Andrology & Gynecology: Current ResearchISSN: 2327-4360

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Peri-ovulatory Phytoestrogen Improves Pregnancy Rate in Women with Polycystic OvarianSyndrome Receiving Ovulation Induction with Clomiphene Citrate

Abstract Background: PCOS is the most common ovarian factor of female infertility, in low resource countries clomiphene citrate is the most popular drug used for induction of ovulation as its price is affordable for most of patients with least side effects. Objective: Evaluate the effect of phytoestrogen in women receiving induction with clomiphene citrate when given peri ovulatory to oppose antiestrogenic effect of clomiphene citrate. Methodology: Prospective study conducted on 500 patients with PCOD who attended infertility clinic, patients were randomized into 2 groups both groups received traditional CC induction , group (1) 225 patients received phyto-estrogen, starting in the 7th day of the cycle till the day of HCG injection ,group(2) 225 patients received clomiphene citrate only. Endometrial thickness and follicular growth were assessed by transvaginal US. When follicles reached 18 mm, 10,000 IU HCG was administered together with timed intercourse. Both groups were compared as regard cumulative pregnancy rate, ovulation, endometrial thickness and change in hormonal milieu. Results: Midluteal serum progesterone was significantly higher in the study group as compared with the control group (15.93 ±1.8 versus 12.93 ± 1.8); endometrial thickness was also greater in the study group as compared with the control group, (10.3 ± 1.1 versus 8.2 ± 0.9). Ovulation in the three cycles was in favor of study group 82.5% versus 80.4% but not statistically significant. The CPR was significantly higher in the study group than in the control group (34.2% vs. 20.8%. P = 0.1). There were 6 cases of multiple pregnancy in the study group and 4 cases in the control group. Conclusion: Adding phytoestrogen to CC induction improve ovulation and pregnancy rate, it is a good option for patients with PCOS seeking for pregnancy treatment with affordable price and minimal side effects

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