Figure 1: In a mouse model, it was shown that pancreatic cancer-derived exosomes reach salivary gland cells altering their exosome release. Salivary exosomes can be taken up by NK cells causing lower activation, as indicated by lower CD69 (Early activation antigen CD69) and NKG2D (NK killer group 2D receptor) expression. Although the figure refers to humans, its validity in humans has not yet been demonstrated.