Research Article, J Nanomater Mol Nanotechnol Vol: 2 Issue: 7
Dietary Intake of (-)-Epigallocatechin-3-gallate against Aging and Cancers: Nanoencapsulation of Multi- Rings Still Requires New Rounds!
| Farid Menaa1*, Abder Menaa2, Jacques Tréton3 and Bouzid Menaa4* | |
| 1Fluorotronics, Inc., Department of Nanomedicine, Stem cells and Oncology, 2453 Cades Way, Bldg C, San Diego, CA 92081, USA | |
| 2Centre Médical des Guittières, Department of Nutrition, Dermato-Esthetics and Anti-Aging Medicine 04 rue des Guittières, Saint-Philbert de Grand Lieu 44310, France | |
| 3Université Paris V-René Descartes, UMRS INSERM U872, Department of Geriatry and Gerontology Centre de Recherches des Cordeliers, 15 rue de l'Ecole de Medicine, Paris 75006, France | |
| 4Fluorotronics, Inc., Department of Nanomaterials and Nanobiotechnology, 2453 Cades Way, Bldg C, San Diego, CA 92081, USA | |
| Corresponding authors : Dr. Farid Menaa Fluorotronics, Inc., Department of Nanomedicine, Stem cells and Oncology, 2453 Cades Way, Bldg C, San Diego, CA 92081, USA Tel: +1 (858) 274.2728 E-mail: dr.fmenaa@gmail.com |
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| Dr. Bouzid Menaa Fluorotronics, Inc., Department of Nanomaterials and Nanobiotechnology, 2453 Cades Way, Bldg C, San Diego, CA 92081, USA Tel: +32 (4) 759-28-957 E-mail: bouzid.menaa@gmail.com |
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| Received: April 19, 2013 Accepted: November 18, 2013 Published: November 23, 2013 | |
| Citation: Menaa F, Menaa A, Tréton J, Menaa B (2013) Dietary Intake of (-)-Epigallocatechin-3-gallate against Aging and Cancers: Nanoencapsulation of Multi-Rings Still Requires New Rounds! J Nanomater Mol Nanotechnol 2:7. doi:10.4172/2324-8777.1000131 |
Abstract
Dietary Intake of (-)-Epigallocatechin-3-gallate against Aging and Cancers: Nanoencapsulation of Multi- Rings Still Requires New Rounds!
Polyphenols, a superfamily of naturally occurring phytochemicals, are gaining popularity because of their potential health benefits. Indeed, as demonstrated in ex-vivo and in non-primates models, they exert variable and pleiotropic biological effects (e.g. anti- or pro-oxidant, anti-inflammatory, anti-tumoral, anti-aging) depending on their structure and physicochemical features. However, these effects are often limited Carnauba wax by their overall unstability and bioavailability. The fact that some polyphenols act either as anti-oxidants (e.g. against aging) or as pro-oxidants (e.g. against tumors/cancers), remain an unsolved paradigm. Interestingly, emergent studies suggest that nano-encapsulated polyphenols might overcome some limitations frequently observed with dietary bulk-polyphenols (e.g. bioavailability, pharmacokinetics, targeting, efficacy, toxicity and safety), subsequently potentiating their biological effects. In this context, the case of (-)-epigallocatechin- 3-gallate (EGCG) is quite intriguing.
