Review Article, Int J Cardiovasc Res Vol: 1 Issue: 3
Molecular Strategies Contributing to Efficient Homing of Bone Marrow Stem Cells
| Fatemeh Pourrajab1,2*, Seyed Khalil Forouzannia1, Seyed Hossain Hekmatimoghadam1,3 and Marjan Tajik kord2 | |
| 1Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | |
| 2Department of Clinical Biochemistry and Molecular Biology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | |
| 3School of paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | |
| Corresponding author : Fatemeh Pourrajab, Ph.D Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Gomhoori BLV, Yazd, Iran, Postal Code: 8917945556 Tel: +983515231421; Fax: +983515253335 E-mail: mina_poorrajab@yahoo.com |
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| Received: July 01, 2012 Accepted: July 28, 2012 Published: August 06, 2012 | |
| Citation: Pourrajab F, Forouzannia SK, Hekmatimoghadam SH, Kord MT (2012) Molecular Strategies Contributing to Efficient Homing of Bone Marrow Stem Cells. Int J Cardiovasc Res 1:3. doi:10.4172/2324-8602.1000102 |
Abstract
Molecular Strategies Contributing to Efficient Homing of Bone Marrow Stem Cells
For successful systemic stem cell therapy, BMSCs must transmigrate across the endothelium and invade their target tissue.A prerequisite for a successful usage of BMSCs is that they exit the blood circulation via transmigration and invasion. The endothelial phenotype selectively modulates BMSCs transmigration and morphological changes. BMSCs exit the blood circulation by integrating into the endothelium, penetrating the basement membrane and invading the surrounding tissue via the formation of plasmic podia.
