New possibilities in the treatment of Chronic Kidney Disease–Mineral and Bone Disorder (CKD-MBD)

Despite the understanding of the problem of treatment CKD-MBD, success in the treatment of this pathology is very modest. This was primarily due to the absent of effective drugs to achieve target biochemical parameters. Recently, new phosphate binders containing iron and calcimimetics have become available for treatment of CKDMBD. The aim of the study was to assess the effect of new drugs on CKD-MBD targets, including FGF-23, Klotho, PTH, P, Ca and others. We got a good effect from the use of a combination of calcimimetics and phosphate binders containing iron. Only an assessment of the changes in all disease markers under the influence of new drugs gave us the opportunity to improve approaches to treating CKDMBD. Conclusions: Based on our own research results, we can conclude that in the treatment of CKD -MBD we must use new highly effective drugs to achieve the target parameters, including FGF 23 and Klotho.