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Amy L Firth

Amy L Firth

Amy L Firth, PhD
Department of Medicine
University of Southern California, USA



Amy Firth is currently an independent tenure-track Assistant Professor of Medicine at the University of Southern California (USC) with a primary appointment in the Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine and a secondary appointment in the Department of Stem Cell Biology and Regenerative Medicine. She received both her M.Sc. in Pharmacology and Ph.D. in Pulmonary Physiology and Ion Channel Regulation at the University of Bath, UK. For two years, she was a Postdoctoral Fellow at UC San Diego where she studied pathogenic mechanisms contributing to Pulmonary Hypertension. For this work she was runner-up in the American Heart Association’s Cournand and Comroe Young Investigator Award. This was followed by a Postdoctoral Research Associate position in Professor Inder Verma’s laboratory at the Salk Institute in La Jolla, CA. With support from a CIRM Postdoctoral Fellowship, Dr. Firth focused her research on the development and study of induced pluripotent stem cell (iPSC)- based disease models of human lung disease. To this end, she pioneered approaches for the generation of iPSCs and their robust differentiation to mature respiratory epithelium. Her study showing the development of multiciliated respiratory epithelium from iPSC, published in PNAS (2014), enables the improved and unprecedented study of pulmonary ciliopathies in a human iPSC-based system. In addition, utilizing state of the art gene editing technologies she corrected a disease causing mutation in iPSC she generated from somatic cells of patients with cystic fibrosis and was able to show functional recovery in differentiated epithelial cells; this work was published in Cell Reports (2015). During her time at Salk, Amy was awarded the Caroline tum Suden/Francis A. Hellebrandt Professional Opportunity Award from the American Physiology Society. She currently has 33 peer-reviewed original research papers, 25 reviews/editorials/book chapters and was chief editor of a book entitled “Lung Stem Cells” which will be published by Springer in July 2015.

In 2016, Amy accepted her position at USC. She is now establishing her laboratory to focus on utilizing patient-derived iPSC and state-of-the-art gene editing technologies, such as CRISPR, to a) model and study mechanisms of lung disease development and b) investigate approaches for tissue regeneration and stem cell-mediated repair of the airway epithelium.


Research Interest

Her research interest is to create a reproducible and effective way to study human lung development and disease in a dish.


Finding a Fitting Ending for Asthma
Editorial:  J Pulm Med 2017, 1:1
doi: 10.4172/pmj.1000e101

Richard Barbers

Abstract  |   Full-text  |   PDF  |  
Impact of Chronic Rhinosinusitis on Lung Function: A Critical Appraisal
Research Article:  J Pulm Med 2017, 1:1
doi: 10.4172/pmj.1000101
Sanjeev Mohanty and Bharat I
Abstract  |   Full-text  |   PDF  |  
Asthma Triggers and Control among Adults in an Egyptian Setting
Research Article:  J Pulm Med 2017, 1:1
doi: 10.4172/pmj.1000102
Ekram W Abd El-Wahab, Hassan M Farag, Nessrin A El-Nimr and Hoda A Saad El-Dein
Abstract  |   Full-text  |   PDF  |  
BRAF Mutations in Pulmonary Langerhans Cell Histiocytosis: A Multicentre Survey
Research Article:  J Pulm Med 2017, 1:1
doi: 10.4172/pmj.1000103

Michael A den Bakker, Gerard HGK Gathier, Erik Thunnissen, Willem Vreuls, Nils’t Hart, Rosita L ten Berge, Kees Seldenrijk, Robert Jan van Suylen, Anna MJ van Nistelrooij, Francien H van Nederveen, Matyas Bendek , Wim Timens, Nelly Breeuwsma, Mariël Brinkhuis, Hannie Sietsma, Jeroen Stavast, Jan von der Th

Abstract  |   Full-text  |   PDF  |  
Sporadic Lymphangioleiomyomatosis Presented with Bilateral Pneumothorax
Case Report:  J Pulm Med 2017, 1:1
doi: 10.4172/pmj.1000104

Mohamed Faisal AH, Sharmila N and Yuhanisa A

Abstract  |   Full-text  |   PDF  |  
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