International Journal of Cardiovascular ResearchISSN: 2324-8602

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Research Article, Int J Cardiovasc Res Vol: 1 Issue: 5

Exercise-Association between Rs6226 and Rs6224 Polymorphisms of the Furin Gene and Cardiovascular Diseases

Ewa Podolecka* and Ewa Zukowska-Szczechowska
Department of Internal Medicine, Diabetology and Nephrology, Medical University of Silesia, Zabrze, Poland
Corresponding author : Dr. Ewa Podolecka, PhD
Department of Internal Medicine, Diabetology and Nephrology, Medical University of Silesia, 3 Maja 13/15, 41-800 Zabrze, Poland
Tel: +48 322712511; Fax: +48 322714617
E-mail: [email protected]
Received: November 15, 2012 Accepted: Novemebr 27, 2012 Published: December 06, 2012
Citation: Podolecka E, Zukowska-Szczechowska E (2012) Association between Rs6226 and Rs6224 Polymorphisms of the Furin Gene and Cardiovascular Diseases. Int J Cardiovasc Res 1:5. doi:10.4172/2324-8602.1000113

Abstract

Exercise-Association between Rs6226 and Rs6224 Polymorphisms of the Furin Gene and Cardiovascular Diseases

Genotyping was conducted on 504 subjects with a mean age of 56.7 ± 9.5 years. Allelic discrimination assay was used to detect rs6226 and rs6224 polymorphisms. Along with echocardiography and BP, vascular compliance of large (C1) and small (C2) arteries was also measured.

Keywords: Furin; Functional polymorphisms;Metalloproteinases;Extracellular matrix; Cardiovascular risk factors

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