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The Journal of Regenerative Medicine (JRGM) promotes rigorous research that makes a significant contribution in advancing knowledge for developing new therapeutic approaches to prevent and treat life-threatening diseases. JRGM includes all major themes pertaining to regenerative medicine therapies, applications in stem cell and tissue engineering.
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Suspended Life - Stem Cells: Are Treatments Possible?
The aim of this meeting, organized by the Italian no-profit associations Stampa Rossoblù, Sicilia Risvegli Onlus, Niemann Pick Onlus, Omphalos, Organizzazione Sindrome di Angelman (Or.S.A.), Cancellautismo, Marco e Andrea Tremante Foundation, was to confer regarding today’s state-of-the-art and novel findings on stem cell research and applications in Italy. The meeting was held in the city of Grottammare – Ascoli Piceno County, under the auspices of Luigi Merlo, the Major of the city, and Piero Celani, the County President.
Stem Cell Therapy for Diabetes: A Call for Efficient Differentiation of Pancreatic Progenitors
Given the capacity of differentiating into functional beta cells in vivo, transplantation of pancreatic progenitors derived from human embryonic stem cells (hESCs) has been considered as a promising avenue in beta cell replacement therapy . Besides the concerns of preventing teratoma formation, reducing host immune system rejection and other related safety issues , generating sufficient number of pancreatic progenitors is one of the priorities before any consideration of clinical application.
Use of Immortalized Differentiated Cells for Regenerative Medicine
Stem cells are touted to offer a potential avenue for curing many conditions such as diabetes, cardiovascular disease and Alzheimer’s disease. The comments raised were of particular significance in regards hurdles for the use of stem cells in regenerative medicine. These include in vivo issues such as cellular survival, senescence, proliferative capacity and differentiation into a functional tissue.
There is growing evidence showing the promise of mesenchymal stromal cells (MSCs) for the treatment of cutaneous wound healing. In a previous study, we have shown that MSCs seeded on an artificial dermal matrix, Integra® enriched with platelet rich plasma (EmatrixTM) have enhanced proliferative potential as compared to those cultured on the scaffold alone. In this study, we wanted to extend the experimentation by evaluating the efficacy of the MSCs bioengineered scaffolds in the healing of skin wounds. To this purpose, full-thickness skin defects were created on the dorsum of rats and covered with (a) Integra®, (b) EmatrixTM , (c) Integra® plus MSCs, (d) and EmatrixTM plus MSCs, or (e) left to heal spontaneously (control). It was found that the presence of MSCs within the scaffolds significantly accelerated wound healing and greatly ameliorated the quality of regenerated skin; it reduced collagen deposition, enhanced re-epithelization, increased neo-angiogenesis and promoted a greater return of hair follicles and sebaceous glands. In conclusion, the results of this study provide strong evidence that the treatment with MSC-seeded scaffolds represents an attractive approach for augmenting the regenerative potential and enhancing cutaneous wound healing.
Stem Cell Extracellular Matrix Interactions in Three- Dimensional System via Integrins
Cells of all types interact with the extracellular matrix (ECM) through integrin-mediated interactions. Adhesion of embryonic stem (ES) cells is necessary for differentiation. We have characterized integrin expression of undifferentiated mES cells and established a system of evaluating the ECM-integrin interactions in three-dimension (3D) using electrospun scaffolds. We observed a higher proliferation rate at early time points in conventional 2D culture with various ECM proteins (collagen IV, laminin, fibronectin, vitronectin) as compared to 3D conditions. At later time points, we observed higher proliferations in 3D culture conditions compared to 2D culture conditions. We also detected the importance of α5, αV, β1, β5 and αVβ5 integrin subunits for cellular adhesion in 3D conditions using a cellular adhesion assay.