Journal Plastic Surgery and Cosmetology

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Biological effects of amniotic membrane on diabetic foot wounds- Systematic review: Emerging and innovative approaches for wound healing and tissue regeneration

Introduction: The amniotic membrane (AM) has biological properties that are beneficial to wound healing process on diabetic foot ulcer (DFU).

Objective: To analyze scientific evidence found in literature about the use of the AM to stimulate DFU wound healing.

Method: It consists of a systematic review about amniotic membrane’s influence assessing the outcomes “wound healing” and “wound healing time”, applied to DFU. We have selected only six randomized controlled trials and the risk of bias was analyzed according to the Cochrane risk of bias tool. Next, we conducted a meta-analysis of the two outcomes to evaluate the evidence level.

Results: 6 clinical trials were selected, with a total of 331 patients. The most common risks of bias in the studies were selection, attrition and detection biases. Concerning the meta-analysis, we found that wound healing in the group treated with amnion occurs 2.5 times more often and is 32 days faster in comparison to the group that used conventional dressings.

Conclusion: There is statistical evidence to support the effectiveness of amnion in comparison to other conventional dressings.

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