Editorial, J Immunodefic Disor Vol: 1 Issue: 1
NLRC5/CITA: A Novel Regulator of Class I Major Histocompatibility Complex Genes
| Koichi S. Kobayashi* |
| Harvard Medical School, USA |
| Corresponding author : Koichi S. Kobayashi Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, USA E-mail: Koichi_Kobayashi@dfci.harvard.edu |
| Received: June 13, 2012 Accepted: June 13, 2012 Published: June 15, 2012 doi:10.4172/2324-853X.1000e102 |
| Citation: Koichi S. Kobayashi (2012) NLRC5/CITA: A Novel Regulator of Class I Major Histocompatibility Complex Genes. J Immunodefic Disor 1:1. doi:10.4172/2324-853X.1000e102 |
Abstract
NLRC5/CITA: A Novel Regulator of Class I Major Histocompatibility Complex Genes
In 1936, Peter Gorer reported one of the most significant work in the history of immunology; the first identification of alloantigen using serum from immunized rabbits and his own blood. This led to the discovery of the Major Histocompatibility Complex (MHC) by his coworker, George Snell at the Jackson Laboratories. After three quarters of a century, this year, 5 laboratories independently reported that mice deficient for NLRC5 display impaired expression of MHC class I molecules, confirming that NLRC5 is a MHC class I transactivator. What does this mean to us?