International Journal of Mental Health & PsychiatryISSN: 2471-4372

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Ana Hategan Author

ahategan@stjosham.on.ca 905-522-1155

Subjects of specialization
cAMP; Phosphodiestease; Serotonin; Zembrin extract; Sceletium tortuosum; Alzheimer?s disease

Affiliation
Department of Behavioral Neurosciences and Psychiatry, McMaster University, Hamilton, Ontario, Canada

Biography

Dr. Ana Hategan is Associate Clinical Professor of Psychiatry in the Department of Psychiatry & Behavioural Neurosciences at McMaster University. She completed her psychiatry residency at University of Ottawa and obtained her subspecialty certification in geriatric psychiatry. Among other medical education leadership positions, she has been an innovator in her role as the curriculum developer for the geriatric psychiatry subspecialty training program since its inception at McMaster University. She is the recipient of several teaching awards for medical education, including the 2018 Certificate of Merit Award from the Canadian Association of Medical Education.

Publications

Review Article Subscription

Exploring Zembrin Extract Derived from South African Plant, Sceletium tortuosum in Targeting cAMP-driven Phosphodiesterase (PDE) Signaling in Alzheimer’s Disease: Synthesis of Evidence

Author(s):

Simon Chiu, Hana Raheb, Kristen Terpstra, JoshVaughan, Michel Farina-Woodbury, Yves Bureau, Zack Cernovsky, Jirui Hou, John Copen, Mariwan Husni, Vladimir Badmeav, Ana Hategan, Mujeeb Shad, Zach Suntras, Nigel Gericke

Recently with the changing landscape of the aging population and the increase in incidence of Alzheimer’s disease (AD), there has been marked interest to develop strategies to prevent, delay and modify AD. We review the diverse lines of evidence in support of the emerging role of cAMP-mediated Phosphodiesterase (PDE) signalling with respect to aging, inflammation and depression. In view of the link of PDE to Epigenetic complex, targeting PDE through designing modulators and inhibitors of PDE may represent a novel approach in AD therapeutics. We... view more»

DOI: 10.4172/2471-4372.1000104

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