Research Article, J Trauma Stress Disor Treat Vol: 2 Issue: 3
Effects of Minocycline on Changes in Brain Tryptophan Metabolism and the Behavior of Juvenile Mice Elicited By Inescapable-Predator Stress
| Hideki Miura1*, Yu Ando2, Yukihiro Noda2, Norio Ozaki1 and Kenichi Isobe 3 | |
| 3Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan | |
| 2Division of Clinical Science and Neuropsychopharmacology, Graduate School of Pharmacy, Meijo University, Aichi 468-8503, Japan | |
| 3Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan | |
| Corresponding author : Hideki Miura Department of Psychiatry, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan Tel: 81-52-741-2111; Fax: 81-52-744-2293 E-mail: hmiura@med.nagoya-u.ac.jp |
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| Received: May 18, 2013 Accepted: July 02, 2013 Published: July 08, 2013 | |
| Citation: Miura H, Ando Y, Noda Y, Ozaki N, Isobe K (2013) Effects of Minocycline on Changes in Brain Tryptophan Metabolism and the Behavior of Juvenile Mice Elicited By Inescapable-Predator Stress. J Trauma Stress Disor Treat 2:3. doi:10.4172/2324-8947.1000107 |
Abstract
Effects of Minocycline on Changes in Brain Tryptophan Metabolism and the Behavior of Juvenile Mice Elicited By Inescapable-Predator Stress
Traumatic stress in early life can have long-term effects on neurobiological systems and result in morepronounced responses to stress exposure in adulthood, which may underlie an increased risk of psychiatric disorders such as depression and anxiety disorder (including post-traumatic stress disorder). Acute stress in early life activates the brain kynurenine (KYN) pathway, the main tryptophan (TRP) metabolic pathway, which shares TRP with the serotonin (5-HT) pathway. Although the activated KYN pathway is known to play an important role in the pathophysiology of depression, it may also be related to neurobiological changes elicited by stress.
