The University of Texas MD Anderson Cancer Center, USA View all
The Journal of Regenerative Medicine (JRGM) promotes rigorous research that makes a significant contribution in advancing knowledge for developing new therapeutic approaches to prevent and treat life-threatening diseases. JRGM includes all major themes pertaining to regenerative medicine therapies, applications in stem cell and tissue engineering.
Regenerative Medicine is a subscription based journal that provides a range of options to purchase our articles and also permits unlimited Internet Access to complete Journal content. It accepts research, review papers, online letters to the editors & brief comments on previously published articles or other relevant findings in SciTechnol. Articles submitted by authors are evaluated by a group of peer review experts in the field and ensures that the published articles are of high quality, reflect solid scholarship in their fields, and that the information they contain is accurate and reliable.
Chromatin Topology and Long- Range Genomic Interactions
The ability to reprogram somatic cells to pluripotency provides both potential opportunities for regenerative medicine, as well as an intriguing model for studying cell reprogramming. Although the generation of viable cloned mammals from adult cells is technically feasible, knowledge of such processes as chromatin reorganization, genome activation, and epigenetic modifications is necessary to gain a more thorough understanding of gene regulatory networks that govern nuclear programming. Chromatin architecture and genome wide interactions are not only altered during the transition from a somatic to a pluripotent state, but also play active, regulatory roles during differentiation and cell fate commitment.
2-D Graphene and Derivatives- Based Scaffolds in Regenerative Medicine: Innovative Boosters Mimicking 3-D Cell Microenvironment
Regenerative medicine represents a multi-disciplinary medical area of increasing interest due to the major progress in cell and organ transplantations, as well as advances in biomaterials science and bioengineering. In 1993, Langer and Vacanti proposed the combined use of stem cells (SCs), nanomaterials-based scaffolds, and inductive factors as the basis for regenerative medicine (RM). Since then, researchers have been able to fabricate increasingly complex tissue/organ constructs, some of them are even used in clinics today as standard treatment for a variety of conditions (e.g. bone reconstruction).
Mammalian heart cells undergo a marked reduction in proliferative activity shortly after birth, and thereafter grow predominantly by hypertrophy. Our understanding of the molecular mechanisms underlying cardiac maturation and senescence is based largely on studies at the whole-heart level. Here, we investigate the molecular basis of the acquired quiescence of purified neonatal and adult cardiomyocytes, and use microRNA interference as a novel strategy to promote cardiomyocyte cell cycle re-entry. Expression of cyclins and cyclin-dependent kinases (CDKs) and positive modulators were down-regulated, while CDK inhibitors and negative cell cycle modulators were up-regulated during postnatal maturation of cardiomyocytes. The expression pattern of microRNAs also changed dramatically, including increases in miR- 29a, miR-30a and miR-141. Treatment of neonatal cardiomyocytes with miRNA inhibitors anti-miR-29a, anti-miR-30a, and antimiR- 141 resulted in more cycling cells and enhanced expression of Cyclin A2 (CCNA2). Thus, targeted microRNA interference can reactivate postnatal cardiomyocyte proliferation.
Regenerative Potential of Stem Cells for Duchenne Muscular Dystrophy
Duchenne muscular dystrophy (DMD) is a childhood, severe, X-chromosome linked neuromuscular disorder, affecting 1:3500 male births. It is characterized by mutations in the dystrophin gene, leading to the alteration of the open reading frame and consequently to the loss of dystrophin protein synthesis. The muscular degeneration of muscle fibres causes progressive damage leading to death. Currently, there is no curative treatment for DMD , as this disorder can be considered an untreatable fatal disease. Novel therapeutical approaches have been proposed in the last years. Among them, gene replacement theory has gained substantial attention. Targeted exon-skipping through RNA to exclude specific sites of RNA splicing, or with antisense oligonucleotides can induce the restoring of the open reading frame and the production of a functional, even if smaller, dystrophin protein.