Multiple myeloma is also known as myeloma. It is a type of cancer that originates in the plasma cells of the bone marrow. These are protein-making cells which normally make different kinds of proteins that contain the antibodies of the immune system. In multiple myeloma, the plasma cells undergo what is referred to as a malignant transformation and thereby become cancerous. These myeloma cells stop making different protein in response to the immune system needs and instead start to produce a single type of protein called monoclonal or M protein.