NOA-SERA: Combined Autologous Progenitor Cells and Platelet-Derived Growth Factors for Male Factor Infertility Due to Non-Obstructive Azoospermia (NOA) and Severe Oligoasthenoteratozoospermia (OATS)-A Case Series

Non-Obstructive Azoospermia (NOA) and E-mail: severe Oligoasthenoteratozoospermia (OATS) present significant challenges in male fertility treatment. This case series explores the efficacy of NOA-SERA, a novel therapeutic approach combining autologous progenitor cells and platelet-derived growth factors, in restoring spermatogenesis. Seven patients received intra-testicular injections of NOA-SERA. Follow-up included hormonal profiling, semen analysis, and testicular biopsies. Results indicated progress in 57.14% men and positive pregnancy in 42.85% of patients, with some achieving successful fertilization through ICSI. While promising, the study emphasizes the need for further research with larger cohorts.