Infectious Diseases: Prevention and Control

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In Silico Analysis of Phytochemicals: A substantial antiviral approach of Herbal medicines on SARS-CoV-2

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2, formerly known as 2019-nCoV, the causative pathogen of Coronavirus Disease 2019 (COVID-19) is a major source of disaster in the 21st century. In the second meeting of the Emergency Committee, the World Health Organization (WHO) declared that COVID-19 is a “public health emergency of international concern” On 30 January 2020.Coronavirus transmitted via airborne droplets from human to human or human to animal. Through membrane ACE-2 exopeptidase receptor coronavirus enters in a human cell. For the treatment of this sudden and lethal disease during COVID-19there are no specific anti-virus drugs or vaccines. Still, the development of these medicines will take months, even years. Currently, there is a need for supportive care and non-specific treatment to improve the symptoms of COVID-19 infected patients.

For this specific indication, the rapid performance of Herbal medicine or Phytochemicals can contribute as an alternative measure. Phytochemicals are a powerful group of chemicals that are derived from plant origin hence causing fewer side effects because of less use of additives, preservatives, or excipients. Hence, this review will focus on some Phytochemicals which may control and prevent SARS-CoV-2. Further, the existing healing options, drugs accessible, ongoing trials, and current diagnostics to treat SARS-CoV-2 have been discussed. We suggested phytochemicals extracted from herbal plants are potential novel therapeutic approaches, completely targeting SARS-CoV-2 and its pathways.

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