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Table Classic 1;}{\*\ts32\tsrowd\tsbrdrb\brdrs\brdrw15\brdrcf1 \tsbrdrdgl\brdrnil\tsbrdrdgr\brdrnil \rtlch\fcs1 \af1 \ltrch\fcs0 \tscfirstrow Table Classic 1;}{\*\ts32\tsrowd\tsbrdrt\brdrs\brdrw15\brdrcf1 \tsbrdrdgl\brdrnil\tsbrdrdgr\brdrnil \rtlch\fcs1 
\af1 \ltrch\fcs0 \tsclastrow Table Classic 1;}{\*\ts32\tsrowd\tsbrdrr\brdrs\brdrw15\brdrcf1 \tsbrdrdgl\brdrnil\tsbrdrdgr\brdrnil \rtlch\fcs1 \af1 \ltrch\fcs0 \tscfirstcol Table Classic 1;}{\*\ts32\tsrowd\tsbrdrdgl\brdrnil\tsbrdrdgr\brdrnil \rtlch\fcs1 
\af1 \ltrch\fcs0 \tscnecell Table Classic 1;}{\*\ts32\tsrowd\tsbrdrdgl\brdrnil\tsbrdrdgr\brdrnil \rtlch\fcs1 \af1 \ltrch\fcs0 \tscswcell Table Classic 1;}{\s33\ql \li0\ri0\widctlpar
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\additive \rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \f0\fs24 \sbasedon10 \slink33 \slocked \ssemihidden Header Char;}{\*\cs35 \additive \rtlch\fcs1 \af0 \ltrch\fcs0 \sbasedon10 \styrsid11476431 page number;}{\*\ts36\tsrowd\trbrdrt\brdrs\brdrw15\brdrcf1 \trbrdrl
\brdrs\brdrw15\brdrcf1 \trbrdrb\brdrs\brdrw15\brdrcf1 \trbrdrr\brdrs\brdrw15\brdrcf1 \trbrdrh\brdrs\brdrw15\brdrcf1 
\trftsWidthB3\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblind0\tblindtype3\tscellwidthfts0\tsvertalt\tsbrdrt\tsbrdrl\tsbrdrb\tsbrdrr\tsbrdrdgl\tsbrdrdgr\tsbrdrh\tsbrdrv 
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Table List 5;}{\*\ts36\tsrowd\tsbrdrb\brdrs\brdrw30\brdrcf1 \tsbrdrdgl\brdrnil\tsbrdrdgr\brdrnil \rtlch\fcs1 \af1 \ltrch\fcs0 \tscfirstrow Table List 5;}{\*\ts36\tsrowd\tsbrdrdgl\brdrnil\tsbrdrdgr\brdrnil \rtlch\fcs1 \af1 \ltrch\fcs0 \tscfirstcol 
Table List 5;}{\*\cs37 \additive \rtlch\fcs1 \af0 \ltrch\fcs0 \sbasedon10 \styrsid12215024 apple-converted-space;}{\*\cs38 \additive \rtlch\fcs1 \af0 \ltrch\fcs0 \sbasedon10 \styrsid6905929 yiv908388109highlight;}{\*\cs39 \additive \rtlch\fcs1 \af0 
\ltrch\fcs0 \sbasedon10 \styrsid6905929 yiv908388109apple-converted-space;}{\*\cs40 \additive \rtlch\fcs1 \af0 \ltrch\fcs0 \sbasedon10 \styrsid7735601 authorlist;}{\*\cs41 \additive \rtlch\fcs1 \af0 \ltrch\fcs0 \sbasedon10 \styrsid3691968 unicode;}{\*
\cs42 \additive \rtlch\fcs1 \af0\afs16 \ltrch\fcs0 \fs16 \sbasedon10 \ssemihidden \styrsid7940057 annotation reference;}{\s43\ql \li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0 \rtlch\fcs1 \af0\afs20\alang1025 
\ltrch\fcs0 \fs20\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 \sbasedon0 \snext43 \slink44 \ssemihidden \styrsid7940057 annotation text;}{\*\cs44 \additive \rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \f0\fs20 
\sbasedon10 \slink43 \slocked \ssemihidden \styrsid7940057 Comment Text Char;}{\s45\ql \li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0 \rtlch\fcs1 \ab\af0\afs20\alang1025 \ltrch\fcs0 
\b\fs20\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 \sbasedon43 \snext43 \slink46 \ssemihidden \styrsid7940057 annotation subject;}{\*\cs46 \additive \rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \b\f0\fs20 
\sbasedon44 \slink45 \slocked \ssemihidden \styrsid7940057 Comment Subject Char;}{\s47\ql \li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0 \rtlch\fcs1 \af36\afs16\alang1025 \ltrch\fcs0 
\f36\fs16\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 \sbasedon0 \snext47 \slink48 \ssemihidden \styrsid7940057 Balloon Text;}{\*\cs48 \additive \rtlch\fcs1 \af36\afs16 \ltrch\fcs0 \f36\fs16 
\sbasedon10 \slink47 \slocked \ssemihidden \styrsid7940057 Balloon Text Char;}}
{\*\latentstyles\lsdstimax156\lsdlockeddef0{\lsdlockedexcept Normal;heading 1;heading 2;heading 3;heading 4;heading 5;heading 6;heading 7;heading 8;heading 9;toc 1;toc 2;toc 3;toc 4;toc 5;toc 6;toc 7;toc 8;toc 9;caption;Title;Default Paragraph Font;Subtitle;Strong;Emphasis;Table Grid;}}
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{\pntxta )}}{\*\pnseclvl5\pndec\pnqc\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}{\*\pnseclvl6\pnlcltr\pnqc\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}{\*\pnseclvl7\pnlcrm\pnqc\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}
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\b\fs28\insrsid9469842\charrsid726654 linical }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \b\fs28\insrsid2373300\charrsid726654 P}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \b\fs28\insrsid9469842\charrsid726654 arameters on }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 
\b\fs28\insrsid2373300\charrsid726654 Laryngeal M}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \b\fs28\insrsid9469842\charrsid726654 ucin }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \b\fs28\insrsid2373300\charrsid726654 G}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 
\b\fs28\insrsid9469842\charrsid726654 ene }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \b\fs28\insrsid2373300\charrsid726654 E}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \b\fs28\insrsid9469842\charrsid726654 xpression
\par }\pard \ltrpar\qc \li0\ri0\sl360\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16270948 {\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \b\fs28\insrsid2191905\charrsid726654 
\par }\pard \ltrpar\qj \li0\ri0\sb120\sl360\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid3153089 {\rtlch\fcs1 \af0 \ltrch\fcs0 \b\insrsid3153089\charrsid726654 
\par }\pard \ltrpar\ql \li0\ri0\sb120\sl360\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid1783081 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid3153089\charrsid726654 M}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 
\b\insrsid1783081\charrsid726654 ahmoud}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid3153089\charrsid726654  S}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid9771510\charrsid726654 .}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid3153089\charrsid726654  Ali}{
\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\super\insrsid11143403\charrsid726654 1}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\super\insrsid13729304\charrsid726654 ,2}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid3153089\charrsid726654 *}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 
\b\insrsid9534871\charrsid726654  }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid2630793\charrsid726654 MSC, FRCS, }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid9534871\charrsid726654 MD}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid1268028\charrsid726654 ,}{
\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid3153089\charrsid726654  D}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid1783081\charrsid726654 avid}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid1865035\charrsid726654  }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 
\b\insrsid3153089\charrsid726654 M}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid9771510\charrsid726654 .}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid3153089\charrsid726654  Bulmer}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\super\insrsid3153089\charrsid726654 2}{
\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\super\insrsid9534871\charrsid726654  }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid9534871\charrsid726654 PhD,}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid3153089\charrsid726654  }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 
\b\insrsid1865035\charrsid726654 P}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid1783081\charrsid726654 eter}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid1865035\charrsid726654  Dettmar}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\super\insrsid1865035\charrsid726654 3}
{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid16675513\charrsid726654 PhD, }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\lang2057\langfe1041\langfenp1041\insrsid1865035\charrsid726654  J}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 
\b\lang2057\langfe1041\langfenp1041\insrsid1783081\charrsid726654 effrey}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\lang2057\langfe1041\langfenp1041\insrsid3153089\charrsid726654  P}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 
\b\lang2057\langfe1041\langfenp1041\insrsid9771510\charrsid726654 .}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\lang2057\langfe1041\langfenp1041\insrsid3153089\charrsid726654  Pearson}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 
\b\lang2057\langfe1041\super\langfenp1041\insrsid11143403\charrsid726654 2}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\lang2057\langfe1041\super\langfenp1041\insrsid9534871\charrsid726654  }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid9534871\charrsid726654 PhD.}{
\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\lang2057\langfe1041\langfenp1041\insrsid3153089\charrsid726654 
\par }\pard \ltrpar\qj \li0\ri0\sb120\sl360\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid3153089 {\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1041\super\langfenp1041\insrsid3153089\charrsid726654 1}{\rtlch\fcs1 
\af0 \ltrch\fcs0 \lang2057\langfe1041\langfenp1041\insrsid3153089\charrsid726654 Department of Otolaryngology, {\*\xmlopen\xmlns2{\factoidname PlaceName}}Mansoura{\*\xmlclose} {\*\xmlopen\xmlns2{\factoidname PlaceType}}University{\*\xmlclose} 
{\*\xmlopen\xmlns2{\factoidname PlaceType}}Hospital{\*\xmlclose}, {\*\xmlopen\xmlns2{\factoidname City}}{\*\xmlopen\xmlns2{\factoidname place}}{\*\xmlopen\xmlns2{\factoidname City}}Mansoura University{\*\xmlclose}, {\*\xmlopen\xmlns2{\factoidname 
country-region}}Egypt{\*\xmlclose}{\*\xmlclose}{\*\xmlclose}.
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1041\super\langfenp1041\insrsid3153089\charrsid726654 2}{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1041\langfenp1041\insrsid3153089\charrsid726654 Institute for Cell and Molecular Biosciences, 
{\*\xmlopen\xmlns2{\factoidname PlaceName}}Newcastle{\*\xmlclose} {\*\xmlopen\xmlns2{\factoidname PlaceType}}University{\*\xmlclose}, Faculty of Medical Sciences, {\*\xmlopen\xmlns2{\factoidname City}}{\*\xmlopen\xmlns2{\factoidname place}}
{\*\xmlopen\xmlns2{\factoidname City}}Newcastle upon Tyne}{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1041\langfenp1041\insrsid9534871\charrsid726654 {\*\xmlclose}, {\*\xmlopen\xmlns2{\factoidname country-region}}UK}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang2057\langfe1041\langfenp1041\insrsid3153089\charrsid726654 {\*\xmlclose}{\*\xmlclose}{\*\xmlclose}.}{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1041\super\langfenp1041\insrsid3153089\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang2057\langfe1041\langfenp1041\insrsid3153089\charrsid726654 
\par }\pard \ltrpar\qj \li0\ri0\sb120\sl360\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid1865035 {\rtlch\fcs1 \af0 \ltrch\fcs0 \super\insrsid1865035\charrsid726654 3}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid1865035\charrsid726654 Castle Hill hospital, {\*\xmlopen\xmlns2{\factoidname address}}{\*\xmlopen\xmlns2{\factoidname Street}}Castle Road{\*\xmlclose}{\*\xmlclose}, Cottingham, East Yorkshire, UK
\par }\pard \ltrpar\qj \li0\ri0\sb120\sl360\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid3153089 {\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1041\langfenp1041\insrsid3153089\charrsid726654 
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1041\langfenp1041\insrsid1466394\charrsid726654 
\par }\pard \ltrpar\qj \li0\ri0\sb120\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid3153089 {\rtlch\fcs1 \af0 \ltrch\fcs0 \b\lang2057\langfe1041\langfenp1041\insrsid3153089\charrsid726654 *Corresponding author}{\rtlch\fcs1 
\af0 \ltrch\fcs0 \lang2057\langfe1041\langfenp1041\insrsid3153089\charrsid726654 : }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid3153089\charrsid726654 M. S. Ali}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\super\insrsid3153089\charrsid726654 
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3153089\charrsid726654 E-mail address: msamomar@yahoo.co.uk
\par }\pard \ltrpar\qj \li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16273839 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12389985\charrsid726654 
\par }\pard \ltrpar\qj \li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid14514815 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14514815\charrsid726654 Postal a}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16273839\charrsid726654 
ddress: }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid2191905\charrsid726654 
\par }\pard \ltrpar\qj \li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid16273839 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid2191905\charrsid726654 In {\*\xmlopen\xmlns2{\factoidname country-region}}
{\*\xmlopen\xmlns2{\factoidname place}}Egypt{\*\xmlclose}{\*\xmlclose}: }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1041\langfenp1041\insrsid16273839\charrsid726654 Department of Otolaryngology, 
\par }\pard \ltrpar\qj \li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid12389985 {\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1041\langfenp1041\insrsid16273839\charrsid726654                }{\rtlch\fcs1 \af0 
\ltrch\fcs0 \lang2057\langfe1041\langfenp1041\insrsid2191905\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1041\langfenp1041\insrsid16273839\charrsid726654 {\*\xmlopen\xmlns2{\factoidname PlaceName}}{\*\xmlopen\xmlns2{\factoidname place}}
{\*\xmlopen\xmlns2{\factoidname PlaceName}}Mansoura{\*\xmlclose} {\*\xmlopen\xmlns2{\factoidname PlaceType}}University{\*\xmlclose} {\*\xmlopen\xmlns2{\factoidname PlaceType}}Hospital{\*\xmlclose}{\*\xmlclose}{\*\xmlclose}, 
\par              }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1041\langfenp1041\insrsid2191905\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1041\langfenp1041\insrsid16273839\charrsid726654   {\*\xmlopen\xmlns2{\factoidname PlaceName}}
{\*\xmlopen\xmlns2{\factoidname place}}{\*\xmlopen\xmlns2{\factoidname PlaceName}}Mansoura{\*\xmlclose} {\*\xmlopen\xmlns2{\factoidname PlaceType}}University{\*\xmlclose}{\*\xmlclose}{\*\xmlclose}, 
\par              }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1041\langfenp1041\insrsid2191905\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1041\langfenp1041\insrsid16273839\charrsid726654   {\*\xmlopen\xmlns2{\factoidname country-region}}
{\*\xmlopen\xmlns2{\factoidname place}}Egypt}{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1041\langfenp1041\insrsid3153089\charrsid726654 {\*\xmlclose}{\*\xmlclose}
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1041\langfenp1041\insrsid2191905\charrsid726654 
\par }\pard \ltrpar\qj \li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid2191905 {\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1041\langfenp1041\insrsid2191905\charrsid726654 In the {\*\xmlopen\xmlns2{\factoidname 
country-region}}{\*\xmlopen\xmlns2{\factoidname place}}UK{\*\xmlclose}{\*\xmlclose}: {\*\xmlopen\xmlns2{\factoidname address}}{\*\xmlopen\xmlns2{\factoidname Street}}29 Brookside Crescent{\*\xmlclose}{\*\xmlclose}
\par                   {\*\xmlopen\xmlns2{\factoidname place}}Newcastle upon Tyne{\*\xmlclose}
\par                   NE5 3NA
\par }\pard \ltrpar\qj \li0\ri0\sb120\sl360\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid7235050 {\rtlch\fcs1 \af0 \ltrch\fcs0 \lang2057\langfe1041\langfenp1041\insrsid12389985\charrsid726654 Tel: 07868710121
\par }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid9112123\charrsid726654 
\par }\pard\plain \ltrpar\s3\ql \li0\ri0\sb120\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel2\adjustright\rin0\lin0\itap0\pararsid16216415 \rtlch\fcs1 \ab\af0\afs27\alang1025 \ltrch\fcs0 
\b\fs27\lang2057\langfe2057\loch\af0\hich\af0\dbch\af38\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid3153089\charrsid726654 \page }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid16216415\charrsid726654 
\hich\af0\dbch\af38\loch\f0 Abstract 
\par }\pard\plain \ltrpar\s4\ql \li0\ri0\sb120\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel3\adjustright\rin0\lin0\itap0\pararsid16216415 \rtlch\fcs1 \ab\af0\afs24\alang1025 \ltrch\fcs0 
\b\fs24\lang2057\langfe2057\loch\af0\hich\af0\dbch\af38\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0 Objectives: }{\rtlch\fcs1 \af0 \ltrch\fcs0 \b0\insrsid15082033\charrsid726654 
\hich\af0\dbch\af38\loch\f0 Previous research had reported altered mucin expression in laryngeal mucosa in reflux cases. }{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0 This study ai
\hich\af0\dbch\af38\loch\f0 ms to investigate the impact of reflux severity measured by reflux symptoms index (RSI) and reflux findings score (RFS) on laryngeal }{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \cs18\b0\insrsid16216415\charrsid726654 
\hich\af0\dbch\af38\loch\f0 mucin}{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0  }{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \cs18\b0\insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0 gene}{\rtlch\fcs1 
\ab0\af0 \ltrch\fcs0 \b0\insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0  }{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid1802172\charrsid726654 \hich\af0\dbch\af38\loch\f0 (MUC) }{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 
\b0\insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0 expression. }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16216415\charrsid726654 
\par }\pard\plain \ltrpar\ql \li0\ri0\sb120\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid16216415 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 
\b\insrsid16216415\charrsid726654 Study Design:}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16216415\charrsid726654  Experimental study. 
\par }\pard\plain \ltrpar\s4\ql \li0\ri0\sb120\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel3\adjustright\rin0\lin0\itap0\pararsid16216415 \rtlch\fcs1 \ab\af0\afs24\alang1025 \ltrch\fcs0 
\b\fs24\lang2057\langfe2057\loch\af0\hich\af0\dbch\af38\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0 Setting:}{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid16216415\charrsid726654 
\hich\af0\dbch\af38\loch\f0  Tertiary care referral university hospital.}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16216415\charrsid726654 
\par }\pard \ltrpar\s4\ql \li0\ri0\sb120\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel3\adjustright\rin0\lin0\itap0\pararsid12586388 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0 Methods}{
\rtlch\fcs1 \af0 \ltrch\fcs0 \cs18\insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0 : }{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0 In situ hybridisation was employed on 2 }{\rtlch\fcs1 
\ab0\af0 \ltrch\fcs0 \b0\insrsid7605085\charrsid726654 \hich\af0\dbch\af38\loch\f0 control }{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0 and 3}{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 
\b0\insrsid1579750\charrsid726654 \hich\af0\dbch\af38\loch\f0 1}{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0  patients}{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid7605085\charrsid726654 
\loch\af0\dbch\af38\hich\f0 \rquote }{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0  laryngeal mucosa to investigate}{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid5449782\charrsid726654 
\hich\af0\dbch\af38\loch\f0  the}{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0  }{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid5449782\charrsid726654 \hich\af0\dbch\af38\loch\f0 expression of the first 8 }
{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0 mucin gene}{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid5449782\charrsid726654 \hich\af0\dbch\af38\loch\f0 s (MUC1-4, 5AC, 5B, 6 and 7)}{\rtlch\fcs1 \ab0\af0 
\ltrch\fcs0 \b0\insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0  in mild and severe reflux based on RSI and RFS. }{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid5449782\charrsid726654 \hich\af0\dbch\af38\loch\f0 
Reflux patients were classified into 4 groups (Low and high RSI scores of 0-13 and 14-45 respectively, and low and high RFS scores of 0-7 and 8-26 respectively).}{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid5335386\charrsid726654 
\hich\af0\dbch\af38\loch\f0  Mucin gene expression }{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid12586388\charrsid726654 \hich\af0\dbch\af38\loch\f0 was analysed }{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid5335386\charrsid726654 
\hich\af0\dbch\af38\loch\f0 in these groups }{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid12586388\charrsid726654 \hich\af0\dbch\af38\loch\f0 and compare to control mucosa. }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16216415\charrsid726654 
\par }\pard \ltrpar\s4\ql \li0\ri0\sb120\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel3\adjustright\rin0\lin0\itap0\pararsid12805954 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0 Results:}{
\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0  }{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid1802172\charrsid726654 \hich\af0\dbch\af38\loch\f0 Th\hich\af0\dbch\af38\loch\f0 e expression of m}{\rtlch\fcs1 
\ab0\af0 \ltrch\fcs0 \b0\insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0 ucin}{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid1469141\charrsid726654 \hich\af0\dbch\af38\loch\f0 s }{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 
\b0\insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0 MUC3, 4 and 5AC was down regulated in patients with low RSI compared to }{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid12018979\charrsid726654 \hich\af0\dbch\af38\loch\f0 control}{\rtlch\fcs1 
\ab0\af0 \ltrch\fcs0 \b0\insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0  mucosa. In high RSI mucosa, }{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid10028969\charrsid726654 \hich\af0\dbch\af38\loch\f0 MUC}{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 
\b0\insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0 3 and 4 were up regulated approaching the expression of }{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid12805954 \hich\af0\dbch\af38\loch\f0 control}{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 
\b0\insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0  mucosa with significantly higher expression compared to lo\hich\af0\dbch\af38\loch\f0 w RSI mucosa. MUC5AC down regulation was maintained. High RFS mucosa showed a trend toward increased }{
\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid10028969\charrsid726654 \hich\af0\dbch\af38\loch\f0 MUC}{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0 
3 and 4 expression compared to low RFS mucosa but MUC5AC expression was significantly lower in both RFS groups compared to }{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid12805954 \hich\af0\dbch\af38\loch\f0 control}{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 
\b0\insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0 . When squamous mucosa\hich\af0\dbch\af38\loch\f0 l samples were excluded, MUC5AC expression patterns did not change. 
\par }\pard \ltrpar\s4\ql \li0\ri0\sb120\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\outlinelevel3\adjustright\rin0\lin0\itap0\pararsid9382270 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0 
Conclusions: }{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \cs18\b0\insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0 There is a differential pattern of }{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \cs18\b0\insrsid10028969\charrsid726654 \hich\af0\dbch\af38\loch\f0 
MUC}{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \cs18\b0\insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0 3 and 4 expression in reflux patient\hich\f0 \rquote \loch\f0 
s laryngeal mucosa based on reflux severity. MUC5AC is down regulated by mild and severe reflux and\hich\af0\dbch\af38\loch\f0  this }{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \cs18\b0\insrsid9382270\charrsid726654 \hich\af0\dbch\af38\loch\f0 could }{\rtlch\fcs1 
\ab0\af0 \ltrch\fcs0 \cs18\b0\insrsid16216415\charrsid726654 \hich\af0\dbch\af38\loch\f0 contribute to the continuation of reflux symptoms and development of  laryngeal mucosal changes.}{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid16216415\charrsid726654 

\par }\pard\plain \ltrpar\qj \li0\ri0\sb120\sl360\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid13137573 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {
\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid13137573\charrsid726654 Key words}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid13137573\charrsid726654 : Mucin gene, l}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13137573\charrsid726654 
aryngopharyngeal reflux, RSI, RFS, MUC3, MUC4, MUC5AC. }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid13137573\charrsid726654 
\par }\pard \ltrpar\ql \li0\ri0\sb120\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid12389619 {\rtlch\fcs1 \af0 \ltrch\fcs0 \b\insrsid12389619\charrsid726654 Introduction
\par }\pard \ltrpar\ql \li0\ri0\sb120\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid1341912 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 
Mucus is important in the upper airways as the secreted mucin genes (}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid10028969\charrsid726654 MUC}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 
 2, 5AC and 5B in particular) provide a surface gel which protects the underlying mucosa from exogenous and endogenous damaging agents}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \super\insrsid11871710\charrsid726654  }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 
\insrsid11871710\charrsid726654 [1]}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 .}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12389619\charrsid726654  A}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 
ltered laryngeal mucin gene expression by local mucosal insult created by refluxate components (acid, enzymes, bile, etc...) could result in}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid12018979\charrsid726654  a}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 
\insrsid12389619\charrsid726654  less protected laryngeal mucosa when mucus secretion is }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid11021149\charrsid726654 reduced}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 
 or globus pharyngeal sensation}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid11021149\charrsid726654 , }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 throat irritation }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid11021149\charrsid726654 
and cough }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 when mucus secretion is increased. These are common symptoms of }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \cf6\insrsid6256775\charrsid6256775 laryngopharyngeal reflux}{\rtlch\fcs1 
\ab\af0 \ltrch\fcs0 \insrsid6256775  (}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 LPR}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid6256775 )}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 
.  Altered mucin gene expression can also be involved in the laryngeal mucosal changes }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid11871710\charrsid726654 [2] }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 noted in reflux patients}{
\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid13395081\charrsid726654  such as }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid1341912\charrsid726654 v}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1341912\charrsid726654 ocal fold polyps, Ventricular }{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid11828017\charrsid726654 oedema}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1341912\charrsid726654 , Subglottic edema and Laryngeal granuloma}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11871710\charrsid726654  [3]}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 
\insrsid12389619\charrsid726654 . 
\par }\pard \ltrpar\ql \li0\ri0\sb120\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid9175878 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid9175878\charrsid726654 
The literature on mucin gene expression in laryngeal mucosa of patients with laryngopharyngeal reflux (LPR) is scarce. }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9175878\charrsid726654 Johnston et al }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid11871710\charrsid726654 [2] }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9175878\charrsid726654 have reported MUC5AC down regulation in laryngeal mucosal samples from 10 patients compared to normal laryngeal mucosa. Samuels et al}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid11871710\charrsid726654  [4]}{\rtlch\fcs1 \af0 \ltrch\fcs0 \super\insrsid11871710\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9175878\charrsid726654 
have compared mucin gene expression in laryngeal biopsies from 3 patients with LPR and two control subjects. They}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid9175878\charrsid726654  have reported reduced mucin gene (MUC)}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid9175878\charrsid726654  2, 3, and 5 expression}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13395081\charrsid726654  in LPR}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9175878\charrsid726654 . While these mucin genes were up-regu
lated after exposure to low pH in vitro, pepsin inhibited this up-regulation. 
\par }\pard \ltrpar\ql \li0\ri0\sb120\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid7084843 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 
LPR can alter laryngeal mucin gene expression through a direct effect on gene expression}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid12018979\charrsid726654  in the}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 
 laryngeal  mucosa and/or by stimulating laryngeal mucosal metaplasia from respiratory columnar mucosa (with goblet cells) to squamous mucosa deficient of goblet cells. The latter may represent a compensatory defensive mechanism against the reflux damage 
by adding dead cell top layers to the laryngeal mucosa and hence increasing its resistance to the insult}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid12018979\charrsid726654  from}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 
 reflux when some of the protective mucin genes are down regulated. Furthermore, mucin gene expression can be switched from secretory, gel forming mucin genes (e.g. MUC2, 5AC, 5B) expressed by respiratory mucosa to membrane bound mucin genes (e.g. }{
\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid10028969\charrsid726654 MUC}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 
1, 3, 4) expressed by squamous mucosa, although the latter also expresses secretory mucin genes at a much lower level. The result would be an altered qua
ntity and/or quality of laryngeal mucus which could affect its barrier functions. This can result in deleterious effects with possible aggravation of patients\rquote  symptoms as well as local laryngeal mucosal changes.   
\par }\pard \ltrpar\ql \li0\ri0\sb120\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid9854660 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 Although it has been reported that LPR }{\rtlch\fcs1 
\ab\af0 \ltrch\fcs0 \insrsid3938721\charrsid726654 alters}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 
 laryngeal mucin gene expression, the potential impact of reflux severity on laryngeal mucin gene expression has received little attention. }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7406326\charrsid726654 Belafsky et al}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid11871710\charrsid726654  [5, 6]}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7406326\charrsid726654  developed }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid12389619\charrsid726654 Reflux Symptom Index (RSI) and }{\rtlch\fcs1 
\af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 reflux finding score (RFS) to assess patients\rquote  reflux related symptoms and laryngoscopic mucosal change}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7424389\charrsid726654 s}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid12389619\charrsid726654  noted by laryngologists respectively.  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid423519\charrsid726654 RSI is a nine-item self-administered outcome questionnaire designed to document LPR symptom severity. }{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid4343130\charrsid726654 Patients are asked to rate how nine problems have affected
 them over the past month on a scale of 0 (no reflux symptoms) to 5 (severe reflux symptoms), with a maximum total score of 45. RFS is an eight-item index designed to }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12340470\charrsid726654 evaluate }{\rtlch\fcs1 
\af0 \ltrch\fcs0 \insrsid4343130\charrsid726654 severity of reflux based on laryngoscopic findings assessed by the attending laryngologist and scores range from 0 (normal laryngeal mucosa) to 26 (most severe reflux laryngitis)}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \super\insrsid4343130\charrsid726654 6}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid4343130\charrsid726654 . }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 RSI }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang1033\langfe2057\langnp1033\insrsid12389619\charrsid726654 >13 and RFS >7 have been considered to indicate LPR reflux}{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid11871710\charrsid726654  [3]}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid12389619\charrsid726654 .}{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid12389619\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid7406326\charrsid726654 
\par }\pard \ltrpar\ql \li0\ri0\sb120\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid9907672 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid7406326\charrsid726654 Th}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 
\insrsid12926898\charrsid726654 e primary }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid7406326\charrsid726654 aim}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid12926898\charrsid726654  of this study is }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 
\insrsid7406326\charrsid726654 to investigate whether the alteration of laryngeal mucin gene expression depends on the severity of LPR as }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7406326\charrsid726654 determined by RSI and RFS. }{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid12389619\charrsid726654 The best characterized mucin genes so far, }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid10028969\charrsid726654 MUC}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 1-4, 5AC, 5B, 6 and 7}{\rtlch\fcs1 
\af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 , were involved in the study. }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6834369\charrsid726654 MUCs2, 5AC, 5B and 6 are secreted gel-forming }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1408669\charrsid726654 
(polymeric) }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6834369\charrsid726654 mucins while MUCs1, 3 and 4 are membrane bound. MUC7 is a secreted but not}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7424389\charrsid726654  a}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid6834369\charrsid726654  gel-forming mucin as it }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \insrsid6834369\charrsid726654 exists as a monomer}{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \super\insrsid1408669\charrsid726654 3}{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 
\insrsid1408669\charrsid726654 .}{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \insrsid7239313\charrsid726654  }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \insrsid12926898\charrsid726654 Secondary }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \insrsid7239313\charrsid726654 
aims of the study include the }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7604819\charrsid726654 post treatment changes of RSI and RFS and the }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7239313\charrsid726654 correlation between RSI and RFS}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid11539721\charrsid726654 .}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3559321\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 
\par }\pard \ltrpar\ql \li0\ri0\sb120\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid12389619 {\rtlch\fcs1 \af0 \ltrch\fcs0 \b\insrsid12389619\charrsid726654 Methods
\par }\pard \ltrpar\ql \li0\ri0\sb120\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid10630584 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 
Laryngeal mucosal samples from patients were obtained following the approval of the local ethics committee. These included 33 patients suffering from reflux symptoms not }{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid684588\charrsid684588 adequately}{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid684588  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 responding to treatment with acid suppression therapy (AST) for at least 6 
months and who required surgical intervention to treat laryngeal mucosal changes }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid2625698\charrsid726654 such as vocal cord polyps}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3683256\charrsid726654 /nodules}{\rtlch\fcs1 
\af0 \ltrch\fcs0 \insrsid2625698\charrsid726654 , }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 or to take laryngeal mucosal biopsies to get a definite pathological diagnosis. }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\cf6\insrsid407057\charrsid684588 Exclusion criteria included: no other causes of chronic laryngitis such as smoking, chest disease. }{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid16539757\charrsid684588 All patients were either non}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \cf6\insrsid10630584 -}{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid16539757\charrsid684588  or ex}{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid10630584 -}{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid16539757\charrsid684588 smokers, the latest ex}{
\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid10630584 -}{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid16539757\charrsid684588 smoker was for 15 ye}{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid16539757\charrsid12584094 ars.}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\cf6\insrsid12389619\charrsid12584094 
\par }\pard \ltrpar\ql \li0\ri0\sb120\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid4141760 {\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid3941763\charrsid12584094 Patients were requested to fill an RSI }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid12584094\charrsid12584094 sheet }{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid15742734\charrsid12584094 by}{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid3941763\charrsid12584094  rat}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\cf6\insrsid15742734\charrsid12584094 ing}{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid3941763\charrsid12584094  how nine }{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid15742734\charrsid12584094 symptoms }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\cf6\insrsid3941763\charrsid12584094 have affected them over the past month on a scale of 0 (no reflux symptoms) to 5 (severe reflux symptoms), with a maximum total score of 45. RFS }{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid3491439\charrsid12584094 
was determined by the attending }{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid5311336\charrsid12584094 laryngologist rating }{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid3941763\charrsid12584094 eight-}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\cf6\insrsid5311336\charrsid12584094 laryngoscopic }{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid9725788\charrsid12584094 mucosal changes. These were }{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid13074004\charrsid12584094 scored 0 }{\rtlch\fcs1 \af0 
\ltrch\fcs0 \cf6\insrsid1594683\charrsid12584094 (normal laryngeal mucosa) }{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid12584094\charrsid12584094 to}{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid13074004\charrsid12584094  2 or 4}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\cf6\insrsid1594683\charrsid12584094  (most severe reflux laryngitis)}{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid13074004\charrsid12584094  with a maximum }{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid9725788\charrsid12584094 score of 26}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \cf6\insrsid1594683\charrsid12584094 . }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid12389619\charrsid726654 RSI and RFS were determined a}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 
t the time of initial clinical consultation and immediately prior to surgery when laryngeal mucosal biopsies were taken. In the interim time, patients were subjected to AST, usually including a proton pump inhibitor (PPI) and advised on life style measure
s to try and alleviate reflux.}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6647862\charrsid726654  The}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12389619\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6647862\charrsid726654 m}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid12389619\charrsid726654 ean reduction in reflux symptoms and signs as a result of medical treatment was evaluated. }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14882425\charrsid726654 S}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 
cores }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid12389619\charrsid726654 >13 for }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 RSI }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang1033\langfe2057\langnp1033\insrsid12389619\charrsid726654 and >7 for }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 RFS }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14882425\charrsid726654 were considered }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid12389619\charrsid726654 to divide the main patient }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14882425\charrsid726654 cohort }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 into }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid14617684\charrsid726654 4}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12389619\charrsid726654  groups: low RSI (0-13) and high RSI (14
-45) groups and low RFS (0-7) and high RFS (8-26) groups. Mucosal samples were taken from the vocal cords, laryngeal ventricles and posterior commissure as these are the areas often involved in laryngeal disorders. }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 
\insrsid12389619\charrsid726654 Histological analysis was carried out to determine the nature of laryngeal mucosa. }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 Mucin gene expression in }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid8847558\charrsid726654 control}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 
 laryngeal mucosa was studied in samples taken from 2 patients with no documented reflux symptoms or signs and no history of anti reflux medication. These were 84y old female and 87y old male and samples were purchased from the NHS tissue bank (
{\*\xmlopen\xmlns2{\factoidname City}}{\*\xmlopen\xmlns2{\factoidname City}}Peterborough{\*\xmlclose}, {\*\xmlopen\xmlns2{\factoidname City}}UK{\*\xmlclose}{\*\xmlclose}).
\par }\pard \ltrpar\ql \li0\ri0\sb120\sl480\slmult1\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid9600825 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9600825\charrsid726654 In situ hybridisation }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 
was}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9600825\charrsid726654  employed to}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12389619\charrsid726654  stud}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9600825\charrsid726654 y }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid12389619\charrsid726654 the distribution and pattern of mucin gene expression in laryngeal mucosa. We used digoxigenin-labelled 48 bas
e-pair sequence oligonucleotide probes complimentary to the most frequently occurring base-pair sequences within the mucin }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6303292\charrsid726654 messenger RNA (}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid12389619\charrsid726654 mRNA}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6303292\charrsid726654 )}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 
 to obtain signal amplification by hybridizing the largest number of probes with the same mRNA molecule.
\par }\pard \ltrpar\ql \li0\ri0\sb120\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid9765090 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 Th}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid6647862\charrsid726654 is}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12389619\charrsid726654   methodology is described in detail elsewhere}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11871710\charrsid726654  [7, 8]}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid12389619\charrsid726654 . Positive and negative controls were used to confirm the specificity of the in situ hybridization results. Scoring was carried out on a 0 (no mucin gene expression) or 1 (mucin gene expression) basis with t
he use of internal positive and negative controls. 
\par }\pard \ltrpar\qj \li0\ri0\sb120\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid5535581 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid10230623\charrsid726654 Statistical analysis: }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid3951852\charrsid726654 Data }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5918930\charrsid726654 are}{\rtlch\fcs1 \af39 \ltrch\fcs0 \f39\insrsid8683296\charrsid726654  expressed as means }{\ltrch\fcs1 \rtlch\fcs0 
\f0\fs24\lang1025\insrsid8683296\charrsid726654 {\field{\*\fldinst SYMBOL 177 \\f "Courier New" \\s 12}{\fldrslt\f2\fs24}}}{\rtlch\fcs1 \af39 \ltrch\fcs0 \f39\insrsid8683296\charrsid726654   standard error of the mean }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 
\i\insrsid10108827\charrsid726654 (SEM)}{\rtlch\fcs1 \ab\ai\af0 \ltrch\fcs0 \b\i\insrsid3951852\charrsid726654 .}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3951852\charrsid726654  T}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\chshdng0\chcfpat0\chcbpat8\insrsid12389619\charrsid726654 he correlation between preoperative RSI and RFS was analysed using Pearson's correlation coefficient}{\rtlch\fcs1 \af0 \ltrch\fcs0 \chshdng0\chcfpat0\chcbpat8\insrsid1343037\charrsid726654  (}{
\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid1343037\charrsid726654 r}{\rtlch\fcs1 \af0 \ltrch\fcs0 \chshdng0\chcfpat0\chcbpat8\insrsid1343037\charrsid726654 )}{\rtlch\fcs1 \af0 \ltrch\fcs0 \chshdng0\chcfpat0\chcbpat8\insrsid12389619\charrsid726654 . }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 The n}{\rtlch\fcs1 \af0\afs23 \ltrch\fcs0 \fs23\insrsid12389619\charrsid726654 onparametric test }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid12389619\charrsid726654 
{\*\xmlopen\xmlns2{\factoidname City}}{\*\xmlopen\xmlns2{\factoidname City}}{\*\xmlopen\xmlns2{\factoidname City}}Chi}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12389619\charrsid726654  Square{\*\xmlclose}{\*\xmlclose}{\*\xmlclose} }{\rtlch\fcs1 \af0\afs23 
\ltrch\fcs0 \fs23\insrsid12389619\charrsid726654 was used to }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 analyse the }{\rtlch\fcs1 \af0\afs23 \ltrch\fcs0 \fs23\insrsid12389619\charrsid726654 r}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid12389619\charrsid726654 esults and }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid12389619\charrsid726654 p}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12389619\charrsid726654 <0.05 was considered significant. }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid10554264\charrsid726654 
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid6634537 {\rtlch\fcs1 \af0 \ltrch\fcs0 \b\insrsid9469842\charrsid726654 Results}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\b\insrsid16659327\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \b\insrsid1579750\charrsid726654 
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid4533408 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11539721\charrsid726654 Table I illustrates the }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid3617891\charrsid726654 numbers of }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11539721\charrsid726654 patients }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3617891\charrsid726654 included }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid4533408\charrsid726654 
to achieve the aims of}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3617891\charrsid726654  the study}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid4533408\charrsid726654 . }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13633416\charrsid726654 The study }{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid4533408\charrsid726654 population }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13633416\charrsid726654 included 33 patients}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid405680\charrsid726654  (}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid13633416\charrsid726654 20 males and 13 females}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid405680\charrsid726654 ), with}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16065509\charrsid726654  an age range from 27 to 81y (53}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid9117803\charrsid726654  }{\ltrch\fcs1 \rtlch\fcs0 \f0\fs24\lang1025\insrsid9117803\charrsid726654 {\field{\*\fldinst SYMBOL 177 \\f "Courier New" \\s 12}{\fldrslt\f2\fs24}}}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9117803\charrsid726654  }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16065509\charrsid726654 2.2y). }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13633416\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid4929823\charrsid726654 The}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid13969245\charrsid726654  RSI varied from 1 to 39}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6569206\charrsid726654  (19}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9117803\charrsid726654  }{\ltrch\fcs1 \rtlch\fcs0 
\f0\fs24\lang1025\insrsid9117803\charrsid726654 {\field{\*\fldinst SYMBOL 177 \\f "Courier New" \\s 12}{\fldrslt\f2\fs24}}}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9117803\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6839680\charrsid726654 1}{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1990168\charrsid726654 .}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6839680\charrsid726654 75}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6569206\charrsid726654 )}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid4929823\charrsid726654 , and
}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13969245\charrsid726654  RFS ranged from 2 to 22}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6569206\charrsid726654  (12}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9117803\charrsid726654  }{\ltrch\fcs1 \rtlch\fcs0 
\f0\fs24\lang1025\insrsid9117803\charrsid726654 {\field{\*\fldinst SYMBOL 177 \\f "Courier New" \\s 12}{\fldrslt\f2\fs24}}}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9117803\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1997648\charrsid726654 0}{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid8528752\charrsid726654 .}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1997648\charrsid726654 9}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6569206\charrsid726654 )}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid4929823\charrsid726654 . }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid69025\charrsid726654 There was no correlation between patients\rquote  age and RSI (}{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid3173385\charrsid726654 r}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3173385\charrsid726654  =}{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11093910\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid69025\charrsid726654 -0.098) or RFS (}{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid11093910\charrsid726654 r}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid11093910\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3173385\charrsid726654 = }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid69025\charrsid726654 0.086).
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid8133039 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1649164\charrsid726654 Fifteen }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid9469842\charrsid726654 patients (7 males and 8 females}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13316217\charrsid726654 , }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6250139\charrsid726654 mean }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid13316217\charrsid726654 age 50}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15475155\charrsid726654 .6y}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12613774\charrsid726654 , }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid15233958\charrsid726654 +/-}{\rtlch\fcs1 
\af0 \ltrch\fcs0 \insrsid6250139\charrsid726654  3.7y}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9469842\charrsid726654 ) }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1649164\charrsid726654 had }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9469842\charrsid726654 
scores available for both pre and post medical treatment}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6250139\charrsid726654  RSI and RFS}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1649164\charrsid726654 . }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid14812408\charrsid726654 T}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9469842\charrsid726654 he mean reduction in }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1453546\charrsid726654 RSI }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6250139\charrsid726654 after }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5570857\charrsid726654 AST }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9469842\charrsid726654 was 2.5 whereas mean }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1453546\charrsid726654 improvement of RFS wa}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid9469842\charrsid726654 s 0.4. }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7109382\charrsid726654 Dividing the mean improvement by the mean patients pre treatment score, t}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9469842\charrsid726654 his }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7109382\charrsid726654 resulted in }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13129784\charrsid726654 14}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9469842\charrsid726654 % improvement in RSI }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid13129784\charrsid726654 and only 3}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9469842\charrsid726654 % improvement in RFS.}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16065509\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7234773\charrsid726654 
Only p}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid206890\charrsid726654 ost }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5570857\charrsid726654 medical }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid206890\charrsid726654 treatment (preope}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid535648\charrsid726654 rat}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid206890\charrsid726654 ive) RSI and RFS }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15932016\charrsid726654 data }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid206890\charrsid726654 were available 
}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7175056\charrsid726654 in further}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid206890\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid2497393\charrsid726654 1}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid6891135\charrsid726654 2}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid2497393\charrsid726654  patients. }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7149603\charrsid726654 Thus, preoperative RSI and RFS were available in 2}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid6891135\charrsid726654 7}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7149603\charrsid726654  patients}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15932016\charrsid726654 . The}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid10163085\charrsid726654 re was no }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15932016\charrsid726654 correlation between preoperative RSI and RFS (}{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid3173385\charrsid726654 r}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3173385\charrsid726654  = }{\rtlch\fcs1 
\af0 \ltrch\fcs0 \insrsid15932016\charrsid726654 0.3, }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid15932016\charrsid726654 P}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15932016\charrsid726654 >0.13).}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7149603\charrsid726654 
 }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7492508\charrsid726654 
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid69025 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid8782425\charrsid726654 For the analysis of mucin gene expression}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid11682737\charrsid726654 , RSI and RFS data were available for a total of 31 and 29 patients respectively, Table 1.}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14035945\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid656846\charrsid726654 Th}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid2253172\charrsid726654 ese }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid656846\charrsid726654 w}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid2253172\charrsid726654 ere}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid656846\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid2253172\charrsid726654 the }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11210743\charrsid726654 patient }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid2710461\charrsid726654 cohorts }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid656846\charrsid726654 divided into low and high RSI and RFS}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid4658510\charrsid726654  groups}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid656846\charrsid726654 .}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid863661\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid656846\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid8349745\charrsid726654 
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid5255206 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3479280\charrsid726654 In }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5255206 control}{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3479280\charrsid726654  laryngeal mucosa,}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid2695680\charrsid726654  t}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3485577\charrsid726654 
he most prevalent mucin gene was MUC4 expressed in 8}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6179711\charrsid726654 2}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3485577\charrsid726654 % of samples followed by }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid10028969\charrsid726654 MUC}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3485577\charrsid726654 3 and 5AC (63% each). }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid10028969\charrsid726654 MUC}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3485577\charrsid726654 
1 and 2 were less prevalent (7% each)}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid10321301\charrsid726654 , }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3485577\charrsid726654 Table }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6686106\charrsid726654 2}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid3485577\charrsid726654 . Secretory mucin genes }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid10028969\charrsid726654 MUC}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3485577\charrsid726654 2 and 5AC were expressed only in respiratory mucosa}{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid2492586\charrsid726654  whereas membrane bound mucin genes }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid10028969\charrsid726654 MUC}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3212211\charrsid726654 1, 3 }{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid3485577\charrsid726654 and }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3212211\charrsid726654 4}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3485577\charrsid726654  were expressed in both mucosal types.  }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid6830376\charrsid726654 MUC5B was excluded from the analysis because }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid8279178\charrsid726654 the }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6830376\charrsid726654 positive control tissue}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid3608801\charrsid726654  (tracheal mucosa)}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6830376\charrsid726654  consistently }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid8279178\charrsid726654 failed to show mucin expression. }{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid10028969\charrsid726654 MUC}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12401342\charrsid726654 6 and 7 }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6179711\charrsid726654 were not }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12401342\charrsid726654 
express}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6179711\charrsid726654 ed }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12401342\charrsid726654 in }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5255206 control}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12401342\charrsid726654 
 laryngeal mucosa or in }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7020982\charrsid726654 patients}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid10431429\charrsid726654 \rquote }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7020982\charrsid726654  laryngeal }{\rtlch\fcs1 
\af0 \ltrch\fcs0 \insrsid12401342\charrsid726654 mucosa}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12875155\charrsid726654 .}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid8551291\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12401342\charrsid726654 
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid5127876 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid3479280\charrsid726654 Laryngeal mucin gene expression and }{\rtlch\fcs1 \ab\af0 
\ltrch\fcs0 \b\insrsid15476593\charrsid726654 RSI}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid15664842\charrsid726654  }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid15476593\charrsid726654 
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid1853480 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6179711\charrsid726654 Applying }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid1928212\charrsid726654 the cut off scores of }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6179711\charrsid726654 Belafsky et al}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1928212\charrsid726654 , l}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid13188857\charrsid726654 ow and high RSI groups in}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1928212\charrsid726654 cluded }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13188857\charrsid726654 12 and 19 patients respectively. }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid7550738\charrsid726654 Laryngeal mucosa from p}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid356919\charrsid726654 atients with low RSI }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9469842\charrsid726654 showed significant down regulation of }{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid10028969\charrsid726654 MUC}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid539298\charrsid726654 3 (}{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid539298\charrsid726654 p}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid539298\charrsid726654 <0.001), 4 (}{
\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid6639123\charrsid726654 p}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6639123\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid539298\charrsid726654 <0.01) and 5AC (}{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 
\i\insrsid6639123\charrsid726654 p}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6639123\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid539298\charrsid726654 <0.001)}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11762252\charrsid726654  gene expression }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid539298\charrsid726654 compared to }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7940057\charrsid726654 control}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid356919\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid8324964\charrsid726654 laryngeal }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid356919\charrsid726654 mucosa}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9469842\charrsid726654 . }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7167210\charrsid726654 With }{\rtlch\fcs1 
\af0 \ltrch\fcs0 \insrsid7940057\charrsid726654 high }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7167210\charrsid726654 RSI, }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid10028969\charrsid726654 MUC}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7167210\charrsid726654 
3 and 4 }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16065509\charrsid726654 were up regulated}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7940057\charrsid726654 ,}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16065509\charrsid726654  although their expression}{\rtlch\fcs1 
\af0 \ltrch\fcs0 \insrsid16391766\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7167210\charrsid726654 did not reach }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5255206 cotrol}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7167210\charrsid726654  levels}{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid4663309\charrsid726654 . }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16318783\charrsid726654 However, t}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid471374\charrsid726654 his resulted in }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid16318783\charrsid726654 significantly }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid471374\charrsid726654 higher }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid10028969\charrsid726654 MUC}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid471374\charrsid726654 3 }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6370107\charrsid726654 (}{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid6639123\charrsid726654 p}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6639123\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6370107\charrsid726654 
<0.001) }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid471374\charrsid726654 and 4}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6370107\charrsid726654  (}{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid6639123\charrsid726654 p}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid6639123\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6370107\charrsid726654 <0.02)}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid471374\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6370107\charrsid726654 g}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid471374\charrsid726654 ene expression in high RSI compared to low RSI mucosa. }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid10450079\charrsid726654 MUC5AC }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3608801\charrsid726654 remained }{\rtlch\fcs1 
\af0 \ltrch\fcs0 \insrsid10450079\charrsid726654 significa}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16319665\charrsid726654 ntly down regulated (}{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid6639123\charrsid726654 p}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid6639123\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16319665\charrsid726654 <0.001)}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5057786\charrsid726654  in high RSI mucosa similar to low RSI mucosa}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid16319665\charrsid726654 . }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid10028969\charrsid726654 MUC}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid333331\charrsid726654 1 and 2 }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11101670\charrsid726654 
showed no significant difference between the }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9337270\charrsid726654 2 groups and }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7940057\charrsid726654 control}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9337270\charrsid726654 
 mucosa or between the }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11101670\charrsid726654 low and high RSI groups}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid4283395\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5660234\charrsid726654 (Figure 1)}{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11101670\charrsid726654 . 
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid5255206 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16661881\charrsid726654 As squamous metaplasia was noted in reflux mucosa, }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9469842\charrsid726654 squamous mucosal samples }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16661881\charrsid726654 were excluded }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9469842\charrsid726654 from the analysis}{\rtlch\fcs1 
\af0 \ltrch\fcs0 \insrsid16661881\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid10487264\charrsid726654 of MUC5AC expression. }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11874811\charrsid726654 T}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid9469842\charrsid726654 here was still significant down regulation of MUC5AC in }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12013377\charrsid726654 low and high RSI }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9469842\charrsid726654 group samples compared to 
}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5255206 control}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid8486138\charrsid726654  laryngeal mucosa}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15815313\charrsid726654  (results not shown)}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid9469842\charrsid726654 .}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12013377\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12001607\charrsid726654 
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid5127876 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid6830376\charrsid726654 Laryngeal mucin gene expression and RFS
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid6578772 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13188857\charrsid726654 Low and high RFS groups included 2 and 2}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid862565\charrsid726654 7}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13188857\charrsid726654  patients respectively}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5779900\charrsid726654 
, and because only 2 patients were in the low RFS group, we did not consider this group in the gene expression analysis. In the high}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1853675\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid11886571\charrsid726654 RFS}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5779900\charrsid726654  group}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11886571\charrsid726654 , MUC3 and 4}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid10838844\charrsid726654  expression }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5779900\charrsid726654 was similar to that noted in the }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid10838844\charrsid726654 high RSI mucosa}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7940057\charrsid726654 .}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid10838844\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11886571\charrsid726654 MUC5AC }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6560032\charrsid726654 was significantly }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid11886571\charrsid726654 down regulat}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6560032\charrsid726654 ed in high RFS }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9857131\charrsid726654 compared to }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid7940057\charrsid726654 control}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9857131\charrsid726654  mucosa}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11886571\charrsid726654  (}{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid11886571\charrsid726654 p}{\rtlch\fcs1 
\af0 \ltrch\fcs0 \insrsid11886571\charrsid726654 <0.001). }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5775769\charrsid726654 
Further analysis of MUC5AC expression with the exclusion of squamous mucosa, showed no change in observed expression pattern with high RFS mucosa expressing MUC5AC at a significantly lower level than }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid7940057\charrsid726654 control}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13706749\charrsid726654  laryngeal mucosa}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5775769\charrsid726654 .}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid4087118\charrsid726654  }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5060282\charrsid726654 
\par }\pard \ltrpar\qj \li0\ri0\sb120\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid14443529 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid657507\charrsid726654 
Combined high and low score groups were obtained by adding the high RSI and RFS together and the low RSI and RFS added together according to }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid8016737\charrsid726654 the cut off scores of }{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid657507\charrsid726654 Belafsky et al\rquote s }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15623646\charrsid726654 a}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid657507\charrsid726654 nd laryngeal mucin gene expression was analysed in these }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16065509\charrsid726654 2 }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12323260\charrsid726654 groups}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid657507\charrsid726654 . In }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid7940057\charrsid726654 the }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid657507\charrsid726654 combined low score group there was significant down regulation of MUC3 (}{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid9781956\charrsid726654 p}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid9781956\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid657507\charrsid726654 <0.001)}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11622728\charrsid726654 ,}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6317754\charrsid726654  }{\rtlch\fcs1 
\af0 \ltrch\fcs0 \insrsid11622728\charrsid726654 MUC4 (}{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid11622728\charrsid726654 p}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11622728\charrsid726654  <0.02) }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid657507\charrsid726654 and MUC5AC (}{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid9781956\charrsid726654 p}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9781956\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid657507\charrsid726654 
<0.001) gene expression}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12323260\charrsid726654  compared to }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid10175818\charrsid726654 control}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid657507\charrsid726654 . With}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid10175818\charrsid726654  the}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid657507\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid10175818\charrsid726654 high}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid657507\charrsid726654 
 combined score, MUC3 and 4 }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12263606\charrsid726654 were }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid657507\charrsid726654 up regulat}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12263606\charrsid726654 ed. A}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid657507\charrsid726654 lthough expression levels did not reach }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid10175818\charrsid726654 control}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid657507\charrsid726654  levels}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid12263606\charrsid726654 , }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid657507\charrsid726654 MUC}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12263606\charrsid726654 3 and }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid657507\charrsid726654 
4 expression was significantly higher than that in combined low score group (}{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid657507\charrsid726654 p}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid657507\charrsid726654 
<0.01). MUC5AC expression continues to be significantly down regulated (p<0.001) in combined high score group}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16146695\charrsid726654 , Figure 2}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid657507\charrsid726654 . }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid10028969\charrsid726654 MUC}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid657507\charrsid726654 1 and 2 expression was not significantly altered in either combined score group.}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 
\b\insrsid10374962\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5535581\charrsid726654 As multiple comparisons have been made between mucin gene 
expression data and RSF/RSI, we made a Bonferroni correction which assumes complete independence between comparisons. This indicated our original level of significance should be changed from 0.05 to 0.013.}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid14443529\charrsid726654  The significant results are not altered apart from the MUC 4 data which had }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid14443529\charrsid726654 p}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14443529\charrsid726654 
 values of 0.02.
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid5127876 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid9469842\charrsid726654 Discussion
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid2322695 {\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid1531026\charrsid726654 Although the RSI and RFS are }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid14031101\charrsid726654 used }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid1531026\charrsid726654 for diagnosing}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang1033\langfe2057\langnp1033\insrsid16003194\charrsid726654  and quantifying}{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid1531026\charrsid726654  the same condition by patients\rquote  symptoms and physical laryngeal findings, t
}{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid13528865\charrsid726654 he correlation between }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid10435092\charrsid726654 these 2 scoring systems }{\rtlch\fcs1 \af0 
\ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid13528865\charrsid726654 had }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid7364932\charrsid726654 not always been strong. }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang1033\langfe2057\langnp1033\insrsid460299\charrsid726654 Mesallam et al}{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid11871710\charrsid726654  [9]}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang1033\langfe2057\langnp1033\insrsid460299\charrsid726654  reported }{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid8738363\charrsid726654 
 HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed?term=Mesallam%20TA%5BAuthor%5D&cauthor=true&cauthor_uid=17672246" }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13569473\charrsid726654 {\*\datafield 
00d0c9ea79f9bace118c8200aa004ba90b0200000003000000e0c9ea79f9bace118c8200aa004ba90be000000068007400740070003a002f002f007700770077002e006e006300620069002e006e006c006d002e006e00690068002e0067006f0076002f007000750062006d00650064003f007400650072006d003d004d00
6500730061006c006c0061006d002500320030005400410025003500420041007500740068006f0072002500350044002600630061007500740068006f0072003d0074007200750065002600630061007500740068006f0072005f007500690064003d00310037003600370032003200340036000000795881f43b1d7f48af
2c825dc485276300000000a5ab00000000000000000000000000000000000000000000000000000000000000000000000000000000000000}}}{\fldrslt {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid8738363\charrsid726654 a }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9843178\charrsid726654 
strong }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid8738363\charrsid726654 correlation between the RFS and the RSI}{\rtlch\fcs1 \af0 \ltrch\fcs0 \cs21\insrsid8738363\charrsid726654  whereas }{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0 \ltrch\fcs0 
\cs26\lang9\langfe2057\langnp9\insrsid11361116\charrsid726654  HYPERLINK "http://oto.sagepub.com/search?author1=Kristin+K.+Marcum&sortspec=date&submit=Submit" }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang9\langfe2057\langnp9\insrsid13569473\charrsid726654 
{\*\datafield 
00d0c9ea79f9bace118c8200aa004ba90b0200000003000000e0c9ea79f9bace118c8200aa004ba90bc000000068007400740070003a002f002f006f0074006f002e0073006100670065007000750062002e0063006f006d002f007300650061007200630068003f0061007500740068006f00720031003d004b0072006900
7300740069006e002b004b002e002b004d0061007200630075006d00260073006f007200740073007000650063003d00640061007400650026007300750062006d00690074003d005300750062006d00690074000000795881f43b1d7f48af2c825dc485276300000000a5ab00000000000000000000000000000000000000
ff0000000000000000000000000000000000000000000000}}}{\fldrslt {\rtlch\fcs1 \af0 \ltrch\fcs0 \cs20\lang9\langfe2057\langnp9\insrsid11361116\charrsid726654 Marcum}}}\sectd \ltrsect
\pgnrestart\linex0\headery709\footery709\colsx708\endnhere\sectlinegrid360\sectdefaultcl\sectrsid3811107\sftnbj {\rtlch\fcs1 \af0 \ltrch\fcs0 \cs27\lang9\langfe2057\langnp9\insrsid11361116\charrsid726654  et al}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\cs27\lang9\langfe2057\langnp9\insrsid11871710\charrsid726654  [10]}{\rtlch\fcs1 \af0 \ltrch\fcs0 \cs27\lang9\langfe2057\langnp9\insrsid11361116\charrsid726654  reported that}}}\sectd \ltrsect
\pgnrestart\linex0\headery709\footery709\colsx708\endnhere\sectlinegrid360\sectdefaultcl\sectrsid3811107\sftnbj {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid460299\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang9\langfe2057\langnp9\insrsid460299\charrsid726654 RSI cannot accurately predict a subject\rquote s RFS. }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang9\langfe2057\langnp9\insrsid11696721\charrsid726654 Furthermore, }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang9\langfe2057\langnp9\insrsid9644300\charrsid726654 it has been reported }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid8602426\charrsid726654 that }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7222475\charrsid726654 in patients treated with PPI, }{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid8602426\charrsid726654 the }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5310208\charrsid726654 resolution of }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid8602426\charrsid726654 physical findings of LPR }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid5310208\charrsid726654 lags behind that of }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14356468\charrsid726654 reflux }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid8602426\charrsid726654 symptoms}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11871710\charrsid726654 
 [11, 12]}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5310208\charrsid726654 .}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid8602426\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5310208\charrsid726654 T}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid8602426\charrsid726654 his impl}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6296834\charrsid726654 ies}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid8602426\charrsid726654  that the }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14356468\charrsid726654 severity of }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid8602426\charrsid726654 physical findings of LPR }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16003194\charrsid726654 might}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5310208\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid8602426\charrsid726654 not always }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14356468\charrsid726654 parallel }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid8602426\charrsid726654 patient}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5310208\charrsid726654 s\rquote }
{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid8602426\charrsid726654  symptoms.}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11696721\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9644300\charrsid726654 This is also noted in }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid12190033\charrsid726654 this study}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9644300\charrsid726654  as the }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12190033\charrsid726654 a}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9469842\charrsid726654 
verage reduction in reflux }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13264704\charrsid726654 findings was much less than the reduction of reflux symptoms. }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11162141\charrsid726654 
No more information was collected on the type, dosage and duration of PPI treatment as this was not th}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16065509\charrsid726654 e}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11162141\charrsid726654  main aim of the study.}{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9469842\charrsid726654 
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid5255206 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3948774\charrsid726654 The analysis of }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid3422491\charrsid726654 m}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3948774\charrsid726654 ucin gene expression }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid4813192\charrsid726654 with}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3948774\charrsid726654 
 RSI and RFS shows similar patterns in the 2 patients\rquote  groups distinctive from the }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5255206 control}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3948774\charrsid726654  expression patterns. In}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid10175818\charrsid726654  the }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3948774\charrsid726654 
low RSI and RFS groups, the 3 main mucin genes (2 membrane bound MUC3 and 4 and one secretory MUC5AC) were down regulated. This was significant for the 3 mucin genes in the low RSI group}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid4813192\charrsid726654 .}{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3948774\charrsid726654  With }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid10175818\charrsid726654 high}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3948774\charrsid726654  RSI, }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid16065509\charrsid726654 the expression of the 2 membrane bound mucin genes became up regulated from their low expression levels}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3948774\charrsid726654 . In the high RSI group, }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid10028969\charrsid726654 MUC}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3948774\charrsid726654 3 and 4 expression was stronger than in the high RFS group and it approached the }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5255206 control}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid3948774\charrsid726654  levels and became significantly higher than }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16065509\charrsid726654 that in }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3948774\charrsid726654 low RSI group. In the 2 high scor}
{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid10175818\charrsid726654 ing}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3948774\charrsid726654 
 groups, the down regulation of the secretory mucin gene (MUC5AC) was maintained. It is possible that exposure of laryngeal mucosa to mild reflux initially inhibits (down regulates) the 
expression of membrane bound and secretory mucin genes and with increased reflux severity, mucosal insult stimulates the expression of only the membrane bound genes which seem to recover from the inhibitory effect of mild reflux and regain a near }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5255206 co}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3948774\charrsid726654 n}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5255206 t}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3948774\charrsid726654 r}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid5255206 o}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3948774\charrsid726654 l expression. }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid10175818\charrsid726654 S}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3948774\charrsid726654 
evere reflux continues to inhibit (down regulate) the major airway secretory mucin gene MUC5AC which fails to recover its }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5255206 control}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3948774\charrsid726654 
 expression and continues at significantly low expression levels. This could be related to increased mucosal inflammation}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11871710\charrsid726654  [13, 14}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\super\insrsid2522828\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12086812\charrsid726654 leading to}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3948774\charrsid726654  differential effect}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid10706075\charrsid726654 s}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3948774\charrsid726654 
 on membrane and secretory mucin gene expression. The exact mechanism and biological importance of this differential alteration of mucin expression with increased severity of reflux symptoms needs further study.  }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\super\insrsid3422491\charrsid726654 
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid5127876 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3422491\charrsid726654 Squamous metaplasia was noted in }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid10175818\charrsid726654 the}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3422491\charrsid726654 
 posterior commissure, ventriclular and vocal cord mucosa. As MUC5AC is only expressed in respiratory laryngeal mucosa, squamous metaplasia was expected to contribute to reduced MUC5AC expression. Therefore, squamous
 mucosal samples were excluded from the analysis to }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7497512\charrsid726654 determine if}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3422491\charrsid726654 
 down regulation of MUC5AC was due merely to squamous metaplasia and reduced MUC5AC-e}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12086812\charrsid726654 x}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3422491\charrsid726654 
pressing respiratory mucosa or due to a genuine alteration of expression in laryngeal mucosa. }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7497512\charrsid726654  The}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3422491\charrsid726654  MUC5AC}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid7497512\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15623646\charrsid726654 gene was}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3422491\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid10706075\charrsid726654 still }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3422491\charrsid726654 
significantly down regulated in the respiratory mucosa regardless of the severity of reflux symptoms and signs. This suggests a direct inhibition of LPR on laryngeal MUC5AC gene expression independent of mucosal metaplasia. 
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid1773977 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3422491\charrsid726654 The near complet
e recovery of MUC3 and 4 expression in severe reflux and the irreversible MUC5AC down regulation independent of the reactive/regenerative laryngeal mucosa changes implies that MUC5AC could be a major determinant factor involved in the development of reflu
x-related laryngeal symptoms and mucosal changes. }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12086812\charrsid726654 
The MUC5AC gene product is a secreted gel forming mucin and the lack of MUC5AC expression may indicate that the underlying laryngeal mucosa would be unprotected/poorly protected and exposed to the damaging effects of reflux. }{\rtlch\fcs1 \af0 
\ltrch\fcs0 \cf6\insrsid12941471\charrsid2111389 This might explain some of the symptoms of LPR }{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid1847690\charrsid2111389 which }{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid282711\charrsid2111389 
take a continuous or more recurrent course although LPR itself occurs in episodes. These include}{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid12941471\charrsid2111389  throat irritation and frequent throat clearing}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\cf6\insrsid1847690\charrsid2111389 , repeated cough}{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid10905576\charrsid2111389  and}{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid1847690\charrsid2111389  }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\cf6\insrsid10905576\charrsid2111389 difficult swallowing. }{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid5833868\charrsid2111389 It could be involved in the development of }{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf6\insrsid1773977\charrsid2111389 laryngeal oedema.}{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1773977  It }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3422491\charrsid726654 
could also contribute to the slower improvement of endoscopic laryngeal mucosal changes (RFS) with acid suppression therapy compared to the improvement of patients\rquote  symptoms (RSI). 
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid5127876 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3948774\charrsid726654 The numbers of patients in the RSI groups are}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid7497512\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15623646\charrsid726654 reasonably}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3948774\charrsid726654 
 balanced (12 and 19 for the low and high RSI respectively) and the differences of mucin gene expression patterns between the 2 groups are clear. In the RFS groups, the}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13850843\charrsid726654 re was a}{\rtlch\fcs1 
\af0 \ltrch\fcs0 \insrsid3948774\charrsid726654  small number of patients in low RFS group }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13850843\charrsid726654 (2 patients) }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3948774\charrsid726654 
compared to the high RFS group which included the majority of patients}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13850843\charrsid726654  (29 patients)}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3948774\charrsid726654 . }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid14233946\charrsid726654 Th}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid656491\charrsid726654 e reason of this }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid2512563\charrsid726654 could be }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14233946\charrsid726654 that }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid2512563\charrsid726654 laryngeal surgery was needed only for }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14233946\charrsid726654 patients with }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13850843\charrsid726654 
severe reflux changes (}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14233946\charrsid726654 high RFS}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13850843\charrsid726654 )}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14233946\charrsid726654 . }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid13850843\charrsid726654 Therefore, i}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3948774\charrsid726654 t }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13850843\charrsid726654 was }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3948774\charrsid726654 
unfeasible to a draw a solid conclusion as to the effect of severity of laryngeal mucosal changes on laryngeal mucin gene expression. }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13850843\charrsid726654 This}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid1779952\charrsid726654  also}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid2107867\charrsid726654  reflects the weak correlation between the RSI and RFS. }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5446019\charrsid726654 
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11934246\charrsid726654 The expression patterns in the c}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5446019\charrsid726654 ombin}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11934246\charrsid726654 ed }{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid5446019\charrsid726654 low }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11934246\charrsid726654 and high score}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11237108\charrsid726654  groups }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid11934246\charrsid726654 were }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid4678802\charrsid726654 similar to those of the }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid551676\charrsid726654 high and low}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid4678802\charrsid726654  RSI}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid551676\charrsid726654  groups}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid4678802\charrsid726654 . This }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid2048992\charrsid726654 is because of }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid4678802\charrsid726654 the small number }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15471774\charrsid726654 in}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid4678802\charrsid726654  the low RFS group which also showed }{\rtlch\fcs1 
\af0 \ltrch\fcs0 \insrsid2048992\charrsid726654 a similar mucin gene expression pattern to that of the low RSI group. Although the high RFS group included the majority of patients}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1401100\charrsid726654 
 with many having low RSI}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid2048992\charrsid726654 , }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid8064199\charrsid726654 t}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid2048992\charrsid726654 he combined high score group showed }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid8064199\charrsid726654 no significant difference of mucin gene expression patterns}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12061095\charrsid726654  compared to those of high RSI group}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid8064199\charrsid726654 .}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6959980\charrsid726654  This seems to be due to the strong and distinctive expression patterns of the hig
h RSI group that was slightly diluted but not significantly altered by the addition of the high RFS group.}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5446019\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15797823\charrsid726654 
Given the results of the current study, i}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3948774\charrsid726654 t }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15797823\charrsid726654 seems }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid605680\charrsid726654 that reflux symptoms
}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid551676\charrsid726654  would}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid605680\charrsid726654  reflect the reflux disease more reliably than the laryngeal signs }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid9848370\charrsid726654 and it might be more }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3948774\charrsid726654 appropriate to rely on the RSI as a }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid605680\charrsid726654 predictor }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid3948774\charrsid726654 of the changes of laryngeal mucin gene expression patterns than RFS. 
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid5255206 {\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid14628324\charrsid726654 T}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang1033\langfe2057\langnp1033\insrsid5915655\charrsid726654 he }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid14628324\charrsid726654 different mucin gene expression }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang1033\langfe2057\langnp1033\insrsid5915655\charrsid726654 pattern}{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid14628324\charrsid726654 s in }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang1033\langfe2057\langnp1033\insrsid5915655\charrsid726654 low and high RSI and RFS groups }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid1977966\charrsid726654 compared to }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang1033\langfe2057\langnp1033\insrsid5255206 control}{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid1977966\charrsid726654  mucin expression }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang1033\langfe2057\langnp1033\insrsid5915655\charrsid726654 suggest}{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid1977966\charrsid726654 s }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang1033\langfe2057\langnp1033\insrsid5915655\charrsid726654 that low sc}{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid12729584\charrsid726654 ore groups }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang1033\langfe2057\langnp1033\insrsid2294199\charrsid726654 present a pathological rather than a }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid12729584\charrsid726654 normal}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang1033\langfe2057\langnp1033\insrsid2294199\charrsid726654  group}{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid12729584\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang1033\langfe2057\langnp1033\insrsid5915655\charrsid726654 and }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid15471774\charrsid726654 may be}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang1033\langfe2057\langnp1033\insrsid5915655\charrsid726654  suffering from }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid14618779\charrsid726654 mild }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang1033\langfe2057\langnp1033\insrsid5915655\charrsid726654 reflux }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid14618779\charrsid726654 compared to }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang1033\langfe2057\langnp1033\insrsid5915655\charrsid726654 th}{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid14618779\charrsid726654 ose of }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang1033\langfe2057\langnp1033\insrsid5915655\charrsid726654 high RSI}{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid14618779\charrsid726654  or RFS}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang1033\langfe2057\langnp1033\insrsid5915655\charrsid726654 . Therefore, we }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid9047344\charrsid726654 suggest that}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang1033\langfe2057\langnp1033\insrsid5915655\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid997088\charrsid726654 RSI >}{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid5915655\charrsid726654 
13 }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid997088\charrsid726654 and RFS >}{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid203359\charrsid726654 7}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang1033\langfe2057\langnp1033\insrsid5915655\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid15556257\charrsid726654 re}{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid9047344\charrsid726654 
present }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid5915655\charrsid726654 a di}{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid9047344\charrsid726654 vision }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang1033\langfe2057\langnp1033\insrsid1379141\charrsid726654 line }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid5915655\charrsid726654 between mild and severe LPR groups rather than }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\lang1033\langfe2057\langnp1033\insrsid10696752\charrsid726654 an indication }{\rtlch\fcs1 \af0 \ltrch\fcs0 \lang1033\langfe2057\langnp1033\insrsid5915655\charrsid726654 of the occurrence of LPR. 
\par }\pard \ltrpar\ql \li0\ri0\sb120\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid12061095 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12086812\charrsid726654 
The main limitation of this study was the small number of }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid591600\charrsid726654 control}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12086812\charrsid726654 
 laryngeal mucosal samples. This was due to the clinical and ethical difficulties in obtaining normal l
aryngeal mucosa. Secondly, the number of patients in the low RFS is small as it is unlikely that these patients would require surgical intervention and obtaining laryngeal mucosal biopsies from these patients would face the same ethical and clinical diffi
culties. Further studies with adequate numbers of control and }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid551676\charrsid726654 low RFS}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12086812\charrsid726654  laryngeal mucosal samples }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid551676\charrsid726654 are}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12086812\charrsid726654  required}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12061095\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid551676\charrsid726654 
to elucidate the relationship further between reflux severity and mucin gene expression.  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \cf0\revised\revauth2\revauth1\revdttm118736279\insrsid12061095\charrsid726654 
\par }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid9469842\charrsid726654 Conclusion
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid5127876 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9514993\charrsid726654 E}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5244894\charrsid726654 
xpression }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12277914\charrsid726654 patterns }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5244894\charrsid726654 of mucin genes in reflux }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12086812\charrsid726654 patient\rquote s }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5244894\charrsid726654 laryngeal mucosa}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12277914\charrsid726654  vary with reflux severity}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9514993\charrsid726654 .}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid12277914\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12918613\charrsid726654 The initial }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11799911\charrsid726654 membrane bound mucin genes }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid12918613\charrsid726654 MUC3 and 4 down regulation in mild LPR is reversed by increased reflux severity}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9841201\charrsid726654  whereas }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11799911\charrsid726654 
the secretory mucin gen}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid591600\charrsid726654 e}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11799911\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9841201\charrsid726654 MUC5AC expression is }{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid12061095\charrsid726654 permanently}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9841201\charrsid726654  down regulated. }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13251130\charrsid726654 The }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid9469842\charrsid726654 alter}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13251130\charrsid726654 ed}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9469842\charrsid726654  laryngeal mucin gene expression }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid13251130\charrsid726654 occurs }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9469842\charrsid726654 at the molecular level in laryngeal mucosa}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13251130\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid2836138\charrsid726654 rather than }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9469842\charrsid726654 by }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1917401\charrsid726654 switching }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9469842\charrsid726654 
laryngeal mucosa from respiratory to squamous types. }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9841201\charrsid726654 MUC5AC down regulation in LPR might be involved in the development of laryngeal mucosal changes and }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid12545626\charrsid726654 possibly in the persistence of patients\rquote  symptoms.}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15737377\charrsid726654 
\par }\pard \ltrpar\ql \li0\ri0\sb120\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid1978338 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid16604361\charrsid726654 Acknowledgement}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid16604361\charrsid726654 . The authors would like to thank Prof. J A Koufman}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9969326\charrsid726654 , MD, FACS}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16604361\charrsid726654 , formerly of 
{\*\xmlopen\xmlns2{\factoidname City}}{\*\xmlopen\xmlns2{\factoidname City}}Wake{\*\xmlclose} {\*\xmlopen\xmlns2{\factoidname City}}Forest{\*\xmlclose}{\*\xmlclose}, for }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid551676\charrsid726654 providing}{\rtlch\fcs1 
\af0 \ltrch\fcs0 \insrsid16604361\charrsid726654  the reflux}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12086812\charrsid726654  patients}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1978338\charrsid726654 \rquote }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid16604361\charrsid726654  laryngeal mucosa}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7425780\charrsid726654 l samples}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16604361\charrsid726654 . }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12086812\charrsid726654 
Thanks also are to Dr}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid12086812\charrsid726654  David Hopwood and Dr Neil Kernhan of the Department of Molecular Pathology, {\*\xmlopen\xmlns2{\factoidname City}}Ninewells{\*\xmlclose} 
{\*\xmlopen\xmlns2{\factoidname City}}Hospital{\*\xmlclose} and {\*\xmlopen\xmlns2{\factoidname City}}Medical{\*\xmlclose} {\*\xmlopen\xmlns2{\factoidname City}}School{\*\xmlclose}, {\*\xmlopen\xmlns2{\factoidname City}}Dundee{\*\xmlclose}
 for doing the histological analysis.}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12086812\charrsid726654 
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid12462242 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid3637177\charrsid726654 References  }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 
\b\insrsid9444658\charrsid726654 
\par }\pard \ltrpar\qj \li0\ri0\sb120\sl360\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid3637177 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3637177\charrsid726654 1- }{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid3637177\charrsid726654  HYPERLINK "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_AbstractPlus&term=%22Ali+MS%22%5BAuthor%5D" \\o "Click to search for citations by this author." }{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid13569473\charrsid726654 {\*\datafield 
10d0c9ea79f9bace118c8200aa004ba90b0200000003000000e0c9ea79f9bace118c8200aa004ba90b0e01000068007400740070003a002f002f007700770077002e006e006300620069002e006e006c006d002e006e00690068002e0067006f0076002f0065006e007400720065007a002f00710075006500720079002e00
66006300670069003f00640062003d007000750062006d0065006400260063006d0064003d005300650061007200630068002600690074006f006f006c003d007000750062006d00650064005f004100620073007400720061006300740050006c007500730026007400650072006d003d0025003200320041006c0069002b
004d00530025003200320025003500420041007500740068006f0072002500350044000000795881f43b1d7f48af2c825dc485276300000000a5ab0000000000000000000000000000000000}}}{\fldrslt {\rtlch\fcs1 \af0 \ltrch\fcs0 \cs20\insrsid3637177\charrsid726654 Ali MS}}}\sectd \ltrsect
\pgnrestart\linex0\headery709\footery709\colsx708\endnhere\sectlinegrid360\sectdefaultcl\sectrsid3811107\sftnbj {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3637177\charrsid726654 , }{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid3637177\charrsid726654  HYPERLINK "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_AbstractPlus&term=%22Pearson+JP%22%5BAuthor%5D" \\o "Click to search for citations by this author." }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid13569473\charrsid726654 {\*\datafield 
10d0c9ea79f9bace118c8200aa004ba90b0200000003000000e0c9ea79f9bace118c8200aa004ba90b1601000068007400740070003a002f002f007700770077002e006e006300620069002e006e006c006d002e006e00690068002e0067006f0076002f0065006e007400720065007a002f00710075006500720079002e00
66006300670069003f00640062003d007000750062006d0065006400260063006d0064003d005300650061007200630068002600690074006f006f006c003d007000750062006d00650064005f004100620073007400720061006300740050006c007500730026007400650072006d003d0025003200320050006500610072
0073006f006e002b004a00500025003200320025003500420041007500740068006f0072002500350044000000795881f43b1d7f48af2c825dc485276300000000a5ab0000000000000000000000000000000000}}}{\fldrslt {\rtlch\fcs1 \af0 \ltrch\fcs0 \cs20\insrsid3637177\charrsid726654 
Pearson JP}}}\sectd \ltrsect\pgnrestart\linex0\headery709\footery709\colsx708\endnhere\sectlinegrid360\sectdefaultcl\sectrsid3811107\sftnbj {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9444658\charrsid726654  (2007)}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid3637177\charrsid726654  Upper airway mucin gene expression: a review. }{\field\fldedit{\*\fldinst {\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \insrsid3637177\charrsid726654  HYPERLINK "javascript:AL_get(this,%20'jour',%20'Laryngoscope.');" }{\rtlch\fcs1 
\ai\af0 \ltrch\fcs0 \insrsid13569473\charrsid726654 {\*\datafield 
00d0c9ea79f9bace118c8200aa004ba90b0200000003000000e0c9ea79f9bace118c8200aa004ba90b7c0000006a006100760061007300630072006900700074003a0041004c005f00670065007400280074006800690073002c00200027006a006f007500720027002c00200027004c006100720079006e0067006f007300
63006f00700065002e00270029003b000000795881f43b1d7f48af2c825dc485276300000000a5ab0000000000000000000000000000000000}}}{\fldrslt {\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \insrsid3637177\charrsid726654 Laryngoscope}}}\sectd \ltrsect
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\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9444658\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3637177\charrsid726654 932-938.
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\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9444658\charrsid726654 , }{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9444658\charrsid726654  HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed?term=Bulmer%20D%5BAuthor%5D&cauthor=t
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\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9444658\charrsid726654 , }{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9444658\charrsid726654 
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\af0 \ltrch\fcs0 \insrsid3637177\charrsid726654 , et al}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9444658\charrsid726654  (2003)}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3637177\charrsid726654  Cell biology of laryngeal epithel
ial defenses in health and disease: further studies. }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \insrsid3637177\charrsid726654 Ann Otol Rhinol Laryngol}{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \insrsid9444658\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid3637177\charrsid726654 112(6):}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9444658\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3637177\charrsid726654 481-491.
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\af0 \ltrch\fcs0 \insrsid3637177\charrsid726654  Laryngopharyngeal reflux: diagnosis and treatment of a controversial disease. }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \cs31\insrsid3637177\charrsid726654 Curr Opin Allergy Clin Immunol}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid3637177\charrsid726654  8(1):}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9444658\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3637177\charrsid726654 28-33.
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\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9444658\charrsid726654 , }{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9444658\charrsid726654 
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\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9444658\charrsid726654 , }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3637177\charrsid726654 et al}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid2300785\charrsid726654  (2008)}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid3637177\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \cs18\insrsid3637177\charrsid726654 Mucin}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3637177\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \cs18\insrsid3637177\charrsid726654 gene expression}{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3637177\charrsid726654  in human }{\rtlch\fcs1 \af0 \ltrch\fcs0 \cs18\insrsid3637177\charrsid726654 laryngeal}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3637177\charrsid726654  epithelia: effect of laryngopharyngeal }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \cs18\insrsid3637177\charrsid726654 reflux}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3637177\charrsid726654 . }{\field\fldedit{\*\fldinst {\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \insrsid3637177\charrsid726654 
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\sectd \ltrsect\pgnrestart\linex0\headery709\footery709\colsx708\endnhere\sectlinegrid360\sectdefaultcl\sectrsid3811107\sftnbj {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3637177\charrsid726654  117(9):}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid2300785\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3637177\charrsid726654 688-695.
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\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3637177\charrsid726654 274\endash 277.
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 Laryngopharyngeal }{\rtlch\fcs1 \af0 \ltrch\fcs0 \cs18\insrsid3637177\charrsid726654 reflux}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3637177\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \cs18\insrsid3637177\charrsid726654 symptoms}{\rtlch\fcs1 \af0 
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\pgnrestart\linex0\headery709\footery709\colsx708\endnhere\sectlinegrid360\sectdefaultcl\sectrsid3811107\sftnbj {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid8136020\charrsid726654  (2003)}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3637177\charrsid726654 
 Abnormal endoscopic pharyngeal and laryngeal findings attributable to }{\rtlch\fcs1 \af0 \ltrch\fcs0 \cs18\insrsid3637177\charrsid726654 reflux}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3637177\charrsid726654 . }{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid3637177\charrsid726654  HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed/12928082" \\o "The American journal of medicine." }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13569473\charrsid726654 {\*\datafield 
10d0c9ea79f9bace118c8200aa004ba90b0200000003000000e0c9ea79f9bace118c8200aa004ba90b7000000068007400740070003a002f002f007700770077002e006e006300620069002e006e006c006d002e006e00690068002e0067006f0076002f007000750062006d00650064002f00310032003900320038003000
380032000000795881f43b1d7f48af2c825dc485276300000000a5ab0000000000000000000000000000000000000000000000000022000000000000000000000000000000}}}{\fldrslt {\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \cs20\insrsid3637177\charrsid726654 Am J Med}}}\sectd \ltrsect
\pgnrestart\linex0\headery709\footery709\colsx708\endnhere\sectlinegrid360\sectdefaultcl\sectrsid3811107\sftnbj {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3637177\charrsid726654  115 Suppl 3A:90S-96S.
\par 14- }{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3637177\charrsid726654  HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed?term=Haggitt%20RC%5BAuthor%5D&cauthor=true&cauthor_uid=10718462" }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid13569473\charrsid726654 {\*\datafield 
00d0c9ea79f9bace118c8200aa004ba90b0200000003000000e0c9ea79f9bace118c8200aa004ba90bde00000068007400740070003a002f002f007700770077002e006e006300620069002e006e006c006d002e006e00690068002e0067006f0076002f007000750062006d00650064003f007400650072006d003d004800
6100670067006900740074002500320030005200430025003500420041007500740068006f0072002500350044002600630061007500740068006f0072003d0074007200750065002600630061007500740068006f0072005f007500690064003d00310030003700310038003400360032000000795881f43b1d7f48af2c82
5dc485276300000000a5ab00000000000000000000000000002b0000000000000000000079000000000000000000680000000000}}}{\fldrslt {\rtlch\fcs1 \af0 \ltrch\fcs0 \cs20\insrsid3637177\charrsid726654 Haggitt RC}}}\sectd \ltrsect
\pgnrestart\linex0\headery709\footery709\colsx708\endnhere\sectlinegrid360\sectdefaultcl\sectrsid3811107\sftnbj {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid8136020\charrsid726654  (2000)}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3637177\charrsid726654 
 Histopathology of reflux-induced esophageal and supraesophageal injuries. }{\field\fldedit{\*\fldinst {\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \insrsid3637177\charrsid726654 
 HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed?term=Haggit%2C%202000%2C%20histopathology%2C%20reflux" \\o "The American journal of medicine." }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \insrsid13569473\charrsid726654 {\*\datafield 
10d0c9ea79f9bace118c8200aa004ba90b0200000003000000e0c9ea79f9bace118c8200aa004ba90bca00000068007400740070003a002f002f007700770077002e006e006300620069002e006e006c006d002e006e00690068002e0067006f0076002f007000750062006d00650064003f007400650072006d003d004800
61006700670069007400250032004300250032003000320030003000300025003200430025003200300068006900730074006f0070006100740068006f006c006f00670079002500320043002500320030007200650066006c00750078000000795881f43b1d7f48af2c825dc485276300000000a5ab000000610000000000
00000000000000000000000000000000720000000000000000002e0000000000}}}{\fldrslt {\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \cs20\insrsid3637177\charrsid726654 Am J Med}}}\sectd \ltrsect
\pgnrestart\linex0\headery709\footery709\colsx708\endnhere\sectlinegrid360\sectdefaultcl\sectrsid3811107\sftnbj {\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \insrsid8136020\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3637177\charrsid726654 
108 Suppl 4a:109S-111S.
\par }\pard \ltrpar\qj \li0\ri2212\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin2212\lin0\itap0\pararsid9727677 {\rtlch\fcs1 \af0 \ltrch\fcs0 \b\insrsid14558732\charrsid726654 
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \b\insrsid3637177\charrsid726654 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid13137573 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid14558732\charrsid726654 Table 1. }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 
\b\insrsid15233958\charrsid726654 P}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid14558732\charrsid726654 atients involved in the study.
\par \ltrrow}\trowd \irow0\irowband0\ltrrow\ts29\trgaph108\trrh587\trleft0\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth9319\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid2260768\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol\tblind108\tblindtype3 \clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth355\clshdrawnil \cellx355\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth4364\clshdrawnil \cellx4719\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth696\clshdrawnil \cellx5415\clvertalc\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth721\clshdrawnil \cellx6136\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1022\clshdrawnil \cellx7158\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1122\clshdrawnil \cellx8280\clvertalc\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1039\clshdrawnil \cellx9319\pard\plain \ltrpar\ql \li0\ri0\sl480\slmult1
\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid13137573\yts29 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \ab\af0\afs22 \ltrch\fcs0 
\b\fs22\insrsid14558732\charrsid726654 \cell Available score data \cell RSI\cell RFS\cell Group 1\cell Group 2\cell Group 3\cell }\pard\plain \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 
\af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14558732\charrsid726654 \trowd \irow0\irowband0\ltrrow\ts29\trgaph108\trrh587\trleft0\trbrdrt\brdrs\brdrw10 \trbrdrl
\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth9319\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid2260768\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol\tblind108\tblindtype3 \clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth355\clshdrawnil \cellx355\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth4364\clshdrawnil \cellx4719\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth696\clshdrawnil \cellx5415\clvertalc\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth721\clshdrawnil \cellx6136\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1022\clshdrawnil \cellx7158\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1122\clshdrawnil \cellx8280\clvertalc\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1039\clshdrawnil \cellx9319\row \ltrrow}\trowd \irow1\irowband1\ltrrow\ts29\trgaph108\trleft0\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb
\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth9319\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid2260768\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol\tblind108\tblindtype3 \clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth355\clshdrawnil \cellx355\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth4364\clshdrawnil \cellx4719\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth696\clshdrawnil \cellx5415\clvertalc\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth721\clshdrawnil \cellx6136\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\clcbpat8\cltxlrtb\clftsWidth3\clwWidth1022\clcbpatraw8 \cellx7158\clvmgf\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \clcbpat17\cltxlrtb\clftsWidth3\clwWidth1122\clcbpatraw17 \cellx8280
\clvmgf\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \clcbpat18\cltxlrtb\clftsWidth3\clwWidth1039\clcbpatraw18 \cellx9319\pard\plain \ltrpar\ql \li0\ri0\sl480\slmult1
\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid13137573\yts29 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 
\fs22\insrsid14558732\charrsid726654 1\cell }{\rtlch\fcs1 \ai\af0\afs22 \ltrch\fcs0 \i\fs22\insrsid14558732\charrsid726654 Both}{\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid14558732\charrsid726654  pre }{\rtlch\fcs1 \ai\af0\afs22 \ltrch\fcs0 
\i\fs22\insrsid14558732\charrsid726654 and}{\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid14558732\charrsid726654  post medical treatment scores available for }{\rtlch\fcs1 \ai\af0\afs22 \ltrch\fcs0 \i\fs22\insrsid14558732\charrsid726654 both}{
\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid14558732\charrsid726654  RSI and RFS  \cell 15\cell 15\cell (*)\cell (**)\cell (***)\cell }\pard\plain \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 
\rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14558732\charrsid726654 \trowd \irow1\irowband1\ltrrow\ts29\trgaph108\trleft0\trbrdrt\brdrs\brdrw10 \trbrdrl
\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth9319\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid2260768\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol\tblind108\tblindtype3 \clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth355\clshdrawnil \cellx355\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth4364\clshdrawnil \cellx4719\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth696\clshdrawnil \cellx5415\clvertalc\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth721\clshdrawnil \cellx6136\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\clcbpat8\cltxlrtb\clftsWidth3\clwWidth1022\clcbpatraw8 \cellx7158\clvmgf\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \clcbpat17\cltxlrtb\clftsWidth3\clwWidth1122\clcbpatraw17 \cellx8280
\clvmgf\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \clcbpat18\cltxlrtb\clftsWidth3\clwWidth1039\clcbpatraw18 \cellx9319\row \ltrrow}\trowd \irow2\irowband2\ltrrow\ts29\trgaph108\trleft0\trbrdrt
\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth9319\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid2260768\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol\tblind108\tblindtype3 \clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth355\clshdrawnil \cellx355\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth4364\clshdrawnil \cellx4719\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth696\clshdrawnil \cellx5415\clvertalc\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth721\clshdrawnil \cellx6136\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1022\clshdrawnil \cellx7158\clvmrg\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \clshdng5000\cltxlrtb\clftsWidth3\clwWidth1122\clcbpatraw17\clshdngraw5000 \cellx8280
\clvmrg\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \clshdng7500\cltxlrtb\clftsWidth3\clwWidth1039\clcbpatraw18\clshdngraw7500 \cellx9319\pard\plain \ltrpar\ql \li0\ri0\sl480\slmult1
\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid13137573\yts29 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 
\fs22\insrsid14558732\charrsid726654 2\cell }{\rtlch\fcs1 \ai\af0\afs22 \ltrch\fcs0 \i\fs22\insrsid14558732\charrsid726654 Only}{\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid14558732\charrsid726654  post medical treatment scores available for }{
\rtlch\fcs1 \ai\af0\afs22 \ltrch\fcs0 \i\fs22\insrsid14558732\charrsid726654 both}{\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid14558732\charrsid726654  RSI and RFS\cell 12\cell 12\cell \cell \cell \cell }\pard\plain \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14558732\charrsid726654 
\trowd \irow2\irowband2\ltrrow\ts29\trgaph108\trleft0\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth9319\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid2260768\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol\tblind108\tblindtype3 \clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth355\clshdrawnil \cellx355\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth4364\clshdrawnil \cellx4719\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth696\clshdrawnil \cellx5415\clvertalc\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth721\clshdrawnil \cellx6136\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1022\clshdrawnil \cellx7158\clvmrg\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \clshdng5000\cltxlrtb\clftsWidth3\clwWidth1122\clcbpatraw17\clshdngraw5000 \cellx8280
\clvmrg\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \clshdng7500\cltxlrtb\clftsWidth3\clwWidth1039\clcbpatraw18\clshdngraw7500 \cellx9319\row \ltrrow}\trowd \irow3\irowband3\ltrrow
\ts29\trgaph108\trleft0\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth9319\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid2260768\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol\tblind108\tblindtype3 \clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth355\clshdrawnil \cellx355\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth4364\clshdrawnil \cellx4719\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth696\clshdrawnil \cellx5415\clvertalc\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth721\clshdrawnil \cellx6136\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1022\clshdrawnil \cellx7158\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1122\clshdrawnil \cellx8280\clvmrg\clvertalc\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \clshdng7500\cltxlrtb\clftsWidth3\clwWidth1039\clcbpatraw18\clshdngraw7500 \cellx9319\pard\plain \ltrpar\ql \li0\ri0\sl480\slmult1
\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid13137573\yts29 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 
\fs22\insrsid14558732\charrsid726654 3\cell }{\rtlch\fcs1 \ai\af0\afs22 \ltrch\fcs0 \i\fs22\insrsid14558732\charrsid726654 Only}{\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid14558732\charrsid726654  post medical treatment RSI }{\rtlch\fcs1 
\ai\af0\afs22 \ltrch\fcs0 \i\fs22\insrsid14558732\charrsid726654 or}{\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid14558732\charrsid726654  RFS\cell 5\cell 1\cell \cell \cell \cell }\pard\plain \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14558732\charrsid726654 
\trowd \irow3\irowband3\ltrrow\ts29\trgaph108\trleft0\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth9319\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid2260768\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol\tblind108\tblindtype3 \clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth355\clshdrawnil \cellx355\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth4364\clshdrawnil \cellx4719\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth696\clshdrawnil \cellx5415\clvertalc\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth721\clshdrawnil \cellx6136\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1022\clshdrawnil \cellx7158\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1122\clshdrawnil \cellx8280\clvmrg\clvertalc\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \clshdng7500\cltxlrtb\clftsWidth3\clwWidth1039\clcbpatraw18\clshdngraw7500 \cellx9319\row \ltrrow}\pard\plain \ltrpar\ql \li0\ri0\sl480\slmult1
\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid13137573\yts29 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 
\fs22\insrsid14558732\charrsid726654 4\cell }{\rtlch\fcs1 \ai\af0\afs22 \ltrch\fcs0 \i\fs22\insrsid14558732\charrsid726654 Only}{\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid14558732\charrsid726654  pre medical treatment RSI }{\rtlch\fcs1 
\ai\af0\afs22 \ltrch\fcs0 \i\fs22\insrsid14558732\charrsid726654 or}{\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid14558732\charrsid726654  RFS\cell 1\cell 3\cell \cell \cell \cell }\pard\plain \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14558732\charrsid726654 
\trowd \irow4\irowband4\lastrow \ltrrow\ts29\trgaph108\trleft0\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth9319\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid2260768\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol\tblind108\tblindtype3 \clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth355\clshdrawnil \cellx355\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth4364\clshdrawnil \cellx4719\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth696\clshdrawnil \cellx5415\clvertalc\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth721\clshdrawnil \cellx6136\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1022\clshdrawnil \cellx7158\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1122\clshdrawnil \cellx8280\clvmrg\clvertalc\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \clshdng7500\cltxlrtb\clftsWidth3\clwWidth1039\clcbpatraw18\clshdngraw7500 \cellx9319\row }\pard \ltrpar\ql \li0\ri0\sl480\slmult1
\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid13137573 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid14558732\charrsid726654 
\par Group 1}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\super\insrsid14558732\charrsid726654 (*)}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14558732\charrsid726654 :}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6502062\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid4816743\charrsid726654 Average reduction of RSI and RFS after medical treatment was studied in this group.}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14558732\charrsid726654 
\par }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid14558732\charrsid726654 Group 2}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\super\insrsid14558732\charrsid726654 (**)}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14558732\charrsid726654 :}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid10428691\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7211561\charrsid726654 Correlation between RSI and RFS was studied in this group with }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5137420\charrsid726654 acid suppression therapy (AST) }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7211561\charrsid726654 post medical treatment RSI and RFS}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid10428691\charrsid726654 .}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7211561\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid14558732\charrsid726654 
\par }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid14558732\charrsid726654 Group 3}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\super\insrsid14558732\charrsid726654 (***)}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14558732\charrsid726654 
: Total number of patients with RSI (33) and RFS (31) }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6761739\charrsid726654 involved in}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid10895026\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14558732\charrsid726654 
mucin gene study. }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7436631\charrsid726654 As the post }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14438695\charrsid726654 AST}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7436631\charrsid726654  changes of RS
I and RFS were small, 1 and 3 patients with }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid7436631\charrsid726654 only}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7436631\charrsid726654  pre treatment RSI and RFS scores respectively were }{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid8740266\charrsid726654 added }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14438695\charrsid726654 in }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7436631\charrsid726654 mucin gene expression }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid14438695\charrsid726654 analysis }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7436631\charrsid726654 (bottom row). }{\rtlch\fcs1 \af0 \ltrch\fcs0 \b\insrsid14558732\charrsid726654 
\par }\pard \ltrpar\qj \li0\ri2212\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin2212\lin0\itap0\pararsid9727677 {\rtlch\fcs1 \af0 \ltrch\fcs0 \b\insrsid14558732\charrsid726654 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \b\insrsid14558732 
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \b\insrsid13764363 
\par 
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \b\insrsid13764363\charrsid726654 
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \b\insrsid14558732\charrsid726654 
\par }\pard \ltrpar\qj \li0\ri70\sl480\slmult1\widctlpar\tx9000\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin70\lin0\itap0\pararsid12805954 {\rtlch\fcs1 \af0 \ltrch\fcs0 \b\insrsid9727677\charrsid726654 Table }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\b\insrsid12473298\charrsid726654 2}{\rtlch\fcs1 \af0 \ltrch\fcs0 \b\insrsid9727677\charrsid726654 . In situ hybridisation results of mucin gene expression in }{\rtlch\fcs1 \af0 \ltrch\fcs0 \b\insrsid12805954 control }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\b\insrsid9727677\charrsid726654 laryngeal mucosa.
\par \ltrrow}\trowd \irow0\irowband-1\ltrrow\ts36\trgaph108\trleft-108\trbrdrt\brdrs\brdrw15\brdrcf1 \trbrdrl\brdrs\brdrw15\brdrcf1 \trbrdrb\brdrs\brdrw15\brdrcf1 \trbrdrr\brdrs\brdrw15\brdrcf1 \trbrdrh\brdrs\brdrw15\brdrcf1 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid6686106\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol\tblind0\tblindtype3 \clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl
\brdrs\brdrw15\brdrcf1 \clbrdrb\brdrs\brdrw30\brdrcf1 \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth2808\clshdrawnil \cellx2700\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw30\brdrcf1 \clbrdrr\brdrtbl 
\cltxlrtb\clftsWidth3\clwWidth1365\clshdrawnil \cellx4065\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw30\brdrcf1 \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx5199\clvertalc\clbrdrt
\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw30\brdrcf1 \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx6333\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw30\brdrcf1 \clbrdrr\brdrtbl 
\cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx7467\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw30\brdrcf1 \clbrdrr\brdrs\brdrw15\brdrcf1 \cltxlrtb\clftsWidth3\clwWidth1256\clshdrawnil \cellx8723\pard\plain \ltrpar
\qc \li0\ri0\sl480\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\tscfirstrow\tscfirstcol\yts36 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {
\rtlch\fcs1 \ab\ai\af0 \ltrch\fcs0 \b\insrsid13437947\charrsid726654 Mucosa\cell }\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\tscfirstrow\yts36 \rtlch\fcs1 
\af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \b\insrsid13437947\charrsid726654 MUC1\cell }\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1
\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\tscfirstrow\yts36 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \ai\af0 \ltrch\fcs0 
\b\insrsid13437947\charrsid726654 MUC2\cell }\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\tscfirstrow\yts36 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \b\insrsid13437947\charrsid726654 MUC3\cell }\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1
\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\tscfirstrow\yts36 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \ab\ai\af0 \ltrch\fcs0 
\b\insrsid13437947\charrsid726654 MUC4\cell }\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\tscfirstrow\yts36 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid13437947\charrsid726654 MUC5AC\cell }\pard\plain \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 
\af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13437947\charrsid726654 \trowd \irow0\irowband-1\ltrrow\ts36\trgaph108\trleft-108\trbrdrt\brdrs\brdrw15\brdrcf1 \trbrdrl
\brdrs\brdrw15\brdrcf1 \trbrdrb\brdrs\brdrw15\brdrcf1 \trbrdrr\brdrs\brdrw15\brdrcf1 \trbrdrh\brdrs\brdrw15\brdrcf1 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid6686106\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol\tblind0\tblindtype3 \clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl
\brdrs\brdrw15\brdrcf1 \clbrdrb\brdrs\brdrw30\brdrcf1 \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth2808\clshdrawnil \cellx2700\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw30\brdrcf1 \clbrdrr\brdrtbl 
\cltxlrtb\clftsWidth3\clwWidth1365\clshdrawnil \cellx4065\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw30\brdrcf1 \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx5199\clvertalc\clbrdrt
\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw30\brdrcf1 \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx6333\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw30\brdrcf1 \clbrdrr\brdrtbl 
\cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx7467\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw30\brdrcf1 \clbrdrr\brdrs\brdrw15\brdrcf1 \cltxlrtb\clftsWidth3\clwWidth1256\clshdrawnil \cellx8723\row \ltrrow
}\trowd \irow1\irowband0\ltrrow\ts36\trgaph108\trleft-108\trbrdrt\brdrs\brdrw15\brdrcf1 \trbrdrl\brdrs\brdrw15\brdrcf1 \trbrdrb\brdrs\brdrw15\brdrcf1 \trbrdrr\brdrs\brdrw15\brdrcf1 \trbrdrh\brdrs\brdrw15\brdrcf1 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid6686106\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol\tblind0\tblindtype3 \clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl
\brdrs\brdrw15\brdrcf1 \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth2808\clshdrawnil \cellx2700\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrtbl 
\cltxlrtb\clftsWidth3\clwWidth1365\clshdrawnil \cellx4065\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx5199\clvertalc\clbrdrt
\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx6333\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrtbl 
\cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx7467\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrs\brdrw15\brdrcf1 \cltxlrtb\clftsWidth3\clwWidth1256\clshdrawnil \cellx8723\pard\plain \ltrpar
\qc \li0\ri0\sl480\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\tscfirstcol\yts36 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 
\ab\af0 \ltrch\fcs0 \b\insrsid13437947\charrsid726654 Vocal cords\cell }\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\yts36 \rtlch\fcs1 \af0\afs24\alang1025 
\ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13437947\charrsid726654 1/10\cell }\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1
\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\yts36 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid13437947\charrsid726654 1/10\cell }\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\yts36 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13437947\charrsid726654 7/9\cell }\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1
\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\yts36 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid13437947\charrsid726654 9/9\cell }\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\yts36 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13437947\charrsid726654 5/8\cell }\pard\plain \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 
\rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13437947\charrsid726654 \trowd \irow1\irowband0\ltrrow\ts36\trgaph108\trleft-108\trbrdrt\brdrs\brdrw15\brdrcf1 
\trbrdrl\brdrs\brdrw15\brdrcf1 \trbrdrb\brdrs\brdrw15\brdrcf1 \trbrdrr\brdrs\brdrw15\brdrcf1 \trbrdrh\brdrs\brdrw15\brdrcf1 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid6686106\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol\tblind0\tblindtype3 \clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl
\brdrs\brdrw15\brdrcf1 \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth2808\clshdrawnil \cellx2700\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrtbl 
\cltxlrtb\clftsWidth3\clwWidth1365\clshdrawnil \cellx4065\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx5199\clvertalc\clbrdrt
\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx6333\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrtbl 
\cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx7467\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrs\brdrw15\brdrcf1 \cltxlrtb\clftsWidth3\clwWidth1256\clshdrawnil \cellx8723\row \ltrrow
}\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\tscfirstcol\yts36 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid13437947\charrsid726654 Posterior commissure\cell }\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1
\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\yts36 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid13505686\charrsid726654 
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13437947\charrsid726654 0/1}{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13505686\charrsid726654 0      }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid468628\charrsid726654 
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13437947\charrsid726654 \cell }\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\yts36 \rtlch\fcs1 
\af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13437947\charrsid726654 0/10\cell }\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1
\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\yts36 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid13437947\charrsid726654 6/9\cell }\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\yts36 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13437947\charrsid726654 6/9\cell }\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1
\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\yts36 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid13437947\charrsid726654 4/8\cell }\pard\plain \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13437947\charrsid726654 \trowd \irow2\irowband1\ltrrow\ts36\trgaph108\trleft-108\trbrdrt\brdrs\brdrw15\brdrcf1 \trbrdrl\brdrs\brdrw15\brdrcf1 \trbrdrb\brdrs\brdrw15\brdrcf1 \trbrdrr\brdrs\brdrw15\brdrcf1 \trbrdrh
\brdrs\brdrw15\brdrcf1 \trftsWidth1\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid6686106\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol\tblind0\tblindtype3 \clvertalc\clbrdrt
\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrs\brdrw15\brdrcf1 \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth2808\clshdrawnil \cellx2700\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw15\brdrcf1 
\clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1365\clshdrawnil \cellx4065\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx5199\clvertalc\clbrdrt
\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx6333\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrtbl 
\cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx7467\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrs\brdrw15\brdrcf1 \cltxlrtb\clftsWidth3\clwWidth1256\clshdrawnil \cellx8723\row \ltrrow
}\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\tscfirstcol\yts36 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid13437947\charrsid726654 Ventricles\cell }\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1
\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\yts36 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid13437947\charrsid726654 1/10\cell }\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\yts36 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13437947\charrsid726654 1/10\cell }\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1
\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\yts36 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid13437947\charrsid726654 4/9\cell }\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\yts36 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13437947\charrsid726654 7/9\cell }\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1
\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\yts36 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid13437947\charrsid726654 6/8\cell }\pard\plain \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13437947\charrsid726654 \trowd \irow3\irowband2\ltrrow\ts36\trgaph108\trleft-108\trbrdrt\brdrs\brdrw15\brdrcf1 \trbrdrl\brdrs\brdrw15\brdrcf1 \trbrdrb\brdrs\brdrw15\brdrcf1 \trbrdrr\brdrs\brdrw15\brdrcf1 \trbrdrh
\brdrs\brdrw15\brdrcf1 \trftsWidth1\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid6686106\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol\tblind0\tblindtype3 \clvertalc\clbrdrt
\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrs\brdrw15\brdrcf1 \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth2808\clshdrawnil \cellx2700\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw15\brdrcf1 
\clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1365\clshdrawnil \cellx4065\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx5199\clvertalc\clbrdrt
\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx6333\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrtbl 
\cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx7467\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrs\brdrw15\brdrcf1 \cltxlrtb\clftsWidth3\clwWidth1256\clshdrawnil \cellx8723\row \ltrrow
}\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\tscfirstcol\yts36 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0 \ltrch\fcs0 \b\insrsid13437947\charrsid726654 Total\cell }\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1
\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\yts36 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid13437947\charrsid726654 2/30 }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13505686\charrsid726654 
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13437947\charrsid726654 (6.7%)\cell }\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\yts36 \rtlch\fcs1 
\af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13437947\charrsid726654 2/30 (6.7%)\cell }\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1
\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\yts36 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid13437947\charrsid726654 17/27 (63%)\cell }\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\yts36 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid13437947\charrsid726654 22/27 (81.5%)\cell }\pard\plain \ltrpar\qc \li0\ri0\sl480\slmult1
\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid14896121\yts36 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 
\fs20\insrsid13437947\charrsid726654 15/24 (62.5%)\cell }\pard\plain \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 
\fs24\lang2057\langfe2057\cgrid\langnp2057\langfenp2057 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13437947\charrsid726654 \trowd \irow4\irowband3\lastrow \ltrrow\ts36\trgaph108\trleft-108\trbrdrt\brdrs\brdrw15\brdrcf1 \trbrdrl\brdrs\brdrw15\brdrcf1 \trbrdrb
\brdrs\brdrw15\brdrcf1 \trbrdrr\brdrs\brdrw15\brdrcf1 \trbrdrh\brdrs\brdrw15\brdrcf1 
\trftsWidth1\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid6686106\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol\tblind0\tblindtype3 \clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl
\brdrs\brdrw15\brdrcf1 \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth2808\clshdrawnil \cellx2700\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrtbl 
\cltxlrtb\clftsWidth3\clwWidth1365\clshdrawnil \cellx4065\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx5199\clvertalc\clbrdrt
\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx6333\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrtbl 
\cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx7467\clvertalc\clbrdrt\brdrs\brdrw15\brdrcf1 \clbrdrl\brdrtbl \clbrdrb\brdrs\brdrw15\brdrcf1 \clbrdrr\brdrs\brdrw15\brdrcf1 \cltxlrtb\clftsWidth3\clwWidth1256\clshdrawnil \cellx8723\row }\pard \ltrpar
\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid14896121 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7822204\charrsid726654 
\par Results are expressed as proportion of positive samples to the total number of samples for each area of tested laryngeal mucosa}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3229417\charrsid726654 .}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7822204\charrsid726654   }
{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid7822204\charrsid726654 Normal posterior commissure and vocal cord mucosa was covered by mixed (respiratory and squamous) epithelium whereas normal ve
ntricular mucosa was covered by respiratory epithelium only (results not shown). }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid13316264\charrsid726654 Total s}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid4405104\charrsid726654 ample numbers }{\rtlch\fcs1 \ab\af0 
\ltrch\fcs0 \insrsid13316264\charrsid726654 a}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid4405104\charrsid726654 re not identical as s}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid4405104\charrsid726654 ome laryngeal mucosal samples were too small}{\rtlch\fcs1 
\af0 \ltrch\fcs0 \insrsid3149845\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3229417\charrsid726654 for complete analysis}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid4405104\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid1670960\charrsid726654 and }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid4405104\charrsid726654 were}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3229417\charrsid726654  therefore}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3149845\charrsid726654  }{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid4405104\charrsid726654 excluded. 
\par }\pard \ltrpar\qj \li0\ri2212\sl360\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin2212\lin0\itap0\pararsid16653803 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7822204\charrsid726654 
\par }\pard \ltrpar\ql \li0\ri2212\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin2212\lin0\itap0\pararsid4747877 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7822204\charrsid726654 
\par }\pard \ltrpar\ql \li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid7822204 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7822204\charrsid726654 
\par }\pard \ltrpar\ql \li0\ri0\sb120\sl360\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid12999740 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7822204\charrsid726654 
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6443680\charrsid726654 
\par 
\par 
\par 
\par 
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6443680 
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13764363\charrsid726654 
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid6443680 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid12085740\charrsid726654 Figure legends
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid5725174 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid6443680\charrsid726654 
Figure 1. Mucin gene expression in the low and high RSI laryngeal mucosa.
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid2250410 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6443680\charrsid726654 A comparison between mucin gene expression in }{\rtlch\fcs1 
\af0 \ltrch\fcs0 \insrsid2250410 control}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6443680\charrsid726654  and reflux }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid468628\charrsid726654 patient\rquote s }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6443680\charrsid726654 
laryngeal mucosa, taking into account }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid12198835\charrsid726654 patients\rquote  symptoms measured }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid2058216\charrsid726654 by}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid12198835\charrsid726654  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6443680\charrsid726654 the reflux }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16129949\charrsid726654 symptom index}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6443680\charrsid726654  (RS}{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16129949\charrsid726654 I}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6443680\charrsid726654 )}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid2058216\charrsid726654 .}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6443680\charrsid726654  

\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid6443680 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6443680\charrsid726654 
\par 
\par 
\par 
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid2762645 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid6443680\charrsid726654 Figure }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 
\b\insrsid3617454\charrsid726654 2}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid6443680\charrsid726654 . Mucin gene expression in the combined }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid2762645\charrsid726654 low and }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 
\b\insrsid6443680\charrsid726654 high R}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid16389160\charrsid726654 SI}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid6443680\charrsid726654  + RFS laryngeal mucosa.
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid2250410 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6443680\charrsid726654 A comparison between mucin gene expression in }{\rtlch\fcs1 
\af0 \ltrch\fcs0 \insrsid2250410 co}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6443680\charrsid726654 n}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid2250410 t}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6443680\charrsid726654 r}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid2250410 o}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6443680\charrsid726654 l and reflux}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid468628\charrsid726654  patient\rquote s}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6443680\charrsid726654 
 laryngeal mucosa, taking into account the combined low reflux }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid4808045\charrsid726654 symptom }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6443680\charrsid726654 index (RSI) and reflux finding score (RFS)}{\rtlch\fcs1 
\af0 \ltrch\fcs0 \insrsid7370526\charrsid726654  and combined high RSI and RFS}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1254640\charrsid726654 .}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6443680\charrsid726654  
\par }\pard \ltrpar\ql \li0\ri0\sl480\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid6443680 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6443680\charrsid726654 
\par }\pard \ltrpar\ql \li0\ri0\sb120\sl360\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid12999740 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid6443680\charrsid726654 
\par 
\par }}

Youez - 2016 - github.com/yon3zu
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