Journal of Regenerative Medicine ISSN: 2325-9620

Maria Jose Barrero

Maria Jose Barrero
Laboratory of Biochemistry and Molecular Biology
Rockefeller University, USA

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Biography

Dr. Barrero obtained her Biology degree at the University of Barcelona in 1996. In subsequent advanced studies she has broadly worked in the areas of gene expression with a special focus on the mechanisms by which nuclear receptors regulate transcription. She conducted her PhD studies at the School of Pharmacy at the University of Barcelona. Her thesis work, under the supervision of Dr. Pedro F. Marrero, dissected regulation of the expression of genes involved in fatty acid metabolism and ketogenesis. She also collaborated with the pharmaceutical company SALVAT S.A. toward the design of novel synthetic ligands for the PPAR family of nuclear receptors for use as potential therapeutic agents in obesity and Type II Diabetes. In 2003 she joined the Rockefeller University’s Laboratory of Biochemistry and Molecular Biology headed by Prof. Robert G. Roeder in New York. She was awarded a Fulbright-Generalitat de Catalunya postdoctoral fellowship to study coactivator-based mechanisms of thyroid hormone receptor mediated transcription. She also was the recipient of a Rockefeller University Woman and Science postdoctoral fellowship that aimed to identify and characterize new coactivators involved in the function of the nuclear receptor HNF4. The latter project, carried out in collaboration with Dr. Sohail Malik, led to the characterization of a novel mechanism for orphan nuclear receptor function that entails posttranslational modifications of the receptor and recruitment of chromatin coactivators including histone modifying enzymes. Dr. Barrero joined the CMRB in 2007 and she currently holds a Ramon y Cajal appointment. Her current research is focused on the role of histone modifying enzymes in stem cell pluripotency and differentiation.

Research Interest

Her current research interests include roles of chromatin and histone modifying enzymes in human embryonic stem cell self-renewal and pluripotency.

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