Cardiovascular Risk Determined by Genetic Polymorphisms and Epigenetics
Several risk factors for the development of cardiovascular disorders, such dyslipidemias, can trigger phenomena such as atherosclerosis, coronary disease and even infarction. The adoption of healthy lifestyle habits such a low calorie diet with low cholesterol content, rich in unsaturated fatty acids, fibers and antioxidants such as flavonoids and omega-3, abandonment of alcohol and tobacco and physical exercise are some of the most recommended approaches to decrease serum cholesterol and triglyceride concentrations, as well as increase the liver production of High Density Lipoprotein (HDL). However, for some patients, even maintaining a healthy lifestyle, serum lipids levels remain higher than those considered safe, being refractory to conventional treatments with statins, fibrates, sequestering resins, and inhibitors of intestinal cholesterol absorption, for example. In these cases, it has been suggested the involvement of genotypic conditions, both genetic polymorphism or epigenetics, being necessary more specific diagnostic and management designs. Thus, the present editorial for the International Journal of Cardiovascular Research aims to reinforce this area of knowledge, encourage researchers to invest in works focused on this theme and describe a theoretical framework to be considered in clinical practice.