et al. Author

Review Article Open Access

In Patients Undergoing Treatment for Opioid Addiction, is Tramadol more Effective than Buprenorphine in Maintaining Patient Comfort during the First 3 to 5 Days after Last Opioid Exposure? A Systematic Review

Author(s):

Glyn Gardner, et al.

Opioid use disorder has emerged as a global healthcare crisis.  Buprenorphine is has become the standard treatment.  Unfortunately, buprenorphine has a relatively high failure rate, as well as a lengthy course of treatment.  Several other medications have been studied to either augment or replace buprenorphine in the treatment of opioid use disorder.  Due to limited available research on the use of tramadol in managing opiate withdrawal, researchers included randomized double-blind studies, randomized open-label studies, and retrospective cohort studies in this review.  A total of six studies met the criteria set for inclusion in this study. A total of 462 participants were included in the six studies. The participants in the studies met the DSM-5 criteria for o... view more»

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