Washington University School of Medicine, USA view all
The Journal Andrology & Gynecology: Current Research (AGCR) promotes a significant contribution in advancing knowledge about the new research and their role in minimizing the reproductive disorders both in males and females. AGCR includes all major themes pertaining to the disorders that come under andrology and gynecology.
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Molecular Pathology and Therapy of Endometriosis: Revisited
Endometriosis is among one of the most challenging diseases of the 21st century that affects women in their reproductive age, and its aetiology and pathogenesis remains enigmatic. Unravelling the molecular mechanisms that play a role in the etiopathogenesis of endometriosis has been the subject of intense investigation over the last decade. It is a complex hormone dependent and multifactorial disease involving intricate communications of genetic, immunological, hormonal and environmental factors and the clear understanding of the etiopathogenesis of endometriosis is scarce, as indicated by many studies and recent setbacks in clinical trials.
Endometriosis is among Low serum testosterone also known as hypogonadism or Andropause, affects roughly 39% of men over the age of 45. The prevalence of low testosterone increases with age. Researchers have found that the incidence of low testosterone increases from approximately 20% of men over 60, to 30% of men over 70 and 50% of men over 80 years of age.
Microfluidic Device Increases Sperm Concentration by Optimization of Chamber Structure
Intracytoplasmic sperm injection (ICSI) is an extremely timeconsuming and tedious procedure in cases of oligozoospermia, because it is difficult to obtain a sufficient number of motile sperms. To circumvent this difficulty, we previously developed a microfluidic device to increase sperm concentration and reduce time required for ICSI. Here, we improved this device by carefully optimizing its dimensions. We achieved a 10–13-fold enrichment ratio in non-motile human sperms (1.0 × 104 cells/ml) when a chamber height of 1.4 mm was used, and we described a mathematical model to explain the relationship between sperm concentration and enrichment ratio. However, this model was unable to explain the decrease in the enrichment ratio when a chamber height of 1 mm was used.
Role of Escherichia coli Pili Adhesion Molecule to Inhibit Escherichia coli Adhesion to Human Spermatozoa In vitro
To investigate capacity of adhesin molecule to inhibit the adhesion of Escherichia coli (E. coli) to human spermatozoa in vitro. E. coli was obtained by culturing the semen of infertile males. Spermatozoa were taken from healthy donors with normal spermatozoa according to WHO criteria (1999). Pili cutting were performed five times gradually using omnimixer. To find the factions of pili and protein with highest hemagglutinin protein titer, we performed hemagglutination test. Protein isolation was performed using SDS PAGE electrophoresis, electroelusion, dialysis and precipitation. Protein concentration estimation was conducted using Biuret assay method. Spermatozoa were prepared with Sil Select Plus.