Spectrophotometric Determination of Nifedipine and Nicardipine in their Pharmaceutical Preparations
A touchy and particular spectrophotometric strategy was produced for assurance of nifedipine (NIF) and nicardipine (NIC) in their pharmaceutical arrangements. The technique dependent on a fast decrease of the nitro to essential amino gatherings utilizing zinc dust and hydrochloric corrosive. The subsequent essential fragrant amine was exposed to a buildup response with p-dimethyl amino benzaldehyde to create a yellowish-green shade of Schiff’s bases which evaluated spectrophotometrically at the assimilation maxima of 434 and 441 nm for NIF and NIC, separately. Brew’s law was obeyed in the focus ranges 2.0 to 12.0 μg/mL with a constraint of quantitation 1.4 and 1.9 μg/mL and the mean rate recuperations 98.2±0.3 to 99.5±0.3% NIF and NIC, separately. The proposed techniques were effectively applied to examine NIF and NIC in their containers and tablets. Nifedipine (NIF) and nicardipine (NIC) are the prototypical of 1,4-dihydropyridine (1,4-DHP) and calcium channel blockers have the therapeutic activities of peripheral and coronary vasodilation. They are used in the management of hypertension, angina pectoris, and some other cardiovascular disorders. Many analytical methods have been developed for their determination in bulk, pharmaceutical formulations, and in biological fluids such as; Spectrometric methods (Spectrophotometric and spectrofluorimetric, Electrochemical methods, liquid chromatographic method using different modes of detections . Obvious spectrometry is presumably the most broadly utilized explanatory method, it is generally utilized in clinical science, and ecological research centers in light of the fact that numerous substances can be changed over to hued subsidiaries, and the instrumentation is prepared accessible and for the most part genuinely simple to work . The point of the examination was to build up a straightforward strategy for exact routine assurance of these significant medications in our clinical network in Egypt. Absorbance estimations were made on a Shimadzu model 1601 twofold shaft UV/Visible spectrophotometer (Shimadzu, Tokyo, Japan) with two coordinated 1.0 cm thickness quartz cells for test estimations. Jenway 6305, UV-Visible Spectrophotometer (Jenway LTD, U.K), and MLW type thermostatically controlled water shower (Memmert GmbH, Schwabach, Germany).