Utilization of Bupropion-Dextromethorphan to treat Atypical Depression in patients with Borderline Personality Disorder

Borderline personality disorder is a serious mental health condition, commonly associated with other mental conditions like depression, bipolar disorders and PTSD. Borderline personality disorder shares symptoms with other mental illnesses. We had a 23-year old female patient came to a psychiatric facility with symptoms of mood instability, feeling hopelessness and emptiness, hypersensitivity to rejection and sleep irregularities. The patient has a past psychiatric history of borderline personality disorder, general anxiety disorder and attention-deficit hyperactivity disorder. The patient was prescribed numerous SSRIs, SNRIs and stimulants but no improvement in symptoms or side effects were noted. Then, the patient was given combination therapy of dextromethorphan-bupropion for a period of 12 weeks, which significantly improved her symptoms of mood instability and executive functioning. There was a positive response to the combination therapy of dextromethorphan-bupropion. Yet, further studies on dextromethorphan-bupropione combination therapy are required to assess the safety and efficacy of combination therapy of dextromethorphan-bupropione in the long term.