International Journal of Cardiovascular ResearchISSN: 2324-8602

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Research Article, Int J Cardiovasc Res Vol: 3 Issue: 3

Administration of a Synthetic Peptide Derived from the E-domain Region of Mechano-Growth Factor Delays Decompensation Following Myocardial Infarction

Shioura KM1, Pena JR2, and Goldspink PH2*
1Department of Medicine/Section of Cardiology, University of Illinois, Chicago, Illinois, USA
2Department of Physiology & Cardiovascular Center, Medical College of Wisconsin, Milwaukee, USA
Corresponding author : Goldspink PH
Department of Physiology & Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee 26509, USA
Tel: +414-456-7575; Fax: 414-456-6515
E-mail: [email protected]
Received: July 16, 2012 Accepted: August 02, 2012 Published: August 05, 2012
Citation: Shioura KM, Pena JR, Goldspink PH (2014) Administration of a Synthetic Peptide Derived from the E-domain Region of Mechano-Growth Factor Delays Decompensation Following Myocardial Infarction. Int J Cardiovasc Res 3:3. doi:10.4172/2324-8602.1000169

Abstract

Administration of a Synthetic Peptide Derived from the E-domain Region of Mechano-Growth Factor Delays Decompensation Following Myocardial Infarction

Insulin like growth factor-I (IGF-1) isoforms expressed differ structurally in their E-domain regions and their temporal expression profile in response to injury. We and others have reported that Mechano-growth factor (MGF), which is equivalent to human IGF-1c and rodent IGF-1Eb isoforms, is expressed acutely following myocardial infarction (MI) in the mouse heart.

Keywords: IGF-1 isoforms; E-domain; Myocardial Infarction; Cardiovascular function

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