww�n]��CJ��@Q����\�
*�+�����"2y�A"&o�K��=ଡ�<w��kזq�!��<q֎~�a����h���(3�;ʸ@����S�ϳ#��'��䚛Wk�g�n�z�:99Y5��-**�)2P댨������-[H��ErGdD��bW�]TT�|�2�<�Z�ڝ�k�)a8�|�`�s�CB�5[L�I1@Di����7ۼ
,Fc���m�~l)��.��eK3vD3^���QC��S�_�T�ؒ���=�Ϝ�e�^=y�ޞ�Ƴ'ed�ځ[��,gO�6gN�f���Z�Q�?�	iJc@/v��w�n�6mHq,A�ҴI�@?��X��eQ�4�L��T)ƵHo'�o�m߮�G�4o�����ܹ
-��%'#���[�ܔ��tɒ�㵞.a1��_q�I�ٓ�Ѽ{v{�ob��ZpS�?�>t�(�-��9@IB-{;�3gΨ`r�~�����pO�\mm٪��,ݽ��O^�d�{�fX����g�24�7U>�o��:
p���	�ǫ3��Q`9[�l�P��ܩ#�i���ˏ}�-Z���+��t���u����K/to�X���Nz/F���#���1�A`��l��W��c^+���-Fc�������ῇ6`dڈ�ݹs��7_j&�nrAA��Y�8�+�6l���'`���x,bʵy�򥏷��I�ѧw/]��I��3>~���5["�\���2lTjr�7*��>t�v����o�A��F�u���~�ҩwa����PGF�D2�%	P�z��p†R�4�fHJ��͡U�Gd��B㑻�@
[�E��K��NK�j��Y0k�L�d�.3�O�-�^�v굎�F�M�dH�p���PU�/�111��ry+^�x��3�:?�\��
:��"���:6y/��0A����
�iMc�Ա���kjRf�4��n�M�[��
�u�wA� ��bl�yH\���!C�p�]���7paN��Q��?�K���(��T����<,Q�T�88���h�]�؞��4��&��!�U�6�_�����)��&���w1�R��F�&ⶺw5X�<;�t��j����B��u�
2g�A�1�pH;3΁74�����Δ虼|��ŧ�����pwk޼�:��J������Es���ء��nժ���KK�FP���ɲ(7�H��U��CB�{�S��(]2
�
�j���Cѣ[7n\	�?�ϑ��Ç
��8X�z��CE�C��%p���tt��ȵ�^�T��'`!�c괿Y^��8������́���(��Sll�Sa|Q��g�6m��8�	wGI}PxOv���(�@�K/�ڵ!�E�xǞ=z z��k�fF�WB؄������!�]W��eh��
I�rd���C?��c�
k�T�7��Ǐ\\]5jě9.A�)�r�{�����Ĩ�`���$�!B"�kW=�$M�S��=|��r"$���5�kMc�;����嘘��ܹs�l���y9G8D�Yt'ֺuk�U]`��
��9-�~pӷ.�̲��}��1@��{�S��a��	�r��ΞE�oLd�hI�u�	LMMY�`��	��~��۶]�tIo��
T�VnՂ(�swq����U+�����\|��Ξ={�W���|1�IV�2��{|��.r���WN�4i��a
/��fT�y"Te���.N׃���w{q�,JK>����K�$۷:����h=�E<P���e��w]9
�1��
��_i�S�>�v@D�����S�
z�.�.(�7�z���q����+�]��J��D	����!��_�>\�?�۳6��Y�z���+�D��2覍�ƈ�te�����Ɣ�^���Brssy��T���SqLpp͌$�=z�(*,DDv�ӧp�r���F�I�R�������>~x/]rT���a�֭ʽ��)[��P���.�$OƁ�q���C���P �
��/\X��;yD\Bg��a1�1P���d�IR���YϜ����a���*�UqCL�2�����������4�����\x�v\�^�J�e�o�q��H��G�%FRM��ң{w�gշo���ux�`N��_�ư|xl�RQqK���>DdT$���?�
Q��!;=Cܲ�GE��`���x�!@�����c�QQoK��]X��c�|��wf\����ϝC�ls�"���a�~���{q�U�פIZ8#Y
j�H�1_k�i�,ԡC��ԃW�,p�gZL��Ң�����&_e�4�L�cހgd�֭H^e]���x�<7'gŊ(4�o�B�t��1�FFj�>-[���ϧ���b�7q� ����E%y@=����B�u�V>^�4����^8������p�R�P_W77E��$�4,m��P��6m�Y��`r��j����i���Y�s�{�.��%
ɒ6��ipw�As�y�&#��.�>��Q��۷n9o��wu��V�A��V�Z�My��
/�@�TohZbkT_�!B„vA�mvVT��7I|]�"F�7py�/j��r@���8c5�1lڴIэJ|��酅�B;�����ՇJ�&WǤ	�Ih\�Ԝޔɓiu�&�,�O�=�䪙����J������n�$i�!e�ڵ�f�B��3g6��
�)���hP3Q�Ҁj�&���jȐ��}`ń���^��s�~��g��5���L�HkÎ;0+��iA�xs�G�S�h?&w
�m�ҹs'�˛���0�Ǜr��`#*\M@��e�;j�h����R":"B��@!
�W��Bڀ����E��1� ܽUN?���jf�i�QB��a���"51^M��P�ܿ�c]�j�͎�}��Y,v��5j��&�
;p���ɖ*7@��((2�U�1?sF-��Gs�{v惡4v�,��ʔ7̤͐���md���6�ef*���E��4nٹ����X���"DD�.�j����<�ӧa`'R�su��k�Jd\�j�`?D�*$M������W.��v� 9��e�F4�	&�#猣�;{9DJbl�B3� O=J�[�dNz|Ikٶ��"�tS���kH,�.u	���ϝUb�_<{�	�4t�������7�DF�gg��+J�"5�#ᡡ66�;u�4�o�|dgg'4��Fғ�hA�]~C
7<<�,[�A�,{��@�N�|�o�O%N�q����Q6��1Ȁ�4����=j�(��F߈�T?}�Q�Z��{;��5Y�
D�L�Dߢ���h�7qpqq��t�n��=�|�r�5��ݷw�m�Ι�����J�x��cJ^VvBL�Ú5����8qԫs�θt�U"B�>�}A�aM�StuY�p��j�1�TU=zH�c �h�	���J|"h�Q��).>#HNdo�AhMc�À��_4ɀ���F���h�!-[���h\�T��x�=zt�>.��4���h)�*2�$AGo����"\�9��W�9W�f���2�ర����tҥ��֨�H��9@;�/���|�JS�}��7ԡYS�%E�ݛW���Թu86�gg=}T�����si�um�aћb�
^��_��L���
P<�Cz�H�oJq3��Pv�$)6��+ ����(@��ᲸQ`ܥ!b�:��`d��ƍ;r�0����ɓ'oڧO��������v��@(
*��J��4�_qQQӧMC����g�qѢ��d�x�`!}S=X�܃�jx��M]p�V�u�x�,�CN��;�s.��Ç��	hv��/pI�-owX۷m�7��ѣ�Rf����:#��w��g�,_>��wW���Tzˆ9p��D�}�5�:����p:���ܿw7,,�x\E|\˖-M��S�	W�~C�8VB����iSǎ�k�O�4���r����^3X)P›�M�S��ԩS�{M�k�V��_�NK�)
���KՊ����5���L�|�؋c��e!��sQ̀�@Y�������E�Q�!Bˮ^���k׭Ӹt�?=�9�|��P4�%o���#!�?ҽ[7�TG���z)	�yYY*�����5��œܨ���v��d����ڿ���D%ϫ�h�<|�ȭb�z�[�]�V��-׈s������iIuZ�Jr33W>`珸�NNNr�Q9:�&o/nuh���Dj��������%�a���q��c��U��>���K�<�_?��7���I�\��c�9rۇ�H|�5k�{��<q���[R�y��8�W�1�\F��ի~��g#@|������{�T�h�m���[�;��%|l��3r���Y&�>�'���A���*�w�&O���q��X$D�6�gQz�*++���ޢ�E�U�T��7W��*Vy���-8t�L�a��<B��3U��mݺ5�d�0������P3�����j_2,2�"p\��G��4����m����w8?��G����-�z��=F���W�p�QQ&���ϟ�ϣ�.8�⎾����m���pU2.�,�ڷo��e뒷�ڵ_���#+-
i���M
3������KV0qc!�QJ�t�!BK._2���=kj%wvz�����Cߓ+�-5˱ �/Y�rEhP0�Y���#~��}sr�ax	

�zft/|�d�Ӈ!=)QFKÉ��-��16
lD ��jfJ��N
�؛��bՌ�O�V¡��v�y��� ?�<B����hEi@�&M�(�.��������Lȯ+��}��q6��T7����}����ܱu��k���CV'�0�f�wV����Z0y�d�Q�6wJ����DAN�\�w�ޭ�w�'���u�z�.�x����ן���c��]�B�`;=|�\�f�;���E�a�ܥ�7�<=<^+�Y�8O�K�)�Q��^P�Wϟ�,@c""tC�R~��%E
	���mڤ	J{׏v�4YkJ��uh׮0'Ǽ��G�juC����e˖	�di�;��1�A��K�q:
'%����k�:��gy��9Y�)UJ�W	�P\]]dY5#|��1�[��Ǐ�}��`���w�OV2RS�ٌ��:(���?�BWm��nv�D �J��HX
�~�~��AFiJ�1��7k���5z"h5Ū1|��9Atٱ]����ۗ/[I��gΈ��$#"�Q�F�:`��E�����'��:)PAN
�^�E�I_��V�^
�"FQ�Ҭ��
���4h{˖.%�Bi3fI��9}�CsgO�Z������}�
ܸV��+ 2n�oc��p���k��f�c�����w���\�?��Cld�ٿ��;���Ec������r� B�<zp��e|��)�D��O7��>42���P�a�7�Juop�Ff���{�Jo�x�S���N;V)xx��� �u�ٳ�����fԬ�+�ӧw�O���޿}3u�T̤U�V��
o��H���Q�P߷ȝe`� kZ���}�v5�DSc����r���`:��pw7�m�ѭ���c�NN�?&�>M�;t�[|���)�.sww3��8z߾}�'�!���Cz30Q�
Z� �9|��g�@K�u�����x�Ç_�cK�p~8ڜ��KC�^��hd�����4ڸ�i�(�tI��@yYiFJ����ȒK��	�-Q̤�y�4?�W9xЗ��ĥPX�p���l�N��1|��͝�I
C+t�2��v����殨<O�ecLj)/�D�����)7xY��	���s~f���O�~&%'/"��]�:��,��ʒ�P88������7�J�p|^�|9�iѢřS'�}�3(��au�S��=�'ڼi�ӧ�x�Bܿ{G��� 7�j�ΐ׾��T���(؈�ѷ�k
�����A��[DJUê1|��
�I$�{$�K�^z�
}f3�b
B	"�k׮Z8f��0q��|A�I����]�z��{��===��x|"����;w68:�^�;"A�q��:���%�;u�s�4.5^尰:�m@�%$$o탂��f��x�ƍS|�$T��o\/I��׫��&�W=y,�peh�O?�QN�24bf��$�@�V�r��������Z(���Ec�ۧ��~5yY����ӧh<>e�:}�n�t�Y3g��mx�/�?�ǯ�]RyY��������$��P����$3*2Ҍ���<�a�b�g�j$���w~�{8�����N044��O??_��B[�"�ұ�k�С����J�A�Ӫ7�“��VQ^&��@�I dΨ�f��!!A��%�'TW��_[�c/˴�����e�=g���H���w������ZA'A����ݫ{��]>{&:<\���f���W8����1Oc~A>oJ�UU:���g�V�=�Ds��իVqF�y�抠���KW_�z���G����22�k�G\t��Y��w*���+0�4�h���"8`�*_���6n���l�찦V���C��,O���j�C~V��s�.�gX����8r���P��׌�1s����D*�����׮�}`��JM=w�t��=9m�]�v%W��e>@#��-)�C���ϋ��x��%�pj`'�������%��<F�US]�(�&�ai#�A�${pܸ��XƲkWQiV�E�+�ݑ��(�/0ۂ�oq�۴n��G�uΛ7i� $�B{Y�m�j5���@���噼��l�/$^6
��`H���[Cw���z%���yĴzv��
����5>��C��nhA��'ubb� �"+r��H�?��#8(HbHDaa���[t�@q&�I�Z�+$����w+*R���P�.W/�^�����Uh�{��-����Q�BHǕ��P"V��Vcشq#w�̘ n�6�{"35�>N�2���5��&g�f-%�ܹU��O���[�&_,(���3�.�5���	&��,��~��Ʉ�y��͟~�����;{��$�
5�z�r�ƍ%��f̘���W/`�W=��7^��Z��&-������A:�=>/��k���i[5�Z���g|h�˽xn�;R�-&�㛗/R���CU��c�`bBC�h�� �o"�~���a!��~V��s��e�@�>�ٿ���{�*M
����7�Yr�J���18k�J��ّ�3gh�Y��QQ칎e؁6�_O�F�[��MfN���K�☝�z��-�
"D�����S�B,�}�?��rs�Y����`�ˎҟ^�`���%�߽}#�l+���"�u0/�����-��0>�[�n��%G�	...���9��٥�u�<}�؋g5F��W��'�3W�>|�)9؈k%W۷k�YM�b�����n� S���7�����d�WTT����\h߶��u4� �����}���LdiѺY^��sm���k��G^��&p	k�Æ
��^���C~R|<'����E�,^	"o^������������gr�HeD䗈bT��?w� �����n�M�q��!BP�N�<WWW�k�Z��/_���K/r�U�
ދ��@2�ofJ�����ښ�;v��\b�E�����^^Q��x2��v�Z�3���ʕ+�q�P���F��"���o�����.���D
V�!?,$�;�#G��aP���G���J^���ܽ��J1�j���`�((�U�죇��ƍ�^��K��~���9�o���H�k��?�GG�:U�XU�N�:i����x�ؘڂ�#��|�=�	���ܽ]A+
�*
�?6P�hK� 1�h��?_C;���2z�H:b��f�ʯ�X�늈��3~��cǎ�8`{ʲ�����o�\W6"��o�6p�Y�	�TlT�%����l��γh�B�'\���ߣQ�@<�s�w��<�"��զm�6�O�Q�e�n��q��������>�w7#%����{i2��PS���g�D��1��o������#"	����MOKca�,m&N�H��{��)C�++����6;o��H~���mHQ@��[����o��v��YY�H�`�^�F;eP��i��Aǎ-�ϥ�Ch�sfͤ�����C�wP-=�֒TV�!�e��8 �E ;A\��ׯ��
n�[e����/��"--�<@��ߓ;a��,�F�9���/_\�t16R�6{�j�(|�`Uz�a6�����]�`���$fQ
:��������ډ�'��-[
���֬Z����
�>H��]Ԧu+��70��ȍ[�nM�4���ڹ�`�/X ��l�d�5����Ζ�8v�(����|�/[&�{�)X5�|X9�8|���K͌��^�H+
�4�,���/@b�ѽ�I���0�o��|��]�-!11�3;#p��4a�Yv� ';
����Ҽv�pA���H� 4O�>Ł�[��RY�"��8�ٳgӼ�vB|<4<��8?{?l��[�yٲ��[��&��	�X��W/�b�ҹwl�N����3g�l��NIIi%PU҈�A�5s����0{�E�Z<��{�s�j�(�̝��r�	�/��:z�gi�{�?�ƈF�妁����p)�����%2X��������(l���s�d��3��A>I�-[fA�e܌��Eq��z-[�T���x}���U+�
i<���P�Q��B����ڢ��i0�q#b����Z�H�1b���j���Ix����^B8���%��8
_�Ɛ���I>��k��t�H=�ߵpX���R�
s<hPvv�����W@-���0�Rv�ݛ�H���Hכ��3u�@Zb����k%�k�������L�C\�|Y
g���֬^-���]fL��j����!]1w;݆ҢEs���ի�9�`SG������
�	J7��("q�һO�:%80�NX�>u�e��lq��	�Cā/UwQ�G��>�SG���ҀZ�}E�M3fL�|�;��ӧO�N���Z4o�����5O��<z��T�7��$%�#�.s��ە���/ռ�i�&CR
��]۶�z�X�x��W=�@]o��={V._�13ԥQ-�6k�����W�XAH@ED�E�Ҁ�ZDq�qcF��R���R>��[�|����(|��ۿ�vvvf�EL�Ƒ��z��A�&Lo��P��5�tٲ7��D�$
4s��������>�!!&�P4>��C�w{�Z�����t/-h`,,j^���Ŷn�jͪ~>��
f$[�,�������J��j-U&� ׯ_G�j�7���T�"b��j[JK��ow���.��"n��_e(�׮1�L���?�F�໖~�p>�N�g��Y2�pHdwq�a��p��Q�0iҤ�)OLD���d��S'��b������˖M�<IS_���UDx��5l�P�@N7��L��ς���eK���W���ӫ�>ѽ'FW)�vjJ�肟�!@���O��m&M�9#��0��ݺv�8��	�CaNn��
���4���#��g	Jä����4o�5Hy!i�Y�V�`ݺur]֌�����Kg���p}E+xֈ��{V,_
�b�}����>܁�	D��F�J�k�A�\۶l�ݻ���Y�:v���E��\8�8�7k�l�Ν�Be�̩SlzXm?n��-[�X�n8v� R� ;G�lY�j�����䉺To�#��f��=v��瞘<��a��xe�Z ��QHH�|h��Pʤ<�<����T_:WÃq��B��Ν�7:�s1r���͢1�~ŭgNeg��N 
��4Ҁ]0',]��
��͌F�ƍ�deA��TO�6�V��.]
#�D7�1{��9/Ռy�����+W�`�Qsɡ����ǯZc�JM��iSN�̒qn�ڀWt�sO��T������㎾v�d�g��#�?_����fYib\,�&��D�����$
N?n��a={���*�)�1"���	�_�r�W�7�U\3�W�i;�m.P�V�МbG�6�f��0�q�N�<��+ZD�7
,2Eh�8�-\R��e���M����kA
�,YbY��5���8"�O��q@�>��w�����;x1
k�:(��X�	����t��7)�4?{;�]�n�7���������i��qM7�(�ʰ�Qc@�"\E޿E�Iō�㇊��i���k&�={�4s� �@Y�sr��ϲ�2�t��`N�0��k.۷�C�1����sML�q�r�?�D���x�&2d.K�,RLtt�֭��qcƤ%%Ð[������~_gXز`����jى,Y��!.t��%N|�<���\�}{�a�߱u���U��#T5~D�Ξ9���c)��G�^<�`QVZZ�g��u�0'�έ�kV���W�4w��]#*sR����a�Z%e�&��u{������a����;z��Sh��z�O���V�XΉQ�>}�Q�P@}`�����������f��a��9�hӦ�B'G�d���O>�ewX�UO��ج�Hd�;{�R{{wWd�"����⺠lGjB|Q^G�_�0Sb�G�L�Job�,�\0
�LԄ��{�g!K��!_�n..\YN�7�3U�,e+��3��O�3lA�j�a�U�nۦܹU�rQQ�ϟ��t�
�]bL=�/���GG���U��3s�L�@:e�0�\ݠ�~˖-����{J��8̀�0��p0/���շ��x�8"�]fl+]<�Sx��>ʗ���aC��$0!&�w)!]���� c}@��E-轗>կWc�JK'�(>!^��T�³��E�8%}ܸq�'Ӑ�a�b{e��%��!�-_���K�' ��u�үO肀(�E!b"�s��N;ZQ^���ϪQ���o��S���͍qQJ7CM�͛7+w��4{�����z}��i�sf��&��/.c�մ�S�?�D���b���X�O�C+}X�>��3j!ΛݢEƥ�����ڴ��{�~�^^r1_v:p�Ⱦ]�tA����uk� ������?|�'��J�!�43%�(?���S��o�}U��P�"�@v�)Dp�EBW�h{@Y�h�B�ł�3�k+���|�	tݱ�_�w2f��$z�O���|v{	S.CZ�+��Q>	3�^��>�H]�{g;35-7#�����r��4<"\�]���<)�
�|��������\���=�?���Ŵ�[��㘼���)תe��[؆"�27�[�����F�����2�DDh
rJgbbY��0�|��ê՜|t��I��(��J�'O���΀���u|�F$R�Ґ�����Bٷ�ʹ�g���n��qu���+R���ٕRE�����%���=��E�y��Ŷ�[�Dˆ�z�
����D�3B�픚���D&�����k��XV�j$��g,'͌mP���ݝˍDZ�b{{褉1��'8K��~��n`�l�URzM�.�͟����ӚƀchA0÷o�6�ad�"�W�����о����s�@#ú�u���b�z�^&��l%6�6��mm�^�a�����&N���S���vE��pS�'��˫PfN��{��D���D�����Oѐ~z�id��qVkPc,�]]i�9sF#��;
$f#h���������.�7��C\T�u�+48X���X����O8U �^��`�eV�������w{�8`�n
�P�K���}�_x�<<4t�����9�M7�,v@Ä~��_�Ѡ�0�3��E���R�y�p�Bx
ʁ���9gԈ~{��W�NKJ���QF�ĵ��b�ȑ���I"�]q���^_���&�v��j�(=}��+7I�#ƌ%�˳4@"CC�y����:�|��K�AZ�j�Kk�����T��5�5k�(�j��k&���8w�X7m_�@E�$�Z����@MQ�^�˗["4-�8����|�þ�r)���j�E�i��9�~���K]�l�|��`�/!NWXS7�[kނ�R��nݺ)QYX���|���4�18ou�"j�]�t�,��4�'OI�����}y�� /++
�_?�n�����)fC�5�I�X�[6k���kz_�ƀt $�DE��L���rÆ
;t�������� ܽ[���(�6���Pg�]�����z?�	��,z���G�W�%�jj�w�A�!�R��"T�Κ5KM��2|d�F��Қ6m��)�x�n^%�'�:�r� ��xM�DF���G�!�?���0޻w�3���eR_��@oL�F��&M��<qB�y��oRb"}!�H�Y �0!�_�/��0�+ 2,����TˡC�h��ء�E����hPcH���>߸�;V��A"k��\Xؘ�ѐ��A��V�l%�đ§ˤI�
Xi٪eD�ע%Л�Uk#�.\0���{ɒ��ϟW�|ңܽs{��
q�A{ݼq�������\^�%��C��JK����-�7f�hR�H�m5>btt�fy�A��"4-nCq�hM��'6:��a��?w�fd����Bv-�GJ�NWW��Az{z�p9+�^q�C��]��p�a�KJLx�R�ӎpeT7jԈԏGuq�)�Wjb"�C�H��#i��YXZ;�6�'���������t�A���X��_��{!��lwvF���7�`DA��g�����ҹ��O
D�O�޾{|ĭ���j_4�(Nb���I'�'L���.
J
6��R:d�`XI59���B���v�ЦQ��'V���6)�})[D̿5�X���+W$ʉj��ݻKBq�/[����v��s33�N�"����1B��s�.v��ju�\x��b3�|������2]�ʣ�"y��Ú5OM��6IC�M�D�喻���q��%%�ε,w�P"�P�ق�~�32��={V�GӦ�Dz{z�p�f*�0tM�e�տ���P���P�;�!S��r-��Uc�kdqBz��AG��X���ꕷo^K<�ϟլqp�E:�H�%4(h��5?�T�7�x�잪U����o5� z,
jpZ��__�ׅj��ӹs'�Iy�Bm��h�x���i����*QbM�<3v�ݷK���z���BԬ�A�G�
�#M��������Y�􉸓���ߺU+ZpG������� ��C��͵Y�:�ƃg�f999�I�^���3;sX&�A�Ũ~W�[��Wz�MiY����~��/ZcA�zq�"�� �
u�DoK�.]���)#[T#e��i��)�B��0no��̌�_�'0)i"?��h���(<��~3U	�y�~�cFY��<NZΞ=�ry����秏���$עY�����7�U#�Y��'Y����|?0^�5C<��+d?�2x��Ν�-��j�5������n��no�ϟ��C���R^1�F?��v-M�f����ւ"�oݺ%�T�Kvv��W�5�1`wZ4VwQ	�0���K�
Ow`�?�|y�^�3,
�`���3�\�ps�o���Z^�F�f�h��"$(h��)<<2�b�>,..@�3����֭��ha}�a�PMz`�
�Ky��tsmn!
�\�,����2>9�m�M�a�…�e��H�z�J�6���A��Cy�����Æ�ܵK�{F�@��4�}/��/���M)�x�t/�� 橮-Ϻ����u���7o�cǎ�W�@u�i�s����I���������iq�aD��m[�@Q���}{�E,�*�x��Qz-Z��_i&H��M��q�F��R�;���o� Q"�x^]����S<���
Xlg'��P�Wvz�ͤI"����׳G�m��֜IA�e��h�Ű���O���86n�_B��^H���=<�ZV�U̙=S&�i��n^
:T�5�N��T�KS��65���p�8 q x�Ϝ>��P	��r^��ٶ�qK�<a���Č�a�Mpg��Ys&El�Uc��1p~�?�qcǚYd9G����$3v��;�������n�ܧw/�k7K�3g
�C�l�}
�e���c�7(d�-�c}x����C<0ǘ��e�0�nq�	�.3�<B�	&��
�ճ�˶m9B�[�s�jR5"I�{�v��Eoq��~��YJnQH��lm�C+T��s_ ��ۯ&���
���Mޞ�j�Z��!n8mj.\�������aZ����?��h-r%������q	I�
�*
����*��-�ѷs�Nn��f��Sh�*��j�i�9���C���;��-��(�	D��ysyI�#?�Ǜ�F64����������u�F������-�,�Lʃ

޼z	|6]Oı�E@b �x�6֩S'�_#���vwq�}�������(��V����D5��5rD��ݡ���+�V�OZ�^C�����뽛gl��z�N;��^����]��X��UO5�"��Ц�����vL�8Q������Ο9�˟��EQʲ���D�c!Q�c�]��YF��;h� \�C�qvr�j�L��L��A�A��R�&4�4t�~j��z$b�:)�����~ek�L���'N��9�ЬƀBҌK0{3�^��"m��{Qaa��Ϲ�Q��l�-8��GG��XG�2��Uc0�u�u5�޼;v��鮛F��C��JK��5�1��/qi�u׬�ЧO՘ }����^zY#�1/33"4�w<Q$�q�#�s�%{zxh����M}X5��`���`�+�	5m��^�4��}�V�6#<ߙ3�e�ye'�l�r�j��f5���IZ` 7�K�.�.EF".���E8x�B�gN����8p��6�����#j�V���1䀳��;��p۱M7"z�ԩ6�~�
;)�Z�Q�fXr�Qi:(���Y
���W�NK��.#���"u؂�z��nQ<�&$|x��e7�J9 ��3gi����M}X5��`��'�}@�T�.�}�<u#"]wl�٣��W0��7�Y�G�ۼ{��e�i���7KKU����4�F���*5�aZ@⃮q7��h��\�G�6m�+��P�7�:��9`���~��f���}����K�,n�wծ��fp���=|�$Ծ];��s�a���k����k`�K\����hR0�4��p��,:�� �����'YFA��ۃ??��cvZ��0��T�Uc�j�9��m)W�o��
�z݈H�5B���YM5��r��7�0V��(�����,�^=z@i�<y��U��ᐛ�GӦ��A��
��>}x���{֐���ų�'ܣ�
.���I��*�I�����`��s 48X�]��f��A@v�uRl޴�M����[GT�[�����Æ59s�7�5sfN�$]@��J��C��f\�B�B�Bf��	6L	����c��<�gh���BM�/^�5�-*<B��un*s��1X5����kQo{�
�֬օm@D$�!�*����P%�h)4<�ߩSGY��(�%���ky��f�D�*���ܮ���}�?[|�I�����^QV�E�W�^����?���aeldO�"?;�=[���)EDF`��|�M����o�u8-s��1X5�Xjo/�uY[��߽v��56��r
D��Z��w�p�d�o��.]:+�p)4�M���	�@���?rߝ���륋�}�X��8�+jܥs���޽4Z���?��k�������G-�0i�]�|���ێZ~��sS�V���1��ӥ�=�}�9�f�^_~�K֮Yݼy3y�[�t���R�^�Νm�9�?�
(Z<�̔�iS�Ȼj)Ԛ5������~=�#HNJ��eb�~ڲe3oi������h��(�ׯ^�,�x�O��]�p^7�1:,���S�0E��w�}�RE�7�:��9`���~��*�1��Zb������a5l�z���ɾ� �]�_+!�t,��}#�F��v�-b"#Y���N�a���'1!A�'��akgG,
۷o����C��Ah�w��)�҅,��ޣDl�
�zr���E7����9sf�H���W���`��s���P��guYA��B�8���q#"#e�CELKMi�����y7�
A�(�'}ɢ)���'%!������΍�a�<a���a%�;�u�m�&��W�l^Vւ�sEs@����/�n	��c�!�AWɆ����
#x��F�z���V�>b�`X[6xX5�Ơ�Q��Jߡ�Y[0onp`��=�H���F֨��rV���R�K�}a���΂��d��-c��](�11�P����]>v�hd�
��<v���,P(����s��'Ԡ���HE����:rJ}6���v�:AB������Q�#�u�x����hdJn��XҤ�ʆ�}�Uc�jz8�㽛�������N
��0}�4�e��QV&肖�1�ȅ������Z0~����h�B5M�k��9W��/0�[`�~��� #����|z�<;y�D�y���-�cK��oh���?7	�]����D����b�UW��p���e��]�}��i�jV�A�̞-�ui��.�;�Y�*8@��
D���6�K4`�ۭ�7��R
�Ǔ���I���%�1��ؾ�ɉ���Xqmƨ7-��j�' >1z��]/ʔ@;J&ҥ7`�ںys~V6�����8�(׫sǎ0&���RoXz�JFJ�.��==X��JubN/\���"*�
�`}&�p��1XE���[��S��4D�wK��|���~Z��b�Rܹ&p����7��ހ`@�K&9j�Ȍ�Ƨ�kбCE��=�
�fe�q���E�С�������`Q ˇT
�j\t4�s���M���˯_�)
o^�(/��W�㣣��Dx���z����������o��jV���w�h6�!��Ç
��a
	�\���£��{7��wVw��V?}"����q�,h�qw�S���*�C&�TD��P�����a��~�mTT� vэ��<n�8�/ӷo_A!��3���]	���r�
���k�.qJ����pA~DH��x��Ϋ����k�7g�p2J���Es��1X5>2S�Z�h!�Z��jg8!z�Q�F�?M�0����ҥ��17#s����?�n���!�\�K���k�:&h3};@հ[�Pv�|�Νa�=+C��N S�qÆ��12�4�s���iZ�pav��2H��b��ݻwۿo��#Fp�Ұ����ӇèW�3S�aux��PN��~��ZEg¸q�����r��1X5>⣢e�D+�
ܼ�!�zo�?�ѣG��ۯo_(:�>1S�G�A�&����r�7�_9;o!�����r#�tw�1��
��<X֒��ҭ[W�+V�C�.|�^+�ڮ]�����i�q��AY�̞9S��I�uv���k�[.�g𠁺����2=%���F�)�,�sq�!�馳�p�ڦ�q��1X5>|���\�����H��+�Я7��"qQ�R�
j����z�n/�n��T��FGG�0=�w
>�[�l)��,@M)��Ii���F�l
:�1����ÿ����e"
���O�`��u�(��-��O7�4%!����0��|���ų��Z�"X5d2n���5;��Uc�s`�C�i]�-�t�͛Ϝ>m�n���0�'��e�g}�$?�
̟7��/�L�r��E�W������I}Ů^�R�S
��	D�6�e�+g]���d+?x._4��}����8`@b\��ă�i�p�桠��ǎMM����&&r@ ��̉��O�(���z��
L\��!1�F�
�4��Uc�s`ԨQ��G�Ϝ1}��݆>�p/#� '��0�
���DՅ��}�#������iC)ٲY���+W�(Ո.۷:�|��=�PϜ>�7��۷o'���iӦ�g�	e\>�����-��۶��ࡅ
�ע�e�Z��P��$N�,J� "8#�V��&Ѡ�[cmf)�jV��
sr��`D��:1.6>*��]�CLdDzR2�`�wrt�hb����+�!	��û�C���a޽k���[<?��~�є]E�l�WtVzo:�|B���/���x�C��ٳ)Sl�,J��;ڨ�	>�GǴkۖ���Z����J��������H�W�'jGi�n�z������]�ƘW�C���o%.��Uc��؄ݒfi���w���)1&��Mm(YHHbl,\�e5.*z̘�^�(��y�JKI��M���Z�e)��4D$:"����R�^�o�.�E'c�xnf渱c�����O���}:-�m۶���Um��j�ѽ��r�h��Yi�H��k̈��".*
�ȭ7'=c�	�t�f�j��+�bx����YH֟�V��z�q �st4~���?�a�P�1�^�9w��\EC�s��q�s��m �Y�N++�O�߻��/�p����_��y�����xҨ���,9J�%,���p?�ŋk1
K�Ӱ��B|��9C˄o^��}qL�%�ţ��q	��R�Ym��Ivs�o�Jߢ��p���0�°
00��"�l�(F$F��Uk$�Z�c�ZM�w���j�$O�͇6�C��Il��I�|�{��8�̝�;��y~�0s����s�[���ʥ����]]]�Y��5�� �@��޺��Vò�ҁ�x�yka��<�iڏ�9C`fc�%o�|8lAG�{������/]�(ҳ��P@���zFB��)�I�iyyٽ�gbM=��{gX��kinf��"")�@I�?���;��G�4����4'�i<�Z���
�i�ff�\��(lFz�_|�S ���~�͋G�(xwQbηMs81b� ���c�3�Ԙ��g�F�������a�;4$c�v��2^7��aO>���b����56<��k����@���]�����@nR(�j���u�_�>����NC�J�x�sOa~~��4
������ԚJ�5�ut�u�ч����S���~��ӖS�����8����A�1{`�E�H�r�+�Z��N7���/�N[�XO�xl�]�:���V|Ķ]��fm��,��{zz�s@{��c�L�k���!Ȋ�g��Z�4�^�`;���`a�<(�k��㩸��D���MG\��N6�(_1#U��K��655�tw�zdGE�G�0
�^���y���/�	8�1cX�q�X�L��u��eee9��}�����	����N:�sÓp�����������g�٭œS���9�f�]/=�������{1O�署;���'3`�=9��o
9�WO`p��]/����Q��ٙ���IOp,�p�J��.x��wBd�Z\\L_V-��gN��b.2��å�1b�8����-��;
�b�O�UT���U�Iu��ٻ9Ú����'�?x��`��䤕����tgzF
O����VWV�NR���>`NV��#ք���c	t���E�>�z�}�"�l���"����ikn�C���=��[_�\�ܹs��' I����#vR���7b�!�����)E��h/d,��@A)��qZ���%�[#����^)�UVR�!������@w���JďBpx7�x��Y�r�����ಾ��ׯ^e^����ԯ��aF�Ǐ�zn���}�j)M�1c����g r����_���6Z(ɱ�9�耇��+�/���g�l~�?]�s0��'�,�������������|��'^�4��믄��&b�Í�sH��b����:�.���dgL�93X�p@��K}�1�)3V�`_/v�yƆa��KD�y�~C��y�N�768�t�1%`�B���SpQ��l
���{+�4"P2�͞Ad%���#e�r�1b. ��G7�]���1�ܹ��kl	�V�����
��`#��GoQƂ��~��=��C�`�0pb�!�&�=��
�m�QSS͞5xh�>}��d��񇶶6a0�|�C��6Oƚ���\�/}1�xNhq�9������XVZ�L���7h�bw���^�+���吝�s���J� 07��"�A���p�N����a���ܴ�ݶ��+��,����>��;�,P-<|��� ��2��"I%ꉯ �@��M�J�<<^$
/>������-DZ���r���Pb�}���@h}f�����!fIġ��i�$�;iQ����cMMM��j5���A�� ���~)���C�5�¯�k�����v�76P�+���!����c�F38Ճ=��WN�l�i�b�H��pG061F>_�	-|Zeۋ�r�u�e�?��_��Ņ�kA.�kn�3��eG����?c؜K�f�
�*"i��8��

���?;�k-���-E����?�=�-5��C�c}]��[�)��b��L.�a|\$���ǐAC��:�˹���=|�)i����={�=�Y������S�� �@��`��u�\U3@�0=a��C�{l뚙���s�x`.�0p@P���/����`��]���k�a(��q�	���5��$TYNɅ{sU���Y������i���G�� ��;/_P�$�	T}#��2�f���E$�KG�
ig����=5(����Ê|wz�������.����7��@��6*�A��H����8��U�54�o�D�s<k��	��3g~��Ov��_�|z�d;¡Ѡ��ʽ�,�5a���F�1/#0><b��r�LKXs���}��G���N��3��(���
�o�N���6����^�������	 
`]��[W���JF�KKJ�dҨ���R�ݑq�7׮�h��i�
b^�/�m�y���^��tM5^z�vvn���,^
�89:&&��j���8z���4�@�)x!��E[l!���p�cP�+�1P��/`������������X{kK`�E����1�
D$VUT��l��
	��׻���
��`����?\\R�;%^��3@��MŐ�v���9i��q��L�oߝ�F�	K�$�pcg���_�la��Gx������F<q9��=�+����-uc��~IӋ!���ߢHKs���� d�D��y-��sÊa��
���0�fh "��~�_�v"���b{�pBx��P�Р�r��2�8!_"r�ծC{��u�5���������1b>Gf�[Z�TWߝ����+
A��'#[���'���c�H
(���`����r�j��rf�´���8Ύ���b��It�K�0>���ℴb�0L���Z�`�us�!\E���KW�����~o>DR��1�����v�=��XlX0���&?! e�1c �«?�<�_lc@�H�`�UX�{��X�1���-h*��~����$
	j%Ô�H$3�0S€�rޮ�VƓK��_W�uᙈ>����}}�}3���f/!�c �@#���-V(*8{�8#�Q��7�ׁ��}?881<�f(ͨ�Q���G�&W ��������,�A����/!@�U��!@�!@����A��'!@�!lc �@�!@� ���`c�t��!@��1? B� w �;��$B� �
b�B� B�9��cl,�� B� ?��!@�!��cp5➄!@�@�!@��!@�!@8G`
���?� B� �٩��k�\�����'���-��[IB� B�h=vt�1T�_U_Wy`_E���e�{Jj����vVT��Z���
�r���Ҍ�fCT�6,B�3��P�&D�^
��)�2�N����g�p�s��E�ҩ�:�V����p}X��i��Z��(CxT/�����$<*<�i4E�MI���Ԝ�%Y;vo/�����/���]W�{A��/��/\K����YJks�*�,ʼn��q�YQ�dC�I�X�e�6�rk�B�m��%�)CVD"�(C�Ȕ8j�L���%T�%����E�%���
�X�J�T�TKp��0->k�j
`�*Uj�B%�C�2&2^��e?��
�B�V*�*��Vi�j�F��B4Ltv���xѪ9�?�ׅ�L�nhuh��D��:ÉJ��(Sp��+ !�Lx�s*�j+!�6�_��p�X�"T�d����5X�_v����CB��8�1�*�6ٖ5e�Ή��U�B-WB4
~������6D`VGDFGDE�Gb�F�1��u�0�Ǐ '8����U�0�Πх�//a�Iц��z�Hc�16:�d4%Ę̱�渄�8s"�7��7�p?��LF4���g�&ܿѱq�����HtF��8jUL6��RQ(C9Qɔ�p�����a�OlXe+`.
�L�~b�8Y9��L��q q&lܹ�$	�+�s�N�ׇZDdTTtt��k�7��I)ɩi���9Y9�9��KA$���=ϒ��=3';=+353#%#=9=-)-՜�bNINHN�OJ2%:sL|�������0�.�6�-W�;vY����q�)�����LszNb�%9�0=��_�j�^�>T��Hy����[+�W>Q�x��Wl�T7�Wn�j8�fh\Z״����ʃ��}9E�婹�I�;2���,�<sf~bVar��䜝�����A�!e{�YKv�p~J�)B�T�����4d�p|�,ܝ���RV��i,�k�}���P[U�	tru��n��
8��vG�B5YIEND�B`��SDd�-����N�
�
C�*A��JBD_Fig2��b�S��ؤ�(Iێ��
���R��,n��R��ؤ�(Iێ��
���PNG


IHDR��?*�sRGB���gAMA���a	pHYs
|
||wtEXtSoftwareKruwo soft(�a�RRIDATx^�_�]�}��˥4�Ʊ�ڵ��ȒF�X��(`d�8��PYq���}P��:���8%#�Έ(p�@S��n�#zۗ���q�0�>�y�`1\L0B�#��9��u��3��}�^{�?_3��x����������p[��������@M�CM��-a�I " " "P	��P�!	���HXԆR
������HXh�������F@¢6�jHD@D@D@�Bs@D@D@D�6��TC" " " �" " " ����
��������Em(Ր�!��zz�ş��ο�~s��;�G{�=�y_E@D jQ�O������û�<��ć��?���ku}s��]�^Z�M�CR�D@D`"	M�G`�F��Ү/o�*\�˧--wn^�'A����1�," �HX�"�vE��߬_|v�ѕ����=VX��X}q�H!��HX�g3�8��S����]���́a�\[yr��xƩ�����# a�� �l^�t|!�ys��OY8va�栮�ݕ ��\���E@D�	l�r��Ή�%!�����YV�ow%ȡ7F�@D BM]��@o�G��]	R��HƮn��dK@�"[�k��	�z�[A�-wQ\��o����x" a�	����B��s�C�c�h�����@2$,�1���B�ᵦc;�����N��������t�L$ЭWQni������]B." ����B�_�n���r+H�kMGkq�:p�[D oy�_��Z	HXԊS������@�$,�F/" " �������v
Ur�?����
��կ�\�ryu�~�}}}����c��-" �$,"��l�������>t���G}�O�{���'���G1����O�x�׿�u�T�E@D�HX�>L��N��_?yr��}��s�G����~k��]w�y����-��꫒>
��E@�����7��%,��}�ʷ^ٻ���>nb�ԃ�(���}{��0�����������#�L��E@�����6��%,<���ի>�R��\�������bR��w�х�W�$����6>���$dxꞚO$,<���Y	�B=,�ً¼8-����]��(S�:��_�����N���9�����O$,<���Y	��ME�����QAn��C��I�����c���qi�\hA��`�T�" "���'��4+aQ��LU )����b4Ub���?�G�
�v�<� mQ��Ԛ��?���Ѳ�E�v*�
<
,�Ta�Y����"mQ��Ԕ��?���Ѳ�E]v"�A.��Pr#��bb�<hQ�u�V툀��'��FӬ�E-�b
b���ɪ�˕�-���+�D������$,���󛐔��KK��(��$,L[X��E����M�D@�����6��%,��$Z�"ր,gyj�U�
�,���峾��	�Κ
Y���E@¢-�\W�bNKPۊ�Vv��>ʼ�gE���P"�V��" �HX�cG��؉�WdT�WQ)H1�������*�5��t���?���Ѳ���v‹@�md?P.����ل��QK� �C{��l;�("���?�q�,a1����TA�
a�ogfa�%H�p��s��_TG���@3$,���U$,f�
A� � ��5�<pn
�P˻If����$,�K�x	��,��i8ݡ�ء��l��Y" �HX�cG�3؉�K),a�?[�G����m����+�ze�!��D@���h����j*��	��Pgz�A������w}�DN�9݆�UǢ�E@D�v�#��A	����~����i���m�p<b¶&!"C��Z�)" "����1�)aQ�Z.g��ʔê�~��Y�B,��b׆�<*�S��dE@�"+s���E��'�y��ae
Nb"��4," �HXxM��MU�>�0ʟ�����mS���ʕ+�.��E@D�$	����=L¢�i�]���taw ��E�E Z�<O)"�$	�$�ZaP%a�$�
��9_��T��-N�΄#wJ"�a" I��HҬ%aQb–w��0���^aaS<�����a" "���'��4+aQ�TEwE�mA�6^���,7E�P_���]�R��H���E��>:	��n߮�]��j�5��N�'��!e�cD@�����6��%,�ک^w�aa�@�XP]�ML��H����?���Ѳ��T;���!,h��
Jpⴠ�w+UƧb�" ������;S�b�p�+j�o��PCx�w9�mK��o�>�5~��HX��>�+KXL����^�‡�`�d_4EC¸��ȗ��E����KXL��3��̞�vE�*����YA���\�^�E@z$,r�f��=Ei�9kW4 ,�����ֆ�~Kk�"�6	��-��%,v�)��a��z�%��0��u�F�J�3T�����Ed���;!��믓�`σ����OX���ˬ
!v�JY��)jPD�$	����=L�b�i�2�����>�x,�GQ#��o���C�P?E@Z' aѺ	Z�XP��jY~�O��g?k�H�/o����B���ƦE@�$ aQ'�ے�k5���$_�E\�o�B��4�	�>���N@�"v��	�Q�,���ɱ��k�͋������r��_��W�^\W-7�~HX�N�TX
$E,�+���@R ,��^�O��� "�4y,�&�$,�,����X�b�Eh�*ӟ��=��e@�$,|P��M	�!kQ��B	��jrN�g��u-�!�O		��p��Sc��}>��Q,��E��Q��x	HX�k�zz.aQ���tl�)�f�i=�oy�Ym��H�9�3�E@j# aQ�H��(//�W�M?�
�F:3�m�H	HXDj�ں-a�P�͘�2e=i
�!i�_Iow)�-�'�cQ�" "0D@�"�)!a�f���tq�^� �'k[������_D`���E�B��f��%���tt�5 ,��W�>�������A@¢
�!]S�¬�� ; m�N�&jFX���w
�jP5."P$ a��|���`��PW���A�Ds��4�2��-���KXl��[����΍vm��z�ד�S��ds�?|��-���_n|���{�O�B^��q�����X}�����n�Ҧ���a��X�hH-��(O *a�y���[��s����Y��C���C�Wߓ����Y���� �	�
qUD
�9�Զ�@�@L�bs��	st���x�Me!�E*��-���M�k`X�	EC��.!"0D "a�����/���,��Ř��PH�[��C3�@kC★�$D aq�sv��X���'����^Z�Ͱ-���W�n�\�\\~�r2N�\^������1�?{��~� Ov8}‘[9���V��+.�eH�pI��;i�͍���vW��^Y]�;�Xl�\��7W�I��yj�'�Y�������&��<r�aECJ�:DD`^��b��[�MH��~I/���_m�=y�ڻ�.>�����ҩ7�9m1���}����9��5���v�����ɳ�>>��yc}������l7[2��&o_2潟ʝߤ��@���D�JY�죣D@�"��x��|�兩��y
�)��$���N9z��ũ���f*d��P���|���#�b@7�U!nt�?NUl�.νe�����\XX�M޻�-���f*}r�‚N}���8�
PJց" m�CXl^_=cq���
�oQ���������s��j�.�BhAX��X��i��+N����X�
��T�����]:|��+
�M���?���"�b���| a1�@��f3i�����'��2L]TD Q'#��Y}�^��ջ����{���u�ŵ$��J7!cH�8�Ė�>����@	
��w�S+o�I�=[�~�e�Û7�.�'�?�q�.g��{�6Pm������7_x�Ş��" 9�AX8Y0��8[�O�tԕr�dTX�y��Q���AXl_���ʓ;d��r�91�c�ៜ�E>1W�s7����1����@X����8P��e_��t��"��5 ��&�ň���h�Vͪ��h��~��!쇂��	����@���ٰ�Gy��ŨV蚶��X�
q����YB!3�8��c���w-{t�6$�'��@���l��`5:�v	/,\b�rJ'5�,�t9T�����B��sΓ��O
YX|�ҵn���ƕ[�J��(8i����K���x��Iɛ����R�Zt.�\�T��E�����l9Ƌ�:�ބ�\�ֿ �ؙoM3�UD@2$��������O�����A��sEgɱ@�;�QQ�䃵�gF�R}6��.�t��S=y
�|ۋ�p�7Zk�bG`5F�!a��"�qE6�_���i��Y��W_�B���%�7o^{c{�jQ(�ng`uKa5쀞8}��:�Y�;���s?Oa�g2#[��;���ѣPD@<ZX�#;n2��&a1T|a�����uk�Ũ��q�Ju_(���OY�X}��T�zBI���˻Z���찄�6W���QY-��f���jVD�H haт���:��%3�Xd[0
EE�Q�,(�M�EcsLȊ��Š�%,2����'K$X(��p.�]�+�AX*���uQ��	HXHXts8Ҟ��хP��Ea��t(e��"�b���g�T$ a!a���(��U��EaQ��E��$uID v�[p��cq��X���W�(,�.g��ɱhxC�y�������E<���Ӭ�E ��E����s�U��$,r�Y	Wƛ�-��ծ�`�[�Q�6T���E@�& aQ7����JX�B��2�M/h]X��hۍ�����% aQ�T���#,��g���-�a��H��ָD�-m����Ȑ[��`�օ}PA�P�@�C�# a��I+(a�2���+?���."0����*�&z���N��n�;l��}�mw����w���W�?��Ͳ��x\&��mgJy(�DyZ���EPJ�3""
	������-�t�ziU�=�킶���k�M�zS���=���o��P�Z^fU&¢��i륬CL&Ǥ�52^��h������,�=돜Y}wDL1Τ-X�3�ޑ��΍�loW�AX��y���<��R�#��@M$,
�c�nV��;�]:nэ�hȎ���GFN�ɬ��AX�8���}�^�N�Rǂ����E��D�9;�2�w:]8��qs�sq���zx`���嵍�ټ�9��K�����G!�(͙?�^���8E������*��������D@%�����}��O>�ؕ�����\�k��ͭ��Z^<׹1��@iv�%ﱰ8�m�8���b�-	�a��i����D Y��	]Y�5hf',$Ŷ�����ei�!N:�O���v��^S�dG��-yaA��m�8���RA�&o7]Kr ����{�w�/,�?����M����z�"�^����h4�;���?n&�w�ԡ��
O�䅅�A��8�ة��[$‹���hx��r" ��]X�Z[9l��4��(:�����@rt�Z��2@'�Az��99�<��f=����� S�Y :����B~����Ԯ��(HXl	��#�����;1��aPX�.��{s��V��Jo��<�{�KXx�S�}��փL��6}]ܳ�mD<�CM��d@@¢.a�!8?��ͭ�;�A�YM�^A��jb�3]c}}}��n���>�DfjC'����	�����<�h�K����)a�&,���/x�^�Ry���'>�yv���;˗��1r;�;z���B8������@���j��hnO�G<��ާ�. I�^X���Q�BeaQ(�9��D�rS��U1��>�Cc
PX�Ǫ}������+�@���w�T���,��F*���
y����V���*j_D�^�Jz���c�=�d��k�񭥺�����Y�!LaQ���E���!�����y}����h��ͷ��oY��,Uaqvy�>‚��a
:F�&��dq���T�E@�  a�]���O���XՇ�W_�mZ����GڙQ�
ޑ}�`ѧ`�ŏ.\��{�e?TТ��QW�HXt��wZ�z��^
[���6�^��S�I
� �n��z��T�BR�
yAլV&�.*";	�`a���w6>�d�͍���i�;2}I
�b)��� !�B�
ZL�gt���D�O�$�E��z,�\AR_�l�O�_f" a1��NJOX���@u��B-��5h���E;�ùjz‚�.,���Kan���`f��E8��z"1����ju�9=aA���e��}��:IeӖ
Zdcj
T����5�F�u
,���Au��Ғ-�UA���Έ@$,�0��N&&,�|�M��!�B�i�<o��j�'�<4�("���o¡�������|mk��yf���%���"��<$u�dH@�"C�9%aQ\��W_�ݴ�_-�㧳E _���F��� ����w65�sf��7,�$�s���"�	��,><ޔ�Eq�$ۦ�n�Ư�����"�/	�|m����Dv��w}���]���O��o�#��P�����,HXda�	�L�c�6#��c1�3���j��N@¢u�܁d��[!Ɉ�x�e3�ty���E����4&�$"���wā_ aA�M�m���+O���y�U�"��@�$,4J�]��6�E���%,d`9����= �B�p\A��	K��tu�(HXDa&��LCX����n<V4aD‚n�����OM�@�$,R�j�1�!,��f,��%,�hS��*7���|	HX�k{y��*.����!' |��%,T�"���@P$,�2G�I@X����x8���q	&���F�
Z�p��"	��,Vw��r����xi/:a��^��D	HX$j���J@XDWp3:a�lr-��,=�t��@�$,r�zq̱�b�M>��0g��B-��Z��@@�"+�ه؅/<r6�܌��f�‚J!�{���{�"C�͛J���	HX�m��W����՜�QXp�PҔ5��pўd�?84~ؙ��E�#j������ছj�
�vc�7�{w?K�)��[��6HX�A=�kF-,�*���g�^
�'��Y��9" ����������fS�{��z��w��G>r`ߢ��M����  a�jLm�+,\E�X
n�4-v�+kp(�m��iO��!��>���f����$�E�͘���}%[�cw���1"�BD�^�򌯵x�7�-�:�MN;�I�$m]Kb$ a����s���jAR��Q'�5�����s�:��d% a����TXn�2w+6;~ۓ�|EJ�l���&����H^����х��$�P��N���kO���"	���奫�
����~�B��eZLkT{�M#��/�����6��Eq�
\�����=�X}����FtM�@	HXj�ƺ�� ��:
�A"}�EZһ8'�'Ycw�.$�����d5w8FaaɃ,	9t�`�8i.a'�I��d�ED >�٬�G',lNJ��;�!,ܞd����t:�NK�&"/	�xmWOϣ�%	���(�Iў���6jED`g�ώ脅�+ނ�i�˔�Ң��"����}FD',ȫ`��]w��Wr2�B{���E`	���E\‚�^��5ٴ"R�%#,�o{�!�"M��t
��"2	����D��n,�"�	@����`�t��W{�z�,jR�# a����q\‚�A���>�X��l-%a�^!TU�z�N��׵D 9Xy�#n�齿w��\J�+��"���;��s���E�Fi�K	�R2������래�Оd�ޱ��O@�"xy�`D���^fq��֍��3��'&,��ۓ,ޥ:�E 3�|d�	�Pƛb��s7[`�w{�-��oRm`P�����E����߱��d�1� ���>�I�5|�SĄY�{�:��jD2' a���f�t�G祥"����'>�y[�����H�fHX4�9ܫ���E!&~�%\����IFjm�{�dl=
]�$ aQ'�ۊBXX��S�)F��ž�l�6�E��p�*Q��]yG�-¥�wϊ�v�y���E�!d8�T�p��IX4d�`/��p%��v"�1W��ې-��EJ
�]��k��Hd�{z~���G�������~��7��E���n�/,\�M�X�gzm#WC��g�
の�̑@����en.�s�,��ö�����qφJ��*���	JX�8S�c_X�����TV`����`�i�L�SR�D`*�n?<<�y��YE'#T�Aa��?a?����i~�/�x�F�T�`31J	���M���^�4
n���X�������*�H����$���S�*�Z��P��������/�/������*�[��y�[�
�6�`\�E�� 
.�?�O�ﵐ����	C����
n&,,��<�x�� ��w8�d1܋�c��Y�h�}�?�}��x,xh���~V��nx��7)�?$P.Pµ��CaHXd=�|����L)0ma���?S4��x��5@��'LO� <�F'��B*Ԙ!2R�=Aǐ���1J"aQq
$wx����Li����K�ծ.�=-4��	 )�hP�����P�o>��ΆN�3���(M4!��c�!&�Na����Ij��y�D�\��"ɂ�in���9�7L�(),���;.
�$@��<;.�\��kQa�
�.��	�f ��K�ܐ�w���u����|�γ�� \��N	��%*��?��?#�ߙr�.���z�Y�`?�N�#s��v>t�l����R�.��L�G��(�>�؈�X�<�-��?�e�|L�����-U��.C&/,ଂ�L�4�QL����D����[��K��i[�����b8|��u>T%M�—��E4���� ?�?��q�ʂ2ȋ=.�)�.Z�ii�w��"da�j����VۍV-f�9u��ۼ�x�q���sk/��*�ѩ
~��p��[�����=��>G`@2�C|�����t�b�׶�y���4R'/�eP«Q)�C�Ÿ��h9XaQ,�ɝ�r��AX��E����v$`![{i��^�̧?Mk^x�9rĪY���vsQ��k_������c�~m��hmZ�J5�t��uK�$h�=��s��! ���2��$Eq,&/,�Ԃ5��իWK�W	����=,Xa�
n2�+�����QA�d���*%7��c����O<�w/<�W����[L݂�6�e���v� 2�;�siX)>֭T%��YrƐ?��e�h;�L���>K��s|�ظI"�ͤMOޑz�B'a���*[��߱K����E�����`���+��&G&�B-�{�c�� �,>��Z���
V3%a�����<��;*�G�K�H�&��a��N�؂�C��h�2�q�s|ݙ��D�Ω[JX�e�P�������d܉�������i������켆���dB|"72�x����A4���ϩ���m���j[�1K����M痿��-́���.$,B3b�	SX�d��zũ�id�^i*hQU��ȩ0����� р��n[�#H�p��-a�	��V�X��=E��B��t�	V&d�ձd��u1!�B�""�z�j��"ɂ�^�v�<�yC��E�Vj�w��|����6%��w��K�"��/�(&j����,eY؋<���	�Z�G�H�‚Z1�W䗈��*h�90����Q��=�&���"�Wu��g	�.�_�d��$,b�l�}PXW*�Tp�N���+�U�"s5�STI�>�I$D?��Kh����6�-9��ۜLV�X\�"����`�_B������TA�4�X�(LU؝�	���j��A��g�]�å�HXx%A�
7��$E@P]�F�x���c(��i�/K��*Xk�Sh�]��^X��J%�g_�S"Y�ǵ�E�tcn,4a�ԤK�^#1;f����T"�"R�؆���wʐ��!���ۯ�RL���b�)���(���Ia�ݾmb�vqL�:{jx$R��| ��H��n�0ü��E�vi�W�	v�wtLn����+�'l�̚�~��Rk������:�E�����E�f�0���E�V�>m+X1�C]A�)G/xs�� ��<p�HLJ h&��v�m[���%,�x�h�LJzMmB�V�]�Iھ�۹>�
,0��"��CW�O@��?㰯��Ȥt������
Ha?���lq)��w/�P�a����"(aAgl���6�ǂ�q����Zm�o��l�a	���-�>Վ����‚,WD�I�n���k����~X+h�Rb/wn�՛2�\�	GX���H>��ǂij-T�d�;6“��qSaw~���WEh�j]� ,P�J,�������
��D�S�#�����|��n/8���)$�-g�|(e�W3��G�#,P�Ԯ@X��a�� [a�7�9�Q�Zd8��G8'(����]��%l�a��z9]X�'f�ԣL:0E�nT��	��;�ۑL8� &;������|VN��L<��p�s̒�Ҏ�`�l��+h��Ԫ��u8���hj�oK���tL=�G`���N�N�<�P@
�x,؍���$x�&��v�/�|��t�ml�+ĴŐ��)��P\�F�<���M�C֟�'����_ex�u�ZA��E��I�
Z蛡�)�օxh+��-�-^w���E~��x�x����kM��r&J>���do9(�?�Y'ALv &P-���!2��xM�:�_��J^�E�Q\:a�Ւ����
ZD�X����jsr,�v֮�j$L�C!L�������:�YG.pT���_<H
�ϙc��_P��_z�s�S��4X�
DX���9�YXp���_y�D��Y
�Co7�j�<�����tL=�M`���݃	��/Aj�tQ�%xM\���%��0�!9<��B�8H����4+��lweg�h��p6KA&`�JCZXG‡���(���e�0��D��/*ռ��98a�ۛ&saQ,h����zK&p��h}i֜a�����d��nU<���s
�_�d��{Q~*� ,���81����#UТ^����BB�� �.��?�	L�Z��`s<V'��<�|O��'�
�^��=���r���1J�Ǹ��7�ɏ7���G�
A�2��`�n0x�H�d��
�&���b��n]X��j�PA�T��e	U۲>�z�j���JDX� ���X���.ĝ<Z�g�g=H�O���VA�$'EH���˧���I��̠�6`q���� �G�����4������c����1*h��)�@x�r;�������陸���ʐ#)�F;��c�D�‚T���V�%��dSA�dLi�=Al���J̸U����p�ޚ���� �7���M�v���Ax�L�����PzM�,��]ܞ X6��i,U	�,,`���5#�.�����8FS_�z�*���oQX�8vQ$�9��Њ-�*�z���<c)�K�dA���O\X ^ZLz�\�`��b�٥�B����A>��$�4�S�Q��EUb�� ��6^ػ�[_nڨ�.e!,`ʷ:�z�.��:��ՐiQX�0"� 
��\��������إRO�B`
�mM���+�K��\��CF0�ɴ��N���>����Q�!��ȁ���e�\A��3�x�٨WA��L)�Z�@��'#aa|Y«��"��b�Ejw��>���%,�O�z֧�&�/h���DOp'�J�r��?��p7������n~�i��^!s��5���fK��Y[�%,\p��!s4��%,�&s-�%��D\�{��|$��.�Ϋ���(,�ɇ�E�"����-����[nEX��`nϣ�HX�n:�nB�YԷ"cY�e��m��p2��X��w��ۦ-Hf��
�V��K��}��TC�`�b�A�s>D�B*na��Y�����|���EL�*����hEXPd� z�OU�S<��%,����.	�H|��)�3�;�%�Ǯz7�s}V'#������y�ua�-�����Z�P�9/Q��{��p!ۓ��Jᜁ^ç��eI��´a�\N¢k�?�!!�<�E�7R�)(��x���A$,�>�{�ɯ�����v��<�
7P�ݓ��2��<�E�¢�m�
�J
��R8)���V�eɋ�y��%Ye{��E��yj���NT�h+gM����U
g�!��I�E���0V[��� ���hXX��޷gNT��m	g	���;�™��l�MP򺖳i	R�K���r#�]�ͩvڂ�$֠&_K�aaQ,��m�_	��nC��
���T+X�&�*D4�bޭtC
�����;f�V;+mw_�‚ˡ�xy|�¿=<�P�b'����i���,�g�fc�{��Z�T#I��oV�o��r&�-��a%�%�'�
J�y������.au6m�1�XR���s��Ŏ�vڂ�;*U�_����f�U��#��H�)��f�T���l
m�QɎ�z��G}		�I�s5�q�#ғ܄�Iaᶄ`���ou��b
���q�Բ퍎�'�WB����N��@��j�Ƅ������o�y�i�e�'l'n^fr��!�,���Fϳ��o‰�/a1Š�k�Ƅ.n�2EX����'�GC�����4(ӦŞ��(.1������TSu�Au~d{b1�Ƅ���<�*���t�:"o�ۙ*�nS��y�a�-�>	�1M�=��(e���XL��{27X3��8*���Bߠ��\����n7g)��Ź�!���ж -"�KKX��J_�9��>���sڢa��R{O��Nu}Mٙ��J�ō�-�����x��.��mE;/p�nT¢�yM[�3m�/|1�;�aA,	n�lW�m�J�VK$�3
�I���%��Y-�k��jV��/c�
���c�2�Ty��]�g�R8qjڔ!V�1ZbZ/ϬZ���l�ĴE‚9�6-^��j�o9�|-mP~����:RKL�"�a;�=%mр����x=p��<�L��s�(������&\V�$�&�.�M�N�Z3�4mр�p��0fĝ�i%�iA4۵����g�	��Զ��.���̰	�ٍ����-,����f��E����A[��wa����6ϑl▘j�yHf{���\�O@[����>�x�M5	��wb�*�0��+�m�#���b�ɴ���3?Q�b�	0�-�Z�[X}�1�P��i�1	��n6[�����U=�/�Ĕ�XUO��"	�������v�Wa�%��6�d�XT�눠�g�DNm�]	]Ճ�aI�@��8|�R����F@¢�����*,��m_?�x�8�$,*�u朷���쮄���1Fȉvσʈ�JO�;��Y�d��.�Wa�O!�����<w�^{͕�W)�yHN8�6�%���
\z��I�u:�\N�¶{��;UN����Nc.ᢷw�-�Cr¹n�)�E-��9�f%,j6��u7�OX��F*�9d4�Bf�����
Z^4����]LY�ʷ^�z��	$,�Em�;5�u‚/K�&PX��,�)O������l�~��v1%j)��u�KXx�3�D�O�R>�x����OX:x�j&j�k/�,�F��[}���j���EaU�X}�%�5�Ͷ)	_�'��P%oV���lƙ'a��rM�����vs"�;ϕXК��,o%���&�V؜ۑ��h}��B�cYl
;O�½�qU�8!��|,��`Z�0��.g���~��5X��	���1��xy�5�IX�������X��D���VhA[��b�b��_�9SK�jD$,������<k�,~`"�aa�R��@���w�eֺ�����B���Yc�j*gޭO ����3^��2C�
�8T�Y
f���#�r"P�:D��y,��lr���`>�un+$,��n���"#����G.��ZKך�^�]�j��DN-a���T�`�܊Tȝ��(�$,�A�i�mT�aA�	ŏX
M��.C�M0�;���+A@2a)i�:��a�Y;�&d
�
�d\��X�/�?�ڟ6t�i��]XX�e�W�u1��"P��
ˉ&o)��b�qI�p��I۰@�ה�h��q�J�b��T�]X੶��#�굱�K%���,;�֝�����N�@-�e��=7�73^	�f8o]�rڭ"'�v��jT�&�c{:4
7��IX�o+b���t�h2���A��30�)S	HXLET�xn�s!����U�:c$,�"�z���T5㧲*@����2m6V	�.O@¢<�ڎ�DNW���E"�
\2����V���lVkC��Ւ��[�e�B��'BH�{-�K��L@�bfts�H�;s䶾H�^aAsKP�Y߮`��<�O����S��}|�Aj��b��2�t�l$,f�6�YC�DZ��]��`}�U�fI��=_¢.�Z�,ޔ|��X�d��z7:gO]&P;"0J@¢�Y�=;��X�S���j�5
��pxr�5���Y��UhM:�%HTy�Л��R���*[W��S;;��hsn�-�ɭ�7Y���M���-4e,�6�`J	��9�1+�����]�SSS	���TD~�j��x2���H�‚��8`��>�~
Y�u	�*���D�,U���	D$U�zw��NMM& a�a�+ڏ�h��n]���h��@a��5�HX�h+̀ӂۇآ�[U�q����$,J��{�[��[��c��)��A��Q;�N�+SU:��D��,WI�t�[�β�P��J�J�C@�bzu���!���G�V4��U��(�l��u���$,��|C��o��E�V�Wջ�ojm*	���:��#��m��&w)�EXXι�ݠ8HC3F�)�ia�����G
��V��j�W�^Ք�fHX4ù�U��&w)�EX��&YBL��hu��G��VSRN��*3�NR���|��VK"0���EXS��]�jnɟ��šO9������Kݖ����T���n���*aѾ
�z`Pۥl~a������=8��P\<�W)J7�Dj�Z\'��w�q4J	������.e����<���!N���TtZ�i��@OX&8Y�M��e-`���Eb��وܟ'sNaQ�Jq�@'S6�*:-�ʹ���i�k׳�h�r,��K�Ō���]��t��Λ/��a�k��@���dn�U��Z�q�WH���J
���-�V*�<�rW�;�r�Y�N֔���J4�i�5V	���1ԛ��M)�W{wgC���q��4jp6�:-얼��;� �N�r6�:K�$ a1'@�۲1{X�-j�zfaQ,\{��c��%���մ�j�3���ޭ[2�	��$,"0��մE�K:gx\]�`>�2_�Wu��wUbU�w�8�=$�<�b�nݒU'������E�<}��"Ի���¾��(*\��ՙU;�
q��m`i��X�zw�颣�& aQ7Qo�.�<�
g�U[�����*�v���Gڇ7��4,aр%pTXAkU%P��f�.Q���EyV��
g�跨*,�=��<R�lsB�b6n�βEU����J0�z��`ҰX�mջ�`��H}�S�>HX����!m�w�ws^����V�[؍ׄG'j%�l�%,f�V�,�z�e�ˡ���	[���U�:It�>��m��-����-/,�9���y��^�����՛G'���E|�%��N7V�	T�;����kPK
T��U�Q�a�NKX�J��y���B^��X���O@*Y�ب<�a�*��IX�j﮶X��Ŵ[
Ͷ泌�0_�@p���'�ˋ/�J-�~KX4i��m�Or�Rڙ̭�-LSZ��C��A@��Ն��Q�ma��|�͐�0YX��**��۵�!j\F¢I#�"��))�6����G+�� H�3JךJ@�b*���n^{��v���	�G+b��N�����	b㝓�h9�1��2�4�8	��Qa+A������M& a��ϓ�
K� >�ʷ^)��+,8�g1�[�6��E�sf�F��HX�DzTK�g��I�E]5`J]��A�=A�V�x`�&�" a1�@N&B�¹�[�� PRF^�
��5��pT Yh-�gq ��nHX4oW��L��?�	|��
u|E4SWy,����R,yz���>`5�dyQW�\����7��i�+�y�E���d	nۼ�"��%m��*ԕ0�i��<-@�wI"��l��N��4H��_z���N$�����5xl�I��B^V�R�
�Z���M��pw�C�2��
�
]�	T�l��'�4h�����Aa�$BC�ᗿ���'Ia#�/|ù�I���j�HJ�CյE�"{1[�V�̰����<�R+��}�~(�][�$���" a��f�C���9!x��0Ld��(�����O��#)�h�\�Zsp��f7h�aG���Uc��[�K��1�Ruՙ�zF1�/��[������P�	W2+��NVlU�w~����b��WHdFYLh�Cd�)��!���	œ����J��u�F6n	����O���|�
d=����o/�	���ފ��C�\`�H��[�bk������Bj%ZњN��e�\:d���*��|�uv�$,�5�,%�b��3L�P¦�j2mԍ�$,�"�"P3	����ќe0l%r�~�-r�h��S)�o6�[�Y u[m%A@�"	3N��K�����9���G���xm�����,������(a��/i��dGR�_BX$�D��RP&Sg' a����ލ�����_�^�[�n��' 6�/�����qy�1L@�"�9A�z֝�z��_�%�-�i��"4\�L& a���<Gά�;$-n��' z��ƭ��1B	�6�O��%4��-�P0����2����4��*oNE��7:�v���K�/
Dnm���0F@��ʚt��KX��:o��k�21Ua[���ϼC�"�	�6�7z�߬_|va�\�s��#���k+O����Z�h��]L�"Xc��z[~�*��*X���`����F@�"4��ޟ�J8~q}���3���Zy���E޻|��8���<,�E��nP���yf�߂�y-q>W!���HU��C�& a�y��\W=,-wnt���KK��9��A��X-r|������"utDmHXD2����D�2��vٚ�bf�H��n�O@¢}��Ђ��w	�,��vs�vw�ȡӫ�
w��w�5�hy,<­�i�-X�j��}��I�d��O�	^/T5#�HX���A#J77��CDntW�<y~m;0��=e��#�V�%,²��AL�yp�	���!��ڗ�?�	��;AB!���@�d�$,�5M=�-R	�7�.<e�D�ִ��Z���ƫ���!a�����^�l\�zu��� ށ#�B�hZ�0�CS"	����NJ?X[y��zc�ȍ��Zk�����*�}����=wߍ���;���ʷ^��uA<�o�����Ri�:Xj' aQ;Ҡ�iA���7�>l�����<u�߃�:#������>Oa	b"�je��^�*/�(�NFz����hn$��4B@¢̭]�����݀ȉ��"�uO�^E�Z�ua��J\�:(�Ł}�8H���08���g�EU��9*�,A
S��ZHXԂQ����O�]<���:O
W�7�;�������U�~�?�~�$n	�1Ia����f�c�o�0H�+$H��S" � ��������4L20�n�C���=��?�?��@dxZ�*-�+G9Z]c��>��_z��#FCະ%C?8*�>fK˘��:]Z! a�
v]TD �F&q�����>s���_��^}�ʕ+>�k%BP�H���Er&ՀD@Z%@J&j��.��"�&	�6���" " "�	���ሀ���@�$,ڤ�k�I@%��F-������f@$,2��""P7���Ew��nb��'�f9��{�O�?^��q��7��Ӌ���܅�7��hO���ƕ��0?r��W����>:q\�;��sxe����/��Ү�N��/7>�J�l�V_���O�{�����>n�z���-&�}|�HX4�\h�@ҕ7NgTU9�����(�o�),��������k;^��;Io�Kϯ^o�E��1Gά����.a��SD@|���DV��`ot����n������xPl�x����{>����y" ���d�!aQ�U�z,���Yk�4����Zy�f�3�;��=[/�r�ⵆ���Ng��M 7a����\�띋g-����յ^h��z�Ҳ��?�|��~�o��t7S��..o}��:~���C��E4F������nt/JS�c/���m�>�611�1^X���Ƶtj�Q�]`5f�=B��t�H�{ǖ/��� �qw��K�-���K�)1�����X[u���?�
&�l�_<a]m|�x	������|r�'�~{;�o�=��޸�F�ո�*�ҵmm��^:���J6,�F�~���*#,6o�^n�3�Ϯ^�|~�Ÿq=s~��k�'ٳ�:\:�Ƶ��B���Q�ɹ�Ee62Yw~�o��R�?X[yf(qu8걣���*q��E	H:DD V�
����/��K˝-e��j��US��Ua/�g;�w�U��b����ݽ�k���,p@o
�'�7:�L�t�@����Z�X�RN�����:"q�J돥��X¢κ��@+2��cz�kۭ��Lw��(�ռ��օm?�{EM��^~~k��BġP��|�ԅq����C!���j/~qc}��v���J��]�}-�&|�?�u'r�]�}���.�b4�S�-ukm��VDf‚R�j:�B¢���.*"��
¢���p��&����Խ������v�Z����kս���|x}�%���h�",�!�����%�HA�;�cp�w4�``ֺU����3��R}��X���a+Ud�;�Kڙ������x&�[����5vx��7눰��󅿽f��b�?����b�o�&��V�mҹuO�_�/�p��-S�C�
;
��K��R�9��n9��������IWm���L Wa1X�`�3�/.L�X�*,��$��:w�va.���%$�����?�BλK�,,f���.0�ݱ1ڢ-a��M�ˋ���O�
�A�|Ua�Pc(d�Z�=�����p��Y*M���f��{���Qȇݾ�$,|>[Զ�@�$,���,,�m���b�c��MW�a�ZF7y�����]\X�&��z�py���l��.2���˹��!�Tkɛ�>l4l�<HX�(,�z�[]L[º	WUz�rJW�:taq{��Wkt,�<��(F�C�nȲ�6�z����/z+\������r�<�-��@�$,���j.���F�%���#�/�۸Y�i�m��,��n�v.���w;�sc	�#,
�|�TGr,�+����F�ȃ���,�b��w�"��5S=[GRx�+aO)����jLm��*�c�R%���X�w~�]H�X���T�%��x�h�" �HZX�nӡ���c��%@����#%V�6�#]ED@�  aQŌUh�=֕-�U�����B�۫�r'u����H@¢��$,��*}l�i1���t���S���8," �	HXLg�?B¢
�
Ǻ��lVr�-۩��?��;�7��ZO�W'Ԯ��$K@�"Y�j`" " "�<	���" " "�,	�dM�������@�$,�g�+�����@�$,�5�&" " ���h���(" " ���Hִ�����4O@¢y溢����$K@�"Y�j`" " "�<	���" " "�,	�dM�������@�$,�g�+�����@�$,�5�&" " ���h���(" " ���Hִ�����4O@¢y溢����$K@�"Y�j`" " "�<	���" " "�,	�dM�������@�$,�g�+�����@�$,�5�&" " ���h���(" " ���Hִ�����4O@¢y溢����$K@�"Y�j`" " "�<��չ�DR�CIEND�B`��D<EndNote><Cite><Author>Harrison</Author><Year>2011</Year><RecNum>1599</RecNum><DisplayText><style face="superscript" font="Times New Roman">21, 25</style></DisplayText><record><rec-number>1599</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">1599</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Harrison, W. W.</author><author>Bearse, M. A., Jr.</author><author>Schneck, M. E.</author><author>Wolff, B. E.</author><author>Jewell, N. P.</author><author>Barez, S.</author><author>Mick, A. B.</author><author>Dolan, B. J.</author><author>Adams, A. J.</author></authors></contributors><auth-address>School of Optometry, Group in Vision Science, University of California Berkeley, Berkeley, California, USA. wharri@midwestern.edu</auth-address><titles><title>Prediction, by retinal location, of the onset of diabetic edema in patients with nonproliferative diabetic retinopathy</title><secondary-title>Invest Ophthalmol Vis Sci</secondary-title><alt-title>Investigative ophthalmology &amp; visual science</alt-title></titles><periodical><full-title>Invest Ophthalmol Vis Sci</full-title></periodical><alt-periodical><full-title>Investigative Ophthalmology &amp; Visual Science</full-title></alt-periodical><pages>6825-31</pages><volume>52</volume><number>9</number><edition>2011/07/12</edition><keywords><keyword>Adult</keyword><keyword>Age of Onset</keyword><keyword>Aged</keyword><keyword>Diabetes Mellitus, Type 2/blood/*complications/epidemiology</keyword><keyword>Diabetic Retinopathy/*complications/diagnosis/epidemiology</keyword><keyword>Diagnosis, Differential</keyword><keyword>Disease Progression</keyword><keyword>Electroretinography</keyword><keyword>Female</keyword><keyword>Fluorescein Angiography</keyword><keyword>Follow-Up Studies</keyword><keyword>Fundus Oculi</keyword><keyword>Hemoglobin A, Glycosylated/metabolism</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Papilledema/diagnosis/*epidemiology/etiology</keyword><keyword>Predictive Value of Tests</keyword><keyword>Retina/*pathology/physiopathology</keyword><keyword>Risk Assessment/*methods</keyword><keyword>Risk Factors</keyword><keyword>Tomography, Optical Coherence</keyword><keyword>United States/epidemiology</keyword><keyword>Young Adult</keyword></keywords><dates><year>2011</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>1552-5783 (Electronic)&#xD;0146-0404 (Linking)</isbn><accession-num>21743017</accession-num><work-type>Comparative Study&#xD;Research Support, N.I.H., Extramural</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/21743017</url></related-urls></urls><custom2>3176012</custom2><electronic-resource-num>10.1167/iovs.11-7533</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Bearse</Author><Year>2006</Year><RecNum>1625</RecNum><record><rec-number>1625</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">1625</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bearse, M. A., Jr.</author><author>Adams, A. J.</author><author>Han, Y.</author><author>Schneck, M. E.</author><author>Ng, J.</author><author>Bronson-Castain, K.</author><author>Barez, S.</author></authors></contributors><auth-address>School of Optometry and Vision Science Program, University of California, Berkeley, Berkeley, CA 94720-2020, USA.</auth-address><titles><title>A multifocal electroretinogram model predicting the development of diabetic retinopathy</title><secondary-title>Prog Retin Eye Res</secondary-title><alt-title>Progress in retinal and eye research</alt-title></titles><periodical><full-title>Prog Retin Eye Res</full-title></periodical><alt-periodical><full-title>Progress in Retinal and Eye Research</full-title><abbr-1>Prog Retin Eye Res</abbr-1></alt-periodical><pages>425-48</pages><volume>25</volume><number>5</number><edition>2006/09/05</edition><keywords><keyword>Diabetic Retinopathy/*diagnosis/physiopathology</keyword><keyword>Electroretinography/methods</keyword><keyword>Humans</keyword><keyword>Prognosis</keyword><keyword>Retina/*physiopathology</keyword></keywords><dates><year>2006</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>1350-9462 (Print)&#xD;1350-9462 (Linking)</isbn><accession-num>16949855</accession-num><work-type>Research Support, N.I.H., Extramural&#xD;Review</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/16949855</url></related-urls></urls><custom2>2773701</custom2><electronic-resource-num>10.1016/j.preteyeres.2006.07.001</electronic-resource-num><language>eng</language></record></Cite></EndNote>uD���y������K�
_ENREF_21uD���y������K�
_ENREF_25�*D<EndNote><Cite><Author>Harrison</Author><Year>2011</Year><RecNum>1599</RecNum><DisplayText><style face="superscript" font="Times New Roman">21, 25-28</style></DisplayText><record><rec-number>1599</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">1599</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Harrison, W. W.</author><author>Bearse, M. A., Jr.</author><author>Schneck, M. E.</author><author>Wolff, B. E.</author><author>Jewell, N. P.</author><author>Barez, S.</author><author>Mick, A. B.</author><author>Dolan, B. J.</author><author>Adams, A. J.</author></authors></contributors><auth-address>School of Optometry, Group in Vision Science, University of California Berkeley, Berkeley, California, USA. wharri@midwestern.edu</auth-address><titles><title>Prediction, by retinal location, of the onset of diabetic edema in patients with nonproliferative diabetic retinopathy</title><secondary-title>Invest Ophthalmol Vis Sci</secondary-title><alt-title>Investigative ophthalmology &amp; visual science</alt-title></titles><periodical><full-title>Invest Ophthalmol Vis Sci</full-title></periodical><alt-periodical><full-title>Investigative Ophthalmology &amp; Visual Science</full-title></alt-periodical><pages>6825-31</pages><volume>52</volume><number>9</number><edition>2011/07/12</edition><keywords><keyword>Adult</keyword><keyword>Age of Onset</keyword><keyword>Aged</keyword><keyword>Diabetes Mellitus, Type 2/blood/*complications/epidemiology</keyword><keyword>Diabetic Retinopathy/*complications/diagnosis/epidemiology</keyword><keyword>Diagnosis, Differential</keyword><keyword>Disease Progression</keyword><keyword>Electroretinography</keyword><keyword>Female</keyword><keyword>Fluorescein Angiography</keyword><keyword>Follow-Up Studies</keyword><keyword>Fundus Oculi</keyword><keyword>Hemoglobin A, Glycosylated/metabolism</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Papilledema/diagnosis/*epidemiology/etiology</keyword><keyword>Predictive Value of Tests</keyword><keyword>Retina/*pathology/physiopathology</keyword><keyword>Risk Assessment/*methods</keyword><keyword>Risk Factors</keyword><keyword>Tomography, Optical Coherence</keyword><keyword>United States/epidemiology</keyword><keyword>Young Adult</keyword></keywords><dates><year>2011</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>1552-5783 (Electronic)&#xD;0146-0404 (Linking)</isbn><accession-num>21743017</accession-num><work-type>Comparative Study&#xD;Research Support, N.I.H., Extramural</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/21743017</url></related-urls></urls><custom2>3176012</custom2><electronic-resource-num>10.1167/iovs.11-7533</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Bearse</Author><Year>2006</Year><RecNum>1625</RecNum><record><rec-number>1625</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">1625</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bearse, M. A., Jr.</author><author>Adams, A. J.</author><author>Han, Y.</author><author>Schneck, M. E.</author><author>Ng, J.</author><author>Bronson-Castain, K.</author><author>Barez, S.</author></authors></contributors><auth-address>School of Optometry and Vision Science Program, University of California, Berkeley, Berkeley, CA 94720-2020, USA.</auth-address><titles><title>A multifocal electroretinogram model predicting the development of diabetic retinopathy</title><secondary-title>Prog Retin Eye Res</secondary-title><alt-title>Progress in retinal and eye research</alt-title></titles><periodical><full-title>Prog Retin Eye Res</full-title></periodical><alt-periodical><full-title>Progress in Retinal and Eye Research</full-title><abbr-1>Prog Retin Eye Res</abbr-1></alt-periodical><pages>425-48</pages><volume>25</volume><number>5</number><edition>2006/09/05</edition><keywords><keyword>Diabetic Retinopathy/*diagnosis/physiopathology</keyword><keyword>Electroretinography/methods</keyword><keyword>Humans</keyword><keyword>Prognosis</keyword><keyword>Retina/*physiopathology</keyword></keywords><dates><year>2006</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>1350-9462 (Print)&#xD;1350-9462 (Linking)</isbn><accession-num>16949855</accession-num><work-type>Research Support, N.I.H., Extramural&#xD;Review</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/16949855</url></related-urls></urls><custom2>2773701</custom2><electronic-resource-num>10.1016/j.preteyeres.2006.07.001</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Harrison</Author><Year>2011</Year><RecNum>1600</RecNum><record><rec-number>1600</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">1600</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Harrison, W. W.</author><author>Bearse, M. A., Jr.</author><author>Ng, J. S.</author><author>Jewell, N. P.</author><author>Barez, S.</author><author>Burger, D.</author><author>Schneck, M. E.</author><author>Adams, A. J.</author></authors></contributors><auth-address>School of Optometry, Group in Vision Science, University of California at Berkeley, Berkeley, California 94720-2020, USA. wwh@berkeley.edu</auth-address><titles><title>Multifocal electroretinograms predict onset of diabetic retinopathy in adult patients with diabetes</title><secondary-title>Invest Ophthalmol Vis Sci</secondary-title><alt-title>Investigative ophthalmology &amp; visual science</alt-title></titles><periodical><full-title>Invest Ophthalmol Vis Sci</full-title></periodical><alt-periodical><full-title>Investigative Ophthalmology &amp; Visual Science</full-title></alt-periodical><pages>772-7</pages><volume>52</volume><number>2</number><edition>2010/10/12</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Blood Glucose/analysis</keyword><keyword>Diabetes Mellitus, Type 1/complications</keyword><keyword>Diabetes Mellitus, Type 2/complications</keyword><keyword>Diabetic Retinopathy/*diagnosis/etiology/physiopathology</keyword><keyword>*Electroretinography</keyword><keyword>Female</keyword><keyword>Hemoglobin A, Glycosylated</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Models, Statistical</keyword><keyword>Predictive Value of Tests</keyword><keyword>ROC Curve</keyword><keyword>Retina/*physiopathology</keyword><keyword>Risk Factors</keyword><keyword>Sensitivity and Specificity</keyword><keyword>Young Adult</keyword></keywords><dates><year>2011</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1552-5783 (Electronic)&#xD;0146-0404 (Linking)</isbn><accession-num>20926810</accession-num><work-type>Research Support, N.I.H., Extramural&#xD;Validation Studies</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/20926810</url></related-urls></urls><custom2>3053106</custom2><electronic-resource-num>10.1167/iovs.10-5931</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Wright</Author><Year>2012</Year><RecNum>1582</RecNum><record><rec-number>1582</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">1582</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wright, T.</author><author>Cortese, F.</author><author>Nilsson, J.</author><author>Westall, C.</author></authors></contributors><auth-address>Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Goteborg, Sweden. tom@maladmin.com</auth-address><titles><title>Analysis of multifocal electroretinograms from a population with type 1 diabetes using partial least squares reveals spatial and temporal distribution of changes to retinal function</title><secondary-title>Doc Ophthalmol</secondary-title><alt-title>Documenta ophthalmologica. Advances in ophthalmology</alt-title></titles><periodical><full-title>Doc Ophthalmol</full-title></periodical><pages>31-42</pages><volume>125</volume><number>1</number><edition>2012/05/23</edition><keywords><keyword>Adolescent</keyword><keyword>Diabetes Mellitus, Type 1/*physiopathology</keyword><keyword>Diabetic Retinopathy/*physiopathology</keyword><keyword>*Electroretinography</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Light</keyword><keyword>Male</keyword><keyword>Photic Stimulation</keyword><keyword>Retina/*physiopathology</keyword></keywords><dates><year>2012</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>1573-2622 (Electronic)&#xD;0012-4486 (Linking)</isbn><accession-num>22610144</accession-num><work-type>Research Support, Non-U.S. Gov&apos;t</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/22610144</url></related-urls></urls><electronic-resource-num>10.1007/s10633-012-9330-5</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Xu</Author><Year>2006</Year><RecNum>1329</RecNum><record><rec-number>1329</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">1329</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Xu, J.</author><author>Hu, G.</author><author>Huang, T.</author><author>Huang, H.</author><author>Chen, B.</author></authors></contributors><auth-address>Department of Biomedical Engineering, Tsinghua University, Beijing, 100084, China. xujin@ustc.edu</auth-address><titles><title>Using multifocal ERG responses to discriminate diabetic retinopathy</title><secondary-title>Doc Ophthalmol</secondary-title><alt-title>Documenta ophthalmologica</alt-title></titles><periodical><full-title>Doc Ophthalmol</full-title></periodical><alt-periodical><full-title>Documenta Ophthalmologica</full-title></alt-periodical><pages>201-7</pages><volume>112</volume><number>3</number><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Diabetic Retinopathy/*diagnosis/physiopathology</keyword><keyword>Diagnosis, Differential</keyword><keyword>Electroretinography/methods</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Models, Theoretical</keyword><keyword>Retina/*physiopathology</keyword><keyword>Severity of Illness Index</keyword></keywords><dates><year>2006</year><pub-dates><date>May</date></pub-dates></dates><isbn>0012-4486 (Print)</isbn><accession-num>16779498</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16779498 </url></related-urls></urls><language>eng</language></record></Cite></EndNote>uD���y������K�
_ENREF_21uD���y������K�
_ENREF_25uD���y������K�
_ENREF_294D<EndNote><Cite><Author>Lung</Author><Year>2012</Year><RecNum>1577</RecNum><DisplayText><style face="superscript" font="Times New Roman">29-31</style></DisplayText><record><rec-number>1577</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">1577</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lung, J. C.</author><author>Swann, P. G.</author><author>Wong, D. S.</author><author>Chan, H. H.</author></authors></contributors><auth-address>Laboratory of Experimental Optometry Neuroscience, School of Optometry, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China.</auth-address><titles><title>Global flash multifocal electroretinogram: early detection of local functional changes and its correlations with optical coherence tomography and visual field tests in diabetic eyes</title><secondary-title>Doc Ophthalmol</secondary-title><alt-title>Documenta ophthalmologica. Advances in ophthalmology</alt-title></titles><periodical><full-title>Doc Ophthalmol</full-title></periodical><pages>123-35</pages><volume>125</volume><number>2</number><edition>2012/07/26</edition><dates><year>2012</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>1573-2622 (Electronic)&#xD;0012-4486 (Linking)</isbn><accession-num>22828871</accession-num><work-type>Research Support, Non-U.S. Gov&apos;t</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/22828871</url></related-urls></urls><electronic-resource-num>10.1007/s10633-012-9343-0</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Chan</Author><Year>2011</Year><RecNum>1602</RecNum><record><rec-number>1602</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">1602</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Chan, H. H.</author><author>Chu, P. H.</author><author>Lung, J. C.</author><author>Ho, W. C.</author><author>Ting, P. W.</author><author>Sum, R. W.</author><author>Ng, Y. F.</author></authors></contributors><auth-address>School of Optometry, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, PR China. henryhl.chan@polyu.edu.hk</auth-address><titles><title>Detection of early functional changes in diabetic retina using slow double-stimulation mfERG paradigm</title><secondary-title>Br J Ophthalmol</secondary-title><alt-title>The British journal of ophthalmology</alt-title></titles><periodical><full-title>Br J Ophthalmol</full-title></periodical><alt-periodical><full-title>Br J Ophthalmol</full-title><abbr-1>The British journal of ophthalmology</abbr-1></alt-periodical><pages>1560-3</pages><volume>95</volume><number>11</number><edition>2011/02/15</edition><keywords><keyword>Adult</keyword><keyword>Case-Control Studies</keyword><keyword>Diabetes Mellitus, Type 2/*complications</keyword><keyword>Diabetic Retinopathy/*diagnosis/etiology</keyword><keyword>Early Diagnosis</keyword><keyword>Electroretinography/*methods</keyword><keyword>Humans</keyword><keyword>Middle Aged</keyword><keyword>Photic Stimulation/methods</keyword><keyword>Sensitivity and Specificity</keyword><keyword>Signal Processing, Computer-Assisted</keyword></keywords><dates><year>2011</year><pub-dates><date>Nov</date></pub-dates></dates><isbn>1468-2079 (Electronic)&#xD;0007-1161 (Linking)</isbn><accession-num>21317214</accession-num><work-type>Evaluation Studies&#xD;Research Support, Non-U.S. Gov&apos;t</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/21317214</url></related-urls></urls><electronic-resource-num>10.1136/bjo.2010.192476</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Bronson-Castain</Author><Year>2007</Year><RecNum>173</RecNum><record><rec-number>173</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">173</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bronson-Castain, K. W.</author><author>Bearse, M. A., Jr.</author><author>Han, Y.</author><author>Schneck, M. E.</author><author>Barez, S.</author><author>Adams, A. J.</author></authors></contributors><auth-address>Vision Science Program, School of Optometry, University of California at Berkeley, Berkeley, CA 94720-2020, USA. kbc@berkeley.edu</auth-address><titles><title>Association between multifocal ERG implicit time delays and adaptation in patients with diabetes</title><secondary-title>Invest Ophthalmol Vis Sci</secondary-title><alt-title>Investigative ophthalmology &amp; visual science</alt-title></titles><periodical><full-title>Invest Ophthalmol Vis Sci</full-title></periodical><alt-periodical><full-title>Investigative Ophthalmology &amp; Visual Science</full-title></alt-periodical><pages>5250-6</pages><volume>48</volume><number>11</number><keywords><keyword>Adult</keyword><keyword>Diabetes Mellitus, Type 1/complications</keyword><keyword>Diabetes Mellitus, Type 2/complications</keyword><keyword>Diabetic Retinopathy/etiology/*physiopathology</keyword><keyword>*Electroretinography</keyword><keyword>Humans</keyword><keyword>Middle Aged</keyword><keyword>Retina/*physiopathology</keyword><keyword>Time Factors</keyword></keywords><dates><year>2007</year><pub-dates><date>Nov</date></pub-dates></dates><isbn>0146-0404 (Print)</isbn><accession-num>17962480</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=17962480 </url></related-urls></urls><language>eng</language></record></Cite></EndNote>uD���y������K�
_ENREF_32\D<EndNote><Cite><Author>Ng</Author><Year>2008</Year><RecNum>1402</RecNum><DisplayText><style face="superscript" font="Times New Roman">32</style></DisplayText><record><rec-number>1402</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">1402</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ng, J. S.</author><author>Bearse, M. A., Jr.</author><author>Schneck, M. E.</author><author>Barez, S.</author><author>Adams, A. J.</author></authors></contributors><auth-address>Vision Science Program, School of Optometry, University of California at Berkeley, Berkeley, California 94720-2020, USA. jsnng@berkeley.edu</auth-address><titles><title>Local diabetic retinopathy prediction by multifocal ERG delays over 3 years</title><secondary-title>Invest Ophthalmol Vis Sci</secondary-title></titles><periodical><full-title>Invest Ophthalmol Vis Sci</full-title></periodical><pages>1622-8</pages><volume>49</volume><number>4</number><keywords><keyword>Adult</keyword><keyword>Blood Glucose/analysis</keyword><keyword>Diabetes Mellitus, Type 1/complications</keyword><keyword>Diabetes Mellitus, Type 2/complications</keyword><keyword>Diabetic Retinopathy/*diagnosis/*physiopathology</keyword><keyword>Electroretinography/*methods</keyword><keyword>Female</keyword><keyword>Follow-Up Studies</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Models, Biological</keyword><keyword>Predictive Value of Tests</keyword><keyword>Prospective Studies</keyword><keyword>ROC Curve</keyword><keyword>Reproducibility of Results</keyword><keyword>Retina/*physiopathology</keyword><keyword>Sensitivity and Specificity</keyword><keyword>Time Factors</keyword></keywords><dates><year>2008</year><pub-dates><date>Apr</date></pub-dates></dates><accession-num>18385083</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=18385083 </url></related-urls></urls></record></Cite></EndNote>uD���y������K�
_ENREF_33tD<EndNote><Cite><Author>Cuadros</Author><Year>2009</Year><RecNum>1653</RecNum><DisplayText><style face="superscript" font="Times New Roman">33</style></DisplayText><record><rec-number>1653</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">1653</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cuadros, J.</author><author>Bresnick, G.</author></authors></contributors><auth-address>University of California, Berkeley, Meredith Morgan Optometric Eye Center, Berkeley, CA 94720, USA. jcuadros@berkeley.edu</auth-address><titles><title>EyePACS: an adaptable telemedicine system for diabetic retinopathy screening</title><secondary-title>J Diabetes Sci Technol</secondary-title><alt-title>Journal of diabetes science and technology</alt-title></titles><periodical><full-title>J Diabetes Sci Technol</full-title><abbr-1>Journal of diabetes science and technology</abbr-1></periodical><alt-periodical><full-title>J Diabetes Sci Technol</full-title><abbr-1>Journal of diabetes science and technology</abbr-1></alt-periodical><pages>509-16</pages><volume>3</volume><number>3</number><edition>2010/02/11</edition><keywords><keyword>Diabetic Retinopathy/*diagnosis/pathology</keyword><keyword>Electronic Health Records</keyword><keyword>Humans</keyword><keyword>Internet</keyword><keyword>Mass Screening/*instrumentation/*methods</keyword><keyword>Referral and Consultation</keyword><keyword>Remote Consultation</keyword><keyword>Retrospective Studies</keyword><keyword>Severity of Illness Index</keyword><keyword>Software</keyword><keyword>Telemedicine/*instrumentation/*methods</keyword></keywords><dates><year>2009</year><pub-dates><date>May</date></pub-dates></dates><isbn>1932-2968 (Electronic)&#xD;1932-2968 (Linking)</isbn><accession-num>20144289</accession-num><work-type>Evaluation Studies&#xD;Research Support, Non-U.S. Gov&apos;t</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/20144289</url></related-urls></urls><custom2>2769884</custom2><language>eng</language></record></Cite></EndNote>uD���y������K�
_ENREF_34uD���y������K�
_ENREF_25uD���y������K�
_ENREF_35FD<EndNote><Cite><Author>Tyrberg</Author><Year>2011</Year><RecNum>1595</RecNum><DisplayText><style face="superscript" font="Times New Roman">35</style></DisplayText><record><rec-number>1595</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">1595</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Tyrberg, M.</author><author>Lindblad, U.</author><author>Melander, A.</author><author>Lovestam-Adrian, M.</author><author>Ponjavic, V.</author><author>Andreasson, S.</author></authors></contributors><auth-address>Department of Ophthalmology, Helsingborg Hospital, Lund University, 251 87, Helsingborg, Sweden. maria.tyrberg@med.lu.se</auth-address><titles><title>Electrophysiological studies in newly onset type 2 diabetes without visible vascular retinopathy</title><secondary-title>Doc Ophthalmol</secondary-title><alt-title>Documenta ophthalmologica. Advances in ophthalmology</alt-title></titles><periodical><full-title>Doc Ophthalmol</full-title></periodical><pages>193-8</pages><volume>123</volume><number>3</number><edition>2011/11/08</edition><keywords><keyword>Dark Adaptation/*physiology</keyword><keyword>Diabetes Mellitus, Type 2/*physiopathology</keyword><keyword>Electroretinography/*methods</keyword><keyword>Female</keyword><keyword>Follow-Up Studies</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Retina/*physiopathology</keyword><keyword>Retinal Diseases/physiopathology</keyword><keyword>Severity of Illness Index</keyword></keywords><dates><year>2011</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>1573-2622 (Electronic)&#xD;0012-4486 (Linking)</isbn><accession-num>22057379</accession-num><work-type>Comparative Study&#xD;Research Support, Non-U.S. Gov&apos;t</work-type><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/22057379</url></related-urls></urls><electronic-resource-num>10.1007/s10633-011-9298-6</electronic-resource-num><language>eng</language></record></Cite></EndNote>uD���y������K�
_ENREF_36�D<EndNote><Cite><Author>Bearse</Author><Year>2004</Year><RecNum>111</RecNum><DisplayText><style face="superscript" font="Times New Roman">36-38</style></DisplayText><record><rec-number>111</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">111</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bearse, M. A., Jr.</author><author>Han, Y.</author><author>Schneck, M. E.</author><author>Adams, A. J.</author></authors></contributors><auth-address>School of Optometry and Vision Science Program, University of California, Berkeley, Berkeley, California 94720-2020, USA. mbearse@uclink.berkeley.edu</auth-address><titles><title>Retinal function in normal and diabetic eyes mapped with the slow flash multifocal electroretinogram</title><secondary-title>Invest Ophthalmol Vis Sci</secondary-title><alt-title>Investigative ophthalmology &amp; visual science</alt-title></titles><periodical><full-title>Invest Ophthalmol Vis Sci</full-title></periodical><alt-periodical><full-title>Investigative Ophthalmology &amp; Visual Science</full-title></alt-periodical><pages>296-304</pages><volume>45</volume><number>1</number><keywords><keyword>Diabetes Mellitus, Type 1/complications/physiopathology</keyword><keyword>Diabetes Mellitus, Type 2/complications/physiopathology</keyword><keyword>Diabetic Retinopathy/etiology/*physiopathology</keyword><keyword>Electroretinography/*methods</keyword><keyword>Humans</keyword><keyword>Middle Aged</keyword><keyword>Photic Stimulation</keyword><keyword>Retina/*physiology</keyword></keywords><dates><year>2004</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>0146-0404 (Print)</isbn><accession-num>14691187</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=14691187 </url></related-urls></urls><language>eng</language></record></Cite><Cite><Author>Dhamdhere</Author><Year>2012</Year><RecNum>1592</RecNum><record><rec-number>1592</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">1592</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Dhamdhere, K. P.</author><author>Bearse, M. A., Jr.</author><author>Harrison, W.</author><author>Barez, S.</author><author>Schneck, M. E.</author><author>Adams, A. J.</author></authors></contributors><auth-address>University of California Berkeley, Berkeley, California 94720-2020, USA. drkpd@berkeley.edu</auth-address><titles><title>Associations between local retinal thickness and function in early diabetes</title><secondary-title>Invest Ophthalmol Vis Sci</secondary-title><alt-title>Investigative ophthalmology &amp; visual science</alt-title></titles><periodical><full-title>Invest Ophthalmol Vis Sci</full-title></periodical><alt-periodical><full-title>Investigative Ophthalmology &amp; Visual Science</full-title></alt-periodical><pages>6122-8</pages><volume>53</volume><number>10</number><edition>2012/08/09</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Cross-Sectional Studies</keyword><keyword>Diabetes Mellitus, Type 1/pathology/*physiopathology</keyword><keyword>Diabetes Mellitus, Type 2/pathology/*physiopathology</keyword><keyword>Diabetic Retinopathy/pathology/*physiopathology</keyword><keyword>Electroretinography</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Retina/*physiopathology</keyword><keyword>Tomography, Optical Coherence</keyword></keywords><dates><year>2012</year></dates><isbn>1552-5783 (Electronic)&#xD;0146-0404 (Linking)</isbn><accession-num>22871830</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/22871830</url></related-urls></urls><custom2>3441043</custom2><electronic-resource-num>10.1167/iovs.12-10293</electronic-resource-num><language>eng</language></record></Cite><Cite><Author>Lung</Author><Year>2012</Year><RecNum>1578</RecNum><record><rec-number>1578</rec-number><foreign-keys><key app="EN" db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">1578</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lung, J. C.</author><author>Swann, P. G.</author><author>Chan, H. H.</author></authors></contributors><auth-address>Laboratory of Experimental Optometry (Neuroscience), School of Optometry, The Hong Kong Polytechnic University, Hong Kong SAR, China.</auth-address><titles><title>Early local functional changes in the human diabetic retina: a global flash multifocal electroretinogram study</title><secondary-title>Graefes Arch Clin Exp Ophthalmol</secondary-title><alt-title>Graefe&apos;s archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie</alt-title></titles><periodical><full-title>Graefes Arch Clin Exp Ophthalmol</full-title></periodical><pages>1745-54</pages><volume>250</volume><number>12</number><edition>2012/04/25</edition><dates><year>2012</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>1435-702X (Electronic)&#xD;0721-832X (Linking)</isbn><accession-num>22527315</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/pubmed/22527315</url></related-urls></urls><electronic-resource-num>10.1007/s00417-012-2010-z</electronic-resource-num><language>eng</language></record></Cite></EndNote>b���������666666666vvvvvvvvv666666>666666666666666666666666666�6666666666�666666666666hH66666666666666666666666666666666666666666666666666666666666666666�62���� 0@P`p������2(�� 0@P`p������ 0@P`p������ 0@P`p������ 0@P`p������ 0@P`p������ 0@P`p��8X�V~PJ_HmH	nH	sH	tH	T`�TNormald%B*CJPJ_HaJmH	phsH	tH	DA �D
Default Paragraph FontRi�R
0Table Normal�4�
l4�a�(k �(
0No List6U`��6WQ50	Hyperlink>*B*ph�@�@b Q List Paragraph	^��m$N�@N	�}L0Balloon Textd�CJOJQJ^JaJR�o�!R�}L0Balloon Text CharCJOJPJQJ^JaJ.(�1.	�e�0Line Number4B4j�0Header

�H�$D�o�QDj�0Header CharB*CJPJaJph4 @b4j�0Footer

�H�$D�o�qDj�0Footer CharB*CJPJaJphPK!����[Content_Types].xml���N�0E�H���-J��@%�ǎǢ|�ș$�ز�U��L�TB� l,�3��;�r��Ø��J��B+$�G]��7O٭V��<a���(7��I��R�{�pgL�=��r���8�5v&����uQ�뉑8��C����X=��$␴�?6N�JC������F�B.ʹ'�.�+���Y�T���^e5�5�� ��ð�_�g -�;�����Yl�ݎ��|6^�N��`�?���[��PK!�֧�6_rels/.rels���j�0���}Q��%v/��C/�}�(h"���O�
����=������ ����C?�h�v=��Ʌ��%[xp��{۵_�Pѣ<�1�H�0���O�R�Bd���JE�4b$��q_����6L�R�7`������0̞O��,�En7�Li�b��/�S���e��е�����PK!ky���theme/theme/themeManager.xml�M
� @�}�w��7c�(Eb�ˮ��C�AǠҟ����7��՛K
Y,�
�e�.���|,���H�,l����xɴ��I�sQ}#Ր���� ֵ+�!�,�^�$j=�GW��)�E�+&
8���PK!0�C)��theme/theme/theme1.xml�YOo�6��w toc'vu�ر�-M�n�i���P�@�I}��úa��m�a[�إ�4�:lЯ�GR��X^�6؊�>$�������!)O�^�r�C$�y@�����/�yH*��񄴽)�޵��߻��UDb�`}"�qۋ�Jח���X^�)I`n�E���p)���li�V[]�1M<������O�P��6r�=���z�gb�Ig��u��S�eb��O������R�D۫����qu	�g��Z����o~ٺlAp�lx�pT0���+[}`j���zA��V�2�F���i�@�q�v�֬5\|��ʜ̭N��le�X�ds���jcs���7���f����
��W��+�Ն�7����`���g�Ș��J���j|��h(�K��D-����
dX��iJ�؇(��x$(��:��;�˹!�I_�T��S1�����?E��?�����?ZBΪm���U/������?�~����xY���'���y5�g&΋/����ɋ�>���G�M�Ge���D�����3Vq%'#q�����$�8��K�����)f�w9:ĵ��
x}r�x����w���r�:\TZaG�*�y8I�j�bR��c|XŻ�ǿ�I
u3KG�nD1�NIB�s���
��R��u���K>V�.EL+M2�#'�f��i~�V��vl�{u8��z��H�
�*���:�(W�☕
~��J�T�e\O*�tHG��HY��}KN�P�*ݾ˦���TѼ�9/#��A7�qZ��$*c?���qU��n��w�N��%��O��i�4=3��N���)cbJ
u�V�4����(Tn���
7��_?���m-ٛ�{U���B�w�<w���_���$�#��[Ի�8{���(�/�$Ϫ0h݋�F۴��®{L�)#7�i�%�=A�:s�$�),��Qg20pp��f
\}DU4�p
M{��DB��%J������+{�l�C���]��=��5
2F��hsF+��Y��\Ɉ�n�ì��:3���E�[��6�9����`��&45Z!��*��5k8�`Fmw��-��"�d>�z��n���ʜ"Z��x��J�Z��p;�������{/�<�P;��,)''K�Q�k5���q��pN��8�K�Gb�e���
�S��d�̛�\17	�p�a�>��SR!���

3��K4'+�r�zQ
TT��I����Ivt]K�c⫲�K#�v�5+�|��D������~��O@%\w���_�nN[�L��9K���q��g�V�h��n
R!�y+��U�n�;�*&�/H�r��T�	�>��>\
�t��=.Tġ
���S; Z�~�!����P��9gi���C�ڧ!�#	B��,��;�X=ۻ,I�2UW�V�9$l�k���=A��j���;�{�A�P79�|s*Y�����;�̠�[�MC�ۿ�hf��]o��{oY=1k�yV��V���5E8�Vk+֜���\8���0X4D)�!!��?*|f�v�
u���"�x��A�@T_������q��6�4)kڬu�V�7��t�'��%;���i�9s�9�x���,��ڎ-45x�d���8?�ǘ�d�/Y|t��&LIL�J`�& �-G�t�/��PK!
ѐ��'theme/theme/_rels/themeManager.xml.rels��M
�0���wooӺ�&݈Э���5
6?$Q��
�,.�a��i����c2�1h�:�q��m��@RN��;d�`��o7�g�K(M&$R(.1�r'J��ЊT���8��V�"��AȻ�H�u}��|�$�b{��P����8�g/]�QAsم(����#��L�[������PK-!����[Content_Types].xmlPK-!�֧�60_rels/.relsPK-!ky���theme/theme/themeManager.xmlPK-!0�C)���theme/theme/theme1.xmlPK-!
ѐ��'�	theme/theme/_rels/themeManager.xml.relsPK]�
<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<a:clrMap xmlns:a="http://schemas.openxmlformats.org/drawingml/2006/main" bg1="lt1" tx1="dk1" bg2="lt2" tx2="dk2" accent1="accent1" accent2="accent2" accent3="accent3" accent4="accent4" accent5="accent5" accent6="accent6" hlink="hlink" folHlink="folHlink"/> ������	+++.c`��"�(�9�<jJ\T�WY�[�]�b�h�k�x����� �W[]^_`abcdefghjklnopqa
��f`Aw!����� �XYZ\imrst2?7G]_`�������
�
�
�
�
�
�
�
$&'���Y[\V�����W�����������456lmn�� ST� � � 5!f!g!�'�'�'�(�(�(�/�/�/j0�0�0�0�0�0�0�022223242j2m2p2�2�2�23E3F3V3l3m3p3q36G6H6X6n6o6r6s678797�>�>�>ABQBgBhBiB�B�B�B�B�B�B�C�C�C�J�J�J�M�M�MNNNNN:OJO`OaObO�O�O�O�O�O�OmP}P�P�P�P�P�P�PQQ	Q�S�S�S�S�S�S�ST6T9T:T�T�TUUU:U=U@UtUzU{U�V�V�V�VWW
WWR`�`�`�`�`�`�`�`4aiajaza�a�a�a�a�c0d1d]j`jaj�v�v�vy~|~}~�~�~�~�~�~�~�R�S�c�y�z�����(�;�� �X���QQ�D��X���X��̕�QQ�D��X���X��̕�X�Q���ĕ�X�Q���ĕ�X�QQ�@��̕�Xt���X����X���X���X�Q���̕�X�Q���̕�X�Q���̕�X�QQ�@���̕�QQ�@�X���X��̕�X�QQ�@��̕�X�QQ�@���̕�X�Q���̕�QQ�@��X���X��̕�X�Q��̕�X�QQ�@��̕�QQ�@�X���X��̕�QQ�@�X���X��̕�QQ�@�X���X��̕�QQ�@�X���X��̕�X�QQ�@��̕�X�QQ�@���̕�X�QQ�@��̕�X�Q���̕�X�Q��̕�X�QQ�@��̕�X�QQ�@��̕�Q����$'.!�����L�#����@�����������0�(	�
��B
�S����	?���&_ENREF_1_ENREF_2_ENREF_3_ENREF_4_ENREF_5_ENREF_6_ENREF_7_ENREF_8_ENREF_9	_ENREF_10	_ENREF_11	_ENREF_12	_ENREF_13	_ENREF_14	_ENREF_15	_ENREF_16	_ENREF_17	_ENREF_18	_ENREF_19	_ENREF_20	_ENREF_21	_ENREF_22	_ENREF_23	_ENREF_24	_ENREF_25	_ENREF_26	_ENREF_27	_ENREF_28	_ENREF_29	_ENREF_30	_ENREF_31	_ENREF_32	_ENREF_33	_ENREF_34	_ENREF_35	_ENREF_36	_ENREF_37	_ENREF_38<����n�H�̋z�*�ύj�؎��
������̒X������̖f��̘��������ܝ��g���Ҡ��i�-�!�	

 !"#$%߈��m�G�ˋy�)�΍i�׎��������˒W������˖e��˘��������۝��f���Ѡ��h�,��!�<B����v�O(Y(W0a00C5C�U�U�W�W�\�\``�`�`ccBcHc�j�j�k�k^pap�p�p�p�p1q5qSqWq�q�q�q�q!r#rFrHr�~�~��9�@���!�%�;�@�������������������!�!MY��
�
n
~
�/�/55N56�>?"?/?�?�?*L6L�L�LNMeM�N�N�OPQQ"Q-Q�Q�Q�QR�R�R�R�R�Y3Z]]{]�]^%^�^�^C_M_�`�`�a�b�k�k�m;n^nfn$p(p�q�q:r@r�u�u�~�~9�I�P�d�āف����_�j�����������������������!�333333333333333333333333333333333333333333333��^`���0�0232V3m3X6o6QBhBNNJOaO}P�P�S�S�TU�VW�`�`za�a�~�~c�z�ŇŇɇ؇������!�yl��T?���������*=�$��c������������(���^��`�(�OJQJo(���������^��`���OJQJ^Jo(o��p����p^�p`���OJQJo(����@����@^�@`���OJQJo(��������^�`���OJQJ^Jo(o��������^��`���OJQJo(����������^��`���OJQJo(����������^��`���OJQJ^Jo(o��P����P^�P`���OJQJo(�����(���^��`�(�OJQJo(����������^��`���OJQJ^Jo(o��p����p^�p`���OJQJo(����@����@^�@`���OJQJo(��������^�`���OJQJ^Jo(o��������^��`���OJQJo(����������^��`���OJQJo(����������^��`���OJQJ^Jo(o��P����P^�P`���OJQJo(��*=�$yl���������������								��&								09�>G�F�S�c#RRw�%�)�I �G"]A%�i(04{M8�;�S<�O=�?F�H{L-)P:VS�Z�EZu]�r^�9_jj�j�r�s��!y��	��&����}�����
�U�V^��R��r��#��!�:	��*���	����`��z����>�`�90�l�p��E��c�_f�#F��{��?��J��fH�J#�Cj������EN.InstantFormat	EN.LayoutEN.Libraries�<ENInstantFormat><Enabled>1</Enabled><ScanUnformatted>1</ScanUnformatted><ScanChanges>1</ScanChanges><Suspended>0</Suspended></ENInstantFormat>�<ENLayout><Style>OVS_2008</Style><LeftDelim>{</LeftDelim><RightDelim>}</RightDelim><FontName>Times New Roman</FontName><FontSize>12</FontSize><ReflistTitle></ReflistTitle><StartingRefnum>1</StartingRefnum><FirstLineIndent>0</FirstLineIndent><HangingIndent>0</HangingIndent><LineSpacing>0</LineSpacing><SpaceAfter>3</SpaceAfter><HyperlinksEnabled>1</HyperlinksEnabled><HyperlinksVisible>0</HyperlinksVisible></ENLayout>�<Libraries><item db-id="0w0dzs9dp5edxaewepyverd20wxedvfp9drt">MasterLibrary_12_2008<record-ids><item>110</item><item>111</item><item>173</item><item>378</item><item>443</item><item>450</item><item>452</item><item>538</item><item>685</item><item>691</item><item>703</item><item>881</item><item>1329</item><item>1402</item><item>1466</item><item>1577</item><item>1578</item><item>1582</item><item>1584</item><item>1585</item><item>1592</item><item>1595</item><item>1599</item><item>1600</item><item>1602</item><item>1625</item><item>1639</item><item>1643</item><item>1648</item><item>1650</item><item>1653</item></record-ids></item></Libraries>�@ �p@��Unknown������������	G��*�Ax�	�Times New Roman5��Symbol3.��*�Cx�	�Arial7.���@�CalibriC��	�����(PMingLiU�e0}fԚ5.��.�[`�)�Tahoma;��Wingdings?=�	�*�Cx�	�Courier NewA���$B�Cambria Math"q���hQ{GB['�[�Qx{�S)x{�S)Y�������24����3K�Q���HX	�$P����������������������	8?2!xx����JNGJNG����Oh��+'��0d�������	��
 ,
8DLT\�JNGNormal.dotmJNG21Microsoft Office Word@&�P@jdB��@FDF]��@l�J��x{�����՜.��+,��D��՜.��+,��4�hp��������
���Microsoft)S��Title� 8@_PID_HLINKS�AX�B�
_ENREF_36B�
_ENREF_35C�
_ENREF_25B�
_ENREF_34B�
_ENREF_33B�
_ENREF_32C�
_ENREF_29C�
_ENREF_25C�
_ENREF_21C�
_ENREF_25C�
_ENREF_21C�
_ENREF_25C�
_ENREF_21C�
_ENREF_25C�
_ENREF_24C�
_ENREF_23C
_ENREF_22C{
_ENREF_21@x
_ENREF_11Cn
_ENREF_20@f
_ENREF_11@^
_ENREF_19@Z
_ENREF_18@W
_ENREF_17@K
_ENREF_13@E
_ENREF_14@?
_ENREF_13@9
_ENREF_12E6	_ENREF_4E3	_ENREF_4E0	_ENREF_4E-	_ENREF_4E%	_ENREF_4B	_ENREF_3C	_ENREF_2C	_ENREF_2@	_ENREF_1C
	_ENREF_2@	_ENREF_1
5mailto:jng@scco.edu	

 !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstu����wxyz{|}~��������������������������������������������������������������������������������������������������������������������������������	

 !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~��������������������������������������������������������������������������������������������������������������������������������	

 !"#$%&'()*+,-./0123456789:;<=>?@AB����DEFGHIJKLMNOPQRSTUVWXYZ[\]^_`a����cdefghi����klmnopq������������������������x��������������������������������Root Entry��������	�F`�K��z�Data
������������vX�1Table����Cn=WordDocument����;�SummaryInformation(������������bDocumentSummaryInformation8��������jCompObj������������r������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������
����	�F Microsoft Word 97-2003 Document
MSWordDocWord.Document.8�9�q

Youez - 2016 - github.com/yon3zu
LinuXploit